Base de dados : MEDLINE
Pesquisa : D02.455.426.559.389.150.750.800.830 [Categoria DeCS]
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[PMID]:29175402
[Au] Autor:Rafiee M; Dargahi L; Eslami A; Beirami E; Jahangiri-Rad M; Sabour S; Amereh F
[Ad] Endereço:Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Neurobehavioral assessment of rats exposed to pristine polystyrene nanoplastics upon oral exposure.
[So] Source:Chemosphere;193:745-753, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The increasing use of plastics has raised concerns about pollution of freshwater by these polymeric materials. Knowledge about their potential effects on environmental and public health is limited. Recent publications have suggested that the degradation of plastics will result in the release of nano-sized plastic particles to the environment. Therefore, it is of utmost importance to gain knowledge about whether and how nanoplastics affect living organisms. The present study aimed to analyse potential neurobehavioral effects of polystyrene nanoparticles (PS-NPs) after long-term exposure on rat. Potential effects of PS-NPs were investigated using four test dosages (1, 3, 6, and 10 mg PS-NPs/kg of body weight/day) administrated orally with adult Wistar male rats for five weeks. Neurobehavioral tests were chosen to assess a variety of behavioral domains. Particle diameters in test suspensions were determined through dynamic light scattering and showed an average hydrodynamic diameter of approximately 38.92 nm. No statistically significant behavioral effects were observed in all tests performed (p > 0.05). In the elevated plus maze, PS-NPs-exposed rats showed greater number of entries into open arms compared to controls. Also, PS-NPs had no significant influence on body weight of animals. Taking into account the subtle and transient nature of neurobehavioral consequences, however, these results underline the possibility of even pristine plastic nanoparticles to induce behavioral alteration in the rest of the food web, including for marine biota and humans. Indeed even though studied neurobehavioral effects in our study was not statistically significant, the observed subtle effects may be clinically considerable.
[Mh] Termos MeSH primário: Comportamento Animal/efeitos dos fármacos
Poliestirenos/farmacologia
Poluentes Químicos da Água/farmacologia
[Mh] Termos MeSH secundário: Animais
Cadeia Alimentar
Seres Humanos
Masculino
Nanopartículas/efeitos adversos
Nanopartículas/metabolismo
Tamanho da Partícula
Plásticos
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plastics); 0 (Polystyrenes); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  2 / 9447 MEDLINE  
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[PMID]:29406024
[Au] Autor:Ke CY; Lu GM; Sun WJ; Zhang XL
[Ad] Endereço:College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, P.R. China. Electronic address: kcy@xsyu.edu.cn.
[Ti] Título:High efficiency and fast separation of active proteins by HIC chromatographic pie with sub-2 µm polymer packings.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1076:110-116, 2018 Feb 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This paper reports the development of hydrophobic interaction chromatography (HIC) by synthesizing sub-2 µm polymer packings which was packed into a chromatographic pie for fast separation of native proteins at low pressures demonstrating high efficiency. Using styrene as monomer and ethylene dimethacrylate (EDMA)as swelling agent, the polystyrene seeds with an average particle size of 0.8 µm and monodisperse polymeric microspheres with a particle size of 1.5-5.0 µm were synthesized through dispersion polymerization and one-step swelling method, respectively. In order to separate active proteins, the microspheres were modified to hydrophobic chromatographic packings through covalent bonding with benzene methanol. Compared with the traditional column chromatography, the sub-2 µm polymer packings in chromatographic pie exhibited higher column efficiency for protein separation at lower column pressures, even at higher flow rates. The van Deemter curve showed that the flow rate had insignificant effect on column efficiency of chromatographic pie. Seven example proteins were clearly separated within 3 min at a flow rate of 10 mL/min. The applicability of this method was further demonstrated by the separation of human serum samples. The results indicated that this chromatographic mode can be potentially applied for the fast separation of complex active proteins, such as protein drugs from natural products.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/isolamento & purificação
Cromatografia Líquida de Alta Pressão/métodos
[Mh] Termos MeSH secundário: Seres Humanos
Interações Hidrofóbicas e Hidrofílicas
Tamanho da Partícula
Poliestirenos/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Polystyrenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  3 / 9447 MEDLINE  
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[PMID]:29231025
[Au] Autor:Shen X; Li M; Wang YL; Chen YL; Lin Y; Zhao ZM; Que TZ
[Ad] Endereço:Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China.
[Ti] Título:[Comparison of MPure-12 Automatic Nucleic Acid Purification and Chelex-100 Method].
[So] Source:Fa Yi Xue Za Zhi;33(2):168-170, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the forensic application value of MPure-12 automatic nucleic acid purification (MPure-12 Method) for DNA extraction by extracting and typing DNA from bloodstains and various kinds of biological samples with different DNA contents. METHODS: Nine types of biological samples, such as bloodstains, semen stains, and saliva were collected. DNA were extracted using MPure-12 method and Chelex-100 method, followed by PCR amplification and electrophoresis for obtaining STR-profiles. RESULTS: The samples such as hair root, chutty, butt, muscular tissue, saliva stain, bloodstain and semen stain were typed successfully by MPure-12 method. Partial alleles were lacked in the samples of saliva, and the genotyping of contact swabs was unsatisfactory. Additional, all of the bloodstains (20 µL, 15 µL, 10 µL, 5 µL, 1 µL) showed good typing results using Chelex-100 method. But the loss of alleles occurred in 1 µL blood volume by MPure-12 method. CONCLUSIONS: MPure-12 method is suitable for DNA extraction of a certain concentration blood samples.Chelex-100 method may be better for the extraction of trace blood samples.This instrument used in nucleic acid extraction has the advantages of simplicity of operator, rapidity, high extraction efficiency, high rate of reportable STR-profiles and lower man-made pollution.
[Mh] Termos MeSH primário: Quelantes
DNA/isolamento & purificação
Medicina Legal/métodos
Reação em Cadeia da Polimerase/métodos
Poliestirenos
Polivinil
[Mh] Termos MeSH secundário: Alelos
Manchas de Sangue
DNA/sangue
Impressões Digitais de DNA
Genótipo
Seres Humanos
Masculino
Resinas Sintéticas
Saliva
Sêmen/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Polystyrenes); 0 (Polyvinyls); 0 (Resins, Synthetic); 11139-85-8 (Chelex 100); 80208-96-4 (chelex); 9007-49-2 (DNA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.013


  4 / 9447 MEDLINE  
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[PMID]:29235591
[Au] Autor:Chen J; Xu X; Huang Z; Luo Y; Tang L; Jiang JH
[Ad] Endereço:State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China. jianhuijiang@hnu.edu.cn tanglijuang@hnu.edu.cn.
[Ti] Título:BEAMing LAMP: single-molecule capture and on-bead isothermal amplification for digital detection of hepatitis C virus in plasma.
[So] Source:Chem Commun (Camb);54(3):291-294, 2018 Jan 02.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel dNAD platform (BEAMing LAMP) by combining emulsion micro-reactors, single-molecule magnetic capture and on-bead loop-mediated isothermal amplification has been developed for DNA detection, which enables absolute and high-precision quantification of a target with a detection limit of 300 copies.
[Mh] Termos MeSH primário: DNA/sangue
Hepacivirus/isolamento & purificação
Técnicas de Amplificação de Ácido Nucleico/métodos
[Mh] Termos MeSH secundário: Emulsões
Óxido Ferroso-Férrico/química
Fluorescência
Células HeLa
Seres Humanos
Tamanho da Partícula
Plasma
Poliestirenos/química
RNA/sangue
Carga Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 0 (Polystyrenes); 63231-63-0 (RNA); 9007-49-2 (DNA); XM0M87F357 (Ferrosoferric Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1039/c7cc08403j


  5 / 9447 MEDLINE  
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[PMID]:29289927
[Au] Autor:Rajeswari A; Jackcina Stobel Christy E; Pius A
[Ad] Endereço:Department of Chemistry, The Gandhigram Rural Institute - Deemed University, Gandhigram, Dindigul 624 302, Tamil Nadu, India.
[Ti] Título:New insight of hybrid membrane to degrade Congo red and Reactive yellow under sunlight.
[So] Source:J Photochem Photobiol B;179:7-17, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A study was carried out to investigate the degradation of organic contaminants (Congo red and Reactive yellow - 105) using cellulose acetate - polystyrene (CA-PS) membrane with and without ZnO impregnation. Scanning electron microscope (SEM), electron dispersive analysis of X-rays (EDAX), Fourier transform infrared spectrometer (FTIR), atomic force microscope (AFM) and thermogravimeric analysis (TG-DTA) analysis were carried out to characterize bare and ZnO impregnated CA-PS membranes. Membrane efficiency was also tested for pure water flux and antifouling performance. The modified membrane showed almost 85% water flux recovery. Blending of ZnO nanoparticles to CA-PS matrix could decrease membrane fouling and increase permeation quality of the membrane with above 90% of photocatalytic degradation efficiency for dyes. The rate of degradation of dyes was observed using UV-Vis spectrometer. Reusability of CA-PS-ZnO membrane was studied and no significant change was noted in the degradation efficiency until fourth cycle. Langmuir-Hinshelwood kinetic model well describes the photo degradation capacity and the degradation of dyes CR and RY - 105 exhibited pseudo-first order kinetics. The regression coefficient (R) of CR and RY - 105 found to be 0.99. The novelty of the prepared CA-PS-ZnO membrane is that it has better efficiency and high thermal stability than our previously reported material. Therefore, ZnO impregnated CA-PS membrane had proved to be an innovative alternative for the degradation of CR and RY - 105 dyes.
[Mh] Termos MeSH primário: Corantes/química
Vermelho Congo/química
Nanocompostos/química
Fotólise/efeitos da radiação
Luz Solar
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Catálise
Celulose/análogos & derivados
Celulose/química
Microscopia de Força Atômica
Microscopia Eletrônica de Varredura
Poliestirenos/química
Espectrofotometria
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Polystyrenes); 3J2P07GVB6 (acetylcellulose); 3U05FHG59S (Congo Red); 9004-34-6 (Cellulose); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  6 / 9447 MEDLINE  
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[PMID]:29195215
[Au] Autor:Mondal A; De S; Maiti S; Sarkar B; Sk AK; Jacob R; Moorthy A; Paira P
[Ad] Endereço:Department of Chemistry, School of advanced sciences, VIT University, Vellore 632014, India.
[Ti] Título:Amberlite IR-120 (H) mediated "on water" synthesis of fluorescent Ruthenium(II)-arene 8-hydroxyquinoline complexes for cancer therapy and live cell imaging.
[So] Source:J Photochem Photobiol B;178:380-394, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:A series of Ruthenium-Quinolinol complexes (3a-d &4a-d) has been synthesized by employing a simple, efficient and environmental friendly condition. Catalytic role of Amberlite IRA-120(H) has been demonstrated. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of these complexes was measured by UV spectroscopy & time dependent NMR spectroscopy. These newly developed complexes were represented as potential anticancer agent against human breast carcinoma cell line (MCF-7), human Epitheloid Cervix Carcinoma (HeLa), human lung adenocarcinoma epithelial cell line (A549) and human colon cancer cell line (Caco-2). Most of the ruthenium complexes showed higher anticancer activity in MCF-7, HeLa and Caco-2 cell lines than cisplatin. A high selectivity (9-28 folds) was observed with these newly developed organoruthenium compounds in human cancer cell lines (MCF-7, HeLa and Caco-2) with respect to normal fibroblast cell line (MRC-5). Complex [(η6-hexamethylbenzene)RuCl(κ2-O,N-5-chloro-HyQ)]·Cl (4b), [(η6-hexamethylbenzene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (4c) and [(η6-hexamethylbenzene)RuCl(κ2-O,N-5-chloro-7-iodo-HyQ)]·Cl (4d) exhibited best cytotoxicity profiles in three reported human cancer cell lines (MCF-7, HeLa, Caco-2). Cellular imaging study was also performed with these newly developed organoruthenium compounds. Compound 4c might be utilized for cancer theranostic agents because of its significant quantum yield in water, high potency, selectivity and high cellular uptake in cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos/síntese química
Complexos de Coordenação/síntese química
Poliestirenos/química
Rutênio/química
Água/química
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Antineoplásicos/toxicidade
Sítios de Ligação
Células CACO-2
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Complexos de Coordenação/uso terapêutico
Complexos de Coordenação/toxicidade
DNA/química
DNA/metabolismo
Células HeLa
Seres Humanos
Concentração Inibidora 50
Células MCF-7
Neoplasias/tratamento farmacológico
Neoplasias/patologia
Oxiquinolina/química
Ligação Proteica
Soroalbumina Bovina/química
Soroalbumina Bovina/metabolismo
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Coordination Complexes); 0 (Polystyrenes); 059QF0KO0R (Water); 27432CM55Q (Serum Albumin, Bovine); 5UTX5635HP (Oxyquinoline); 7UI0TKC3U5 (Ruthenium); 9002-23-7 (Amberlite IR-120); 9007-49-2 (DNA)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  7 / 9447 MEDLINE  
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[PMID]:29369876
[Au] Autor:Aschenbrenner DS
[Ad] Endereço:Diane S. Aschenbrenner is an assistant professor at Notre Dame of Maryland University in Baltimore. She also coordinates Drug Watch: daschenbrenner@ndm.edu.
[Ti] Título:Potential Drug Interactions with Sodium Polystyrene Sulfonate.
[So] Source:Am J Nurs;118(2):47, 2018 Feb.
[Is] ISSN:1538-7488
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Interações Medicamentosas
Rotulagem de Medicamentos
Poliestirenos/administração & dosagem
Poliestirenos/efeitos adversos
[Mh] Termos MeSH secundário: Quelantes/administração & dosagem
Quelantes/efeitos adversos
Seres Humanos
Hiperpotassemia/tratamento farmacológico
Estados Unidos
United States Food and Drug Administration
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Polystyrenes); 70KO0R01RY (polystyrene sulfonic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM; N
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/01.NAJ.0000530247.38087.3e


  8 / 9447 MEDLINE  
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[PMID]:28461023
[Au] Autor:Ashizawa K; Murata S; Terada T; Ito D; Bunya M; Watanabe K; Teruuchi Y; Tsuchida S; Satoh M; Nishimura M; Matsushita K; Sugama Y; Nomura F
[Ad] Endereço:R&D Department, Nittobo Medical Co., Ltd., 1 Shiojima, Fukuhara, Fukuyama, Koriyama, Fukushima 963-8061, Japan.
[Ti] Título:Applications of copolymer for rapid identification of bacteria in blood culture broths using matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
[So] Source:J Microbiol Methods;139:54-60, 2017 08.
[Is] ISSN:1872-8359
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to identify pathogens in blood culture samples. However, sample pretreatment is needed for direct identification of microbes in blood culture bottles. Conventional protocols are complex and time-consuming. Therefore, in this study, we developed a method for collecting bacteria using polyallylamine-polystyrene copolymer for application in wastewater treatment technology. Using representative bacterial species Escherichia coli and Staphylococcus capitis, we found that polyallylamine-polystyrene can form visible aggregates with bacteria, which can be identified using MALDI-TOF MS. The processing time of our protocol was as short as 15min. Hemoglobin interference in MALDI spectra analysis was significantly decreased in our method compared with the conventional method. In a preliminary experiment, we evaluated the use of our protocol to identify clinical isolates from blood culture bottles. MALDI-TOF MS-based identification of 17 strains from five bacterial species (E. coli, Klebsiella pneumoniae, Enterococcus faecalis, S. aureus, and S. capitis) collected by our protocol was satisfactory. Prospective large-scale studies are needed to further evaluate the clinical application of this novel and simple method of collecting bacteria in blood culture bottles.
[Mh] Termos MeSH primário: Bactérias/classificação
Bactérias/isolamento & purificação
Hemocultura
Polímeros/química
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Infecções Bacterianas/microbiologia
Escherichia coli/isolamento & purificação
Infecções por Escherichia coli/microbiologia
Hemoglobinas/química
Seres Humanos
Poliaminas/química
Poliestirenos/química
Infecções Estafilocócicas/microbiologia
Staphylococcus/classificação
Staphylococcus/isolamento & purificação
Staphylococcus aureus/isolamento & purificação
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hemoglobins); 0 (Polyamines); 0 (Polymers); 0 (Polystyrenes); 30551-89-4 (polyallylamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  9 / 9447 MEDLINE  
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[PMID]:28467596
[Au] Autor:Gilmore J; Islam M; Duncan J; Natu R; Martinez-Duarte R
[Ad] Endereço:Multiscale Manufacturing Laboratory, Department of Mechanical Engineering, Clemson University, Clemson, SC, USA.
[Ti] Título:Assessing the importance of the root mean square (RMS) value of different waveforms to determine the strength of a dielectrophoresis trapping force.
[So] Source:Electrophoresis;38(20):2561-2564, 2017 10.
[Is] ISSN:1522-2683
[Cp] País de publicação:Germany
[La] Idioma:eng
[Mh] Termos MeSH primário: Eletroforese
Modelos Teóricos
[Mh] Termos MeSH secundário: Eletricidade
Microesferas
Poliestirenos
Processamento de Sinais Assistido por Computador
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polystyrenes)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1002/elps.201600551


  10 / 9447 MEDLINE  
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[PMID]:28923687
[Au] Autor:Dominguez Pardo JJ; Dörr JM; Renne MF; Ould-Braham T; Koorengevel MC; van Steenbergen MJ; Killian JA
[Ad] Endereço:Membrane Biochemistry & Biophysics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Padualaan 8, 3584 CH Utrecht, The Netherlands. Electronic address: j.j.dominguezpardo@uu.nl.
[Ti] Título:Thermotropic properties of phosphatidylcholine nanodiscs bounded by styrene-maleic acid copolymers.
[So] Source:Chem Phys Lipids;208:58-64, 2017 Nov.
[Is] ISSN:1873-2941
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Styrene-maleic acid copolymers (SMA) have been gaining interest in the field of membrane research due to their ability to solubilize membranes into nanodics. The SMA molecules act as an amphipathic belt that surrounds the nanodiscs, whereby the hydrophobic styrene moieties can insert in between the lipid acyl chains. Here we used SMA variants with different styrene-to-maleic acid ratio (i.e. 2:1, 3:1 and 4:1) to investigate how lipid packing in the nanodiscs is affected by the presence of the polymers and how it depends on polymer composition. This was done by analyzing the thermotropic properties of a series of saturated phosphatidylcholines in nanodiscs using laurdan fluorescence and differential scanning calorimetry. In all cases it was found that the temperature of the main phase transition (T ) of the lipids in the nanodiscs is downshifted and that its cooperativity is strongly reduced as compared to the situation in vesicles. These effects were least pronounced for lipids in nanodiscs bounded by SMA 2:1. Unexpected trends were observed for the calorimetric enthalpy of the transition, suggesting that the polymer itself contributes, possibly by rearranging around the nanodiscs when the lipids adopt the fluid phase. Finally, distinct differences in morphology were observed for nanodiscs at relatively high polymer concentrations, depending on the SMA variant used. Overall, the results suggest that the extent of preservation of native thermodynamic properties of the lipids as well as the stability of the nanodiscs at high polymer concentrations is better for SMA 2:1 than for the other SMA variants.
[Mh] Termos MeSH primário: Maleatos/química
Nanoestruturas/química
Fosfatidilcolinas/química
Poliestirenos/química
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Maleates); 0 (Phosphatidylcholines); 0 (Polystyrenes); 25300-64-5 (styrene-maleic acid polymer)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE



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