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Pesquisa : D02.455.426.559.389.150.750 [Categoria DeCS]
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[PMID]:29176834
[Au] Autor:Wieczorek A; Dulski K; Niedzwiecki S; Alfs D; Bialas P; Curceanu C; Czerwinski E; Danel A; Gajos A; Glowacz B; Gorgol M; Hiesmayr B; Jasinska B; Kacprzak K; Kaminska D; Kaplon L; Kochanowski A; Korcyl G; Kowalski P; Kozik T; Krzemien W; Kubicz E; Kucharek M; Mohammed M; Pawlik-Niedzwiecka M; Palka M; Raczynski L; Rudy Z; Rundel O; Sharma NG; Silarski M; Uchacz T; Wislicki W; Zgardzinska B; Zielinski M; Moskal P
[Ad] Endereço:Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.
[Ti] Título:Novel scintillating material 2-(4-styrylphenyl)benzoxazole for the fully digital and MRI compatible J-PET tomograph based on plastic scintillators.
[So] Source:PLoS One;12(11):e0186728, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A novel plastic scintillator is developed for the application in the digital positron emission tomography (PET). The novelty of the concept lies in application of the 2-(4-styrylphenyl)benzoxazole as a wavelength shifter. The substance has not been used as scintillator dopant before. A dopant shifts the scintillation spectrum towards longer wavelengths making it more suitable for applications in scintillators of long strips geometry and light detection with digital silicon photomultipliers. These features open perspectives for the construction of the cost-effective and MRI-compatible PET scanner with the large field of view. In this article we present the synthesis method and characterize performance of the elaborated scintillator by determining its light emission spectrum, light emission efficiency, rising and decay time of the scintillation pulses and resulting timing resolution when applied in the positron emission tomography. The optimal concentration of the novel wavelength shifter was established by maximizing the light output and it was found to be 0.05 ‰ for cuboidal scintillator with dimensions of 14 mm x 14 mm x 20 mm.
[Mh] Termos MeSH primário: Benzoxazóis/química
Imagem por Ressonância Magnética
Tomografia por Emissão de Pósitrons
Contagem de Cintilação/instrumentação
Estirenos/química
Tomografia
[Mh] Termos MeSH secundário: Luz
Peso Molecular
Polimerização
Espectrometria de Fluorescência
Temperatura Ambiente
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoxazoles); 0 (Styrenes)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186728


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[PMID]:28951217
[Au] Autor:Andersen ME; Cruzan G; Black MB; Pendse SN; Dodd D; Bus JS; Sarang SS; Banton MI; Waites R; McMullen PD
[Ad] Endereço:ScitoVation LLC, Six Davis Drive, PO Box 12878, Research Triangle Park, NC 27709, United States.
[Ti] Título:Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.
[So] Source:Toxicol Appl Pharmacol;335:28-40, 2017 Nov 15.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three strains of male mice (the parental C57BL/6 strain, a CYP2F2(-/-) knock out and a CYP2F2(-/-) transgenic containing human CYP2F1, 2A13 and 2B6). Exposures were for 1-day and 1, 4 and 26weeks. After 1-day exposures at 1, 5, 10, 20, 40 and 120ppm significant increases in differentially expressed genes (DEGs) occurred only in parental strain lungs where there was already an increase in DEGs at 5ppm and then many thousands of DEGs by 120ppm. Enrichment for 1-day and 1-week exposures included cell cycle, mitotic M-M/G1 phases, DNA-synthesis and metabolism of lipids and lipoproteins pathways. The numbers of DEGs decreased steadily over time with no DEGs meeting both statistical significance and fold-change criteria at 26weeks. At 4 and 26weeks, some key transcription factors (TFs) - Nr1d1, Nr1d2, Dbp, Tef, Hlf, Per3, Per2 and Bhlhe40 - were upregulated (|FC|>1.5), while others - Npas, Arntl, Nfil3, Nr4a1, Nr4a2, and Nr4a3 - were down-regulated. At all times, consistent changes in gene expression only occurred in the parental strain. Our results support a MIE for styrene of direct mitogenicity from mouse-specific CYP2F2-mediated metabolites activating Nr4a signaling. Longer-term MFs include down-regulation of Nr4a genes and shifts in both circadian clock TFs and other TFs, linking circadian clock to cellular metabolism. We found no gene expression changes indicative of cytotoxicity or activation of p53-mediated DNA-damage pathways.
[Mh] Termos MeSH primário: Perfilação da Expressão Gênica/métodos
Pulmão/efeitos dos fármacos
Estirenos/toxicidade
Toxicogenética/métodos
Transcriptoma/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Hidrocarboneto de Aril Hidroxilases/genética
Hidrocarboneto de Aril Hidroxilases/metabolismo
Ritmo Circadiano/efeitos dos fármacos
Ritmo Circadiano/genética
Peptídeos e Proteínas de Sinalização do Ritmo Circadiano/genética
Peptídeos e Proteínas de Sinalização do Ritmo Circadiano/metabolismo
Citocromo P-450 CYP2B6/genética
Citocromo P-450 CYP2B6/metabolismo
Sistema Enzimático do Citocromo P-450/deficiência
Sistema Enzimático do Citocromo P-450/genética
Família 2 do Citocromo P450/genética
Família 2 do Citocromo P450/metabolismo
Relação Dose-Resposta a Droga
Redes Reguladoras de Genes/efeitos dos fármacos
Genótipo
Exposição por Inalação/efeitos adversos
Peptídeos e Proteínas de Sinalização Intracelular/genética
Peptídeos e Proteínas de Sinalização Intracelular/metabolismo
Pulmão/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Modelos Animais
Fenótipo
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
Estirenos/metabolismo
Fatores de Tempo
Fatores de Transcrição/genética
Fatores de Transcrição/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Circadian Rhythm Signaling Peptides and Proteins); 0 (Intracellular Signaling Peptides and Proteins); 0 (Styrenes); 0 (Transcription Factors); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.14.14.- (Cyp2f2 protein, mouse); EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases); EC 1.14.14.1 (CYP2A13 protein, human); EC 1.14.14.1 (CYP2B6 protein, human); EC 1.14.14.1 (CYP2F1 protein, human); EC 1.14.14.1 (Cytochrome P-450 CYP2B6); EC 1.14.14.1 (Cytochrome P450 Family 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:28674327
[Au] Autor:Trabelsi I; Essid K; Frikha MH
[Ad] Endereço:Laboratory of Physical and Organic Chemistry: Department of Chemistry, Faculty of Sciences in Sfax.
[Ti] Título:Esterification of Mixed Carboxylic-fatty Anhydrides Using Amberlyst-15 as Heterogeneous Catalyst.
[So] Source:J Oleo Sci;66(7):667-676, 2017.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The article deals with the use of mixed anhydrides for the synthesis of fatty esters. Both aliphatic and aromatic acids are involved, indicating different behaviors according to the chain length of the aliphatic acid. We describe a novel and efficient method for the synthesis of fatty esters by the esterification reaction of primary, secondary and tertiary alcohols with mixed carboxylic-palmitic anhydrides using resin Amberlyst-15 as heterogeneous acid catalyst. Influence of various reaction parameters such as molar ratio (anhydride/alcohol), catalyst amount, type of alcohol and type of mixed anhydride were studied to optimize the conditions for maximum yield. Among tested anhydrides we quote mainly the 4-chlorobenzoic palmitic anhydride because it was both reactive and selective for the preparation of palmitic acid ester. This anhydride gave a good yield of palmitic ester.
[Mh] Termos MeSH primário: Anidridos/química
Ésteres/síntese química
Ácidos Graxos/química
Estirenos/química
[Mh] Termos MeSH secundário: Ácidos Carboxílicos/química
Catálise
Clorobenzoatos/química
Esterificação
Ácido Palmítico/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anhydrides); 0 (Carboxylic Acids); 0 (Chlorobenzoates); 0 (Esters); 0 (Fatty Acids); 0 (Styrenes); 0 (amberlyst-15); 2V16EO95H1 (Palmitic Acid); IC7888DF4L (4-chlorobenzoic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17008


  4 / 2530 MEDLINE  
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[PMID]:28662853
[Au] Autor:Chen S; Li XX; Shu L; Somsundaran P; Li JR
[Ad] Endereço:Key Laboratory of Beijing on Regional Air Pollution Control, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, PR China. Electronic address: chensha@bjut.edu.cn.
[Ti] Título:The high efficient separation of divinylbenzene and ethylvinylbenzene isomers using high performance liquid chromatography with Fe-based MILs packed columns.
[So] Source:J Chromatogr A;1510:25-32, 2017 Aug 11.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The baseline separation of divinylbenzene (DVB) and ethylvinylbenzene (EVB) isomers was achieved using HPLC with MIL-53(Fe) and MIL-100(Fe) packed columns respectively when hexane/dichloromethane (100:0) used as mobile phase, at flow rate of 0.5mLmin , room temperature, and monitored with a UV detector at 254nm. The two Fe-based MILs packed columns showed different separated performances, analytes had short retention time on MIL-100(Fe) compared to MIL-53(Fe), but selectivity of DVB isomers (m-DVB and p-DVB) was lower, which was mainly due to the differences of the pore size and structure of MILs. Moreover, the results of calculated thermodynamic parameters showed that the separation of DVB and EVB isomers was not only controlled by enthalpy change (ΔH), but also controlled by entropy change (ΔS). The head-to-tail stacking was the main reason for the separation according to the mechanism of the DVB and EVB isomers on Fe-based MILs packed columns.
[Mh] Termos MeSH primário: Técnicas de Química Analítica/métodos
Cromatografia Líquida de Alta Pressão
Compostos Organometálicos/isolamento & purificação
Estirenos/isolamento & purificação
Compostos de Vinila/isolamento & purificação
[Mh] Termos MeSH secundário: Técnicas de Química Analítica/instrumentação
Hexanos/química
Ferro/química
Isomerismo
Cloreto de Metileno/química
Compostos Organometálicos/química
Estirenos/química
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hexanes); 0 (Organometallic Compounds); 0 (Styrenes); 0 (Vinyl Compounds); 588X2YUY0A (Methylene Chloride); E1UOL152H7 (Iron); IZ715T4SBU (divinyl benzene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE


  5 / 2530 MEDLINE  
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[PMID]:28500555
[Au] Autor:Wang YY; Chen YK; Hu SC; Hsu YL; Tsai CH; Chi TC; Huang WL; Hsieh PW; Yuan SF
[Ad] Endereço:Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
[Ti] Título:CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis.
[So] Source:Cancer Chemother Pharmacol;79(6):1129-1140, 2017 Jun.
[Is] ISSN:1432-0843
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The ß-nitrostyrene family has been previously reported to possess anticancer property. However, the biological effects of ß-nitrostyrenes on ovarian cancer and the underlying mechanisms involved remain unclear. In the present study, we synthesized a ß-nitrostyrene derivative, CYT-Rx20 3'-hydroxy-4'-methoxy-ß-methyl-ß-nitrostyrene), and investigated its anticancer effects and the putative pathways of action in ovarian cancer. METHODS: The effects of CYT-Rx20 were analyzed using cell viability assay, reactive oxygen species (ROS) generation assay, FACS analysis, annexin V staining, immunostaining, comet assay, immunoblotting, soft agar assay, migration assay, nude mice xenograft study and immunohistochemistry. RESULTS: CYT-Rx20 induced cytotoxicity in ovarian cancer cells by promoting cell apoptosis via ROS generation and DNA damage. CYT-Rx20-induced cell apoptosis, ROS generation and DNA damage were reversed by thiol antioxidants. In addition, CYT-Rx20 inhibited ovarian cancer cell migration by regulating the expression of epithelial to mesenchymal transition (EMT) markers. In nude mice, CYT-Rx20 inhibited ovarian tumor growth accompanied by increased expression of DNA damage marker γH2AX and decreased expression of EMT marker Vimentin. CONCLUSIONS: CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo, and has the potential to be further developed into an anti-ovarian cancer drug clinically.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Dano ao DNA
Neoplasias Ovarianas/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Estirenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Ensaio Cometa
Feminino
Histonas/biossíntese
Histonas/genética
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Nus
Espécies Reativas de Oxigênio/metabolismo
Vimentina/biossíntese
Vimentina/genética
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3-hydroxy-4-methoxy-beta-methyl-beta-nitrostyrene); 0 (Antineoplastic Agents); 0 (H2AFX protein, human); 0 (Histones); 0 (Reactive Oxygen Species); 0 (Styrenes); 0 (Vimentin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170613
[Lr] Data última revisão:
170613
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE
[do] DOI:10.1007/s00280-017-3330-9


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[PMID]:28388815
[Au] Autor:Burmudzija AZ; Muskinja JM; Kosanic MM; Rankovic BR; Novakovic SB; Dordevic SB; Stanojkovic TP; Baskic DD; Ratkovic ZR
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, RS-34000, Kragujevac, Serbia.
[Ti] Título:Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives.
[So] Source:Chem Biodivers;14(8), 2017 Aug.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC = 8.63 µm), while benzyl one is active against LS174 and A549 cell lines (IC = 10.17 and 12.15 µm, respectively).
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Estirenos/química
[Mh] Termos MeSH secundário: Células A549
Anti-Infecciosos/farmacologia
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Cristalografia por Raios X
Ciclopropanos/química
Ensaios de Seleção de Medicamentos Antitumorais
Fungos/efeitos dos fármacos
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Células HeLa
Seres Humanos
Testes de Sensibilidade Microbiana
Conformação Molecular
Relação Estrutura-Atividade
Estirenos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Cyclopropanes); 0 (Styrenes); 7B8994OHJ0 (cyclopropene); 8CJX5I27B7 (methyl-3-methoxy-4-hydroxystyryl ketone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201700077


  7 / 2530 MEDLINE  
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[PMID]:28387742
[Au] Autor:Laur E; Kirillov E; Carpentier JF
[Ad] Endereço:Université de Rennes 1, CNRS, Institut des Sciences Chimiques de Rennes, UMR 6226, F-35042 Rennes CEDEX, France. eva.laur@univ-rennes1.fr.
[Ti] Título:Engineering of Syndiotactic and Isotactic Polystyrene-Based Copolymers via Stereoselective Catalytic Polymerization.
[So] Source:Molecules;22(4), 2017 Apr 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This contribution presents an updated overview of the different copolymers containing stereoregular polystyrene blocks. Special emphasis is placed on syndiospecific and isospecific copolymerization of styrene with co-monomers (ethylene and α-olefins, conjugated and non-conjugated dienes, styrene derivatives, etc.). The catalytic systems involved are described and the polymerization mechanisms are discussed. Alternative approaches (simultaneous, living, chain-transfer and graft copolymerization) and the resulting detailed structures and characteristics of the copolymers are also reported.
[Mh] Termos MeSH primário: Polimerização
Polímeros/química
Poliestirenos/química
[Mh] Termos MeSH secundário: Alcenos/química
Catálise
Etilenos/química
Metais/química
Estirenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Alkenes); 0 (Ethylenes); 0 (Metals); 0 (Polymers); 0 (Polystyrenes); 0 (Styrenes); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE


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[PMID]:28285258
[Au] Autor:Roberts BF; Zheng Y; Cleaveleand J; Lee S; Lee E; Ayong L; Yuan Y; Chakrabarti D
[Ad] Endereço:Division of Molecular Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
[Ti] Título:4-Nitro styrylquinoline is an antimalarial inhibiting multiple stages of Plasmodium falciparum asexual life cycle.
[So] Source:Int J Parasitol Drugs Drug Resist;7(1):120-129, 2017 Apr.
[Is] ISSN:2211-3207
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Drugs against malaria are losing their effectiveness because of emerging drug resistance. This underscores the need for novel therapeutic options for malaria with mechanism of actions distinct from current antimalarials. To identify novel pharmacophores against malaria we have screened compounds containing structural features of natural products that are pharmacologically relevant. This screening has identified a 4-nitro styrylquinoline (SQ) compound with submicromolar antiplasmodial activity and excellent selectivity. SQ exhibits a cellular action distinct from current antimalarials, acting early on malaria parasite's intraerythrocytic life cycle including merozoite invasion. The compound is a fast-acting parasitocidal agent and also exhibits curative property in the rodent malaria model when administered orally. In this report, we describe the synthesis, preliminary structure-function analysis, and the parasite developmental stage specific action of the SQ scaffold.
[Mh] Termos MeSH primário: Aminoquinolinas/farmacologia
Antimaláricos/farmacologia
Descoberta de Drogas
Plasmodium falciparum/efeitos dos fármacos
Estirenos/farmacologia
[Mh] Termos MeSH secundário: Administração Oral
Aminoquinolinas/química
Aminoquinolinas/uso terapêutico
Animais
Antimaláricos/química
Antimaláricos/uso terapêutico
Eritrócitos/parasitologia
Estágios do Ciclo de Vida/efeitos dos fármacos
Malária/tratamento farmacológico
Malária/parasitologia
Merozoítos/efeitos dos fármacos
Testes de Sensibilidade Parasitária
Plasmodium berghei
Plasmodium falciparum/crescimento & desenvolvimento
Ratos
Estirenos/química
Estirenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoquinolines); 0 (Antimalarials); 0 (Styrenes); 0 (UCF 501)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  9 / 2530 MEDLINE  
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[PMID]:28279165
[Au] Autor:Plett KL; Raposo AE; Bullivant S; Anderson IC; Piller SC; Plett JM
[Ad] Endereço:Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia.
[Ti] Título:Root morphogenic pathways in Eucalyptus grandis are modified by the activity of protein arginine methyltransferases.
[So] Source:BMC Plant Biol;17(1):62, 2017 Mar 09.
[Is] ISSN:1471-2229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Methylation of proteins at arginine residues, catalysed by members of the protein arginine methyltransferase (PRMT) family, is crucial for the regulation of gene transcription and for protein function in eukaryotic organisms. Inhibition of the activity of PRMTs in annual model plants has demonstrated wide-ranging involvement of PRMTs in key plant developmental processes, however, PRMTs have not been characterised or studied in long-lived tree species. RESULTS: Taking advantage of the recently available genome for Eucalyptus grandis, we demonstrate that most of the major plant PRMTs are conserved in E. grandis as compared to annual plants and that they are expressed in all major plant tissues. Proteomic and transcriptomic analysis in roots suggest that the PRMTs of E. grandis control a number of regulatory proteins and genes related to signalling during cellular/root growth and morphogenesis. We demonstrate here, using chemical inhibition of methylation and transgenic approaches, that plant type I PRMTs are necessary for normal root growth and branching in E. grandis. We further show that EgPRMT1 has a key role in root hair initiation and elongation and is involved in the methylation of ß-tubulin, a key protein in cytoskeleton formation. CONCLUSIONS: Together, our data demonstrate that PRMTs encoded by E. grandis methylate a number of key proteins and alter the transcription of a variety of genes involved in developmental processes. Appropriate levels of expression of type I PRMTs are necessary for the proper growth and development of E. grandis roots.
[Mh] Termos MeSH primário: Eucalyptus/enzimologia
Proteínas de Plantas/metabolismo
Raízes de Plantas/fisiologia
Proteína-Arginina N-Metiltransferases/metabolismo
[Mh] Termos MeSH secundário: Inibidores Enzimáticos/farmacologia
Eucalyptus/fisiologia
Perfilação da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Meristema/efeitos dos fármacos
Meristema/genética
Meristema/crescimento & desenvolvimento
Metilação
Proteínas de Plantas/genética
Raízes de Plantas/metabolismo
Plantas Geneticamente Modificadas
Proteína-Arginina N-Metiltransferases/antagonistas & inibidores
Proteína-Arginina N-Metiltransferases/genética
Estirenos/farmacologia
Tubulina (Proteína)/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Proteins); 0 (Styrenes); 0 (Tubulin); EC 2.1.1.319 (Protein-Arginine N-Methyltransferases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1186/s12870-017-1010-x


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[PMID]:28199759
[Au] Autor:Huang J; Zhang L; Tang Z; Wu S; Ning N; Sun H; Guo B
[Ad] Endereço:Department of Polymer Materials and Engineering, South China University of Technology, Guangzhou, 510640, P. R. China.
[Ti] Título:Bioinspired Design of a Robust Elastomer with Adaptive Recovery via Triazolinedione Click Chemistry.
[So] Source:Macromol Rapid Commun;38(7), 2017 Apr.
[Is] ISSN:1521-3927
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:It is a significant but challenging task to simultaneously reinforce and functionalize diene rubbers. Inspired by "sacrificial bonds", the authors engineer sacrificial hydrogen bonds formed by pendent urazole groups in crosslinked solution-polymerized styrene butadiene rubber (SSBR) via triazolinedione click chemistry. This post-crosslinking modification reveals the effects of the sacrificial bonds based on a consistent covalent network. The "cage effect" of the pre-crosslinked network facilitates the heterogeneous distribution of urazole groups, leading to the formation of hydrogen-bonded multiplets. These multiplets further aggregate into clusters with vicinal trapped polymer segments that form microphase separation from the SSBR matrix with a low content of urazole groups. The clusters based on hydrogen bonds, serving as sacrificial bonds, promote energy dissipation, significantly improving the mechanical properties of the modified SSBR, and enable an additional wide transition temperature region above room temperature, which endows the modified SSBR with promising triple-shape memory behavior.
[Mh] Termos MeSH primário: Butadienos/química
Butadienos/síntese química
Química Click
Elastômeros/química
Elastômeros/síntese química
Estirenos/química
Estirenos/síntese química
Triazóis/química
[Mh] Termos MeSH secundário: Biomimética
Ligações de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Butadienes); 0 (Elastomers); 0 (Styrenes); 0 (Triazoles); 61789-96-6 (styrene-butadiene rubber)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1002/marc.201600678



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