[PMID]: | 28461109 |
[Au] Autor: | Amrouche K; Jamin C |
[Ad] Endereço: | UMR 1227, Lymphocytes B et Autoimmunité, Université de Brest, INSERM, Brest, France; LabEx IGO "Immunotherapy, Graft, Oncology", Brest, France. |
[Ti] Título: | Influence of drug molecules on regulatory B cells. |
[So] Source: | Clin Immunol;184:1-10, 2017 11. |
[Is] ISSN: | 1521-7035 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | By their suppressive functions, regulatory B (Breg) cells are considered as key elements in the control and development of various disease states. Many signals can induce Bregs in vivo and in vitro and often from heterogeneous populations. Several specific signals delivered in a timely immunological context contribute to the establishment of Bregs. These are endogenous and physiological signals or stimuli, widely discussed in the literature participating in the establishment of an effective immune response. However, exogenous signals, much less clearly identified can also be considered as Bregs inducers. These extrinsic signals are capable of directly or indirectly influencing the suppressive capacity of Bregs, but also their expansion and functional restoration in its absence. Faced with the excitement generated by the development of processes favoring the expansion of Bregs in mice for therapeutic purposes, the challenge today is to extrapolate such approaches in humans. This perspective may already be in effect. |
[Mh] Termos MeSH primário: |
Antineoplásicos/farmacologia Linfócitos B Reguladores/efeitos dos fármacos Imunossupressores/farmacologia Vitaminas/farmacologia
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[Mh] Termos MeSH secundário: |
Corticosteroides/farmacologia Animais Anticorpos Monoclonais Humanizados/farmacologia Fator Ativador de Células B/imunologia Linfócitos B Reguladores/imunologia Antígenos CD40/imunologia Citocinas/imunologia Seres Humanos Metotrexato/farmacologia Ácido Micofenólico/farmacologia Pirróis/farmacologia Quinazolinas/farmacologia Receptores de Antígenos de Linfócitos B/imunologia Semaforinas/farmacologia Sirolimo/farmacologia Receptores Toll-Like/imunologia Tretinoína/farmacologia Vitamina D/farmacologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Adrenal Cortex Hormones); 0 (Antibodies, Monoclonal, Humanized); 0 (Antineoplastic Agents); 0 (B-Cell Activating Factor); 0 (CD40 Antigens); 0 (Cytokines); 0 (Immunosuppressive Agents); 0 (Pyrroles); 0 (Quinazolines); 0 (Receptors, Antigen, B-Cell); 0 (Semaphorins); 0 (Toll-Like Receptors); 0 (Vitamins); 1406-16-2 (Vitamin D); 5688UTC01R (Tretinoin); 7I279E1NZ8 (sotrastaurin); HU9DX48N0T (Mycophenolic Acid); I031V2H011 (tocilizumab); W36ZG6FT64 (Sirolimus); YL5FZ2Y5U1 (Methotrexate) |
[Em] Mês de entrada: | 1711 |
[Cu] Atualização por classe: | 180206 |
[Lr] Data última revisão:
| 180206 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 170503 |
[St] Status: | MEDLINE |
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