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[PMID]:29188253
[Au] Autor:Takaya T; Anan M; Iwata K
[Ad] Endereço:Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan. tomohisa.takaya@gakushuin.ac.jp koichi.iwata@gakushuin.ac.jp.
[Ti] Título:Vibrational relaxation dynamics of ß-carotene and its derivatives with substituents on terminal rings in electronically excited states as studied by femtosecond time-resolved stimulated Raman spectroscopy in the near-IR region.
[So] Source:Phys Chem Chem Phys;20(5):3320-3327, 2018 Jan 31.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The electronic and vibrational relaxation of carotenoids is one of the key processes in the protection of living cells as well as in the functions of proteins involved in photosynthesis. In this study, the electronic and vibrational relaxation dynamics of ß-carotene and its derivatives with substituents on the terminal rings is investigated using femtosecond time-resolved absorption and stimulated Raman spectroscopy in the near-IR region. The carbonyl substituent induces low-frequency shifts of the steady-state and transient absorption bands, decreases of the excited-state lifetimes and the acceleration of vibrational relaxation of the conjugated main chain, whereas the hydroxyl substituent only slightly affects them. The effects of the carbonyl group in the electronic relaxation dynamics are explained well by the lengthening of effective conjugation by the carbonyl group through a partial conjugation between the main chain and the terminal ring. Time-resolved near-IR stimulated Raman spectroscopy demonstrates the significance of the peripheral substitution with the carbonyl group for the vibrational energy relaxation of ß-carotene derivatives in the lowest excited singlet state.
[Mh] Termos MeSH primário: beta Caroteno/análogos & derivados
[Mh] Termos MeSH secundário: Acetona/química
Cantaxantina/química
Espectrofotometria
Análise Espectral Raman
Xantofilas/química
Zeaxantinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Xanthophylls); 0 (Zeaxanthins); 01YAE03M7J (beta Carotene); 1364PS73AF (Acetone); 4C3C6403MU (Canthaxanthin); 8XPW32PR7I (astaxanthine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1039/c7cp06343a


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[PMID]:28515376
[Au] Autor:Maoka T; Sato W; Nagai H; Takahashi T
[Ad] Endereço:Research Institute for Production Development.
[Ti] Título:Carotenoids of Red, Brown, and Black Specimens of Plectropomus leopardus, the Coral Trout (Suziara in Japanese).
[So] Source:J Oleo Sci;66(6):579-584, 2017 Jun 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study investigated the carotenoids occurring in the integument of Plectropomus leopardus, the coral trout. For a red specimen, the major carotenoids included astaxanthin diester and monoester, as well as α-cryptoxanthin ester, tunaxanthin diester, adonixanthin diester, adonirubin ester, and adonirubin; for brown and black specimens, tunaxanthin diester was the main carotenoid. H-NMR and MS spectral analyses showed that docosahexaenoic acid was the sole fatty acid esterified with xanthophylls in the coral trout.
[Mh] Termos MeSH primário: Cor
Peixes/metabolismo
Xantofilas/análise
[Mh] Termos MeSH secundário: Animais
Cantaxantina/análogos & derivados
Carotenoides
Criptoxantinas
Ácidos Docosa-Hexaenoicos
Esterificação
Ésteres
Xantofilas/química
Xantofilas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Esters); 0 (Xanthophylls); 0 (adonirubin); 0 (adonixanthin); 25167-62-8 (Docosahexaenoic Acids); 36-88-4 (Carotenoids); 4C3C6403MU (Canthaxanthin); 8XPW32PR7I (astaxanthine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16179


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[PMID]:28192491
[Au] Autor:Sacco NJ; Bonetto MC; Cortón E
[Ad] Endereço:Laboratory of Biosensors and Bioanalysis (LABB), Departamento de Química Biológica and IQUIBICEN-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
[Ti] Título:Isolation and Characterization of a Novel Electrogenic Bacterium, Dietzia sp. RNV-4.
[So] Source:PLoS One;12(2):e0169955, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Electrogenic bacteria are organisms that can transfer electrons to extracellular electron acceptors and have the potential to be used in devices such as bioelectrochemical systems (BES). In this study, Dietzia sp. RNV-4 bacterium has been isolated and identified based on its biochemical, physiological and morphological characteristics, as well as by its 16S rRNA sequence analysis. Furthermore, the current density production and electron transfer mechanisms were investigated using bioelectrochemical methods. The chronoamperometric data showed that the biofilm of Dietzia sp. RNV-4 grew as the current increased with time, reaching a maximum of 176.6 ± 66.1 mA/m2 at the end of the experiment (7 d); this highly suggests that the current was generated by the biofilm. The main electron transfer mechanism, indicated by the cyclic voltammograms, was due to secreted redox mediators. By high performance liquid chromatography, canthaxanthin was identified as the main compound involved in charge transfer between the bacteria and the solid electrodes. Dietzia sp. RNV-4 was used as biological material in a microbial fuel cell (MFC) and the current density production was 299.4 ± 40.2 mA/m2. This is the first time that Dietzia sp. RNV-4 has been electrochemically characterized and identified as a new electrogenic strain.
[Mh] Termos MeSH primário: Actinobacteria/isolamento & purificação
Actinobacteria/metabolismo
Fontes de Energia Bioelétrica/microbiologia
Técnicas Eletroquímicas/métodos
[Mh] Termos MeSH secundário: Actinobacteria/genética
Biofilmes
Cantaxantina/metabolismo
Transporte de Elétrons
Elétrons
Microscopia Confocal
Microscopia Eletrônica de Varredura
Oxirredução
Filogenia
RNA Ribossômico 16S/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S); 4C3C6403MU (Canthaxanthin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170214
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169955


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[PMID]:27855894
[Au] Autor:Ravaghi M; Sinico C; Razavi SH; Mousavi SM; Pini E; Fadda AM
[Ad] Endereço:Department of Food Science, Engineering and Technology, Faculty of Agricultural Engineering and Technology, University of Tehran, P.O. Box 4111, Karaj 3158777871, Iran. Electronic address: ravaghi.maryam@gmail.com.
[Ti] Título:Proniosomal powders of natural canthaxanthin: Preparation and characterization.
[So] Source:Food Chem;220:233-241, 2017 Apr 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, canthaxanthin (CTX) was produced by Dietzia natronolimnaea HS-1 using beetroot molasses as substrate and used for encapsulation in proniosome powders after extraction, with the aim of improving its stability. Proniosome powders were prepared with an equimolar ratio of span 60/cholesterol and four different carriers, namely maltodextrin, mannitol, lactose and pullulan. The properties of these formulations as both proniosomal powders and resulted niosomal dispersions were evaluated. The type of carriers had significant effects on the micrometric properties of proniosome powders which were further confirmed by the results of SEM analysis. Although light and high temperatures affected the stability of CTX drastically, but encapsulation in proniosomes retarded its degradation. Among these samples, mannitol based proniosome powder (MAPP) produced small vesicles (mean diameter=175±3nmand polydispersity index=0.28±0.02) with the highest entrapment efficiency (74.1±2.7%). MAPP provided a promising formulation to increase CTX stability especially upon storage at high temperatures (45°C).
[Mh] Termos MeSH primário: Cantaxantina/química
Lipossomos/química
[Mh] Termos MeSH secundário: Química Farmacêutica
Manitol/química
Pós/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Liposomes); 0 (Powders); 3OWL53L36A (Mannitol); 4C3C6403MU (Canthaxanthin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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[PMID]:27615726
[Au] Autor:Tzanova M; Argirova M; Atanasov V
[Ad] Endereço:Department of Biochemistry, Microbiology and Physic, Faculty of Agriculture, Trakia University, Stara Zagora, Bulgaria.
[Ti] Título:HPLC Quantification of astaxanthin and canthaxanthin in Salmonidae eggs.
[So] Source:Biomed Chromatogr;31(4), 2017 Apr.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astaxanthin and canthaxanthin are naturally occurring antioxidants referred to as xanthophylls. They are used as food additives in fish farms to improve the organoleptic qualities of salmonid products and to prevent reproductive diseases. This study reports the development and single-laboratory validation of a rapid method for quantification of astaxanthin and canthaxanthin in eggs of rainbow trout (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis М.). An advantage of the proposed method is the perfect combination of selective extraction of the xanthophylls and analysis of the extract by high-performance liquid chromatography and photodiode array detection. The method validation was carried out in terms of linearity, accuracy, precision, recovery and limits of detection and quantification. The method was applied for simultaneous quantification of the two xanthophylls in eggs of rainbow trout and brook trout after their selective extraction. The results show that astaxanthin accumulations in salmonid fish eggs are larger than those of canthaxanthin. As the levels of these two xanthophylls affect fish fertility, this method can be used to improve the nutritional quality and to minimize the occurrence of the M74 syndrome in fish populations.
[Mh] Termos MeSH primário: Cantaxantina/análise
Cromatografia Líquida de Alta Pressão/métodos
Óvulo/química
Truta
[Mh] Termos MeSH secundário: Animais
Calibragem
Cantaxantina/isolamento & purificação
Fracionamento Químico
Feminino
Limite de Detecção
Oncorhynchus mykiss
Reprodutibilidade dos Testes
Xantofilas/análise
Xantofilas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Xanthophylls); 4C3C6403MU (Canthaxanthin); 8XPW32PR7I (astaxanthine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170317
[Lr] Data última revisão:
170317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3852


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[PMID]:27613855
[Au] Autor:Johnson-Dahl ML; Zuidhof MJ; Korver DR
[Ti] Título:The effect of maternal canthaxanthin supplementation and hen age on breeder performance, early chick traits, and indices of innate immune function.
[So] Source:Poult Sci;96(3):634-646, 2017 Mar 01.
[Is] ISSN:1525-3171
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hen age and nutrition influence chick innate immunity. The immunomodulatory antioxidant carotenoid canthaxanthin is transferred from the hen diet to the egg. Antioxidants could protect the chick from bactericidal oxidative species produced by the immune system. Broiler breeder hen diets were supplemented with 0 (Control), 6 (Low), or 12 (High) mg/kg canthaxanthin. Chick early growth and ex vivo innate immunity were measured at 31 to 33 (Early), 45 to 47 (Mid), and 57 to 59 (Late) wk of hen age. Escherichia coli (E. coli) bactericidal capacity, phagocyte activation (number of phagocytes containing at least one E. coli), phagocytic capacity (number of phagocytes containing one or more E. coli), and oxidative burst at 1 and 4 d of age were determined. Egg and chick liver canthaxanthin and chick plasma total antioxidant capacity were measured. Differences were considered significant at P ≤ 0.05. Breeder productivity was greatest for the Low hens; diet did not affect egg yolk, albumen, or shell proportions. Egg canthaxanthin increased with maternal supplementation and plateaued after 28 days, but was not affected by hen age. Chick liver canthaxanthin increased with maternal supplementation, but decreased as hens aged. Hen diet did not affect broiler chick performance to 21 days of age. Maternal canthaxanthin at 6 mg/kg increased chick E. coli bactericidal capacity and d 1 oxidative burst; phagocytosis was unaffected. E. coli bactericidal capacity decreased as hens aged, but increased from 1 to 4 d, indicating maturation of chick innate immunity. Plasma total antioxidant capacity at d 1 increased with maternal canthaxanthin in chicks from Mid and Late hens. Canthaxanthin possesses immuno-modulatory and antioxidant properties, and hen age affected chick innate immune development. Single-comb White Leghorn hens were fed the same levels of canthaxanthin to determine the rate of incorporation into eggs. Egg canthaxanthin reached a plateau after 7 d. Canthaxanthin in the hen diet at 6 mg/kg resulted in the greatest positive effect on hen performance, with little effect on the chick.
[Mh] Termos MeSH primário: Cantaxantina
Galinhas/fisiologia
Dieta/veterinária
Suplementos Nutricionais
Imunidade Inata/fisiologia
[Mh] Termos MeSH secundário: Fatores Etários
Ração Animal/análise
Animais
Antioxidantes
Galinhas/crescimento & desenvolvimento
Galinhas/imunologia
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 4C3C6403MU (Canthaxanthin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE
[do] DOI:10.3382/ps/pew293


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[PMID]:27601683
[Au] Autor:Rosa AP; Bonilla CE; Londero A; Giacomini CB; Orso C; Fernandes MO; Moura JS; Hermes R
[Ad] Endereço:Poultry Science Laboratory, Department of Animal Sciences, Federal University of Santa Maria, 97105-000 Brazil.
[Ti] Título:Effect of broiler breeders fed with corn or sorghum and canthaxanthin on lipid peroxidation, fatty acid profile of hatching eggs, and offspring performance.
[So] Source:Poult Sci;96(3):647-658, 2017 Mar 01.
[Is] ISSN:1525-3171
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of study was to evaluate the effect on broiler breeders fed with corn or sorghum diets and canthaxanthin on lipid peroxidation, fatty acid, and offspring's performance. A total of 440 females with similar body weight (BW) (3.77 ± 0.11 kg) and 60 roosters were placed in an open-sided house with 20 pens, randomly distributed in a factorial arrangement (2 × 2). There were 4 diets of 2 ingredients; corn (CO) or sorghum (SO) and 2 levels of canthaxanthin; 6 mg/kg (CX) and 0 mg/kg (NCX) totaling five replicate pens of 22 females and 3 males each, from 45 to 65 wk old. The BW was measured every 28 days, carotenoid concentration, thiobarbituric acid reactive substances (TBARS), fatty acid profile (%) in egg yolks, and the performance from two incubations and their offspring were evaluated. The study had the same statistical design as broiler breeders, making a total of 4 groups with 10 replicate pens of 8 chicks each. The BW and mortality were not affected (P > 0.05) by diets. Egg yolks coming from the CO diet had the highest (P < 0.05) lutein (3.8 vs. 0.49 mg/kg) and zeaxanthin (4.25 vs. 0.22 mg/kg) concentration compared to SO diet. The SO+CX diet had the highest CX concentration (P < 0.0001). The SO+CX diet showed the lowest TBARS (P = 0.0002) in the egg yolk compared to the CO+CX diet. Egg yolks coming from breeders fed with CO showed a higher concentration of saturated fatty acids (23.36 vs. 21.44%) and monounsaturated fatty acids (27.17 vs. 24.96%). Egg yolks arising from broiler breeders fed with SO diets showed a higher concentration of polyunsaturated fatty acids compared (15.29 vs. 12.88%). The CX reduced the offspring CO diets mortality and improved their viability at 64 wk-old for the broiler breeders (P < 0.05). CX was well absorbed from the diet and effectively transferred to the egg yolk, thereby increasing its concentration in the yolk. This conferred resistance to oxidative stress to the yolk and also later to the developing embryo and its ultimate performance.
[Mh] Termos MeSH primário: Cantaxantina
Galinhas/fisiologia
Dieta/veterinária
Suplementos Nutricionais
Ácidos Graxos/metabolismo
Peroxidação de Lipídeos/fisiologia
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Antioxidantes
Galinhas/crescimento & desenvolvimento
Feminino
Masculino
Distribuição Aleatória
Sorghum/química
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Fatty Acids); 4C3C6403MU (Canthaxanthin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE
[do] DOI:10.3382/ps/pew294


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[PMID]:27079155
[Au] Autor:Ren ZZ; Jiang SZ; Zeng QF; Ding XM; Bai SP; Wang JP; Luo YH; Su ZW; Xuan Y; Zhang KY
[Ad] Endereço:Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China.
[Ti] Título:Effect of maternal canthaxanthin and 25-hydroxycholecalciferol supplementation on the performance of ducklings under two different vitamin regimens.
[So] Source:J Anim Physiol Anim Nutr (Berl);101(2):359-368, 2017 Apr.
[Is] ISSN:1439-0396
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study investigated the effects of maternal canthaxanthin (CX, 6 mg/kg) and 25-hydroxycholecalciferol (25-OH-D , 0.069 mg/kg) supplementation on the performance of Cherry Valley ducklings under two different vitamin regimens. A total of 780 duck breeder females and 156 males were randomly allotted to two diets with or without the addition of the mixture of CX and 25-OH-D (CX+25-OH-D ) for 32 weeks. Ducklings (males and females separately) hatched from eggs laid at 24 weeks of the duck breeder trial were fed with a NRC vitamin regimen, and ducklings (males and females separately) hatched from eggs laid at 32 weeks of the duck breeder trial were fed with a HIGH vitamin regimen (had higher levels of all vitamins except biotin than NRC vitamin regimen), for 14 days. The results showed that, maternal CX+25-OH-D supplementation increased the shank pigmentation for 7-days post hatch in ducklings under a NRC vitamin regimen, and for 14-days post hatch in ducklings under a HIGH vitamin regimen. Growth performance, antioxidant status and serum phosphorus of ducklings under a NRC vitamin regimen were increased by maternal CX+25-OH-D supplementation; however, these positive effects were not observed in ducklings under a HIGH vitamin regimen. Males revealed increased growth performance in ducklings under both NRC and HIGH vitamin regimens. Sexual differences in shank pigmentation, antioxidant status, tibia strength and serum phosphorus were not consistent as they were dependent on maternal CX+25-OH-D status or dietary vitamin regimens. Data suggest that maternal CX+25-OH-D supplementation is important for starter ducklings under a NRC vitamin regimen, but not HIGH vitamin regimen.
[Mh] Termos MeSH primário: Calcifediol/farmacologia
Cantaxantina/farmacologia
Suplementos Nutricionais
Fenômenos Fisiológicos da Nutrição Materna
Vitaminas/administração & dosagem
[Mh] Termos MeSH secundário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Animais
Calcifediol/administração & dosagem
Cantaxantina/administração & dosagem
Dieta/veterinária
Patos
Feminino
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Vitamins); 4C3C6403MU (Canthaxanthin); P6YZ13C99Q (Calcifediol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.1111/jpn.12453


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[PMID]:27644134
[Au] Autor:Taweechaipaisankul A; Jin JX; Lee S; Kim GA; Lee BC
[Ad] Endereço:Department of Theriogenology and Biotechnology, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
[Ti] Título:The effects of canthaxanthin on porcine oocyte maturation and embryo development in vitro after parthenogenetic activation and somatic cell nuclear transfer.
[So] Source:Reprod Domest Anim;51(6):870-876, 2016 Dec.
[Is] ISSN:1439-0531
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to examine the effects of canthaxanthin (Cx) treatment during in vitro maturation (IVM) of porcine oocytes on embryonic development after parthenogenetic activation (PA) and somatic cell nuclear transfer (SCNT), on intracellular glutathione (GSH) and reactive oxygen species (ROS) levels in mature oocytes, and on gene expression in both PA- and SCNT-derived blastocysts. To determine the optimal effective concentration of Cx, porcine oocytes were cultured in IVM medium supplemented with various concentrations (0, 20, 40 and 80 µM) of Cx for 22 hr. Compared to other groups, supplementation with 40 µM Cx significantly improved blastocyst formation rates after PA (p < .05), but no significant differences were observed among groups in total blastocyst cell numbers. Subsequently, oocytes were cultured in IVM medium supplemented with or without 40 µM Cx. Oocytes treated with 40 µM Cx showed significantly increased cleavage and blastocyst formation rates after SCNT compared to the control group (p < .05). Moreover, significantly increased intracellular GSH and reduced ROS levels were observed in the Cx-treated group (p < .05). In addition, both PA- and SCNT-derived blastocysts from the 40 µM Cx-treated group showed significantly increased mRNA expression of Bcl2 and Oct4 and decreased Caspase3 expression level (p < .05), when compared with the control group. PA-derived blastocysts from the 40 µM Cx-treated group also exhibited significantly decreased expression of Bax (p < .05). Our results demonstrated that treatment with 40 µM Cx during IVM improves the developmental competence of PA and SCNT embryos. Improvement of embryo development by Cx is most likely due to increased intracellular GSH synthesis, which reduces ROS levels in oocytes, and it may also positively regulate apoptosis- and development-related genes.
[Mh] Termos MeSH primário: Cantaxantina/farmacologia
Técnicas de Cultura Embrionária/veterinária
Técnicas de Maturação in Vitro de Oócitos/veterinária
Técnicas de Transferência Nuclear/veterinária
Partenogênese
Suínos
[Mh] Termos MeSH secundário: Animais
Blastocisto/efeitos dos fármacos
Cantaxantina/administração & dosagem
Relação Dose-Resposta a Droga
Embrião de Mamíferos
Feminino
Regulação da Expressão Gênica no Desenvolvimento/fisiologia
Glutationa
Técnicas de Maturação in Vitro de Oócitos/métodos
Espécies Reativas de Oxigênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 4C3C6403MU (Canthaxanthin); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE
[do] DOI:10.1111/rda.12748


  10 / 357 MEDLINE  
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[PMID]:27564697
[Au] Autor:Sandmann G; Mautz J; Breitenbach J
[Ti] Título:Control of light-dependent keto carotenoid biosynthesis in Nostoc 7120 by the transcription factor NtcA.
[So] Source:Z Naturforsch C;71(9-10):303-311, 2016 Sep 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In Nostoc PCC 7120, two different ketolases, CrtW and CrtO are involved in the formation of keto carotenoids from ß-carotene. In contrast to other cyanobacteria, CrtW catalyzes the formation of monoketo echinenone whereas CrtO is the only enzyme for the synthesis of diketo canthaxanthin. This is the major photo protective carotenoid in this cyanobacterium. Under high-light conditions, basic canthaxanthin formation was transcriptionally up-regulated. Upon transfer to high light, the transcript levels of all investigated carotenogenic genes including those coding for phytoene synthase, phytoene desaturase and both ketolases were increased. These transcription changes proceeded via binding of the transcription factor NtcA to the promoter regions of the carotenogenic genes. The binding was absolutely dependent on the presence of reductants and oxo-glutarate. Light-stimulated transcript formation was inhibited by DCMU. Therefore, photosynthetic electron transport is proposed as the sensor for high-light and a changing redox state as a signal for NtcA binding.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Carotenoides/biossíntese
Luz
Nostoc/efeitos da radiação
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Sequência de Bases
Cantaxantina/biossíntese
Diurona/farmacologia
Relação Dose-Resposta à Radiação
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Regulação Bacteriana da Expressão Gênica/efeitos da radiação
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Regulação Enzimológica da Expressão Gênica/efeitos da radiação
Geranil-Geranildifosfato Geranil-Geraniltransferase/genética
Geranil-Geranildifosfato Geranil-Geraniltransferase/metabolismo
Herbicidas/farmacologia
Nostoc/genética
Nostoc/metabolismo
Oxirredutases/genética
Oxirredutases/metabolismo
Oxigenases/genética
Oxigenases/metabolismo
Regiões Promotoras Genéticas/genética
Ligação Proteica
Reação em Cadeia da Polimerase Via Transcriptase Reversa
beta Caroteno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Herbicides); 0 (Transcription Factors); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); 4C3C6403MU (Canthaxanthin); 9I3SDS92WY (Diuron); EC 1.- (Oxidoreductases); EC 1.13.- (Oxygenases); EC 1.13.- (beta-carotene ketolase); EC 1.14.99.- (phytoene dehydrogenase); EC 2.5.1.32 (Geranylgeranyl-Diphosphate Geranylgeranyltransferase); LJ5IO02MNQ (echinenone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170125
[Lr] Data última revisão:
170125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE



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