Base de dados : MEDLINE
Pesquisa : D02.455.326.146.720 [Categoria DeCS]
Referências encontradas : 678 [refinar]
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[PMID]:28732585
[Au] Autor:Prasad S; Roy I
[Ad] Endereço:Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Punjab 160062, India.
[Ti] Título:Obtaining a high activity subtilisin preparation by controlled thermal stress in n-octane.
[So] Source:Anal Biochem;534:86-90, 2017 Oct 01.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The use of enzymes in organic solvents has considerably widened their repertoire of applications. Such low water containing media also offer the possibility of carrying out enzymatic reactions at higher temperatures and enhancing reaction yields. The utility of such preparations is limited by the damage caused to the protein structure during freeze-drying. This work investigates the result of exposing the proteolytic enzyme subtilisin to high temperature in low water containing n-octane on its activity in aqueous and non-aqueous media. Exposing subtilisin at 90 °C for 5 h led to 18-fold improvement in its transesterification activity even at the normal assay temperature (37 °C) when compared with the untreated enzyme. The use of n-octane as the reaction medium was important as it helped to retain the three-dimensional architecture of the enzyme and should be considered while designing strategies for obtaining high activity preparations of other enzymes. Structural analysis using differential scanning fluorimetry showed that the enzyme lost its structure after heating in aqueous medium but retained it when heated in organic solvent. The simplicity and general applicability of the strategy should make it useful for obtaining highly active preparations of other enzymes as well.
[Mh] Termos MeSH primário: Octanos/química
Subtilisina/metabolismo
Temperatura Ambiente
[Mh] Termos MeSH secundário: Estabilidade Enzimática
Subtilisina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Octanes); EC 3.4.21.62 (Subtilisin); X1RV0B2FJV (octane)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28363936
[Au] Autor:Scott EE
[Ad] Endereço:From the Departments of Medicinal Chemistry, Pharmacology, and Biophysics, University of Michigan, Ann Arbor, Michigan 48109 scottee@umich.edu.
[Ti] Título:ω- (ω-1)-hydroxylation: Cytochrome P450 4B1 sterics make the call.
[So] Source:J Biol Chem;292(13):5622-5623, 2017 Mar 31.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many family 4 cytochrome P450s play key roles in fatty acid hydroxylation at the terminal, or ω, carbon, but the mechanistic basis for this energetically disfavored regiostereochemistry has been less clear. A co-crystal structure of the rabbit family 4 enzyme CYP4B1 with its substrate octane reveals that the propensity for ω-hydroxylation is orchestrated by active-site sterics, partially mediated by an unusual heme-polypeptide ester bond.
[Mh] Termos MeSH primário: Hidrocarboneto de Aril Hidroxilases/química
Hidrocarboneto de Aril Hidroxilases/metabolismo
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Cristalografia por Raios X
Ácidos Graxos/metabolismo
Hidroxilação
Octanos/química
Octanos/metabolismo
Coelhos
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Octanes); EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases); EC 1.14.14.1 (cytochrome P-450 CYP4B1); X1RV0B2FJV (octane)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.H117.775494


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[PMID]:28259740
[Au] Autor:Soper AK; Edler KJ
[Ad] Endereço:STFC Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, UK. Electronic address: alan.soper@stfc.ac.uk.
[Ti] Título:Coarse-grained empirical potential structure refinement: Application to a reverse aqueous micelle.
[So] Source:Biochim Biophys Acta;1861(6):1652-1660, 2017 06.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Conventional atomistic computer simulations, involving perhaps up to 10 atoms, can achieve length-scales on the order of a few 10s of nm. Yet many heterogeneous systems, such as colloids, nano-structured materials, or biological systems, can involve correlations over distances up 100s of nm, perhaps even 1µm in some instances. For such systems it is necessary to invoke coarse-graining, where single atoms are replaced by agglomerations of atoms, usually represented as spheres, in order for the simulation to be performed within a practical computer memory and time scale. Small angle scattering and reflectivity measurements, both X-ray and neutron, are routinely used to investigate structure in these systems, and traditionally the data have been interpreted in terms of discrete objects, such as spheres, sheets, and cylinders, and combinations thereof. Here we combine the coarse-grained computer simulation approach with neutron small angle scattering to refine the structure of a heterogeneous system, in the present case a reverse aqueous micelle of sodium-dioctyl sulfosuccinate (AOT) and iso-octane. The method closely follows empirical potential structure refinement and involves deriving an empirical interaction potential from the scattering data. As in traditional coarse-grained methods, individual atoms are replaced by spherical density profiles, which, unlike real atoms, can inter-penetrate to a significant extent. The method works over an arbitrary range of length-scales, but is limited to around 2 orders of magnitude in distance above a specified dimension. The smallest value for this dimension is of order 1nm, but the largest dimension is arbitrary. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editor: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.
[Mh] Termos MeSH primário: Simulação por Computador
Ácido Dioctil Sulfossuccínico/química
Modelos Químicos
Octanos/química
[Mh] Termos MeSH secundário: Micelas
Difração de Nêutrons
Tamanho da Partícula
Espalhamento a Baixo Ângulo
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Micelles); 0 (Octanes); 10041-19-7 (Dioctyl Sulfosuccinic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE


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[PMID]:28169167
[Au] Autor:Iwuagwu C; King D; McDonald IM; Cook J; Zusi FC; Hill MD; Mate RA; Fang H; Knox R; Gallagher L; Post-Munson Amy Easton D; Miller R; Benitex Y; Siuciak J; Lodge N; Zaczek R; Morgan D; Bristow L; Macor JE; Olson RE
[Ad] Endereço:Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. Electronic address: christiana.iwuagwu@bms.com.
[Ti] Título:Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.
[So] Source:Bioorg Med Chem Lett;27(5):1261-1266, 2017 Mar 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotinergic 5HT receptor. (1'S,3'R,4'S)-N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine, a potent and selective α7 nAChR partial agonist, was demonstrated to improve cognition in the mouse novel object recognition (NOR) model of episodic memory.
[Mh] Termos MeSH primário: Desenho de Drogas
Octanos/síntese química
Pirimidinas/síntese química
Compostos de Espiro/síntese química
Receptor Nicotínico de Acetilcolina alfa7/agonistas
[Mh] Termos MeSH secundário: Animais
Cognição/efeitos dos fármacos
Transtornos Cognitivos/tratamento farmacológico
Modelos Animais de Doenças
Camundongos
Estrutura Molecular
Octanos/química
Octanos/farmacologia
Pirimidinas/química
Pirimidinas/farmacologia
Compostos de Espiro/química
Compostos de Espiro/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (N-(6-phenylpyrimidin-4-yl)-4H-1'-azaspiro(oxazole-5,3'-bicyclo(2.2.2)octan)-2-amine); 0 (Octanes); 0 (Pyrimidines); 0 (Spiro Compounds); 0 (alpha7 Nicotinic Acetylcholine Receptor)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE


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[PMID]:28167536
[Au] Autor:Hsu MH; Baer BR; Rettie AE; Johnson EF
[Ad] Endereço:From the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037 and.
[Ti] Título:The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.
[So] Source:J Biol Chem;292(13):5610-5621, 2017 Mar 31.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:P450 family 4 fatty acid ω-hydroxylases preferentially oxygenate primary C-H bonds over adjacent, energetically favored secondary C-H bonds, but the mechanism explaining this intriguing preference is unclear. To this end, the structure of rabbit P450 4B1 complexed with its substrate octane was determined by X-ray crystallography to define features of the active site that contribute to a preference for ω-hydroxylation. The structure indicated that octane is bound in a narrow active-site cavity that limits access of the secondary C-H bond to the reactive intermediate. A highly conserved sequence motif on helix I contributes to positioning the terminal carbon of octane for ω-hydroxylation. Glu-310 of this motif auto-catalytically forms an ester bond with the heme 5-methyl, and the immobilized Glu-310 contributes to substrate positioning. The preference for ω-hydroxylation was decreased in an E310A mutant having a shorter side chain, but the overall rates of metabolism were retained. E310D and E310Q substitutions having longer side chains exhibit lower overall rates, likely due to higher conformational entropy for these residues, but they retained high preferences for octane ω-hydroxylation. Sequence comparisons indicated that active-site residues constraining octane for ω-hydroxylation are conserved in family 4 P450s. Moreover, the heme 7-propionate is positioned in the active site and provides additional restraints on substrate binding. In conclusion, P450 4B1 exhibits structural adaptations for ω-hydroxylation that include changes in the conformation of the heme and changes in a highly conserved helix I motif that is associated with selective oxygenation of unactivated primary C-H bonds.
[Mh] Termos MeSH primário: Hidrocarboneto de Aril Hidroxilases/química
Sequência Conservada
Octanos/química
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Cristalografia por Raios X
Heme/química
Heme/metabolismo
Hidroxilação
Conformação Proteica
Coelhos
Relação Estrutura-Atividade
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Octanes); 42VZT0U6YR (Heme); EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases); EC 1.14.14.1 (cytochrome P-450 CYP4B1); X1RV0B2FJV (octane)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.775494


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[PMID]:28140664
[Au] Autor:Zhou HC; Yang L; Guo RZ; Li J
[Ad] Endereço:a Acupuncture and Moxibustion Department , The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine , Harbin 150009 , China.
[Ti] Título:Phenolic acid derivatives with neuroprotective effect from the aqueous extract of Clerodendranthus spicatus.
[So] Source:J Asian Nat Prod Res;19(10):974-980, 2017 Oct.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures were elucidated on the basis of 1D and 2D NMR, MS, and CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in the previously isolated phenolic acid derivatives. The two compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells, and the result showed that compounds 1 and 2 displayed moderate neuroprotective activity with the IC values of 17.4 and 21.3 µM, respectively.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/isolamento & purificação
Hidroxibenzoatos/isolamento & purificação
Lamiaceae/química
Fármacos Neuroprotetores/isolamento & purificação
[Mh] Termos MeSH secundário: Morte Celular/efeitos dos fármacos
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Hidroxibenzoatos/química
Hidroxibenzoatos/farmacologia
Concentração Inibidora 50
Estrutura Molecular
Fármacos Neuroprotetores/química
Fármacos Neuroprotetores/farmacologia
Ressonância Magnética Nuclear Biomolecular
Octanos
Oxidopamina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Hydroxybenzoates); 0 (Neuroprotective Agents); 0 (Octanes); 0 (helisterculin C); 0 (helisterculin D); 29656-58-4 (phenolic acid); 8HW4YBZ748 (Oxidopamine); X1RV0B2FJV (octane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1277707


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[PMID]:27939633
[Au] Autor:Mohamad Shahimin MF; Siddique T
[Ad] Endereço:Department of Renewable Resources, University of Alberta, Edmonton, AB, Canada. Electronic address: mohdfaidz@unimap.edu.my.
[Ti] Título:Sequential biodegradation of complex naphtha hydrocarbons under methanogenic conditions in two different oil sands tailings.
[So] Source:Environ Pollut;221:398-406, 2017 Feb.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Methane emissions in oil sands tailings ponds are sustained by anaerobic biodegradation of unrecovered hydrocarbons. Naphtha (primarily C -C ; n- iso- and cycloalkanes) is commonly used as a solvent during bitumen extraction process and its residue escapes to tailings ponds during tailings deposition. To investigate biodegradability of hydrocarbons in naphtha, mature fine tailings (MFT) collected from Albian and CNRL tailings ponds were amended with CNRL naphtha at ∼0.2 wt% (∼2000 mg L ) and incubated under methanogenic conditions for ∼1600 d. Microbial communities in both MFTs started metabolizing naphtha after a lag phase of ∼100 d. Complete biodegradation/biotransformation of all n-alkanes (except partial biodegradation of n-octane in CNRL MFT) followed by major iso-alkanes (2-methylpentane, 3-methylhexane, 2- and 4-methylheptane, iso-nonanes and 2-methylnonane) and a few cycloalkanes (derivatives of cyclopentane and cyclohexane) was observed during the incubation. 16S rRNA gene pyrosequencing showed dominance of Peptococcaceae and Anaerolineaceae in Albian MFT and Anaerolineaceae and Syntrophaceae in CNRL MFT bacterial communities with co-domination of Methanosaetaceae and "Candidatus Methanoregula" in archaeal populations during active biodegradation of hydrocarbons. The findings extend the known range of hydrocarbons susceptible to methanogenic biodegradation in petroleum-impacted anaerobic environments and help refine existing kinetic model to predict greenhouse gas emissions from tailings ponds.
[Mh] Termos MeSH primário: Alcanos/análise
Monitoramento Ambiental
Poluentes Ambientais/metabolismo
Hidrocarbonetos/análise
Campos de Petróleo e Gás
[Mh] Termos MeSH secundário: Alcanos/metabolismo
Archaea/metabolismo
Biodegradação Ambiental
Poluentes Ambientais/análise
Hexanos/análise
Hexanos/metabolismo
Hidrocarbonetos/metabolismo
Metano/metabolismo
Octanos
Pentanos/análise
Pentanos/metabolismo
Petróleo/metabolismo
Tanques
RNA Ribossômico 16S
Microbiologia da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-methylhexane); 0 (Alkanes); 0 (Environmental Pollutants); 0 (Hexanes); 0 (Hydrocarbons); 0 (Octanes); 0 (Pentanes); 0 (Petroleum); 0 (RNA, Ribosomal, 16S); 49IB0U6MLD (2-methylpentane); 8052-42-4 (asphalt); O3L624621X (naphtha); OP0UW79H66 (Methane); T9W3VH6G10 (nonane); X1RV0B2FJV (octane)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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Landers, Richard
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[PMID]:27026546
[Au] Autor:Fujimoto TM; Ponczek M; Rochetto UL; Landers R; Tomaz E
[Ad] Endereço:Faculty of Chemical Engineering, University of Campinas-UNICAMP, Av. Albert Einstein, 500, Campinas, 13083-852, SP, Brazil. taniafujimoto@gmail.com.
[Ti] Título:Photocatalytic oxidation of selected gas-phase VOCs using UV light, TiO and TiO /Pd.
[So] Source:Environ Sci Pollut Res Int;24(7):6390-6396, 2017 Mar.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Heterogeneous photocatalytic oxidation systems using titanium dioxide (TiO ) have been extensively studied for the removal of several volatile organic compounds (VOCs). The addition of noble metals such as palladium on TiO may improve photocatalytic activity by increasing charge separation efficiency. In this work, palladium was impregnated on TiO and the efficiency of the new catalyst was tested and compared with that of pure TiO . Pd was impregnated on TiO by the reduction method, using NaBH , and was characterized by XRD, XPS, UV-Vis, and H chemisorption. The photocatalytic tests were performed in an annular coated-wall reactor using octane, isooctane, n-hexane, and cyclohexane at inlet concentrations varying from 100 to 120 ppmv. Compared with pure TiO film, the photocatalytic activity of TiO impregnated with 1 wt% of palladium was improved. All the aforementioned analytical techniques confirmed the presence of Pd incorporated into the structure of TiO and the conversion rates were studied in a broad range of residence times, yielding up to 90 % or higher rates in 40 s of residence time, thus underscoring the relevant contribution of the technology.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/isolamento & purificação
Paládio/química
Titânio/química
Raios Ultravioleta
[Mh] Termos MeSH secundário: Adsorção
Catálise
Hexanos/isolamento & purificação
Octanos/isolamento & purificação
Oxirredução
Processos Fotoquímicos
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Hexanes); 0 (Octanes); 15FIX9V2JP (titanium dioxide); 2DDG612ED8 (n-hexane); 5TWQ1V240M (Palladium); D1JT611TNE (Titanium); X1RV0B2FJV (octane)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160331
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6494-7


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[PMID]:26704938
[Au] Autor:Wang S; Liu Z
[Ad] Endereço:Institute of Chemical and Engineering Sciences, Jurong Island, 627833 Singapore.
[Ti] Título:Oxygenation cascade analysis in conversion of n-octane catalyzed by cytochrome P450 CYP102A3 mutants at the P331 site.
[So] Source:Biotechnol Appl Biochem;64(1):14-19, 2017 Jan.
[Is] ISSN:1470-8744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To improve the hydroxylation efficiency of cytochrome P450 CYP102A3 to substrate n-octane, a previously reported triple-mutant F88V/S188Q/A330V with altered regioselectivity was selected and site-saturation mutagenesis was performed at its P331 site, which is adjacent to one of the active sites A330. Using whole-cell biotransformations to analyze the created mutants, four better mutants P331A, P331T, P331S, and P331V were achieved and exhibited significantly improved conversion rates toward n-octane, which are 33%, 33%, 22% and 28%, respectively, whereas the activity of P331R was greatly reduced and P331K gave almost zero conversion of n-octane. Besides the main product octanols, different octanones and 1,7-octanediol were also detected for some of the mutants. The above results demonstrated that the P331 site of CYP102A3 also plays an important role in the n-octane oxidation and CYP102A3 is a functionally flexible biocatalyst that can be optimized for a variety of industrial applications.
[Mh] Termos MeSH primário: Bacillus subtilis/enzimologia
Proteínas de Bactérias/química
Sistema Enzimático do Citocromo P-450/química
Mutação
Octanos/química
[Mh] Termos MeSH secundário: Bacillus subtilis/genética
Proteínas de Bactérias/genética
Domínio Catalítico
Sistema Enzimático do Citocromo P-450/genética
Oxirredução
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Octanes); 0 (Recombinant Proteins); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.14.14.1 (CYP102A3 protein, Bacillus subtilis); X1RV0B2FJV (octane)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170223
[Lr] Data última revisão:
170223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151226
[St] Status:MEDLINE
[do] DOI:10.1002/bab.1472


  10 / 678 MEDLINE  
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[PMID]:27563869
[Au] Autor:Zielinski W; Kukawka R; Maciejewski H; Smiglak M
[Ad] Endereço:Poznan Science and Technology Park, Adam Mickiewicz University Foundation, 46 Rubiez ST., 61-612 Poznan, Poland. witar6@gmail.com.
[Ti] Título:Ionic Liquids as Solvents for Rhodium and Platinum Catalysts Used in Hydrosilylation Reaction.
[So] Source:Molecules;21(9), 2016 Aug 24.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A group of imidazolium and pyridinium based ionic liquids has been synthetized, and their ability to dissolve and activate the catalysts used in hydrosilylation reaction of 1-octane and 1,1,1,3,5,5,5-heptamethyltrisiloxane was investigated. An organometallic catalyst as well as inorganic complexes of platinum and rhodium dissolved in ionic liquids were used, forming liquid solutions not miscible with the substrates or with the products of the reaction. The results show that application of such a simple biphasic catalytic system enables reuse of ionic liquid phase with catalysts in multiple reaction cycles reducing the costs and decreasing the amount of catalyst needed per mole of product.
[Mh] Termos MeSH primário: Líquidos Iônicos/química
Octanos/química
Platina/química
Ródio/química
Siloxanas/química
[Mh] Termos MeSH secundário: Catálise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ionic Liquids); 0 (Octanes); 0 (Siloxanes); 49DFR088MY (Platinum); DMK383DSAC (Rhodium); X1RV0B2FJV (octane)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE



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