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Pesquisa : D02.455.326.271.665.202.868.374 [Categoria DeCS]
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  1 / 358 MEDLINE  
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[PMID]:28515376
[Au] Autor:Maoka T; Sato W; Nagai H; Takahashi T
[Ad] Endereço:Research Institute for Production Development.
[Ti] Título:Carotenoids of Red, Brown, and Black Specimens of Plectropomus leopardus, the Coral Trout (Suziara in Japanese).
[So] Source:J Oleo Sci;66(6):579-584, 2017 Jun 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study investigated the carotenoids occurring in the integument of Plectropomus leopardus, the coral trout. For a red specimen, the major carotenoids included astaxanthin diester and monoester, as well as α-cryptoxanthin ester, tunaxanthin diester, adonixanthin diester, adonirubin ester, and adonirubin; for brown and black specimens, tunaxanthin diester was the main carotenoid. H-NMR and MS spectral analyses showed that docosahexaenoic acid was the sole fatty acid esterified with xanthophylls in the coral trout.
[Mh] Termos MeSH primário: Cor
Peixes/metabolismo
Xantofilas/análise
[Mh] Termos MeSH secundário: Animais
Cantaxantina/análogos & derivados
Carotenoides
Criptoxantinas
Ácidos Docosa-Hexaenoicos
Esterificação
Ésteres
Xantofilas/química
Xantofilas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Esters); 0 (Xanthophylls); 0 (adonirubin); 0 (adonixanthin); 25167-62-8 (Docosahexaenoic Acids); 36-88-4 (Carotenoids); 4C3C6403MU (Canthaxanthin); 8XPW32PR7I (astaxanthine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16179


  2 / 358 MEDLINE  
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[PMID]:28420094
[Au] Autor:Kitade H; Chen G; Ni Y; Ota T
[Ad] Endereço:Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. hiro.kitacchi@gmail.com.
[Ti] Título:Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments.
[So] Source:Nutrients;9(4), 2017 Apr 14.
[Is] ISSN:2072-6643
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma. Metabolic disorders, such as lipid accumulation, insulin resistance, and inflammation, have been implicated in the pathogenesis of NAFLD, but the underlying mechanisms, including those that drive disease progression, are not fully understood. Both innate and recruited immune cells mediate the development of insulin resistance and NASH. Therefore, modifying the polarization of resident and recruited macrophage/Kupffer cells is expected to lead to new therapeutic strategies in NAFLD. Oxidative stress is also pivotal for the progression of NASH, which has generated interest in carotenoids as potent micronutrient antioxidants in the treatment of NAFLD. In addition to their antioxidative function, carotenoids regulate macrophage/Kupffer cell polarization and thereby prevent NASH progression. In this review, we summarize the molecular mechanisms involved in the pathogenesis of NAFLD, including macrophage/Kupffer cell polarization, and disturbed hepatic function in NAFLD. We also discuss dietary antioxidants, such as ß-cryptoxanthin and astaxanthin, that may be effective in the prevention or treatment of NAFLD.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Carotenoides/uso terapêutico
Resistência à Insulina
Fígado/patologia
Macrófagos
Hepatopatia Gordurosa não Alcoólica/terapia
Estresse Oxidativo
[Mh] Termos MeSH secundário: Criptoxantinas/uso terapêutico
Seres Humanos
Resistência à Insulina/imunologia
Fígado/imunologia
Fígado/metabolismo
Hepatopatia Gordurosa não Alcoólica/etiologia
Hepatopatia Gordurosa não Alcoólica/imunologia
Hepatopatia Gordurosa não Alcoólica/metabolismo
Xantofilas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cryptoxanthins); 0 (Xanthophylls); 36-88-4 (Carotenoids); 8XPW32PR7I (astaxanthine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170420
[St] Status:MEDLINE


  3 / 358 MEDLINE  
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[PMID]:28041601
[Au] Autor:Hirose A; Terauchi M; Hirano M; Akiyoshi M; Owa Y; Kato K; Kubota T
[Ad] Endereço:Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan; Department of Women's Health, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan. Electronic address: a-kacrm@tmd.ac.jp.
[Ti] Título:Higher intake of cryptoxanthin is related to low body mass index and body fat in Japanese middle-aged women.
[So] Source:Maturitas;96:89-94, 2017 Feb.
[Is] ISSN:1873-4111
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The prevalence of cardiovascular diseases increases with age, especially in postmenopausal women. In this study, we investigated the dietary patterns associated with body mass and body fat in Japanese middle-aged women. STUDY DESIGN: Cross-sectional. MAIN OUTCOME MEASURES: This study used baseline data collected in a previous study in 88 women aged 40-60 years. Participants were assessed for age, menopausal status, lifestyle factors, body composition, and dietary habits using a brief-type self-administered diet history questionnaire, which provides information on the amounts of nearly 100 nutritional factors consumed during the previous month. Classifying body mass index (BMI) as low (≤22kg/m ) or high (>22kg/m ) and percentage body fat as low (≤25%) or high (>25%), we sought to identify the nutritional factors associated with BMI and percentage body fat. RESULTS: Consumption differences between high/low BMI and high/low body fat percentage groups were not significant for any nutritional factors except cryptoxanthin. Multiple logistic regression analysis adjusting for age, menopausal status, working, exercise, and smoking revealed that higher cryptoxanthin intake was associated with low BMI (adjusted odds ratio, 1.22 per 100µg/day increase of cryptoxanthin intake; 95% confidence interval, 1.01-1.52) and low body fat percentage (adjusted odds ratio, 1.36 per 100µg/day increase of cryptoxanthin intake; 95% confidence interval, 1.13-1.70). CONCLUSIONS: Higher intake of cryptoxanthin was shown to be related to low body mass and body fat in Japanese middle-aged women.
[Mh] Termos MeSH primário: Adiposidade
Índice de Massa Corporal
Criptoxantinas
Dieta
[Mh] Termos MeSH secundário: Adulto
Composição Corporal
Estudos Transversais
Comportamento Alimentar
Feminino
Seres Humanos
Japão
Meia-Idade
Inquéritos e Questionários
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryptoxanthins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


  4 / 358 MEDLINE  
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[PMID]:27598884
[Au] Autor:Murillo E; Turcsi E; Szabó I; Mosquera Y; Agócs A; Nagy V; Gulyás-Fekete G; Deli J
[Ad] Endereço:Department of Biochemistry, Faculty of Exact Natural Sciences and Technology, University of Panamá , 074637 Panamá City, Panamá
[Ti] Título:Carotenoid Composition of the Fruit of Red Mamey (Pouteria sapota).
[So] Source:J Agric Food Chem;64(38):7148-55, 2016 Sep 28.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The detailed carotenoid analysis of red mamey (Pouteria sapota) was achieved by HPLC-DAD-MS, chemical tests, and cochromatography with authentic samples. Altogether 47 components were detected and 34 identified from the total extract or after fractionation with column chromatography. The main carotenoids were cryptocapsin, sapotexanthin, and capsanthin 5,6-epoxide. Some further minor components containing the κ-end group with or without a hydroxy group and their 5,6-epoxy precursors were identified. Some comments are made about the biosynthesis of κ-carotenoids in red mamey.
[Mh] Termos MeSH primário: Carotenoides/análise
Frutas/química
Pouteria/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Criptoxantinas/análise
Espectrometria de Massas
Pigmentos Biológicos/química
Xantofilas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Pigments, Biological); 0 (Xanthophylls); 0 (sapotexanthin); 36-88-4 (Carotenoids); 420NY1J57N (capsanthin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170426
[Lr] Data última revisão:
170426
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b03146


  5 / 358 MEDLINE  
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[PMID]:27485231
[Au] Autor:Bonet ML; Canas JA; Ribot J; Palou A
[Ad] Endereço:Group of Nutrigenomics and Obesity, Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears, Cra. Valldemossa Km 7.5. 07122, Palma de Mallorca, Spain. luisabonet@uib.es.
[Ti] Título:Carotenoids in Adipose Tissue Biology and Obesity.
[So] Source:Subcell Biochem;79:377-414, 2016.
[Is] ISSN:0306-0225
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cell, animal and human studies dealing with carotenoids and carotenoid derivatives as nutritional regulators of adipose tissue biology with implications for the etiology and management of obesity and obesity-related metabolic diseases are reviewed. Most studied carotenoids in this context are ß-carotene, cryptoxanthin, astaxanthin and fucoxanthin, together with ß-carotene-derived retinoids and some other apocarotenoids. Studies indicate an impact of these compounds on essential aspects of adipose tissue biology including the control of adipocyte differentiation (adipogenesis), adipocyte metabolism, oxidative stress and the production of adipose tissue-derived regulatory signals and inflammatory mediators. Specific carotenoids and carotenoid derivatives restrain adipogenesis and adipocyte hypertrophy while enhancing fat oxidation and energy dissipation in brown and white adipocytes, and counteract obesity in animal models. Intake, blood levels and adipocyte content of carotenoids are reduced in human obesity. Specifically designed human intervention studies in the field, though still sparse, indicate a beneficial effect of carotenoid supplementation in the accrual of abdominal adiposity. In summary, studies support a role of specific carotenoids and carotenoid derivatives in the prevention of excess adiposity, and suggest that carotenoid requirements may be dependent on body composition.
[Mh] Termos MeSH primário: Tecido Adiposo/metabolismo
Carotenoides/metabolismo
Obesidade/metabolismo
beta Caroteno/metabolismo
[Mh] Termos MeSH secundário: Adipócitos/metabolismo
Tecido Adiposo/patologia
Animais
Carotenoides/uso terapêutico
Criptoxantinas/metabolismo
Seres Humanos
Obesidade/dietoterapia
Obesidade/patologia
Xantofilas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Xanthophylls); 01YAE03M7J (beta Carotene); 06O0TC0VSM (fucoxanthin); 36-88-4 (Carotenoids); 8XPW32PR7I (astaxanthine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160804
[St] Status:MEDLINE
[do] DOI:10.1007/978-3-319-39126-7_15


  6 / 358 MEDLINE  
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[PMID]:27143479
[Au] Autor:Dela Seña C; Sun J; Narayanasamy S; Riedl KM; Yuan Y; Curley RW; Schwartz SJ; Harrison EH
[Ad] Endereço:From the Department of Human Nutrition, Ohio State Biochemistry Program.
[Ti] Título:Substrate Specificity of Purified Recombinant Chicken ß-Carotene 9',10'-Oxygenase (BCO2).
[So] Source:J Biol Chem;291(28):14609-19, 2016 Jul 08.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Provitamin A carotenoids are oxidatively cleaved by ß-carotene 15,15'-dioxygenase (BCO1) at the central 15-15' double bond to form retinal (vitamin A aldehyde). Another carotenoid oxygenase, ß-carotene 9',10'-oxygenase (BCO2) catalyzes the oxidative cleavage of carotenoids at the 9'-10' bond to yield an ionone and an apo-10'-carotenoid. Previously published substrate specificity studies of BCO2 were conducted using crude lysates from bacteria or insect cells expressing recombinant BCO2. Our attempts to obtain active recombinant human BCO2 expressed in Escherichia coli were unsuccessful. We have expressed recombinant chicken BCO2 in the strain E. coli BL21-Gold (DE3) and purified the enzyme by cobalt ion affinity chromatography. Like BCO1, purified recombinant chicken BCO2 catalyzes the oxidative cleavage of the provitamin A carotenoids ß-carotene, α-carotene, and ß-cryptoxanthin. Its catalytic activity with ß-carotene as substrate is at least 10-fold lower than that of BCO1. In further contrast to BCO1, purified recombinant chicken BCO2 also catalyzes the oxidative cleavage of 9-cis-ß-carotene and the non-provitamin A carotenoids zeaxanthin and lutein, and is inactive with all-trans-lycopene and ß-apocarotenoids. Apo-10'-carotenoids were detected as enzymatic products by HPLC, and the identities were confirmed by LC-MS. Small amounts of 3-hydroxy-ß-apo-8'-carotenal were also consistently detected in BCO2-ß-cryptoxanthin reaction mixtures. With the exception of this activity with ß-cryptoxanthin, BCO2 cleaves specifically at the 9'-10' bond to produce apo-10'-carotenoids. BCO2 has been shown to function in preventing the excessive accumulation of carotenoids, and its broad substrate specificity is consistent with this.
[Mh] Termos MeSH primário: Galinhas/metabolismo
Dioxigenases/metabolismo
beta Caroteno/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Carotenoides/química
Carotenoides/metabolismo
Galinhas/genética
Criptoxantinas/química
Criptoxantinas/metabolismo
Dioxigenases/química
Dioxigenases/genética
Seres Humanos
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Alinhamento de Sequência
Especificidade por Substrato
beta Caroteno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Recombinant Proteins); 0 (beta-apo-8'-carotenal); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); 45XWE1Z69V (alpha-carotene); EC 1.13.11.- (Dioxygenases); EC 1.14.99.- (BCO2 protein, human)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160505
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.723684


  7 / 358 MEDLINE  
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[PMID]:27132842
[Au] Autor:Zaghdoudi K; Framboisier X; Frochot C; Vanderesse R; Barth D; Kalthoum-Cherif J; Blanchard F; Guiavarc'h Y
[Ad] Endereço:Laboratoire Réactions et Génie des Procédés (LRGP), UMR 7274, CNRS-Université de Lorraine, ENSIC, 1 rue Grandville, 54001 Nancy, France; Laboratoire de Chimie Physique Macromoléculaire (LCPM), UMR 7375, CNRS-Université de Lorraine, ENSIC, 1 rue Grandville, 54001 Nancy, France; Laboratoire d'Applicat
[Ti] Título:Response surface methodology applied to Supercritical Fluid Extraction (SFE) of carotenoids from Persimmon (Diospyros kaki L.).
[So] Source:Food Chem;208:209-19, 2016 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Supercritical carbon dioxide with ethanol as co-solvent was used to extract carotenoids from persimmon fruits (Diospyros kaki L.). Based on a response surface methodology (RSM), a predicting model describing the effects of CO2 temperature, pressure, flow rate, ethanol percentage and extraction time was set up for each of the four carotenoids of interest. The best extraction yields in our experimental domain were found at 300 bars, 60°C, 25% (w/w) ethanol, 3mL/min flow rate and 30min for xanthophylls (all-trans-lutein, all-trans-zeaxanthin and all-trans-ß-cryptoxanthin). The yields were 15.46±0.56, 16.81±1.74 and 33.23±2.91µg/g of persimmon powder for all-trans-lutein, all-trans-zeaxanthin and all-trans-ß-cryptoxanthin, respectively. As a non-oxygenated carotenoid, all-trans-ß-carotene was better extracted using 100 bars, 40°C, 25% (w/w) ethanol, 1mL/min flow rate and 30min extraction time, with an extraction yield of 11.19±0.47µg/g of persimmon powder.
[Mh] Termos MeSH primário: Carotenoides/análise
Cromatografia com Fluido Supercrítico/métodos
Diospyros/química
Frutas/química
[Mh] Termos MeSH secundário: Criptoxantinas/análise
Etanol/química
Limite de Detecção
Luteína/análise
Temperatura Ambiente
Xantofilas/análise
Zeaxantinas/análise
beta Caroteno/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Xanthophylls); 0 (Zeaxanthins); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); 3K9958V90M (Ethanol); X72A60C9MT (Lutein)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170206
[Lr] Data última revisão:
170206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE


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[PMID]:26747887
[Au] Autor:Burri BJ; La Frano MR; Zhu C
[Ad] Endereço:B.J. Burri, M.R. La Frano, and C. Zhu are with the Western Human Nutrition Research Center, US Department of Agriculture/Agricultural Research Service, Department of Nutrition, University of California, Davis, California, USA. bburri@pacbell.net.
[Ti] Título:Absorption, metabolism, and functions of ß-cryptoxanthin.
[So] Source:Nutr Rev;74(2):69-82, 2016 Feb.
[Is] ISSN:1753-4887
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:ß-Cryptoxanthin, a carotenoid found in fruits and vegetables such as tangerines, red peppers, and pumpkin, has several functions important for human health. Most evidence from observational, in vitro, animal model, and human studies suggests that ß-cryptoxanthin has relatively high bioavailability from its common food sources, to the extent that some ß-cryptoxanthin-rich foods might be equivalent to ß-carotene-rich foods as sources of retinol. ß-Cryptoxanthin is an antioxidant in vitro and appears to be associated with decreased risk of some cancers and degenerative diseases. In addition, many in vitro, animal model, and human studies suggest that ß-cryptoxanthin-rich foods may have an anabolic effect on bone and, thus, may help delay osteoporosis.
[Mh] Termos MeSH primário: Antioxidantes
Osso e Ossos/efeitos dos fármacos
Criptoxantinas
Dieta
Neoplasias/prevenção & controle
Vitamina A/metabolismo
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Disponibilidade Biológica
Carotenoides
Criptoxantinas/metabolismo
Criptoxantinas/farmacologia
Criptoxantinas/uso terapêutico
Seres Humanos
Absorção Intestinal
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cryptoxanthins); 11103-57-4 (Vitamin A); 36-88-4 (Carotenoids)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160110
[St] Status:MEDLINE
[do] DOI:10.1093/nutrit/nuv064


  9 / 358 MEDLINE  
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[PMID]:26468119
[Au] Autor:Emmett SD; West KP
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; and Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
[Ti] Título:Nutrition and hearing loss: a neglected cause and global health burden.
[So] Source:Am J Clin Nutr;102(5):987-8, 2015 Nov.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anemia Ferropriva/fisiopatologia
Ácido Ascórbico/efeitos adversos
Doenças Auditivas Centrais/etiologia
Vias Auditivas/fisiopatologia
Criptoxantinas/uso terapêutico
Dieta/efeitos adversos
Ácido Fólico/uso terapêutico
Perda Auditiva/epidemiologia
Doenças do Prematuro/fisiopatologia
Fenômenos Fisiológicos da Nutrição Materna
Neurogênese
Complicações na Gravidez/fisiopatologia
beta Caroteno/uso terapêutico
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
Gravidez
[Pt] Tipo de publicação:COMMENT; LETTER; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cryptoxanthins); 01YAE03M7J (beta Carotene); 935E97BOY8 (Folic Acid); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:151016
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.115.122598


  10 / 358 MEDLINE  
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[PMID]:26365147
[Au] Autor:Sugiura M; Nakamura M; Ogawa K; Ikoma Y; Yano M
[Ad] Endereço:1Citrus Research Division,NARO Institute of Fruit Tree Science,National Agriculture and Food Research Organization,485-6 Okitsu-nakachou,Shimizu,Shizuoka City,Shizuoka 424-0292,Japan.
[Ti] Título:High serum carotenoids associated with lower risk for the metabolic syndrome and its components among Japanese subjects: Mikkabi cohort study.
[So] Source:Br J Nutr;114(10):1674-82, 2015 Nov 28.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Recent epidemiological studies show the association of carotenoids with the metabolic syndrome (MetS), but thorough longitudinal cohort studies regarding this association have not been well conducted. The objective of this study was to investigate longitudinally whether serum carotenoids are associated with the risk of developing the MetS and its components in Japanese subjects. We conducted a follow-up study on 1073 men and women aged 30-79 years at the baseline from the Mikkabi prospective cohort study. Those who participated in the baseline and completed follow-up surveys were examined longitudinally. Over the 10-year period, 910 subjects (295 men and 615 women) took part in the follow-up survey at least once. Over a mean follow-up period of 7·8 (sd 2·9) years, thirty-six men and thirty-one women developed new MetS. After adjustments for confounders, the hazard ratio (HR) for the MetS in the highest tertile of serum ß-carotene against the lowest tertile was 0·47 (95 % CI 0·23, 0·95). On the other hand, significantly lower risks for dyslipidaemia were observed in the highest tertiles of serum α- and ß-carotene and ß-cryptoxanthin (HR 0·66; 95 % CI 0·46, 0·96; HR, 0·54; 95 % CI 0·37, 0·79; and HR 0·66; 95 % CI 0·44, 0·99, respectively). Other significant associations between the risks for obesity, high blood pressure and hyperglycaemia with serum carotenoids were not observed. Our results further support the hypothesis that eating a diet rich in carotenoids might help prevent the development of the MetS and its complications in Japanese subjects.
[Mh] Termos MeSH primário: Carotenoides/sangue
Síndrome Metabólica/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Estudos de Coortes
Criptoxantinas/sangue
Feminino
Seguimentos
Seres Humanos
Japão/epidemiologia
Estudos Longitudinais
Luteína/sangue
Masculino
Síndrome Metabólica/epidemiologia
Meia-Idade
Estudos Prospectivos
Fatores de Risco
Zeaxantinas/sangue
beta Caroteno/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cryptoxanthins); 0 (Zeaxanthins); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); 45XWE1Z69V (alpha-carotene); SB0N2N0WV6 (lycopene); X72A60C9MT (Lutein)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150915
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114515003268



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