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[PMID]:29394011
[Au] Autor:Saladino R; Chiocchini U; Botta G; Delfino M; Conigliaro R; Mosesso P
[Ti] Título:Free radical scavenging capacity and protective effect of natural substances in peloids from the thermal spring pool Bagnaccio (Viterbo, Italy).
[So] Source:J Cosmet Sci;67(2):71-92, 2016 Mar-Apr.
[Is] ISSN:1525-7886
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural peloids from sulfurous thermal springs are largely used in cosmetic and pelotherapy for the treatment of different dermatological conditions, including skin aging, dermatitis, and other eczemas. The beneficial effects are correlated to mineralogical and other thermal properties, as well as to the presence of natural substances with specific antioxidant activity. Few data are available for the comparison between natural peloids and synthetic (i.e., artificially maturated) muds. In this context, the natural substances and antioxidant activity of natural white mud (WM) and dark mud (DM) peloids from the sulfurous thermal spring pool Bagnaccio (Viterbo, Italy) have been studied in detail to evaluate possible relationships between physicochemical properties and therapeutic effect. A large panel of natural substances in WM and DM were characterized for the first time by ³¹P-nuclear magnetic resonance and gas chromatography associated to mass spectrometry analysis. Polar fractions of WM and DM peloids were characterized by the presence of several bioactive natural compounds, showing high antioxidant activity and DNA protective effect, as evaluated by 2,2-diphenyl-1-picrylhydrazyl assay, and hydrogen peroxide­induced DNA breakage in the alkaline comet assay. The antioxidant activity and DNA protective effect could be attributed to radical scavenging rather than a modulatory effect on the induced DNA repair, and are of order of intensity higher than that reported for synthetic muds.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Depuradores de Radicais Livres/farmacologia
Hidrocarbonetos Aromáticos/farmacologia
Fenóis/farmacologia
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Alcanos/química
Alcanos/isolamento & purificação
Alcanos/farmacologia
Alcenos/química
Alcenos/isolamento & purificação
Alcenos/farmacologia
Animais
Compostos de Bifenilo/antagonistas & inibidores
Compostos de Bifenilo/química
Células CHO
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Cricetulus
DNA/efeitos dos fármacos
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Fontes Termais
Seres Humanos
Hidrocarbonetos Aromáticos/química
Hidrocarbonetos Aromáticos/isolamento & purificação
Peróxido de Hidrogênio/antagonistas & inibidores
Peróxido de Hidrogênio/química
Itália
Espectroscopia de Ressonância Magnética
Camundongos
Terapia por Lama
Fenóis/química
Fenóis/isolamento & purificação
Picratos/antagonistas & inibidores
Picratos/química
Terpenos/química
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Alkanes); 0 (Alkenes); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Hydrocarbons, Aromatic); 0 (Phenols); 0 (Picrates); 0 (Terpenes); 9007-49-2 (DNA); BBX060AN9V (Hydrogen Peroxide); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE


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[PMID]:29342183
[Au] Autor:Nixon LJ; Morrison WR; Rice KB; Brockerhoff EG; Leskey TC; Guzman F; Khrimian A; Goldson S; Rostás M
[Ad] Endereço:Bio-Protection Research Centre, Lincoln University, Lincoln, Canterbury, New Zealand.
[Ti] Título:Identification of volatiles released by diapausing brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae).
[So] Source:PLoS One;13(1):e0191223, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The brown marmorated stink bug, Halyomorpha halys, is an agricultural and urban pest that has become widely established as an invasive species of major concern in the USA and across Europe. This species forms large aggregations when entering diapause, and it is often these aggregations that are found by officials conducting inspections of internationally shipped freight. Identifying the presence of diapausing aggregations of H. halys using their emissions of volatile organic compounds (VOCs) may be a potential means for detecting and intercepting them during international freight inspections. Headspace samples were collected from aggregations of diapausing H. halys using volatile collection traps (VCTs) and solid phase microextraction. The only compound detected in all samples was tridecane, with small amounts of (E)-2-decenal found in most samples. We also monitored the release of defensive odors, following mechanical agitation of diapausing and diapause-disrupted adult H. halys. Diapausing groups were significantly more likely to release defensive odors than diapause-disrupted groups. The predominant compounds consistently found from both groups were tridecane, (E)-2-decenal, and 4-oxo-(E)-2-hexenal, with a small abundance of dodecane. Our findings show that diapausing H. halys do release defensive compounds, and suggest that volatile sampling may be feasible to detect H. halys in freight.
[Mh] Termos MeSH primário: Heterópteros/química
Odorantes/análise
Compostos Orgânicos Voláteis/química
[Mh] Termos MeSH secundário: Aldeídos/análise
Alcanos/análise
Alcenos/análise
Animais
Diapausa
Cromatografia Gasosa-Espectrometria de Massas
Heterópteros/crescimento & desenvolvimento
Heterópteros/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 ((2E)-decenal); 0 (4-oxo-(E)-2-hexenal); 0 (Aldehydes); 0 (Alkanes); 0 (Alkenes); 0 (Volatile Organic Compounds); 11A386X1QH (n-dodecane); A3LZF0L939 (tridecane)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191223


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[PMID]:28454561
[Au] Autor:Grady SL; Malfatti SA; Gunasekera TS; Dalley BK; Lyman MG; Striebich RC; Mayhew MB; Zhou CL; Ruiz ON; Dugan LC
[Ad] Endereço:Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA. grady7@llnl.gov.
[Ti] Título:A comprehensive multi-omics approach uncovers adaptations for growth and survival of Pseudomonas aeruginosa on n-alkanes.
[So] Source:BMC Genomics;18(1):334, 2017 04 28.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Examination of complex biological systems has long been achieved through methodical investigation of the system's individual components. While informative, this strategy often leads to inappropriate conclusions about the system as a whole. With the advent of high-throughput "omic" technologies, however, researchers can now simultaneously analyze an entire system at the level of molecule (DNA, RNA, protein, metabolite) and process (transcription, translation, enzyme catalysis). This strategy reduces the likelihood of improper conclusions, provides a framework for elucidation of genotype-phenotype relationships, and brings finer resolution to comparative genomic experiments. Here, we apply a multi-omic approach to analyze the gene expression profiles of two closely related Pseudomonas aeruginosa strains grown in n-alkanes or glycerol. RESULTS: The environmental P. aeruginosa isolate ATCC 33988 consumed medium-length (C -C ) n-alkanes more rapidly than the laboratory strain PAO1, despite high genome sequence identity (average nucleotide identity >99%). Our data shows that ATCC 33988 induces a characteristic set of genes at the transcriptional, translational and post-translational levels during growth on alkanes, many of which differ from those expressed by PAO1. Of particular interest was the lack of expression from the rhl operon of the quorum sensing (QS) system, resulting in no measurable rhamnolipid production by ATCC 33988. Further examination showed that ATCC 33988 lacked the entire lasI/lasR arm of the QS response. Instead of promoting expression of QS genes, ATCC 33988 up-regulates a small subset of its genome, including operons responsible for specific alkaline proteases and sphingosine metabolism. CONCLUSION: This work represents the first time results from RNA-seq, microarray, ribosome footprinting, proteomics, and small molecule LC-MS experiments have been integrated to compare gene expression in bacteria. Together, these data provide insights as to why strain ATCC 33988 is better adapted for growth and survival on n-alkanes.
[Mh] Termos MeSH primário: Alcanos/farmacologia
Biologia Computacional/métodos
Pseudomonas aeruginosa/efeitos dos fármacos
[Mh] Termos MeSH secundário: Perfilação da Expressão Gênica
Glicolipídeos/metabolismo
Pseudomonas aeruginosa/citologia
Pseudomonas aeruginosa/genética
Pseudomonas aeruginosa/metabolismo
Percepção de Quorum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Alkanes); 0 (Glycolipids); 0 (rhamnolipid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-017-3708-4


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[PMID]:28451837
[Au] Autor:Cao W; Li H; Luo J; Yin J; Wan Y
[Ad] Endereço:State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.
[Ti] Título:High-level productivity of α,ω-dodecanedioic acid with a newly isolated Candida viswanathii strain.
[So] Source:J Ind Microbiol Biotechnol;44(8):1191-1202, 2017 Aug.
[Is] ISSN:1476-5535
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:α,ω-Dicarboxylic acids (DC) are versatile chemical intermediates with different chain lengths, which are well-known as polymer building block. In this work, a new strain with high productivity of DC was isolated from oil-contaminated soil. Based on the morphology and phylogenetic analyses of the internal transcribed spacer sequences, it was characterized as Candida viswanathii. It was found that the contribution of carbon flux to the cell growth and DC production from n-dodecane could be regulated by the sucrose and yeast extract concentrations in the medium, and besides the broth pH, a suitable proportioning of sucrose and yeast extract was the key to achieve the optimal transition from cell growth phase to DC production phase. By optimizing culture conditions in a 7.5-L bioreactor, a higher DC productivity of 1.59 g·L h with a corresponding concentration of 181.6 g/L was obtained. After the purification of DC from the culture, the results from gas chromatography-mass spectrometry, infrared spectroscopy and H-NMR showed that α,ω-dodecanedioic acid (DC ) was the major product of C. viswanathii ipe-1 using pure n-dodecane as substrate. For the first time, we reported that a high productivity of DC could be produced by C. viswanathii.
[Mh] Termos MeSH primário: Candida/metabolismo
Ácidos Dicarboxílicos/metabolismo
[Mh] Termos MeSH secundário: Alcanos/química
Reatores Biológicos
Candida/classificação
Meios de Cultura/química
Cromatografia Gasosa-Espectrometria de Massas
Concentração de Íons de Hidrogênio
Filogenia
Sacarose/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Culture Media); 0 (Dicarboxylic Acids); 11A386X1QH (n-dodecane); 57-50-1 (Sucrose); 978YU42Q6I (dodecanedioic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s10295-017-1948-6


  5 / 7245 MEDLINE  
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[PMID]:28834404
[Au] Autor:Gu M; Xia Q; Liu X; Guo Y; Wang Y
[Ad] Endereço:Shanghai Key Laboratory of Functional Materials Chemistry and, Research Institute of Industrial Catalysis, School of Chemistry and Molecular Engineering, East China University of Science of Technology, No. 130 Meilong Road, Shanghai, 200237, P.R. China.
[Ti] Título:Synthesis of Renewable Lubricant Alkanes from Biomass-Derived Platform Chemicals.
[So] Source:ChemSusChem;10(20):4102-4108, 2017 Oct 23.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The catalytic synthesis of liquid alkanes from renewable biomass has received tremendous attention in recent years. However, bio-based platform chemicals have not to date been exploited for the synthesis of highly branched lubricant alkanes, which are currently produced by hydrocracking and hydroisomerization of long-chain n-paraffins. A selective catalytic synthetic route has been developed for the production of highly branched C alkanes as lubricant base oil components from biomass-derived furfural and acetone through a sequential four-step process, including aldol condensation of furfural with acetone to produce a C double adduct, selective hydrogenation of the adduct to a C ketone, followed by a second condensation of the C ketone with furfural to generate a C aldol adduct, and finally hydrodeoxygenation to give highly branched C alkanes in 50.6 % overall yield from furfural. This work opens a general strategy for the synthesis of high-quality lubricant alkanes from renewable biomass.
[Mh] Termos MeSH primário: Alcanos/química
Alcanos/síntese química
Biomassa
Lubrificantes/química
Lubrificantes/síntese química
[Mh] Termos MeSH secundário: Acetona/química
Técnicas de Química Sintética
Furaldeído/química
Hidrogenação
Oxigênio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Lubricants); 1364PS73AF (Acetone); DJ1HGI319P (Furaldehyde); S88TT14065 (Oxygen)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701200


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[PMID]:28739157
[Au] Autor:Liu Q; Cai X; Yang D; Chen Y; Wang Y; Shao L; Wang MW
[Ad] Endereço:School of Pharmacy, Fudan University, Shanghai 201203, China; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; The National Center for Drug Screening, Shanghai 201203, China.
[Ti] Título:Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors.
[So] Source:Bioorg Med Chem;25(17):4579-4594, 2017 Sep 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of cycloalkyl substituted analogues of the natural product sinefungin lacking the amino-acid moiety was designed and synthesized. Two stereoisomers (6-R and 6-S) were separated and their bioactivities examined against EHMT1/2. Of which, compound 14d showed an inhibitory activity against EHMT1/2 (88.9%, IC =21.8µM for EHMT1 and 77.6%, IC =39.6µM for EHMT2, respectively) similar to that of sinefungin (100.0%, IC =28.4µM for EHMT1 and 79.5%, IC =30.1µM for EHMT2, respectively). Further studies against other methyltransferases such as PRMT1 showed no activity except that 12d displayed about 20% inhibition.
[Mh] Termos MeSH primário: Adenosina/análogos & derivados
Inibidores Enzimáticos/química
Histona-Lisina N-Metiltransferase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Adenosina/química
Adenosina/metabolismo
Adenosina/toxicidade
Alcanos/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Inibidores Enzimáticos/metabolismo
Inibidores Enzimáticos/toxicidade
Antígenos de Histocompatibilidade/metabolismo
Histona-Lisina N-Metiltransferase/metabolismo
Seres Humanos
Concentração Inibidora 50
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (9-(5',6',7'-deoxy-6'-amine-7'-cyclopropylheptafuranoside-1')adenine); 0 (Alkanes); 0 (Enzyme Inhibitors); 0 (Histocompatibility Antigens); EC 2.1.1.- (EHMT1 protein, human); EC 2.1.1.43 (EHMT2 protein, human); EC 2.1.1.43 (Histone-Lysine N-Methyltransferase); K72T3FS567 (Adenosine); W2U467CIIL (sinefungin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28701654
[Au] Autor:Asakawa Y; Tomiyama K; Sakurai K; Kawakami Y; Yaguchi Y
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:Volatile Compounds from the Different Organs of Houttuynia cordata and Litsea cubeba (L. citriodora).
[So] Source:J Oleo Sci;66(8):889-895, 2017 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The volatile compounds obtained from the different organs of Houttuynia cordata (Saururaceae) and Litsea cubeba (Lauraceae) were analyzed by Gas Chromatography/Mass Spectrometry (GC/MS), Headspace Solid Phase Micro Extraction-Gas Chromatography/Mass Spectrometry (HS-SPME-GC/MS), and GC/olfactometry (GC/O). The major component of all parts of H. cordata is assigned as 4-tridecanone. Each organ produces myrcene as the major monoterpenoid. The major monoterpene in the rhizomes and roots was ß-pinene instead of myrcene. 1-Decanal which was responsible for the unpleasant odor of this plant, was the predominant polyketide in both leaves and stems. The presence of 1-decanal was very poor in flowers, stem collected in summer, rhizomes, and roots. GC/MS analyses were very simple in case of the crude extracts of flowers. The content of sesquiterpenoids was extremely poor. (8Z)-Heptadecene, geranial, and neral were detected as the major components in Litsea cubeba. Odor-contributing components by GC/O analysis of the ether extract of the fresh flowers of L. cubeba were neral and geranial which played an important role in sweet-lemon fragrance of the flowers. The role of a high content of (8Z)-heptadecene was still unknown but it might play a significant role in the dispersion of the volatile monoterpene hydrocarbons and aldehydes. The flower volatiles of the Japanese L. cubeba were chemically quite different from those of the Chinese same species.
[Mh] Termos MeSH primário: Houttuynia/química
Litsea/química
Estruturas Vegetais
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Alcanos/análise
Alcenos/análise
Compostos Bicíclicos com Pontes/análise
Álcoois Graxos/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Litsea/anatomia & histologia
Monoterpenos/análise
Olfatometria
Policetídeos/análise
Sesquiterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Alkenes); 0 (Bridged Bicyclo Compounds); 0 (Fatty Alcohols); 0 (Monoterpenes); 0 (Polyketides); 0 (Sesquiterpenes); 0 (Volatile Organic Compounds); 3M39CZS25B (myrcene); 4MS8VHZ1HJ (beta-pinene); 89V4LX791F (n-decyl alcohol); A3LZF0L939 (tridecane); H7C0J39XUM (heptadecane); T7EU0O9VPP (citral)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17049


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[PMID]:28672689
[Au] Autor:Esquinas N; Rodríguez-Valdés E; Márquez G; Gallego JLR
[Ad] Endereço:Environmental Technology, Biotechnology & Geochemistry Group and INDUROT, University of Oviedo, C/Gonzalo Gut. S/N, 33600 Mieres, Asturias, Spain; Center for Research in Sustainable Chemistry - CIQSO, University of Huelva, Campus El Carmen, 21007 Huelva, Spain.
[Ti] Título:Diagnostic ratios for the rapid evaluation of natural attenuation of heavy fuel oil pollution along shores.
[So] Source:Chemosphere;184:1089-1098, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Marine oil spills are typically followed by complex clean-up and monitoring operations of the shorelines affected. In this regard, determination of the changes in the chemical composition of the spilled product is crucial for evaluation purposes. The "GC-MS fingerprint" approach requires the identification of several key parameters in order to differentiate between weathering processes. In this context, we performed a 900-day study (eight sampling campaigns) of natural attenuation on a rocky shore affected by a heavy fuel oil spill. The residues coating the rocks were studied by extraction, separation and evaluation of SARA fractions, followed by GC-MS analysis for saturates and aromatics. The results identified a group of diagnostic ratios with irregular capabilities to differentiate between volatilization, photodegradation, and biodegradation (using n-alkanes, isoprenoids and PAHs), while a second group of primarily stable ratios (using dibenzothiphenes, tricyclics and hopanes) was also obtained. Notably, this is the first time that some of these ratios have been used for marine spill monitoring purposes. The ratios were applied not only to evaluate weathering at the study site, but also to obtain a comparison with the degradation of floating oil slicks-a demonstration that weathering of the latter was quicker than that of oil on the shore rocks. Additionally, Pyrolysis-GC-MS analysis of the asphaltene fraction of residues coating the rocks revealed moderate changes in the composition of this initially recalcitrant fraction. These changes were consistent with those found in the proportion of resins and asphaltene fractions over time.
[Mh] Termos MeSH primário: Biodegradação Ambiental
Monitoramento Ambiental
Óleos Combustíveis/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Alcanos/análise
Cromatografia Gasosa-Espectrometria de Massas
Petróleo/análise
Poluição por Petróleo/análise
Hidrocarbonetos Aromáticos Policíclicos/análise
Terpenos/análise
Tempo (Meteorologia)
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Fuel Oils); 0 (Petroleum); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Terpenes); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


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[PMID]:28662387
[Au] Autor:Cao W; Liu B; Luo J; Yin J; Wan Y
[Ad] Endereço:State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
[Ti] Título:α, ω-Dodecanedioic acid production by Candida viswanathii ipe-1 with co-utilization of wheat straw hydrolysates and n-dodecane.
[So] Source:Bioresour Technol;243:179-187, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Candida viswanathii ipe-1 was used to produce α, ω-dodecanedioic acid (DC ), which showed capability to ferment xylose and glucose simultaneously, while arabinose utilization was less efficient. A low concentration of furfural enhanced cell growth, and the addition of 4.0g/L sodium acetate largely increased DC production. It indicated that detoxification of the wheat straw hydrolysates was not necessary for the biosynthesis of DC . Based on the promising features of our strain, an efficient process was developed to produce DC from co-utilization of wheat straw hydrolysates and n-dodecane. Using this process, 129.7g/L DC with a corresponding productivity of 1.13g·L ·h could be produced, which was increased by 40.0% compared with a sole carbon of glucose. The improved DC yield by the co-utilization of wheat straw hydrolysates and n-dodecane using C. viswanathii ipe-1 demonstrates the great potential of using biomass as a feedstock in the production of DC .
[Mh] Termos MeSH primário: Candida
Ácidos Dicarboxílicos
Triticum
[Mh] Termos MeSH secundário: Alcanos
Fermentação
Hidrólise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Dicarboxylic Acids); 11A386X1QH (n-dodecane); 978YU42Q6I (dodecanedioic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE


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[PMID]:28662172
[Au] Autor:Zhou X; Xing X; Hou J; Liu J
[Ad] Endereço:School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Quantitative proteomics analysis of proteins involved in alkane uptake comparing the profiling of Pseudomonas aeruginosa SJTD-1 in response to n-octadecane and n-hexadecane.
[So] Source:PLoS One;12(6):e0179842, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:While many data are available on genes encoding proteins for degradation of hydrocarbons in bacteria, the impact of alkane on transporter protein expression is unclear. Pseudomonas aeruginosa SJTD-1 is a strain that can consume medium- and long-chain n-alkanes. In order to study the proteins involved in n-octadecane uptake, we use iTRAQ and label free comparative proteomics analysis to identify the proteins of alkane uptake in response to n-octadecane (C18) comparing with n-hexadecane (C16) in P. aeruginosa SJTD-1. A total of 1102 and 1249 proteins were identified by iTRAQ-based and label free quantitative methodologies, respectively. By application of 1.5 (iTRAQ) or 2-fold (label free) for upregulated and 0.65 (iTRAQ) or 0.5-fold (label free) for downregulated cutoff values, 91 and 99 proteins were found to be differentially expressed comparing SJTD-1 cultivated on C18 with C16 respectively. There are six proteins with the common differential expression by iTRAQ and label free-based methods. Results of bioinformational analysis suggested the involvement of bacterial chemotaxis in responds to C18. Additionally, quantitative reverse transcriptase PCR (qRT-PCR) results confirmed C18-induced change in levels of FleQ, FliC, NirS, FadL and FadD proteins and the role of the proteins in n-octadecane uptake was further discussed in P. aeruginosa. In conclusion, results of the present study provided information about possible target-related proteins of bacterial chemotaxis, swimming performance, alkane transport to stimulus of n-ctadecane rather than n-hexadecane in P. aeruginosa SJTD-1.
[Mh] Termos MeSH primário: Alcanos/metabolismo
Proteínas de Bactérias/metabolismo
Proteômica
Pseudomonas aeruginosa/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Biodegradação Ambiental
Cromatografia de Fase Reversa/métodos
Mapas de Interação de Proteínas
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkanes); 0 (Bacterial Proteins); F8Z00SHP6Q (n-hexadecane); N102P6HAIU (octadecane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179842



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