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[PMID]:29377934
[Au] Autor:Soudy ID; Minet-Quinard R; Mahamat AD; Ngoua HF; Izzedine AA; Tidjani A; Ngo Bum E; Lambert C; Pereira B; Desjeux JF; Sapin V
[Ad] Endereço:Institut National Supérieur des Sciences et Techniques d'Abéché (INSTA-Tchad), Abéché, Tchad.
[Ti] Título:Vitamin A status in healthy women eating traditionally prepared spirulina (Dihé) in the Chad Lake area.
[So] Source:PLoS One;13(1):e0191887, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chad Lake is a central place in a region with a high prevalence of vitamin A deficiency. Spirulina, a natural source of ß-carotene, is traditionally produced and eaten as "Dihé" around Chad Lake. ß-carotene spirulina has been found to have a high conversion factor to retinol. The aim of the study was to assess if the retinol status between healthy women eating spirulina Dihé daily (SPI+) and not (SPI-) in the Chad Lake area was different. METHODS: This study was observational: 88 healthy women were recruited and selected according to clinical criteria and their willingness to participate. They were divided in two groups according to their Dihé daily consumption: those who eat Dihé (SPI+; n = 35) and those who do not (SPI-; n = 35). After anthropometric and dietary assessments, blood retinol, ß-carotene, retinol binding, and inflammatory/nutritional proteins were measured. RESULTS: The diet between groups was identical, except for ß-carotene consumption, which was higher in SPI+ than in SPI- (10.8 vs. 1.8 mg/day). The serum retinol and ß-carotene concentrations were significantly higher in SPI+ than in SPI- at 1.26 ± 0.36 µmol/l versus 1.03 ± 0.31 µmol/l (p = 0.008) and 0.59 ±0.37 µmol/l versus 0.46± 0.31 µmol/l (p = 0.04), respectively. Seventy-seven percent of SPI+ versus 29% of SPI- had an adequate blood retinol value (p = 0.01). CONCLUSION: The results confirm that ß-carotene in spirulina is an effective positive modulator of blood retinol status. Dihé is a potential natural source of ß-carotene to achieve a proper vitamin A status in healthy women living near Chad Lake.
[Mh] Termos MeSH primário: Spirulina
Vitamina A/sangue
[Mh] Termos MeSH secundário: Adulto
Chade
Dieta
Feminino
Seres Humanos
Lagos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
11103-57-4 (Vitamin A)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191887


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[PMID]:29390321
[Au] Autor:Bichon A; Aubry C; Benarous L; Drouet H; Zandotti C; Parola P; Lagier JC
[Ad] Endereço:Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU Méditerranée-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
[Ti] Título:Case report: Ribavirin and vitamin A in a severe case of measles.
[So] Source:Medicine (Baltimore);96(50):e9154, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Despite a vaccine being widely available, measles continues to occur frequently, with sometimes lethal consequences. PATIENTS CONCERNS: The mortality rate reaches 35% and measles represents 44% of the 1.4 million deaths which are due to preventable diseases. Severe forms of measles are reported, mainly in young, unvaccinated adults, and in specific populations. The risk factors for severe measles include no or incomplete vaccination and vitamin A deficiency. Apart from secondary measles-related infections, severe measles is mainly represented by neurological, respiratory, and digestive symptoms. DIAGNOSES: Strengthening the hypothesis that there is a link between vitamin A deficiency and severe measles in this paper we report the case of a 25-year-old unvaccinated man hospitalized for severe and complicated measles. OUTCOMES: The evolution was good after administration of intramuscular vitamin A as well as intravenous ribavirin. LESSONS: Measles remains a fatal and serious disease. The early use of ribavirin and vitamin A shows significant improvements regarding morbimortality and should be systematic in severe cases.
[Mh] Termos MeSH primário: Antivirais/uso terapêutico
Sarampo/prevenção & controle
Ribavirina/uso terapêutico
Vitamina A/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Masculino
Sarampo/complicações
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 11103-57-4 (Vitamin A); 49717AWG6K (Ribavirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009154


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[PMID]:29443744
[Au] Autor:Bai YJ; Dai RJ
[Ad] Endereço:5th Department of Pediatric.
[Ti] Título:Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma: A case-control study.
[So] Source:Medicine (Baltimore);97(7):e9830, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aims to explore the relationship between serum vitamin A and 25-hydroxyvitamin D3 (25OHD3) levels with pulmonary function and quality of life (QOL) in children with stable asthma. METHODS: A total of 117 cases of children with stable asthma were assigned into the case group and 129 healthy children underwent physical examination during the same period into the control group. Electrochemiluminescence was employed to determine serum vitamin A and 25OHD3 levels. The children with stable asthma were further divided into the mild, moderate, and severe groups according to their degree of asthma. A pulmonary function meter was used to assess the pulmonary function indexes: percentage of forced expiratory volume in 1 sec/predictive value (FEV1%pred), forced vital capacity (FVC), forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF), and maximal voluntary ventilation (MVV). The children's quality (QOL) of life with asthma was evaluated by their activities of daily living (ADLs) and Medical Research Council (MRC) scores. Pearson correlation analysis was applied to analyze the correlations of serum vitamin A and 25OHD3 levels with FEV1%pred, FVC, FEV1/FVC, PEF, MVV, ADL, and MRC. RESULTS: Serum vitamin A and 25OHD3 levels were lower in children with stable asthma than those who were in the control group (P < .05). The severe group showed the lowest FEV1%pred, FVC, FEV1/FVC, PEF, MVV, and ADL scores, and the highest MRC score compared to the mild and moderate groups (all P < .05). Serum vitamin A and 25OHD3 levels were positively correlated with pulmonary function and ADL score in children with stable asthma, while serum vitamin A and 25OHD3 levels were negatively correlated with MRC score (all P < .05). In the case group, serum vitamin A and 25OHD3 levels were positively correlated with serum calcium and phosphorus levels (all P < .05). CONCLUSION: These findings indicate that increased serum vitamin A and 25OHD3 levels reflect good pulmonary function and good QOL in children with stable asthma.
[Mh] Termos MeSH primário: Asma/sangue
Qualidade de Vida
Vitamina A/sangue
Vitamina D/análogos & derivados
[Mh] Termos MeSH secundário: Atividades Cotidianas
Asma/fisiopatologia
Biomarcadores/sangue
Estudos de Casos e Controles
Criança
Feminino
Volume Expiratório Forçado
Seres Humanos
Pulmão/fisiopatologia
Masculino
Valor Preditivo dos Testes
Testes de Função Respiratória
Capacidade Vital
Vitamina D/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 11103-57-4 (Vitamin A); 1406-16-2 (Vitamin D); 64719-49-9 (25-hydroxyvitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009830


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[PMID]:29377658
[Au] Autor:Borovik TE; Guseva IM; Semenova NN; Zvonkova NG; Lukoyanova OL; Zakharova IN; Stepanova TN; Surzhik AV; Mozzhukhina LI; Rusova TV
[Ti] Título:Characteristics of the nutrition organization and nutrient consumption in toddlers' living in the Central Federal District, Russian Federation (Moscow, Ivanovo, Yaroslavl).
[So] Source:Vopr Pitan;85(6):86-94, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A multicenter cross-sectional study with the participation of 356 healthy children aged 1 to 3 years from the cities of the Central Federal District: Moscow (n=106), Ivanovo (n=126), Yaroslavl (n=124) has been carried out. Questionnaire method, the method of 24-hour diet recall for 3 days (2 weekdays and 1 weekend) and the method of diary recording of food intake were used. The average daily volumes of food were consistent with the recommended age norms only in 31.2% of the surveyed children; after 1 year of life children actively started to transfer to nutrition from the family table and only 51.7% of children continued to receive individually prepared for baby food. The recommended dietary allowances were inadequate in macro- and micronutrients: 48.6% of all children received excessive amounts of protein and fat, and 74.1% were less in carbohydrates. The consumption of vitamins D and A and minerals (calcium, iron and zinc) did not correspond to existing recommendations in the majority of cases: only 10-30% of the examined children received physiological norms of vitamins from food and 13-34% - some minerals and trace elements. These results indicate that the nutrition of young children living in the Central Federal District is imbalanced on daily caloric, macro- and micronutrient composition, does not fully meet the requirements of the balanced diet and needs serious optimization.
[Mh] Termos MeSH primário: Desenvolvimento Infantil/fisiologia
Fenômenos Fisiológicos da Nutrição Infantil/fisiologia
Ingestão de Alimentos/fisiologia
Ingestão de Energia/fisiologia
Fórmulas Infantis
Inquéritos e Questionários
[Mh] Termos MeSH secundário: Pré-Escolar
Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/análise
Feminino
Seres Humanos
Lactente
Masculino
Minerais/administração & dosagem
Minerais/análise
Moscou
Vitamina A/administração & dosagem
Vitamina A/análise
Vitamina D/administração & dosagem
Vitamina D/análise
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Dietary Proteins); 0 (Minerals); 11103-57-4 (Vitamin A); 1406-16-2 (Vitamin D)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  5 / 18302 MEDLINE  
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[PMID]:29363932
[Au] Autor:Beketova NA; Kodentsova VM; Vrzhesinskaya OA; Kosheleva OV; Pereverzeva OG; Solntseva TN; Pogozheva AV; Khanferyan RA; Berketova LV; Lipatova LP
[Ti] Título:[Estimation of vitamin status of moscow student according to data on vitamins intake and their levels in blood].
[So] Source:Vopr Pitan;84(5):64-75, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Supply with vitamins C, A, E and B2 of 61 high school students (38 girls and 23 boys, aged 18­22 years, body mass index ­ 23.0±0.6 kg/m2) by means of determination of blood plasma concentration of ascorbic acid, retinol and carotenoids, tocopherols and riboflavin has been investigated in the period from May to September. All students were well supplied with vitamin C (only 2 boys had a reduced level of ascorbic acid) and vitamin A. Decreased level of carotenoids was more common in boys (48 versus 24% in girls). 20% of the students were insufficiently supplied with vitamin E, 38% ­ with vitamin B2. 39% of students (50% girls and 22% boys) were adequately provided with all studied vitamins. 5% of the students had a combined deficiency of 3 vitamins, 20% ­ 2 vitamins. Student's sufficiency with vitamins B2, C, A, E, carotenoids did not depend on the season. Diet intake of vitamins C, A, carotenoids and vitamin B2 has been calculated basing on the data on the frequency of food consumption during the previous month. Reduced consumption relatively to the Russia RDA of vitamins В2, C and А took place in 63, 54 and 46% of the students respectively. The lack of vitamin B2 in the diet was most pronounced, the value of probabilistic risk corresponded to the average level in 34% of students. Average probabilistic risk of inadequate intake of vitamin A was present in 17% of students, vitamin C ­ 6%. Coincidence of the results of vitamin C and A status assessment obtained by calculation of vitamin diet intake and by biochemical methods (concentration of vitamins in the blood plasma) was 94 and 83%. These methods are interchangeable if you select the value of the average probability of risk failure intake of these vitamins as a criterion. Proportion of coinciding results of the estimation of vitamin B2 status was 56%. Special well-designed studies on larger sample surveyed are needed for the final output of the interchangeability of methods to assess riboflavin status.
[Mh] Termos MeSH primário: Suplementos Nutricionais
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ácido Ascórbico/administração & dosagem
Ácido Ascórbico/farmacocinética
Feminino
Seres Humanos
Masculino
Estudantes
Vitamina A/administração & dosagem
Vitamina A/farmacocinética
Vitaminas/administração & dosagem
Vitaminas/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vitamins); 11103-57-4 (Vitamin A); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


  6 / 18302 MEDLINE  
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[PMID]:28449319
[Au] Autor:Janmohamed A; Doledec D
[Ad] Endereço:Independent Consultant, Mississauga, Canada.
[Ti] Título:Comparison of administrative and survey data for estimating vitamin A supplementation and deworming coverage of children under five years of age in Sub-Saharan Africa.
[So] Source:Trop Med Int Health;22(7):822-829, 2017 07.
[Is] ISSN:1365-3156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare administrative coverage data with results from household coverage surveys for vitamin A supplementation (VAS) and deworming campaigns conducted during 2010-2015 in 12 African countries. METHODS: Paired t-tests examined differences between administrative and survey coverage for 52 VAS and 34 deworming dyads. Independent t-tests measured VAS and deworming coverage differences between data sources for door-to-door and fixed-site delivery strategies and VAS coverage differences between 6- to 11-month and 12- to 59-month age group. RESULTS: For VAS, administrative coverage was higher than survey estimates in 47 of 52 (90%) campaign rounds, with a mean difference of 16.1% (95% CI: 9.5-22.7; P < 0.001). For deworming, administrative coverage exceeded survey estimates in 31 of 34 (91%) comparisons, with a mean difference of 29.8% (95% CI: 16.9-42.6; P < 0.001). Mean ± SD differences in coverage between administrative and survey data were 12.2% ± 22.5% for the door-to-door delivery strategy and 25.9% ± 24.7% for the fixed-site model (P = 0.06). For deworming, mean ± SD differences in coverage between data sources were 28.1% ± 43.5% and 33.1% ± 17.9% for door-to-door and fixed-site distribution, respectively (P = 0.64). VAS administrative coverage was higher than survey estimates in 37 of 49 (76%) comparisons for the 6- to 11-month age group and 45 of 48 (94%) comparisons for the 12- to 59-month age group. CONCLUSION: Reliance on health facility data alone for calculating VAS and deworming coverage may mask low coverage and prevent measures to improve programmes. Countries should periodically validate administrative coverage estimates with population-based methods.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Suplementos Nutricionais/estatística & dados numéricos
Pesquisas sobre Serviços de Saúde/estatística & dados numéricos
Helmintíase/tratamento farmacológico
Deficiência de Vitamina A/terapia
Vitamina A/uso terapêutico
[Mh] Termos MeSH secundário: África ao Sul do Saara
Pré-Escolar
Feminino
Pesquisas sobre Serviços de Saúde/métodos
Seres Humanos
Lactente
Masculino
Vitaminas
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Vitamins); 11103-57-4 (Vitamin A)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1111/tmi.12883


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[PMID]:29235335
[Au] Autor:Shmarakov IO; Borschovetska VL; Ivanishchuk LP; Marchenko MM
[Ti] Título:Hepatotoxicity of bisphenol A under conditions of differential supplementation with retinoids.
[So] Source:Ukr Biochem J;88(3):99-105, 2016 May-Jun.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:Classical xenoestrogenic in vivo effects of bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) are well-described in the literature, however the molecular mechanisms of BPA-induced hepatotoxicity are not fully characterized. The work is aimed to assess biochemical markers of BPA induced hepatotoxicity under conditions of differential supplementation with retinoids. We demonstrate that the absence of hepatic retinyl esters as the main form of vitamin A storage provides for a resistance to BPA induced liver damage. Retinoid supplementation increases the hepatotoxic effects of bisphenol A, evidenced in higher indexes of oxidative damage of lipids, proteins and non-protein thiol groups as well as increase of serum alanine aminotransferase activity and myeloperoxidase activity in liver parenchyma. The absence of hepatotoxicity signs when hepatic retinoid stores are depleted and their presence during normal or excessive retinoid supplementation suggest that hepatic retinoid availability is one of the factors determining the hepatotoxicity of bisphenol A.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Disruptores Endócrinos/toxicidade
Fenóis/toxicidade
Vitamina A/análogos & derivados
Vitamina A/efeitos adversos
[Mh] Termos MeSH secundário: Aciltransferases/deficiência
Aciltransferases/genética
Alanina Transaminase/sangue
Alanina Transaminase/genética
Animais
Doença Hepática Induzida por Substâncias e Drogas/patologia
Expressão Gênica
Fígado/efeitos dos fármacos
Fígado/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Estresse Oxidativo
Peroxidase/genética
Peroxidase/metabolismo
Carbonilação Proteica/efeitos dos fármacos
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Vitamina A/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Phenols); 0 (Thiobarbituric Acid Reactive Substances); 11103-57-4 (Vitamin A); 3LE3D9D6OY (retinol acetate); EC 1.11.1.7 (Peroxidase); EC 2.3.- (Acyltransferases); EC 2.3.1.- (lecithin-retinol acyltransferase); EC 2.6.1.2 (Alanine Transaminase); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.03.099


  8 / 18302 MEDLINE  
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[PMID]:29242338
[Au] Autor:Duester G
[Ad] Endereço:Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. duester@sbpdiscovery.org.
[Ti] Título:Retinoic acid's reproducible future.
[So] Source:Science;358(6369):1395, 2017 12 15.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Vitamina A
[Mh] Termos MeSH secundário: Pesquisa Biomédica
Seres Humanos
Reprodutibilidade dos Testes
Transdução de Sinais
Vitamina A/metabolismo
Vitamina A/farmacologia
Vitamina A/fisiologia
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
11103-57-4 (Vitamin A)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1126/science.aar6752


  9 / 18302 MEDLINE  
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[PMID]:29199923
[Au] Autor:Villamor E; Marín C; Mora-Plazas M; Oliveros H
[Ad] Endereço:2Center for Human Growth and Development,University of Michigan,Ann Arbor,MI 48109,USA.
[Ti] Título:Micronutrient status in middle childhood and age at menarche: results from the Bogotá School Children Cohort.
[So] Source:Br J Nutr;118(12):1097-1105, 2017 Dec.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Childhood intake of animal foods is associated with age at first menstrual period (menarche). It is unknown whether the micronutrients present in these foods could explain this association. Our objective was to investigate the associations of micronutrient status biomarkers in middle childhood with age at menarche. We quantified circulating Hb, ferritin, mean corpuscular volume, Zn, vitamin B12, erythrocyte folate and retinol in 1464 pre-menarcheal girls aged 5-12 years in Bogotá, Colombia, and followed them for a median 5·7 years for the occurrence and date of menarche. We estimated median age at menarche and hazard ratios (HR) with 95 % CI by levels of each biomarker with use of Kaplan-Meier survival probabilities and Cox regression, respectively. Median age at menarche was 12·4 years. Middle childhood Hb was inversely related to age at menarche whereas plasma ferritin was positively associated with this outcome in a linear manner. HR of menarche for every 1 sd of Hb (11 g/l) and ferritin (23·2 µg/l) were 1·11 (95 % CI 1·04, 1·18; P=0·001) and 0·94 (95 % CI 0·88, 0·99; P=0·02), respectively, after adjustment for baseline age, C-reactive protein concentration, maternal age at menarche and parity and socioeconomic status. The association with ferritin was stronger in girls aged 9-10 years at baseline. Additional adjustment for baseline height- and BMI-for-age did not change the results. We conclude that higher Fe status in middle childhood is related to later age at menarche whereas Hb concentrations are inversely associated with age at onset of menses.
[Mh] Termos MeSH primário: Menarca/sangue
Micronutrientes/sangue
[Mh] Termos MeSH secundário: Biomarcadores/sangue
Índice de Massa Corporal
Proteína C-Reativa/metabolismo
Criança
Colômbia/epidemiologia
Eritrócitos/metabolismo
Feminino
Ferritinas/sangue
Ácido Fólico/sangue
Seguimentos
Hemoglobinas/metabolismo
Seres Humanos
Estudos Longitudinais
Micronutrientes/deficiência
Estado Nutricional
Modelos de Riscos Proporcionais
Fatores Socioeconômicos
Vitamina A/sangue
Vitamina B 12/sangue
Zinco/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hemoglobins); 0 (Micronutrients); 11103-57-4 (Vitamin A); 9007-41-4 (C-Reactive Protein); 9007-73-2 (Ferritins); 935E97BOY8 (Folic Acid); J41CSQ7QDS (Zinc); P6YC3EG204 (Vitamin B 12)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171227
[Lr] Data última revisão:
171227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114517003130


  10 / 18302 MEDLINE  
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[PMID]:28747484
[Au] Autor:Ford JL; Green JB; Lietz G; Oxley A; Green MH
[Ad] Endereço:Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA; and.
[Ti] Título:A Simple Plasma Retinol Isotope Ratio Method for Estimating ß-Carotene Relative Bioefficacy in Humans: Validation with the Use of Model-Based Compartmental Analysis.
[So] Source:J Nutr;147(9):1806-1814, 2017 09.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Provitamin A carotenoids are an important source of dietary vitamin A for many populations. Thus, accurate and simple methods for estimating carotenoid bioefficacy are needed to evaluate the vitamin A value of test solutions and plant sources. ß-Carotene bioefficacy is often estimated from the ratio of the areas under plasma isotope response curves after subjects ingest labeled ß-carotene and a labeled retinyl acetate reference dose [isotope reference method (IRM)], but to our knowledge, the method has not yet been evaluated for accuracy. Our objectives were to develop and test a physiologically based compartmental model that includes both absorptive and postabsorptive ß-carotene bioconversion and to use the model to evaluate the accuracy of the IRM and a simple plasma retinol isotope ratio [(RIR), labeled ß-carotene-derived retinol/labeled reference-dose-derived retinol in one plasma sample] for estimating relative bioefficacy. We used model-based compartmental analysis (Simulation, Analysis and Modeling software) to develop and apply a model that provided known values for ß-carotene bioefficacy. Theoretical data for 10 subjects were generated by the model and used to determine bioefficacy by RIR and IRM; predictions were compared with known values. We also applied RIR and IRM to previously published data. Plasma RIR accurately predicted ß-carotene relative bioefficacy at 14 d or later. IRM also accurately predicted bioefficacy by 14 d, except that, when there was substantial postabsorptive bioconversion, IRM underestimated bioefficacy. Based on our model, 1-d predictions of relative bioefficacy include absorptive plus a portion of early postabsorptive conversion. The plasma RIR is a simple tracer method that accurately predicts ß-carotene relative bioefficacy based on analysis of one blood sample obtained at ≥14 d after co-ingestion of labeled ß-carotene and retinyl acetate. The method also provides information about the contributions of absorptive and postabsorptive conversion to total bioefficacy if an additional sample is taken at 1 d.
[Mh] Termos MeSH primário: Isótopos/metabolismo
Modelos Biológicos
Provitaminas/metabolismo
Vitamina A/sangue
beta Caroteno/metabolismo
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Seres Humanos
Absorção Intestinal
Vitamina A/análogos & derivados
Vitamina A/biossíntese
Vitamina A/metabolismo
beta Caroteno/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Isotopes); 0 (Provitamins); 01YAE03M7J (beta Carotene); 11103-57-4 (Vitamin A); 3LE3D9D6OY (retinol acetate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.252361



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