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  1 / 1956 MEDLINE  
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[PMID]:27776568
[Au] Autor:Lindbergh CA; Mewborn CM; Hammond BR; Renzi-Hammond LM; Curran-Celentano JM; Miller LS
[Ad] Endereço:1Department of Psychology,University of Georgia,Athens,Georgia.
[Ti] Título:Relationship of Lutein and Zeaxanthin Levels to Neurocognitive Functioning: An fMRI Study of Older Adults.
[So] Source:J Int Neuropsychol Soc;23(1):11-22, 2017 Jan.
[Is] ISSN:1469-7661
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: It is well known that the carotenoids lutein (L) and zeaxanthin (Z) improve eye health and an accumulating evidence base suggests cognitive benefits as well. The present study investigated underlying neural mechanisms using functional magnetic resonance imaging (fMRI). It was hypothesized that lower L and Z concentrations would be associated with neurobiological inefficiency (i.e., increased activation) during cognitive performance. METHODS: Forty-three community-dwelling older adults (mean age=72 years; 58% female; 100% Caucasian) were asked to learn and recall pairs of unrelated words in an fMRI-adapted paradigm. L and Z levels were measured in retina (macular pigment optical density) and serum using validated procedures. RESULTS: Following first-level contrasts of encoding and retrieval trials minus control trials (p<.05, family-wise error corrected, minimum voxel cluster=8), L and Z were found to significantly and negatively relate to blood-oxygen-level-dependent signal in central and parietal operculum cortex, inferior frontal gyrus, supramarginal gyrus, planum polare, frontal and middle temporal gyrus, superior parietal lobule, postcentral gyrus, precentral gyrus, occipital cortex bilaterally, and cerebellar regions. CONCLUSIONS: To the authors' knowledge, the present study represents the first attempt to investigate neural mechanisms underlying the relation of L and Z to cognition using fMRI. The observed results suggest that L and Z promote cognitive functioning in old age by enhancing neural efficiency. (JINS, 2017, 23, 11-22).
[Mh] Termos MeSH primário: Envelhecimento/sangue
Encéfalo/diagnóstico por imagem
Envelhecimento Cognitivo
Luteína/sangue
Imagem por Ressonância Magnética
Zeaxantinas/sangue
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Envelhecimento/patologia
Mapeamento Encefálico
Depressão/sangue
Depressão/diagnóstico por imagem
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Vida Independente
Pigmento Macular/metabolismo
Masculino
Testes Neuropsicológicos
Oxigênio/sangue
Leitura
Aprendizagem Verbal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Macular Pigment); 0 (Zeaxanthins); S88TT14065 (Oxygen); X72A60C9MT (Lutein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1017/S1355617716000850


  2 / 1956 MEDLINE  
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[PMID]:29319312
[Au] Autor:Huang W; Lin Y; He M; Gong Y; Huang J
[Ad] Endereço:Department of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, China.
[Ti] Título:Induced High-Yield Production of Zeaxanthin, Lutein, and ß-Carotene by a Mutant of Chlorella zofingiensis.
[So] Source:J Agric Food Chem;66(4):891-897, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural resources of zeaxanthin are extremely limited. A Chlorella zofingiensis mutant (CZ-bkt1), which could accumulate high amounts of zeaxanthin, was generated and characterized. CZ-bkt1 was achieved by treating the algal cells with a chemical mutagen followed by a color-based colony-screening approach. CZ-bkt1 was found to consist of a dysfunctional carotenoid ketolase, leading to the accumulation of zeaxanthin rather than to its downstream ketocarotenoid astaxanthin. Light irradiation, glucose, NaCl, and nitrogen deficiency all induced CZ-bkt1 to accumulate zeaxanthin. CZ-bkt1 accumulated zeaxanthin up to 7.00 ± 0.82 mg/g when induced by high-light irradiation and nitrogen deficiency and up to 36.79 ± 2.23 mg/L by additional feeding with glucose. Furthermore, in addition to zeaxanthin, CZ-bkt1 also accumulated high amounts of ß-carotene (7.18 ± 0.72 mg/g or 34.64 ± 1.39 mg/L) and lutein (13.81 ± 1.23 mg/g or 33.97 ± 2.61 mg/L). CZ-bkt1 is the sole species up to date with the ability to accumulate high amounts of the three carotenoids that are essential for human health.
[Mh] Termos MeSH primário: Chlorella/genética
Chlorella/metabolismo
Luteína/biossíntese
Zeaxantinas/biossíntese
beta Caroteno/biossíntese
[Mh] Termos MeSH secundário: Carotenoides/metabolismo
Códon sem Sentido
Mutagênese
Mutação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Codon, Nonsense); 0 (Zeaxanthins); 01YAE03M7J (beta Carotene); 36-88-4 (Carotenoids); X72A60C9MT (Lutein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05400


  3 / 1956 MEDLINE  
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[PMID]:28458359
[Au] Autor:Takeda H; Tominari T; Hirata M; Watanabe K; Matsumoto C; Grundler FMW; Inada M; Miyaura C
[Ad] Endereço:Cooperative Major of Advanced Health Science, Tokyo University of Agriculture and Technology.
[Ti] Título:Lutein Enhances Bone Mass by Stimulating Bone Formation and Suppressing Bone Resorption in Growing Mice.
[So] Source:Biol Pharm Bull;40(5):716-721, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Lutein is a member of the xanthophyll family of carotenoids, which are known to prevent hypoxia-induced cell damage in the eye by removing free radicals. However, its role in other tissues is controversial, and the effects of lutein on bone tissues are unknown. To identify a possible role of lutein in bone tissues, we examined the effects of lutein on bone formation and bone resorption and on femoral bone mass in mice. Lutein enhanced the formation of mineralized bone nodules in cultures of osteoblasts. On the other hand, lutein clearly suppressed 1α, 25-dihydroxyvitamin D -induced bone resorption as measured by pit formation in organ culture of mouse calvaria. In co-cultures of bone marrow cells and osteoblasts, lutein suppressed 1α, 25-dihydroxyvitamin D -induced osteoclast formation. In cultures of bone marrow macrophages, lutein suppressed soluble RANKL, the receptor activator of nuclear factor-kappaB (NF-κB) ligand, induced osteoclast formation. When five-week-old male mice were orally administered lutein for 4 weeks, the femoral bone mass was clearly enhanced in cortical bone, as measured by bone mineral density in dual X-ray absorptiometry and micro computed tomography (µCT) analyses. The present study indicates that lutein enhances bone mass in growing mice by suppressing bone resorption and stimulating bone formation. Lutein may be a natural agent that promotes bone turnover and may be beneficial for bone health in humans.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo/efeitos dos fármacos
Reabsorção Óssea/prevenção & controle
Osso e Ossos/anatomia & histologia
Luteína/farmacologia
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Animais
Densidade Óssea/efeitos dos fármacos
Osso e Ossos/diagnóstico por imagem
Calcificação Fisiológica/efeitos dos fármacos
Calcitriol/antagonistas & inibidores
Calcitriol/farmacologia
Células Cultivadas
Fêmur/anatomia & histologia
Fêmur/efeitos dos fármacos
Luteína/uso terapêutico
Masculino
Camundongos
NF-kappa B/antagonistas & inibidores
Osteoblastos/efeitos dos fármacos
Ligante RANK/antagonistas & inibidores
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); 0 (RANK Ligand); 0 (Tnfsf11 protein, mouse); FXC9231JVH (Calcitriol); X72A60C9MT (Lutein)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00897


  4 / 1956 MEDLINE  
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[PMID]:28458419
[Au] Autor:Vasudeva V; Tenkanidiyoor YS; Radhakrishna V; Shivappa P; Lakshman SP; Fernandes R; Patali KA
[Ad] Endereço:Research Scholar, Central Research Laboratory, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka, India.
[Ti] Título:Palliative effects of lutein intervention in gamma-radiation-induced cellular damages in Swiss albino mice.
[So] Source:Indian J Pharmacol;49(1):26-33, 2017 Jan-Feb.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Radiation-induced hematological, biochemical, and cytogenetic damages to the normal cells are major concerns in the field of radiotherapy. The carotenoids and their derivatives have been the source of antioxidants with wide range of medicinal applications. The objective is to evaluate the protective effects of lutein, a carotenoid, against radiation-induced cellular and tissue damages. METHODS: Swiss albino mice were grouped into 5, 50, 250, and 500 mg/kg b.wt. of lutein treatment groups, a sham and vehicle control group. The groups were irradiated with a lethal dose of 10 Gy y'-radiation. The mortality was recorded for 30 days to optimize the protective dose against radiation. The mice were administered with the compound orally for 15 consecutive days and irradiated with a sublethal dose of 6Gy. The hematological changes in blood and antioxidant parameters were determined in liver, kidney homogenates, and hemolysate/serum. The hematological parameters were recorded using an automated cell counter. The antioxidants such as malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase were spectrophotometrically determined. RESULTS: The red blood cell, white blood cell count, lymphocyte count, hemoglobin, platelet levels, and hematocrit value were found to be decreased in the irradiated groups. Lutein pretreatment maintains near-normal levels of these parameters indicating resistance/recovery from the radiation-induced damages. The antioxidant levels were found to be reduced in all the irradiated groups. However, lutein pretreatment (50 mg/kg b.wt.) has increased the catalase activity of hemolysate. Lutein pretreatment has reduced the MDA levels in hemolysate, when administered at doses of 5, 250, and 500 mg/kg b.wt. in comparison to its control. CONCLUSION: The study demonstrates the radioprotective potential of lutein by maintaining the hematological and antioxidant homeostasis.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Luteína/farmacologia
Lesões por Radiação/prevenção & controle
Protetores contra Radiação/farmacologia
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Raios gama
Glutationa/metabolismo
Rim/efeitos dos fármacos
Rim/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Luteína/administração & dosagem
Malondialdeído/metabolismo
Camundongos
Protetores contra Radiação/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Radiation-Protective Agents); 4Y8F71G49Q (Malondialdehyde); GAN16C9B8O (Glutathione); X72A60C9MT (Lutein)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.201013


  5 / 1956 MEDLINE  
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[PMID]:28468699
[Au] Autor:Hostetler GL
[Ad] Endereço:Perrigo Nutritionals, Analytical Research and Development, 147 Industrial Park Rd, Georgia, VT 05468.
[Ti] Título:Determination of Lutein and ß-Carotene in Infant Formula and Adult Nutritionals by Ultra-High-Performance Liquid Chromatography: Single-Laboratory Validation, First Action 2016.13.
[So] Source:J AOAC Int;100(3):768-781, 2017 May 01.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An ultra-HPLC method for the determination of lutein and ß-carotene in infant formula and adult nutritionals was validated using both unfortified and fortified samples provided by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN). All experiments showed separation of all-trans-lutein and ß-carotene from their major cis isomers, apocarotenal, α-carotene, lycopene, and zeaxanthin. Samples spiked with all-trans-lutein and ß-carotene showed no isomerization during sample preparation. Linearity of the calibration solutions correlated to approximately 0.8-45 µg/100 g (reconstituted basis) for samples prepared for the lowest sample concentrations. With dilutions specified in the method, the range can be extended to approximately 2250 µg/100 g. The LOD for both lutein and ß-carotene was 0.08 µg/100 g, and the LOQ for both was 0.27 µg/100 g. For all measurements in the range of 1-100 µg/100 g, repeatability RSD was ≤5.8% for lutein and ≤5.1% for ß-carotene. For measurements >100 µg/100 g, repeatability RSD was ≤1.1% for lutein and ≤1.7% for ß-carotene. Accuracy was determined by recovery from spiked samples and ranged from 92.3 to 105.5% for lutein and from 100.1 to 107.5% for ß-carotene. The data provided show that the method meets the criteria specified in the Standard Method Performance Requirements for carotenoids (SMPR 2014.014).
[Mh] Termos MeSH primário: Alimentos Formulados/análise
Fórmulas Infantis/análise
Luteína/análise
beta Caroteno/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
01YAE03M7J (beta Carotene); X72A60C9MT (Lutein)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.16-0386


  6 / 1956 MEDLINE  
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[PMID]:28454979
[Au] Autor:Panova IG; Yakovleva MA; Tatikolov AS; Kononikhin AS; Feldman TB; Poltavtseva RA; Nikolaev EN; Sukhikh GT; Ostrovsky MA
[Ad] Endereço:Koltsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow 119334, Russia. Electronic address: pinag@mail.ru.
[Ti] Título:Lutein and its oxidized forms in eye structures throughout prenatal human development.
[So] Source:Exp Eye Res;160:31-37, 2017 07.
[Is] ISSN:1096-0007
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The presence of carotenoids in the vitreous body, retina, lens, retinal pigment epithelium together with choroid (hereinafter RPE), and ciliary body and iris together with choroidal stroma (hereinafter CBI) was studied throughout the second trimester of prenatal development of the human eye. It has been found that the vitreous body, retina, and RPE contain lutein and its oxidized forms. Zeaxanthin was not found in the tissues studied. The presence of lutein in the vitreous body is transient and no longer detected after 28 weeks of gestation. Lutein was not detected in the lens and CBI, but its oxidized forms were found. The presence of carotenoids in different tissues of the eye in the course of normal eye development and the antioxidant role of carotenoids are discussed.
[Mh] Termos MeSH primário: Corioide/metabolismo
Cristalino/metabolismo
Luteína/metabolismo
Retina/metabolismo
Epitélio Pigmentado da Retina/metabolismo
Corpo Vítreo/metabolismo
Xantofilas/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Corioide/embriologia
Feto/metabolismo
Seres Humanos
Cristalino/embriologia
Espectrometria de Massas
Meia-Idade
Oxirredução
Retina/embriologia
Epitélio Pigmentado da Retina/embriologia
Corpo Vítreo/embriologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Xanthophylls); X72A60C9MT (Lutein)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171211
[Lr] Data última revisão:
171211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  7 / 1956 MEDLINE  
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[PMID]:28873631
[Au] Autor:Li X; Wang X; Xu D; Cao Y; Wang S; Wang B; Sun B; Yuan F; Gao Y
[Ad] Endereço:Beijing Advanced Innovation Center for Food Nutrition and Human Health (BTBU), School of Food & Chemical Engineering, Beijing Engineering and Technology Research Center of Food Additives, Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients, Beijing Key Labora
[Ti] Título:Enhancing physicochemical properties of emulsions by heteroaggregation of oppositely charged lactoferrin coated lutein droplets and whey protein isolate coated DHA droplets.
[So] Source:Food Chem;239:75-85, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The formation and physicochemical stability of mixed functional components (lutein & DHA) emulsions through heteroaggregation were studied. It was formed by controlled heteroaggregation of oppositely charged lutein and DHA droplets coated by cationic lactoferrin (LF) and anionic whey protein isolate (WPI), respectively. Heteroaggregation was induced by mixing the oppositely charged LF-lutein and WPI-DHA emulsions together at pH 6.0. Droplet size, zeta-potential, transmission-physical stability, microrheological behavior and microstructure of the heteroaggregates formed were measured as a function of LF-lutein to WPI-DHA droplet ratio. Lutein degradation and DHA oxidation by measurement of lipid hydroperoxides and thiobarbituric acid reactive substances were determined. Upon mixing the two types of bioactive compounds droplets together, it was found that the largest aggregates and highest physical stability occurred at a droplet ratio of 40% LF-lutein droplets to 60% WPI-DHA droplets. Heteroaggregates formation altered the microrheological properties of the mixed emulsions mainly by the special network structure of the droplets. When LF-coated lutein droplets ratios were more than 30% and less than 60%, the mixed emulsions exhibited distinct decreases in the Mean Square Displacement, which indicated that their limited scope of Brownian motion and stable structure. Mixed emulsions with LF-lutein/WPI-DHA droplets ratio of 4:6 exhibited Macroscopic Viscosity Index with 13 times and Elasticity Index with 3 times of magnitudes higher than the individual emulsions from which they were prepared. Compared with the WPI-DHA emulsion or LF-lutein emulsion, the oxidative stability of the heteroaggregate of LF-lutein/WPI-DHA emulsions was improved. Heteroaggregates formed by oppositely charged bioactive compounds droplets may be useful for creating specific food structures that lead to desirable physicochemical properties, such as microrheological property, physical and chemical stabilities.
[Mh] Termos MeSH primário: Proteínas do Soro do Leite
[Mh] Termos MeSH secundário: Fenômenos Químicos
Emulsões
Concentração de Íons de Hidrogênio
Lactoferrina
Luteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Whey Proteins); EC 3.4.21.- (Lactoferrin); X72A60C9MT (Lutein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  8 / 1956 MEDLINE  
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[PMID]:28873580
[Au] Autor:Xiao YD; Huang WY; Li DJ; Song JF; Liu CQ; Wei QY; Zhang M; Yang QM
[Ad] Endereço:Institute of Farm Product Processing, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu 210014, China. Electronic address: xyd15838746910@163.com.
[Ti] Título:Thermal degradation kinetics of all-trans and cis-carotenoids in a light-induced model system.
[So] Source:Food Chem;239:360-368, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Thermal degradation kinetics of lutein, zeaxanthin, ß-cryptoxanthin, ß-carotene was studied at 25, 35, and 45°C in a model system. Qualitative and quantitative analyses of all-trans- and cis-carotenoids were conducted using HPLC-DAD-MS technologies. Kinetic and thermodynamic parameters were calculated by non-linear regression. A total of 29 geometrical isomers and four oxidation products were detected, including all-trans-, keto compounds, mono-cis- and di-cis-isomers. Degradations of all-trans-lutein, zeaxanthin, ß-cryptoxanthin, and ß-carotene were described by a first-order kinetic model, with the order of rate constants as k >k >k >k . Activation energies of zeaxanthin, lutein, ß-cryptoxanthin, and ß-carotene were 65.6, 38.9, 33.9, and 8.6kJ/moL, respectively. cis-carotenoids also followed with the first-order kinetic model, but they did not show a defined sequence of degradation rate constants and activation energies at different temperatures. A possible degradation pathway of four carotenoids was identified to better understand the mechanism of carotenoid degradation.
[Mh] Termos MeSH primário: Carotenoides/análise
[Mh] Termos MeSH secundário: Cinética
Luteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
36-88-4 (Carotenoids); X72A60C9MT (Lutein)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  9 / 1956 MEDLINE  
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[PMID]:29053808
[Au] Autor:Akuffo KO; Beatty S; Peto T; Stack J; Stringham J; Kelly D; Leung I; Corcoran L; Nolan JM
[Ad] Endereço:Macular Pigment Research Group, Nutrition Research Centre Ireland, School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland.
[Ti] Título:The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related Macular Degeneration: A Head-to-Head Randomized Clinical Trial.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5347-5360, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: The purpose of this study was to evaluate the impact of supplemental macular carotenoids (including versus not including meso-zeaxanthin) in combination with coantioxidants on visual function in patients with nonadvanced age-related macular degeneration. Methods: In this study, 121 participants were randomly assigned to group 1 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mg meso-zeaxanthin; n = 60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose [25 mg] of zinc; n = 61). Visual function was assessed using best-corrected visual acuity, contrast sensitivity (CS), glare disability, retinal straylight, photostress recovery time, reading performance, and the National Eye Institute Visual Function Questionnaire-25. Macular pigment was measured using customized heterochromatic flicker photometry. Results: There was a statistically significant improvement in the primary outcome measure (letter CS at 6 cycles per degree [6 cpd]) over time (P = 0.013), and this observed improvement was statistically comparable between interventions (P = 0.881). Statistically significant improvements in several secondary outcome visual function measures (letter CS at 1.2 and 2.4 cpd; mesopic and photopic CS at all spatial frequencies; mesopic glare disability at 1.5, 3, and 6 cpd; photopic glare disability at 1.5, 3, 6, and 12 cpd; photostress recovery time; retinal straylight; mean and maximum reading speed) were also observed over time (P < 0.05, for all), and were statistically comparable between interventions (P > 0.05, for all). Statistically significant increases in macular pigment at all eccentricities were observed over time (P < 0.0005, for all), and the degree of augmentation was statistically comparable between interventions (P > 0.05). Conclusions: Antioxidant supplementation in patients with nonadvanced age-related macular degeneration results in significant increases in macular pigment and improvements in CS and other measures of visual function. (Clinical trial, http://www.isrctn.com/ISRCTN13894787).
[Mh] Termos MeSH primário: Antioxidantes/administração & dosagem
Luteína/uso terapêutico
Degeneração Macular/tratamento farmacológico
Pigmento Macular/uso terapêutico
Acuidade Visual/fisiologia
[Mh] Termos MeSH secundário: Idoso
Ácido Ascórbico/administração & dosagem
Sensibilidades de Contraste/fisiologia
Método Duplo-Cego
Quimioterapia Combinada
Feminino
Ofuscação
Seres Humanos
Degeneração Macular/fisiopatologia
Masculino
Meia-Idade
Fotometria/métodos
Leitura
Oligoelementos/administração & dosagem
Vitamina E/administração & dosagem
Zeaxantinas/uso terapêutico
Zinco/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antioxidants); 0 (Macular Pigment); 0 (Trace Elements); 0 (Zeaxanthins); 0 (meso-zeaxanthin); 1406-18-4 (Vitamin E); J41CSQ7QDS (Zinc); PQ6CK8PD0R (Ascorbic Acid); X72A60C9MT (Lutein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21192


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[PMID]:28893091
[Au] Autor:Chang CJ; Lin JF; Hsiao CY; Chang HH; Li HJ; Chang HH; Lee GA; Hung CF
[Ad] Endereço:* Division of Pediatric Surgery, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
[Ti] Título:Lutein Induces Autophagy via Beclin-1 Upregulation in IEC-6 Rat Intestinal Epithelial Cells.
[So] Source:Am J Chin Med;45(6):1273-1291, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Lutein is a carotenoid with anti-oxidant properties. Autophagy, an evolutionarily conserved catabolic cellular pathway for coping with stress conditions, is responsive to reactive oxygen species (ROS) and degrades damaged organelles. We previously demonstrated that lutein can induce anti-oxidant enzymes to relieve methotrexate-induced ROS stress. We therefore hypothesized that lutein, which activates ROS-scavenging enzymes, can also induce autophagy for cell survival. In this study, we demonstrated that lutein treatment attenuated the reduction in cell viability caused by H O . Lutein dose-dependently induced the processing of microtubule-associated protein light chain 3 (LC3)-II, an autophagy marker protein, and accumulation of LC3-positive puncta in rat intestinal IEC-6 cells. Furthermore, (a) direct observation of autophagosome formation through transmission electron microscopy, (b) upregulation of autophagy-related genes including ATG4A, ATG5, ATG7, ATG12, and beclin-1 (BENC1), and (c) increased BECN1/Bcl-2 ratio confirmed the induction of autophagy by lutein. The results revealed that bafilomycin-A1-induced inhibition of autophagy reduced cell viability and increased apoptosis in lutein-treated cells, indicating a protective role of lutein-induced autophagy. Lutein treatment also activated adenosine monophosphate-activated protein kinase (AMPK), c-Jun N-terminal kinase (JNK), and p-38, but had no effects on the induction of extracellular signal-related kinase or inhibition of mTOR; however, the inhibition of activated AMPK, JNK, or p-38 did not attenuate lutein-induced autophagy. Finally, increased BECN1 expression levels were detected in lutein-treated cells, and BECN1 knockdown abolished autophagy induction. These results suggest that lutein-induced autophagy was mediated by the upregulation of BECN1 in IEC-6 cells. We are the first to demonstrate that lutein induces autophagy. Elevated autophagy in lutein-treated IEC-6 cells may have a protective role against various stresses, and this warrants further investigation.
[Mh] Termos MeSH primário: Antioxidantes
Proteínas Relacionadas à Autofagia/genética
Proteínas Relacionadas à Autofagia/metabolismo
Autofagia/efeitos dos fármacos
Autofagia/genética
Beclina-1/genética
Beclina-1/metabolismo
Células Epiteliais/citologia
Células Epiteliais/fisiologia
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Regulação da Expressão Gênica no Desenvolvimento/genética
Intestinos/citologia
Luteína/farmacologia
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP/metabolismo
Animais
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/genética
Células Cultivadas
Relação Dose-Resposta a Droga
Depuradores de Radicais Livres/metabolismo
MAP Quinase Quinase 4/metabolismo
Proteínas Associadas aos Microtúbulos/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/genética
Ratos
Espécies Reativas de Oxigênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Autophagy-Related Proteins); 0 (Beclin-1); 0 (Free Radical Scavengers); 0 (LC3 protein, rat); 0 (Microtubule-Associated Proteins); 0 (Reactive Oxygen Species); EC 2.7.11.31 (AMP-Activated Protein Kinases); EC 2.7.12.2 (MAP Kinase Kinase 4); X72A60C9MT (Lutein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500707



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