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[PMID]:29489681
[Au] Autor:Kim CO; Song J; Min JY; Park SJ; Lee HM; Byon HJ
[Ad] Endereço:Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University Health System, Seodaemun-gu, Seoul.
[Ti] Título:A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set: A preliminary study.
[So] Source:Medicine (Baltimore);97(9):e9829, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a risk of drug sorption into an intravenous administration set composed of polyvinyl chloride (PVC), polyurethane (PU), or polyolefin (PO). This has implications on the dose of the active ingredient the patient receives, and thus therapeutic success. This study aimed to determine the plasma concentration of nitroglycerin and the effect of nitroglycerin on patients based on the composition of the administration set. METHODS: Using a randomized, open-labeled, 3 × 3 crossover method, 9 volunteers were assigned to 3 groups. In period I, nitroglycerin (100 µg/mL) was infused via a PVC- (group A), PU- (group B), or PO-based (group C) administration set. In period II, PU- (group A), PO- (group B), and PVC-based (group C) administration sets were used, and in period III, PO- (group A), PVC- (group B), and PU-based (group C) administration sets were used. The rate of drug administration in all periods was 12 mL/hour for 30 minutes using an infusion pump. Blood samples were collected, and the plasma concentrations of nitroglycerin were analyzed using validated high-performance liquid chromatography coupled with tandem mass spectrometry. Blood pressure was determined using a sphygmomanometer applied to the other upper arm at an interval of 5 minutes. RESULTS: We observed that the mean plasma concentration of nitroglycerin over time when administered using a PO-based tube was higher than that when using a PU- or PVC-based tube. When the percent change of the mean arterial pressure from baseline at each time point was compared among groups, there were statistically significant differences between PU and PO or PVC at most points during nitroglycerin infusion. CONCLUSION: Our results showed higher nitroglycerin plasma concentration and lower arterial pressure when a PO-based administration set was used than when a PVC- or PU-based administration set was used. PO-based administration sets may be more appropriate for nitroglycerin administration compared to those composed of PVC or PU.
[Mh] Termos MeSH primário: Administração Intravenosa/instrumentação
Desenho de Equipamento
Bombas de Infusão
Nitroglicerina/farmacocinética
Vasodilatadores/farmacocinética
[Mh] Termos MeSH secundário: Administração Intravenosa/métodos
Adulto
Pressão Sanguínea
Cromatografia Líquida/métodos
Estudos Cross-Over
Seres Humanos
Masculino
Meia-Idade
Nitroglicerina/administração & dosagem
Nitroglicerina/sangue
Polienos
Poliuretanos
Cloreto de Polivinila
Espectrometria de Massas em Tandem
Vasodilatadores/administração & dosagem
Vasodilatadores/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Polyenes); 0 (Polyurethanes); 0 (Vasodilator Agents); 83136-87-2 (PL 732); 9002-86-2 (Polyvinyl Chloride); G59M7S0WS3 (Nitroglycerin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009829


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[PMID]:28450394
[Au] Autor:Korge P; John SA; Calmettes G; Weiss JN
[Ad] Endereço:From the UCLA Cardiovascular Research Laboratory and the Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095.
[Ti] Título:Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II.
[So] Source:J Biol Chem;292(24):9896-9905, 2017 06 16.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Succinate-driven reverse electron transport (RET) through complex I is hypothesized to be a major source of reactive oxygen species (ROS) that induces permeability transition pore (PTP) opening and damages the heart during ischemia/reperfusion. Because RET can only generate ROS when mitochondria are fully polarized, this mechanism is self-limiting once PTP opens during reperfusion. In the accompanying article (Korge, P., Calmettes, G., John, S. A., and Weiss, J. N. (2017) 292, 9882-9895), we showed that ROS production after PTP opening can be sustained when complex III is damaged (simulated by antimycin). Here we show that complex II can also contribute to sustained ROS production in isolated rabbit cardiac mitochondria following inner membrane pore formation induced by either alamethicin or calcium-induced PTP opening. Two conditions are required to maximize malonate-sensitive ROS production by complex II in isolated mitochondria: ( ) complex II inhibition by atpenin A5 or complex III inhibition by stigmatellin that results in succinate-dependent reduction of the dicarboxylate-binding site of complex II (site II ); ( ) pore opening in the inner membrane resulting in rapid efflux of succinate/fumarate and other dicarboxylates capable of competitively binding to site II The decrease in matrix [dicarboxylate] allows O access to reduced site II , thereby making electron donation to O possible, explaining the rapid increase in ROS production provided that site II is reduced. Because ischemia is known to inhibit complexes II and III and increase matrix succinate/fumarate levels, we hypothesize that by allowing dicarboxylate efflux from the matrix, PTP opening during reperfusion may activate sustained ROS production by this mechanism after RET-driven ROS production has ceased.
[Mh] Termos MeSH primário: Complexo II de Transporte de Elétrons/metabolismo
Mitocôndrias Cardíacas/metabolismo
Modelos Moleculares
Espécies Reativas de Oxigênio/agonistas
[Mh] Termos MeSH secundário: Alameticina/farmacologia
Animais
Sítios de Ligação
Ligação Competitiva
Biocatálise/efeitos dos fármacos
Sinalização do Cálcio/efeitos dos fármacos
Transporte de Elétrons/efeitos dos fármacos
Complexo II de Transporte de Elétrons/antagonistas & inibidores
Complexo II de Transporte de Elétrons/química
Inibidores Enzimáticos/farmacologia
Fumaratos/metabolismo
Ionóforos/farmacologia
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias Cardíacas/química
Mitocôndrias Cardíacas/efeitos dos fármacos
Oxirredução
Permeabilidade/efeitos dos fármacos
Polienos/farmacologia
Porosidade
Piridonas/farmacologia
Coelhos
Espécies Reativas de Oxigênio/metabolismo
Ácido Succínico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Fumarates); 0 (Ionophores); 0 (Polyenes); 0 (Pyridones); 0 (Reactive Oxygen Species); 119509-24-9 (atpenin A5); 27061-78-5 (Alamethicin); 91682-96-1 (stigmatellin); AB6MNQ6J6L (Succinic Acid); EC 1.3.5.1 (Electron Transport Complex II)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.768325


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[PMID]:28450391
[Au] Autor:Korge P; Calmettes G; John SA; Weiss JN
[Ad] Endereço:From the UCLA Cardiovascular Research Laboratory and the Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095.
[Ti] Título:Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex III.
[So] Source:J Biol Chem;292(24):9882-9895, 2017 06 16.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent evidence has implicated succinate-driven reverse electron transport (RET) through complex I as a major source of damaging reactive oxygen species (ROS) underlying reperfusion injury after prolonged cardiac ischemia. However, this explanation may be incomplete, because RET on reperfusion is self-limiting and therefore transient. RET can only generate ROS when mitochondria are well polarized, and it ceases when permeability transition pores (PTP) open during reperfusion. Because prolonged ischemia/reperfusion also damages electron transport complexes, we investigated whether such damage could lead to ROS production after PTP opening has occurred. Using isolated cardiac mitochondria, we demonstrate a novel mechanism by which antimycin-inhibited complex III generates significant amounts of ROS in the presence of Mg and NAD and the absence of exogenous substrates upon inner membrane pore formation by alamethicin or Ca -induced PTP opening. We show that H O production under these conditions is related to Mg -dependent NADH generation by malic enzyme. H O production is blocked by stigmatellin, indicating its origin from complex III, and by piericidin, demonstrating the importance of NADH-related ubiquinone reduction for ROS production under these conditions. For maximal ROS production, the rate of NADH generation has to be equal or below that of NADH oxidation, as further increases in [NADH] elevate ubiquinol-related complex III reduction beyond the optimal range for ROS generation. These results suggest that if complex III is damaged during ischemia, PTP opening may result in succinate/malate-fueled ROS production from complex III due to activation of malic enzyme by increases in matrix [Mg ], [NAD ], and [ADP].
[Mh] Termos MeSH primário: Complexo III da Cadeia de Transporte de Elétrons/metabolismo
Malato Desidrogenase/metabolismo
Mitocôndrias Cardíacas/metabolismo
Espécies Reativas de Oxigênio/agonistas
[Mh] Termos MeSH secundário: Difosfato de Adenosina/metabolismo
Alameticina/farmacologia
Animais
Antimicina A/análogos & derivados
Antimicina A/farmacologia
Biocatálise/efeitos dos fármacos
Sinalização do Cálcio/efeitos dos fármacos
Complexo III da Cadeia de Transporte de Elétrons/antagonistas & inibidores
Ativação Enzimática/efeitos dos fármacos
Inibidores Enzimáticos/farmacologia
Peróxido de Hidrogênio/metabolismo
Ionóforos/farmacologia
Magnésio/metabolismo
Malato Desidrogenase/química
Mitocôndrias Cardíacas/química
Mitocôndrias Cardíacas/efeitos dos fármacos
NAD/metabolismo
Oxirredução
Polienos/farmacologia
Porosidade/efeitos dos fármacos
Piridinas/farmacologia
Coelhos
Espécies Reativas de Oxigênio/metabolismo
Ubiquinona/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Ionophores); 0 (Polyenes); 0 (Pyridines); 0 (Reactive Oxygen Species); 0U46U6E8UK (NAD); 11118-72-2 (antimycin); 1339-63-5 (Ubiquinone); 27061-78-5 (Alamethicin); 61D2G4IYVH (Adenosine Diphosphate); 642-15-9 (Antimycin A); 8VT513UJ9R (piericidin A); 91682-96-1 (stigmatellin); BBX060AN9V (Hydrogen Peroxide); EC 1.1.1.37 (Malate Dehydrogenase); EC 1.10.2.2 (Electron Transport Complex III); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.768317


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[PMID]:28985565
[Au] Autor:Cooke TF; Fischer CR; Wu P; Jiang TX; Xie KT; Kuo J; Doctorov E; Zehnder A; Khosla C; Chuong CM; Bustamante CD
[Ad] Endereço:Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
[Ti] Título:Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars.
[So] Source:Cell;171(2):427-439.e21, 2017 Oct 05.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parrot feathers contain red, orange, and yellow polyene pigments called psittacofulvins. Budgerigars are parrots that have been extensively bred for plumage traits during the last century, but the underlying genes are unknown. Here we use genome-wide association mapping and gene-expression analysis to map the Mendelian blue locus, which abolishes yellow pigmentation in the budgerigar. We find that the blue trait maps to a single amino acid substitution (R644W) in an uncharacterized polyketide synthase (MuPKS). When we expressed MuPKS heterologously in yeast, yellow pigments accumulated. Mass spectrometry confirmed that these yellow pigments match those found in feathers. The R644W substitution abolished MuPKS activity. Furthermore, gene-expression data from feathers of different bird species suggest that parrots acquired their colors through regulatory changes that drive high expression of MuPKS in feather epithelia. Our data also help formulate biochemical models that may explain natural color variation in parrots. VIDEO ABSTRACT.
[Mh] Termos MeSH primário: Proteínas Aviárias/genética
Plumas/fisiologia
Melopsittacus/genética
Pigmentos Biológicos/biossíntese
Polienos/metabolismo
Policetídeo Sintases/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Proteínas Aviárias/metabolismo
Plumas/anatomia & histologia
Plumas/química
Expressão Gênica
Genoma
Estudo de Associação Genômica Ampla
Melopsittacus/anatomia & histologia
Melopsittacus/fisiologia
Pigmentação
Policetídeo Sintases/metabolismo
Polimorfismo de Nucleotídeo Único
Regeneração
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Avian Proteins); 0 (Pigments, Biological); 0 (Polyenes); 79956-01-7 (Polyketide Synthases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171007
[St] Status:MEDLINE


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[PMID]:28858135
[Au] Autor:Fang BX; Wang LH; Liu HM; Chen FC; Liu J
[Ad] Endereço:aDepartment of Pharmacy, Dongfeng Hospital bDepartment of Pharmacy, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China.
[Ti] Título:Stability study of dezocine in 0.9% sodium chloride solutions for patient-controlled analgesia administration.
[So] Source:Medicine (Baltimore);96(35):e7979, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dezocine, a mixed agonist/antagonist of opioid receptors, has been used in iv patient-controlled analgesia (PCA) pumps for postoperative pain control. The aim of this study was to investigate the physicochemical stability of dezocine solutions in 0.9% sodium chloride for injection for PCA administration. METHODS: Solutions of dezocine (0.3, 0.45, or 0.6 mg/mL in 0.9% sodium chloride for injection) were stored in polyolefin bags and glass bottles. Their stabilities at storage conditions of 4°C for 14 days and 25°C for 72 hours were studied. For all preparations, physical characteristics (including pH, color, and presence of precipitates) were evaluated. Each preparation of dezocine was also analyzed using a stability-indicating high-performance liquid chromatography method. A solution was considered stable if it maintained at least 90% of its initial concentration. RESULTS: No notable changes in pH, color, or precipitation were observed in any of the prepared solutions over the testing period. All formulations maintained >97% of the initial dezocine concentration under the storage conditions evaluated. CONCLUSIONS: Dezocine solutions at 0.3, 0.45, or 0.6 mg/mL in 0.9% sodium chloride for PCA administration were stable for 72 hours at 25°C and for 14 days at 4°C when packaged in polyolefin bags or glass bottles and protected from light.
[Mh] Termos MeSH primário: Analgesia Controlada pelo Paciente
Analgésicos Opioides/química
Compostos Bicíclicos Heterocíclicos com Pontes/química
Estabilidade de Medicamentos
Tetra-Hidronaftalenos/química
[Mh] Termos MeSH secundário: Analgésicos Opioides/administração & dosagem
Compostos Bicíclicos Heterocíclicos com Pontes/administração & dosagem
Cromatografia Líquida de Alta Pressão
Armazenamento de Medicamentos/métodos
Seres Humanos
Concentração de Íons de Hidrogênio
Plásticos
Polienos
Solução Salina Hipertônica
Tetra-Hidronaftalenos/administração & dosagem
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Plastics); 0 (Polyenes); 0 (Saline Solution, Hypertonic); 0 (Tetrahydronaphthalenes); 83136-87-2 (PL 732); VHX8K5SV4X (dezocine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007979


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[PMID]:28845982
[Au] Autor:Park HB; Park JS; Lee SI; Shin B; Oh DC; Kwon HC
[Ad] Endereço:Natural Constituents Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 25451, Republic of Korea.
[Ti] Título:Gordonic Acid, a Polyketide Glycoside Derived from Bacterial Coculture of Streptomyces and Gordonia Species.
[So] Source:J Nat Prod;80(9):2542-2546, 2017 Sep 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite numerous efforts to discover novel bioactive products from microorganisms, previously reported compounds are repetitively reisolated. A new polyketide glycoside, gordonic acid (1), isolated from the mixed culture of two Gram-positive bacteria, Gordonia sp. KMC005 and Streptomyces tendae KMC006, is reported. The structure of 1 was characterized as an acyclic polyene polyketide substituted with a ß-d-digitoxopyranose through NMR, HR-ESI-QTOF-MS, IR, and UV spectral data. The stereochemistry for 1 was determined by Mosher's method followed by 2D NOESY analysis and by NMR chemical shift calculations supported by DP4 analysis. Gordonic acid (1) showed weak activity against Micrococcus luteus and Enterococcus hirae.
[Mh] Termos MeSH primário: Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Gordonia (Bactéria)/química
Bactérias Gram-Positivas/efeitos dos fármacos
Micrococcus luteus/química
Polienos/química
Policetídeos/química
Policetídeos/isolamento & purificação
Policetídeos/farmacologia
Streptomyces/química
[Mh] Termos MeSH secundário: Técnicas de Cocultura
Glicosídeos/química
Espectroscopia de Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Polyenes); 0 (Polyketides); 0 (gordonic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.7b00293


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[PMID]:28844715
[Au] Autor:Datta A; Kim H; Lal M; McGee L; Johnson A; Moustafa AA; Jones JC; Mondal D; Ferrer M; Abdel-Mageed AB
[Ad] Endereço:Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, United States.
[Ti] Título:Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.
[So] Source:Cancer Lett;408:73-81, 2017 Nov 01.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Emerging evidence links exosomes to cancer progression by the trafficking of oncogenic factors and neoplastic reprogramming of stem cells. This necessitates identification and integration of functionally validated exosome-targeting therapeutics into current cancer management regimens. We employed quantitative high throughput screen on two libraries to identify exosome-targeting drugs; a commercially available collection of 1280 pharmacologically active compounds and a collection of 3300 clinically approved compounds. Manumycin-A (MA), a natural microbial metabolite, was identified as an inhibitor of exosome biogenesis and secretion by castration-resistant prostate cancer (CRPC) C4-2B, but not the normal RWPE-1, cells. While no effect was observed on cell growth, MA attenuated ESCRT-0 proteins Hrs, ALIX and Rab27a and exosome biogenesis and secretion by CRPC cells. The MA inhibitory effect is primarily mediated via targeted inhibition of the Ras/Raf/ERK1/2 signaling. The Ras-dependent MA suppression of exosome biogenesis and secretion is partly mediated by ERK-dependent inhibition of the oncogenic splicing factor hnRNP H1. Our findings suggest that MA is a potential drug candidate to suppress exosome biogenesis and secretion by CRPC cells.
[Mh] Termos MeSH primário: Exossomos/metabolismo
Ribonucleoproteínas Nucleares Heterogêneas Grupo F-H/metabolismo
Proteína Quinase 1 Ativada por Mitógeno/metabolismo
Proteína Quinase 3 Ativada por Mitógeno/metabolismo
Polienos/farmacologia
Alcamidas Poli-Insaturadas/farmacologia
Neoplasias de Próstata Resistentes à Castração/tratamento farmacológico
Quinases raf/metabolismo
Proteínas ras/metabolismo
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Inibidores Enzimáticos/farmacologia
Exossomos/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Ribonucleoproteínas Nucleares Heterogêneas Grupo F-H/genética
Seres Humanos
Masculino
Proteína Quinase 1 Ativada por Mitógeno/genética
Proteína Quinase 3 Ativada por Mitógeno/genética
Neoplasias de Próstata Resistentes à Castração/metabolismo
Neoplasias de Próstata Resistentes à Castração/patologia
Transdução de Sinais
Células Tumorais Cultivadas
Quinases raf/genética
Proteínas ras/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Heterogeneous-Nuclear Ribonucleoprotein Group F-H); 0 (Polyenes); 0 (Polyunsaturated Alkamides); EC 2.7.11.1 (raf Kinases); EC 2.7.11.24 (MAPK1 protein, human); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3); EC 3.6.5.2 (ras Proteins); OIQ298X4XD (manumycin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


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[PMID]:28661684
[Au] Autor:Adak S; Begley TP
[Ad] Endereço:Department of Chemistry, Texas A&M University , 3255 TAMU, College Station, Texas 77843, United States.
[Ti] Título:RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide.
[So] Source:Biochemistry;56(29):3708-3709, 2017 Jul 25.
[Is] ISSN:1520-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RutA is a novel flavoenzyme on the uracil catabolic pathway that catalyzes uracil ring opening by a unique amide oxidation reaction. Here we provide evidence that this reaction also involves the formation of a flavin-N5-oxide.
[Mh] Termos MeSH primário: Dinitrocresóis/química
Modelos Químicos
Uracila/química
[Mh] Termos MeSH secundário: Catálise
Polienos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dinitrocresols); 0 (Polyenes); 1604ZJR09T (4,6-dinitro-o-cresol); 56HH86ZVCT (Uracil); 68248-02-2 (flavopentin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170727
[Lr] Data última revisão:
170727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biochem.7b00493


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[PMID]:28554565
[Au] Autor:Jezek J; Engstová H; Jezek P
[Ad] Endereço:Department No. 75, Institute of Physiology, Academy of Sciences, Vídenská 1083, Prague 14220, Czech Republic. Electronic address: jezekj6@rowan.edu.
[Ti] Título:Antioxidant mechanism of mitochondria-targeted plastoquinone SkQ1 is suppressed in aglycemic HepG2 cells dependent on oxidative phosphorylation.
[So] Source:Biochim Biophys Acta;1858(9):750-762, 2017 09.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Previously suggested antioxidant mechanisms for mitochondria-targeted plastoquinone SkQ1 included: i) ion-pairing of cationic SkQ1 with free fatty acid anions resulting in uncoupling; ii) SkQ1H ability to interact with lipoperoxyl radical; iii) interference with electron flow at the inner ubiquinone (Q) binding site of Complex III (Q ), involving the reduction of SkQ1 to SkQ1H by ubiquinol. We elucidated SkQ1 antioxidant properties by confocal fluorescence semi-quantification of mitochondrial superoxide (J ) and cytosolic H O (J ) release rates in HepG2 cells. Only in glycolytic cells, SkQ1 prevented the rotenone-induced enhancement of J and J but not basal releases without rotenone. The effect ceased in glutaminolytic aglycemic cells, in which the redox parameter NAD(P)H/FAD increased after rotenone in contrast to its decrease in glycolytic cells. Autofluorescence decay indicated decreased NADPH/NADH ratios with rotenone in both metabolic modes. SkQ1 did not increase cell respiration and diminished J established high by antimycin or myxothiazol but not by stigmatellin. The revealed SkQ1 antioxidant modes reflect its reduction to SkQ1H at Complex I I or Complex III Q site. Both reductions diminish electron diversions to oxygen thus attenuating superoxide formation. Resulting SkQ1H oxidizes back to SkQ1at the second (flavin) Complex I site, previously indicated for MitoQ . Regeneration proceeds only at lower NAD(P)H/FAD in glycolytic cells. In contrast, cyclic SkQ1 reduction/SkQ1H oxidation does not substantiate antioxidant activity in intact cells in the absence of oxidative stress (neither pro-oxidant activity, representing a great advantage). A targeted delivery to oxidative-stressed tissues is suggested for the effective antioxidant therapy based on SkQ1.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Mitocôndrias/efeitos dos fármacos
Fosforilação Oxidativa
Plastoquinona/análogos & derivados
[Mh] Termos MeSH secundário: Antimicina A/análogos & derivados
Antimicina A/farmacologia
Complexo I de Transporte de Elétrons/metabolismo
Complexo III da Cadeia de Transporte de Elétrons/metabolismo
Flavina-Adenina Dinucleotídeo/metabolismo
Glicólise
Células Hep G2
Seres Humanos
Metacrilatos/farmacologia
Mitocôndrias/metabolismo
NAD/metabolismo
Oxirredução
Estresse Oxidativo
Plastoquinona/farmacologia
Polienos/farmacologia
Rotenona/farmacologia
Superóxidos/metabolismo
Tiazóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (10-(6'-plastoquinonyl)decyltriphenylphosphonium); 0 (Antioxidants); 0 (Methacrylates); 0 (Polyenes); 0 (Thiazoles); 03L9OT429T (Rotenone); 0U46U6E8UK (NAD); 11062-77-4 (Superoxides); 11118-72-2 (antimycin); 146-14-5 (Flavin-Adenine Dinucleotide); 642-15-9 (Antimycin A); 76706-55-3 (myxothiazol); 91682-96-1 (stigmatellin); EC 1.10.2.2 (Electron Transport Complex III); EC 1.6.5.3 (Electron Transport Complex I); OAC30J69CN (Plastoquinone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28500568
[Au] Autor:Hall DR; Farman D; Domínguez JC; Pajares JA
[Ad] Endereço:Natural Resources Institute, University of Greenwich, Chatham Maritime, Kent, ME4 4TB, UK. d.r.hall@gre.ac.uk.
[Ti] Título:Female Sex Pheromone of the Cone Moth, Dioryctria mendacella: Investigation of Synergism between Type I and Type II Pheromone Components.
[So] Source:J Chem Ecol;43(5):433-442, 2017 May.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Polyunsaturated hydrocarbons (Type II pheromone components) have been reported to be synergists for unsaturated acetates, alcohols or aldehydes (Type I components) in the sex pheromones of several species of Lepidoptera. However, there is some debate over whether the active components are the hydrocarbons themselves or more volatile degradation products. Extracts of pheromone glands of adult females of the cone moth, Dioryctria mendacella (Lepidoptera: Pyralidae), contain (Z,E)-9,11-tetradecadienyl acetate (ZE9,11-14:Ac) and at least ten times as much (Z,Z,Z,Z,Z)-3,6,9,12,15-pentacosapentaene (ZZZZZ3,6,9,12,15-25:H). The former elicits a strong electroantennogram response from males while no response could be recorded to the latter. In field trapping tests, both compounds were individually unattractive to male D. mendacella moths, but blends of the two compounds containing at least a 10:1 ratio of ZZZZZ3,6,9,12,15-25:H : ZE9,11-14:Ac were highly attractive. The relatively involatile hydrocarbon was shown to be released from the dispensers used and no significant degradation could be detected. Furthermore, blends of ZE9,11-14:Ac and analogs of ZZZZZ3,6,9,12,15-25:H with fewer carbons and/or double bonds that might be expected to produce similar degradation products to ZZZZZ3,6,9,12,15-25:H were unattractive. This indicated a specific response to the hydrocarbon itself, further substantiated by the observation that related hydrocarbons did not interfere with the activity of ZZZZZ3,6,9,12,15-25:H. Thus a three-step conversion of fish oil was used to produce a blend of unsaturated hydrocarbons containing ZZZZZ3,6,9,12,15-25:H as the major component, albeit only 30% of the total, and a blend of this material with ZE9,11-14:Ac was as attractive to male D. mendacella moths as blends with an equivalent amount of the purified material. This mixture of unsaturated hydrocarbons is much cheaper to produce than the pure pentaene, and may be useful in lures for other species using these compounds. Dioryctria mendacella is a major constraint to production of edible pine kernels throughout the Mediterranean region. Pheromone traps will provide a means to improve monitoring of seasonal flight patterns and changes in population abundance of this pest.
[Mh] Termos MeSH primário: Mariposas/metabolismo
Atrativos Sexuais/química
[Mh] Termos MeSH secundário: Animais
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Masculino
Mariposas/química
Polienos/análise
Polienos/síntese química
Polienos/metabolismo
Atrativos Sexuais/análise
Atrativos Sexuais/síntese química
Atrativos Sexuais/metabolismo
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 ((3Z,6Z,9Z, 12Z, 15Z)-pentacosapentaene); 0 ((9Z, 11E)-tetradecadienyl acetate); 0 (Polyenes); 0 (Sex Attractants)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0846-8



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