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[PMID]:28290200
[Au] Autor:Sander J; Terhardt M; Sander S; Janzen N
[Ad] Endereço:Screening-Labor Hannover, P.O. Box 91 10 09, 30430 Hannover, Germany.
[Ti] Título:Quantification of Methylenecyclopropyl Compounds and Acyl Conjugates by UPLC-MS/MS in the Study of the Biochemical Effects of the Ingestion of Canned Ackee (Blighia sapida) and Lychee (Litchi chinensis).
[So] Source:J Agric Food Chem;65(12):2603-2608, 2017 Mar 29.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Consumption of ackee (Blighia sapida) and lychee (Litchi chinensis) fruit has led to severe poisoning. Considering their expanded agricultural production, toxicological evaluation has become important. Therefore, the biochemical effects of eating 1 g/kg canned ackee, containing 99.2 µmol/kg hypoglycin A, and 5 g/kg canned lychee, containing 1.3 µmol/kg hypoglycin A, were quantified in a self-experiment. Using ultra-high-performance liquid chromatography/mass spectrometry, hypoglycin A, methylenecyclopropylacetyl-glycine, and methylenecyclopropylformyl-glycine, as well as the respective carnitine conjugates, were found in urine after ingesting ackee. Hypoglycin A and its glycine derivative were also present in urine after eating lychee. Excretion of physiological acyl conjugates was significantly increased in the ackee experiment. Ingestion of ackee led to up to 15.1 nmol/L methylenecyclopropylacetyl-glycine and traces of methylenecyclopropylformyl-carnitine in the serum. These compounds were not found in the serum after eating lychee. Hypoglycin A accumulated in the serum in both experiments.
[Mh] Termos MeSH primário: Blighia/química
Contaminação de Alimentos/análise
Alimentos em Conserva/análise
Frutas/química
Hipoglicinas/análise
Litchi/química
[Mh] Termos MeSH secundário: Blighia/metabolismo
Blighia/toxicidade
Cromatografia Líquida de Alta Pressão
Ingestão de Alimentos
Embalagem de Alimentos
Alimentos em Conserva/toxicidade
Frutas/metabolismo
Frutas/toxicidade
Seres Humanos
Hipoglicinas/metabolismo
Hipoglicinas/toxicidade
Litchi/metabolismo
Litchi/toxicidade
Masculino
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycins); 156-56-9 (hypoglycin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b00224


  2 / 99 MEDLINE  
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[PMID]:27433981
[Au] Autor:Sander J; Terhardt M; Sander S; Janzen N
[Ad] Endereço:Screening-Labor Hannover, Postbox 91 10 09, 30430 Hannover, Germany. Electronic address: j.sander@metabscreen.de.
[Ti] Título:Quantification of hypoglycin A as butyl ester.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1029-1030:169-173, 2016 Sep 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:L-α-amino-methylenecyclopropyl propionic acid (Hypoglycin A, HGA) has been found to be the toxic compound in fruits of the Sapindaceae family causing acute intoxication when ingested as food or feed. Clinical symptoms are consistent with acquired multiple acyl-CoA dehydrogenase deficiency (MADD). Ultra performance liquid chromatography-tandem mass spectrometry was used to measure HGA after butylation. Sample volumes were 10µL for serum and 20µL for urine. Internal standard for HGA was d3-leucine, samples were plotted on a 7-point linear calibration curve. Coefficients of variation were <15% at 0.01µmol HGA/L and ≤4.1% at 10µmol/L. R(2) values for linearity were ≥0.995. In order to quantify non-metabolized HGA together with some of its metabolites plus a spectrum of acyl glycines and acyl carnitines typical for acquired MADD in one single analysis HGA measurement was integrated into a method which we previously developed for metabolites of HGA and acyl conjugates. The new method is suitable for biochemical diagnosis of Ackee fruit poisoning or atypical myopathy in horses and for forensic purposes in cases of suspected HGA poisoning.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Hipoglicinas/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Ração Animal/efeitos adversos
Ração Animal/análise
Animais
Esterificação
Doenças dos Cavalos/diagnóstico
Doenças dos Cavalos/etiologia
Cavalos
Hipoglicinas/toxicidade
Deficiência Múltipla de Acil Coenzima A Desidrogenase/diagnóstico
Deficiência Múltipla de Acil Coenzima A Desidrogenase/etiologia
Deficiência Múltipla de Acil Coenzima A Desidrogenase/veterinária
Doenças Musculares/diagnóstico
Doenças Musculares/etiologia
Doenças Musculares/veterinária
Intoxicação por Plantas/etiologia
Intoxicação por Plantas/veterinária
Sapindaceae/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycins); 156-56-9 (hypoglycin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE


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[PMID]:27374763
[Au] Autor:Lemieux H; Boemer F; van Galen G; Serteyn D; Amory H; Baise E; Cassart D; van Loon G; Marcillaud-Pitel C; Votion DM
[Ad] Endereço:Faculty Saint-Jean, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Mitochondrial function is altered in horse atypical myopathy.
[So] Source:Mitochondrion;30:35-41, 2016 09.
[Is] ISSN:1872-8278
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus (sycamore maple). Acylcarnitine concentrations in serum and muscle OXPHOS capacity were determined in 15 atypical myopathy cases. All but one acylcarnitine were out of reference range and mitochondrial respiratory capacity was severely decreased up to 49% as compared to 10 healthy controls. The hallmark of atypical myopathy thus consists of a severe alteration in the energy metabolism including a severe impairment in muscle mitochondrial respiration that could contribute to its high death rate.
[Mh] Termos MeSH primário: Doenças dos Cavalos/induzido quimicamente
Doenças dos Cavalos/patologia
Doenças Mitocondriais/veterinária
Doenças Musculares/veterinária
[Mh] Termos MeSH secundário: Acer/química
Ração Animal
Animais
Carnitina/análogos & derivados
Carnitina/sangue
Europa (Continente)
Feminino
Cavalos
Hipoglicinas/toxicidade
Masculino
Doenças Mitocondriais/induzido quimicamente
Doenças Mitocondriais/patologia
Músculos/patologia
Doenças Musculares/induzido quimicamente
Doenças Musculares/patologia
Fosforilação Oxidativa
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoglycins); 0 (acylcarnitine); 156-56-9 (hypoglycin); S7UI8SM58A (Carnitine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171121
[Lr] Data última revisão:
171121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160705
[St] Status:MEDLINE


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[PMID]:27367968
[Au] Autor:Isenberg SL; Carter MD; Hayes SR; Graham LA; Johnson D; Mathews TP; Harden LA; Takeoka GR; Thomas JD; Pirkle JL; Johnson RC
[Ad] Endereço:Battelle Memorial Institute at the Centers for Disease Control and Prevention , Atlanta, Georgia 30341, United States.
[Ti] Título:Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin A and Methylenecyclopropylglycine.
[So] Source:J Agric Food Chem;64(27):5607-13, 2016 Jul 13.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Methylenecyclopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in some soapberry fruits. Fatalities have been reported worldwide as a result of HGA ingestion, and exposure to MCPG has been implicated recently in the Asian outbreaks of hypoglycemic encephalopathy. In response to an outbreak linked to soapberry ingestion, the authors developed the first method to simultaneously quantify MCPG and HGA in soapberry fruits from 1 to 10 000 ppm of both toxins in dried fruit aril. Further, this is the first report of HGA in litchi, longan, and mamoncillo arils. This method is presented to specifically address the laboratory needs of public-health investigators in the hypoglycemic encephalitis outbreaks linked to soapberry fruit ingestion.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Ciclopropanos/análise
Frutas/química
Glicina/análogos & derivados
Hipoglicinas/análise
Sapindaceae/química
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Ciclopropanos/toxicidade
Frutas/toxicidade
Glicina/análise
Glicina/toxicidade
Hipoglicinas/toxicidade
Sapindaceae/toxicidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopropanes); 0 (Hypoglycins); 156-56-9 (hypoglycin); 2517-07-9 (methylenecyclopropylglycine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b02478


  5 / 99 MEDLINE  
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[PMID]:27254049
[Au] Autor:Vashishtha VM
[Ad] Endereço:Consultant Pediatrician, Mangla Hospital and Research Center, Bijnor, Uttar Pradesh, India. vipinipsita@gmail.com.
[Ti] Título:Outbreaks of Hypoglycemic Encephalopathy in Muzaffarpur, India: Are These Caused by Toxins in Litchi Fruit?: The Counterpoint.
[So] Source:Indian Pediatr;53(5):399-402, 2016 May 08.
[Is] ISSN:0974-7559
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Encefalopatias
Surtos de Doenças
Frutas
Hipoglicemia
Litchi/química
Toxinas Biológicas
[Mh] Termos MeSH secundário: Alanina/análogos & derivados
Encefalopatias/etiologia
Criança
Ciclopropanos
Frutas/efeitos adversos
Frutas/química
Seres Humanos
Hipoglicemia/epidemiologia
Hipoglicemia/etiologia
Hipoglicinas
Índia/epidemiologia
Toxinas Biológicas/efeitos adversos
Toxinas Biológicas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclopropanes); 0 (Hypoglycins); 0 (Toxins, Biological); 156-56-9 (hypoglycin); OF5P57N2ZX (Alanine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE


  6 / 99 MEDLINE  
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[PMID]:26965229
[Au] Autor:Sander J; Cavalleri JM; Terhardt M; Bochnia M; Zeyner A; Zuraw A; Sander S; Peter M; Janzen N
[Ad] Endereço:Screening-Labor Hannover, Germany (J Sander, Terhardt, S Sander, Peter, Janzen)Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany (Cavalleri)Department of Clinical Chemistry, Hannover Medical School, Hannover, Germany (Janzen)Department of Animal Nutrition,
[Ti] Título:Rapid diagnosis of hypoglycin A intoxication in atypical myopathy of horses.
[So] Source:J Vet Diagn Invest;28(2):98-104, 2016 Mar.
[Is] ISSN:1943-4936
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hypoglycin A (2-amino-3-(2-methylidenecyclopropyl)propanoic acid) is the plant toxin shown to cause atypical myopathy in horses. It is converted in vivo to methylenecyclopropyl acetic acid, which is transformed to a coenzyme A ester that subsequently blocks beta oxidation of fatty acids. Methylenecyclopropyl acetic acid is also conjugated with carnitine and glycine. Acute atypical myopathy may be diagnosed by quantifying the conjugates of methylenecyclopropyl acetic acid plus a selection of acyl conjugates in urine and serum. We describe a new mass spectrometric method for sample volumes of <0.5 mL. Samples were extracted with methanol containing 5 different internal standards. Extracts were analyzed by ultra-high-performance liquid chromatography-tandem mass spectrometry focusing on 11 metabolites. The total preparation time for a series of 20 samples was 100 min. Instrument run time was 14 min per sample. For the quantification of carnitine and glycine conjugates of methylenecyclopropyl acetic acid in urine, the coefficients of variation for intraday quantification were 2.9% and 3.0%, respectively. The respective values for interday were 9.3% and 8.0%. Methylenecyclopropyl acetyl carnitine was detected as high as 1.18 µmol/L in serum (median: 0.46 µmol/L) and 1.98 mmol/mol creatinine in urine (median: 0.79 mmol/mol creatinine) of diseased horses, while the glycine derivative accumulated up to 1.97 mmol/mol creatinine in urine but was undetectable in most serum samples. In serum samples from horses with atypical myopathy, the intraday coefficients of variation for C4-C8 carnitines and glycines were ≤4.5%. Measured concentrations exceeded those in healthy horses by ~10 to 1,400 times.
[Mh] Termos MeSH primário: Doenças dos Cavalos/diagnóstico
Hipoglicinas/toxicidade
Doenças Musculares/veterinária
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/veterinária
Doenças dos Cavalos/sangue
Doenças dos Cavalos/induzido quimicamente
Doenças dos Cavalos/urina
Cavalos
Doenças Musculares/induzido quimicamente
Doenças Musculares/diagnóstico
Intoxicação por Plantas/veterinária
Kit de Reagentes para Diagnóstico
Espectrometria de Massas em Tandem/veterinária
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycins); 0 (Reagent Kits, Diagnostic)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160312
[St] Status:MEDLINE
[do] DOI:10.1177/1040638715624736


  7 / 99 MEDLINE  
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[PMID]:26773562
[Au] Autor:Naylor R
[Ad] Endereço:Newmarket Equine Hospital, Suffolk, UK.
[Ti] Título:Atypical myopathy - insights on pathogenesis.
[So] Source:Equine Vet J;48(4):401-2, 2016 Jul.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Acer/química
Doenças dos Cavalos/etiologia
Hipoglicinas/toxicidade
Doenças Musculares/veterinária
[Mh] Termos MeSH secundário: Animais
Doenças dos Cavalos/patologia
Cavalos
Hipoglicinas/química
Músculo Esquelético/metabolismo
Doenças Musculares/etiologia
Doenças Musculares/patologia
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Hypoglycins); 156-56-9 (hypoglycin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160117
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12562


  8 / 99 MEDLINE  
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[PMID]:26593855
[Au] Autor:McKenzie RK; Hill FI; Habyarimana JA; Boemer F; Votion DM
[Ad] Endereço:a Matamata Veterinary Services , 26 Tainui St, Matamata 3400 , New Zealand.
[Ti] Título:Detection of hypoglycin A in the seeds of sycamore (Acer pseudoplatanus) and box elder (A. negundo) in New Zealand; the toxin associated with cases of equine atypical myopathy.
[So] Source:N Z Vet J;64(3):182-7, 2016 May.
[Is] ISSN:0048-0169
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CASE HISTORY AND CLINICAL FINDINGS: During April and May 2014 four horses aged between 5 months and 9 years, located in the Canterbury, Marlborough and Southland regions, presented with a variety of clinical signs including recumbency, stiffness, lethargy, dehydration, depression, and myoglobinuria suggestive of acute muscle damage. Two horses were subjected to euthanasia and two recovered. In all cases seeds of sycamore maple (Acer pseudoplatanus) or box elder (A. negundo) were present in the area where the horse had been grazing. LABORATORY INVESTIGATION: The samaras (seeds) of some Acer spp. may contain hypoglycin A, that has been associated with cases of atypical myopathy in Europe and North America. To determine if hypoglycin A is present in the samaras of Acer spp. in New Zealand, samples were collected from trees throughout the country that were associated with historical and/or current cases of atypical myopathy, and analysed for hypoglycin A. Serum samples from the four cases and four unaffected horses were analysed for the presence of hypoglycin A, profiles of acylcarnitines (the definitive diagnosis for atypical myopathy) and activities of creatine kinase and aspartate aminotransferase.Markedly elevated serum activities of creatine kinase and aspartate aminotransferase, and increased concentrations of selected acylcarnitines were found in the case horses. Hypoglycin A was detected in the serum of those horses but not in the healthy controls. Hypoglycin A was detected in 10/15 samples of samaras from sycamore maple and box elder from throughout New Zealand. DIAGNOSIS: Cases of atypical myopathy were diagnosed on properties where samaras containing hypoglycin A were also found. CLINICAL RELEVANCE: Sycamore and box elder trees in New Zealand are a source of hypoglycin A associated with the development of atypical myopathy. If pastured horses present with clinical and biochemical signs of severe muscle damage then the environment should be checked for the presence of these trees. Horses should be prevented from grazing samaras from Acer spp. in the autumn.
[Mh] Termos MeSH primário: Acer/química
Doenças dos Cavalos/induzido quimicamente
Hipoglicinas/toxicidade
Doenças Musculares/veterinária
Sementes/química
[Mh] Termos MeSH secundário: Animais
Doenças dos Cavalos/epidemiologia
Cavalos
Hipoglicinas/química
Masculino
Doenças Musculares/induzido quimicamente
Nova Zelândia/epidemiologia
Plantas Tóxicas/química
Plantas Tóxicas/toxicidade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hypoglycins); 156-56-9 (hypoglycin)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160331
[Lr] Data última revisão:
160331
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE
[do] DOI:10.1080/00480169.2015.1123123


  9 / 99 MEDLINE  
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[PMID]:26278545
[Au] Autor:Baise E; Habyarimana JA; Amory H; Boemer F; Douny C; Gustin P; Marcillaud-Pitel C; Patarin F; Weber M; Votion DM
[Ad] Endereço:Department of Animal Productions: Biostatistics, Economy and Animal Selection, Fundamental and Applied Research for Animals and Health (FARAH), Faculty of Veterinary Medicine, University of Liege, Belgium.
[Ti] Título:Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signs.
[So] Source:Equine Vet J;48(4):414-7, 2016 Jul.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:REASONS FOR PERFORMING STUDY: Ingestion of sycamore seeds (Acer pseudoplatanus) is the likely source of hypoglycin A in atypical myopathy (AM) but ingestion of seedlings in spring might also contribute to intoxication. OBJECTIVES: To test for hypoglycin A in seeds and seedlings collected on pastures where AM cases were reported and compare its concentration in serum of affected and healthy horses. STUDY DESIGN: Field investigation of clinical cases. METHODS: Whenever present, samaras (the winged nuts that each contain one seed) and/or seedlings were collected from pastures of 8 AM cases and 5 unaffected horses from different premises. Two AM cases were each co-grazing with an apparently healthy horse. Acylcarnitines and hypoglycin A were quantified in blood samples of all horses involved in the study. RESULTS: Hypoglycin A was detected in serum of AM (5.47 ± 1.60 µmol/l) but not in healthy controls pasturing where A. pseudoplatanus trees were not present. However, hypoglycin A was detected at high concentrations (7.98 µmol/l) in serum of a clinically healthy horse grazing a pasture with seedlings and samaras and also in the 2 healthy horses co-grazing with AM cases (0.43 ± 0.59 µmol/l). Hypoglycin A was detected in all samples of seeds and spring seedlings of A. pseudoplatanus. CONCLUSIONS: Atypical myopathy can be associated with the ingestion of sycamore samaras and also ingestion of seedlings. Hypoglycin A can be detected in the blood of horses with no detectable clinical signs at pasture in which there is A. pseudoplatanus. Determination of hypoglycin A concentration in blood is useful for screening for exposure in suspected cases of AM.
[Mh] Termos MeSH primário: Acer/química
Doenças dos Cavalos/induzido quimicamente
Hipoglicinas/toxicidade
Doenças Musculares/veterinária
Plântulas/química
[Mh] Termos MeSH secundário: Animais
Cavalos
Hipoglicinas/química
Doenças Musculares/induzido quimicamente
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycins); 156-56-9 (hypoglycin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150818
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12499


  10 / 99 MEDLINE  
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[PMID]:25970235
[Au] Autor:Zuraw A; Dietert K; Kühnel S; Sander J; Klopfleisch R
[Ad] Endereço:Department of Veterinary Pathology, Freie Universität Berlin, Germany.
[Ti] Título:Equine atypical myopathy caused by hypoglycin A intoxication associated with ingestion of sycamore maple tree seeds.
[So] Source:Equine Vet J;48(4):418-21, 2016 Jul.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:REASONS FOR PERFORMING STUDY: Evidence suggest there is a link between equine atypical myopathy (EAM) and ingestion of sycamore maple tree seeds. OBJECTIVES: To further evaluate the hypothesis that the ingestion of hypoglycin A (HGA) containing sycamore maple tree seeds causes acquired multiple acyl-CoA dehydrogenase deficiency and might be associated with the clinical and pathological signs of EAM. STUDY DESIGN: Case report. METHODS: Necropsy and histopathology, using hematoxylin and eosin and Sudan III stains, were performed on a 2.5-year-old mare that died following the development of clinical signs of progressive muscle stiffness and recumbency. Prior to death, the animal ingested sycamore maple tree seeds (Acer pseudoplatanus). Detection of metabolites in blood and urine obtained post mortem was performed by rapid ultra-performance liquid chromatography-tandem mass spectrometry. Data from this case were compared with 3 geldings with no clinical history of myopathy. RESULTS: Macroscopic examination revealed fragments of maple tree seeds in the stomach and severe myopathy of several muscle groups including Mm. intercostales, deltoidei and trapezii. Histologically, the affected muscles showed severe, acute rhabdomyolysis with extensive accumulation of finely dispersed fat droplets in the cytoplasm of degenerated skeletal muscle cells not present in controls. Urine and serum concentrations of several acyl carnitines and acyl glycines were increased, and both contained metabolites of HGA, a toxic amino acid present in sycamore maple tree seeds. CONCLUSIONS: The study supports the hypothesis that ingestion of HGA-containing maple tree seeds may cause EAM due to acquired multiple acyl-CoA dehydrogenase deficiency.
[Mh] Termos MeSH primário: Acer/química
Doenças dos Cavalos/induzido quimicamente
Hipoglicinas/toxicidade
Doenças Musculares/veterinária
Sementes/química
[Mh] Termos MeSH secundário: Animais
Evolução Fatal
Feminino
Cavalos
Hipoglicinas/química
Doenças Musculares/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hypoglycins); 156-56-9 (hypoglycin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150514
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12460



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