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Pesquisa : D02.455.426.559.389.097.280 [Categoria DeCS]
Referências encontradas : 140 [refinar]
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[PMID]:27905038
[Au] Autor:Neganova ME; Mishchenko DV; Serkova TP; Vystorop IV; Shevtsova EF
[Ad] Endereço:Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia. neganova83@mail.ru.
[Ti] Título:Biological Activity of Spirocyclic Hydroxamic Acids.
[So] Source:Bull Exp Biol Med;162(2):228-230, 2016 Dec.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Iron-chelating activity of synthesized spirocyclic hydroxamic acids, their toxicity, and effects on mitochondrial function were studied using primary culture of cerebral cortical neurons from newborn rats. All tested compounds effectively chelated Fe(II) ions. Activity of spirocyclic hydroxamic acids more strictly depended on the structure their piperidine, but not imidazolidine fragment. All compounds were non-toxic for normal neuronal culture.
[Mh] Termos MeSH primário: Ácidos Hidroxâmicos/farmacologia
Quelantes de Ferro/farmacologia
Ferro/metabolismo
Mitocôndrias Hepáticas/efeitos dos fármacos
Neurônios/efeitos dos fármacos
Compostos de Espiro/farmacologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Animais não Endogâmicos
Cátions Bivalentes
Sobrevivência Celular/efeitos dos fármacos
Córtex Cerebral/citologia
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Ferrozina/química
Ácidos Hidroxâmicos/síntese química
Quelantes de Ferro/síntese química
Masculino
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias Hepáticas/metabolismo
Dilatação Mitocondrial/efeitos dos fármacos
Neurônios/metabolismo
Cultura Primária de Células
Ratos
Compostos de Espiro/síntese química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cations, Divalent); 0 (Hydroxamic Acids); 0 (Iron Chelating Agents); 0 (Spiro Compounds); 28048-33-1 (Ferrozine); E1UOL152H7 (Iron)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161202
[St] Status:MEDLINE


  2 / 140 MEDLINE  
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[PMID]:26503658
[Au] Autor:Lindgren H; Sjöstedt A
[Ad] Endereço:Department of Clinical Microbiology, Clinical Bacteriology, and Laboratory for Molecular Infection Medicine Sweden, Umeå, Sweden.
[Ti] Título:Gallium Potentiates the Antibacterial Effect of Gentamicin against Francisella tularensis.
[So] Source:Antimicrob Agents Chemother;60(1):288-95, 2015 Oct 26.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The reasons why aminoglycosides are bactericidal have not been not fully elucidated, and evidence indicates that the cidal effects are at least partly dependent on iron. We demonstrate that availability of iron markedly affects the susceptibility of the facultative intracellular bacterium Francisella tularensis strain SCHU S4 to the aminoglycoside gentamicin. Specifically, the intracellular depots of iron were inversely correlated to gentamicin susceptibility, whereas the extracellular iron concentrations were directly correlated to the susceptibility. Further proof of the intimate link between iron availability and antibiotic susceptibility were the findings that a ΔfslA mutant, which is defective for siderophore-dependent uptake of ferric iron, showed enhanced gentamicin susceptibility and that a ΔfeoB mutant, which is defective for uptake of ferrous iron, displayed complete growth arrest in the presence of gentamicin. Based on the aforementioned findings, it was hypothesized that gallium could potentiate the effect of gentamicin, since gallium is sequestered by iron uptake systems. The ferrozine assay demonstrated that the presence of gallium inhibited >70% of the iron uptake. Addition of gentamicin and/or gallium to infected bone marrow-derived macrophages showed that both 100 µM gallium and 10 µg/ml of gentamicin inhibited intracellular growth of SCHU S4 and that the combined treatment acted synergistically. Moreover, treatment of F. tularensis-infected mice with gentamicin and gallium showed an additive effect. Collectively, the data demonstrate that SCHU S4 is dependent on iron to minimize the effects of gentamicin and that gallium, by inhibiting the iron uptake, potentiates the bactericidal effect of gentamicin in vitro and in vivo.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Francisella tularensis/efeitos dos fármacos
Gálio/farmacologia
Gentamicinas/farmacologia
Ferro/metabolismo
Tularemia/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Carga Bacteriana
Bioensaio
Sinergismo Farmacológico
Feminino
Ferrozina/química
Francisella tularensis/crescimento & desenvolvimento
Francisella tularensis/metabolismo
Transporte de Íons
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/microbiologia
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Macrófagos/microbiologia
Camundongos
Camundongos Endogâmicos C57BL
Cultura Primária de Células
Baço/efeitos dos fármacos
Baço/metabolismo
Baço/microbiologia
Tularemia/microbiologia
Tularemia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Gentamicins); 28048-33-1 (Ferrozine); CH46OC8YV4 (Gallium); E1UOL152H7 (Iron)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151028
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.01240-15


  3 / 140 MEDLINE  
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[PMID]:26274915
[Au] Autor:Chen L; Li X; Zhang J; Fang J; Huang Y; Wang P; Ma J
[Ad] Endereço:College of Biology and the Environment, Nanjing Forestry University , Nanjing 210037, China.
[Ti] Título:Production of Hydroxyl Radical via the Activation of Hydrogen Peroxide by Hydroxylamine.
[So] Source:Environ Sci Technol;49(17):10373-9, 2015 Sep 01.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The production of the hydroxyl radical (HO·) is important in environmental chemistry. This study reports a new source of HO· generated solely from hydrogen peroxide (H2O2) activated by hydroxylamine (HA). Electron paramagnetic resonance analysis and the oxidation of a HO· probe, benzoic acid, were used to confirm the production of HO·. The production of HO· increased with increasing concentrations of either HA or H2O2 as well as decreasing pH. The second-order rate constant for the reaction was (2.2 ± 0.2) × 10(-4) M(-1) s(-1). HO· was probably produced in two steps: the activation of H2O2 by protonated HA and then reaction between the H2O2 and the intermediate protonated aminoxyl radical generated in the first step. Such a two-step oxidation can possibly be ascribed to the ionizable hydroxyl moiety in the molecular structure of HA, as is suggested by comparing the reactivity of a series of HA derivatives in HO· production. The results shed light on a previously unknown source of HO· formation, which broadens the understanding of its role in environmental processes.
[Mh] Termos MeSH primário: Peróxido de Hidrogênio/química
Radical Hidroxila/química
Hidroxilamina/química
[Mh] Termos MeSH secundário: Óxidos N-Cíclicos/química
Espectroscopia de Ressonância de Spin Eletrônica
Ferrozina/química
Concentração de Íons de Hidrogênio
Indicadores e Reagentes
Quelantes de Ferro/química
Marcadores de Spin
Elementos de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclic N-Oxides); 0 (Indicators and Reagents); 0 (Iron Chelating Agents); 0 (Spin Labels); 0 (Transition Elements); 28048-33-1 (Ferrozine); 2FP81O2L9Z (Hydroxylamine); 3352-57-6 (Hydroxyl Radical); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150901
[Lr] Data última revisão:
150901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150815
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.5b00483


  4 / 140 MEDLINE  
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[PMID]:26146126
[Au] Autor:Galiniak S; Bartosz G; Sadowska-Bartosz I
[Ti] Título:Is Iron Chelation Important in Preventing Glycation of Bovine Serum Albumin in Vitro?
[So] Source:Cell Mol Biol Lett;20(4):562-70, 2015 Dec.
[Is] ISSN:1689-1392
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The role of metal (especially) iron ions has been postulated to play a prominent role in protein glycation, suggesting antiglycating effectiveness of metal chelators. However, this rule may not apply to all model glycation systems. We found that metal chelators are not effective in prevention of glycation of bovine serum albumin (BSA) in vitro, and there is no correlation between the antiglycating effects of 32 compounds and their iron chelation activity as measured with the ferrozine test. These data indicate that the glycation of BSA in vitro is iron-independent and is not a proper system to study the role of metals in protein glycation.
[Mh] Termos MeSH primário: Quelantes/química
Produtos Finais de Glicação Avançada
Soroalbumina Bovina/química
[Mh] Termos MeSH secundário: Catalase/química
Quelantes/farmacologia
Ferrozina/química
Ferrozina/metabolismo
Glioxal/química
Glioxal/metabolismo
Técnicas In Vitro
Concentração Inibidora 50
Ferro/química
Aldeído Pirúvico/química
Aldeído Pirúvico/metabolismo
Resinas Sintéticas/química
Soroalbumina Bovina/metabolismo
Superóxido Dismutase/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Glycation End Products, Advanced); 0 (Resins, Synthetic); 11139-85-8 (Chelex 100); 27432CM55Q (Serum Albumin, Bovine); 28048-33-1 (Ferrozine); 50NP6JJ975 (Glyoxal); 722KLD7415 (Pyruvaldehyde); E1UOL152H7 (Iron); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150707
[St] Status:MEDLINE


  5 / 140 MEDLINE  
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[PMID]:25645825
[Au] Autor:Dragset MS; Poce G; Alfonso S; Padilla-Benavides T; Ioerger TR; Kaneko T; Sacchettini JC; Biava M; Parish T; Argüello JM; Steigedal M; Rubin EJ
[Ad] Endereço:Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA Department of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway Centre of Molecular Inflammation Research and Department of Cancer Research and Molecular Medic
[Ti] Título:A novel antimycobacterial compound acts as an intracellular iron chelator.
[So] Source:Antimicrob Agents Chemother;59(4):2256-64, 2015 Apr.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations against a novel pyrazolopyrimidinone compound (PZP) that is active against M. tuberculosis have been identified within the gene cluster encoding the ESX-3 type VII secretion system. ESX-3 is required for mycobacterial iron acquisition through the mycobactin siderophore pathway, which could indicate that PZP restricts mycobacterial growth by targeting ESX-3 and thus iron uptake. Surprisingly, we show that ESX-3 is not the cellular target of the compound. We demonstrate that PZP indeed targets iron metabolism; however, we found that instead of inhibiting uptake of iron, PZP acts as an iron chelator, and we present evidence that the compound restricts mycobacterial growth by chelating intrabacterial iron. Thus, we have unraveled the unexpected mechanism of a novel antimycobacterial compound.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Quelantes de Ferro/farmacologia
Mycobacterium smegmatis/efeitos dos fármacos
Pirazóis/farmacologia
Pirimidinonas/farmacologia
[Mh] Termos MeSH secundário: Farmacorresistência Bacteriana/efeitos dos fármacos
Farmacorresistência Bacteriana/genética
Ferrozina/metabolismo
Ferro/metabolismo
Testes de Sensibilidade Microbiana
Mycobacterium smegmatis/genética
Oxazóis/metabolismo
Pirazóis/síntese química
Pirimidinonas/síntese química
RNA Bacteriano/metabolismo
Sideróforos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (3-(4-chlorophenyl)-5-(cyclohexylmethyl)pyrazolo(1,5-a)pyrimidin-7(4H)-one); 0 (Anti-Bacterial Agents); 0 (Iron Chelating Agents); 0 (Oxazoles); 0 (Pyrazoles); 0 (Pyrimidinones); 0 (RNA, Bacterial); 0 (Siderophores); 0 (mycobactins); 28048-33-1 (Ferrozine); E1UOL152H7 (Iron)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161202
[Lr] Data última revisão:
161202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150204
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.05114-14


  6 / 140 MEDLINE  
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[PMID]:24632099
[Au] Autor:Jeitner TM
[Ad] Endereço:Neurosciences, Winthrop University Hospital, Suite 502, 222 Station Plaza North, Mineola, NY 11501, USA. Electronic address: Tjeitner@Winthrop.org.
[Ti] Título:Optimized ferrozine-based assay for dissolved iron.
[So] Source:Anal Biochem;454:36-7, 2014 Jun 01.
[Is] ISSN:1096-0309
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The following report describes a simple and optimized assay for the detection of iron in solution based on the binding of this metal by ferrozine. This assay accurately measures between 1 and 200 µM sample iron concentrations within 2½ hours.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Ferrozina/química
Ferro/análise
Ferro/química
[Mh] Termos MeSH secundário: Absorção Fisico-Química
Limite de Detecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
28048-33-1 (Ferrozine); E1UOL152H7 (Iron)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:161025
[Lr] Data última revisão:
161025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140318
[St] Status:MEDLINE


  7 / 140 MEDLINE  
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[PMID]:24340076
[Au] Autor:Christides T; Sharp P
[Ad] Endereço:University of Greenwich, Faculty of Engineering & Science, Department of Life & Sports Science, Chatham Maritime, United Kingdom.
[Ti] Título:Sugars increase non-heme iron bioavailability in human epithelial intestinal and liver cells.
[So] Source:PLoS One;8(12):e83031, 2013.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies have suggested that sugars enhance iron bioavailability, possibly through either chelation or altering the oxidation state of the metal, however, results have been inconclusive. Sugar intake in the last 20 years has increased dramatically, and iron status disorders are significant public health problems worldwide; therefore understanding the nutritional implications of iron-sugar interactions is particularly relevant. In this study we measured the effects of sugars on non-heme iron bioavailability in human intestinal Caco-2 cells and HepG2 hepatoma cells using ferritin formation as a surrogate marker for iron uptake. The effect of sugars on iron oxidation state was examined by measuring ferrous iron formation in different sugar-iron solutions with a ferrozine-based assay. Fructose significantly increased iron-induced ferritin formation in both Caco-2 and HepG2 cells. In addition, high-fructose corn syrup (HFCS-55) increased Caco-2 cell iron-induced ferritin; these effects were negated by the addition of either tannic acid or phytic acid. Fructose combined with FeCl3 increased ferrozine-chelatable ferrous iron levels by approximately 300%. In conclusion, fructose increases iron bioavailability in human intestinal Caco-2 and HepG2 cells. Given the large amount of simple and rapidly digestible sugars in the modern diet their effects on iron bioavailability may have important patho-physiological consequences. Further studies are warranted to characterize these interactions.
[Mh] Termos MeSH primário: Epitélio/efeitos dos fármacos
Intestinos/efeitos dos fármacos
Ferro/farmacocinética
Fígado/efeitos dos fármacos
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Células CACO-2
Sacarose na Dieta/química
Ferritinas/química
Ferrozina/química
Frutose/química
Glucose/química
Células Hep G2
Seres Humanos
Adoçantes Calóricos/química
Ácido Fítico/química
Sacarose/química
Taninos/química
Zea mays
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Sucrose); 0 (Nutritive Sweeteners); 0 (Tannins); 28048-33-1 (Ferrozine); 30237-26-4 (Fructose); 57-50-1 (Sucrose); 7IGF0S7R8I (Phytic Acid); 9007-73-2 (Ferritins); E1UOL152H7 (Iron); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131217
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0083031


  8 / 140 MEDLINE  
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[PMID]:24140574
[Au] Autor:Im J; Lee J; Löffler FE
[Ad] Endereço:Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA; Center for Environmental Biotechnology, University of Tennessee, Knoxville, TN 37996, USA.
[Ti] Título:Interference of ferric ions with ferrous iron quantification using the ferrozine assay.
[So] Source:J Microbiol Methods;95(3):366-7, 2013 Dec.
[Is] ISSN:1872-8359
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The ferrozine assay is a widely used colorimetric method for determining soluble iron concentrations. We provide evidence for a heretofore unrecognized interference of ferric ions (Fe(3+)) on ferrous iron (Fe(2+)) measurements performed in the dark. Fe(3+) concentrations affected the absorbance measurements, which linearly increased with incubation time.
[Mh] Termos MeSH primário: Técnicas de Química Analítica
Colorimetria/métodos
Compostos Férricos/metabolismo
Compostos Ferrosos/análise
Ferrozina/metabolismo
Ferro/análise
[Mh] Termos MeSH secundário: Escuridão
Erros de Diagnóstico
Íons/análise
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Ferric Compounds); 0 (Ferrous Compounds); 0 (Ions); 28048-33-1 (Ferrozine); E1UOL152H7 (Iron)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:131206
[Lr] Data última revisão:
131206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131022
[St] Status:MEDLINE


  9 / 140 MEDLINE  
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[PMID]:24076399
[Au] Autor:Berlier G; Gastaldi L; Sapino S; Miletto I; Bottinelli E; Chirio D; Ugazio E
[Ad] Endereço:Università di Torino, Dipartimento di Chimica and NIS, Nanostructured Interfaces and Surfaces Centre of Excellence, Via Giuria 7, 10125 Torino, Italy.
[Ti] Título:MCM-41 as a useful vector for rutin topical formulations: synthesis, characterization and testing.
[So] Source:Int J Pharm;457(1):177-86, 2013 Nov 30.
[Is] ISSN:1873-3476
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Rutin, the glycoside of quercetin, could be used in topical preparations because of its antioxidant and radical scavenging properties, but its employ in cosmetic and pharmaceutical products is limited by poor physico-chemical stability. These issues were addressed by preparing, characterizing and testing rutin inclusion complexes with MCM-41 mesoporous silica. The effect of surface functionalization with aminopropyl groups (NH2-MCM-41) on the molecules properties was studied. The organic/inorganic interaction was confirmed by many techniques. In particular, the high inclusion of rutin in the pores of NH2-MCM-41 was assessed by XRD, TGA, gas-volumetric analysis (BET), while FTIR spectroscopy allowed to analyse with great detail the molecular interaction with the inorganic surface. Rutin was stabilized against UV degradation, mostly by its inclusion in NH2-MCM-41. Ex vivo studies showed a greater accumulation in porcine skin in the case of rutin complexed with NH2-MCM-41. Not only antioxidant properties of rutin were maintained after immobilization but, with aminopropyl silica, the metal-chelating activity increased noticeably. The immobilization of rutin in aminopropyl silica resulted in better performance in terms of activity and photostability, suggesting the importance of functionalization in stabilizing organic molecules within silica pores.
[Mh] Termos MeSH primário: Antioxidantes/química
Quelantes/química
Rutina/química
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Antioxidantes/administração & dosagem
Antioxidantes/efeitos da radiação
Quelantes/administração & dosagem
Quelantes/efeitos da radiação
Ferrozina/química
Técnicas In Vitro
Rutina/administração & dosagem
Rutina/efeitos da radiação
Dióxido de Silício/administração & dosagem
Dióxido de Silício/efeitos da radiação
Pele/metabolismo
Absorção Cutânea
Propriedades de Superfície
Suínos
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Chelating Agents); 0 (MCM-41); 28048-33-1 (Ferrozine); 5G06TVY3R7 (Rutin); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131001
[St] Status:MEDLINE


  10 / 140 MEDLINE  
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[PMID]:24001152
[Au] Autor:Kreitman GY; Cantu A; Waterhouse AL; Elias RJ
[Ad] Endereço:Department of Food Science, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
[Ti] Título:Effect of metal chelators on the oxidative stability of model wine.
[So] Source:J Agric Food Chem;61(39):9480-7, 2013 Oct 02.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxidation is a major problem with respect to wine quality, and winemakers have few tools at their disposal to control it. In this study, the effect of exogenous Fe(II) (bipyridine; Ferrozine) and Fe(III) chelators (ethylenediaminetetraacetic acid, EDTA; phytic acid) on nonenzymatic wine oxidation was examined. The ability of these chelators to affect the formation of 1-hydroxyethyl radicals (1-HER) and acetaldehyde was measured using a spin trapping technique with electron paramagnetic resonance (EPR) and by HPLC-PDA, respectively. The chelators were then investigated for their ability to prevent the oxidative loss of an important aroma-active thiol, 3-mercaptohexan-1-ol (3MH). The Fe(II)-specific chelators were more effective than the Fe(III) chelators with respect to 1-HER inhibition during the early stages of oxidation and significantly reduced oxidation markers compared to a control during the study. However, although the addition of Fe(III) chelators was less effective or even showed an initial pro-oxidant activity, the Fe(III) chelators proved to be more effective antioxidants compared to Fe(II) chelators after 8 days of accelerated oxidation. In addition, it is shown for the first time that Fe(II) and Fe(III) chelators can significantly inhibit the oxidative loss of 3MH in model wine.
[Mh] Termos MeSH primário: Conservantes de Alimentos/química
Qualidade dos Alimentos
Armazenamento de Alimentos
Quelantes de Ferro/química
Modelos Químicos
Vinho/análise
[Mh] Termos MeSH secundário: 2,2'-Dipiridil/química
Ácido Edético/química
Ferrozina/química
Oxirredução
Ácido Fítico/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Preservatives); 0 (Iron Chelating Agents); 28048-33-1 (Ferrozine); 551W113ZEP (2,2'-Dipyridyl); 7IGF0S7R8I (Phytic Acid); 9G34HU7RV0 (Edetic Acid)
[Em] Mês de entrada:1407
[Cu] Atualização por classe:131125
[Lr] Data última revisão:
131125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130905
[St] Status:MEDLINE
[do] DOI:10.1021/jf4024504



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