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  1 / 15737 MEDLINE  
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[PMID]:29367485
[Au] Autor:Umigai N; Murakami K; Shimizu R; Takeda R; Azuma T
[Ad] Endereço:Riken Vitamin Co., Ltd.
[Ti] Título:Safety Evaluation and Plasma Carotenoid Accumulation in Healthy Adult Subjects after 12 Weeks of Paprika Oleoresin Supplementation.
[So] Source:J Oleo Sci;67(2):225-234, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Paprika oleoresin is obtained by solvent extraction from Capsicum annuum L. fruits and contains multiple carotenoids, such as capsanthin, ß-carotene, zeaxanthin, and ß-cryptoxanthin, which are considered protective against various diseases. Herein, we investigated the effect of paprika oleoresin supplementation on plasma carotenoid accumulation and evaluated the safety of the oleoresin. We used a double-blinded, placebo-controlled comparative clinical study design and tested the effects of varying doses in healthy adult subjects. In total, 33 subjects were randomly divided into three groups to take capsules containing 0, 20, or 100 mg of paprika oleoresin daily for 12 consecutive weeks. Plasma carotenoid concentrations were measured at 0, 4, 8, and 12 weeks, and the safety of paprika oleoresin capsules was investigated using analyses of blood biochemistry, hematology, and urine contents. In these experiments, ß-cryptoxanthin and zeaxanthin dose-dependently accumulated in plasma within the dose range of the study over 12 consecutive weeks of paprika oleoresin supplementation. Moreover, ß-cryptoxanthin accumulated to higher levels than the other paprika oleoresin carotenoids. In contrast, capsanthin was not detected in plasma before or during the 12-week treatment period. Finally, no adverse events were associated with intake of paprika oleoresin (20 and 100 mg/day) in safety evaluations. Paprika oleoresin is a suitable source of carotenoids, especially ß-cryptoxanthin.
[Mh] Termos MeSH primário: Capsicum/química
Carotenoides/sangue
Suplementos Nutricionais
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
[Mh] Termos MeSH secundário: beta-Criptoxantina/sangue
Suplementos Nutricionais/efeitos adversos
Relação Dose-Resposta a Droga
Método Duplo-Cego
Extratos Vegetais/efeitos adversos
Distribuição Aleatória
Segurança
Solventes
Fatores de Tempo
Zeaxantinas/sangue
[Pt] Tipo de publicação:CLINICAL STUDY; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Beta-Cryptoxanthin); 0 (Plant Extracts); 0 (Solvents); 0 (Zeaxanthins); 0 (oleoresins); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17155


  2 / 15737 MEDLINE  
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[PMID]:29403051
[Au] Autor:Koch RE; Kavazis AN; Hasselquist D; Hood WR; Zhang Y; Toomey MB; Hill GE
[Ad] Endereço:Department of Biological Sciences, Auburn University, 331 Funchess Hall, Auburn, AL, 36849, USA. rebecca.adrian@monash.edu.
[Ti] Título:No evidence that carotenoid pigments boost either immune or antioxidant defenses in a songbird.
[So] Source:Nat Commun;9(1):491, 2018 02 05.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dietary carotenoids have been proposed to boost immune system and antioxidant functions in vertebrate animals, but studies aimed at testing these physiological functions of carotenoids have often failed to find support. Here we subject yellow canaries (Serinus canaria), which possess high levels of carotenoids in their tissue, and white recessive canaries, which possess a knockdown mutation that results in very low levels of tissue carotenoids, to oxidative and pathogen challenges. Across diverse measures of physiological performance, we detect no differences between carotenoid-rich yellow and carotenoid-deficient white canaries. These results add further challenge to the assumption that carotenoids are directly involved in supporting physiological function in vertebrate animals. While some dietary carotenoids provide indirect benefits as retinoid precursors, our observations suggest that carotenoids themselves may play little to no direct role in key physiological processes in birds.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Canários/imunologia
Carotenoides/metabolismo
Regulação da Expressão Gênica/imunologia
Imunidade Inata/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Canários/genética
Lipopolissacarídeos/metabolismo
Mutação
Pigmentação/genética
Pigmentação/imunologia
Pigmentos Biológicos
Receptores Depuradores Classe B/genética
Receptores Depuradores Classe B/metabolismo
Toxoide Tetânico/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antioxidants); 0 (Lipopolysaccharides); 0 (Pigments, Biological); 0 (Scavenger Receptors, Class B); 0 (Tetanus Toxoid); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-018-02974-x


  3 / 15737 MEDLINE  
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[PMID]:28455259
[Au] Autor:Wengreen HJ; Nix E; Madden GJ
[Ad] Endereço:Utah State University, 8700 Old Main Hill, Logan, UT 84321, United States. Electronic address: heidi.wengreen@usu.edu.
[Ti] Título:The effect of social norms messaging regarding skin carotenoid concentrations among college students.
[So] Source:Appetite;116:39-44, 2017 09 01.
[Is] ISSN:1095-8304
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Descriptive social-normative messaging positively influences short-term dietary choices and healthy food intake. The purpose of this study was to evaluate the effects of descriptive normative messages on college students' skin carotenoid concentrations (a biomarker of carotenoid-containing fruit and vegetable [FV] intake) over an 8-week period. 251 college students consented to participate and 74% completed the study. Students were randomly assigned to groups who, following a baseline evaluation of skin-carotenoid levels, were told how their score ranked within a peer group of college students attending the same university (Individualized Normative group), that their score was in the lower 20th percentile of the peer group (Manipulated Normative group), or were given no information about their score or the peer group (Control group). Skin carotenoid concentrations were reassessed 8 weeks after the normative messages were presented or withheld. Skin carotenoid levels of those in the Manipulated Normative group increased significantly more than did scores of those in the Control group (t (126) = 3.74, p < 0.001; d = 0.67), but these students' self-reported FV intake did not increase. This finding suggests normative messaging can influence behavior for up to 8 weeks, but future research must better evaluate if the increase in skin carotenoids reflects increased FV consumption, increased consumption of carotenoid-containing FV (with decreased consumption of other FV), or is accounted for by some other behavior change (e.g., increased use of supplements). These findings support further exploration of normative messaging as a technique for producing the long-term behavior change needed to impact public health.
[Mh] Termos MeSH primário: Carotenoides/metabolismo
Frutas
Dieta Saudável
Cooperação do Paciente
Pele/metabolismo
Normas Sociais
Verduras
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/metabolismo
Comportamento de Escolha
Feminino
Preferências Alimentares
Dieta Saudável/psicologia
Seres Humanos
Internet
Masculino
Inquéritos Nutricionais
Ciências da Nutrição/educação
Cooperação do Paciente/psicologia
Estudo de Prova de Conceito
Estudantes
Universidades
Utah
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biomarkers); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  4 / 15737 MEDLINE  
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[PMID]:29349456
[Au] Autor:Johnson QR; Mostofian B; Fuente Gomez G; Smith JC; Cheng X
[Ad] Endereço:National Institute for Mathematical and Biological Synthesis, University of Tennessee, Knoxville, TN 37996, USA.
[Ti] Título:Effects of carotenoids on lipid bilayers.
[So] Source:Phys Chem Chem Phys;20(5):3795-3804, 2018 Jan 31.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes. However, the molecular details of how carotenoids modulate the physical properties of biomembranes are unknown. To this end, we have conducted a series of molecular dynamics simulations of different biologically-relevant membranes in the presence of carotenoids. The carotenoid effect on the membrane was found to be specific to the identity of the carotenoid and the composition of the membrane itself. Therefore, different classes of carotenoids produce a different effect on the membrane, and different membrane phases are affected differently by carotenoids. It is apparent from our data that carotenoids do trigger the bilayer to become thinner. The mechanism by which this occurs depends on two competing factors, the ability of the lipid tails of opposing monolayers to either (1) compress or (2) interdigitate as the bilayer condenses. Indeed, carotenoids directly influence the physical properties via these two mechanisms, thus compacting the bilayer. However, the degree to which these competing mechanisms are utilized depends on the bilayer phase and the carotenoid identity.
[Mh] Termos MeSH primário: Carotenoides/metabolismo
Bicamadas Lipídicas/metabolismo
[Mh] Termos MeSH secundário: Carotenoides/química
Colesterol/química
Bicamadas Lipídicas/química
Simulação de Dinâmica Molecular
Fosfatidilcolinas/química
Zeaxantinas/química
Zeaxantinas/metabolismo
beta Caroteno/química
beta Caroteno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipid Bilayers); 0 (Phosphatidylcholines); 0 (Zeaxanthins); 01YAE03M7J (beta Carotene); 043IPI2M0K (1,2-distearoyllecithin); 36-88-4 (Carotenoids); 97C5T2UQ7J (Cholesterol); TE895536Y5 (1-palmitoyl-2-oleoylphosphatidylcholine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180120
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp07126d


  5 / 15737 MEDLINE  
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[PMID]:28943375
[Au] Autor:Emerling CA
[Ad] Endereço:Museum of Vertebrate Zoology, University of California Berkeley, Berkeley, CA, USA. Electronic address: christopher.emerling@umontpellier.fr.
[Ti] Título:Independent pseudogenization of CYP2J19 in penguins, owls and kiwis implicates gene in red carotenoid synthesis.
[So] Source:Mol Phylogenet Evol;118:47-53, 2018 Jan.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carotenoids have important roles in bird behavior, including pigmentation for sexual signaling and improving color vision via retinal oil droplets. Yellow carotenoids are diet-derived, but red carotenoids (ketocarotenoids) are typically synthesized from yellow precursors via a carotenoid ketolase. Recent research on passerines has provided evidence that a cytochrome p450 enzyme, CYP2J19, is responsible for this reaction, though it is unclear if this function is phylogenetically restricted. Here I provide evidence that CYP2J19 is the carotenoid ketolase common to Aves using the genomes of 65 birds and the retinal transcriptomes of 15 avian taxa. CYP2J19 is functionally intact and robustly transcribed in all taxa except for several species adapted to foraging in dim light conditions. Two penguins, an owl and a kiwi show evidence of genetic lesions and relaxed selection in their genomic copy of CYP2J19, and six owls show evidence of marked reduction in CYP2J19 retinal transcription compared to nine diurnal avian taxa. Furthermore, one of the owls appears to transcribe a CYP2J19 pseudogene. Notably, none of these taxa are known to use red carotenoids for sexual signaling and several species of owls and penguins represent the only birds known to completely lack red retinal oil droplets. The remaining avian taxa belong to groups known to possess red oil droplets, are known or expected to deposit red carotenoids in skin and/or plumage, and/or frequently forage in bright light. The loss and reduced expression of CYP2J19 is likely an adaptation to maximize retinal sensitivity, given that oil droplets reduce the amount of light available to the retina.
[Mh] Termos MeSH primário: Aves/classificação
Carotenoides/biossíntese
Sistema Enzimático do Citocromo P-450/genética
Spheniscidae/classificação
Estrigiformes/classificação
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Aves/genética
Sistema Enzimático do Citocromo P-450/classificação
Bases de Dados Genéticas
Evolução Molecular
Filogenia
Retina/metabolismo
Spheniscidae/metabolismo
Estrigiformes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
36-88-4 (Carotenoids); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


  6 / 15737 MEDLINE  
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[PMID]:29395084
[Au] Autor:Park JH; Jung S
[Ad] Endereço:School of Life Sciences and Biotechnology, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, South Korea.
[Ti] Título:Perturbations in carotenoid and porphyrin status result in differential photooxidative stress signaling and antioxidant responses.
[So] Source:Biochem Biophys Res Commun;496(3):840-845, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We examined differential photooxidative stress signaling and antioxidant responses in rice plants treated with norflurazon (NF) and oxyfluorfen (OF), which are inhibitors of carotenoid and porphyrin biosynthesis, respectively. Plants treated with OF markedly increased levels of cellular leakage and malondialdehyde, compared with NF-treated plants, showing that OF plants suffered greater oxidative damage with respect to membrane integrity. The enhanced production of H O in response to OF, but not NF, indicates the important role of H O in activation of photooxidative stress signaling in OF plants. In response to NF and OF, the increased levels of free salicylic acid as well as maintenance of the redox ratio of ascorbate and glutathione pools to a certain level are considered to be crucial factors in the protection against photooxidation. Plants treated with OF greatly up-regulated catalase (CAT) activity and Cat transcript levels, compared with NF-treated plants. Interestingly, NF plants showed no noticeable increase in oxidative metabolism, although they did show considerable increases in ascorbate peroxidase (APX) and peroxidase activities and transcript levels of APX, as in OF plants. Our results suggest that perturbations in carotenoid and porphyrin status by NF and OF can be sensed by differential photooxidative stress signaling, such as that involving H O , redox state of ascorbate and glutathione, and salicylic acid, which may be responsible for at least part of the induction of ROS-scavenging enzymes.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Carotenoides/metabolismo
Transdução de Sinal Luminoso/fisiologia
Oryza/fisiologia
Estresse Oxidativo/fisiologia
Porfirinas/metabolismo
Estresse Fisiológico/fisiologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Luz
Transdução de Sinal Luminoso/efeitos da radiação
Oryza/efeitos da radiação
Estresse Oxidativo/efeitos da radiação
Dose de Radiação
Estresse Fisiológico/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Porphyrins); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE


  7 / 15737 MEDLINE  
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[PMID]:29241956
[Au] Autor:Abd Wahib SM; Wan Ibrahim WA; Sanagi MM; Kamboh MA; Abdul Keyon AS
[Ad] Endereço:Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 UTM Johor Bahru, Johor, Malaysia.
[Ti] Título:Magnetic sporopollenin-cyanopropyltriethoxysilane-dispersive micro-solid phase extraction coupled with high performance liquid chromatography for the determination of selected non-steroidal anti-inflammatory drugs in water samples.
[So] Source:J Chromatogr A;1532:50-57, 2018 Jan 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A facile dispersive-micro-solid phase extraction (D-µ-SPE) method coupled with HPLC for the analysis of selected non-steroidal anti-inflammatory drugs (NSAIDs) in water samples was developed using a newly prepared magnetic sporopollenin-cyanopropyltriethoxysilane (MS-CNPrTEOS) sorbent. Sporopollenin homogenous microparticles of Lycopodium clavatum spores possessed accessible functional groups that facilitated surface modification. Simple modification was performed by functionalization with 3-cyanopropyltriethoxysilane (CNPrTEOS) and magnetite was introduced onto the biopolymer to simplify the extraction process. MS-CNPrTEOS was identified by infrared spectrometrywhile the morphology and the magnetic property were confirmed by scanning electron microscopy (SEM) and vibrating sample magnetometer (VSM), respectively. To maximize the extraction performance of ketoprofen, ibuprofen, diclofenac and mefenamic acid using the proposed MS-CNPrTEOS, important D-µ-SPE parameters were comprehensively optimized. The optimum extraction conditions were sorbent amount, 40 mg; extraction time, 5 min; desorption time; 5 min; sample volume, 15 mL; sample pH 2.0; and salt addition, 2.5% (w/v). The feasibility of the developed method was evaluated using spiked tap water, lake water, river water and waste water samples. Results showed that ketoprofen and ibuprofen were linear in the range of 1.0-1000 µg L whilst diclofenac and mefenamic acid were linear in the range 0.8-500 µg L . The results also showed good detection limits for the studied NSAIDs in the range of 0.21-0.51 µg L and good recoveries for spiked water samples in the range of 85.1-106.4%. The MS-CNPrTEOS proved a promising dispersive sorbent and applicable to facile and rapid assay of NSAIDs in water samples.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/análise
Cromatografia Líquida de Alta Pressão
Monitoramento Ambiental/métodos
Água Doce/química
Microextração em Fase Sólida
[Mh] Termos MeSH secundário: Biopolímeros/análise
Biopolímeros/química
Carotenoides/química
Ibuprofeno/análise
Cetoprofeno/análise
Limite de Detecção
Magnetismo
Águas Residuais/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Biopolymers); 0 (Waste Water); 0 (Water Pollutants, Chemical); 12712-72-0 (sporopollenin); 36-88-4 (Carotenoids); 90Y4QC304K (Ketoprofen); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  8 / 15737 MEDLINE  
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[PMID]:29217355
[Au] Autor:Wang X; Zhang G; Qiao Y; Feng C; Zhao X
[Ad] Endereço:Department of Anesthesiology, The Second Hospital of Shandong University, 247 Bei Yuan Street, Jinan 250033, China.
[Ti] Título:Crocetin attenuates spared nerve injury-induced neuropathic pain in mice.
[So] Source:J Pharmacol Sci;135(4):141-147, 2017 Dec.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Crocetin is the main component of saffron and exhibits anti-oxidative and anti-inflammatory effects. Neuroinflammation and oxidative stress have been recognized to play a crucial role in the pathogenesis of neuropathic pain. We investigated the effect of crocetin in a mouse model with neuropathic pain induced by spared nerve injury (SNI). Crocetin was intrathecally perfused at various doses for up to 12 days starting 3 days before the surgery. Behavioral tests were performed to determine pain sensitivity. The concentrations of proinflammatory cytokines tumor necrosis factor (TNF-α) and interleukin-1ß (IL-1ß) were measured to assess neuroinflammation. In addition, the enzymatic activity of superoxide dismutase (SOD) was measured to reveal the oxidative stress level. We found that repeated treatment with crocetin dose-dependently attenuated mechanical and thermal allodynia in SNI mice. In addition, treatment with high dose of crocetin reduced SNI-induced increase of TNF-α and IL-1ß. Crocetin also restored the activity of mitochondrial MnSOD which was reduced in the sciatic nerve and the spinal cord of SNI mice. Collectively, our data demonstrate that crocetin effectively attenuates the neuropathic pain and significantly suppresses oxidative stress and neuroinflammation in the SNI mouse model, supporting the potential of crocetin in the treatment against neuropathic pain.
[Mh] Termos MeSH primário: Carotenoides/administração & dosagem
Carotenoides/farmacologia
Neuralgia/tratamento farmacológico
Neuralgia/etiologia
Traumatismos dos Nervos Periféricos/complicações
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios
Antioxidantes
Biomarcadores
Carotenoides/isolamento & purificação
Crocus/química
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mediadores da Inflamação/metabolismo
Interleucina-1beta/metabolismo
Masculino
Camundongos Endogâmicos
Neuralgia/diagnóstico
Neuralgia/metabolismo
Estresse Oxidativo
Nervo Isquiático/metabolismo
Medula Espinal
Superóxido Dismutase
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Biomarkers); 0 (Inflammation Mediators); 0 (Interleukin-1beta); 0 (Tumor Necrosis Factor-alpha); 20TC155L9C (crocetin); 36-88-4 (Carotenoids); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171209
[St] Status:MEDLINE


  9 / 15737 MEDLINE  
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[PMID]:29224342
[Au] Autor:Iwai R; Han C; Govindam SVS; Ojika M
[Ad] Endereço:Graduate School of Bioagricultural Sciences, Nagoya University , Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
[Ti] Título:Lycosides, Unusual Carotenoid-Derived Terpenoid Glycosides from a Vegetable Juice, Inhibit Asexual Reproduction of the Plant Pathogen Phytophthora.
[So] Source:J Agric Food Chem;66(1):163-169, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vegetable juices, typical culture media for the plant pathogen Phytophthora, effectively induce its asexual reproduction (zoosporangia formation). However, some chromatographic fractions from a vegetable juice were found to inhibit asexual reproduction. Bioassay-guided chromatographic steps led to the isolation of four novel compounds, named lycosides A-D, 1-4, that could be metabolic products from a carotenoid. They showed 50% inhibitory activity against the asexual reproduction of P. capsici at 2.1-7.6 µM. The structure-activity relationship and the universality of the inhibitory activity within the Phytophthora genus were also investigated. In addition, the quantitative analysis of lycosides in fresh vegetables and vegetable juices revealed that tomato is the source of these active substances. These food-derived chemicals could help provide safe agents to control the outbreak of the agricultural pest Phytophthora in fields.
[Mh] Termos MeSH primário: Sucos de Frutas e Vegetais
Glicosídeos/farmacologia
Phytophthora/efeitos dos fármacos
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Carotenoides/isolamento & purificação
Carotenoides/farmacologia
Glicosídeos/química
Glicosídeos/isolamento & purificação
Lycopersicon esculentum/química
Estrutura Molecular
Phytophthora/patogenicidade
Phytophthora/fisiologia
Reprodução Assexuada/efeitos dos fármacos
Relação Estrutura-Atividade
Terpenos/química
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Terpenes); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04766


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[PMID]:29319312
[Au] Autor:Huang W; Lin Y; He M; Gong Y; Huang J
[Ad] Endereço:Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.
[Ti] Título:Induced High-Yield Production of Zeaxanthin, Lutein, and ß-Carotene by a Mutant of Chlorella zofingiensis.
[So] Source:J Agric Food Chem;66(4):891-897, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural resources of zeaxanthin are extremely limited. A Chlorella zofingiensis mutant (CZ-bkt1), which could accumulate high amounts of zeaxanthin, was generated and characterized. CZ-bkt1 was achieved by treating the algal cells with a chemical mutagen followed by a color-based colony-screening approach. CZ-bkt1 was found to consist of a dysfunctional carotenoid ketolase, leading to the accumulation of zeaxanthin rather than to its downstream ketocarotenoid astaxanthin. Light irradiation, glucose, NaCl, and nitrogen deficiency all induced CZ-bkt1 to accumulate zeaxanthin. CZ-bkt1 accumulated zeaxanthin up to 7.00 ± 0.82 mg/g when induced by high-light irradiation and nitrogen deficiency and up to 36.79 ± 2.23 mg/L by additional feeding with glucose. Furthermore, in addition to zeaxanthin, CZ-bkt1 also accumulated high amounts of ß-carotene (7.18 ± 0.72 mg/g or 34.64 ± 1.39 mg/L) and lutein (13.81 ± 1.23 mg/g or 33.97 ± 2.61 mg/L). CZ-bkt1 is the sole species up to date with the ability to accumulate high amounts of the three carotenoids that are essential for human health.
[Mh] Termos MeSH primário: Chlorella/genética
Chlorella/metabolismo
Luteína/biossíntese
Zeaxantinas/biossíntese
beta Caroteno/biossíntese
[Mh] Termos MeSH secundário: Carotenoides/metabolismo
Códon sem Sentido
Mutagênese
Mutação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Nonsense); 0 (Zeaxanthins); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); X72A60C9MT (Lutein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05400



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