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  1 / 2210 MEDLINE  
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[PMID]:29175398
[Au] Autor:Qiu N; Wang R; Sun Y; Wang X; Jiang D; Meng Y; Zhou F
[Ad] Endereço:School of Life Science, Qufu Normal University, Qufu, Shandong 273165, China.
[Ti] Título:Toxic effects and mechanism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on Lemna minor.
[So] Source:Chemosphere;193:711-719, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To investigate the toxic effect and mechanism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in aquatic plants, in vivo and in vitro exposure to BDE-47 were conducted. After 14-d exposure to 5-20 µg/L BDE-47, the growth of Lemna minor plants was significantly suppressed, and the chlorophyll and soluble protein contents in fronds markedly decreased. Accordingly, the photosynthetic efficiency (Fv/Fm, PI) decreased. When the thylakoid membranes isolated from healthy fronds was exposed to 5-20 mg/L BDE-47 directly in vitro for 1 h, the photosynthetic efficiency also decreased significantly. In both the in vitro (5-20 µg/L) and in vivo (5-20 mg/L) experiments, BDE-47 led to an increased plasma membrane permeability. Hence, we concluded that BDE-47 had a direct toxicity to photosynthetic membranes and plasma membranes. However, direct effects on the activities of peroxidase (POD), malate dehydrogenase (MDH) and nitroreductase (NR) were not observed by adding 5-20 mg/L BDE-47 into crude enzyme extracts. The malondialdehyde (MDA) and superoxide anion radical (O ) contents in the BDE-47 treated fronds were higher than those in the control fronds, suggesting that L. minor can not effectively relieve reactive oxygen species (ROS). The data above indicates that BDE-47 is toxic to L. minor through acting directly on biomembranes, which induces the production of ROS and thus causes remarkable oxidative damage to cells.
[Mh] Termos MeSH primário: Araceae/efeitos dos fármacos
Éteres Difenil Halogenados/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Araceae/enzimologia
Araceae/metabolismo
Clorofila/metabolismo
Éter
Malondialdeído/metabolismo
Oxirredução
Peroxidase/metabolismo
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Halogenated Diphenyl Ethers); 0 (Reactive Oxygen Species); 0 (Water Pollutants, Chemical); 0F5N573A2Y (Ether); 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether); 1406-65-1 (Chlorophyll); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.7 (Peroxidase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  2 / 2210 MEDLINE  
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[PMID]:27774855
[Au] Autor:Yin S; Xia Y; Jia Q; Hou ZS; Zhang N
[Ad] Endereço:a Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, College of Chemistry, Chemical Engineering and Materials Science , Shandong Normal University , Jinan , China.
[Ti] Título:Preparation and properties of biomedical segmented polyurethanes based on poly(ether ester) and uniform-size diurethane diisocyanates.
[So] Source:J Biomater Sci Polym Ed;28(1):119-138, 2017 01.
[Is] ISSN:1568-5624
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study describes the preparation and properties of a novel aliphatic cost-effective segmented polyurethanes (SPUs) based on poly(ether ester) (poly-(ε-caprolactone-co-l-lactide)-poly(ethylene glycol)-poly-(ε-caprolactone-co-l-lactide), PECLA) and uniform-size diurethane diisocyanates (HDI-BDO-HDI). PECLA was synthesized via bulk ring-opening polymerization with poly(ethylene glycol) (PEG) as an initiator and ε-caprolactone, l-lactide as monomers. By chain extension of PECLA diol with HDI-BDO-HDI, three SPUs with different hydrophilic segments content and hard segments content were obtained. The chemical structures of the chain extender, PECLA and SPUs were confirmed by H NMR, C NMR, FT-IR, HR-TOF-MS and GPC. The influences of PEG content and uniform-size hard segments on in vitro degradability and mechanical properties of SPU films were researched. Similar thermostability observed in TGA curves of SPU films indicated that the hard segments and PEG content had little influence on the thermostability. The formation of microsphase-separated morphologies, which were demonstrated by the results of DSC and XRD, and physical-linking (H-bonds) network structures led to better mechanical properties of SPU films (ultimate stress: 23.1-17.9 MPa; elongation at break: 840-1130%). The results of water absorption and water contact angle showed that the bulk and surface hydrophilicity were closely related with the hydrophilic PEG content in SPU backbone. And the water absorption being less than 10 wt% indicated that the SPU films had low swelling property. In vitro hydrolytic degradation studies showed that the time of the SPU films becoming fragments was 34-19 days and the degradation rate increased with the increasing content of hydrophilic segments in SPUs, indicating that the degradation rate of SPU films could be controlled by adjusting PEG content. Cytotoxicity test of film extracts were conducted using L929 cells, and the relative growth rate exceeded 90% after incubation for 24, 48 and 72 h, showing excellent cytocompatibility. The acceptable mechanical properties, controllable biodegradability and excellent cytocompatibility of the polyurethanes can make them good candidates for further biomedical applications.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/química
Éter/química
Poliésteres/química
Polietilenoglicóis/química
Poliuretanos/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Materiais Biocompatíveis/toxicidade
Bovinos
Linhagem Celular
Estabilidade de Medicamentos
Fenômenos Mecânicos
Camundongos
Soroalbumina Bovina/química
Temperatura Ambiente
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Polyesters); 0 (Polyurethanes); 0 (poly(epsilon-caprolactone-co-lactide)-poly(ethylene glycol)); 059QF0KO0R (Water); 0F5N573A2Y (Ether); 27432CM55Q (Serum Albumin, Bovine); 30IQX730WE (Polyethylene Glycols)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161104
[St] Status:MEDLINE


  3 / 2210 MEDLINE  
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[PMID]:29117588
[Au] Autor:Wei J; Xiang L; Yuan Z; Li S; Yang C; Liu H; Jiang Y; Cai Z
[Ad] Endereço:State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong Special Administrative Region.
[Ti] Título:Metabolic profiling on the effect of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in MCF-7 cells.
[So] Source:Chemosphere;192:297-304, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polybrominated diphenyl ethers (PBDEs) are commonly used to prevent the development of fire in various factory products. Due to the adverse effects on human health and the bio-accumulation capacity, PBDEs are considered as one kind of persistent organic pollutants (POPs). BDE-47 is one of the most frequently detected PBDEs congeners in human samples. Although numerous studies have shown the close connection between BDE-47 and human health, few reports were related to breast carcinoma. In the present study, the toxicity mechanism of BDE-47 was investigated by using MCF-7 breast cancer cells. Metabolomics analysis was conducted by using ultra-high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS). Results showed that the toxicity to MCF-7 cells gradually increased when the concentration of BDE-47 exceeded 1 µM in the medium with 1% fetal bovine serum (FBS). It was found that pyrimidine metabolism, purine metabolism and pentose phosphate pathway (PPP) were the most influenced metabolic pathways, and the metabolites in the three metabolic pathways were significantly downregulated. Moreover, the increase of reactive oxygen species (ROS) was detected by using the 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) staining method. The obtained results suggested that the BDE-47 induced oxidative stress by downregulating the NADPH generation in PPP. The pyrimidine metabolism and purine metabolism might be downregulated by the downregulation of mRNA transcripts. Therefore, BDE-47 could induce oxidative stress by inhibiting PPP and disorder the metabolism of the entire cell subsequently. This research provided evidence for investigating mechanism of the adverse effect of BDE-47 on human health.
[Mh] Termos MeSH primário: Éteres Difenil Halogenados/toxicidade
[Mh] Termos MeSH secundário: Neoplasias da Mama/patologia
Éter
Éteres Difenil Halogenados/metabolismo
Seres Humanos
Células MCF-7
Espectrometria de Massas
Redes e Vias Metabólicas/efeitos dos fármacos
Metabolômica/métodos
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Halogenated Diphenyl Ethers); 0 (Reactive Oxygen Species); 0F5N573A2Y (Ether); 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171109
[St] Status:MEDLINE


  4 / 2210 MEDLINE  
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[PMID]:28867714
[Au] Autor:Kojima K; Yang ZK; Wang C; Uchiyama M
[Ad] Endereço:Graduate School of Pharmaceutical Sciences, the University of Tokyo.
[Ti] Título:Ethereal C-O Bond Cleavage Mediated by Ni(0)-Ate Complex: A DFT Study.
[So] Source:Chem Pharm Bull (Tokyo);65(9):862-868, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Density functional theory calculations were performed to explore the mechanism of Ni-catalyzed cross-coupling reactions involving organo-lithium and -zinc reagents through ethereal C-O bond cleavage. Based on this work, together with our previous mechanistic study on etheric Kumada-Tamao reaction, we identify and characterize a novel catalytic cycle for cross-coupling mediated by Ni(0)-ate complex.
[Mh] Termos MeSH primário: Carbono/química
Éter/química
Níquel/química
Oxigênio/química
[Mh] Termos MeSH secundário: Catálise
Modelos Moleculares
Compostos Organometálicos/química
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organometallic Compounds); 0F5N573A2Y (Ether); 7440-44-0 (Carbon); 7OV03QG267 (Nickel); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00487


  5 / 2210 MEDLINE  
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[PMID]:28719801
[Au] Autor:Taha M; Imran S; Ismail NH; Selvaraj M; Rahim F; Chigurupati S; Ullah H; Khan F; Salar U; Javid MT; Vijayabalan S; Zaman K; Khan KM
[Ad] Endereço:Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), University of Dammam, Dammam 31441, Saudi Arabia. Electronic address: taha_hej@yahoo.com.
[Ti] Título:Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies.
[So] Source:Bioorg Chem;74:1-9, 2017 Oct.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new library of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives (1-23) were synthesized and characterized by EI-MS and H NMR, and screened for their α-amylase inhibitory activity. Out of twenty-three derivatives, two molecules 19 (IC =0.38±0.82µM) and 23 (IC =1.66±0.14µM), showed excellent activity whereas the remaining compounds, except 10 and 17, showed good to moderate inhibition in the range of IC =1.77-2.98µM when compared with the standard acarbose (IC =1.66±0.1µM). A plausible structure-activity relationship has also been presented. In addition, in silico studies was carried out in order to rationalize the binding interaction of compounds with the active site of enzyme.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Éter/farmacologia
Imidazóis/farmacologia
Simulação de Acoplamento Molecular
alfa-Amilases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Éter/síntese química
Éter/química
Imidazóis/síntese química
Imidazóis/química
Estrutura Molecular
Relação Estrutura-Atividade
Suínos
alfa-Amilases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Imidazoles); 0F5N573A2Y (Ether); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


  6 / 2210 MEDLINE  
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[PMID]:28717108
[Au] Autor:Nakatsu N; Igarashi Y; Aoshi T; Hamaguchi I; Saito M; Mizukami T; Momose H; Ishii KJ; Yamada H
[Ad] Endereço:Toxicogenomics Informatics Project, National Institute of Biomedical Innovation, Health and Nutrition.
[Ti] Título:Isoflurane is a suitable alternative to ether for anesthetizing rats prior to euthanasia for gene expression analysis.
[So] Source:J Toxicol Sci;42(4):491-497, 2017.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Diethyl ether (ether) had been widely used in Japan for anesthesia, despite its explosive properties and toxicity to both humans and animals. We also had used ether as an anesthetic for euthanizing rats for research in the Toxicogenomics Project (TGP). Because the use of ether for these purposes will likely cease, it is required to select an alternative anesthetic which is validated for consistency with existing TGP data acquired under ether anesthesia. We therefore compared two alternative anesthetic candidates, isoflurane and pentobarbital, with ether in terms of hematological findings, serum biochemical parameters, and gene expressions. As a result, few differences among the three agents were observed. In hematological and serum biochemistry analysis, no significant changes were found. In gene expression analysis, four known genes were extracted as differentially expressed genes in the liver of rats anesthetized with ether, isoflurane, or pentobarbital. However, no significant relationships were detected using gene ontology, pathway, or gene enrichment analyses by DAVID and TargetMine. Surprisingly, although it was expected that the lung would be affected by administration via inhalation, only one differentially expressed gene was extracted in the lung. Taken together, our data indicate that there are no significant differences among ether, isoflurane, and pentobarbital with respect to effects on hematological parameters, serum biochemistry parameters, and gene expression. Based on its smallest affect to existing data and its safety profile for humans and animals, we suggest isoflurane as a suitable alternative anesthetic for use in rat euthanasia in toxicogenomics analysis.
[Mh] Termos MeSH primário: Anestesia
Anestésicos Inalatórios
Éter
Eutanásia Animal
Isoflurano
Ratos Sprague-Dawley/sangue
Ratos Sprague-Dawley/genética
Transcriptoma
[Mh] Termos MeSH secundário: Anestésicos Inalatórios/toxicidade
Animais
Éter/toxicidade
Fígado
Pulmão
Masculino
Pentobarbital
Toxicogenética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0F5N573A2Y (Ether); CYS9AKD70P (Isoflurane); I4744080IR (Pentobarbital)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.2131/jts.42.491


  7 / 2210 MEDLINE  
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[PMID]:28701653
[Au] Autor:Asakawa Y; Ludwiczuk A; Sakurai K; Tomiyama K; Kawakami Y; Yaguchi Y
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:Comparative Study on Volatile Compounds of Alpinia japonica and Elettaria cardamomum.
[So] Source:J Oleo Sci;66(8):871-876, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The volatile compounds obtained from the ether extracts, headspace gases and steam distillates of Alpinia japonica and Elettaria cardamomum were analyzed by GC/MS. Both species were rich sources of naturally rare fenchane-type monoterpenoids, fenchene, fenchone, fenchyl alcohol and its acetate, together with 1,8-cineole. The distributions of volatile sesquiterpenoids were very poor in both species. Chiralities of fenchone in A. japonica and E. cardamomum were 99% of (1S,4R)-(+)-form. Camphor in A. japonica is composed of a mixture of (1R,4R)-(+)-form (94.3%) and (1S,4S)-(-)-form (5.7%). On the other hand, E. cardamomum produced only (1R,4R)-(+)-camphor (99%).
[Mh] Termos MeSH primário: Alpinia/química
Elettaria/química
Monoterpenos/análise
Extratos Vegetais/química
Sesquiterpenos/análise
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Cânfora/análise
Cicloexanóis/análise
Éter
Cromatografia Gasosa-Espectrometria de Massas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexanols); 0 (Monoterpenes); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Volatile Organic Compounds); 0F5N573A2Y (Ether); 76-22-2 (Camphor); RV6J6604TK (eucalyptol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17048


  8 / 2210 MEDLINE  
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[PMID]:28675799
[Au] Autor:Mather LE
[Ad] Endereço:Emeritus Professor of Anaesthesia, The University of Sydney, Sydney, New South Wales.
[Ti] Título:Dr Snow killed a bird: The genesis of pharmacokinetics and pharmacodynamics in anaesthesia.
[So] Source:Anaesth Intensive Care;45(7):37-44, 2017 03.
[Is] ISSN:0310-057X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:This essay presents a pharmacologist's perspective of what would be now called 'preclinical research' and 'uncontrolled clinical trials' surrounding the first public demonstration by William Thomas Green Morton of painless surgery achieved by the inhalation of ether in a patient at the Massachusetts General Hospital on 16 October 1846. Of the many people who made history in those earliest days of surgical anaesthesia in both the United States and Great Britain, John Snow stands out for his personal research that spanned basic science and clinical medicine. Primarily, Snow used the relationship between the vapour pressure of a volatile liquid and temperature to design a vaporiser. This allowed control of the inspired concentration of the volatile liquid epitomised by diethyl ether, and thus the time-course and depth of anaesthesia. In an era when developments in anaesthesia were almost exclusively based on empirical modifications to apparatus and technique, Snow, and to a lesser extent his contemporary Andrew Buchanan, stood out from all others in advancing the quantitative basis of anaesthesia. Both described the physiological basis of control over gas uptake whereby they related that gas moved across concentration gradients in the body: alveolar to arterial to tissue to venous gas tensions, and Snow devised a progressional semi-quantitative scale of five 'stages' of ether anaesthesia. They thereby introduced the elements of what would be referred to 'pharmacokinetics' and 'pharmacodynamics', a century later. This essay attempts to place them and their scientific insights into context with contemporaneous principal personae and knowledge.
[Mh] Termos MeSH primário: Anestésicos Inalatórios/história
Éter/história
[Mh] Termos MeSH secundário: Éter/farmacocinética
Éter/farmacologia
História do Século XVIII
História do Século XIX
Seres Humanos
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE; PORTRAITS
[Ps] Nome de pessoa como assunto:Snow J
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0F5N573A2Y (Ether)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  9 / 2210 MEDLINE  
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[PMID]:28675798
[Au] Autor:Haridas RP; Paull JD
[Ad] Endereço:Honorary Curator, Harry Daly Museum and Honorary Librarian, Richard Bailey Library, Australian Society of Anaesthetists, Sydney, New South Wales.
[Ti] Título:St John's Hospital (Morton House), Launceston, Australia: A history of the hospital and Dr William Russ Pugh's first operations under ether.
[So] Source:Anaesth Intensive Care;45(7):29-36, 2017 03.
[Is] ISSN:0310-057X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:On 7 June 1847, William Russ Pugh, MD, performed two operations at the St John's Hospital and Self-Supporting Dispensary, Launceston, Tasmania, while his patients were rendered insensible by the inhalation of sulphuric ether. These operations are the earliest documented surgical operations under ether in Australia. St John's Hospital officially opened on 1 September 1845. The hospital may have closed in late 1853 because of financial difficulties. The two-storey Georgian-style building which served as the hospital was completed c1831-1832. It has served as a residence, school, boarding school, hospital, medical consulting rooms and commercial offices. The building is now known as Morton House. We could not identify the date when the name Morton House was adopted, or explain the origin of the name. The earliest identified use of this name is in May 1873 in a newspaper advertisement for boarders. No person with the surname Morton is known to have been associated with the building as an owner or as a tenant. The name Morton House may honour William T.G. Morton, MD, the Boston dentist who performed the first public demonstration of surgical etherisation on 16 October 1846.
[Mh] Termos MeSH primário: Anestésicos Inalatórios/história
Éter/história
Hospitais/história
[Mh] Termos MeSH secundário: História do Século XIX
Londres
[Pt] Tipo de publicação:BIOGRAPHY; HISTORICAL ARTICLE; JOURNAL ARTICLE
[Ps] Nome de pessoa como assunto:Pugh WR
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0F5N573A2Y (Ether)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  10 / 2210 MEDLINE  
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[PMID]:28502682
[Au] Autor:Greuter L; Weil AG; Hildebrandt G; Surbeck W
[Ad] Endereço:Department of Neurosurgery, Cantonal Hospital St. Gallen, Switzerland.
[Ti] Título:Intrarectal Anesthesia in Neurosurgery.
[So] Source:World Neurosurg;104:158-160, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the early days of modern neurologic surgery, the inconveniences and potential dangers of general anesthesia by chloroform and ether using the so-called "open-drop technique" led to the quest for alternative methods of anesthesia. This became all the more necessary, since patient positioning and the surgical arrangements often hindered the use of a drop bottle. One approach to solve this problem was intrarectal ether application. The present article aims to shed light on this original, less well-known anesthesia technique in the neurosurgical field.
[Mh] Termos MeSH primário: Administração Retal
Anestesia Local/história
Éter/administração & dosagem
Éter/história
Neurocirurgia/história
[Mh] Termos MeSH secundário: História do Século XIX
História do Século XX
Internacionalidade
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0F5N573A2Y (Ether)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde