Base de dados : MEDLINE
Pesquisa : D02.355.291 [Categoria DeCS]
Referências encontradas : 4366 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 437 ir para página                         

  1 / 4366 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28815966
[Au] Autor:Mukherjee P; Pettersson M; Dutra JK; Xie L; Am Ende CW
[Ad] Endereço:Pfizer Worldwide Research & Development, Eastern Point Road, Groton, CT, 06340, USA.
[Ti] Título:Trifluoromethyl Oxetanes: Synthesis and Evaluation as a tert-Butyl Isostere.
[So] Source:ChemMedChem;12(19):1574-1577, 2017 Oct 09.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The synthesis of a new trifluoromethyl oxetane was developed using a Corey-Chaykovsky epoxidation/ring-expansion reaction of trifluoromethyl ketones. The reaction was shown to proceed under mild conditions and displays a broad substrate scope. The trifluoromethyl oxetane was also evaluated as a tert-butyl isostere in the context of the γ-secretase modulator (GSM) program. We demonstrate that the trifluoromethyl oxetane-containing GSM has decreased lipophilicity, improved lipophilic efficiency (LipE) and metabolic stability relative to the corresponding tert-butyl GSM analogue, thus highlighting several benefits of trifluoromethyl oxetane as a more polar tert-butyl isostere.
[Mh] Termos MeSH primário: Éteres Cíclicos/química
[Mh] Termos MeSH secundário: Secretases da Proteína Precursora do Amiloide/química
Secretases da Proteína Precursora do Amiloide/metabolismo
Peptídeos beta-Amiloides/antagonistas & inibidores
Peptídeos beta-Amiloides/metabolismo
Cristalografia por Raios X
Éteres Cíclicos/síntese química
Éteres Cíclicos/metabolismo
Seres Humanos
Cetonas/química
Microssomos/metabolismo
Conformação Molecular
Fragmentos de Peptídeos/antagonistas & inibidores
Fragmentos de Peptídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Ethers, Cyclic); 0 (Ketones); 0 (Peptide Fragments); 0 (amyloid beta-protein (1-42)); EC 3.4.- (Amyloid Precursor Protein Secretases); I279Q16FU6 (oxetane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201700333


  2 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28381710
[Au] Autor:Kuroda T; Ogawa W
[Ad] Endereço:Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University.
[Ti] Título:Search for Novel Antibacterial Compounds and Targets.
[So] Source:Yakugaku Zasshi;137(4):383-388, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Drug-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci (VRE) have been spreading; however, the development of new antibacterial drugs has not progressed accordingly. Novel antibacterial drugs or their candidate seeds need to be developed for effective antibiotic therapy. Under these conditions, the search for novel compounds and novel targets is important. In Okayama University, as a part of the Drug Discovery for Intractable Infectious Diseases project, we are proceeding with the development of antibacterial drugs for the treatment of drug-resistant bacterial infections. We found that riccardin C (a natural product of liverwort) and 6,6'-dihydroxythiobinupharidine (from the crude drug Senkotsu) exhibited strong antibacterial activities, particularly against Gram-positive bacteria. We showed that riccardin C induced cell membrane leakage and that 6,6'-dihydroxythiobinupharidine inhibited DNA topoisomerase IV. Moreover, 6,6'-dihydroxythiobinupharidine exerted synergistic effects with already known anti-MRSA drugs as well as with vancomycin for VRE.
[Mh] Termos MeSH primário: Alcaloides
Antibacterianos
Descoberta de Drogas
Farmacorresistência Bacteriana Múltipla
Éteres Cíclicos
[Mh] Termos MeSH secundário: Alcaloides/farmacologia
Antibacterianos/farmacologia
Produtos Biológicos
Membrana Celular/metabolismo
DNA Topoisomerase IV/antagonistas & inibidores
Éteres Cíclicos/farmacologia
Hepatófitas
Japão
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Enterococos Resistentes à Vancomicina/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Bacterial Agents); 0 (Biological Products); 0 (Ethers, Cyclic); 0 (riccardin C); 30343-70-5 (dihydroxythiobinupharidine); EC 5.99.1.- (DNA Topoisomerase IV)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.16-00235-3


  3 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28358695
[Au] Autor:Epperly MW; Rhieu BH; Franicola D; Dixon T; Cao S; Zhang X; Shields D; Wang H; Wipf P; Greenberger JS
[Ad] Endereço:Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, U.S.A.
[Ti] Título:Induction of TGF-ß by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350.
[So] Source:In Vivo;31(2):159-168, 2017 Mar-Apr.
[Is] ISSN:1791-7549
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: Total-body irradiation and/or administration of chemotherapy drugs in bone marrow transplantation induce cytokines that can suppress engraftment. Fanconi Anemia (FA) patients have a hyperactive responsiveness to the inhibitory cytokine, transforming growth factor-beta (TGF-ß). Small molecule radiation mitigator drugs, JP4-039 and MMS350, were evaluated for suppression of irradiation or drug-induced TGF-ß. MATERIALS AND METHODS: In vivo induction of TGF-ß by total-body ionizing irradiation (TBI), L-phenylalanine mustard (L-PAM), busulfan or fludarabine, was quantified. In parallel, mitigator drug amelioration of TGF-ß induction in FA D2 (FANCD2 ) mouse bone marrow, was studied in vitro. Tissue culture medium, cell lysates, and mouse plasma were analyzed for TGF-ß levels. RESULTS: Induction of TGF-ß levels in FANCD2 and FANCD2 mice and in mouse bone marrow were modulated by both JP4-039 and MMS350. CONCLUSION: Bone marrow transplantation in FA recipients may benefit from administration of small molecule agents that suppress TGF-ß induction.
[Mh] Termos MeSH primário: Medula Óssea/efeitos dos fármacos
Éteres Cíclicos/farmacologia
Anemia de Fanconi/tratamento farmacológico
Anemia de Fanconi/radioterapia
Óxidos de Nitrogênio/farmacologia
Sulfóxidos/farmacologia
Fator de Crescimento Transformador beta/metabolismo
[Mh] Termos MeSH secundário: Animais
Western Blotting
Medula Óssea/metabolismo
Bussulfano/farmacologia
Linhagem Celular
Células Cultivadas
Tratamento Farmacológico/métodos
Anemia de Fanconi/metabolismo
Melfalan/farmacologia
Camundongos da Linhagem 129
Camundongos Endogâmicos C57BL
Camundongos Knockout
Agonistas Mieloablativos/farmacologia
Protetores contra Radiação/farmacologia
Técnicas de Cultura de Tecidos
Fator de Crescimento Transformador beta/sangue
Fator de Crescimento Transformador beta/genética
Vidarabina/análogos & derivados
Vidarabina/farmacologia
Irradiação Corporal Total/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethers, Cyclic); 0 (JP4-039); 0 (MMS350); 0 (Myeloablative Agonists); 0 (Nitrogen Oxides); 0 (Radiation-Protective Agents); 0 (Sulfoxides); 0 (Transforming Growth Factor beta); FA2DM6879K (Vidarabine); G1LN9045DK (Busulfan); P2K93U8740 (fludarabine); Q41OR9510P (Melphalan)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


  4 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28027400
[Au] Autor:Lindsly C; Gonzalez-Islas C; Wenner P
[Ad] Endereço:Physiology Department, Emory University, School of Medicine, Atlanta, Georgia, USA.
[Ti] Título:Elevated intracellular Na concentrations in developing spinal neurons.
[So] Source:J Neurochem;140(5):755-765, 2017 Mar.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Over 25 years ago it was first reported that intracellular chloride levels (Cl ) were higher in developing neurons than in maturity. This finding has had significant implications for understanding the excitability of developing networks and recognizing the underlying causes of hyperexcitability associated with disease and neural injury. While there is some evidence that intracellular sodium levels (Na ) change during the development of non-neural cells, it has largely been assumed that Na is the same in developing and mature neurons. Here, using the sodium indicator SBFI, we test this idea and find that Na is significantly higher in embryonic spinal motoneurons and interneurons than in maturity. We find that Na reaches ~ 60 mM in mid-embryonic development and is then reduced to ~ 30 mM in late embryonic development. By retrogradely labeling motoneurons with SBFI we can reliably follow Na levels in vitro for hours. Bursts of spiking activity, and blocking voltage-gated sodium channels did not influence observed motoneuron sodium levels. On the other hand, Na was reduced by blocking the Na -K -2Cl cotransporter NKCC1, and was highly sensitive to changes in external Na and a blocker of the Na /K ATPase. Our findings suggest that the Na gradient is weaker in embryonic neuronal development and strengthens in maturity in a manner similar to that of Cl .
[Mh] Termos MeSH primário: Espaço Intracelular/metabolismo
Neurônios/metabolismo
Sódio/metabolismo
Medula Espinal/crescimento & desenvolvimento
Medula Espinal/metabolismo
[Mh] Termos MeSH secundário: Animais
Benzofuranos
Embrião de Galinha
Galinhas
Cloretos/metabolismo
Desenvolvimento Embrionário
Éteres Cíclicos
Interneurônios/metabolismo
Neurônios Motores/metabolismo
Técnicas de Patch-Clamp
ATPase Trocadora de Sódio-Potássio/metabolismo
Medula Espinal/embriologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzofurans); 0 (Chlorides); 0 (Ethers, Cyclic); 124549-08-2 (sodium-binding benzofuran isophthalate); 9NEZ333N27 (Sodium); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170623
[Lr] Data última revisão:
170623
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.13936


  5 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27863081
[Au] Autor:Alves M; Grignard B; Boyaval A; Méreau R; De Winter J; Gerbaux P; Detrembleur C; Tassaing T; Jérôme C
[Ad] Endereço:Institut des Sciences Moléculaires, UMR 5255, CNRS Université Bordeaux, 351 Cours de la Libération, 33405, Talence Cedex, France.
[Ti] Título:Organocatalytic Coupling of CO with Oxetane.
[So] Source:ChemSusChem;10(6):1128-1138, 2017 Mar 22.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The organocatalytic coupling of CO with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure, and temperature) on the yield, the product formed, and the selectivity of the reaction are discussed. An onium salt combined with a fluorinated alcohol promotes the efficient and selective organocatalytic synthesis of α,ω-hydroxyl oligocarbonates by coupling CO with oxetanes at 130 °C and at a CO pressure as low as 2 MPa. NMR characterizations were correlated with matrix-assisted laser desorption/ionization with time-of-flight mass spectrometer (MALDI-TOF) analyses for elucidating the structure of the oligomers. Online FTIR studies under pressure, NMR titrations, and DFT calculations allowed an in-depth understanding of the reaction mechanism. Finally, CO -based poly(carbonate-co-urethane)s were synthesized by step-growth polymerization of hydroxyl telechelic oligocarbonates with 4,4'-methylene diphenyl diisocyanate (MDI). The organocatalytic system described herein constitutes an innovative sustainable route to the selective preparation of hydroxyl telechelic carbonates of high interest for many applications, notably for the polyurethane business (especially for coatings or foams).
[Mh] Termos MeSH primário: Dióxido de Carbono/química
Éteres Cíclicos/química
[Mh] Termos MeSH secundário: Benzeno/química
Catálise
Ligações de Hidrogênio
Isocianatos/química
Modelos Moleculares
Conformação Molecular
Polimerização
Poliuretanos/química
Pressão
Compostos de Amônio Quaternário/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethers, Cyclic); 0 (Isocyanates); 0 (Polyurethanes); 0 (Quaternary Ammonium Compounds); 142M471B3J (Carbon Dioxide); CBU2X6BBJR (tetrabutylammonium); I279Q16FU6 (oxetane); J64922108F (Benzene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201601185


  6 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27627183
[Au] Autor:Makkar F; Chakraborty K
[Ad] Endereço:a Central Marine Fisheries Research Institute , Cochin , India.
[Ti] Título:Unprecedented antioxidative cyclic ether from the red seaweed Kappaphycus alvarezii with anti-cyclooxygenase and lipoxidase activities.
[So] Source:Nat Prod Res;31(10):1131-1141, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An unprecedented non-isoprenoid oxocine carboxylate cyclic ether characterised as (3S, 4R, 5S, 6Z)-3-((R)-hexan-2'-yl)-3,4,5,8-tetrahydro-4-methyl-2H-oxocin-5-yl acetate was isolated from the ethyl acetate-methanol extract of the red seaweed Kappaphycus alvarezii. The structure, as well as its relative stereochemistry, was proposed on the basis of extensive spectral data. The antioxidative activity of the isolated metabolite was found to have significantly greater as determined by 1, 1-diphenyl-2-picrylhydrazyl and 2,2'-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid radical scavenging activities (IC ~ 0.3 mg/mL) compared to α-tocopherol (IC > 0.6 mg/mL) and was comparable to the synthetic antioxidants butylated hydroxytoluene and butylated hydroxyanisole (IC ~ 0.35-0.34 mg/mL). The compound exhibited greater activity against COX-2 (cyclooxygenase-2) than COX-1 (cyclooxygenase-1) isoform, and therefore, the selectivity index remained significantly lesser (anti-COX-1 : anti-COX-2 0.87) than synthetic anti-inflammatory drugs (0.02-0.44). No significant difference of in vivo 5-lipoxidase activity (IC 0.95 mg/mL) than ibuprofen (IC 0.93 mg/mL) indicated the potential anti-inflammatory properties of the title compound.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Inibidores de Ciclo-Oxigenase/farmacologia
Éteres Cíclicos/química
Éteres Cíclicos/farmacologia
Inibidores de Lipoxigenase/farmacologia
Alga Marinha/química
[Mh] Termos MeSH secundário: Anti-Inflamatórios não Esteroides/farmacologia
Araquidonato 5-Lipoxigenase/metabolismo
Benzotiazóis
Compostos de Bifenilo
Cromatografia em Camada Delgada
Depuradores de Radicais Livres/farmacologia
Espectroscopia de Ressonância Magnética
Picratos
Espectroscopia de Infravermelho com Transformada de Fourier
Ácidos Sulfônicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Cyclooxygenase Inhibitors); 0 (Ethers, Cyclic); 0 (Free Radical Scavengers); 0 (Lipoxygenase Inhibitors); 0 (Picrates); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); EC 1.13.11.34 (Arachidonate 5-Lipoxygenase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1230113


  7 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27792158
[Au] Autor:Yan X; Zhou YX; Tang XX; Liu XX; Yi ZW; Fang MJ; Wu Z; Jiang FQ; Qiu YK
[Ad] Endereço:Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China. yanxia1201@126.com.
[Ti] Título:Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression.
[So] Source:Mar Drugs;14(11), 2016 Oct 26.
[Is] ISSN:1660-3397
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In order to find new natural products with anti-inflammatory activity, chemical investigation of a 3000-meter deep-sea sediment derived bacteria B5 was carried out. A new macrolactin derivative was isolated and identified as 7,13-epoxyl-macrolactin A ( ). Owing to the existence of the epoxy ring, exhibited a significant inhibitory effect on the expression of inducible nitric oxide and cytokines, compared with previously isolated known macrolactins ( - ). Real-time Polymerase Chain Reaction (PCR) analysis showed that the new compound significantly inhibited the mRNA expressions of inducible nitric oxide synthase (iNOS), interleukin-1ß (IL-1ß), and interleukin-6 (IL-6) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Reverse transcription-PCR analysis demonstrated that the new compound reduced the mRNA expression level of IL-1ß in a concentration-dependent manner.
[Mh] Termos MeSH primário: Bacillus subtilis/metabolismo
Produtos Biológicos/farmacologia
Citocinas/antagonistas & inibidores
Éteres Cíclicos/farmacologia
Óxido Nítrico Sintase Tipo II/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/metabolismo
Anti-Inflamatórios/farmacologia
Linhagem Celular
Citocinas/metabolismo
Interleucina-1beta/metabolismo
Interleucina-6/metabolismo
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Camundongos
Óxido Nítrico Sintase Tipo II/metabolismo
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biological Products); 0 (Cytokines); 0 (Ethers, Cyclic); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (RNA, Messenger); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  8 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27697541
[Au] Autor:Api AM; Belsito D; Bhatia S; Bruze M; Calow P; Dagli ML; Dekant W; Fryer AD; Kromidas L; La Cava S; Lalko JF; Lapczynski A; Liebler DC; Politano VT; Ritacco G; Salvito D; Schultz TW; Shen J; Sipes IG; Wall B; Wilcox DK
[Ad] Endereço:Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: AApi@rifm.org.
[Ti] Título:RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3.
[So] Source:Food Chem Toxicol;97S:S192-S200, 2016 Nov.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).
[Mh] Termos MeSH primário: Éteres Cíclicos/toxicidade
Perfumes/toxicidade
Testes de Toxicidade/métodos
[Mh] Termos MeSH secundário: Animais
Segurança de Produtos ao Consumidor
Dano ao DNA/efeitos dos fármacos
Relação Dose-Resposta a Droga
Avaliação Pré-Clínica de Medicamentos
Determinação de Ponto Final
Éteres Cíclicos/química
Nível de Efeito Adverso não Observado
Perfumes/química
Ratos
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Ethers, Cyclic); 0 (Perfume); 9A87HC7ROD (ethylene brassylate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


  9 / 4366 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27406893
[Au] Autor:Tanaka M; Esaki T; Kenmoku H; Koeduka T; Kiyoyama Y; Masujima T; Asakawa Y; Matsui K
[Ad] Endereço:Department of Biological Chemistry, Faculty of Agriculture and Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi 753-8515, Japan. Electronic address: mytnk.a424@gmail.com.
[Ti] Título:Direct evidence of specific localization of sesquiterpenes and marchantin A in oil body cells of Marchantia polymorpha L.
[So] Source:Phytochemistry;130:77-84, 2016 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Liverworts are a rich source of a diverse array of specialized metabolites, such as terpenoids and benzenoids, which are potentially useful for pharmaceutical or agrochemical applications, and also provide clues to elucidate the strategy by which liverworts adapt to the terrestrial environment. Liverworts, belonging to orders Marchantiales and Jungermanniales, possess oil bodies. In Marchantia polymorpha L., oil bodies are confined to scattered idioblastic oil body cells. It has been assumed that the specialized metabolites in M. polymorpha specifically accumulate in the oil bodies in oil body cells; however, no direct evidence was previously available for this specific accumulation. In this study, direct evidence was obtained using micromanipulation techniques coupled with MS analysis that demonstrated the specific accumulation of sesquiterpenoids and marchantin A in the oil body cells of M. polymorpha thalli. It was also observed that the number of oil body cells increased in thalli grown in low-mineral conditions. The amounts of sesquiterpenoids and marchantin A detected in crude extract prepared from the whole thallus were roughly proportional to the number of oil body cells found in a given volume of thallus, suggesting that oil body cell differentiation and sesquiterpenoid and marchantin A biosynthetic pathways are coordinated with each other.
[Mh] Termos MeSH primário: Bibenzilas/isolamento & purificação
Éteres Cíclicos/isolamento & purificação
Marchantia/química
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Bibenzilas/química
Éteres Cíclicos/química
Gotículas Lipídicas
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bibenzyls); 0 (Ethers, Cyclic); 0 (Sesquiterpenes); 88418-46-6 (marchantin A)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160714
[St] Status:MEDLINE


  10 / 4366 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27388554
[Au] Autor:Mosca S; Yu Y; Rebek J
[Ad] Endereço:The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA.
[Ti] Título:Preparative scale and convenient synthesis of a water-soluble, deep cavitand.
[So] Source:Nat Protoc;11(8):1371-87, 2016 Aug.
[Is] ISSN:1750-2799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cavitands are established tools of supramolecular chemistry and molecular recognition, and they are finding increasing application in sensing and sequestration of physiologically relevant molecules in aqueous solution. The synthesis of a water-soluble, deep cavitand is described. The route comprises six (linear) steps from commercially available precursors, and it relies on the fourfold oligomeric cyclization reaction of resorcinol with 2,3-dihydrofuran that leads to the formation of a shallow resorcinarene framework; condensation with aromatic panels, which deepens the hydrophobic binding cavity; construction of rigid urea functionalities on the upper rim; and the introduction of the water-solubilizing methylimidazolium groups on the lower rim. Late intermediates of the synthesis can be used in the preparation of congener cavitands with different properties and applications, and a sample of such a synthetic procedure is included in this protocol. Emphasis is placed on scaled-up reactions and on purification procedures that afford materials in high yield and avoid chromatographic purification. This protocol provides improvements over previously described procedures, and it enables the preparation of sizable amounts of deep cavitands: 7 g of a water-soluble cavitand can be prepared from resorcinol in 13 working days.
[Mh] Termos MeSH primário: Técnicas de Química Sintética/métodos
Éteres Cíclicos/química
Éteres Cíclicos/síntese química
Resorcinóis/química
Resorcinóis/síntese química
Água/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
Solubilidade
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethers, Cyclic); 0 (Resorcinols); 0 (cavitand); 059QF0KO0R (Water)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1038/nprot.2016.078



página 1 de 437 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde