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[PMID]:28271736
[Au] Autor:Lv L; Zhang X; Qiao J
[Ad] Endereço:a College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse , Tongji University , Shanghai , People's Republic of China.
[Ti] Título:Flocculation of low algae concentration water using polydiallyldimethylammonium chloride coupled with polysilicate aluminum ferrite.
[So] Source:Environ Technol;39(1):83-90, 2018 Jan.
[Is] ISSN:0959-3330
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The combined application of polydiallyldimethylammonium chloride (PDADMAC) and polysilicate aluminum ferrite (PSFA) was investigated to treat low algae density water samples, in which Microcystis aeruginosa is one of the dominant species. coagulation performance of M. aeruginosa was studied with regard to algal removal, Algal density was evaluated by determining the change in the optical density of the algal culture suspension at 680 nm and chlorophyll a. The dissolved organic matter, cellular morphology, viability, and recovery of M. aeruginosa cells after flocculation and sedimentation were also included. In addition, the effects of pH and addition order of PSFA and PDADMAC on algal removal were investigated. The removal efficiency of algae coagulated using combined PDADMAC and PSFA was improved by 34.5% and 19.3%, respectively. The organic matter removal was also enhanced. The optimum pH range for algal removal is 7.0-10.0, and the preferable addition sequence is the simultaneous addition of PDADMAC and PSFA. Scanning electron microscopy observation indicated that the combined usage of PDADMAC and PSFA caused no damage to the algal cell. Moreover, the experiment on algal recovery demonstrated that PDADMAC has bacteriostatic ability.
[Mh] Termos MeSH primário: Polietilenos/química
Compostos de Amônio Quaternário/química
Eliminação de Resíduos Líquidos/métodos
[Mh] Termos MeSH secundário: Alumínio/química
Compostos Férricos/química
Floculação
Microalgas
Silicatos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Polyethylenes); 0 (Quaternary Ammonium Compounds); 0 (Silicates); 1317-54-0 (ferrite); 26062-79-3 (poly-N,N-dimethyl-N,N-diallylammonium chloride); CPD4NFA903 (Aluminum)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1080/09593330.2017.1296028


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[PMID]:29212681
[Au] Autor:Atrey A; Ward SE; Khoshbin A; Hussain N; Bogoch E; Schemitsch EH; Waddell JP
[Ad] Endereço:University of Toronto and St Michael's Hospital, 55 Queen Street E, Level 8, Toronto, Ontario M5C 1R6, Canada.
[Ti] Título:Ten-year follow-up study of three alternative bearing surfaces used in total hip arthroplasty in young patients: a prospective randomised controlled trial.
[So] Source:Bone Joint J;99-B(12):1590-1595, 2017 Dec.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: We present the ten-year data of a cohort of patients, aged between 18 and 65 years (mean age 52.7 years; 19 to 64), who underwent total hip arthroplasty. Patients were randomised to be treated with a cobalt-chrome (CoCr) femoral head with an ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE) or ceramic-on-ceramic (CoC) bearing surface. PATIENTS AND METHODS: A total of 102 hips (91 patients) were randomised into the three groups. At ten years, 97 hips were available for radiological and functional follow-up. Two hips (two patients) had been revised (one with deep infection and one for periprosthetic fracture) and three were lost to follow-up. Radiological analysis was performed using a validated digital assessment programme to give linear, directional and volumetric wear of the two polyethylene groups. RESULTS: There was a significantly reduced rate of steady-state linear wear with XLPE (0.07 mm/yr) compared with UHMWPE (0.37 mm/yr) (p = 0.001). Volumetric wear was also significantly reduced in the XLPE group (29.29 mm /yr) compared with the UHMWPE group (100.75mm /yr) (p = 0.0001). There were six patients with UHMWPE who had non-progressive osteolysis and none in the XLPE group. All three bearing groups had significant improvements in 12-item short form health survey scores, Western Ontario and McMaster Universities Osteoarthritis Index score and Harris Hip Score. However, the improvement in HSS was significantly less in the UHMWPE group (p = 0.0188) than in the other two groups. At ten years, the rates of volumetric and linear wear in the XLPE group remain low and predominantly below the estimated threshold for osteolysis (1 mm/yr). The rate of linear wear in the XLPE group was three times less than in the UHMWPE group at five-year follow-up and five times less at ten years. The rate of volumetric wear was also three times less in the XLPE group at ten years. CONCLUSION: While CoC also performs well, XLPE at ten years remains a safe and excellent bearing option in young patients, with low rates of wear and no evidence of osteolysis. Cite this article: 2017;99-B:1590-5.
[Mh] Termos MeSH primário: Artroplastia de Quadril/instrumentação
Articulação do Quadril/cirurgia
Prótese de Quadril
Artropatias/cirurgia
Desenho de Prótese
Falha de Prótese
[Mh] Termos MeSH secundário: Adulto
Artroplastia de Quadril/efeitos adversos
Materiais Biocompatíveis
Cerâmica
Ligas de Cromo
Cabeça do Fêmur/cirurgia
Seguimentos
Prótese de Quadril/efeitos adversos
Seres Humanos
Meia-Idade
Polietilenos
Estudos Prospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Chromium Alloys); 0 (Polyethylenes); 0 (ultra-high molecular weight polyethylene)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B12.BJJ-2017-0353.R1


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[PMID]:29097396
[Au] Autor:López-López JA; Humphriss RL; Beswick AD; Thom HHZ; Hunt LP; Burston A; Fawsitt CG; Hollingworth W; Higgins JPT; Welton NJ; Blom AW; Marques EMR
[Ad] Endereço:Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
[Ti] Título:Choice of implant combinations in total hip replacement: systematic review and network meta-analysis.
[So] Source:BMJ;359:j4651, 2017 Nov 02.
[Is] ISSN:1756-1833
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo: To compare the survival of different implant combinations for primary total hip replacement (THR).  Systematic review and network meta-analysis.  Medline, Embase, The Cochrane Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, and the EU Clinical Trials Register. Published randomised controlled trials comparing different implant combinations. Implant combinations were defined by bearing surface materials (metal-on-polyethylene, ceramic-on-polyethylene, ceramic-on-ceramic, or metal-on-metal), head size (large ≥36 mm or small <36 mm), and fixation technique (cemented, uncemented, hybrid, or reverse hybrid). Our reference implant combination was metal-on-polyethylene (not highly cross linked), small head, and cemented. The primary outcome was revision surgery at 0-2 years and 2-10 years after primary THR. The secondary outcome was the Harris hip score reported by clinicians. 77 studies were included in the systematic review, and 15 studies (3177 hips) in the network meta-analysis for revision. There was no evidence that the risk of revision surgery was reduced by other implant combinations compared with the reference implant combination. Although estimates are imprecise, metal-on-metal, small head, cemented implants (hazard ratio 4.4, 95% credible interval 1.6 to 16.6) and resurfacing (12.1, 2.1 to 120.3) increase the risk of revision at 0-2 years after primary THR compared with the reference implant combination. Similar results were observed for the 2-10 years period. 31 studies (2888 patients) were included in the analysis of Harris hip score. No implant combination had a better score than the reference implant combination. Newer implant combinations were not found to be better than the reference implant combination (metal-on-polyethylene (not highly cross linked), small head, cemented) in terms of risk of revision surgery or Harris hip score. Metal-on-metal, small head, cemented implants and resurfacing increased the risk of revision surgery compared with the reference implant combination. The results were consistent with observational evidence and were replicated in sensitivity analysis but were limited by poor reporting across studies. PROSPERO CRD42015019435.
[Mh] Termos MeSH primário: Artroplastia de Quadril/instrumentação
Prótese de Quadril
Metanálise em Rede
Falha de Prótese
Reoperação/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Cerâmica
Feminino
Seres Humanos
Masculino
Próteses Articulares Metal-Metal
Meia-Idade
Polietilenos
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; REVIEW
[Nm] Nome de substância:
0 (Polyethylenes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171119
[Lr] Data última revisão:
171119
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE
[do] DOI:10.1136/bmj.j4651


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[PMID]:28581826
[Au] Autor:Safwat MA; Soliman GM; Sayed D; Attia MA
[Ad] Endereço:a Department of Pharmaceutics, Faculty of Pharmacy , Assiut University , Assiut , Egypt.
[Ti] Título:Gold nanoparticles capped with benzalkonium chloride and poly (ethylene imine) for enhanced loading and skin permeability of 5-fluorouracil.
[So] Source:Drug Dev Ind Pharm;43(11):1780-1791, 2017 Nov.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To enhance 5-fluorouracil (5-FU) permeability through the skin by loading onto gold nanoparticles (GNPs) capped with two cationic ligands, benzalkonium chloride (BC) or poly (ethylene imine) (PEI). Whereas 5-FU has excellent efficacy against many cancers, its poor permeability through biological membranes and several adverse effects limit its clinical benefits. BC and PEI were selected to stabilize GNPs and to load 5-FU through ionic interactions. METHODS: 5-FU/BC-GNPs and 5-FU/PEI-GNPs were prepared at different 5-FU/ligand molar ratios and different pH values and were evaluated using different techniques. GNPs stability was tested as a function of salt concentration and storage time. 5-FU release from BC- and PEI-GNPs was evaluated as a function of solution pH. Ex vivo permeability studies of different 5-FU preparations were carried out using mice skin. RESULTS: 5-FU-loaded GNPs size and surface charge were dependent on the 5-FU/ligand molar ratios. 5-FU entrapment efficiency and loading capacity were dependent on the used ligand, 5-FU/ligand molar ratio and solution pH. Maximum drug entrapment efficiency of 59.0 ± 1.7% and 46.0 ± 1.1% were obtained for 5-FU/BC-GNPs and 5-FU/PEI-GNPs, respectively. 5-FU-loaded GNPs had good stability against salinity and after storage for 4 months at room temperature and at 4 °C. In vitro 5-FU release was pH- and ligand-dependent where slower release was observed at higher pH and for 5-FU/BC-GNPs. 5-FU permeability through mice skin was significantly higher for drug-loaded GNPs compared with drug-ligand complex or drug aqueous solution. CONCLUSION: Based on these results, BC- and PEI-GNPs might find applications as effective topical delivery systems of 5-FU.
[Mh] Termos MeSH primário: Compostos de Benzalcônio/química
Compostos de Benzalcônio/metabolismo
Fluoruracila/administração & dosagem
Ouro/administração & dosagem
Ouro/química
Iminas/química
Nanopartículas/química
Polietilenos/química
[Mh] Termos MeSH secundário: Animais
Portadores de Fármacos
Fluoruracila/química
Seres Humanos
Camundongos
Nanopartículas/administração & dosagem
Permeabilidade
Pele
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzalkonium Compounds); 0 (Drug Carriers); 0 (Imines); 0 (Polyethylenes); 0 (poly(ethylene imine)); 7440-57-5 (Gold); U3P01618RT (Fluorouracil)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1339082


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[PMID]:28415396
[Au] Autor:Alam F; Balani K
[Ad] Endereço:Biomaterials Processing and Characterization Laboratory, Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India.
[Ti] Título:Role of silver/zinc oxide in affecting de-adhesion strength of Staphylococcus aureus on polymer biocomposites.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:1106-1114, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A single-cell force spectroscopy is utilized to characterize the dynamics of the transient interaction (0-10s) between alive Staphylococcus aureus and ultra-high molecular weight polyethylene (UHMWPE). Adhesion force of bacteria upon addition of antibacterial additives (i.e. silver (Ag) nanoparticles and zinc oxide (ZnO) micro-rods) has been evaluated. Addition of Ag and ZnO reduces the colony forming units (CFUs) from 93±7 (UHMWPE) to 23±5 (U+3wt.% Ag+3wt.% ZnO) on 10×10mm area of sample surface. Presence of ZnO causes increase in the surface free energy from 29.1 (UHMWPE) to 32.3mJ/m (UHMWPE+1wt.% ZnO) and 32.3mJ/m for U+3wt.% ZnO whereas due to Ag the surface free energy decreased to 28.3mJ/m and 28.4mJ/m for UHMWPE+1wt.% Ag and U+3wt.% Ag respectively. At a contact time of 10s bacterial adhesion on U+1wt.% Ag+1wt.% ZnO, U+3wt.% Ag and U+3wt.% Ag+3wt.% ZnO showed lowest adhesion forces, ~2.6nN, ~2.9nN and ~3.2N respectively as compared to neat UHMWPE (~4nN) due to a lower surface free energies, but U+1wt.% Ag and U+1wt.% ZnO and U+3wt.% ZnO show higher adhesion force due their higher surface free energy. Ag nanoparticles reduce the live bacteria count whereas ZnO reduces the bacterial retention and combination of both acts synergistically so the count of live bacteria as well as total bacterial density reduced in U-Ag-ZnO composite samples.
[Mh] Termos MeSH primário: Aderência Bacteriana
Materiais Revestidos Biocompatíveis/química
Polietilenos/química
Prata/química
Staphylococcus aureus/crescimento & desenvolvimento
Óxido de Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 0 (Polyethylenes); 0 (ultra-high molecular weight polyethylene); 3M4G523W1G (Silver); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28336457
[Au] Autor:Li J; Zhang J; Wang Y; Liang X; Wusiman Z; Yin Y; Shen Q
[Ad] Endereço:School of Pharmacy, Shanghai Jiao Tong University,Dongchuan Road 800, Shanghai 200240, China.
[Ti] Título:Synergistic inhibition of migration and invasion of breast cancer cells by dual docetaxel/quercetin-loaded nanoparticles via Akt/MMP-9 pathway.
[So] Source:Int J Pharm;523(1):300-309, 2017 May 15.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Metastasis impedes the successful chemotherapy for breast cancer. In this study, an Akt inhibitor (quercetin, Qu) was co-delivered with a chemotherapeutic agent (docetaxel, DTX) by using hyaluronic acid (HA)-modified nanoparticles (NPs) as vectors to block metastasis. Dual DTX/Qu-loaded HA/polylactic-co-glycolic acid-polyethyleneimine NPs (PP-HA/NPs) were prepared through a modified emulsion solvent evaporation technique. The particle size of PP-HA/NPs with narrow polydispersity was 209.8±10.8nm. Wound healing assay revealed that Qu co-delivery and HA modification elicited synergistic inhibitory effects on cell motility. The downregulation of p-Akt and matrix metalloproteinase-9 (MMP-9) expression contributed to the significant inhibition of cell migration and invasion with inhibition rates of 95.6% and 99.3%, respectively. Further studies indicated that PP-HA/NPs could be efficiently uptaken by 4T1 breast cancer cells and could further induce cytotoxicity, decrease colony formation and promote cell apoptosis. Biodistribution assay demonstrated PP-HA/NPs also enhanced drug accumulation in the tumor and lungs and predicted that PP-HA/NPs could be employed as an effective therapy for primary tumor and pulmonary metastasis. Therefore, PP-HA/NPs could be a promising delivery system to treat metastatic breast cancer effectively.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Antioxidantes/administração & dosagem
Inibidores de Metaloproteinases de Matriz/administração & dosagem
Nanopartículas/administração & dosagem
Quercetina/administração & dosagem
Taxoides/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacocinética
Antioxidantes/química
Antioxidantes/farmacocinética
Apoptose/efeitos dos fármacos
Neoplasias da Mama
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Feminino
Ácido Hialurônico/administração & dosagem
Ácido Hialurônico/química
Ácido Hialurônico/farmacocinética
Iminas/administração & dosagem
Iminas/química
Iminas/farmacocinética
Ácido Láctico/administração & dosagem
Ácido Láctico/química
Ácido Láctico/farmacocinética
Metaloproteinase 9 da Matriz/metabolismo
Inibidores de Metaloproteinases de Matriz/química
Inibidores de Metaloproteinases de Matriz/farmacocinética
Camundongos Endogâmicos BALB C
Nanopartículas/química
Polietilenos/administração & dosagem
Polietilenos/química
Polietilenos/farmacocinética
Ácido Poliglicólico/administração & dosagem
Ácido Poliglicólico/química
Ácido Poliglicólico/farmacocinética
Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-akt/metabolismo
Quercetina/química
Quercetina/farmacocinética
Taxoides/química
Taxoides/farmacocinética
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Imines); 0 (Matrix Metalloproteinase Inhibitors); 0 (Polyethylenes); 0 (Taxoids); 0 (poly(ethylene imine)); 0 (polylactic acid-polyglycolic acid copolymer); 15H5577CQD (docetaxel); 26009-03-0 (Polyglycolic Acid); 33X04XA5AT (Lactic Acid); 9004-61-9 (Hyaluronic Acid); 9IKM0I5T1E (Quercetin); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.24.35 (Matrix Metalloproteinase 9); EC 3.4.24.35 (Mmp9 protein, mouse)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28283003
[Au] Autor:Wang C; Sun G; Wang Y; Kong N; Chi Y; Yang L; Xin Q; Teng Z; Wang X; Wen Y; Li Y; Xia G
[Ad] Endereço:a State Key Laboratories for Agrobiotechnology and College of Biological Sciences, China Agricultural University , Beijing , China.
[Ti] Título:Bacterial magnetic particles improve testes-mediated transgene efficiency in mice.
[So] Source:Drug Deliv;24(1):651-659, 2017 Nov.
[Is] ISSN:1521-0464
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nano-scaled materials have been proved to be ideal DNA carriers for transgene. Bacterial magnetic particles (BMPs) help to reduce the toxicity of polyethylenimine (PEI), an efficient gene-transferring agent, and assist tissue transgene ex vivo. Here, the effectiveness of the BMP-PEI complex-conjugated foreign DNAs (BPDs) in promoting testes-mediated gene transfer (TMGT) in mouse was compared with that of liposome-conjugated foreign DNAs. The results proved that through testes injection, the clusters of BPDs successfully reached the cytoplasm and the nuclear of spermatogenesis cell, and expressed in testes of transgene founder mice. Additionally, the ratio of founder mice obtained from BPDs (88%) is about 3 times higher than the control (25%) (p < 0.05). Interestingly, the motility of sperms recovered from epididymis of the founder mice from BPD group were significantly improved, as compared with the control (p < 0.01). Based on classic breeding, the ratio of transgene mice within the first filial was significantly higher in BPDs compared with the control (73.8% versus 11.6%, p < 0.05). TMGT in this study did not produce visible histological changes in the testis. In conclusion, nano-scaled BPDs could be an alternative strategy for efficiently producing transgene mice in vivo.
[Mh] Termos MeSH primário: Técnicas de Transferência de Genes
Proteínas de Fluorescência Verde/biossíntese
Proteínas de Fluorescência Verde/genética
Magnetossomos/genética
Magnetospirillum/genética
Espermatozoides/metabolismo
Testículo/metabolismo
Transgenes
[Mh] Termos MeSH secundário: Animais
Efeito Fundador
Regulação da Expressão Gênica
Genótipo
Iminas/química
Iminas/metabolismo
Lipossomos
Magnetossomos/metabolismo
Magnetospirillum/metabolismo
Masculino
Camundongos
Camundongos Transgênicos
Fenótipo
Polietilenos/química
Polietilenos/metabolismo
Motilidade Espermática
Espermatogênese
Testículo/citologia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Imines); 0 (Liposomes); 0 (Polyethylenes); 0 (poly(ethylene imine)); 147336-22-9 (Green Fluorescent Proteins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1080/10717544.2017.1293195


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[PMID]:28262019
[Au] Autor:Toivonen MS; Kurki-Suonio S; Wagermaier W; Hynninen V; Hietala S; Ikkala O
[Ad] Endereço:Molecular Materials, Department of Applied Physics, Aalto University (previously Helsinki University of Technology), P.O. Box 15100, FIN-00076 Aalto, Espoo, Finland.
[Ti] Título:Interfacial Polyelectrolyte Complex Spinning of Cellulose Nanofibrils for Advanced Bicomponent Fibers.
[So] Source:Biomacromolecules;18(4):1293-1301, 2017 Apr 10.
[Is] ISSN:1526-4602
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fiber spinning of anionic TEMPO-oxidized cellulose (TOCN) nanofibrils with polycations by interfacial polyelectrolyte complexation is demonstrated. The formed fibers were mostly composed of cellulose nanofibrils and the polycations were a minor constituent, leading to yield and ultimate strengths of ca. 100 MPa and ca. 200 MPa, and Young's modulus of ca. 15 GPa. Stretching of the as-formed wet filaments of TOCN/polycation by 20% increased the Young's modulus, yield strength, and ultimate tensile strength by approximately 45, 36, and 26%, respectively. Importantly, feasibility of compartmentalized wound bicomponent fibers by simultaneous spinning of two fibers of different compositions and entwining them together was shown. This possibility was further exploited to demonstrate reversible shape change of a bicomponent fiber directly by humidity change, and indirectly by temperature changes based on thermally dependent humidity absorption. The demonstrated route for TOCN-based fiber preparation is expected to open up new avenues in the application of nanocelluloses in advanced fibrous materials, crimping, and responsive smart textiles.
[Mh] Termos MeSH primário: Celulose Oxidada/química
Óxidos N-Cíclicos/química
Nanofibras/química
Polieletrólitos/química
Polietilenos/química
Compostos de Amônio Quaternário/química
[Mh] Termos MeSH secundário: Módulo de Elasticidade
Fenômenos Mecânicos
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Nanofibras/ultraestrutura
Reologia
Propriedades de Superfície
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cellulose, Oxidized); 0 (Cyclic N-Oxides); 0 (Polyelectrolytes); 0 (Polyethylenes); 0 (Quaternary Ammonium Compounds); 26062-79-3 (poly-N,N-dimethyl-N,N-diallylammonium chloride); VQN7359ICQ (TEMPO)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1021/acs.biomac.7b00059


  9 / 7601 MEDLINE  
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[PMID]:28231498
[Au] Autor:Hirano Y; Iwasaki Y
[Ad] Endereço:Graduate School of Science and Engineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka, 564-8680, Japan.
[Ti] Título:Bone-specific poly(ethylene sodium phosphate)-bearing biodegradable nanoparticles.
[So] Source:Colloids Surf B Biointerfaces;153:104-110, 2017 May 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chemotherapy is the most reliable treatment for osteoporosis and osseous metastases. To facilitate better drug delivery for bone treatments, a novel preparation of polymeric nanoparticles with high affinity to bone has been prepared. Two-step synthesis of cholesteryl-functionalized poly(ethylene sodium phosphate) (Ch-PEP ·Na) was performed via ring-opening polymerization of cyclic phosphoesters and the demethylation. The molecular weight of Ch-PEP ·Na could be well controlled by changing the ratio of cholesterol and cyclic phosphoesters. Because Ch-PEP ·Na exhibits an amphiphilic nature in aqueous media, Ch-PEP ·Na-bearing nanoparticles (PEP ·Na NPs) were prepared by a solvent evaporation technique. The size of the nanoparticles investigated in the current study is approximately 100nm, which was determined by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Due to the presence of highly water-soluble polymer chains, dispersion of PEP ·Na NPs in aqueous media was stable for at least 1 week. Hemolytic activity of PEP ·Na NPs was found to be low and PEP ·Na NPs did not disintegrate mammalian cell membranes. Additionally, cytotoxicity of PEP ·Na NPs was not observed at concentrations below 100µg/mL. The adsorption of PEP ·Na NPs on hydroxyapatite (HAp) microparticles was studied in comparison with poly(ethylene glycol) nanoparticles (PEG NPs). Both PEP ·Na NPs and PEG NPs adsorbed well onto HAp microparticles in distilled water with binding equilibrium constants (K ) for PEP ·Na NPs and PEG NPs of 3.6×10 and 7.9×10 , respectively. In contrast, only PEP ·Na NPs adsorbed onto HAp microparticles in a saline phosphate buffer. Moreover, the adsorption of PEP ·Na NPs onto HAp microparticles occurred even in the presence of 1.2mM calcium ions or low-pH media. The affinity of the nanoparticles to bovine bone slices was also studied, with the result that large quantities of adsorbed PEP ·Na NPs were observed on the slices by scanning electron microscope.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/metabolismo
Reabsorção Óssea/metabolismo
Nanopartículas/metabolismo
Polietilenos/metabolismo
[Mh] Termos MeSH secundário: Adsorção
Animais
Materiais Biocompatíveis/síntese química
Materiais Biocompatíveis/química
Bovinos
Linhagem Celular
Sobrevivência Celular
Teste de Materiais
Camundongos
Nanopartículas/química
Osteoclastos
Tamanho da Partícula
Polietilenos/síntese química
Polietilenos/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Polyethylenes); 0 (poly(ethylene sodium phosphate))
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


  10 / 7601 MEDLINE  
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[PMID]:28221711
[Au] Autor:Morioka T; Nakano K; Tominaga Y
[Ad] Endereço:Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei, Tokyo, 184-8588, Japan.
[Ti] Título:Ion-Conductive Properties of a Polymer Electrolyte Based on Ethylene Carbonate/Ethylene Oxide Random Copolymer.
[So] Source:Macromol Rapid Commun;38(8), 2017 Apr.
[Is] ISSN:1521-3927
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A random copolymer of ethylene oxide with CO , namely, poly(ethylene carbonate/ethylene oxide) (P(EC/EO)), has been synthesized as a novel candidate for polymer electrolytes. Electrolyte composed of P(EC/EO) and lithium bis(fluorosulfonyl)imide has an ionic conductivity of 0.48 mS cm and a Li transference number (t ) of 0.66 at 60 °C. To study ion-conductive behavior of P(EC/EO)-based electrolytes, the Fourier transform infrared (FT-IR) technique is used to analyze the interactions between Li and functional groups of the copolymer. The carbonate groups may interact preferentially with Li rather than the ether groups in P(EC/EO). This study suggests that copolymerization of carbonate and flexible ether units can realize both high conductivity and t for polymer electrolytes. High-performance P(EC/EO) electrolyte is expected to be a candidate material for use in all-solid-state batteries.
[Mh] Termos MeSH primário: Eletrólitos/química
Polietilenoglicóis/química
Polietilenos/química
Polímeros/química
[Mh] Termos MeSH secundário: Carbonatos/química
Condutividade Elétrica
Imidas/química
Íons/química
Lítio/química
Estrutura Molecular
Peso Molecular
Compostos Orgânicos/química
Espectroscopia de Infravermelho com Transformada de Fourier
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbonates); 0 (Electrolytes); 0 (Imides); 0 (Ions); 0 (Organic Chemicals); 0 (Polyethylenes); 0 (Polymers); 25718-55-2 (polyethylene carbonate); 30IQX730WE (Polyethylene Glycols); 9FN79X2M3F (Lithium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170222
[St] Status:MEDLINE
[do] DOI:10.1002/marc.201600652



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