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  1 / 2401 MEDLINE  
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[PMID]:29478637
[Au] Autor:Gurtowski LA; Griggs CS; Gude VG; Shukla MK
[Ad] Endereço:Environmental Laboratory, Engineer Research and Development Center, Vicksburg, MS 39180, USA.
[Ti] Título:An integrated theoretical and experimental investigation of insensitive munition compounds adsorption on cellulose, cellulose triacetate, chitin and chitosan surfaces.
[So] Source:J Environ Sci (China);64:174-180, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This manuscript reports results of combined computational chemistry and batch adsorption investigation of insensitive munition compounds, 2,4-dinitroanisole (DNAN), triaminotrinitrobenzene (TATB), 1,1-diamino-2,2-dinitroethene (FOX-7) and nitroguanidine (NQ), and traditional munition compound 2,4,6-trinitrotoluene (TNT) on the surfaces of cellulose, cellulose triacetate, chitin and chitosan biopolymers. Cellulose, cellulose triacetate, chitin and chitosan were modeled as trimeric form of the linear chain of C chair conformation of ß-d-glucopyranos, its triacetate form, ß-N-acetylglucosamine and D-glucosamine, respectively, in the 1➔4 linkage. Geometries were optimized at the M062X functional level of the density functional theory (DFT) using the 6-31G(d,p) basis set in the gas phase and in the bulk water solution using the conductor-like polarizable continuum model (CPCM) approach. The nature of potential energy surfaces of the optimized geometries were ascertained through the harmonic vibrational frequency analysis. The basis set superposition error (BSSE) corrected interaction energies were obtained using the 6-311G(d,p) basis set at the same theoretical level. The computed BSSE in the gas phase was used to correct interaction energy in the bulk water solution. Computed and experimental results regarding the ability of considered surfaces in adsorbing the insensitive munitions compounds are discussed.
[Mh] Termos MeSH primário: Substâncias Explosivas/química
Modelos Químicos
[Mh] Termos MeSH secundário: Adsorção
Anisóis/química
Celulose/análogos & derivados
Celulose/química
Quitina/química
Quitosana/química
Guanidinas/química
Nitrocompostos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,1-diamino-2,2-dinitroethene); 0 (Anisoles); 0 (Explosive Agents); 0 (Guanidines); 0 (Nitro Compounds); 1398-61-4 (Chitin); 1L0OD70295 (2,4-dinitroanisole); 9004-34-6 (Cellulose); 9012-09-3 (cellulose triacetate); 9012-76-4 (Chitosan); NAY6KWL67F (nitroguanidine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


  2 / 2401 MEDLINE  
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[PMID]:29273563
[Au] Autor:Olas B; Brys M
[Ad] Endereço:Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland. Electronic address: beata.olas@biol.uni.lodz.pl.
[Ti] Título:Is it safe to use Acorus calamus as a source of promising bioactive compounds in prevention and treatment of cardiovascular diseases?
[So] Source:Chem Biol Interact;281:32-36, 2018 Feb 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Acorus calamus has a rich history in natural medicine, and offers many health benefits. The plant has anti-inflammatory, antimicrobial, diuretic, antiurolithiatic and other properties. Moreover, various parts, especially the rhizome and roots, are sources of a range of bioactive phenolic compounds with beneficial effects on the cardiovascular system. This review article summarizes the current knowledge of the chemical composition of different parts of A. calamus and their roles in the prevention and treatment of cardiovascular diseases. However, as no human studies have been performed, the review only includes in vitro and animal studies. The paper also briefly reviews the toxicity of A. calamus and its products for human health, especially regarding the cardiovascular system.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/prevenção & controle
Óleos Voláteis/uso terapêutico
[Mh] Termos MeSH secundário: Acorus/química
Acorus/metabolismo
Animais
Anisóis/química
Anisóis/metabolismo
Anisóis/uso terapêutico
Peso Corporal/efeitos dos fármacos
Doenças Cardiovasculares/tratamento farmacológico
Compostos de Epóxi/química
Compostos de Epóxi/metabolismo
Compostos de Epóxi/toxicidade
Seres Humanos
Hipolipemiantes/química
Hipolipemiantes/uso terapêutico
Óleos Voláteis/química
Óleos Voláteis/metabolismo
Fenóis/química
Fenóis/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anisoles); 0 (Epoxy Compounds); 0 (Hypolipidemic Agents); 0 (Oils, Volatile); 0 (Phenols); 0 (asarone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171224
[St] Status:MEDLINE


  3 / 2401 MEDLINE  
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[PMID]:29018164
[Au] Autor:Diness JG; Skibsbye L; Simó-Vicens R; Santos JL; Lundegaard P; Citerni C; Sauter DRP; Bomholtz SH; Svendsen JH; Olesen SP; Sørensen US; Jespersen T; Grunnet M; Bentzen BH
[Ad] Endereço:From the Acesion Pharma, Copenhagen, Denmark (J.G.D., R.S.-V., C.C., D.R.P.S., S.H.B., U.S.S., M.G., B.H.B.); Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (L.S., J.L.S., P.L., D.R.P.S., S.-P.O., T.J., M.G., B.H.B.); and the Heart Centre
[Ti] Título:Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca -Activated K Channels in Pigs.
[So] Source:Circ Arrhythm Electrophysiol;10(10), 2017 Oct.
[Is] ISSN:1941-3084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evidence has emerged that small-conductance Ca -activated K (SK) channels constitute a new target for treatment of atrial fibrillation (AF). SK channels are predominantly expressed in the atria as compared with the ventricles. Various marketed antiarrhythmic drugs are limited by ventricular adverse effects and efficacy loss as AF progresses. METHODS AND RESULTS: A total of 43 pigs were used for the studies. AF reversion in conscious long-term tachypaced pigs: Pigs were subjected to atrial tachypacing (7 Hz) until they developed sustained AF that could not be reverted by vernakalant 4 mg/kg (18.8±3.3 days of atrial tachypacing). When the SK channel inhibitor AP14145 was tested in these animals, vernakalant-resistant AF was reverted to sinus rhythm, and reinduction of AF by burst pacing (50 Hz) was prevented in 8 of 8 pigs. Effects on refractory period and AF duration in open chest pigs: The effects of AP14145 and vernakalant on the effective refractory periods and acute burst pacing-induced AF were examined in anaesthetized open chest pigs. Both vernakalant and AP14145 significantly prolonged atrial refractoriness and reduced AF duration without affecting the ventricular refractoriness or blood pressure in pigs subjected to 7 days atrial tachypacing, as well as in sham-operated control pigs. CONCLUSIONS: SK currents play a role in porcine atrial repolarization, and pharmacological inhibition of these with AP14145 demonstrates antiarrhythmic effects in a vernakalant-resistant porcine model of AF. These results suggest SK channel blockers as potentially interesting anti-AF drugs.
[Mh] Termos MeSH primário: Anisóis/farmacologia
Fibrilação Atrial/tratamento farmacológico
Fibrilação Atrial/fisiopatologia
Pirrolidinas/farmacologia
Canais de Potássio Ativados por Cálcio de Condutância Baixa/antagonistas & inibidores
[Mh] Termos MeSH secundário: Acetamidas
Animais
Estimulação Cardíaca Artificial
Modelos Animais de Doenças
Progressão da Doença
Técnicas de Patch-Clamp
Período Refratário Eletrofisiológico
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AP14145); 0 (Acetamides); 0 (Anisoles); 0 (Pyrrolidines); 0 (Small-Conductance Calcium-Activated Potassium Channels); 9G468C8B13 (vernakalant)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE


  4 / 2401 MEDLINE  
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[PMID]:28938019
[Au] Autor:Rahman MM; Hussain MM; Asiri AM
[Ad] Endereço:Chemistry Department, King Abdulaziz University, Jeddah, Saudi Arabia.
[Ti] Título:Fabrication of 3-methoxyphenol sensor based on Fe3O4 decorated carbon nanotube nanocomposites for environmental safety: Real sample analyses.
[So] Source:PLoS One;12(9):e0177817, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Iron oxide ornamented carbon nanotube nanocomposites (Fe3O4.CNT NCs) were prepared by a wet-chemical process in basic means. The optical, morphological, and structural characterizations of Fe3O4.CNT NCs were performed using FTIR, UV/Vis., FESEM, TEM; XEDS, XPS, and XRD respectively. Flat GCE had been fabricated with a thin-layer of NCs using a coating binding agent. It was performed for the chemical sensor development by a dependable I-V technique. Among all interfering analytes, 3-methoxyphenol (3-MP) was selective towards the fabricated sensor. Increased electrochemical performances for example elevated sensitivity, linear dynamic range (LDR) and continuing steadiness towards selective 3-MP had been observed with chemical sensor. The calibration graph found linear (R2 = 0.9340) in a wide range of 3-MP concentration (90.0 pM ~ 90.0 mM). The limit of detection and sensitivity were considered as 1.0 pM and 9×10-4 µAµM-1cm-2 respectively. The prepared of Fe3O4.CNT NCs by a wet-chemical progression is an interesting route for the development of hazardous phenolic sensor based on nanocomposite materials. It is also recommended that 3-MP sensor is exhibited a promising performances based on Fe3O4.CNT NCs by a facile I-V method for the significant applications of toxic chemicals for the safety of environmental and health-care fields.
[Mh] Termos MeSH primário: Anisóis
Técnicas Eletroquímicas/instrumentação
Poluentes Ambientais/análise
Compostos Férricos
Nanocompostos
Nanotubos de Carbono
Fenóis/análise
[Mh] Termos MeSH secundário: Anisóis/química
Calibragem
Eletricidade
Compostos Férricos/química
Modelos Lineares
Teste de Materiais
Microscopia Eletrônica de Varredura
Microscopia Eletrônica de Transmissão
Nanocompostos/química
Nanotubos de Carbono/química
Reprodutibilidade dos Testes
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Environmental Pollutants); 0 (Ferric Compounds); 0 (Nanotubes, Carbon); 0 (Phenols); 1K09F3G675 (ferric oxide); HXB7441U87 (3-hydroxyanisole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177817


  5 / 2401 MEDLINE  
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[PMID]:28869767
[Au] Autor:Elegheert J; Brigé A; Van Beeumen J; Savvides SN
[Ad] Endereço:Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Department of Biochemistry and Microbiology, Ghent University, Belgium.
[Ti] Título:Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands.
[So] Source:FEBS Lett;591(20):3391-3401, 2017 Oct.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Shewanella oneidensis, a Gram-negative γ-proteobacterium with an extensive redox capacity, possesses four old yellow enzyme (OYE) homologs. Of these, Shewanella yellow enzyme 4 (SYE4) is implicated in resistance to oxidative stress. Here, we present a series of high-resolution crystal structures for SYE4 in the oxidized and reduced states, and in complex with phenolic ligands and the nitro-aromatic explosive picric acid. The structures unmask new features, including the identification of a binding platform for long-chain hydrophobic molecules. Furthermore, we present the first structural observation of a hydride-Meisenheimer complex of picric acid with a flavoenzyme. Overall, our study exposes the binding promiscuity of SYE4 toward a variety of electrophilic substrates and is consistent with a general detoxification function for SYE4.
[Mh] Termos MeSH primário: Anisóis/química
Proteínas de Bactérias/química
Benzaldeídos/química
Cresóis/química
NADPH Desidrogenase/química
Shewanella/química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Anisóis/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Benzaldeídos/metabolismo
Sítios de Ligação
Clonagem Molecular
Cresóis/metabolismo
Cristalografia por Raios X
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Interações Hidrofóbicas e Hidrofílicas
Isoenzimas/química
Isoenzimas/genética
Isoenzimas/metabolismo
Cinética
Ligantes
Modelos Moleculares
NADPH Desidrogenase/genética
NADPH Desidrogenase/metabolismo
Oxirredução
Estresse Oxidativo
Picratos/química
Picratos/metabolismo
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Shewanella/enzimologia
Especificidade por Substrato
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Anisoles); 0 (Bacterial Proteins); 0 (Benzaldehydes); 0 (Cresols); 0 (Isoenzymes); 0 (Ligands); 0 (Picrates); 0 (Recombinant Proteins); 6HT8U7K3AM (mequinol); A49OS0F91S (picric acid); EC 1.6.99.1 (NADPH Dehydrogenase); GF3CGH8D7Z (cresol); O1738X3Y38 (4-hydroxybenzaldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12833


  6 / 2401 MEDLINE  
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[PMID]:28815595
[Au] Autor:Brindley RL; Bauer MB; Hartley ND; Horning KJ; Currie KPM
[Ad] Endereço:Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
[Ti] Título:Sigma-1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors.
[So] Source:J Neurochem;143(2):171-182, 2017 Oct.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Adrenal chromaffin cells (ACCs) are the neuroendocrine arm of the sympathetic nervous system and key mediators of the physiological stress response. Acetylcholine (ACh) released from preganglionic splanchnic nerves activates nicotinic acetylcholine receptors (nAChRs) on chromaffin cells causing membrane depolarization, opening voltage-gated Ca channels (VGCC), and exocytosis of catecholamines and neuropeptides. The serotonin transporter is expressed in ACCs and interacts with 5-HT receptors to control secretion. In addition to blocking the serotonin transporter, some selective serotonin reuptake inhibitors (SSRIs) are also agonists at sigma-1 receptors which function as intracellular chaperone proteins and can translocate to the plasma membrane to modulate ion channels. Therefore, we investigated whether SSRIs and other sigma-1 receptor ligands can modulate stimulus-secretion coupling in ACCs. Escitalopram and fluvoxamine (100 nM to 1 µM) reversibly inhibited nAChR currents. The sigma-1 receptor antagonists NE-100 and BD-1047 also blocked nAChR currents (≈ 50% block at 100 nM) as did PRE-084, a sigma-1 receptor agonist. Block of nAChR currents by fluvoxamine and NE-100 was not additive suggesting a common site of action. VGCC currents were unaffected by the drugs. Neither the increase in cytosolic [Ca ] nor the resulting catecholamine secretion evoked by direct membrane depolarization to bypass nAChRs was altered by fluvoxamine or NE-100. However, both Ca entry and catecholamine secretion evoked by the cholinergic agonist carbachol were significantly reduced by fluvoxamine or NE-100. Together, our data suggest that sigma-1 receptors do not acutely regulate catecholamine secretion. Rather, SSRIs and other sigma-1 receptor ligands inhibit secretion evoked by cholinergic stimulation because of direct block of Ca entry via nAChRs.
[Mh] Termos MeSH primário: Medula Suprarrenal/secreção
Catecolaminas/secreção
Células Cromafins/secreção
Antagonistas Nicotínicos/farmacologia
Receptores Nicotínicos/fisiologia
Receptores sigma/fisiologia
[Mh] Termos MeSH secundário: Medula Suprarrenal/citologia
Medula Suprarrenal/efeitos dos fármacos
Animais
Anisóis/farmacologia
Catecolaminas/antagonistas & inibidores
Bovinos
Células Cultivadas
Células Cromafins/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ligantes
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Propilaminas/farmacologia
Receptores sigma/agonistas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Catecholamines); 0 (Ligands); 0 (Nicotinic Antagonists); 0 (Propylamines); 0 (Receptors, Nicotinic); 0 (Receptors, sigma); 0 (sigma-1 receptor); 149409-57-4 (N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14149


  7 / 2401 MEDLINE  
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[PMID]:28811187
[Au] Autor:Gao E; Ren FF; Zou J; Yu Y; Fan HX; Zhou ZQ; Chen GD; He RR; Yao XS; Gao H
[Ad] Endereço:Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.
[Ti] Título:Chiral resolution, absolute configuration, and bioactivity of a new racemic asarone derivative from the rhizome of Acorus tatarinowii.
[So] Source:Fitoterapia;122:7-10, 2017 Oct.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A new asarone-derived racemate (1) was isolated from the rhizome of Acorus tatarinowii. The structure of 1 was established by comprehensive spectroscopic analyses, and it was successfully resolved by chiral HPLC, demonstrating that it is racemic. The absolute configurations of 1a [(-)-acortatarone A] and 1b [(+)-acortatarone A] were determined using quantum chemical calculations. Compounds 1a and 1b were the first cases of asarone derivatives with the 5,7-dialkyl-6-aryl-8-oxabicyclo[3.2.1]oct-3-en-2-one core. The α-glucosidase inhibitory and acetylcholinesterase (AChE) inhibitory activities of 1 were evaluated, and it exhibited α-glucosidase inhibitory activity with potency close to that of the positive control (acarbose).
[Mh] Termos MeSH primário: Acorus/química
Anisóis/química
Inibidores de Glicosídeo Hidrolases/química
Rizoma/química
[Mh] Termos MeSH secundário: Acetilcolinesterase/metabolismo
Anisóis/isolamento & purificação
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Estrutura Molecular
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Glycoside Hydrolase Inhibitors); 0 (asarone); EC 3.1.1.7 (Acetylcholinesterase); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170817
[St] Status:MEDLINE


  8 / 2401 MEDLINE  
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[PMID]:28665158
[Au] Autor:Deng L; Wang Y; Gong T; Sun X; Zhang ZR
[Ad] Endereço:a Key Laboratory of Drug Targeting and Delivery Systems , Sichuan University , Chengdu , China.
[Ti] Título:Dissolution and bioavailability enhancement of alpha-asarone by solid dispersions via oral administration.
[So] Source:Drug Dev Ind Pharm;43(11):1817-1826, 2017 Nov.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alpha (α)-asarone (1-propenyl-2,4,5-methoxybenzol) (ARE) has been extensively used to treat chronic obstructive pulmonary diseases (COPD), bronchial asthma, pneumonia, and epilepsy. Due to its poor solubility and bioavailability, ARE was clinically administered via intravenous injection. However, severe allergies were often reported due to the presence of solublizers in the injection formulation. In our study, we sought to explore the biopharmaceutical classification of ARE, elucidate the mechanisms behind ARE absorption, and to develop a viable formulation to improve the oral bioavailability of ARE. ARE was not a P-glycoprotein substrate, which was absorbed in the passive mode without site specificity in the gastrointestinal tract. Solid dispersions prepared using hydrophilic matrix materials such as Pluronic F68, and polyethylene glycol (PEG) of varying molecular weights (PEG4K, PEG10K, and PEG20K) were proven to significantly improve the dissolution of ARE in vitro and the oral bioavailability of ARE in rats, which represent a promising strategy for the oral administration of ARE and other BCS II compounds.
[Mh] Termos MeSH primário: Anisóis/química
Portadores de Fármacos/química
Poloxâmero/química
Polietilenoglicóis/química
[Mh] Termos MeSH secundário: Administração Oral
Animais
Disponibilidade Biológica
Varredura Diferencial de Calorimetria
Química Farmacêutica
Interações Hidrofóbicas e Hidrofílicas
Poloxâmero/farmacologia
Polietilenoglicóis/farmacologia
Ratos
Solubilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Drug Carriers); 0 (asarone); 106392-12-5 (Poloxamer); 30IQX730WE (Polyethylene Glycols)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1349783


  9 / 2401 MEDLINE  
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[PMID]:28598994
[Au] Autor:Lam KYC; Yao P; Wang H; Duan R; Dong TTX; Tsim KWK
[Ad] Endereço:Division of Life Science, Center for Chinese Medicine, the Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
[Ti] Título:Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation.
[So] Source:PLoS One;12(6):e0179077, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Acori Tatarinowii Rhizome (ATR; the dried rhizome of Acori tatarinowii Schott) is a well-known herb being used for mental disorder in China and Asia. Volatile oil is considered as the active ingredient of ATR, and asarones account for more than 90% of total volatile oil. Here, the protective effects of ATR oil and asarones, both α-asarone and ß-asarone, were probed in cultured rat astrocytes. The cyto-protective effect of ATR oil and asarones against tBHP-induced astrocyte injury was revealed, and additionally ATR oil and asarones reduced the tBHP-induced intracellular reactive oxygen species (ROS) accumulation. In parallel, the activity of anti-oxidant response element (ARE) promoter construct (pARE-Luc), being transfected in cultured astrocytes, was markedly induced by application of ATR oil and asarones. The mRNAs encoding anti-oxidant enzymes, e.g. glutathione S-transferase (GST), glutamate-cysteine ligase modulatory subunit (GCLM), glutamate-cysteine ligase catalytic subunit (GCLC) and NAD(P)H quinone oxidoreductase (NQO1) were induced by ATR oil and asarones in a dose-dependent manner. The ATR oil/asarone-induced gene expression could be mediated by Akt phosphorylation; because the applied LY294002, a phosphoinositide 3-kinase inhibitor, fully abolished the induction. These results demonstrated that α-asarone and ß-asarone could account, at least partly, the function of ATR being a Chinese medicinal herb.
[Mh] Termos MeSH primário: Acorus/química
Anisóis/farmacologia
Astrócitos/efeitos dos fármacos
Astrócitos/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Rizoma/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Fosforilação
Proteínas Proto-Oncogênicas c-akt/metabolismo
Ratos
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Antioxidants); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (asarone); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179077


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[PMID]:28499183
[Au] Autor:Bai X; Zhang T; Qu Z; Li H; Yang Z
[Ad] Endereço:College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, Hunan, PR China.
[Ti] Título:Contribution of filamentous fungi to the musty odorant 2,4,6-trichloroanisole in water supply reservoirs and associated drinking water treatment plants.
[So] Source:Chemosphere;182:223-230, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, the distribution of 2,4,6-trichloroanisole (2,4,6-TCA) in two water supply reservoirs and four associated drinking water treatment plants (DWTPs) were investigated. The 2,4,6-TCA concentrations were in the range of 1.53-2.36 ng L in water supply reservoirs and 0.76-6.58 ng L at DWTPs. To determine the contribution of filamentous fungi to 2,4,6-TCA in a full-scale treatment process, the concentrations of 2,4,6-TCA in raw water, settled water, post-filtration water, and finished water were measured. The results showed that 2,4,6-TCA levels continuously increased until chlorination, suggesting that 2,4,6-TCA could form without a chlorination reaction and fungi might be the major contributor to the 2,4,6-TCA formation. Meanwhile, twenty-nine fungal strains were isolated and identified by morphological and molecular biological methods. Of the seventeen isolated fungal species, eleven showed the capability to convert 2,4,6-trichlorophenol (2,4,6-TCP) to 2,4,6-TCA. The highest level of 2,4,6-TCA formation was carried out by Aspergillus versicolor voucher BJ1-3: 40.5% of the original 2,4,6-TCP was converted to 2,4,6-TCA. There was a significant variation in the capability of different species to generate 2,4,6-TCA. The results from the proportions of cell-free, cell-attached, and cell-bound 2,4,6-TCA suggested that 2,4,6-TCA generated by fungi was mainly distributed in their extracellular environment. In addition to 2,4,6-TCA, five putative volatile by-products were also identified by gas chromatography and mass spectrometry. These findings increase our understanding on the mechanisms involved in the formation of 2,4,6-TCA and provide insights into managing and controlling 2,4,6-TCA-related problems in drinking water.
[Mh] Termos MeSH primário: Anisóis/análise
Água Potável/análise
Fungos/química
Odorantes/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Clorofenóis
Cromatografia Gasosa
Halogenação
Abastecimento de Água/normas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Chlorophenols); 0 (Drinking Water); 31O3X41254 (2,4,6-trichloroanisole); MHS8C5BAUZ (2,4,6-trichlorophenol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE



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