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[PMID]:29311697
[Au] Autor:Qureshi BM; Schmidt A; Behrmann E; Bürger J; Mielke T; Spahn CMT; Heck M; Scheerer P
[Ad] Endereço:Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, D-10117, Berlin, Germany.
[Ti] Título:Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6.
[So] Source:Nat Commun;9(1):90, 2018 01 08.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Isoprenylated proteins are associated with membranes and their inter-compartmental distribution is regulated by solubilization factors, which incorporate lipid moieties in hydrophobic cavities and thereby facilitate free diffusion during trafficking. Here we report the crystal structure of a solubilization factor, the prenyl-binding protein (PrBP/δ), at 1.81 Å resolution in its ligand-free apo-form. Apo-PrBP/δ harbors a preshaped, deep hydrophobic cavity, capacitating apo-PrBP/δ to readily bind its prenylated cargo. To investigate the molecular mechanism of cargo solubilization we analyzed the PrBP/δ-induced membrane dissociation of rod photoreceptor phosphodiesterase (PDE6). The results suggest that PrBP/δ exclusively interacts with the soluble fraction of PDE6. Depletion of soluble species in turn leads to dissociation of membrane-bound PDE6, as both are in equilibrium. This "solubilization by depletion" mechanism of PrBP/δ differs from the extraction of prenylated proteins by the similar folded solubilization factor RhoGDI, which interacts with membrane bound cargo via an N-terminal structural element lacking in PrBP/δ.
[Mh] Termos MeSH primário: Proteínas de Transporte/metabolismo
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/metabolismo
Neopreno/metabolismo
Células Fotorreceptoras Retinianas Bastonetes/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Transporte/química
Bovinos
Cristalografia por Raios X
Nucleotídeo Cíclico Fosfodiesterase do Tipo 6/química
Modelos Moleculares
Complexos Multiproteicos/química
Complexos Multiproteicos/metabolismo
Neopreno/química
Ligação Proteica
Domínios Proteicos
Prenilação de Proteína
Subunidades Proteicas/química
Subunidades Proteicas/metabolismo
Inibidores da Dissociação do Nucleotídeo Guanina rho-Específico/química
Inibidores da Dissociação do Nucleotídeo Guanina rho-Específico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Multiprotein Complexes); 0 (Protein Subunits); 0 (prenyl); 0 (rho-Specific Guanine Nucleotide Dissociation Inhibitors); 9010-98-4 (Neoprene); EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 6)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02569-y


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[PMID]:28340291
[Au] Autor:Schwalen CJ; Feng X; Liu W; O-Dowd B; Ko TP; Shin CJ; Guo RT; Mitchell DA; Oldfield E
[Ad] Endereço:Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL, 61801, USA.
[Ti] Título:Head-to-Head Prenyl Synthases in Pathogenic Bacteria.
[So] Source:Chembiochem;18(11):985-991, 2017 Jun 01.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Many organisms contain head-to-head isoprenoid synthases; we investigated three such types of enzymes from the pathogens Neisseria meningitidis, Neisseria gonorrhoeae, and Enterococcus hirae. The E. hirae enzyme was found to produce dehydrosqualene, and we solved an inhibitor-bound structure that revealed a fold similar to that of CrtM from Staphylococcus aureus. In contrast, the homologous proteins from Neisseria spp. carried out only the first half of the reaction, yielding presqualene diphosphate (PSPP). Based on product analyses, bioinformatics, and mutagenesis, we concluded that the Neisseria proteins were HpnDs (PSPP synthases). The differences in chemical reactivity to CrtM were due, at least in part, to the presence of a PSPP-stabilizing arginine in the HpnDs, decreasing the rate of dehydrosqualene biosynthesis. These results show that not only S. aureus but also other bacterial pathogens contain head-to-head prenyl synthases, although their biological functions remain to be elucidated.
[Mh] Termos MeSH primário: Bactérias/enzimologia
Neopreno/metabolismo
Terpenos/metabolismo
[Mh] Termos MeSH secundário: Enterococcus hirae/enzimologia
Neisseria gonorrhoeae/enzimologia
Neisseria meningitidis/enzimologia
Fosfatos de Poli-Isoprenil/metabolismo
Prenilação
Esqualeno/análogos & derivados
Esqualeno/metabolismo
Staphylococcus aureus/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyisoprenyl Phosphates); 0 (Terpenes); 0 (prenyl); 11051-27-7 (dehydrosqualene); 29849-75-0 (presqualene pyrophosphate); 7QWM220FJH (Squalene); 9010-98-4 (Neoprene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170826
[Lr] Data última revisão:
170826
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700099


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[PMID]:28041850
[Au] Autor:Zhou Y; Prakash P; Liang H; Cho KJ; Gorfe AA; Hancock JF
[Ad] Endereço:Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, TX 77030, USA.
[Ti] Título:Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output.
[So] Source:Cell;168(1-2):239-251.e16, 2017 Jan 12.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras anchor binds selected plasma membrane anionic lipids with defined head groups and lipid side chains. The precise amino acid sequence and prenyl group define a combinatorial code for lipid binding that extends beyond simple electrostatics; within this code lysine and arginine residues are non-equivalent and prenyl chain length modifies nascent polybasic domain lipid preferences. The code is realized by distinct dynamic tertiary structures of the anchor on the plasma membrane that govern amino acid side-chain-lipid interactions. An important consequence of this specificity is the ability of such anchors when aggregated to sort subsets of phospholipids into nanoclusters with defined lipid compositions that determine K-Ras signaling output.
[Mh] Termos MeSH primário: Membrana Celular/metabolismo
Proteínas Proto-Oncogênicas p21(ras)/química
Proteínas Proto-Oncogênicas p21(ras)/metabolismo
[Mh] Termos MeSH secundário: Membrana Celular/química
Seres Humanos
Lipídeos/química
Modelos Moleculares
Simulação de Dinâmica Molecular
Mutação
Neopreno/química
Neopreno/metabolismo
Domínios Proteicos
Proteínas Proto-Oncogênicas p21(ras)/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KRAS protein, human); 0 (Lipids); 0 (prenyl); 9010-98-4 (Neoprene); EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170103
[St] Status:MEDLINE


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[PMID]:27129422
[Au] Autor:Ogawa T; Emi K; Koga K; Yoshimura T; Hemmi H
[Ad] Endereço:Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan.
[Ti] Título:A cis-prenyltransferase from Methanosarcina acetivorans catalyzes both head-to-tail and nonhead-to-tail prenyl condensation.
[So] Source:FEBS J;283(12):2369-83, 2016 06.
[Is] ISSN:1742-4658
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cis-prenyltransferase usually consecutively catalyzes the head-to-tail condensation reactions of isopentenyl diphosphate to allylic prenyl diphosphate in the production of (E,Z-mixed) polyprenyl diphosphate, which is the precursor of glycosyl carrier lipids. Some recently discovered homologs of the enzyme, however, catalyze the nonhead-to-tail condensation reactions between allylic prenyl diphosphates. In this study, we characterize a cis-prenyltransferase homolog from a methanogenic archaeon, Methanosarcina acetivorans, to obtain information on the biosynthesis of the glycosyl carrier lipids within it. This enzyme catalyzes both head-to-tail and nonhead-to-tail condensation reactions. The kinetic analysis shows that the main reaction of the enzyme is consecutive head-to-tail prenyl condensation reactions yielding polyprenyl diphosphates, while the chain lengths of the major products seem shorter than expected for the precursor of glycosyl carrier lipids. On the other hand, a subsidiary reaction of the enzyme, i.e., nonhead-to-tail condensation between dimethylallyl diphosphate and farnesyl diphosphate, gives a novel diterpenoid compound, geranyllavandulyl diphosphate.
[Mh] Termos MeSH primário: Lipídeos/química
Methanosarcina/enzimologia
Neopreno/metabolismo
Transferases/química
[Mh] Termos MeSH secundário: Catálise
Clonagem Molecular
Cinética
Lipídeos/biossíntese
Neopreno/química
Especificidade por Substrato
Transferases/genética
Transferases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipids); 0 (prenyl); 9010-98-4 (Neoprene); EC 2.- (Transferases); EC 2.5.1.- (cis-prenyl transferase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160501
[St] Status:MEDLINE
[do] DOI:10.1111/febs.13749


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[PMID]:27088717
[Au] Autor:Grecka E; Statkiewicz M; Gorska A; Biernacka M; Grygorowicz MA; Masnyk M; Chmielewski M; Gawarecka K; Chojnacki T; Swiezewska E; Malecki M
[Ad] Endereço:Department of Molecular and Translational Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
[Ti] Título:Prenyl Ammonium Salts--New Carriers for Gene Delivery: A B16-F10 Mouse Melanoma Model.
[So] Source:PLoS One;11(4):e0153633, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Prenyl ammonium iodides (Amino-Prenols, APs), semi-synthetic polyprenol derivatives were studied as prospective novel gene transfer agents. METHODS: AP-7, -8, -11 and -15 (aminoprenols composed of 7, 8, 11 or 15 isoprene units, respectively) were examined for their capacity to form complexes with pDNA, for cytotoxicity and ability to transfect genes to cells. RESULTS: All the carriers were able to complex DNA. The highest, comparable to commercial reagents, transfection efficiency was observed for AP-15. Simultaneously, AP-15 exhibited the lowest negative impact on cell viability and proliferation--considerably lower than that of commercial agents. AP-15/DOPE complexes were also efficient to introduce pDNA to cells, without much effect on cell viability. Transfection with AP-15/DOPE complexes influenced the expression of a very few among 44 tested genes involved in cellular lipid metabolism. Furthermore, complexes containing AP-15 and therapeutic plasmid, encoding the TIMP metallopeptidase inhibitor 2 (TIMP2), introduced the TIMP2 gene with high efficiency to B16-F10 melanoma cells but not to B16-F10 melanoma tumors in C57BL/6 mice, as confirmed by TIMP2 protein level determination. CONCLUSION: Obtained results indicate that APs have a potential as non-viral vectors for cell transfection.
[Mh] Termos MeSH primário: Compostos de Amônio/farmacologia
DNA/administração & dosagem
Sistemas de Liberação de Medicamentos
Terapia Genética
Melanoma Experimental/terapia
Neopreno/química
Sarcoma Experimental/terapia
[Mh] Termos MeSH secundário: Animais
Western Blotting
Sobrevivência Celular
Portadores de Fármacos
Feminino
Técnicas de Transferência de Genes
Técnicas Imunoenzimáticas
Lipossomos
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/secundário
Neoplasias Pulmonares/terapia
Melanoma Experimental/genética
Melanoma Experimental/patologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
RNA Mensageiro/genética
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Sarcoma Experimental/genética
Sarcoma Experimental/patologia
Transfecção
Células Tumorais Cultivadas
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ammonium Compounds); 0 (Drug Carriers); 0 (Liposomes); 0 (RNA, Messenger); 0 (prenyl); 9007-49-2 (DNA); 9010-98-4 (Neoprene)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0153633


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[PMID]:26618211
[Au] Autor:Wang M; Sun M; Hao H; Lu C
[Ad] Endereço:Engineering Research Center of Industrial Microbiology (Ministry of Education), College of Life Sciences, Fujian Normal University , Fuzhou, Fujian 350117, People's Republic of China.
[Ti] Título:Avertoxins A-D, Prenyl Asteltoxin Derivatives from Aspergillus versicolor Y10, an Endophytic Fungus of Huperzia serrata.
[So] Source:J Nat Prod;78(12):3067-70, 2015 Dec 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Aspergillus versicolor Y10 is an endophytic fungus isolated from Huperzia serrata, which showed inhibitory activity against acetylcholinesterase. An investigation of the chemical constituents of Y10 led to the isolation of four new prenylated asteltoxin derivatives, named avertoxins A-D (2-5), together with the known mycotoxin asteltoxin (1). In the present study, we report structure elucidation for 2-5 and the revised NMR assignments for asteltoxin and demonstrated that avertoxin B (3) is an active inhibitor against human acetylcholinesterase with the IC50 value of 14.9 µM (huperzine A as the positive control had an IC50 of 0.6 µM). In addition, the cytotoxicity of asteltoxin (1) and avertoxins A-D (2-5) against MDA-MB-231, HCT116, and HeLa cell lines was evaluated.
[Mh] Termos MeSH primário: Aspergillus/química
Inibidores da Colinesterase/isolamento & purificação
Huperzia/microbiologia
Pironas/isolamento & purificação
[Mh] Termos MeSH secundário: Alcaloides
Inibidores da Colinesterase/química
Inibidores da Colinesterase/farmacologia
Células HCT116
Células HeLa
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Neopreno
Ressonância Magnética Nuclear Biomolecular
Pironas/química
Pironas/farmacologia
Sesquiterpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Cholinesterase Inhibitors); 0 (Pyrones); 0 (Sesquiterpenes); 0 (prenyl); 0111871I23 (huperzine A); 72061-91-7 (asteltoxin); 9010-98-4 (Neoprene)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151224
[Lr] Data última revisão:
151224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151201
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00600


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[PMID]:26393932
[Au] Autor:Qin WF; Xiao T; Zhang D; Deng LF; Wang Y; Qin Y
[Ad] Endereço:The Innovative Drug Research Centre, and School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, P. R. China.
[Ti] Título:Total synthesis of (-)-depyranoversicolamide B.
[So] Source:Chem Commun (Camb);51(89):16143-6, 2015 Nov 18.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Starting from easily prepared (R)-C3-isoprenylated pyrroloindoline, the C3-isoprenylated indolyl diketopiperazine is prepared by an efficient reductive opening of the pyrrolo ring, and undergoes biomimetic Diels-Alder reaction to generate an anti-adduct as a sole stereoisomer. Oxidation of the indoline moiety to oxindole completes the synthesis of (-)-depyranoversicolamide B.
[Mh] Termos MeSH primário: Amidas/síntese química
Alcaloides de Indol/síntese química
Pirróis/química
[Mh] Termos MeSH secundário: Alcaloides de Indol/química
Indóis/química
Estrutura Molecular
Neopreno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Indole Alkaloids); 0 (Indoles); 0 (Pyrroles); 0 (depyranoversicolamide B); 0 (prenyl); 496-15-1 (indoline); 9010-98-4 (Neoprene)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151027
[Lr] Data última revisão:
151027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150923
[St] Status:MEDLINE
[do] DOI:10.1039/c5cc05877e


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[PMID]:26223944
[Au] Autor:Nieto J; Andrés C; Pérez-Encabo A
[Ad] Endereço:Instituto CINQUIMA and Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Valladolid, Paseo de Belén, 7, 47011 Valladolid, Spain. javiernr@qo.uva.es.
[Ti] Título:7-endo selenocyclization reactions on chiral 3-prenyl and 3-cinnamyl-2-hydroxymethylperhydro-1,3-benzoxazine derivatives. A way to enantiopure 1,4-oxazepanes.
[So] Source:Org Biomol Chem;13(34):9118-26, 2015 Sep 14.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Enantiopure 1,4-oxazepane derivatives have been prepared by selenocyclofunctionalization of chiral 3-prenyl- and 3-cinnamyl-2-hydroxymethyl-substituted perhydro-1,3-benzoxazine derivatives. The 7-endo-cyclization occurs in high yields and diastereoselection. The regio- and stereochemistry of the cyclization products was dependent on the substitution pattern of the double bond, the nature of the hydroxyl group and the experimental conditions.
[Mh] Termos MeSH primário: Benzoxazinas/química
Neopreno/química
Oxazepinas/síntese química
Selênio/química
[Mh] Termos MeSH secundário: Ciclização
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzoxazines); 0 (Oxazepines); 0 (prenyl); 9010-98-4 (Neoprene); H6241UJ22B (Selenium)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150820
[Lr] Data última revisão:
150820
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE
[do] DOI:10.1039/c5ob01297j


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[PMID]:26068123
[Au] Autor:Chang MY; Cheng YC; Lu YJ
[Ad] Endereço:Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
[Ti] Título:Synthesis of Substituted Benzenes via Bi(OTf)3-Mediated Intramolecular Carbonyl Allylation of α-Prenyl or α-Geranyl ß-Arylketosulfones.
[So] Source:Org Lett;17(12):3142-5, 2015 Jun 19.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intramolecular carbonyl allylation of α-prenyl or α-geranyl ß-arylketosulfones 5 in the presence of molecule sieves (MS) affords substituted benzenes 6-7 in moderate to good yields. The facile transformation proceeds by a synthetic sequence starting with the α-prenylation or α-geranylation of 1 and the Bi(OTf)3-mediated annulation of 5 followed by a sequential desulfonative aromatization or then an intramolecular Friedel-Crafts alkylation. A plausible mechanism has been studied and proposed.
[Mh] Termos MeSH primário: Benzeno/síntese química
Mesilatos/química
Neopreno/química
Compostos de Sulfidrila/química
[Mh] Termos MeSH secundário: Alquilação
Benzeno/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Mesylates); 0 (Sulfhydryl Compounds); 0 (prenyl); 51KD8E1741 (Bi(OTf)3); 9010-98-4 (Neoprene); J64922108F (Benzene)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150613
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.5b01461


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[PMID]:25925034
[Au] Autor:de Gusmão LC; Lima JS; Ramalho Jda R; Leite AL; da Silva AM
[Ad] Endereço:Universidade Federal de Alagoas (UFAL), Maceió, AL, Brazil; Colégio Brasileiro de Cirurgiões, Maceió, AL, Brazil.
[Ti] Título:Evaluation of brachial plexus fascicles involvement on infraclavicular block: unfixed cadaver study.
[So] Source:Braz J Anesthesiol;65(3):213-6, 2015 May-Jun.
[Is] ISSN:0104-0014
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: This study shows how the diffusion of the anesthetic into the sheath occurs through the axillary infraclavicular space and hence proves the efficacy of the anesthetic block of the brachial plexus, and may thereby allow a consolidation of this pathway, with fewer complications, previously attached to the anesthesia. MATERIALS AND METHODS: 33 armpits of adult cadavers were analyzed and unfixed. We injected a solution of neoprene with latex dye in the infraclavicular space, based on the technique advocated by Gusmão et al., and put the corpses in refrigerators for three weeks. Subsequently, the specimens were thawed and dissected, exposing the axillary sheath along its entire length. RESULTS AND DISCUSSION: Was demonstrated involvement of all fasciculus of the plexus in 51.46%. In partial involvement was 30.30%, 18.24% of cases the acrylic was located outside the auxiliary sheath involving no issue. CONCLUSIONS: The results allow us to establish the infraclavicular as an effective and easy way to access plexus brachial, because the solution involved the fascicles in 81.76% partially or totally, when it was injected inside the axillary sheath. We believe that only the use of this pathway access in practice it may demonstrate the efficiency.
[Mh] Termos MeSH primário: Bloqueio do Plexo Braquial/métodos
Plexo Braquial/metabolismo
Neopreno/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Cadáver
Feminino
Seres Humanos
Látex/administração & dosagem
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Latex); 9010-98-4 (Neoprene)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150501
[St] Status:MEDLINE



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