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  1 / 108 MEDLINE  
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[PMID]:25487349
[Au] Autor:Liu W; Wang J; Yu Y; Chang Y; Tang N; Qu H; Wang Y; Pang W; Zhang H; Zhang D; Xu H; Duan X
[Ad] Endereço:State Key Laboratory of Precision Measuring Technology & Instruments, College of Precision Instrument and Optoelectronics Engineering, Tianjin University , Tianjin 300072, China.
[Ti] Título:Tuning the resonant frequency of resonators using molecular surface self-assembly approach.
[So] Source:ACS Appl Mater Interfaces;7(1):950-8, 2015 Jan 14.
[Is] ISSN:1944-8252
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this work, a new method to tune the resonant frequency of microfabricated resonator using molecular layer-by-layer (LbL) self-assembly approach is demonstrated. By simply controlling the polymer concentration and the number of layers deposited, precisely tuning the frequency of microfabricated resonators is realized. Due to its selective deposition through specific molecular recognitions, such technique avoids the high-cost and complex steps of conventional semiconductor fabrications and is able to tune individual diced device. Briefly, film bulk acoustic resonator (FBAR) is used to demonstrate the tuning process and two types of LbL deposition methods are compared. The film thickness and morphology have been characterized by UV-vis reflection spectra, ellipsometer and AFM. As a result, the maximum resonant frequency shift of FBAR reaches more than 20 MHz, meaning 1.4% tunability at least. The minimum frequency shift is nearly 10 kHZ per bilayer, indicating 7 ppm tuning resolution. Pressure cooker test (PCT) is performed to evaluate the reliability of LbL coated FBAR. Furthermore, applications for wireless broadband communication and chemical sensors of LbL coated FBAR have been demonstrated.
[Mh] Termos MeSH primário: Acústica
Resinas Acrílicas/química
Oxigênio/química
N-Óxido de Polivinilpiridina/química
[Mh] Termos MeSH secundário: Algoritmos
Monitoramento Ambiental/métodos
Filtração
Gases
Teste de Materiais
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Pressão
Reprodutibilidade dos Testes
Propriedades de Superfície
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acrylic Resins); 0 (Gases); 059QF0KO0R (Water); 4Q93RCW27E (carbopol 940); 9016-06-2 (Polyvinylpyridine N-Oxide); S88TT14065 (Oxygen)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141210
[St] Status:MEDLINE
[do] DOI:10.1021/am507640g


  2 / 108 MEDLINE  
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[PMID]:22899420
[Au] Autor:Tonhauser C; Golriz AA; Moers C; Klein R; Butt HJ; Frey H
[Ad] Endereço:Institute of Organic Chemistry, Organic and Macromolecular Chemistry, Johannes Gutenberg-University-JGU, Duesbergweg 10-14, 55099 Mainz, Germany.
[Ti] Título:Stimuli-responsive y-shaped polymer brushes based on junction-point-reactive block copolymers.
[So] Source:Adv Mater;24(41):5559-63, 2012 Nov 02.
[Is] ISSN:1521-4095
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Polímeros/química
[Mh] Termos MeSH secundário: Poliestirenos/química
Politetrafluoretileno/química
N-Óxido de Polivinilpiridina/química
Propriedades de Superfície
Temperatura Ambiente
Água/química
Molhabilidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers); 0 (Polystyrenes); 059QF0KO0R (Water); 9002-84-0 (Polytetrafluoroethylene); 9016-06-2 (Polyvinylpyridine N-Oxide)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120818
[St] Status:MEDLINE
[do] DOI:10.1002/adma.201202105


  3 / 108 MEDLINE  
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[PMID]:18604871
[Au] Autor:Beneito-Cambra M; Herrero-Martínez JM; Ramis-Ramos G
[Ad] Endereço:Departament de Química Analítica, Facultat de Química, Universitat de València, Burjassot, Spain.
[Ti] Título:Characterization of poly(4-vinylpyridine 1-oxide) by free-solution capillary electrophoresis and micellar electrokinetic chromatography.
[So] Source:Electrophoresis;29(15):3245-52, 2008 Aug.
[Is] ISSN:0173-0835
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The migration characteristics of poly(4-vinylpyridine 1-oxide) (PVP-NO) in phosphate buffers of acidic pH (20 mM H3PO4 or NaH2PO4) have been studied using both free-solution capillary electrophoresis (FSCE) and MEKC. To inhibit adsorption, 250 mM o-phosphoethanolamine (2-aminoethyl dihydrogen phosphate) was used. In FSCE, PVP-NO showed a narrow peak and a broader band, both having anionic behavior. These peak and band were attributed to the free and aggregated or micellized PVP-NO forms, respectively. According to surface tension measurements, the CMC of SDS in the BGE was 1.8 and 0.48 mM in the absence and in the presence of 1000 microg/mL PVP-NO, respectively, and the association of the polymer with SDS was completed at 9.7 mM SDS. Using MEKC, a narrow peak and a broader band also appeared at SDS concentrations of ca. 1 mM, and their intensity increased with the SDS concentration. These peak and band were attributed to the formation of mixed micelles constituted by both free PVP-NO/SDS and aggregated PVP-NO/SDS, respectively. The determination of PVP-NO by FSCE in commercial additives for laundry was demonstrated.
[Mh] Termos MeSH primário: Cromatografia/métodos
Eletroforese Capilar/métodos
N-Óxido de Polivinilpiridina/análogos & derivados
[Mh] Termos MeSH secundário: Ânions
Tampões (Química)
Detergentes/farmacologia
Lavanderia
Micelas
Organofosfatos
N-Óxido de Polivinilpiridina/análise
Soluções
Tensão Superficial
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (2-aminoethyl phosphate); 0 (Anions); 0 (Buffers); 0 (Detergents); 0 (Micelles); 0 (Organophosphates); 0 (Solutions); 0 (poly(4-vinylpyridine-1-oxide)); 059QF0KO0R (Water); 9016-06-2 (Polyvinylpyridine N-Oxide)
[Em] Mês de entrada:0812
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080708
[St] Status:MEDLINE
[do] DOI:10.1002/elps.200800118


  4 / 108 MEDLINE  
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[PMID]:17125034
[Au] Autor:Idec-Sadkowska I; Andrzejak R; Antonowicz-Juchniewicz J; Kaczmarek-Wdowiak B
[Ad] Endereço:Z Katedry i Kliniki Chorób Wewnetrznych, Zawodowych i Nadcisnienia Tetniczego Akademii Medycznej we Wroclawiu.
[Ti] Título:[Trials of casual treatment of silicosis].
[Ti] Título:Próby leczenia przyczynowego pylicy krzemowej..
[So] Source:Med Pr;57(3):271-80, 2006.
[Is] ISSN:0465-5893
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:Silica-induced lung injury and the development of silicosis is one of the major occupational diseases. Accumulation and deposition of respirable dust containing silica mineral particles in the lung produces chronic lung disease characterized by granulomatous and fibrotic lesions. Knowledge of precise mechanisms, which induce this process is still limited, hence problems faced in the treatment of silicosis, especially the casual one. This article describes various trials of casual silicosis treatment with tetrandrine (Tet), isolated from the root of Stephania tetrandra, tumor necrosis factor (TNF) antagonists, polyvinyl-pyridine-N-oxide (PVNO), aluminum compounds, corticosteroids or bronchoalveolar lavage (BAL). The existing methods are not sufficient, which warrants further investigations. At present, prevention of the disease and treatment of its complications are most important.
[Mh] Termos MeSH primário: Ensaios Clínicos como Assunto/normas
Silicose/terapia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Alcaloides/uso terapêutico
Compostos de Alumínio/uso terapêutico
Benzilisoquinolinas/uso terapêutico
Lavagem Broncoalveolar
Medicamentos de Ervas Chinesas/uso terapêutico
Seres Humanos
Exposição Ocupacional
N-Óxido de Polivinilpiridina/uso terapêutico
Silicose/tratamento farmacológico
Stephania tetrandra
Fator de Necrose Tumoral alfa/antagonistas & inibidores
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Alkaloids); 0 (Aluminum Compounds); 0 (Benzylisoquinolines); 0 (Drugs, Chinese Herbal); 0 (Tumor Necrosis Factor-alpha); 29EX23D5AJ (tetrandrine); 9016-06-2 (Polyvinylpyridine N-Oxide)
[Em] Mês de entrada:0703
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061128
[St] Status:MEDLINE


  5 / 108 MEDLINE  
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[PMID]:16411660
[Au] Autor:Goldstein S; Czapski G; Heller A
[Ad] Endereço:Department of Physical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. sarag@vms.huji.ac.il
[Ti] Título:Mode of action of poly(vinylpyridine-N-oxide) in preventing silicosis: effective scavenging of carbonate anion radical.
[So] Source:Chem Res Toxicol;19(1):86-91, 2006 Jan.
[Is] ISSN:0893-228X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Small particles of crystalline silicon dioxide (crystallites) are exceptionally toxic. Inhalation of quartz crystallites causes silicosis, a devastating lung disease afflicting miners, particularly coal and stone workers. Poly(vinylpyridine-N-oxide)s (PVPNOs) have been applied in the prevention and treatment of silicosis, but their mode of action has been obscure. Recently, the sites of inducible *NO synthase activation and of nitrotyrosine formation were associated anatomically with the pathological quartz particle-caused lesions in the lungs. It has been suggested that the *NO formed combines rapidly with O2*- to yield ONOO-, a potential mediator of lung injury following silica exposure. Here, we show that PVPNOs do not react with peroxynitrite but scavenge exceptionally rapidly CO3*- radicals, which are produced in the decomposition of ONOO- in bicarbonate solutions. The rate constant for the reaction of CO3*- with PVPNO was found to be independent of the type and size of PVPNO, i.e., k = (1.9 +/- 0.2) x 10(5) M(-1) s(-1) per monomer. In contrast, the rate constant for the reaction of CO3*- with the small molecule 4-methylpyridine N-oxide did not exceed 1 x 10(4) M(-1) s(-1). The underlying reason for the difference is that, in the dissolved polymeric PVPNOs, the electrostatic repulsion between the N-oxide zwitterions destabilizes them, increasing dramatically their pKa. The protonated N-oxides at physiological pH have abstractable hydrogen atoms and are expected to react rapidly with CO3*-, just as cyclic hydroxylamines do. It is also shown that PVPNO inhibits tyrosine nitration by peroxynitrite at pH 7.6 in the presence of excess of CO2 in a concentration-dependent manner. Hence, binding of PVPNO to the quartz particles and eliminating CO3*- could prevent the killing of macrophages, the associated release of macrophage-recruiting cytokines, and the amplification of the local concentration of *NO by the recruited macrophages. The latter causes necrosis of the macrophage-infiltrated lung tissue and, upon repair of the necrotic lesion, results in the growth of the dysfunctional fibrotic tissue, which is the hallmark of silicosis.
[Mh] Termos MeSH primário: Bicarbonatos/química
Depuradores de Radicais Livres/química
Radical Hidroxila/química
N-Óxido de Polivinilpiridina/química
Espécies Reativas de Oxigênio/química
[Mh] Termos MeSH secundário: Depuradores de Radicais Livres/uso terapêutico
Seres Humanos
Concentração de Íons de Hidrogênio
Cinética
Ácido Peroxinitroso/química
N-Óxido de Polivinilpiridina/uso terapêutico
Quartzo/química
Silicose/prevenção & controle
Tirosina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Free Radical Scavengers); 0 (Reactive Oxygen Species); 14691-52-2 (Peroxynitrous Acid); 14808-60-7 (Quartz); 3352-57-6 (Hydroxyl Radical); 42HK56048U (Tyrosine); 9016-06-2 (Polyvinylpyridine N-Oxide)
[Em] Mês de entrada:0604
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060118
[St] Status:MEDLINE


  6 / 108 MEDLINE  
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[PMID]:12211632
[Au] Autor:Ernst H; Rittinghausen S; Bartsch W; Creutzenberg O; Dasenbrock C; Görlitz BD; Hecht M; Kairies U; Muhle H; Müller M; Heinrich U; Pott F
[Ad] Endereço:Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany. ernst@ita.fraunhofer.de
[Ti] Título:Pulmonary inflammation in rats after intratracheal instillation of quartz, amorphous SiO2, carbon black, and coal dust and the influence of poly-2-vinylpyridine-N-oxide (PVNO).
[So] Source:Exp Toxicol Pathol;54(2):109-26, 2002 Aug.
[Is] ISSN:0940-2993
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Effects of poly-2-vinylpyridine-N-oxide (PVNO) were investigated in numerous in vivo and in vitro studies published in the nineteen sixties and seventies. These studies showed that PVNO inhibited development of fibrosis from quartz dust and improved lung clearance of quartz after inhalation exposure. Ameliorating effects of PVNO were observed also for pulmonary damage from colloidal SiO2 and organic substances, and the fibrogenic inflammation caused by carrageenan. Although it is not proven that silicosis is a precondition for quartz-induced lung tumours, we investigated the hypothesis that PVNO could reduce the lung tumour risk from quartz in rats. A carcinogenicity study was therefore started in rats with the main focus on the quantitative relationships among pulmonary inflammation, fibrosis and neoplasia caused by intratracheal instillation of 3 mg quartz DQ 12 with or without additional subcutaneous PVNO treatment. Other study groups were treated with multiple dust instillations, i.e. 30 instillations of 0.5 mg amorphous SiO2 at intervals of 2 weeks, 10 instillations of 0.5 mg of ultrafine carbon black or 1 mg coal at weekly intervals. The analyses of the bronchoalveolar lavage fluid (BALF) 9 months after start of the life-time study showed that the aim of producing similar levels of increased enzyme concentrations in the four groups treated with quartz/PVNO, amorphous SiO2, carbon black and coal was achieved. A 2.5- to 7.7-fold increase for lactate dehydrogenase (LDH), total protein, alkaline phosphatase and gamma-glutamyl transferase (gamma-GT) was found in these groups as compared to the control. In contrast, quartz treatment without PVNO increased the LDH level up to 24-fold and of total protein to 13-fold. However, the cell counts in the BALF were not so much different in all five groups, i.e. quartz without PVNO (leukocytes: 480.000, PMN: 190.000), quartz with PVNO (leukocytes: 300.000, PMN: 100.000), amorphous SiO2 (leukocytes: 570.000, PMN: 315.000), carbon black (leukocytes: 390.000, PMN: 150.000) and coal (leukocytes: 200.000, PMN: 65.000). Histopathological investigations after four weeks and three months revealed that the used PVNO sample was active in the quartz and amorphous SiO2 groups and markedly reduced the incidences or severity of several pulmonary changes such as macrophage accumulation, inflammatory cell infiltration, interstitial fibrosis, bronchiolo-alveolar hyperplasia, alveolar lipoproteinosis and amorphous SiO2 -induced granulomatous alveolitis/interstitial fibrotic granulomas. Also in the lung-associated lymph nodes (LALN), PVNO treatment significantly reduced the incidence and severity of inflammation in both quartz and amorphous SiO2 groups as evidenced by the presence of well-circumscribed aggregates of intact particle-laden macrophages without signs of degeneration and accompanying granulocytic infiltration and fibrosis. Immunological investigations at the 9 months timepoint on the in vitro production of reactive nitrogen (RNI) or oxygen (ROI) intermediates and tumour necrosis factor (TNF-alpha) from BALF-derived cells indicated a diminished responsiveness to LPS in all particle treatment groups. A diminished production of ROI was also found in the quartz, carbon black, and coal dust groups, respectively, as compared to the values seen in the quartz/PVNO- and amorphous SiO2 treated groups. Treatment with quartz plus PVNO restored the capability of the cells to respond to LPS as compared to the treatment with quartz alone. TNF-alpha production was diminished in the groups treated with quartz, carbon black, and coal dust alone whereas in the quartz/PVNO- and amorphous SiO2-treated groups an elevated TNF-alpha production was seen. These results led to the conclusion that only amorphous SiO2 did not affect the "normal" ability of the cells to respond to LPS and that PVNO protected the cells from a toxic effect of the quartz particles.
[Mh] Termos MeSH primário: Carbono/efeitos adversos
Inflamação
Neoplasias Pulmonares/etiologia
Neoplasias Pulmonares/prevenção & controle
Pulmão/patologia
N-Óxido de Polivinilpiridina/farmacologia
Quartzo/efeitos adversos
Dióxido de Silício/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/citologia
Carvão Mineral
Poeira
Feminino
Exposição por Inalação
Pulmão/citologia
Pulmão/efeitos dos fármacos
Pulmão/enzimologia
Fibrose Pulmonar/etiologia
Fibrose Pulmonar/patologia
Ratos
Ratos Wistar
Fatores de Risco
Traqueia
Fator de Necrose Tumoral alfa/biossíntese
Fator de Necrose Tumoral alfa/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coal); 0 (Dust); 0 (Tumor Necrosis Factor-alpha); 14808-60-7 (Quartz); 7440-44-0 (Carbon); 7631-86-9 (Silicon Dioxide); 9016-06-2 (Polyvinylpyridine N-Oxide)
[Em] Mês de entrada:0303
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020905
[St] Status:MEDLINE


  7 / 108 MEDLINE  
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[PMID]:12117767
[Au] Autor:Knaapen AM; Albrecht C; Becker A; Höhr D; Winzer A; Haenen GR; Borm PJ; Schins RP
[Ad] Endereço:Institut für umweltmedizinische Forschung at the University of Düsseldorf, Department of Particle Toxicology, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
[Ti] Título:DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation.
[So] Source:Carcinogenesis;23(7):1111-20, 2002 Jul.
[Is] ISSN:0143-3334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Respirable quartz has been classified as a human lung carcinogen (IARC, 1997). However, the mechanisms involved in quartz-induced carcinogenesis remain unclear. The aim of the present study was to investigate acute DNA damage in epithelial lung cells from rats exposed to quartz. Since surface reactivity is considered to play a crucial role in the toxicity of quartz, the effect of surface modifying agents polyvinylpyridine-N-oxide (PVNO) and aluminium lactate (AL) was evaluated. Therefore, rats were instilled with quartz (DQ12, 2 mg/rat) or quartz treated with PVNO or AL. After 3 days animals were killed and brochoalveolar lavage (BAL) was performed to evaluate inflammatory cell influx. BAL-fluid levels of lactate dehydrogenase (LDH), alkaline phosphatase (AP) and total protein were used as lung damage markers. Neutrophil activation was assessed by myeloperoxidase (MPO) measurement, and total antioxidant capacity of the BAL-fluid was determined using the TEAC (trolox equivalent antioxidant capacity) assay. Lung epithelial cells were isolated and DNA strand breakage was determined by single cell gel electrophoresis (comet assay). DNA damage was significantly increased in epithelial cells from rats instilled with DQ12, whereas no enhanced DNA strand breakage was observed when quartz was treated with PVNO or AL. Total protein, LDH and TEAC were increased in rats treated with native quartz, and this was inhibited by both coatings. A significant correlation between neutrophil numbers and MPO levels was observed, indicating neutrophil activation. Inhibition of DNA damage by both coatings was paralleled by a reduction of neutrophil influx as well as MPO activity. In this study we provide evidence that modification of the particle surface prevents DNA strand breakage in epithelial lung cells from quartz-exposed rats. Furthermore, the present data show the feasibility of our in vivo model to evaluate the role of inflammation, antioxidant status, and cytotoxicity in particle-induced DNA damage.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Quartzo/toxicidade
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Compostos de Alumínio/farmacologia
Animais
Antioxidantes/farmacologia
Líquido da Lavagem Broncoalveolar/citologia
Células Cultivadas
Cromanos/farmacologia
Ensaio Cometa
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/enzimologia
Seres Humanos
L-Lactato Desidrogenase/metabolismo
Lactatos/farmacologia
Pulmão/enzimologia
Neutrófilos/fisiologia
N-Óxido de Polivinilpiridina/farmacologia
Ratos
Ratos Wistar
Propriedades de Superfície
Vitamina E/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aluminum Compounds); 0 (Antioxidants); 0 (Chromans); 0 (Lactates); 1406-18-4 (Vitamin E); 14808-60-7 (Quartz); 9016-06-2 (Polyvinylpyridine N-Oxide); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 3.1.3.1 (Alkaline Phosphatase); S18UL9710X (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid); V797H4GG0Z (aluminum lactate)
[Em] Mês de entrada:0208
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020716
[St] Status:MEDLINE


  8 / 108 MEDLINE  
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[PMID]:10682587
[Au] Autor:Liu B; Qin X
[Ad] Endereço:Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China.
[Ti] Título:[Application and analysis of biochemical indices for the evaluation of antisilicosis treatment. Study on anti-silicosis therapy and its evaluation research group].
[So] Source:Wei Sheng Yan Jiu;27(4):222-4, 1998 Jul.
[Is] ISSN:1000-8020
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The levels of serum Ceruloplasmin (Cp), Superoxide dismutase (SOD) and IgG of 296 silicosis patients treated by tetrandrine, polyvinylpridine-N-Oxide, hydroxypiperaquinoline phosphate and aluminium citrate were measured. Sera were collected before and after the 1st, 3rd and 6th therapy courses. 144 Silicosis patients without treatment were observed as controls. The levels of these three indices decreased by the end of treatment. The levels of SOD were fluctuated, which were increased after the 3rd course, but decreased after the 1st and 6th courses. The decrease of Cp, SOD and IgG consisted with the clinical effectiveness of the treatment, indicating that Cp, SOD and IgG were appropriate biochemical indicators for the evaluation of antisilicosis drugs. The quality control and the statistics standardization for data analysis are important.
[Mh] Termos MeSH primário: Alcaloides/uso terapêutico
Benzilisoquinolinas
N-Óxido de Polivinilpiridina/uso terapêutico
Silicose/tratamento farmacológico
Superóxido Dismutase/sangue
[Mh] Termos MeSH secundário: Ceruloplasmina/metabolismo
Quimioterapia Combinada
Seres Humanos
Imunoglobulina G/sangue
Silicose/sangue
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Immunoglobulin G); 29EX23D5AJ (tetrandrine); 9016-06-2 (Polyvinylpyridine N-Oxide); EC 1.15.1.1 (Superoxide Dismutase); EC 1.16.3.1 (Ceruloplasmin)
[Em] Mês de entrada:0004
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000222
[St] Status:MEDLINE


  9 / 108 MEDLINE  
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[PMID]:9303177
[Au] Autor:Syed SS; Hunter RL
[Ad] Endereço:Department of Pathology, Emory University, Atlanta, GA 30322, USA.
[Ti] Título:Studies on the toxic effects of quartz and a mycobacterial glycolipid, trehalose 6,6'-dimycolate.
[So] Source:Ann Clin Lab Sci;27(5):375-83, 1997 Sep-Oct.
[Is] ISSN:0091-7370
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Quartz and trehalose 6,6'-dimycolate (TDM) both potentiate tuberculosis and have toxicities that depend on surface crystalline structures. Investigations were undertaken to determine if TDM can kill macrophages and produce hemolysis in a fashion similar to that of quartz and if quartz can induce granulomas similar to those induced by TDM. Trehalose 6,6'-dimycolate was spread as a molecular monolayer on the surface of tissue culture dishes adjacent to areas of uncoated plastic for comparison. Murine peritoneal macrophages were killed within hours by contact with the TDM monolayer, while those on adjacent areas of uncoated plastic remained viable and spread normally. The membranes of erythrocytes were also damaged by contact with the monolayer of TDM. This damage was inhibited by poly-2-vinyl-pyridine-N-oxide, an inhibitor of hydrogen bonding that blocks quartz induced hemolysis. These data suggest that TDM damages membranes via an adhesive mechanism similar to that of quartz. Furthermore, injections of quartz particles into mice induce acute granulomatous reactions similar to those induced by TDM. These data indicate that TDM and quartz have certain similarities in their mechanisms of action and that these similarities may be of importance in the pathogenesis of tuberculosis.
[Mh] Termos MeSH primário: Fatores Corda/toxicidade
Granuloma/induzido quimicamente
Hemólise
Macrófagos Peritoneais/efeitos dos fármacos
Quartzo/toxicidade
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Doença Hepática Induzida por Substâncias e Drogas
Eritrócitos/efeitos dos fármacos
Feminino
Hemoglobinas/análise
Hepatopatias/patologia
Pneumopatias/induzido quimicamente
Pneumopatias/patologia
Macrófagos Peritoneais/citologia
Camundongos
Mycobacterium tuberculosis/patogenicidade
N-Óxido de Polivinilpiridina/farmacologia
Esplenopatias/induzido quimicamente
Esplenopatias/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cord Factors); 0 (Hemoglobins); 14808-60-7 (Quartz); 9016-06-2 (Polyvinylpyridine N-Oxide)
[Em] Mês de entrada:9801
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970926
[St] Status:MEDLINE


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Fotocópia
[PMID]:8561927
[Au] Autor:Yu L; Zhou CQ; Li YR; Qu L; Xing KJ; Du QC
[Ad] Endereço:Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China.
[Ti] Título:A biochemical study on combined treatment of experimental silicosis with tetradrine-PVNO and tetradrine-QOHP in rats.
[So] Source:Biomed Environ Sci;8(3):265-8, 1995 Sep.
[Is] ISSN:0895-3988
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats.
[Mh] Termos MeSH primário: Alcaloides/uso terapêutico
Benzilisoquinolinas
Piperazinas/uso terapêutico
N-Óxido de Polivinilpiridina/uso terapêutico
Silicose/tratamento farmacológico
[Mh] Termos MeSH secundário: Alcaloides/administração & dosagem
Animais
Dipeptidases/sangue
Masculino
Monoaminoxidase/sangue
Piperazinas/administração & dosagem
Plasminogênio/metabolismo
N-Óxido de Polivinilpiridina/administração & dosagem
Ratos
Ratos Wistar
Silicose/sangue
Silicose/enzimologia
Silicose/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Benzylisoquinolines); 0 (Piperazines); 29EX23D5AJ (tetrandrine); 9001-91-6 (Plasminogen); 9016-06-2 (Polyvinylpyridine N-Oxide); EC 1.4.3.4 (Monoamine Oxidase); EC 3.4.13.- (Dipeptidases); EC 3.4.13.9 (proline dipeptidase)
[Em] Mês de entrada:9603
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950901
[St] Status:MEDLINE



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