Base de dados : MEDLINE
Pesquisa : D02.455.426 [Categoria DeCS]
Referências encontradas : 362 [refinar]
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[PMID]:28554022
[Au] Autor:Liu Y; Yu RC; Kong FZ; Li C; Dai L; Chen ZF; Zhou MJ
[Ad] Endereço:CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR China.
[Ti] Título:Lipophilic marine toxins discovered in the Bohai Sea using high performance liquid chromatography coupled with tandem mass spectrometry.
[So] Source:Chemosphere;183:380-388, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Some dinoflagellates can produce lipophilic marine toxins, which pose potent threats to seafood consumers. In the Bohai Sea, an important semi-closed inland sea with intensive mariculture industry in China, there is little knowledge concerning lipophilic marine toxins and their potential threats. In this study, net-concentrated phytoplankton samples were periodically collected from 5 typical mariculture zones around the Bohai Sea, including Laishan (LS), Laizhou (LZ), Hangu (HG), Qinhuangdao (QHD) and Huludao (HLD) in 2013 and 2014, and a method using high performance liquid chromatography (HPLC) coupled with a Q-Trap mass spectrometer was applied to analyze seven representative lipophilic marine toxins, including okadaic acid (OA), dinophysistoxin-1 (DTX1), pectenotoxin-2 (PTX2), yessotoxin (YTX), azaspiracid-1 (AZA1), gymnodimine (GYM), and 13-desmethyl spirolide C (desMeC). The method had high sensitivity and repeatability, and exhibited satisfactory recoveries for most of the lipophilic marine toxins (92.1-108%) except for AZA1 (65.8-68.9%). Nearly all the lipophilic marine toxins could be detected in phytoplankton samples from the Bohai Sea. OA, DTX1 and PTX2 were predominant components and present in most of the phytoplankton samples. The maximum content of lipophilic marine toxin in phytoplankton samples concentrated from seawater (OA 464 pg L ; DTX1 783 pg L ; YTX 86.6 pg L ; desMeC 15.6 pg L ; PTX2 1.11 × 10 pg L ) appeared in June 2014. Based on toxins present in phytoplankton samples, it is implied that seafood in the Bohai Sea is more likely to be contaminated by OA group and PTX group toxins, and spring is the high-risk season for toxin contamination.
[Mh] Termos MeSH primário: Dinoflagelados/química
Toxinas Marinhas/análise
Fitoplâncton/química
Alimentos Marinhos/normas
[Mh] Termos MeSH secundário: Animais
China
Cromatografia Líquida de Alta Pressão/métodos
Furanos/análise
Compostos Heterocíclicos com 3 Anéis/análise
Hidrocarbonetos Cíclicos/análise
Interações Hidrofóbicas e Hidrofílicas
Iminas/análise
Ácido Okadáico/análise
Oxocinas/análise
Piranos/análise
Alimentos Marinhos/análise
Compostos de Espiro/análise
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (13-desmethylspirolide C); 0 (Furans); 0 (Heterocyclic Compounds, 3-Ring); 0 (Hydrocarbons, Cyclic); 0 (Imines); 0 (Marine Toxins); 0 (Oxocins); 0 (Pyrans); 0 (Spiro Compounds); 0 (azaspiracid); 1W21G5Q4N2 (Okadaic Acid); 4Q51CVY9O2 (dinophysistoxin 1); 7TV3J97IT8 (gymnodimine); 97564-91-5 (pectenotoxin 2); P6M9FM2L2G (yessotoxin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28535464
[Au] Autor:Jiang T; Liu L; Li Y; Zhang J; Tan Z; Wu H; Jiang T; Lu S
[Ad] Endereço:Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; Research Center for Harmful Algae & Marine Biology, Jinan University, Guangzhou 510632, China.
[Ti] Título:Occurrence of marine algal toxins in oyster and phytoplankton samples in Daya Bay, South China Sea.
[So] Source:Chemosphere;183:80-88, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The occurrence and seasonal variations of marine algal toxins in phytoplankton and oyster samples in Daya Bay (DYB), South China Sea were investigated. Two Dinophysis species, namely, D. caudata and D. acuminata complex, were identified as Okadaic acid (OA)/pectenotoxin (PTX) related species. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis demonstrated that 2.04-14.47 pg PTX2 per cell was the predominant toxin in single-cell isolates of D. caudata. D. acuminata was not subjected to toxin analysis. The occurrence of OAs in phytoplankton concentrates of net-haul sample coincided with the presence of D. accuminata complex, suggesting that this species is most likely an OA producer in this sea area. OA, dinophysistoxins-1 (DTX1), PTX2, PTX2sa, gymnodimine (GYM), homoyessotoxin (homoYTX), and domoic acid (DA) demonstrated positive results in net haul samples. To our best knowledge, this paper is the first to report the detection of GYM, DA, and homoYTX in phytoplankton samples in Chinese coastal waters. Among the algal toxins, GYM demonstrated the highest frequency of positive detections in phytoplankton concentrates (13/17). Five compounds of algal toxins, including OA, DTX1, PTX2, PTX2sa, and GYM, were detected in oyster samples. DA and homoYTX were not detected in oysters despite of positive detections for both in the phytoplankton concentrates. However, neither the presence nor absence of DA in oysters can be determined because extraction conditions with 100% methanol used to isolate toxins from oysters (recommended by the EU-Harmonised Standard Operating Procedure, 2015) would likely be unsuitable for this water-soluble toxin. In addition, transformation of DA during the digestion process of oysters may also be involved in the negative detections of this toxin. GYM exhibited the highest frequency of positive results in oysters (14/17). OAs were only detected in the hydrolyzed oyster samples. The detection rates of PTX and PTX2sa in oysters were lower than those in the net haul samples.
[Mh] Termos MeSH primário: Baías/química
Dinoflagelados/metabolismo
Monitoramento Ambiental/métodos
Toxinas Marinhas/análise
Ostreidae/química
Fitoplâncton/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Animais
China
Cromatografia Líquida/métodos
Compostos Heterocíclicos com 3 Anéis/análise
Compostos Heterocíclicos com 3 Anéis/metabolismo
Hidrocarbonetos Cíclicos/análise
Hidrocarbonetos Cíclicos/metabolismo
Iminas/análise
Iminas/metabolismo
Ácido Caínico/análogos & derivados
Ácido Caínico/análise
Ácido Caínico/metabolismo
Toxinas Marinhas/metabolismo
Ácido Okadáico/análise
Ácido Okadáico/metabolismo
Ostreidae/metabolismo
Fitoplâncton/metabolismo
Piranos/análise
Piranos/metabolismo
Espectrometria de Massas em Tandem
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heterocyclic Compounds, 3-Ring); 0 (Hydrocarbons, Cyclic); 0 (Imines); 0 (Marine Toxins); 0 (Pyrans); 0 (Water Pollutants, Chemical); 1W21G5Q4N2 (Okadaic Acid); 4Q51CVY9O2 (dinophysistoxin 1); 7TV3J97IT8 (gymnodimine); M02525818H (domoic acid); SIV03811UC (Kainic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28365503
[Au] Autor:Ukisu Y
[Ad] Endereço:National Institute of Advanced Industrial Science and Technology (AIST), AIST Tsukuba West, 16-1 Onogawa, Tsukuba, Ibaraki, 305-8569, Japan. Electronic address: y-ukisu@aist.go.jp.
[Ti] Título:Complete catalytic debromination of hexabromocyclododecane using a silica-supported palladium catalyst in alkaline 2-propanol.
[So] Source:Chemosphere;179:179-184, 2017 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although the brominated flame retardant 1,2,5,6,9,10-hexabromocyclododecane (HBCD) has been widely used to reduce the flammability of polymeric materials, it is a toxic and persistent organic compound. In this paper, we report an efficient method for the debromination of HBCD by using a Pd-catalyzed system. HBCD was completely debrominated to the C cyclic compounds such as cyclododecatriene, cyclododecadiene, and cyclododecene in a solution of 2-propanol/methanol (99:1, v/v) containing dissolved NaOH in the presence of a silica-supported Pd catalyst (Pd/SiO ) at 35 °C. The reaction achieved product yields of 92% for the bromine-free products and 94% for the released Br ions. In the absence of Pd/SiO , HBCD was partially debrominated to yield penta-, tetra-, and tribrominated C cyclic compounds. The HBCD debromination pathway seems to involve both HBr elimination by reaction with NaOH and Pd-catalyzed hydrodebromination by hydrogen transfer from 2-propanol.
[Mh] Termos MeSH primário: Recuperação e Remediação Ambiental/métodos
Retardadores de Chama
Halogenação
Hidrocarbonetos Bromados/química
Hidrocarbonetos Cíclicos/síntese química
[Mh] Termos MeSH secundário: 2-Propanol
Bromo
Catálise
Hidrogênio/química
Metanol
Paládio/química
Dióxido de Silício
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flame Retardants); 0 (Hydrocarbons, Brominated); 0 (Hydrocarbons, Cyclic); 5I9835JO3M (hexabromocyclododecane); 5TWQ1V240M (Palladium); 7631-86-9 (Silicon Dioxide); 7YNJ3PO35Z (Hydrogen); ND2M416302 (2-Propanol); SBV4XY874G (Bromine); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


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[PMID]:27914609
[Au] Autor:Zhang W; Zhu S; Pang L; Gao X; Zhu GT; Li D
[Ad] Endereço:State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China; State Key Laboratory of Isotope Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
[Ti] Título:Determination of diamondoids in crude oils using gas purge microsyringe extraction with comprehensive two dimensional gas chromatography-time-of-flight mass spectrometry.
[So] Source:J Chromatogr A;1478:75-83, 2016 Dec 23.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Based on a homemade device, gas purge microsyringe extraction (GP-MSE) of crude oil samples was developed for the first time. As a simple, fast, low-cost, sensitive and solvent-saving technique, GP-MSE provides some outstanding advantages over the widely used sample preparation methods for crude oils such as column chromatography (ASTM D2549). Several parameters affecting extraction efficiency were optimized, including extraction temperature, extraction time, extraction solvent, condensing temperature and purge gas flow rate. With the optimized GP-MSE conditions, several real crude oil samples were extracted, and trace diamondoids were determined using comprehensive two dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS). In total, more than 100 diamondoids were detected and 27 marker compounds were identified and quantified accurately. The limits of detection (LODs, S/N=3) were less than 0.08µg/L for all diamondoids. The relative standard deviation (RSD) was below 8%, ranging from 1.1 to 7.6%. The linearity of the developed method was in the range of 0.5-100.0µg/L with correlation coefficients (R ) more than 0.996. The recoveries obtained at spiking 50µg/L were between 81 and 108% for diamondoids in crude oil samples. The developed method can also be extended to the analysis of other components in crude oils and other complex matrices.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Cromatografia Gasosa-Espectrometria de Massas
Hidrocarbonetos Cíclicos/análise
Petróleo/análise
[Mh] Termos MeSH secundário: Gases/química
Limite de Detecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gases); 0 (Hydrocarbons, Cyclic); 0 (Petroleum)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161205
[St] Status:MEDLINE


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[PMID]:27848155
[Au] Autor:Rivera MJ; Rodriguez-Saona C; Alborn HT; Koppenhöfer AM
[Ad] Endereço:Department of Entomology and Nematology, Citrus Research and Education Center, University of Florida, Lake Alfred, FL, USA. monique.rivera@ufl.edu.
[Ti] Título:Differential Response of a Local Population of Entomopathogenic Nematodes to Non-Native Herbivore Induced Plant Volatiles (HIPV) in the Laboratory and Field.
[So] Source:J Chem Ecol;42(12):1259-1264, 2016 Dec.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent work has shown the potential for enhanced efficacy of entomopathogenic nematodes (EPN) through their attraction to herbivore induced plant volatiles. However, there has been little investigation into the utilization of these attractants in systems other than in those in which they were identified. We compared (E)-ß-caryophyllene and pregeijerene in the highbush blueberry (Vaccinium corymbosum) agroecosystem in their ability to enhance the attraction of EPN to and efficacy against the system's herbivore, oriental beetle (Anomala orientalis). The relative attractiveness of (E)-ß-caryophyllene and pregeijerene to a local isolate of the EPN species Steinernema glaseri was tested in a six-arm olfactometer in the laboratory to gather baseline values of attraction to the chemicals alone in sand substrate before field tests. A similar arrangement was used in a V. corymbosum field by placing six cages with assigned treatments and insect larvae with and without compound into the soil around the base of 10 plants. The cages were removed after 72 h, and insect baits were retrieved and assessed for EPN infection. The lab results indicate that in sand alone (E)-ß-caryophyllene is significantly more attractive than pregeijerene to the local S. glaseri isolate Conversely, there was no difference in attractiveness in the field study, but rather, native S. glaseri were more attracted to cages with G. mellonella larvae, no larvae, and cages with the blank control and G. mellonella larvae.
[Mh] Termos MeSH primário: Mirtilos Azuis (Planta)/fisiologia
Coleópteros/fisiologia
Herbivoria
Hidrocarbonetos Cíclicos/metabolismo
Nematoides/fisiologia
Sesquiterpenos/metabolismo
[Mh] Termos MeSH secundário: Animais
Larva/fisiologia
Controle Biológico de Vetores
Olfato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Cyclic); 0 (Sesquiterpenes); 0 (pregeijerene B); BHW853AU9H (caryophyllene)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE


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[PMID]:27147529
[Au] Autor:Overwin H; González M; Méndez V; Seeger M; Wray V; Hofer B
[Ad] Endereço:Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124, Braunschweig, Germany.
[Ti] Título:An aryl dioxygenase shows remarkable double dioxygenation capacity for diverse bis-aryl compounds, provided they are carbocyclic.
[So] Source:Appl Microbiol Biotechnol;100(18):8053-61, 2016 Sep.
[Is] ISSN:1432-0614
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The bacterial dioxygenation of mono- or polycyclic aromatic compounds is an intensely studied field. However, only in a few cases has the repeated dioxygenation of a substrate possessing more than a single aromatic ring been described. We previously characterized the aryl-hydroxylating dioxygenase BphA-B4h, an artificial hybrid of the dioxygenases of the biphenyl degraders Burkholderia xenovorans LB400 and Pseudomonas sp. strain B4-Magdeburg, which contains the active site of the latter enzyme, as an exceptionally powerful biocatalyst. We now show that this dioxygenase possesses a remarkable capacity for the double dioxygenation of various bicyclic aromatic compounds, provided that they are carbocyclic. Two groups of biphenyl analogues were examined: series A compounds containing one heterocyclic aromatic ring and series B compounds containing two homocyclic aromatic rings. Whereas all of the seven partially heterocyclic biphenyl analogues were solely dioxygenated in the homocyclic ring, four of the six carbocyclic bis-aryls were converted into ortho,meta-hydroxylated bis-dihydrodiols. Potential reasons for failure of heterocyclic dioxygenations are discussed. The obtained bis-dihydrodiols may, as we also show here, be enzymatically re-aromatized to yield the corresponding tetraphenols. This opens a way to a range of new polyphenolic products, a class of compounds known to exert multiple biological activities. Several of the obtained compounds are novel molecules.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/metabolismo
Dioxigenases/metabolismo
Hidrocarbonetos Cíclicos/metabolismo
[Mh] Termos MeSH secundário: Oxirredução
Proteínas Recombinantes de Fusão/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Hydrocarbons, Cyclic); 0 (Recombinant Fusion Proteins); EC 1.13.11.- (Dioxygenases)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1007/s00253-016-7570-0


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[PMID]:27032669
[Au] Autor:Savage VJ; Charrier C; Salisbury AM; Moyo E; Forward H; Chaffer-Malam N; Metzger R; Huxley A; Kirk R; Uosis-Martin M; Noonan G; Mohmed S; Best SA; Ratcliffe AJ; Stokes NR
[Ad] Endereço:Redx Pharma, BioHub, Alderley Park, Cheshire SK10 4TG, UK v.savage@redxpharma.com.
[Ti] Título:Biological profiling of novel tricyclic inhibitors of bacterial DNA gyrase and topoisomerase IV.
[So] Source:J Antimicrob Chemother;71(7):1905-13, 2016 Jul.
[Is] ISSN:1460-2091
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this study was to characterize the in vitro and in vivo biological properties of a novel series of small-molecule bacterial type IIA topoisomerase inhibitors. METHODS: Bacterial susceptibility testing was performed by broth microdilution. Resistance frequencies were determined by plating bacteria onto agar containing test compound and enumerating mutants. Bacteria were passaged using subinhibitory concentrations of antibacterials to generate resistance. Target enzyme inhibition was determined by exposure to antibacterials and DNA; topoisomers were visualized by gel electrophoresis. Oral and intravenous pharmacokinetic profiles were determined in mice. In vivo efficacy was determined using a mouse model of septicaemia and thigh infection with MSSA and MRSA, respectively. RESULTS: Representative compounds REDX04139, REDX05604 and REDX05931 demonstrated in vitro potency against a range of Gram-positive and fastidious Gram-negative pathogens. Clinical isolate testing revealed REDX04139 and REDX05931 had MIC90 values of 0.25 and 0.5 mg/L, respectively, for MRSA and MIC90 values of 2 mg/L for streptococci. REDX04139 was bactericidal in vitro against Staphylococcus aureus at 8× MIC over 6 h. Pharmacokinetic profiling of REDX04139 and REDX05604 in mice revealed low clearance and excellent bioavailability (≥71%). REDX04139 provided 100% survival against S. aureus in a mouse septicaemia model, while REDX05604 reduced bacterial load by up to 3.7 log units in the MRSA mouse thigh infection model. CONCLUSIONS: Redx Pharma has discovered a novel series of topoisomerase inhibitors that are being further developed for drug-resistant bacteria.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
DNA Girase/metabolismo
DNA Topoisomerase IV/antagonistas & inibidores
Hidrocarbonetos Cíclicos/farmacologia
Staphylococcus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/isolamento & purificação
Antibacterianos/farmacocinética
Disponibilidade Biológica
Sobrevivência Celular/efeitos dos fármacos
Modelos Animais de Doenças
Células Hep G2
Seres Humanos
Hidrocarbonetos Cíclicos/isolamento & purificação
Hidrocarbonetos Cíclicos/farmacocinética
Masculino
Camundongos
Testes de Sensibilidade Microbiana
Sepse/tratamento farmacológico
Sepse/microbiologia
Infecções Estafilocócicas/tratamento farmacológico
Infecções Estafilocócicas/microbiologia
Streptococcus/efeitos dos fármacos
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hydrocarbons, Cyclic); EC 5.99.1.- (DNA Topoisomerase IV); EC 5.99.1.3 (DNA Gyrase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE
[do] DOI:10.1093/jac/dkw061


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[PMID]:26947902
[Au] Autor:Eruygur N; Yilmaz G; Kutsal O; Yücel G; Üstün O
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Cumhuriyet University, Sivas Center, Sivas 58140, Turkey.
[Ti] Título:Bioassay-guided isolation of wound healing active compounds from Echium species growing in Turkey.
[So] Source:J Ethnopharmacol;185:370-6, 2016 Jun 05.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The roots and root barks of Echium sp. have been used to treat ulcers, burns and wounds in traditional Turkish medicine. AIM OF THE STUDY: On the basis of them traditional use and literature references, four Echium species were selected for evaluation of them wound healing potential. Isolation of active component(s) from the active extracts through the bioassay guided fractionation procedures. MATERIAL AND METHODS: In vivo the wound healing activity of the plants was evaluated by linear incision experimental models. The chloroform extract of Echium italicum L. was fractionated by successive chromatographic techniques. Wound healing activity of each fraction was investigated following the bioassay-guided fractionation procedures. Moreover, the tissue samples of isolated compounds were examined histopathologically. The healing potential was comparatively assessed with a reference ointment Madecassol®, which contains 1% extract of Centella asiatica. RESULTS: Significant wound healing activity was observed from the ointment prepared with ethanol extract at 1% concentration. The ethanol root extract treated in groups of animals showed a significant increase (37.38%, 40.97% and 35.29% separately for E. italicum L, Echium vulgare L. and Echium angustifolium Miller) wound tensile strength in the incision wound model. Subfractions showed significant but reduced wound healing activity on in vivo wound models. Shikonin derivatives "Acetylshikonin", "Deoxyshikonin" and "2-methyl-n-butyrylshikonin+Isovalerylshikonin", were isolated and determined as active components of active final subfraction from E. italicum L. roots. The results of histopathological examination supported the outcome of linear incision wound models. CONCLUSION: The experimental study revealed that Echium species display remarkable wound healing activity.
[Mh] Termos MeSH primário: Echium/química
Hidrocarbonetos Cíclicos/uso terapêutico
Componentes Aéreos da Planta/química
Extratos Vegetais/farmacologia
Cicatrização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Hidrocarbonetos Cíclicos/administração & dosagem
Camundongos
Estrutura Molecular
Extratos Vegetais/química
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Cyclic); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160308
[St] Status:MEDLINE


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[PMID]:26923422
[Au] Autor:Laha JK; Bhimpuria RA; Prajapati DV; Dayal N; Sharma S
[Ad] Endereço:Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research, S. A. S. Nagar, Punjab 160062, India. jlaha@niper.ac.in.
[Ti] Título:Palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes.
[So] Source:Chem Commun (Camb);52(23):4329-32, 2016 Mar 21.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A palladium-catalyzed regioselective C-2 arylation of 7-azaindoles, indoles, and pyrroles with arenes has been developed. This study unveils that a critical substrate dependent acid concentration is essential for achieving exclusive C-2 selectivity as well as mono-arylation in pyrroles. Incongruent to the literature, the protocol uses a reduced volume (at least 5 times) of arenes for workable access to C-2 arylated heterocycles.
[Mh] Termos MeSH primário: Hidrocarbonetos Cíclicos/química
Indóis/química
Paládio/química
Pirróis/química
[Mh] Termos MeSH secundário: Catálise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydrocarbons, Cyclic); 0 (Indoles); 0 (Pyrroles); 5TWQ1V240M (Palladium)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160301
[St] Status:MEDLINE
[do] DOI:10.1039/c6cc00133e


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[PMID]:26856690
[Au] Autor:Vasudev PG; Aravinda S; Shamala N
[Ad] Endereço:Department of Physics, Indian Institute of Science, Bangalore, 560012, India.
[Ti] Título:Crystal structure of a tripeptide containing aminocyclododecane carboxylic acid: a supramolecular twisted parallel ß-sheet in crystals.
[So] Source:J Pept Sci;22(3):166-73, 2016 Mar.
[Is] ISSN:1099-1387
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The crystal structure of a tripeptide Boc-Leu-Val-Ac12 c-OMe (1) is determined, which incorporates a bulky 1-aminocyclododecane-1-carboxylic acid (Ac12 c) side chain. The peptide adopts a semi-extended backbone conformation for Leu and Val residues, while the backbone torsion angles of the C(α,α) -dialkylated residue Ac12 c are in the helical region of the Ramachandran map. The molecular packing of 1 revealed a unique supramolecular twisted parallel ß-sheet coiling into a helical architecture in crystals, with the bulky hydrophobic Ac12 c side chains projecting outward the helical column. This arrangement resembles the packing of peptide helices in crystal structures. Although short oligopeptides often assemble as parallel or anti-parallel ß-sheet in crystals, twisted or helical ß-sheet formation has been observed in a few examples of dipeptide crystal structures. Peptide 1 presents the first example of a tripeptide showing twisted ß-sheet assembly in crystals.
[Mh] Termos MeSH primário: Hidrocarbonetos Cíclicos/química
Oligopeptídeos/química
[Mh] Termos MeSH secundário: Cristalização
Cristalografia por Raios X
Interações Hidrofóbicas e Hidrofílicas
Modelos Moleculares
Oligopeptídeos/síntese química
Estrutura Secundária de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1-aminocyclododecane-1-carboxylic acid); 0 (Hydrocarbons, Cyclic); 0 (Oligopeptides)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160210
[St] Status:MEDLINE
[do] DOI:10.1002/psc.2854



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