Base de dados : MEDLINE
Pesquisa : D02.455.426.392.368.242 [Categoria DeCS]
Referências encontradas : 24 [refinar]
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  1 / 24 MEDLINE  
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[PMID]:28602640
[Au] Autor:Watanabe Y; Hayashida K; Saito D; Takahashi T; Sakai J; Nakata E; Kanda T; Iwai T; Hirayama S; Fujii H; Yamakawa T; Nagase H
[Ad] Endereço:Discovery Research Laboratories, Nippon Chemiphar Co., Ltd, 1-22, Hikokawado, Misato, Saitama 341-0005, Japan.
[Ti] Título:Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration.
[So] Source:Bioorg Med Chem Lett;27(15):3495-3498, 2017 08 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We designed and synthesized novel δ opioid receptor (DOR) agonists 3a-i with an azatricyclodecane skeleton, which was a novel structural class of DOR agonists. Among them, 3b exhibited high values of binding affinity and potent agonistic activity for the DOR that were approximately equivalent to those of 2 which bore an oxazatricyclodecane skeleton. In vitro assays using the blood-brain barrier (BBB) permeability test kit supported the idea that 3b achieved an excellent BBB permeability by converting an oxygen atom of 2 to a carbon atom (methylene group) in the core skeleton. As a result, 3b showed potent antinociceptive effects.
[Mh] Termos MeSH primário: Analgésicos Opioides/farmacologia
Analgésicos Opioides/farmacocinética
Barreira Hematoencefálica/metabolismo
Ciclodecanos/farmacologia
Ciclodecanos/farmacocinética
Receptores Opioides delta/agonistas
[Mh] Termos MeSH secundário: Administração Cutânea
Analgésicos Opioides/síntese química
Analgésicos Opioides/química
Animais
Ciclodecanos/síntese química
Ciclodecanos/química
Desenho de Drogas
Seres Humanos
Camundongos
Receptores Opioides delta/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Cyclodecanes); 0 (Receptors, Opioid, delta)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  2 / 24 MEDLINE  
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[PMID]:28186695
[Au] Autor:Zheng W; Lu Y; Lin S; Wang R; Qiu L; Zhu Y; Yao B; Guo F; Jin S; Jin L; Li Y
[Ad] Endereço:State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, Fujian, 361005, China.
[Ti] Título:A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly.
[So] Source:Chembiochem;18(8):721-725, 2017 Apr 18.
[Is] ISSN:1439-7633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The farnesoid X receptor (FXR) is an important target for drug discovery. Small molecules induce a conformational change in FXR that modulates its binding to co-regulators, thus resulting in distinct FXR functional profiles. However, the mechanisms for selectively recruiting co-regulators by FXR remain elusive, partly because of the lack of FXR-selective modulators. We report the identification of two natural terpenoids, tschimgine and feroline, as novel FXR modulators. Remarkably, their crystal structures uncovered a secondary binding pocket important for ligand binding. Further, tschimgine or feroline induced dynamic conformational changes in the activation function 2 (AF-2) surface, thus leading to differential co-regulator recruiting profiles, modulated by both hydrophobic and selective hydrogen-bond interactions unique to specific co-regulators. Our findings thus provide a novel structure template for optimization for FXR-selective modulators of clinical value.
[Mh] Termos MeSH primário: Compostos Bicíclicos com Pontes/farmacologia
Ciclodecanos/farmacologia
Hidroxibenzoatos/farmacologia
Parabenos/farmacologia
Receptores Citoplasmáticos e Nucleares/agonistas
[Mh] Termos MeSH secundário: Animais
Sítios de Ligação
Haplorrinos
Células Hep G2
Seres Humanos
Interleucina-16/metabolismo
Ligantes
Óxido Nítrico Sintase Tipo II/metabolismo
Mutação Puntual
Estrutura Terciária de Proteína
Receptores Citoplasmáticos e Nucleares/química
Receptores Citoplasmáticos e Nucleares/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bridged Bicyclo Compounds); 0 (Cyclodecanes); 0 (Hydroxybenzoates); 0 (Interleukin-16); 0 (Ligands); 0 (Parabens); 0 (Receptors, Cytoplasmic and Nuclear); 0 (Tumor Necrosis Factor-alpha); 0 (farnesoid X-activated receptor); 0 (feroline); 38970-50-2 (tschimgin); EC 1.14.13.39 (NOS2 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type II)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1002/cbic.201700059


  3 / 24 MEDLINE  
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[PMID]:26118407
[Au] Autor:Chen JP; He W; Yang ZY; Yao ZJ
[Ad] Endereço:State Key Laboratory of Bioorganic and Natural Products Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
[Ti] Título:Synthesis of Tricyclo[4,3,1,0(1,5)]decane Core of Plumisclerin A Using Pauson-Khand Annulation and SmI2-Mediated Radical Cyclization.
[So] Source:Org Lett;17(14):3379-81, 2015 Jul 17.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An efficient synthesis of the tricyclo[4,3,1,0(1, 5)]decane core (B/C/D rings) of plumisclerin A, a unique cytotoxic marine diterpenoid, is described. A Pauson-Khand reaction and a SmI2-mediated radical 1,4-conjugate addition successfully served as key reactions for construction of the fully functionalized 5,6-fused rings and the highly strained cyclobutanol moiety with correct relative stereochemistries, respectively.
[Mh] Termos MeSH primário: Ciclodecanos/síntese química
Diterpenos/síntese química
[Mh] Termos MeSH secundário: Ciclização
Ciclodecanos/química
Diterpenos/química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclodecanes); 0 (Diterpenes); 0 (plumisclerin A)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150718
[Lr] Data última revisão:
150718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150630
[St] Status:MEDLINE
[do] DOI:10.1021/acs.orglett.5b01563


  4 / 24 MEDLINE  
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[PMID]:23923982
[Au] Autor:Rajapaksa NS; Jacobsen EN
[Ad] Endereço:Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
[Ti] Título:Enantioselective catalytic transannular ketone-ene reactions.
[So] Source:Org Lett;15(16):4238-41, 2013 Aug 16.
[Is] ISSN:1523-7052
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Highly enantio- and diastereoselective transannular ketone-ene reactions are catalyzed by a new chromium(III) triflate tridentate Schiff base complex. Electronically unactivated keto-olefins undergo heteroene reactions at ambient temperature to afford enantioenriched bicyclic alcohols, common structural motifs in natural products. The kinetic resolution of a configurationally stable planar-chiral cyclodecenone is also described.
[Mh] Termos MeSH primário: Alcenos/química
Cromo/química
Cetonas/química
Mesilatos/química
Bases de Schiff/química
[Mh] Termos MeSH secundário: Álcoois/química
Catálise
Ciclodecanos/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alcohols); 0 (Alkenes); 0 (Cyclodecanes); 0 (Ketones); 0 (Mesylates); 0 (Schiff Bases); 0R0008Q3JB (Chromium); JE2SY203E8 (trifluoromethanesulfonic acid)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130809
[St] Status:MEDLINE
[do] DOI:10.1021/ol401968m


  5 / 24 MEDLINE  
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[PMID]:23234271
[Au] Autor:Darout E; Robinson RP; McClure KF; Corbett M; Li B; Shavnya A; Andrews MP; Jones CS; Li Q; Minich ML; Mascitti V; Guimarães CR; Munchhof MJ; Bahnck KB; Cai C; Price DA; Liras S; Bonin PD; Cornelius P; Wang R; Bagdasarian V; Sobota CP; Hornby S; Masterson VM; Joseph RM; Kalgutkar AS; Chen Y
[Ad] Endereço:Departments of Medicinal Chemistry, Discovery Biology, Drug Metabolism, and Pharmaceutical Sciences, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA.
[Ti] Título:Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.
[So] Source:J Med Chem;56(1):301-19, 2013 Jan 10.
[Is] ISSN:1520-4804
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A series of GPR119 agonists based on a 2,6-diazatricyclo[3.3.1.1∼3,7∼]decane ring system is described. Also provided is a detailed account of the development of a multigram scale synthesis of the diazatricyclic ring system, which was achieved using a Hofmann-Löffler-Freytag reaction as the key step. The basis for the use of this complex framework lies in an attempt to constrain one end of the molecule in the "agonist conformation" as was previously described for 3-oxa-7-aza-bicyclo[3.3.1]nonanes. Optimization of carbamate analogues of the diazatricylic compounds led to the identification of 32i as a potent agonist of the GPR119 receptor with low unbound human liver microsomal clearance. The use of an agonist response weighted ligand lipophilic efficiency (LLE) termed AgLLE is discussed along with the issues of applying efficiency measures to agonist programs. Ultimately, solubility limited absorption and poor exposure reduced further interest in these molecules.
[Mh] Termos MeSH primário: Compostos Aza/síntese química
Hidrocarbonetos Aromáticos com Pontes/síntese química
Ciclodecanos/síntese química
Receptores Acoplados a Proteínas-G/agonistas
[Mh] Termos MeSH secundário: Animais
Compostos Aza/química
Compostos Aza/farmacologia
Disponibilidade Biológica
Hidrocarbonetos Aromáticos com Pontes/química
Hidrocarbonetos Aromáticos com Pontes/farmacologia
Cristalografia por Raios X
Ciclodecanos/química
Ciclodecanos/farmacologia
Cães
Desenho de Drogas
Seres Humanos
Masculino
Microssomos Hepáticos/metabolismo
Estrutura Molecular
Pirimidinas/síntese química
Pirimidinas/química
Pirimidinas/farmacologia
Ratos
Ratos Sprague-Dawley
Receptores Acoplados a Proteínas-G/química
Solubilidade
Estereoisomerismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aza Compounds); 0 (Bridged-Ring Compounds); 0 (Cyclodecanes); 0 (GPR119 protein, human); 0 (Pyrimidines); 0 (Receptors, G-Protein-Coupled)
[Em] Mês de entrada:1304
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121214
[St] Status:MEDLINE
[do] DOI:10.1021/jm301626p


  6 / 24 MEDLINE  
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[PMID]:22552591
[Au] Autor:Frauscher KE; Ilie N
[Ad] Endereço:Department of Restorative Dentistry, Dental School of Ludwig-Maximilians-University, Goethestr. 70, 80336 Munich, Germany.
[Ti] Título:Degree of conversion of nano-hybrid resin-based composites with novel and conventional matrix formulation.
[So] Source:Clin Oral Investig;17(2):635-42, 2013 Mar.
[Is] ISSN:1436-3771
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: This study aimed to determine the degree of conversion (DC) of two nano-hybrid resin-based composites (RBCs) with novel monomer composition based on dimer acid derivates (hydrogenated dimer acid) and tricyclodecane-urethane structure compared to three nano-hybrid materials containing conventional matrices. DC was evaluated at 0.1, 2, and 6 mm depth at varying irradiation times (10, 20, and 40 s) and layering techniques (bulk and incremental). MATERIALS AND METHODS: DC was measured in real time by a Fourier transform infrared spectroscopy (FTIR) spectrometer with attenuated total reflectance accessory. The FTIR spectra were recorded on the bottom of the samples in real time for 5 min from photoinitiation. Results were compared using one- and multiple-way ANOVA, Tukey's HSD post hoc test (α = 0.05), and partial eta-squared statistic. RESULTS: After 5 min of measurement, DC showed no significant difference by varying cure time for specimens of 0.1 mm thickness. At 2 mm depth, the DC significantly increased after a cure time of 20 s compared to 10 s, remaining equal after 40 s of irradiation. At 6 mm depth, bulk curing showed significantly lower DC compared to incremental curing for all polymerization times. Specimen geometry revealed a strong effect on DC (η (2) = 0.90) followed by curing time (η (2) = 0.39). CONCLUSIONS: The RBCs containing the dimer acid and tricyclodecane-urethane structure showed a relatively low decrease of DC with increasing incremental thickness compared to the conventionally formulated materials. The former reached the highest DC among the tested materials. CLINICAL RELEVANCE: For the tested RBCs, increments of 2 mm and irradiation time of at least 20 s may be recommended for clinical practice. The two materials containing novel monomer composition might be applied for enlarged increments because of the low decrease of DC they demonstrated for 6-mm increments.
[Mh] Termos MeSH primário: Resinas Compostas/química
Materiais Dentários/química
Nanocompostos/química
[Mh] Termos MeSH secundário: Bis-Fenol A-Glicidil Metacrilato/química
Química Farmacêutica
Resinas Compostas/efeitos da radiação
Ciclodecanos/química
Ciclodecanos/efeitos da radiação
Materiais Dentários/efeitos da radiação
Seres Humanos
Hidrogenação
Teste de Materiais
Metacrilatos/química
Metacrilatos/efeitos da radiação
Nanocompostos/efeitos da radiação
Polietilenoglicóis/química
Polimerização
Ácidos Polimetacrílicos/química
Poliuretanos/química
Poliuretanos/efeitos da radiação
Espectroscopia de Infravermelho com Transformada de Fourier
Propriedades de Superfície
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Composite Resins); 0 (Cyclodecanes); 0 (Dental Materials); 0 (Methacrylates); 0 (N'Durance composite resin); 0 (Polymethacrylic Acids); 0 (Polyurethanes); 0 (Simile composite resin); 0 (premise composite resin); 125523-74-2 (urethane dimethacrylate luting resin); 14I47YJ5EY (triethylene glycol dimethacrylate); 30IQX730WE (Polyethylene Glycols); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:120504
[St] Status:MEDLINE
[do] DOI:10.1007/s00784-012-0736-y


  7 / 24 MEDLINE  
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[PMID]:22548364
[Au] Autor:Pu X; Li G; Yang T; Li G; Yi J; Zhang G; Luo Y
[Ad] Endereço:Center for Natural Products Research , Chengdu Institute of Biology of the Chinese Academy of Sciences, Chengdu, People's Republic of China.
[Ti] Título:A new cyclododeca[d]oxazole derivative from Streptomyces spp. CIBYL1.
[So] Source:Nat Prod Res;27(7):603-8, 2013 Apr.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel secondary metabolite, N-trans-cinnamoyl 2-amino-3a,4,5,6,7,8,9,10,11,12,13,13a-dodecahydrocyclododeca[d]oxazole (1), was isolated from Streptomyces spp. CIBYL1, along with five known compounds, pimprinine (2), (3R,4S,5R,6R)-3,4,5,6-tetrahydro-4-hydroxy-3,5,6-trimethyl-2H-pyran-2-one (3), indolyl-3-carboxylic acid (4), 2-phenylacetamide (5) and di(1H-pyrrol-2-yl)methanone (6). The structures of these metabolites were elucidated on the basis of extensive analysis of spectroscopic data, including OR, IR, HRMS, 1D and 2D NMR data and chemical derivation.
[Mh] Termos MeSH primário: Oxazóis/química
Streptomyces/química
[Mh] Termos MeSH secundário: Ciclodecanos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclodecanes); 0 (Oxazoles)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:130408
[Lr] Data última revisão:
130408
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120503
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2012.682997


  8 / 24 MEDLINE  
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[PMID]:22411263
[Au] Autor:Schmidt C; Ilie N
[Ad] Endereço:Department of Restorative Dentistry, Dental School of the Ludwig-Maximilians-University, Goethestr. 70, 80336, Munich, Germany.
[Ti] Título:The effect of aging on the mechanical properties of nanohybrid composites based on new monomer formulations.
[So] Source:Clin Oral Investig;17(1):251-7, 2013 Jan.
[Is] ISSN:1436-3771
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Nanohybrid resin-based composites (RBCs) containing new types of matrix monomers such as dimer acid-based dimethacrylate or tricyclodecane-urethane are assumed to show decreased water uptake and therefore better resistance to hydrolytic degradation than RBCs using bisphenol A diglycidyl methacrylate (BisGMA) due to their hydropobic nature. Our study aimed to analyze the effect of aging on six nanohybrid RBCs, of which two are using these new types of monomers, with regard to differences in the mechanical properties of the materials. MATERIALS AND METHODS: Diametral tensile strength (DTS), Vickers hardness (HV), and creep were measured. Mechanical tests were performed after storing samples for 24 h in distilled water, as well as after aging (thermocycling for 5,000 cycles at 5-55°C and storage for 4 weeks either in distilled water, artificial saliva, or ethanol). RESULTS: The effect of aging on all test parameters was lower than the effect of the material. This information was provided by a general linear model, showing higher partial η(2) values for the influence factor material than for the factor aging. The influence of aging on the micromechanical properties HV and creep was proven to be more sensitive than on the macromechanical property (DTS). This was also illustrated by lower η(2) values for the variable aging for DTS. An increase of the creep of all materials was observed after storage in alcohol. CONCLUSIONS: The use of new types of monomers could not be shown to be a significant advantage to the other examined materials containing BisGMA. CLINICAL RELEVANCE: Nanohybrid composites can be recommended as universal filling materials, whether based on new or conventional monomers.
[Mh] Termos MeSH primário: Resinas Compostas/química
Materiais Dentários/química
Nanocompostos/química
[Mh] Termos MeSH secundário: Bis-Fenol A-Glicidil Metacrilato/química
Ácidos Carboxílicos/química
Química Farmacêutica
Ciclodecanos/química
Etanol/química
Dureza
Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Teste de Materiais
Fenômenos Mecânicos
Metacrilatos/química
Saliva Artificial/química
Solventes/química
Estresse Mecânico
Propriedades de Superfície
Temperatura Ambiente
Resistência à Tração
Fatores de Tempo
Uretana/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carboxylic Acids); 0 (Composite Resins); 0 (Cyclodecanes); 0 (Dental Materials); 0 (Grandio); 0 (Methacrylates); 0 (N'Durance composite resin); 0 (Saliva, Artificial); 0 (Simile composite resin); 0 (Solvents); 0 (Venus (composite resin)); 0 (premise composite resin); 059QF0KO0R (Water); 3IN71E75Z5 (Urethane); 3K9958V90M (Ethanol); 454I75YXY0 (Bisphenol A-Glycidyl Methacrylate)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:120314
[St] Status:MEDLINE
[do] DOI:10.1007/s00784-012-0707-3


  9 / 24 MEDLINE  
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[PMID]:22971012
[Au] Autor:Aschmann SM; Arey J; Atkinson R
[Ad] Endereço:Air Pollution Research Center, University of California, Riverside, California 92521, USA.
[Ti] Título:Kinetics and products of the reactions of OH radicals with cyclohexene, 1-methyl-1-cyclohexene, cis-cyclooctene, and cis-cyclodecene.
[So] Source:J Phys Chem A;116(38):9507-15, 2012 Sep 27.
[Is] ISSN:1520-5215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rate constants for the reactions of OH radicals with four C(6)-C(10) cycloalkenes have been measured at 297 ± 2 K using a relative rate technique. The rate constants (in units of 10(-11) cm(3) molecule(-1) s(-1)) were cyclohexene, 6.35 ± 0.12; cis-cyclooctene, 5.16 ± 0.15; cis-cyclodecene, 4.18 ± 0.06; and 1-methyl-1-cyclohexene, 9.81 ± 0.18, where the indicated errors are two least-squares standard deviations and do not include uncertainties in the rate constant for the reference compound 1,3,5-trimethylbenzene. In addition, a rate constant of (4.8 ± 1.3) × 10(-11) cm(3) molecule(-1) s(-1) was derived for the reaction of OH radicals with 1,6-hexanedial, relative to our measured rate constant for OH + cyclohexene. Analyses of products of the OH + cyclohexene, 1-methyl-1-cyclohexene, and cis-cyclooctene reactions by direct air sampling atmospheric pressure ionization mass spectrometry and/or by combined gas chromatography-mass spectrometry showed the presence of products attributed to cyclic 1,2-hydroxynitrates and the dicarbonyls 1,6-hexanedial, 6-oxo-heptanal, and 1,8-octanedial, respectively. These dicarbonyl products, which are those formed after decomposition of the intermediate cyclic 1,2-hydroxyalkoxy radicals, were quantified as their dioximes, with molar formation yields of 76 ± 10%, 82 ± 12%, and 84 ± 18% from the cyclohexene, 1-methyl-1-cyclohexene, and cis-cyclooctene reactions, respectively. Combined with literature data concerning 1,2-hydroxynitrate formation from OH + alkenes and the estimated fractions of the overall reactions proceeding by H-atom abstraction, 90 ± 12%, 95 ± 13% and 108 ± 20% of the products or reaction pathways from the OH radical-initiated reactions of cyclohexene, 1-methyl-1-cyclohexene, and cis-cyclooctene in the presence of NO are accounted for.
[Mh] Termos MeSH primário: Ciclodecanos/química
Cicloexenos/química
Ciclo-Octanos/química
Radical Hidroxila/química
[Mh] Termos MeSH secundário: Cinética
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Cyclodecanes); 0 (Cyclohexenes); 0 (Cyclooctanes); 3352-57-6 (Hydroxyl Radical)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:120927
[Lr] Data última revisão:
120927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120914
[St] Status:MEDLINE


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[PMID]:21082189
[Au] Autor:Vernez D; Wognin B; Tomicic C; Plateel G; Charrière N; Bruhin S
[Ad] Endereço:Institute of Work and Health, Lausanne, Switzerland. David.vernez@hospvd.ch
[Ti] Título:Cyclododecane exposure in the field of conservation and restoration of art objects.
[So] Source:Int Arch Occup Environ Health;84(4):371-4, 2011 Apr.
[Is] ISSN:1432-1246
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Recent work practices in the conservation and restoration involve the use of cyclododecane (CDD, CAS 294-62-2) to protect fragile artifacts during their handling or transportation. Little is known about its toxicity, and no previous exposure has been reported. A short field investigation was conducted to characterize the exposure conditions to both CDD vapors and aerosols. METHODS: Measurements were conducted in the laboratory of conservation and restoration of the archeological service in Bern (Switzerland). Three indoor and four outdoor typical work situations, either during brush or spray gun applications, were investigated. Measurements were performed on charcoal adsorbent tube and analyzed by a gas chromatograph equipped with a flame ionization detector. RESULTS: Measurements have been conducted during both brush and spray gun applications. Indoor exposures were of 0.75-15.5 mg/m(3), while outdoors exposures were 19.5-53.9 mg/m(3). Exposures appear to be extremely localized due to both physicochemical properties and application methods of the CDD. Vapor exposure increases dramatically with the confinement of the workplace. CONCLUSION: Preventive measures should be undertaken to limit as much as possible these exposures. Field work in confined areas (ditches, underground) is of particular concern. CDD-coated artifacts or materials should be stored in ventilated areas to avoid delayed exposures.
[Mh] Termos MeSH primário: Poluentes Ocupacionais do Ar/análise
Poluição do Ar em Ambientes Fechados/análise
Arte
Ciclodecanos/análise
Exposição Ocupacional/análise
[Mh] Termos MeSH secundário: Poluentes Ocupacionais do Ar/toxicidade
Ciclodecanos/toxicidade
Monitoramento Ambiental
Seres Humanos
Exposição por Inalação/análise
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Exposição Ocupacional/efeitos adversos
Volatilização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants, Occupational); 0 (Cyclodecanes)
[Em] Mês de entrada:1107
[Cu] Atualização por classe:110316
[Lr] Data última revisão:
110316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101118
[St] Status:MEDLINE
[do] DOI:10.1007/s00420-010-0596-1



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