Base de dados : MEDLINE
Pesquisa : D02.455.426.392.368.367.379 [Categoria DeCS]
Referências encontradas : 2722 [refinar]
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  1 / 2722 MEDLINE  
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[PMID]:29367489
[Au] Autor:Ogura T; Sato T; Abe M; Okano T
[Ad] Endereço:Research & Development Headquarters, LION Corporation.
[Ti] Título:Small Angle X-ray Scattering and Electron Spin Resonance Spectroscopy Study on Fragrance Infused Cationic Vesicles Modeling Scent-Releasing Fabric Softeners.
[So] Source:J Oleo Sci;67(2):177-186, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Industrially relevant systems for household and personal-care products often involve a large number of components. Such multiple component formulations are indispensable and effective for functionalization of the products, but may simultaneously provide more complex structural features compared to those in ideal systems comprising a smaller number of highly pure substances. Using cryogenic transmission electron microscopy (cryo-TEM), small angle X-ray scattering (SAXS), and electron spin resonance (ESR) spectroscopy, we have investigated effects of fragrance-incorporation into cationic vesicles on their bilayer structures and membrane-membrane interactions. Cationic vesicles were prepared from TEQ surfactant, whose major component was di(alkyl fatty ester) quaternary ammonium methosulfate, and fragrance components, l-menthol, linalool, and d-limonene, were infused into the vesicle membranes to model scent-releasing fabric softeners. The cryo-TEM images confirm formation of multilamellar vesicles (MLVs). Generalized indirect Fourier transformation (GIFT) analysis of the SAXS intensities based on the modified Caillé structure factor model reveals that incorporation of a more hydrophobic fragrance component leads to a more pronounced increase of the surface separation (water layer thickness). Furthermore, the fragrance-infused systems show longer-range order of the bilayer correlations and enhanced undulation fluctuation of the membranes than those in the TEQ alone system. The spin-label ESR results indicate different restricted molecular motions in the TEQ bilayers depending on the labeled position and their marked changes upon addition of the fragrance components, suggesting different mixing schemes and solubilization positions of the fragrance molecules in the TEQ bilayers. The present data have demonstrated how the infused fragrance molecules having different hydrophobicity and molecular architectures into the cationic vesicles affect the membrane structures and the intermembrane interactions, which may provide useful information for precisely controlling a fragrance-releasing property.
[Mh] Termos MeSH primário: Cicloexenos/química
Espectroscopia de Ressonância de Spin Eletrônica
Mentol/química
Monoterpenos/química
Odorantes
Espalhamento a Baixo Ângulo
Terpenos/química
Difração de Raios X
[Mh] Termos MeSH secundário: Cátions
Interações Hidrofóbicas e Hidrofílicas
Bicamadas Lipídicas
Membranas Artificiais
Microscopia Eletrônica de Transmissão
Compostos Orgânicos/química
Compostos de Amônio Quaternário/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations); 0 (Cyclohexenes); 0 (Lipid Bilayers); 0 (Membranes, Artificial); 0 (Monoterpenes); 0 (Organic Chemicals); 0 (Quaternary Ammonium Compounds); 0 (Terpenes); 0 (fabric softeners); 1490-04-6 (Menthol); 9MC3I34447 (limonene); D81QY6I88E (linalool)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17186


  2 / 2722 MEDLINE  
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[PMID]:29427589
[Au] Autor:Vieira AJ; Beserra FP; Souza MC; Totti BM; Rozza AL
[Ad] Endereço:São Paulo State University (UNESP), Institute of Biosciences, Department of Morphology, Botucatu, Brazil.
[Ti] Título:Limonene: Aroma of innovation in health and disease.
[So] Source:Chem Biol Interact;283:97-106, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Natural products obtained in dietary components may aid the prevention and treatment of a variety of diseases. Reports in the scientific literature have demonstrated that the consumption of terpenes is a successful alternative in the treatment of several diseases, triggering beneficial biological effects in clinical and preclinical studies. The monoterpene limonene is largely used in alimentary items, cleaning products, and it is one of the most frequent fragrances used in cosmetics formulation. The therapeutic effects of limonene have been extensively studied, proving anti-inflammatory, antioxidant, antinociceptive, anticancer, antidiabetic, antihyperalgesic, antiviral, and gastroprotective effects, among other beneficial effects in health. In this review, we collected, presented, and analyzed evidence from the scientific literature regarding the usage of limonene and its activities and underlying mechanisms involved in combating diseases. The highlighting of limonene applications could develop a useful targeting of innovative research in this field as well as the development of a limonene-based phytomedicine which could be used in a variety of conditions of health and disease.
[Mh] Termos MeSH primário: Cicloexenos/uso terapêutico
Síndrome Metabólica/prevenção & controle
Terpenos/uso terapêutico
[Mh] Termos MeSH secundário: Analgésicos/química
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/química
Antioxidantes/farmacologia
Cicloexenos/química
Cicloexenos/farmacologia
Seres Humanos
Síndrome Metabólica/tratamento farmacológico
Síndrome Metabólica/patologia
Osteoartrite/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Plantas/química
Plantas/metabolismo
Terpenos/química
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Cyclohexenes); 0 (Terpenes); 9MC3I34447 (limonene)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180211
[St] Status:MEDLINE


  3 / 2722 MEDLINE  
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[PMID]:29306026
[Au] Autor:So EC; Wu SN; Lo YC; Su K
[Ad] Endereço:Department of Anesthesia, An Nan Hospital, China Medical University, 70965, Tainan City, Taiwan; Department of Anesthesia, China Medical University, 40447 Taichung City, Taiwan. Electronic address: d11320@mail.tmanh.org.tw.
[Ti] Título:Differential regulation of tefluthrin and telmisartan on the gating charges of I activation and inactivation as well as on resurgent and persistent I in a pituitary cell line (GH ).
[So] Source:Toxicol Lett;285:104-112, 2018 Mar 15.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Voltage-gated Na currents (I ), known to contain many components (e.g., transient, resurgent and persistent I ) with unique gating properties, are involved in the generation and propagation of action potentials in excitable cells. In this study, how tefluthrin (Tef), a synthetic pyrethoid, and telmisartan (TEL), blocker of angiotensin II receptors can perturb those components of I was investigated. The presence of either Tef or TEL increased the values of the gating charges of I involved in the activation (z ) and inactivation (z ). Tef also increased the amplitude of resurgent I (I ) or persistent I (I ) in a pituitary cell line (GH ), while TEL produced minimal effects on them. Subsequent addition of either ranolazine (a blocker of late I ) or d-limonene (a monoterpene), could reverse the changes by TEL or Tef on z or z . In SCN5A-expressing HEK293T cells, addition of Tef or TEL also increased the peak amplitude and the inactivation time constant of I which was accompanied by the increased z value of I . Taken together, the results indicated that Tef- or TEL-mediated changes in the gating kinetics of I are linked to their actions on functional activity of neurons, neuroendocrine or endocrine cells.
[Mh] Termos MeSH primário: Benzimidazóis/farmacologia
Benzoatos/farmacologia
Ciclopropanos/farmacologia
Hidrocarbonetos Fluorados/farmacologia
Ativação do Canal Iônico/efeitos dos fármacos
Somatotrofos/efeitos dos fármacos
Canais de Sódio Disparados por Voltagem/metabolismo
[Mh] Termos MeSH secundário: Potenciais de Ação/efeitos dos fármacos
Animais
Linhagem Celular Tumoral
Cicloexenos/farmacologia
Células HEK293
Seres Humanos
Canal de Sódio Disparado por Voltagem NAV1.5/genética
Canal de Sódio Disparado por Voltagem NAV1.5/metabolismo
Ranolazina/farmacologia
Ratos
Somatotrofos/metabolismo
Terpenos/farmacologia
Transfecção
Canais de Sódio Disparados por Voltagem/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzimidazoles); 0 (Benzoates); 0 (Cyclohexenes); 0 (Cyclopropanes); 0 (Hydrocarbons, Fluorinated); 0 (NAV1.5 Voltage-Gated Sodium Channel); 0 (SCN5A protein, human); 0 (Terpenes); 0 (Voltage-Gated Sodium Channels); 2HE8P42H2J (2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate); 9MC3I34447 (limonene); A6IEZ5M406 (Ranolazine); U5SYW473RQ (telmisartan)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180107
[St] Status:MEDLINE


  4 / 2722 MEDLINE  
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[PMID]:29303269
[Au] Autor:Liu S; Li X; Chen L; Li L; Li B; Zhu J
[Ad] Endereço:Ministry of Education Engineering Research Center of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Sciences and Engineering, South China University of Technology , Guangzhou 510640, China.
[Ti] Título:Tunable d-Limonene Permeability in Starch-Based Nanocomposite Films Reinforced by Cellulose Nanocrystals.
[So] Source:J Agric Food Chem;66(4):979-987, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to control d-limonene permeability, cellulose nanocrystals (CNC) were used to regulate starch-based film multiscale structures. The effect of sphere-like cellulose nanocrystal (CS) and rod-like cellulose nanocrystal (CR) on starch molecular interaction, short-range molecular conformation, crystalline structure, and micro-ordered aggregated region structure were systematically discussed. CNC aspect ratio and content were proved to be independent variables to control d-limonene permeability via film-structure regulation. New hydrogen bonding formation and increased hydroxypropyl starch (HPS) relative crystallinity could be the reason for the lower d-limonene permeability compared with tortuous path model approximation. More hydrogen bonding formation, higher HPS relative crystallinity and larger size of micro-ordered aggregated region in CS0.5 and CR2 could explain the lower d-limonene permeability than CS2 and CR0.5, respectively. This study provided new insight for the control of the flavor release from starch-based films, which favored its application in biodegradable food packaging and flavor encapsulation.
[Mh] Termos MeSH primário: Celulose/química
Nanocompostos/química
Nanopartículas/química
Amido/química
[Mh] Termos MeSH secundário: Cicloexenos
Embalagem de Alimentos/instrumentação
Ligações de Hidrogênio
Conformação Molecular
Permeabilidade
Terpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Terpenes); 9004-34-6 (Cellulose); 9005-25-8 (Starch); 9MC3I34447 (limonene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05457


  5 / 2722 MEDLINE  
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[PMID]:29202404
[Au] Autor:Zhu W; Liu X; Wang Y; Tong Y; Hu Y
[Ad] Endereço:Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China; ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, Hangzhou 310058, China.
[Ti] Título:Discovery of a novel series of α-terpineol derivatives as promising anti-asthmatic agents: Their design, synthesis, and biological evaluation.
[So] Source:Eur J Med Chem;143:419-425, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of novel α-terpineol derivatives were designed and synthesized through structural derivatization of the tertiary hydroxyl moiety or reduction of the double bond. Of the resulting compounds, eight compounds enhanced relaxation of airway smooth muscle (ASM) compared to the α-terpineol precursor, and four compounds (4a, 4d, 4e, and 4i)were superior or comparable to aminophylline at a concentration of 0.75 mmol/L. Assays for 3'-5'-Cyclic adenosine monophpsphate (cAMP) activation revealed that some representative α-terpineol derivatives in this series were capable of upregulating the level of cAMP in ASM cells. Further in vivo investigation using the asthmatic rat model, illustrated that treatment with the compounds 4a and 4e resulted in significantly lowered lung resistance (RL) and enhanced dynamic lung compliance (Cldyn), two important parameters for lung fuction. Moreover, treatment with 4e downregulated the levels of both IL-4 and IL-17. Due to its several favorable physiological functions, including ASM relaxation activity, cAMP activation capability, and in vivo anti-asthmatic efficacy, 4e is a promising remedy for bronchial asthma, meriting extensive development.
[Mh] Termos MeSH primário: Antiasmáticos/uso terapêutico
Asma/tratamento farmacológico
Cicloexenos/uso terapêutico
Descoberta de Drogas
Monoterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Administração Oral
Hidróxido de Alumínio/administração & dosagem
Animais
Antiasmáticos/administração & dosagem
Antiasmáticos/química
Asma/induzido quimicamente
Cicloexenos/administração & dosagem
Cicloexenos/química
Relação Dose-Resposta a Droga
Cobaias
Injeções Intraperitoneais
Masculino
Estrutura Molecular
Monoterpenos/administração & dosagem
Monoterpenos/química
Ovalbumina/administração & dosagem
Ratos
Ratos Sprague-Dawley
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Cyclohexenes); 0 (Monoterpenes); 21334LVV8W (alpha-terpineol); 5QB0T2IUN0 (Aluminum Hydroxide); 9006-59-1 (Ovalbumin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


  6 / 2722 MEDLINE  
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[PMID]:28873626
[Au] Autor:Tamaru S; Igura N; Shimoda M
[Ad] Endereço:Laboratory of Food Process Engineering, Division of Food Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
[Ti] Título:Effectiveness of water-air and octanol-air partition coefficients to predict lipophilic flavor release behavior from O/W emulsions.
[So] Source:Food Chem;239:712-717, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Flavor release from food matrices depends on the partition of volatile flavor compounds between the food matrix and the vapor phase. Thus, we herein investigated the relationship between released flavor concentrations and three different partition coefficients, namely octanol-water, octanol-air, and water-air, which represented the oil, water, and air phases present in emulsions. Limonene, 2-methylpyrazine, nonanal, benzaldehyde, ethyl benzoate, α-terpineol, benzyl alcohol, and octanoic acid were employed. The released concentrations of these flavor compounds from oil-in-water (O/W) emulsions were measured under equilibrium using static headspace gas chromatography. The results indicated that water-air and octanol-air partition coefficients correlated with the logarithms of the released concentrations in the headspace for highly lipophilic flavor compounds. Moreover, the same tendency was observed over various oil volume ratios in the emulsions. Our findings therefore suggest that octanol-air and water-air partition coefficients can be used to predict the released concentration of lipophilic flavor compounds from O/W emulsions.
[Mh] Termos MeSH primário: Octanóis/química
[Mh] Termos MeSH secundário: Cicloexenos
Emulsões
Monoterpenos
Óleos
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Emulsions); 0 (Monoterpenes); 0 (Octanols); 0 (Oils); 059QF0KO0R (Water); 21334LVV8W (alpha-terpineol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  7 / 2722 MEDLINE  
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[PMID]:28873614
[Au] Autor:He F; Qian YL; Qian MC
[Ad] Endereço:Department of Food Science and Technology, Oregon State University, Corvallis, OR 97331, United States.
[Ti] Título:Flavor and chiral stability of lemon-flavored hard tea during storage.
[So] Source:Food Chem;239:622-630, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Flavor stability of hard tea beverage was investigated over eight weeks of storage. The volatile compounds were analyzed using solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) and two-dimensional GC-MS. Quantitative analysis showed that the concentrations of linalool, citronellol, geranial, neral, geraniol, and nerol decreased dramatically during storage, whereas α-terpineol showed an increasing trend during storage. Heart-cut two-dimensional GC-MS (2D-GC-MS) chirality analysis showed that (R)-(+)-limonene, (R)-(-)-linalool, (S)-(-)-α-terpineol and (S)-(-)-4-terpineol dominated in the fresh hard tea samples, however, the configuration changed during storage for the terpene alcohols. The storage conditions did not change the configuration of limonene. A conversion of (R)-(-)-linalool to (S)-(+) form was observed during storage. Both (S)-α-terpineol and (S)-4-terpineol dominated at beginning of the storage, but (R)-(+)-α-terpineol became dominated after storage, suggested in addition to isomerization from (S)-α-terpineol, other precursors could also generate α-terpineol with (R)-isomer preference.
[Mh] Termos MeSH primário: Chá
[Mh] Termos MeSH secundário: Cicloexenos
Aromatizantes
Cromatografia Gasosa-Espectrometria de Massas
Isomerismo
Monoterpenos
Terpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Flavoring Agents); 0 (Monoterpenes); 0 (Tea); 0 (Terpenes); 21334LVV8W (alpha-terpineol); 9MC3I34447 (limonene)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  8 / 2722 MEDLINE  
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[PMID]:28873588
[Au] Autor:Li LJ; Hong P; Jiang ZD; Yang YF; Du XP; Sun H; Wu LM; Ni H; Chen F
[Ad] Endereço:College of Food and Biology Engineering, Jimei University, Xiamen, Fujian Province 361021, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen, Fujian Province 361021, China; Research Center of Food Biotechnology of Xiamen City, Xiamen, Fujian Province 361021,
[Ti] Título:Water accelerated transformation of d-limonene induced by ultraviolet irradiation and air exposure.
[So] Source:Food Chem;239:434-441, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:d-Limonene is a fragrant chemical that widely exists in aromatic products. Isotopic labelling of water molecules plus GC-MS and GC-PCI-Q-TOF analyses were used to investigate the influence of water molecules on chemical transformation of d-limonene induced by UV irradiation and air exposure. The results showed that the synergistic effect of UV irradiation, air exposure and water presence could facilitate d-limonene transformation into the limonene oxides: p-mentha-2,8-dienols, hydroperoxides, carveols, l-carvone and carvone oxide. UV irradiation, air exposure, or water alone, however, caused negligible d-limonene transformation. With the aid of isotopic labelling of water and oxygen molecules, it was found that water molecules were split into hydrogen radicals and hydroxyl radicals, and the hydrogen radicals, in particular, promoted the transformation reactions. This study has elucidated the mechanism and factors that influence the transformation of d-limonene, which will benefit industries involved in production and storage of d-limonene-containing products.
[Mh] Termos MeSH primário: Cicloexenos/química
Terpenos/química
[Mh] Termos MeSH secundário: Raios Ultravioleta
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclohexenes); 0 (Terpenes); 059QF0KO0R (Water); 9MC3I34447 (limonene)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  9 / 2722 MEDLINE  
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[PMID]:28960474
[Au] Autor:Cermak P; Olsovska J; Mikyska A; Dusek M; Kadleckova Z; Vanicek J; Nyc O; Sigler K; Bostikova V; Bostik P
[Ad] Endereço:Thomayer Hospital, Videnska 800, Prague, Czech Republic.
[Ti] Título:Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria.
[So] Source:APMIS;125(11):1033-1038, 2017 Nov.
[Is] ISSN:1600-0463
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C. difficile infection is problematic, making it imperative to search for new compounds with antimicrobial properties. Hops (Humulus lupulus L.) contain substances with antibacterial properties. We tested antimicrobial activity of purified hop constituents humulone, lupulone and xanthohumol against anaerobic bacteria. The antimicrobial activity was established against B. fragilis, C. perfringens and C. difficile strains according to standard testing protocols (CLSI, EUCAST), and the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were calculated. All C. difficile strains were toxigenic and clinically relevant, as they were isolated from patients with diarrhoea. Strongest antimicrobial effects were observed with xanthohumol showing MIC and MBC values of 15-107 µg/mL, which are close to those of conventional antibiotics in the strains of bacteria with increased resistance. Slightly higher MIC and MBC values were obtained with lupulone followed by higher values of humulone. Our study, thus, shows a potential of purified hop compounds, especially xanthohumol, as alternatives for treatment of infections caused by select anaerobic bacteria, namely nosocomial diarrhoea caused by resistant strains.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Clostridium difficile/efeitos dos fármacos
Cicloexenos/farmacologia
Flavonoides/farmacologia
Humulus/química
Propiofenonas/farmacologia
Terpenos/farmacologia
[Mh] Termos MeSH secundário: Anaerobiose/fisiologia
Antibacterianos/isolamento & purificação
Bacteroides fragilis/efeitos dos fármacos
Bacteroides fragilis/crescimento & desenvolvimento
Clostridium difficile/crescimento & desenvolvimento
Clostridium difficile/patogenicidade
Clostridium perfringens/efeitos dos fármacos
Clostridium perfringens/crescimento & desenvolvimento
Infecção Hospitalar/microbiologia
Cicloexenos/isolamento & purificação
Diarreia/microbiologia
Enterocolite Pseudomembranosa/microbiologia
Flavonoides/isolamento & purificação
Seres Humanos
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
Propiofenonas/isolamento & purificação
Simbiose/fisiologia
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cyclohexenes); 0 (Flavonoids); 0 (Plant Extracts); 0 (Propiophenones); 0 (Terpenes); B7425USG94 (lupulon); KHB4767H3K (humulon); T4467YT1NT (xanthohumol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE
[do] DOI:10.1111/apm.12747


  10 / 2722 MEDLINE  
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[PMID]:28867708
[Au] Autor:Inagaki F; Matsumoto M; Hira S; Mukai C
[Ad] Endereço:Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University.
[Ti] Título:Substrate Specific Silver(I)-Catalyzed Cycloisomerization of Diene Involving Alkyl Rearrangements: Syntheses of 1,2,5,6-Tetrahydrocuminic Acid, p-Menth-3-en-7-ol, and p-Menth-3-en-7-al.
[So] Source:Chem Pharm Bull (Tokyo);65(9):822-825, 2017.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The novel cationic Ag(I)-catalyzed cycloisomerization, which is associated with alkyl rearrangements, from dimethyl 2-allyl-2-prenylmalonate (1) to dimethyl 4-isopropylcyclohex-3-ene-1,1-dicarboxylate (2) has been developed. Derivatization from the diester 2 into the diol 3 and its X-ray crystallographic analysis determined the structure. The mechanisms of the novel reaction were investigated by isotopic experiments, which supported the unusual alkyl shifts. In addition, the product 2 was used for the total syntheses of three natural products, 1,2,5,6-tetrahydrocuminic acid (12), p-menth-3-en-7-ol (13), and p-menth-3-en-7-al (14) in short steps.
[Mh] Termos MeSH primário: Aldeídos/síntese química
Produtos Biológicos/síntese química
Cicloexenos/síntese química
Prata/química
[Mh] Termos MeSH secundário: Aldeídos/química
Produtos Biológicos/química
Catálise
Cristalografia por Raios X
Ciclização
Cicloexenos/química
Isomerismo
Conformação Molecular
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,2,5,6-tetrahydrocuminic acid); 0 (Aldehydes); 0 (Biological Products); 0 (Cyclohexenes); 0 (P-menth-3-en-7-ol); 0 (p-menth-3-en-7-al); 3M4G523W1G (Silver)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1248/cpb.c17-00433



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