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[PMID]:29053947
[Au] Autor:Munger SD
[Ad] Endereço:Center for Smell and Taste, University of Florida, Gainesville, FL 32610, USA; Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Florida, Gainesville, FL 32610, USA. Electronic address: steven.munger@ufl.edu.
[Ti] Título:A Bitter Tale of Sweet Synergy.
[So] Source:Cell Chem Biol;24(10):1191-1192, 2017 Oct 19.
[Is] ISSN:2451-9456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Some sweeteners show a synergistic enhancement of perceived sweetness when they are tasted as binary mixtures. In this issue of Cell Chemical Biology, Behrens et al. (2017) find that a surprising explanation for this classic observation may lie in their reciprocal inhibition of bitter taste receptors.
[Mh] Termos MeSH primário: Edulcorantes/farmacologia
Percepção Gustatória/efeitos dos fármacos
[Mh] Termos MeSH secundário: Ciclamatos/farmacologia
Sinergismo Farmacológico
Sacarina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclamates); 0 (Sweetening Agents); FST467XS7D (Saccharin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE


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[PMID]:28919036
[Au] Autor:Behrens M; Blank K; Meyerhof W
[Ad] Endereço:German Institute of Human Nutrition Potsdam-Rehbruecke, Department Molecular Genetics, 14558 Nuthetal, Germany. Electronic address: behrens@dife.de.
[Ti] Título:Blends of Non-caloric Sweeteners Saccharin and Cyclamate Show Reduced Off-Taste due to TAS2R Bitter Receptor Inhibition.
[So] Source:Cell Chem Biol;24(10):1199-1204.e2, 2017 Oct 19.
[Is] ISSN:2451-9456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Non-caloric sweeteners are widely used for the formulation of calorie-reduced beverages for health-conscious consumers. However, disadvantages such as undesired off-tastes limit the use of non-nutritive sweeteners. Therefore, the food industry is constantly searching for novel sweeteners and frequently resorts to using blends combining non-caloric sweeteners in a single formulation. The earliest blend allowing higher sweetness levels with reduced bitter off-taste combined saccharin with cyclamate. However, the mechanism by which sweetener blends become superior to single compounds remained obscure. By functional expression of human bitter taste receptors, we found the explanation for the phenomenon observed ∼60 years ago. We demonstrate that cyclamate potently blocks the receptors responsible for saccharin's bitter off-taste. This effect occurs at concentrations where cyclamate itself does not elicit a side taste. Intriguingly, also saccharin inhibits cyclamate-activated bitter receptors. Our experiments demonstrate that heterologous assays are useful for understanding perceptual phenomena and the development of novel tastant formulations.
[Mh] Termos MeSH primário: Ciclamatos/farmacologia
Adoçantes não Calóricos/farmacologia
Receptores Acoplados a Proteínas-G/antagonistas & inibidores
Sacarina/farmacologia
Percepção Gustatória/efeitos dos fármacos
[Mh] Termos MeSH secundário: Interações Medicamentosas
Células HEK293
Seres Humanos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclamates); 0 (Non-Nutritive Sweeteners); 0 (Receptors, G-Protein-Coupled); FST467XS7D (Saccharin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE


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[PMID]:28700634
[Au] Autor:Alvarado C; Nachtigal D; Slack JP; Green BG
[Ad] Endereço:The John B. Pierce Laboratory, New Haven, Connecticut, United States of America.
[Ti] Título:Differential modulation of the lactisole 'Sweet Water Taste' by sweeteners.
[So] Source:PLoS One;12(7):e0180787, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pre-exposure to taste stimuli and certain chemicals can cause water to have a taste. Here we studied further the 'sweet water taste' (SWT) perceived after exposure to the sweet taste inhibitor lactisole. Experiment 1 investigated an incidental observation that presenting lactisole in mixture with sucrose reduced the intensity of the SWT. The results confirmed this observation and also showed that rinsing with sucrose after lactisole could completely eliminate the SWT. The generalizability of these findings was investigated in experiment 2 by presenting 5 additional sweeteners before, during, or after exposure to lactisole. The results found with sucrose were replicated with fructose and cyclamate, but the 3 other sweeteners were less effective suppressors of the SWT, and the 2 sweeteners having the highest potency initially enhanced it. A third experiment investigated these interactions on the tongue tip and found that the lactisole SWT was perceived only when water was actively flowed across the tongue. The same experiment yielded evidence against the possibility that suppression of the SWT following exposure to sweeteners is an aftereffect of receptor activation while providing additional support for a role of sweetener potency. Collectively these results provide new evidence that complex inhibitory and excitatory interactions occur between lactisole and agonists of the sweet taste receptor TAS1R2-TAS1R3. Receptor mechanisms that may be responsible for these interactions are discussed in the context of the current model of the SWT and the possible contribution of allosteric modulation.
[Mh] Termos MeSH primário: Edulcorantes/farmacologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Derivados de Benzeno/farmacologia
Ciclamatos/farmacologia
Feminino
Frutose/farmacologia
Seres Humanos
Masculino
Meia-Idade
Receptores Acoplados a Proteínas-G/metabolismo
Sacarose/farmacologia
Percepção Gustatória/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Benzene Derivatives); 0 (Cyclamates); 0 (Receptors, G-Protein-Coupled); 0 (Sweetening Agents); 0 (taste receptors, type 1); 30237-26-4 (Fructose); 57-50-1 (Sucrose); ZU3D90W5GZ (lactisole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180787


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[PMID]:28506059
[Au] Autor:Logue C; Dowey LRC; Strain JJ; Verhagen H; McClean S; Gallagher AM
[Ad] Endereço:Nutrition Innovation Centre for Food and Health (NICHE), Ulster University , Coleraine, Northern Ireland BT52 1SA.
[Ti] Título:Application of Liquid Chromatography-Tandem Mass Spectrometry To Determine Urinary Concentrations of Five Commonly Used Low-Calorie Sweeteners: A Novel Biomarker Approach for Assessing Recent Intakes?
[So] Source:J Agric Food Chem;65(22):4516-4525, 2017 Jun 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although the use of low-calorie sweeteners (LCSs) is widespread, methods of assessing consumption within free-living populations have inherent limitations. Five commonly consumed LCSs, namely, acesulfame-K, saccharin, sucralose, cyclamate, and steviol glycosides, are excreted via the urine, and therefore a urinary biomarker approach may provide more objective LCS intake data. A LC-ESI-MS/MS method of simultaneously determining acesulfame-K, saccharin, sucralose, cyclamate, and the excretory metabolite of steviol glycosides, steviol glucuronide, in human urine was developed and validated. Linearity was observed over a concentration range of 10-1000 ng/mL with coefficients of determination ranging from 0.9969 to 0.9997. Accuracy ranged from 92 to 104%, and intrabatch and interday precisions were within acceptable limits with %CV below 8% for all compounds. A double-blind, randomized crossover dose-response study was conducted to assess the usefulness of urinary LCS excretions (from both fasting spot and a full 24-h urine collection) for investigating recent intakes. Both modes of sampling were useful for distinguishing between the three short-term intakes of acesulfame-K, saccharin, cyclamates, and steviol glycosides (p < 0.001), whereas for sucralose, urinary concentrations were useful for distinguishing between low (0.1% ADI) and high doses (10% ADI) only (p < 0.001). In summary, this biomarker approach may be useful for assessing intakes of five commonly consumed LCSs.
[Mh] Termos MeSH primário: Biomarcadores/urina
Cromatografia Líquida de Alta Pressão/métodos
Edulcorantes/análise
Espectrometria de Massas em Tandem/métodos
Urina/química
[Mh] Termos MeSH secundário: Biomarcadores/metabolismo
Ciclamatos/análise
Ciclamatos/metabolismo
Diterpenos Caurânicos/metabolismo
Diterpenos Caurânicos/urina
Seres Humanos
Sacarina/análise
Sacarina/metabolismo
Sacarose/análogos & derivados
Sacarose/análise
Sacarose/metabolismo
Sacarose/urina
Edulcorantes/metabolismo
Tiazinas/metabolismo
Tiazinas/urina
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cyclamates); 0 (Diterpenes, Kaurane); 0 (Sweetening Agents); 0 (Thiazines); 4741LYX6RT (steviol); 57-50-1 (Sucrose); 96K6UQ3ZD4 (trichlorosucrose); FST467XS7D (Saccharin); MA3UYZ6K1H (acetosulfame)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00404


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[PMID]:28395647
[Au] Autor:Sargaço B; Serra C; Vasco E
[Ad] Endereço:a Chemical Engineering and Biotechnology Research Center, Chemical Engineering Department , High Institute of Engineering of Lisbon , Lisbon , Portugal.
[Ti] Título:Validation of an HPLC-DAD/UV method for the quantification of cyclamate in tabletop sweeteners: risk of exceeding the acceptable daily intake.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;34(6):883-890, 2017 Jun.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cyclamate is widely used as intense sweetener in the European Union. The absence of a maximum limit for the use of cyclamate in tabletop sweeteners and the growing demand for this type of product highlights the importance of developing robust analytical methods for the determination of its content to understand if the consumption of tabletop sweeteners can have a negative impact on human health. The present work aimed at the optimisation and validation of an high-performance liquid chromatography (HPLC) analytical method for cyclamate determination in tabletop sweeteners based on the procedure of European Standard EN 12857. The validated method was then applied to the determination of this sweetener in different types of tabletop sweeteners (liquid, powder and tablets). Both standards and samples solutions were submitted to a derivatisation procedure which converted cyclamate to N,N-dichlorocyclohexylamine. The derivatised product was separated and quantified using a reversed-phase column, a mobile phase composed of water (20%) and methanol (80%), isocratic flow of 1 ml min , and detection by ultraviolet spectrophotometry at a wavelength of 314 nm. The analytical method was internally validated according to the following validation parameters: working range, linearity, limits of detection and quantification, sensitivity, precision (repeatability and intermediate precision), and uncertainty. This method proved to be specific and selective for the determination of this sweetener, showing repeatability, RSD ≤ 3%, intermediate precision, RSD ≤ 3.3%, and recovery rates from 92% to 108% for the different tabletop sweeteners. The method uncertainty was 9.4%. The concentration of cyclamate in the samples varied significantly, from 2.9% to 73.9%, which demonstrated that a possible excessive consumption of one of the analysed sweeteners can lead to exceeding the acceptable daily intake for cyclamate.
[Mh] Termos MeSH primário: Ciclamatos/análise
Dieta
Edulcorantes/química
Raios Ultravioleta
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Seres Humanos
Recomendações Nutricionais
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Cyclamates); 0 (Sweetening Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170412
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2017.1306756


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[PMID]:27383923
[Au] Autor:Zhang T; Gan Z; Gao C; Ma L; Li Y; Li X; Sun H
[Ad] Endereço:School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-Sen University, 135 Xingang West Street, Guangzhou 510275, PR China. zhangt47@mail.sysu.edu.cn.
[Ti] Título:Occurrence of artificial sweeteners in human liver and paired blood and urine samples from adults in Tianjin, China and their implications for human exposure.
[So] Source:Environ Sci Process Impacts;18(9):1169-76, 2016 Sep 14.
[Is] ISSN:2050-7895
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, acesulfame (ACE), saccharin (SAC) and cyclamate (CYC) were found in all paired urine and blood samples collected from healthy adults, with mean values of 4070, 918 and 628 ng mL(-1), respectively, in urine and 9.03, 20.4 and 0.72 ng mL(-1), respectively, in blood. SAC (mean: 84.4 ng g(-1)) and CYC (4.29 ng g(-1)) were detectable in all liver samples collected from liver cancer patients, while ACE was less frequently detected. Aspartame (ASP) was not found in any analyzed human sample, which can be explained by the fact that this chemical metabolized rapidly in the human body. Among all adults, significantly positive correlations between SAC and CYC levels were observed (p < 0.001), regardless of human matrices. Nevertheless, no significant correlations between concentrations of SAC (or CYC) and ACE were found in any of the human matrices. Our results suggest that human exposure to SAC and CYC is related, whereas ACE originates from a discrete source. Females (or young adults) were exposed to higher levels of SAC and CYC than males (or elderly). The mean renal clearance of SAC was 730 mL per day per kg in adults, which was significantly (p < 0.001) lower than those for CYC (10 800 mL per day per kg) and ACE (10 300 mL per day per kg). The average total daily intake of SAC and ACE was 9.27 and 33.8 µg per kg bw per day, respectively.
[Mh] Termos MeSH primário: Exposição Ambiental/análise
Fígado/metabolismo
Edulcorantes/farmacocinética
[Mh] Termos MeSH secundário: Adulto
Aspartame/análise
Aspartame/metabolismo
Aspartame/farmacocinética
China
Ciclamatos/análise
Ciclamatos/metabolismo
Ciclamatos/farmacocinética
Feminino
Seres Humanos
Masculino
Taxa de Depuração Metabólica
Meia-Idade
Sacarina/análise
Sacarina/metabolismo
Sacarina/farmacocinética
Edulcorantes/análise
Edulcorantes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclamates); 0 (Sweetening Agents); FST467XS7D (Saccharin); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1039/c6em00130k


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[PMID]:27023816
[Au] Autor:Perkola N; Vaalgamaa S; Jernberg J; Vähätalo AV
[Ad] Endereço:Finnish Environment Institute (SYKE), Laboratory Centre, Hakuninmaantie 6, FI-00430, Helsinki, Finland. noora.perkola@environment.fi.
[Ti] Título:Degradation of artificial sweeteners via direct and indirect photochemical reactions.
[So] Source:Environ Sci Pollut Res Int;23(13):13288-97, 2016 Jul.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We studied the direct and indirect photochemical reactivity of artificial sweeteners acesulfame, saccharin, cyclamic acid and sucralose in environm entally relevant dilute aqueous solutions. Aqueous solutions of sweeteners were irradiated with simulated solar radiation (>290 nm; 96 and 168 h) or ultraviolet radiation (UVR; up to 24 h) for assessing photochemical reactions in surface waters or in water treatment, respectively. The sweeteners were dissolved in deionised water for examination of direct photochemical reactions. Direct photochemical reactions degraded all sweeteners under UVR but only acesulfame under simulated solar radiation. Acesulfame was degraded over three orders of magnitude faster than the other sweeteners. For examining indirect photochemical reactions, the sweeteners were dissolved in surface waters with indigenous dissolved organic matter or irradiated with aqueous solutions of nitrate (1 mg N/L) and ferric iron (2.8 mg Fe/L) introduced as sensitizers. Iron enhanced the photodegradation rates but nitrate and dissolved organic matter did not. UVR transformed acesulfame into at least three products: iso-acesulfame, hydroxylated acesulfame and hydroxypropanyl sulfate. Photolytic half-life was one year for acesulfame and more than several years for the other sweeteners in surface waters under solar radiation. Our study shows that the photochemical reactivity of commonly used artificial sweeteners is variable: acesulfame may be sensitive to photodegradation in surface waters, while saccharin, cyclamic acid and sucralose degrade very slowly even under the energetic UVR commonly used in water treatment.
[Mh] Termos MeSH primário: Edulcorantes/efeitos da radiação
Raios Ultravioleta
Poluentes Químicos da Água/efeitos da radiação
[Mh] Termos MeSH secundário: Ciclamatos/química
Ciclamatos/efeitos da radiação
Meia-Vida
Fotólise
Sacarina/química
Sacarina/efeitos da radiação
Sacarose/análogos & derivados
Sacarose/química
Sacarose/efeitos da radiação
Edulcorantes/química
Tiazinas/química
Tiazinas/efeitos da radiação
Poluentes Químicos da Água/química
Purificação da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclamates); 0 (Sweetening Agents); 0 (Thiazines); 0 (Water Pollutants, Chemical); 57-50-1 (Sucrose); 96K6UQ3ZD4 (trichlorosucrose); FST467XS7D (Saccharin); MA3UYZ6K1H (acetosulfame)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-6489-4


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[PMID]:26795541
[Au] Autor:Zirlewagen J; Licha T; Schiperski F; Nödler K; Scheytt T
[Ad] Endereço:Technische Universität Berlin, Dept. of Applied Geosciences, Hydrogeology Research Group, 10587 Berlin, Germany. Electronic address: johannes.zirlewagen@tu-berlin.de.
[Ti] Título:Use of two artificial sweeteners, cyclamate and acesulfame, to identify and quantify wastewater contributions in a karst spring.
[So] Source:Sci Total Environ;547:356-365, 2016 Mar 15.
[Is] ISSN:1879-1026
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The identification and differentiation of different sources of contamination are crucial aspects of risk assessment in water resource protection. This is especially challenging in karst environments due to their highly heterogeneous flow fields. We have investigated the use of two artificial sweeteners, cyclamate and acesulfame, as an indicator set for contamination by wastewater within the rural catchment of a karst spring. The catchment was investigated in detail to identify the sources of artificial sweeteners and quantify their impact. Spring water was analysed following two different but typical recharge events: (1) a rain-on-snow event in winter, when no wastewater overflow from the sewer system was observed, and (2) an intense rainfall event in summer triggering an overflow from a stormwater detention basin. Acesulfame, which is known to be persistent, was quantified in all spring water samples. Its concentrations decreased after the winter event with no associated wastewater spillage but increased during the summer event following a recent input of untreated wastewater. Cyclamate, which is known to be degradable, was only detected following the wastewater inflow incident. The cyclamate signal matched very well the breakthrough of faecal indicator bacteria, indicating a common origin. Knowing the input function, cyclamate was used quantitatively as a tracer in transport modelling and the impact of 'combined sewer overflow' on spring water quality was quantified. Signals from artificial sweeteners were compared to those from bulk parameters (discharge, electrical conductivity and turbidity) and also to those from the herbicides atrazine and isoproturon, which indicate 'old' and 'fresh' flow components, respectively, both originating from croplands. High concentration levels of the artificial sweeteners in untreated wastewater (cyclamate and acesulfame) and in treated wastewater (acesulfame only) make them powerful indicators, especially in rural settings where wastewater input is relatively low, and in karst systems where dilution is often high.
[Mh] Termos MeSH primário: Ciclamatos/análise
Monitoramento Ambiental/métodos
Água Subterrânea/química
Tiazinas/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Chuvas
Estações do Ano
Edulcorantes/análise
Águas Residuais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclamates); 0 (Sweetening Agents); 0 (Thiazines); 0 (Waste Water); 0 (Water Pollutants, Chemical); MA3UYZ6K1H (acetosulfame)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE


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[PMID]:26795114
[Au] Autor:Villalba ML; Palestro P; Ceruso M; Gonzalez Funes JL; Talevi A; Bruno Blanch L; Supuran CT; Gavernet L
[Ad] Endereço:Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, 47 and 115, La Plata B1900BJW, Argentina.
[Ti] Título:Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action.
[So] Source:Bioorg Med Chem;24(4):894-901, 2016 Feb 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A set of N,N'-disubstituted sulfamides and sodium cyclamate have been tested for their inhibitory action against six isoforms of carbonic anhydrase (CA, EC 4.2.1.1) found in the brain, that is, CA I, CA II, CA VII, CA IX, CA XII and CA XIV, some of which are involved in epileptogenesis. The biological data showed interesting results for CA VII inhibition, the isozyme thought to be a novel antiepileptic target. Strong CA VII inhibitors, with Ki values in the low nanomolar-subnanomolar range were identified. Some of these derivatives showed selectivity for inhibition of CA VII versus the ubiquitous isoform CA II, for which the Ki values were in the micromolar range. Molecular modeling approaches were employed to understand the binding interactions between these compounds and the two CA isoforms, since the mechanism of action of such disubstituted sulfamides was not yet investigated by means of X-ray crystallography.
[Mh] Termos MeSH primário: Anticonvulsivantes/síntese química
Inibidores da Anidrase Carbônica/síntese química
Anidrases Carbônicas/química
Sulfonamidas/síntese química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Anticonvulsivantes/química
Sítios de Ligação
Inibidores da Anidrase Carbônica/química
Ciclamatos/química
Seres Humanos
Isoenzimas/antagonistas & inibidores
Isoenzimas/química
Cinética
Simulação de Acoplamento Molecular
Dados de Sequência Molecular
Ligação Proteica
Estrutura Secundária de Proteína
Relação Estrutura-Atividade
Sulfonamidas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Carbonic Anhydrase Inhibitors); 0 (Cyclamates); 0 (Isoenzymes); 0 (Sulfonamides); EC 4.2.1.1 (Carbonic Anhydrases); EC 4.2.1.1 (carbonic anhydrase VI)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160123
[St] Status:MEDLINE


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[PMID]:26406785
[Au] Autor:Janvier S; Goscinny S; Le Donne C; Van Loco J
[Ad] Endereço:a Department of Food, Medicines and Consumer Safety, Service of Consumer Safety , Scientific Institute of Public Health , Brussels , Belgium.
[Ti] Título:Low-calorie sweeteners in food and food supplements on the Italian market.
[So] Source:Food Addit Contam Part B Surveill;8(4):298-308, 2015.
[Is] ISSN:1939-3229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study determines the occurrence and concentration levels of artificial low-calorie sweeteners (LCSs) in food and food supplements on the Italian market. The analysed sample set (290 samples) was representative of the Italian market and comprised of beverages, jams, ketchups, confectionery, dairy products, table-top sweeteners and food supplements. All samples were analysed via UPLC-MS/MS. The method was in-house validated for the analysis of seven LCSs (aspartame, acesulfame-K, saccharin, sucralose, cyclamate, neotame and neohesperidin dihydrochalcone) in food and for five LCSs (aspartame, acesulfame-K, saccharin, cyclamate and sucralose) in food supplements. Except for cyclamate in one beverage which exceeded the maximum level (ML) with 13%, all concentrations measured in food were around or below the ML. In food supplements, 40 of the 52 samples (77%) were found to be above the ML, with exceedances of up to 200% of the ML.
[Mh] Termos MeSH primário: Dieta
Suplementos Nutricionais/análise
Aditivos Alimentares/análise
Edulcorantes/análise
[Mh] Termos MeSH secundário: Aspartame/análise
Cromatografia Líquida
Ciclamatos/análise
Dipeptídeos/análise
Ingestão de Energia
Contaminação de Alimentos/análise
Hesperidina/análogos & derivados
Hesperidina/análise
Seres Humanos
Itália
Sacarina/análise
Espectrometria de Massas em Tandem
Tiazinas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclamates); 0 (Dipeptides); 0 (Food Additives); 0 (Sweetening Agents); 0 (Thiazines); E750O06Y6O (Hesperidin); FST467XS7D (Saccharin); MA3UYZ6K1H (acetosulfame); OA5C88H3L0 (neohesperidin); VJ597D52EX (neotame); Z0H242BBR1 (Aspartame)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151030
[Lr] Data última revisão:
151030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150926
[St] Status:MEDLINE
[do] DOI:10.1080/19393210.2015.1094829



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