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[PMID]:29489681
[Au] Autor:Kim CO; Song J; Min JY; Park SJ; Lee HM; Byon HJ
[Ad] Endereço:Department of Clinical Pharmacology and Clinical Trials Center, Severance Hospital, Yonsei University Health System, Seodaemun-gu, Seoul.
[Ti] Título:A comparison of the pharmacokinetic and pharmacodynamic properties of nitroglycerin according to the composition of the administration set: A preliminary study.
[So] Source:Medicine (Baltimore);97(9):e9829, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a risk of drug sorption into an intravenous administration set composed of polyvinyl chloride (PVC), polyurethane (PU), or polyolefin (PO). This has implications on the dose of the active ingredient the patient receives, and thus therapeutic success. This study aimed to determine the plasma concentration of nitroglycerin and the effect of nitroglycerin on patients based on the composition of the administration set. METHODS: Using a randomized, open-labeled, 3 × 3 crossover method, 9 volunteers were assigned to 3 groups. In period I, nitroglycerin (100 µg/mL) was infused via a PVC- (group A), PU- (group B), or PO-based (group C) administration set. In period II, PU- (group A), PO- (group B), and PVC-based (group C) administration sets were used, and in period III, PO- (group A), PVC- (group B), and PU-based (group C) administration sets were used. The rate of drug administration in all periods was 12 mL/hour for 30 minutes using an infusion pump. Blood samples were collected, and the plasma concentrations of nitroglycerin were analyzed using validated high-performance liquid chromatography coupled with tandem mass spectrometry. Blood pressure was determined using a sphygmomanometer applied to the other upper arm at an interval of 5 minutes. RESULTS: We observed that the mean plasma concentration of nitroglycerin over time when administered using a PO-based tube was higher than that when using a PU- or PVC-based tube. When the percent change of the mean arterial pressure from baseline at each time point was compared among groups, there were statistically significant differences between PU and PO or PVC at most points during nitroglycerin infusion. CONCLUSION: Our results showed higher nitroglycerin plasma concentration and lower arterial pressure when a PO-based administration set was used than when a PVC- or PU-based administration set was used. PO-based administration sets may be more appropriate for nitroglycerin administration compared to those composed of PVC or PU.
[Mh] Termos MeSH primário: Administração Intravenosa/instrumentação
Desenho de Equipamento
Bombas de Infusão
Nitroglicerina/farmacocinética
Vasodilatadores/farmacocinética
[Mh] Termos MeSH secundário: Administração Intravenosa/métodos
Adulto
Pressão Sanguínea
Cromatografia Líquida/métodos
Estudos Cross-Over
Seres Humanos
Masculino
Meia-Idade
Nitroglicerina/administração & dosagem
Nitroglicerina/sangue
Polienos
Poliuretanos
Cloreto de Polivinila
Espectrometria de Massas em Tandem
Vasodilatadores/administração & dosagem
Vasodilatadores/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Polyenes); 0 (Polyurethanes); 0 (Vasodilator Agents); 83136-87-2 (PL 732); 9002-86-2 (Polyvinyl Chloride); G59M7S0WS3 (Nitroglycerin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009829


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[PMID]:28466544
[Au] Autor:Loza-Correa M; Kalab M; Yi QL; Eltringham-Smith LJ; Sheffield WP; Ramirez-Arcos S
[Ad] Endereço:Canadian Blood Services, Centre for Innovation, Ottawa, ON, Canada.
[Ti] Título:Comparison of bacterial attachment to platelet bags with and without preconditioning with plasma.
[So] Source:Vox Sang;112(5):401-407, 2017 Jul.
[Is] ISSN:1423-0410
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Canadian Blood Services produces apheresis and buffy coat pooled platelet concentrates (PCs) stored in bags produced by two different manufacturers (A and B, respectively), both made of polyvinyl chloride-butyryl trihexyl citrate. This study was aimed at comparing Staphylococcus epidermidis adhesion to the inner surface of both bag types in the presence or absence of plasma factors. MATERIALS AND METHODS: Sets (N = 2-6) of bags type A and B were left non-coated (control) or preconditioned with platelet-rich, platelet-poor or defibrinated plasma (PRP, PPP and DefibPPP, respectively). Each bag was inoculated with a 200-ml S. epidermidis culture adjusted to 0·5 colony-forming units/ml. Bags were incubated under platelet storage conditions for 7 days. After culture removal, bacteria attached to the plastic surface were either dislodged by sonication for bacterial quantification or examined in situ by scanning electron microscopy (SEM). RESULTS: Higher bacterial adhesion was observed to preconditioned PC bags than control containers for both bag types (P < 0·0001). Bacterial attachment to preconditioned bags was confirmed by SEM. Bacteria adhered equally to both types of containers in the presence of PRP, PPP and DefibPPP residues (P > 0·05). By contrast, a significant increase in bacterial adherence was observed to type A bags compared with type B bags in the absence of plasma (P < 0·05) [Correction added on 16 June 2017, after first online publication: this sentence has been corrected]. CONCLUSION: The ability of S. epidermidis to adhere to preconditioned platelet collection bags depends on the presence of plasma factors. Future efforts should be focused on reducing plasma proteins' attachment to platelet storage containers to decrease subsequent bacterial adhesion.
[Mh] Termos MeSH primário: Incrustação Biológica/prevenção & controle
Plaquetas
Preservação de Sangue/instrumentação
Staphylococcus epidermidis/fisiologia
[Mh] Termos MeSH secundário: Aderência Bacteriana
Materiais Revestidos Biocompatíveis
Seres Humanos
Plasma/química
Cloreto de Polivinila/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 9002-86-2 (Polyvinyl Chloride)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1111/vox.12513


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[PMID]:28847108
[Au] Autor:Ke C; Ma X; Tang Y; Zheng W; Wu Z
[Ad] Endereço:Guangdong Province Key Laboratory of Efficient and Clean Energy Utilization, School of Electric Power, South China University of Technology, 510640 Guangzhou, China.
[Ti] Título:The volatilization of heavy metals during co-combustion of food waste and polyvinyl chloride in air and carbon dioxide/oxygen atmosphere.
[So] Source:Bioresour Technol;244(Pt 1):1024-1030, 2017 Nov.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The volatilization of three heavy metals (Cd, Cr and Zn) during food waste and PVC and their blending combustion in N /O or CO /O atmosphere in a lab-scale tubular furnace was investigated. The concentration of heavy metals in combustion ash was decreased with the increment of furnace temperature in most cases. The replacement of 80N /20O by 80CO /20O decreased the volatilization rate of Cd and Cr, but increased Zn. The increased amount of PVC added into food waste led to less content of Zn in combustion ash, 5% PVC added into food waste decreased the volatilization rate of Cr but 15% PVC added led to the higher volatilization. The volatilization rate of Zn in 70CO /30O was significantly lower than in 85CO /15O or 80CO /20O . The result contributes to the understanding of heavy metal volatilization during incineration and emission control of MSW oxy-fuel combustion.
[Mh] Termos MeSH primário: Metais Pesados
Cloreto de Polivinila
Eliminação de Resíduos
[Mh] Termos MeSH secundário: Dióxido de Carbono
Alimentos
Incineração
Oxigênio
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 142M471B3J (Carbon Dioxide); 9002-86-2 (Polyvinyl Chloride); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170830
[St] Status:MEDLINE


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[PMID]:28696102
[Au] Autor:Zhan F; Zhang H; Wang J; Xu J; Yuan H; Gao Y; Su F; Chen J
[Ad] Endereço:CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian, 116023, China.
[Ti] Título:Release and Gas-Particle Partitioning Behaviors of Short-Chain Chlorinated Paraffins (SCCPs) During the Thermal Treatment of Polyvinyl Chloride Flooring.
[So] Source:Environ Sci Technol;51(16):9005-9012, 2017 Aug 15.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chlorinated paraffin (CP) mixture is a common additive in polyvinyl chloride (PVC) products as a plasticizer and flame retardant. During the PVC plastic life cycle, intentional or incidental thermal processes inevitably cause an abrupt release of short-chain CPs (SCCPs). In this study, the thermal processing of PVC plastics was simulated by heating PVC flooring at 100-200 °C in a chamber. The 1 h thermal treatment caused the release of 1.9-10.7% of the embedded SCCPs. A developed emission model indicated that SCCP release was mainly controlled by material-gas partitioning at 100 °C. However, release control tended to be subjected to material-phase diffusion above 150 °C, especially for SCCP congeners with shorter carbon-chain lengths. A cascade impactor (NanoMoudi) was used to collect particles of different sizes and gas-phase SCCPs. The elevated temperature resulted in a higher partition of SCCPs from the gas-phase to particle-phase. SCCPs were not strongly inclined to form aerosol particles by nucleation, and less present in the Aitken mode particles. Junge-Pankow adsorption model well fitted the partitioning of SCCPs between the gas-phase and accumulation mode particles. Inhalation exposure estimation indicated that PVC processing and recycling workers could face a considerably high risk for exposure to SCCPs.
[Mh] Termos MeSH primário: Exposição Ocupacional
Parafina
Cloreto de Polivinila
[Mh] Termos MeSH secundário: Monitoramento Ambiental
Seres Humanos
Hidrocarbonetos Clorados
Exposição por Inalação
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Chlorinated); 8002-74-2 (Paraffin); 9002-86-2 (Polyvinyl Chloride)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b01965


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[PMID]:28637458
[Au] Autor:Marie C; Hamlaoui S; Bernard L; Bourdeaux D; Sautou V; Lémery D; Vendittelli F; Sauvant-Rochat MP
[Ad] Endereço:Axe TGI-PEPRADE, Institut Pascal, Sigma Clermont, CNRS, Université Clermont Auvergne, 63001, Clermont-Ferrand, France. cmarie@chu-clermontferrand.fr.
[Ti] Título:Exposure of hospitalised pregnant women to plasticizers contained in medical devices.
[So] Source:BMC Womens Health;17(1):45, 2017 Jun 20.
[Is] ISSN:1472-6874
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Medical devices (MDs) in polyvinyl chloride (PVC) are not a well-known source of exposure to plasticizers, in particular during pregnancy. Because of its toxicity, the di-(2-ethylhexyl) phthalate (DEHP) has been replaced by other plasticizers such as di (isononyl)-cyclohexane-1,2-dicarboxilic acid (DINCH), tri-octyltrimellitate (TOTM) and di-(isononyl) phthalate (DiNP). Our study aimed to quantify the plasticizers (DEHP and alternative plasticizers) contained in PVC medical devices used for hospitalised pregnant women and to describe which these MDs had been used (type, number, duration of exposure). METHODS: The plasticizers contained in the MDs used for daily care in the Obstetrics Department of a French University Hospital were extracted from PVC (after contact with a chloroform solution), identified and quantified by gas-chromatography-mass-spectrometry analysis. A total of 168 pregnant women hospitalised in the Obstetrics Department with at least one catheter were included in the observational study. The median number of MDs containing plasticizers used and the daily duration of exposure to the MDs were compared in three groups of pregnant women: "Pathology group" (women hospitalised for an obstetric disorder who did not give birth during this hospitalisation; n = 52), "Pathology and delivery group" (hospitalised for an obstetric disorder and who gave birth during this stay; n = 23) and "Delivery group" (admitted for planned or spontaneous delivery without obstetric disorder; n = 93). RESULTS: DiNP, TOTM and DINCH were the predominant plasticizers contained in the MDs at an amount of 29 to 36 g per 100 g of PVC. Women in the "Pathology group" (preterm labour or other pathology) were exposed to a median number of two MDs containing TOTM and one MD containing DiNP, fewer than those in the "Pathology and delivery group" (p < 0.05). Women in the "Pathology group" had a median exposure of 3.4 h/day to MDs containing DiNP and 8.2 h/day to MDs containing TOTM, longer than those in the "Delivery group" (p < 0.01). CONCLUSIONS: Our study shows that the medical management of pregnant women in a hospital setting entails exposure to MDs containing alternative plasticizers (DiNP, TOTM and DINCH).
[Mh] Termos MeSH primário: Equipamentos e Provisões
Hospitalização
Exposição Materna
Plastificantes/análise
Cloreto de Polivinila/análise
[Mh] Termos MeSH secundário: Adulto
Benzoatos/análise
Ácidos Cicloexanocarboxílicos/análise
Ácidos Dicarboxílicos/análise
Feminino
Seres Humanos
Ácidos Ftálicos/análise
Gravidez
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Benzoates); 0 (Cyclohexanecarboxylic Acids); 0 (Dicarboxylic Acids); 0 (Phthalic Acids); 0 (Plasticizers); 0 (diisononyl 1,2-cyclohexanedicarboxylic acid); 6O7F7IX66E (phthalic acid); 9002-86-2 (Polyvinyl Chloride); 9GPJ04URH3 (trioctyl trimellitate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1186/s12905-017-0398-7


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[PMID]:28490663
[Au] Autor:Mundt KA; Dell LD; Crawford L; Gallagher AE
[Ad] Endereço:Department of Health Sciences, Ramboll Environ, Amherst, Massachusetts, USA.
[Ti] Título:Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013.
[So] Source:Occup Environ Med;74(10):709-716, 2017 Oct.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013. METHODS: SMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure. RESULTS: Liver cancer mortality was elevated (SMR=2.87, 95% CI 2.40 to 3.40), and ASL and HCC were strongly associated with cumulative VC exposure ≥865 parts per million-years (ppm-years) (ASL: HR=36.3, 95% CI 13.1 to 100.5; and HCC: HR=5.3, 95% CI 1.6 to 17.7 for ≥2271 ppm-years). Excess deaths due to connective and soft tissue cancers (SMR=2.43, 95% CI 1.48 to 3.75), mesothelioma (SMR=2.29, 95% CI 1.18 to 4.00) and explosions (SMR=3.43, 95% CI 1.25 to 7.47) were seen. Mortalities due to melanoma, brain cancer, lung cancer and non-Hodgkin's lymphoma were not increased or associated with VC exposure. CONCLUSION: The association between VC and ASL first reported in this cohort 44 years ago persisted and was strongest among workers most highly exposed. VC exposure also was associated with HCC mortality, although it remains possible that misdiagnosis of early ASLs influenced findings.
[Mh] Termos MeSH primário: Hemangiossarcoma/mortalidade
Neoplasias Hepáticas/mortalidade
Indústria Manufatureira
Doenças Profissionais/mortalidade
Exposição Ocupacional/efeitos adversos
Cloreto de Polivinila/efeitos adversos
Cloreto de Vinil/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Causas de Morte
Seres Humanos
Fígado/efeitos dos fármacos
Masculino
Meia-Idade
Modelos de Riscos Proporcionais
Risco
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9002-86-2 (Polyvinyl Chloride); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-104051


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[PMID]:28415515
[Au] Autor:Abdel-Haleem FM; Rizk MS
[Ad] Endereço:Chemistry department, Faculty of Science, Cairo university, Giza, Egypt. Electronic address: fatehy@sci.cu.edu.eg.
[Ti] Título:Highly selective thiocyanate optochemical sensor based on manganese(III)-salophen ionophore.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:682-687, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We report on the development of optochemical sensor based on Mn(III)-salophen ionophore. The sensor was prepared by embedding the ionophore in a plasticized poly (vinyl chloride) impregnated with the chromoionophore ETH7075. Optical response to thiocyanate occurred due to thiocyanate extraction into the polymer via formation of strong complex with the ionophore and simultaneous protonation of the indicator dye yielding the optical response at 545nm. The developed optochemical sensor exhibited high selectivity for thiocyanate over other anions including the most lipophilic species such as salicylate and perchlorate. For instance, the optical selectivity coefficients, logK , were as follow: ClO =-5.8; Sal =-4.0; NO Ë‚-6. Further, the thiocyanate optical selectivity obtained using the present optochemical sensor was greatly enhanced in comparison with that obtained using an anion-exchanger based sensor. Also, the optimized optochemical sensor exhibited micro-molar detection limit with 2min response time at pH4.5 using acetate buffer. The reversibility of the optimized sensor was poor due to strong ligation of the thiocyanate to the central Metal ion, log K=14.1, which can be overcome by soaking the optode in sodium hydroxide followed by soaking in buffer solution. The developed sensor was utilized successfully for the determination of thiocyanate in human saliva and in spiked saliva samples.
[Mh] Termos MeSH primário: Ionóforos/química
Manganês/química
Salicilatos/química
Tiocianatos/análise
[Mh] Termos MeSH secundário: Concentração de Íons de Hidrogênio
Cloreto de Polivinila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ionophores); 0 (Salicylates); 0 (Thiocyanates); 118-57-0 (salophen); 302-04-5 (thiocyanate); 42Z2K6ZL8P (Manganese); 9002-86-2 (Polyvinyl Chloride)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28415468
[Au] Autor:Al Salloum H; Saunier J; Dazzi A; Vigneron J; Etcheberry A; Marlière C; Aymes-Chodur C; Herry JM; Bernard M; Jubeli E; Yagoubi N
[Ad] Endereço:IFR 141, EA 401, UFR de Pharmacie, Univ. Paris Sud - Université Paris-Saclay, 92290 Chatenay Malabry, France.
[Ti] Título:Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing.
[So] Source:Mater Sci Eng C Mater Biol Appl;75:317-334, 2017 Jun 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.
[Mh] Termos MeSH primário: Preservação de Sangue/instrumentação
Cloreto de Polivinila/química
[Mh] Termos MeSH secundário: Preservação de Sangue/métodos
Seres Humanos
Lubrificantes/química
Estearatos/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lubricants); 0 (Stearates); 9002-86-2 (Polyvinyl Chloride)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE


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[PMID]:28352177
[Au] Autor:Machado MC; Webster TJ
[Ad] Endereço:Center for Biomedical Engineering, Division of Engineering Brown University, Providence, RI.
[Ti] Título:Lipase degradation of plasticized polyvinyl chloride endotracheal tube surfaces to create nanoscale features.
[So] Source:Int J Nanomedicine;12:2109-2115, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Polyvinyl chloride (PVC) endotracheal tubes (ETTs) nanoetched with a fungal lipase have been shown to reduce bacterial growth and biofilm formation and could be an inexpensive solution to the complex problem of ventilator-associated pneumonia (VAP). Although bacterial growth and colonization on these nanoetched materials have been well characterized, little is known about the mechanism by which the fungal lipase degrades the PVC and, thus, alters its properties to minimize bacteria functions. This study used X-ray photoelectron spectroscopy (XPS) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) to better describe the surface chemistry of both unetched and lipase nanoetched PVC ETT. ATR-FTIR analysis of the unetched and treated surfaces showed a similar presence of a plasticizer. This was confirmed by XPS analysis, which showed an increase of carbon and the presence of oxygen on both unetched and nanoetched surfaces. A quantitative comparison of the FTIR spectra revealed significant correlations (Pearson's correlation, =0.997 [ =0.994, <0.001]) between the unetched and nanomodified PVC ETT spectra, demonstrating similar surface chemistry. This analysis showed no shifting or widening of the bands in the spectra and no significant changes in the intensity of the infrared peaks due to the degradation of the plasticizer by the fungal lipase. In contrast, results from this study did demonstrate significantly increased nanoscale surface features on the lipase etched compared to non-etched PVC ETTs. This led to a change in surface energetics, which altered ion adsorption to the ETTs. Thus, these results showed that PVC surfaces nanoetched with a 0.1% lipase solution for 48 hours have no significant change on surface chemistry but do significantly increase nanoscale surface roughness and alters ion adsorption, which suggests that the unique properties of these materials, including their previously reported ability to decrease bacterial adhesion and growth, are due to the changes in the degree of the nanoscale roughness, not changes in their surface chemistry.
[Mh] Termos MeSH primário: Intubação Intratraqueal
Lipase/metabolismo
Nanopartículas/química
Plastificantes/farmacologia
Cloreto de Polivinila/farmacologia
Proteólise/efeitos dos fármacos
[Mh] Termos MeSH secundário: Hidrólise
Espectroscopia Fotoeletrônica
Rhizopus/enzimologia
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plasticizers); 9002-86-2 (Polyvinyl Chloride); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170330
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S130608


  10 / 3100 MEDLINE  
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[PMID]:28346210
[Au] Autor:McCluskey SV; Kirkham K; Munson JM
[Ad] Endereço:Mayo Clinic Rochester, Rochester, Minnesota. mccluskey.susan@mayo.edu.
[Ti] Título:Stability of Alprostadil in 0.9% Sodium Chloride Stored in Polyvinyl Chloride Containers.
[So] Source:Int J Pharm Compd;21(2):150-153, 2017 Mar-Apr.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The stability of alprostadil diluted in 0.9% sodium chloride stored in polyvinyl chloride (VIAFLEX) containers at refrigerated temperature, protected from light, is reported. Five solutions of alprostadil 11 mcg/mL were prepared in 250 mL 0.9% sodium chloride polyvinyl chloride (PL146) containers. The final concentration of alcohol was 2%. Samples were stored under refrigeration (2°C to 8°C) with protection from light. Two containers were submitted for potency testing and analyzed in duplicate with the stability-indicating high-performance liquid chromatography assay at specific time points over 14 days. Three containers were submitted for pH and visual testing at specific time points over 14 days. Stability was defined as retention of 90% to 110% of initial alprostadil concentration, with maintenance of the original clear, colorless, and visually particulate-free solution. Study results reported retention of 90% to 110% initial alprostadil concentration at all time points through day 10. One sample exceeded 110% potency at day 14. pH values did not change appreciably over the 14 days. There were no color changes or particle formation detected in the solutions over the study period. This study concluded that during refrigerated, light-protected storage in polyvinyl chloride (VIAFLEX) containers, a commercial alcohol-containing alprostadil formulation diluted to 11 mcg/mL with 0.9% sodium chloride 250 mL was stable for 10 days.
[Mh] Termos MeSH primário: Alprostadil/química
Embalagem de Medicamentos
Excipientes/química
Inibidores da Agregação de Plaquetas/química
Cloreto de Polivinila/química
Cloreto de Sódio/química
Vasodilatadores/química
[Mh] Termos MeSH secundário: Alprostadil/farmacologia
Alprostadil/efeitos da radiação
Cromatografia Líquida de Alta Pressão
Temperatura Baixa
Composição de Medicamentos
Estabilidade de Medicamentos
Armazenamento de Medicamentos
Concentração de Íons de Hidrogênio
Soluções Isotônicas
Luz
Inibidores da Agregação de Plaquetas/farmacologia
Inibidores da Agregação de Plaquetas/efeitos da radiação
Cloreto de Sódio/efeitos da radiação
Fatores de Tempo
Vasodilatadores/farmacologia
Vasodilatadores/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Isotonic Solutions); 0 (Platelet Aggregation Inhibitors); 0 (Vasodilator Agents); 451W47IQ8X (Sodium Chloride); 9002-86-2 (Polyvinyl Chloride); F5TD010360 (Alprostadil)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE



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