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  1 / 3096 MEDLINE  
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[PMID]:29313537
[Au] Autor:Moyer P; Smith MD; Abdoulmoumine N; Chmely SC; Smith JC; Petridis L; Labbé N
[Ad] Endereço:Center for Renewable Carbon, University of Tennessee, 2506 Jacob Drive, Knoxville, TN 37996-4542, USA. nlabbe@utk.edu.
[Ti] Título:Relationship between lignocellulosic biomass dissolution and physicochemical properties of ionic liquids composed of 3-methylimidazolium cations and carboxylate anions.
[So] Source:Phys Chem Chem Phys;20(4):2508-2516, 2018 Jan 24.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate ([EMIM]Acetate) has been widely used for biomass processing, i.e., to pretreat, activate, or fractionate lignocellulosic biomass to produce soluble sugars and lignin. However, this IL does not achieve high biomass solubility, therefore minimizing the efficiency of biomass processing. In this study, [EMIM]Acetate and three other ILs composed of different 3-methylimidazolium cations and carboxylate anions ([EMIM]Formate, 1-allyl-3-methylimidazolium ([AMIM]) formate, and [AMIM]Acetate) were analyzed to relate their physicochemical properties to their biomass solubility performance. While all four ILs are able to dissolve hybrid poplar under fairly mild process conditions (80 °C and 100 RPM stirring), [AMIM]Formate and [AMIM]Acetate have particularly increased biomass solubility of 40 and 32%, respectively, relative to [EMIM]Acetate. Molecular dynamics simulations suggest that strong interactions between IL and specific plant biopolymers may contribute to this enhanced solubilization, as the calculated second virial coefficients between ILs and hemicellullose are most favorable for [AMIM]Formate, matching the trend of the experimental solubility measurements. The simulations also reveal that the interactions between the ILs and hemicellulose are an important factor in determining the overall biomass solubility, whereas lignin-IL interactions were not found to vary significantly, consistent with literature. The combined experimental and simulation studies identify [AMIM]Formate as an efficient biomass solvent and explain its efficacy, suggesting a new approach to rationally select ionic liquid solvents for lignocellulosic deconstruction.
[Mh] Termos MeSH primário: Compostos Alílicos/química
Imidazóis/química
Líquidos Iônicos/química
Polissacarídeos/química
[Mh] Termos MeSH secundário: Ânions/química
Biomassa
Cátions/química
Simulação de Dinâmica Molecular
Solubilidade
Temperatura Ambiente
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1-allyl-3-methylimidazolium); 0 (Allyl Compounds); 0 (Anions); 0 (Cations); 0 (Imidazoles); 0 (Ionic Liquids); 0 (Polysaccharides); 8024-50-8 (hemicellulose); TVE1D62MAK (1-ethyl-3-methylimidazolium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07195g


  2 / 3096 MEDLINE  
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[PMID]:28748237
[Au] Autor:Suzuki J; Miyano N; Yashiro S; Umezawa T; Matsuda F
[Ad] Endereço:Graduate School of Environmental Science, Hokkaido University, N10 W5, Sapporo 060-0810, Japan. umezawa@ees.hokudai.ac.jp fmatsuda@ees.hokudai.ac.jp.
[Ti] Título:Total synthesis of (-)-kainic acid and (+)-allo-kainic acid through SmI -mediated intramolecular coupling between allyl chloride and an α,ß-unsaturated ester.
[So] Source:Org Biomol Chem;15(31):6557-6566, 2017 Aug 09.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A 3,4-disubstituted pyrrolidine ring was effectively cyclized through SmI -mediated reductive coupling between allyl chloride and an α,ß-unsaturated ester, although little has been reported about SmI -promoted C-C bond formation of an allyl chloride with an α,ß-unsaturated ester. Selection of either the 3,4-cis- or 3,4-trans-selective cyclization can be accomplished simply by changing the additives from NiI to HMPA during reductive cyclization conducted in H O-THF. Total synthesis of (-)-kainic acid and (+)-allo-kainic acid, which are pyrrolidine alkaloids used in neuroscience and neuropharmacology as useful molecular probes, was successfully achieved by using the stereo-complementary ring closure reactions promoted by SmI for the construction of the 2,3,4-trisubsituted pyrrolidine scaffold of kainoids.
[Mh] Termos MeSH primário: Compostos Alílicos/química
Iodetos/química
Ácido Caínico/análogos & derivados
Ácido Caínico/síntese química
Samário/química
[Mh] Termos MeSH secundário: Compostos Alílicos/síntese química
Ciclização
Ésteres/síntese química
Ésteres/química
Iodetos/síntese química
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allyl Compounds); 0 (Esters); 0 (Iodides); 0 (samarium diiodide); 42OD65L39F (Samarium); SIV03811UC (Kainic Acid); V2RFT0R50S (allyl chloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1039/c7ob01427a


  3 / 3096 MEDLINE  
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[PMID]:28471522
[Au] Autor:Chen SY; Li Q; Liu XG; Wu JQ; Zhang SS; Wang H
[Ad] Endereço:School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
[Ti] Título:Polycyclization Enabled by Relay Catalysis: One-Pot Manganese-Catalyzed C-H Allylation and Silver-Catalyzed Povarov Reaction.
[So] Source:ChemSusChem;10(11):2360-2364, 2017 06 09.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this study, a Mn /Ag -based relay catalysis process is described for the one-pot synthesis of polycyclic products by a formal [3+2] and [4+2] cycloaddition reaction cascade. A manganese(I) complex catalyzed the first example of directed C-H allylation with allenes, setting the stage for an in situ Povarov cyclization catalyzed by silver(I). The reaction proceeds with high bond-forming efficiency (three C-C bonds), broad substrate scope, high regio- and stereoselectivity, and 100 % atom economy.
[Mh] Termos MeSH primário: Compostos Alílicos/química
Reação de Cicloadição/métodos
Manganês/química
Prata/química
[Mh] Termos MeSH secundário: Catálise
Ciclização
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Allyl Compounds); 3M4G523W1G (Silver); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700452


  4 / 3096 MEDLINE  
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[PMID]:28741790
[Au] Autor:Wang HC; Chu YL; Hsieh SC; Sheen LY
[Ad] Endereço:Department of Cosmetics Applications and Management, Cardinal Tien Junior College of Healthcare and Management, No. 112, Minzu Road, Sindian District, New Taipei, Taiwan.
[Ti] Título:Diallyl trisulfide inhibits cell migration and invasion of human melanoma a375 cells via inhibiting integrin/facal adhesion kinase pathway.
[So] Source:Environ Toxicol;32(11):2352-2359, 2017 Nov.
[Is] ISSN:1522-7278
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Melanoma is the leading cause of death from skin disease due to its propensity for metastasis. Studies have shown that integrin-mediated focal adhesion kinase (FAK) signal pathway is implicated in cell proliferation, survival and metastasis of tumor cells. Our previous results indicated that diallyl trisulfide (DATS) provided its antimelanoma activity via inducing cell cycle arrest and apoptosis. The aim of this study was to explore DATS mediated antimetastatic effect and the corresponding mechanism in human melanoma A375 cells. We found that DATS exhibited an inhibitory effect on the abilities of migration and invasion in A375 cells under noncytotoxic concentrations analyzed by wound healing assays and Matrigel invasion chamber system. DATS attenuated invasion of A375 cells with characteristic of decreased activities and protein expressions of matrix metalloproteinase-2 (MMP-2) and MMP-9. Moreover, DATS exerted an inhibitory effect on cell adhesion of A375 cells, which is in correlation with the change in integrin signaling pathway. Results of Western blotting showed that DATS decreased the levels of several integrin subunits, including α4, α5, αv, ß1, ß3 and ß4. Subsequently, DATS induced a strong decrease in total FAK, phosphorylated FAK Tyr-397,-576, -577, and disorganized F-actin stress fibers, resulting in a nonmigratory phenotype. These results suggest that the antimetastatic potential of DATS for human melanoma cells might be due to the disruption of integrin/FAK signaling pathway.
[Mh] Termos MeSH primário: Compostos Alílicos/farmacologia
Antineoplásicos/farmacologia
Proteína-Tirosina Quinases de Adesão Focal/metabolismo
Integrinas/metabolismo
Melanoma/tratamento farmacológico
Neoplasias Cutâneas/tratamento farmacológico
Sulfetos/farmacologia
[Mh] Termos MeSH secundário: Adesão Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Seres Humanos
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Fosforilação
Transdução de Sinais
Fibras de Estresse/efeitos dos fármacos
Fibras de Estresse/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allyl Compounds); 0 (Antineoplastic Agents); 0 (Integrins); 0 (Sulfides); 0ZO1U5A3XX (diallyl trisulfide); EC 2.7.10.2 (Focal Adhesion Protein-Tyrosine Kinases); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1002/tox.22445


  5 / 3096 MEDLINE  
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[PMID]:27777209
[Au] Autor:Chai JX; Li HH; Wang YY; Chai Q; He WX; Zhou YM; Hu XD; Wang ZH
[Ad] Endereço:1Department of Histology and Embryology, Bengbu Medical College, Bengbu 233030, China; 4Anhui Key Laboratory of Tissue Transplantation, Bengbu 233030, China. E-mail: chaichai123456@163.com.
[Ti] Título:[Effect of diallyl disulfide on learning and memory abilities and hippocampal synapses in mouse models of Alzheimer's disease].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1417-1422, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To explore the effect of diallyl disulfide (DADS) on hippocampal synapses and learning and memory abilities in a mouse model of A1zheimer's disease (AD). METHODS: Mouse models of AD established by agglutinated Aß1-42 injection in the lateral cerebral ventricle were randomized into 4 groups and treated with DADS at the daily doses of 0, 10, 50 and 100 mg/kg by gavage for 30 consecutive days. The learning and memory abilities of the mice were assessed with Morris water maze test; the structures of the dendritic spines and synapses in CA1 region of the hippocampus were observed under transmission electron microscope with silver staining; PSD95 and SYP protein and mRNA expressions in the hippocampus were detected with Western blotting and RT-PCR. RESULTS: Compared with the AD model mice, the mice treated with 50 and 100 mg/kg DADS showed enhanced learning and memory abilities in Morris water maze test. The dendritic spines and synapses in CA1 region of the hippocampus increased obviously and hippocampal expressions of PSD95 and SYP were enhanced in mice treated with 50 and 100 mg/kg DADS. CONCLUSION: DADS at the daily doses of 50 and 100 mg/kg can improve the learning and memory abilities and increase the number of dendritic spines and synapses in the hippocampus in mouse models of AD.
[Mh] Termos MeSH primário: Compostos Alílicos/farmacologia
Doença de Alzheimer/tratamento farmacológico
Dissulfetos/farmacologia
Aprendizagem
Memória
[Mh] Termos MeSH secundário: Animais
Região CA1 Hipocampal/efeitos dos fármacos
Modelos Animais de Doenças
Masculino
Camundongos
Sinapses/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allyl Compounds); 0 (Disulfides); 5HI47O6OA7 (diallyl disulfide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  6 / 3096 MEDLINE  
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[PMID]:28717004
[Au] Autor:Ewing TA; Nguyen QT; Allan RC; Gygli G; Romero E; Binda C; Fraaije MW; Mattevi A; van Berkel WJH
[Ad] Endereço:From the Laboratory of Biochemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.
[Ti] Título:Two tyrosine residues, Tyr-108 and Tyr-503, are responsible for the deprotonation of phenolic substrates in vanillyl-alcohol oxidase.
[So] Source:J Biol Chem;292(35):14668-14679, 2017 Sep 01.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A number of oxidoreductases from the VAO/ -cresol methylhydroxylase flavoprotein family catalyze the oxidation of -substituted phenols. One of the best-studied is vanillyl-alcohol oxidase (VAO) from the fungus For oxidation of phenols by VAO to occur, they must first be bound in the active site of the enzyme in their phenolate anion form. The crystal structure of VAO reveals that two tyrosine residues, Tyr-108 and Tyr-503, are positioned to facilitate this deprotonation. To investigate their role in catalysis, we created three VAO variants, Y108F, Y503F, and Y108F/Y503F, and studied their biochemical properties. Steady-state kinetics indicated that the presence of at least one of the tyrosine residues is essential for efficient catalysis by VAO. Stopped-flow kinetics revealed that the reduction of VAO by chavicol or vanillyl alcohol occurs at two different rates: , which corresponds to its reaction with the deprotonated form of the substrate, and , which corresponds to its reaction with the protonated form of the substrate. In Y108F, Y503F, and Y108F/Y503F, the relative contribution of to the reduction is larger than in wild-type VAO, suggesting deprotonation is impaired in these variants. Binding studies disclosed that the competitive inhibitor isoeugenol is predominantly in its deprotonated form when bound to wild-type VAO, but predominantly in its protonated form when bound to the variants. These results indicate that Tyr-108 and Tyr-503 are responsible for the activation of substrates in VAO, providing new insights into the catalytic mechanism of VAO and related enzymes that oxidize -substituted phenols.
[Mh] Termos MeSH primário: Oxirredutases do Álcool/metabolismo
Proteínas Fúngicas/metabolismo
Modelos Moleculares
Penicillium/enzimologia
Fenóis/metabolismo
Tirosina/química
[Mh] Termos MeSH secundário: Oxirredutases do Álcool/antagonistas & inibidores
Oxirredutases do Álcool/química
Oxirredutases do Álcool/genética
Compostos Alílicos/química
Compostos Alílicos/metabolismo
Substituição de Aminoácidos
Álcoois Benzílicos/química
Álcoois Benzílicos/metabolismo
Ligação Competitiva
Biocatálise/efeitos dos fármacos
Domínio Catalítico
Cristalografia por Raios X
Inibidores Enzimáticos/química
Inibidores Enzimáticos/metabolismo
Inibidores Enzimáticos/farmacologia
Estabilidade Enzimática
Eugenol/análogos & derivados
Eugenol/química
Eugenol/metabolismo
Eugenol/farmacologia
Proteínas Fúngicas/antagonistas & inibidores
Proteínas Fúngicas/química
Proteínas Fúngicas/genética
Mutagênese Sítio-Dirigida
Oxirredução
Fenóis/química
Conformação Proteica
Desdobramento de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-allylphenol); 0 (Allyl Compounds); 0 (Benzyl Alcohols); 0 (Enzyme Inhibitors); 0 (Fungal Proteins); 0 (Phenols); 3T8H1794QW (Eugenol); 42HK56048U (Tyrosine); 5M0MWY797U (isoeugenol); EC 1.1.- (Alcohol Oxidoreductases); EC 1.1.3.38 (vanillyl-alcohol oxidase); X7EA1JUA6M (vanillyl alcohol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M117.778449


  7 / 3096 MEDLINE  
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[PMID]:28574600
[Au] Autor:Wei Z; Shan Y; Tao L; Liu Y; Zhu Z; Liu Z; Wu Y; Chen W; Wang A; Lu Y
[Ad] Endereço:School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
[Ti] Título:Diallyl trisulfides, a natural histone deacetylase inhibitor, attenuate HIF-1α synthesis, and decreases breast cancer metastasis.
[So] Source:Mol Carcinog;56(10):2317-2331, 2017 Oct.
[Is] ISSN:1098-2744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intratumoral hypoxia promotes the distant metastasis of cancer subclones. The clinical expression level of hypoxia-inducible factor-1α (HIF-1α) reflects the prognosis of a variety of cancers, especially breast cancer. Histone deacetylase (HDAC) inhibitors can target HIF-1α protein due to von Hippel-Lindau (VHL) protein-dependent degradation. Dietary organosulfur compounds, such as those in garlic, have been reported as HDAC inhibitors. The effects of diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) on the ratio of firefly/Renilla luciferase activity in hypoxic MDA-MB-231 cells were determined. The mRNA expressions of HIF-1α target genes ANGPTL4, LOXL4, and LOX in hypoxic MDA-MB-231 cells were significantly down-regulated by DATS. DATS attenuated the metastatic potential of MDA-MB-231 cells in hypoxia-induced embryonic zebrafish, xenograft, and orthotopic tumors. Endothelial cell-cancer cell adhesion, wound healing, transwell, and tube formation assays showed that DATS dose-dependently inhibited the migration and angiogenesis of MDA-MB-231 cells in vitro. The expressions of L1CAM, VEGF-A, and EMT-related proteins (Slug, Snail, MMP-2) were inhibited by DATS. DATS dose-dependently inhibited HIF-1α transcriptional activity and hypoxia-induced hematogenous metastasis of MDA-MB-231 cells. It reduced the protein expression of HIF-1α, which did not involve inhibition of HIF-1α mRNA expression or ubiquitin proteasome degradation. Efficient inhibition of HIF-1α expression was required for DATS to resist breast cancer.
[Mh] Termos MeSH primário: Compostos Alílicos/administração & dosagem
Neoplasias da Mama/tratamento farmacológico
Dissulfetos/administração & dosagem
Inibidores de Histona Desacetilases/administração & dosagem
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
Sulfetos/administração & dosagem
[Mh] Termos MeSH secundário: Compostos Alílicos/farmacologia
Animais
Neoplasias da Mama/genética
Neoplasias da Mama/metabolismo
Adesão Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Dissulfetos/farmacologia
Feminino
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Redes Reguladoras de Genes/efeitos dos fármacos
Inibidores de Histona Desacetilases/farmacologia
Seres Humanos
Camundongos
Metástase Neoplásica
Sulfetos/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allyl Compounds); 0 (Disulfides); 0 (HIF1A protein, human); 0 (Histone Deacetylase Inhibitors); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (Sulfides); 0ZO1U5A3XX (diallyl trisulfide); 5HI47O6OA7 (diallyl disulfide); 60G7CF7CWZ (allyl sulfide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1002/mc.22686


  8 / 3096 MEDLINE  
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[PMID]:28571773
[Au] Autor:Hwang JS; Lee YY; Lee DH; Kwon KH
[Ad] Endereço:Division of Cosmetic Arts, Department of Culture Service, Graduate School of Culture and Arts, Dongguk University, Republic of Korea.
[Ti] Título:DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS.
[So] Source:Food Chem Toxicol;106(Pt A):514-521, 2017 Aug.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is a promising anticancer reagent for antitumor therapy. However, many cancer cells, including malignant glioma cells, tend to be resistant to TRAIL, due to repeat treat to cancer cells, highlighting the need for strategies to overcome TRAIL resistance. Here we present that in combination with diallyl trisulfide (DATS), exposure to TRAIL induced apoptosis in TRAIL-resistant glioma cells. Surprisingly, we found that subtoxic concentrations of DATS significantly potentiated TRAIL-induced cytotoxicity and apoptosis in glioma cells. DATS dramatically upregulated DR5 receptor expression but had no effects on DR4 receptor. In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.
[Mh] Termos MeSH primário: Compostos Alílicos/farmacologia
Apoptose/efeitos dos fármacos
Glioma/genética
Espécies Reativas de Oxigênio/metabolismo
Receptores do Ligante Indutor de Apoptose Relacionado a TNF/metabolismo
Sulfetos/farmacologia
Ligante Indutor de Apoptose Relacionado a TNF/metabolismo
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Glioma/tratamento farmacológico
Glioma/metabolismo
Glioma/fisiopatologia
Seres Humanos
Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética
Ligante Indutor de Apoptose Relacionado a TNF/genética
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allyl Compounds); 0 (Reactive Oxygen Species); 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand); 0 (Sulfides); 0 (TNF-Related Apoptosis-Inducing Ligand); 0 (Tumor Necrosis Factor-alpha); 0ZO1U5A3XX (diallyl trisulfide)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


  9 / 3096 MEDLINE  
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[PMID]:28476961
[Au] Autor:Sana SS; Boya VKN
[Ad] Endereço:Department of Materials Science and Nanotechnology, Yogi Vemana University, Kadapa 516 003, Andhra Pradesh, India.
[Ti] Título:Poly (vinyl alcohol)/poly (acrylamide- -diallyldimethyl ammonium chloride) semi-IPN hydrogels for ciprofloxacin hydrochloride drug delivery.
[So] Source:IET Nanobiotechnol;11(1):52-56, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herein, the authors developed a new and potential semi-interpenetrating polymer network (semi-IPN) hydrogels of poly vinyl alcohol (PVA), acryl amide and diallyldimethyl ammonium chloride employing chemical cross-linker N, N'-methylene bisacrylamide (NNMBA) and ammonium persulphate as an initiator by radical polymerisation. To analyse the copolymer formation between two monomers and IPN cross-linking reaction, the resulting hydrogel was characterised by Fourier transform infrared spectroscopy and the surface morphology was analysed using scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction studies were also carried out for investigating drug loading and distribution and swelling experiments were carried out for the uptake of water. In vitro release of ciprofloxacin hydrochloride from hydrogel was performed at intestinal conditions. The amount of PVA, NNMBA and total monomer concentration was found to strongly control the drug release behaviour from the hydrogels.
[Mh] Termos MeSH primário: Resinas Acrílicas/química
Compostos Alílicos/química
Ciprofloxacino/química
Preparações de Ação Retardada/química
Hidrogéis/síntese química
Nanocápsulas/química
Nanocápsulas/ultraestrutura
Álcool de Polivinil/química
Compostos de Amônio Quaternário/química
[Mh] Termos MeSH secundário: Absorção Fisico-Química
Antibacterianos/administração & dosagem
Antibacterianos/química
Ciprofloxacino/administração & dosagem
Reagentes para Ligações Cruzadas/química
Preparações de Ação Retardada/administração & dosagem
Difusão
Nanocápsulas/administração & dosagem
Tamanho da Partícula
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Allyl Compounds); 0 (Anti-Bacterial Agents); 0 (Cross-Linking Reagents); 0 (Delayed-Action Preparations); 0 (Hydrogels); 0 (Nanocapsules); 0 (Quaternary Ammonium Compounds); 0 (poly(acrylamide-co-diallyldimethylammonium chloride)); 5E8K9I0O4U (Ciprofloxacin); 9002-89-5 (Polyvinyl Alcohol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0079


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[PMID]:28425643
[Au] Autor:Völker T; Meggers E
[Ad] Endereço:Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, 35043, Marburg, Germany.
[Ti] Título:Chemical Activation in Blood Serum and Human Cell Culture: Improved Ruthenium Complex for Catalytic Uncaging of Alloc-Protected Amines.
[So] Source:Chembiochem;18(12):1083-1086, 2017 Jun 19.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Chemical (as opposed to light-induced) activation of caged molecules is a rapidly advancing approach to trigger biological processes. We previously introduced the ruthenium-catalyzed release of allyloxycarbonyl (alloc)-protected amines in human cells. A restriction of this and all other methods is the limited lifetime of the catalyst, thus hampering meaningful applications. In this study, we addressed this problem with the development of a new generation of ruthenium complexes for the uncaging of alloc-protected amines with superior catalytic activity. Under biologically relevant conditions, we achieved a turnover number >300, a reaction rate of 580 m s , and we observed high activity in blood serum. Furthermore, alloc-protected doxorubicin, as an anticancer prodrug, could be activated in human cell culture and induced apoptosis with a single low dose (1 µm) of the new catalyst.
[Mh] Termos MeSH primário: Compostos Alílicos/química
Aminas/química
Complexos de Coordenação/síntese química
Doxorrubicina/agonistas
Rutênio/química
[Mh] Termos MeSH secundário: Antibióticos Antineoplásicos/sangue
Antibióticos Antineoplásicos/síntese química
Antibióticos Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Catálise
Complexos de Coordenação/sangue
Complexos de Coordenação/química
Doxorrubicina/análogos & derivados
Doxorrubicina/sangue
Doxorrubicina/farmacologia
Células HeLa
Seres Humanos
Concentração Inibidora 50
Pró-Fármacos/síntese química
Pró-Fármacos/farmacologia
Rutênio/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allyl Compounds); 0 (Amines); 0 (Antibiotics, Antineoplastic); 0 (Coordination Complexes); 0 (Prodrugs); 7UI0TKC3U5 (Ruthenium); 80168379AG (Doxorubicin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700168



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