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[PMID]:29175406
[Au] Autor:Sohn SY; Kuntze K; Nijenhuis I; Häggblom MM
[Ad] Endereço:Department of Biochemistry and Microbiology, School of Environmental and Biological Sciences, Rutgers University, 76 Lipman Drive, New Brunswick, NJ 08901, USA.
[Ti] Título:Evaluation of carbon isotope fractionation during anaerobic reductive dehalogenation of chlorinated and brominated benzenes.
[So] Source:Chemosphere;193:785-792, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Compound specific stable isotope analysis (CSIA) has been established as a useful tool to evaluate in situ biodegradation. Here, CSIA was used to determine microbial dehalogenation of chloro- and bromobenzenes in microcosms derived from Hackensack River sediments. Gas chromatography-isotope ratio mass spectrometry (GC-IRMS) was used to measure carbon isotope fractionation during reductive dehalogenation of hexachlorobenzene (HCB), pentachlorobenzene (PeCB), 1,2,3,5-tetrachlorobenzene (TeCB), 1,2,3,5-tetrabromobenzene (TeBB), and 1,3,5-tribromobenzene (TriBB). Strong evidence of isotope fractionation coupled to dehalogenation was not observed in the substrate, possibly due to the low solubilities of the highly halogenated benzene substrates and a dilution of the isotope signal. Nonetheless, we could measure a depletion of the δ C value in the dichlorobenzene product during dechlorination of HCB, the sequential depletion and enrichment of δ C value for trichlorobenzene in TeCB dechlorinating cultures, and the enrichment of δ C during debromination of TriBB. This indicates that a measurable isotope fractionation occurred during reductive dehalogenation of highly halogenated chloro- and bromobenzenes in aquatic sediments. Thus, although more quantitative measurements will be needed, the data suggests that CSIA may have application for monitoring in situ microbial reductive dehalogenation of highly halogenated benzenes.
[Mh] Termos MeSH primário: Benzeno
Biodegradação Ambiental
Bromobenzenos/metabolismo
Fracionamento Químico
Clorobenzenos/metabolismo
[Mh] Termos MeSH secundário: Bromobenzenos/análise
Isótopos de Carbono/química
Clorobenzenos/análise
Monitoramento Ambiental/métodos
Cromatografia Gasosa-Espectrometria de Massas
Halogenação
Rios/química
Rios/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bromobenzenes); 0 (Carbon Isotopes); 0 (Chlorobenzenes); J64922108F (Benzene)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28456299
[Au] Autor:Li J; Kang T; Talab KMA; Zhu F; Li J
[Ad] Endereço:College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
[Ti] Título:Molecular and biochemical characterization of dimethachlone resistant isolates of Sclerotinia sclerotiorum.
[So] Source:Pestic Biochem Physiol;138:15-21, 2017 May.
[Is] ISSN:1095-9939
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sclerotinia sclerotiorum is a necrotrophic fungal plant pathogen with a broad host range. The dicarboximide fungicide dimethachlone has been used to control this pathogen for more than a decade and resistance to dimethachlone has recently been reported in China. Compared with sensitive isolates, the three dimethachlone resistant isolates with resistance ratios of 78.3, 85.5, and 94.8 exhibited significantly (P<0.05) higher cell membrane permeability and peroxidase and polyphenol oxidase activities. Dimethachlone at 0.25µg/mL significantly increased cell membrane permeability and enhanced activity of the two enzymes in both resistant and sensitive isolates. There were no significant differences in glycerol or oxalate content between the resistant and sensitive isolates. Dimethachlone treatment increased glycerol content in the resistant isolates and reduced in the sensitive isolates (P<0.01). Sequencing of three genes involved in two-component signal pathway and of three genes in mitogen-activated protein (MAP) kinase cascade demonstrated that the dimethachlone resistant isolates HLJ4 and HLJ6 harbored point mutations of I232T and G1087D, respectively, in the deduce amino acid sequence of the histidine kinase (HK) gene Sshk. HLJ4 had a point mutation of P96L in the deduced amino acid sequence of the MAP kinase-kinase gene SsPbs. The expression levels of the Sshk gene were higher in HLJ4 and HLJ6 than in HLJ3 and the sensitive isolate HLJMG2, and transcription of the Sshk gene was up-regulated by dimethachlone for the three resistant isolates.
[Mh] Termos MeSH primário: Ascomicetos/efeitos dos fármacos
Clorobenzenos/farmacologia
Farmacorresistência Fúngica
Fungicidas Industriais/farmacologia
Succinimidas/farmacologia
[Mh] Termos MeSH secundário: Sequência de Bases
Catecol Oxidase/genética
Catecol Oxidase/metabolismo
Clonagem Molecular
Proteínas Fúngicas/genética
Proteínas Fúngicas/metabolismo
Regulação Enzimológica da Expressão Gênica
Regulação Fúngica da Expressão Gênica
Mutação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 0 (Fungal Proteins); 0 (Fungicides, Industrial); 0 (Succinimides); 0 (dimethachlon); EC 1.10.3.1 (Catechol Oxidase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29072707
[Au] Autor:Britton J; Jamison TF
[Ad] Endereço:Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
[Ti] Título:The assembly and use of continuous flow systems for chemical synthesis.
[So] Source:Nat Protoc;12(11):2423-2446, 2017 Nov.
[Is] ISSN:1750-2799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The adoption of and opportunities in continuous flow synthesis ('flow chemistry') have increased significantly over the past several years. Continuous flow systems provide improved reaction safety and accelerated reaction kinetics, and have synthesised several active pharmaceutical ingredients in automated reconfigurable systems. Although continuous flow platforms are commercially available, systems constructed 'in-lab' provide researchers with a flexible, versatile, and cost-effective alternative. Herein, we describe the assembly and use of a modular continuous flow apparatus from readily available and affordable parts in as little as 30 min. Once assembled, the synthesis of a sulfonamide by reacting 4-chlorobenzenesulfonyl chloride with dibenzylamine in a single reactor coil with an in-line quench is presented. This example reaction offers the opportunity to learn several important skills including reactor construction, charging of a back-pressure regulator, assembly of stainless-steel syringes, assembly of a continuous flow system with multiple junctions, and yield determination. From our extensive experience of single-step and multistep continuous flow synthesis, we also describe solutions to commonly encountered technical problems such as precipitation of solids ('clogging') and reactor failure. Following this protocol, a nonspecialist can assemble a continuous flow system from reactor coils, syringes, pumps, in-line liquid-liquid separators, drying columns, back-pressure regulators, static mixers, and packed-bed reactors.
[Mh] Termos MeSH primário: Técnicas de Química Sintética/instrumentação
Reologia/instrumentação
Sulfonamidas/síntese química
[Mh] Termos MeSH secundário: Benzilaminas/química
Técnicas de Química Sintética/métodos
Clorobenzenos/química
Cinética
Reologia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzylamines); 0 (Chlorobenzenes); 0 (Sulfonamides); 3G0YFX01C6 (dibenzylamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171027
[St] Status:MEDLINE
[do] DOI:10.1038/nprot.2017.102


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[PMID]:28772354
[Au] Autor:Pei G; Zhu Y; Cai X; Shi W; Li H
[Ad] Endereço:School of Environment Science and Resources, Shanxi University, Taiyuan, Shanxi 030006, China; Institute of Resources and Environment Engineering, Shanxi University, Taiyuan, Shanxi 030006, China.
[Ti] Título:Surfactant flushing remediation of o-dichlorobenzene and p-dichlorobenzene contaminated soil.
[So] Source:Chemosphere;185:1112-1121, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Surfactant-enhanced remediation is used to treat dichlorobenzene (DCB) contaminated soil. In this study, soil column experiments were conducted to investigate the removal efficiencies of o-dichlorobenzene (o-DCB) and p-dichlorobenzene (p-DCB) from contaminated soil using micellar solutions of biosurfactants (saponin, alkyl polyglycoside) compare to a chemically synthetic surfactant (Tween 80). Leachate was collected and analyzed for o-DCB and p-DCB content. In addition, soil was analyzed to explore the effect of surfactants on soil enzyme activities. Results showed that the removal efficiency of o-DCB and p-DCB was highest for saponin followed by alkyl polyglycoside and Tween 80. The maximum o-DCB and p-DCB removal efficiencies of 76.34% and 80.43%, respectively, were achieved with 4 g L saponin solution. However, an opposite result was observed in the cumulative mass of o-DCB and p-DCB in leachate. The cumulative extent of o-DCB and p-DCB removal by the biosurfactants saponin and alkyl polyglycoside was lower than that of the chemically synthetic surfactant Tween 80 in leachate. Soil was also analyzed to explore the effect of surfactants on soil enzyme activities. The results indicated that surfactants were potentially effective in facilitating soil enzyme activities. Thus, it was confirmed that the biosurfactants saponin and alkyl polyglycoside could be used for remediation of o-DCB and p-DCB contaminated soil.
[Mh] Termos MeSH primário: Clorobenzenos/análise
Recuperação e Remediação Ambiental/métodos
Poluentes do Solo/análise
Tensoativos/química
[Mh] Termos MeSH secundário: Clorobenzenos/química
Poluição Ambiental/estatística & dados numéricos
Micelas
Polissorbatos
Solo/química
Poluentes do Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 0 (Micelles); 0 (Polysorbates); 0 (Soil); 0 (Soil Pollutants); 0 (Surface-Active Agents); 6PJ93I88XL (2-dichlorobenzene); D149TYB5MK (4-dichlorobenzene); K18102WN1G (chlorobenzene)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28541143
[Au] Autor:Moss MJ; Maskell KF; Hieger MA; Wills BK; Cumpston KL
[Ad] Endereço:a Department of Emergency Medicine , VCU Medical Center , Richmond , VA , USA.
[Ti] Título:An algorithm for identifying mothball composition .
[So] Source:Clin Toxicol (Phila);55(8):919-921, 2017 Sep.
[Is] ISSN:1556-9519
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Unintentional mothball ingestions may cause serious toxicity in small children. Camphor, naphthalene, and paradichlorobenzene mothballs are difficult to distinguish without packaging. Symptoms and management differ based on the ingested compound. Previous studies have used a variety of antiquated, impractical and potentially dangerous techniques to identify the mothballs. The goal of this study is to discover a simplified identification technique using materials readily available in an emergency department. METHODS: Mothballs made of naphthalene and paradichlorobenzene along with camphor tablets were tested. Each material was tested both intact and after being fragmented to simulate a partially ingested mothball. Each of these six sample types were then immersed in 40 ml each of 11 fluids: water, 0.45% NaCl, 0.9% NaCl, lactated Ringer's, 5% dextrose in water, 5% dextrose in 0.9% NaCl, 50% dextrose in water, 8.4% NaHCO , 3% H O , 70% isopropanol, and 91% isopropanol. All tests were conducted in standard urinalysis sample cups to replicate available materials. Three toxicologists blinded to the identities of samples and solutions visually evaluated each sample. Observations included assessing response to immersion: sink, float, or dissolve. RESULTS: All evaluators agreed in their description of 62/66 (94%) of the samples, with all four disagreements being on sinking and dissolving versus sinking only. A two-fluid algorithm utilizing 50% dextrose and water was sufficient to distinguish the sample types. Camphor will float in water while both paradichlorobenzene and naphthalene will sink. In 50% dextrose, both naphthalene and camphor will float while paradichlorobenzene will sink. CONCLUSION: Mothball materials can be distinguished by immersion in water and 50% dextrose. Limitations of this study include using camphor tablets as a substitute for mothballs given lack of availability.
[Mh] Termos MeSH primário: Algoritmos
Cânfora/análise
Clorobenzenos/análise
Glucose/química
Repelentes de Insetos/análise
Mariposas
Naftalenos/análise
Água/química
[Mh] Termos MeSH secundário: Animais
Cânfora/envenenamento
Clorobenzenos/envenenamento
Liberação Controlada de Fármacos
Repelentes de Insetos/envenenamento
Naftalenos/envenenamento
Variações Dependentes do Observador
Reprodutibilidade dos Testes
Solubilidade
Gravidade Específica
Comprimidos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 0 (Insect Repellents); 0 (Naphthalenes); 0 (Tablets); 059QF0KO0R (Water); 2166IN72UN (naphthalene); 76-22-2 (Camphor); D149TYB5MK (4-dichlorobenzene); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1080/15563650.2017.1319954


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[PMID]:28500989
[Au] Autor:Lhotský O; Krákorová E; Masín P; Zebrák R; Linhartová L; Kresinová Z; Kaslík J; Steinová J; Rødsand T; Filipová A; Petru K; Kroupová K; Cajthaml T
[Ad] Endereço:DEKONTA a.s., Volutová 2523, CZ-158 00, Prague 5, Czech Republic; Institute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, CZ-128 01, Prague 2, Czech Republic.
[Ti] Título:Pharmaceuticals, benzene, toluene and chlorobenzene removal from contaminated groundwater by combined UV/H O photo-oxidation and aeration.
[So] Source:Water Res;120:245-255, 2017 Sep 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was performed to test the feasibility of several decontamination methods for remediating heavily contaminated groundwater in a real contaminated locality in the Czech Republic, where a pharmaceuticals plant has been in operation for more than 80 years. The site is polluted mainly by recalcitrant psychopharmaceuticals and monoaromatic hydrocarbons, such as benzene, toluene and chlorobenzene. For this purpose, an advanced oxidation technique employing UV radiation with hydrogen peroxide dosing was employed, in combination with simple aeration pretreatment. The results showed that UV/H O was an efficient and necessary step for degradation of the pharmaceuticals; however, the monoaromatics were already removed during the aeration step. Characterization of the removal mechanisms participating in the aeration revealed that volatilization, co-precipitation and biodegradation contributed to the process. These findings were supported by bacterial metabolite analyses, phospholipid fatty acid analysis, qPCR of representatives of the degradative genes and detailed characterization of the formed precipitate using Mössbauer spectroscopy and scanning electron microscopy. Further tests were carried out in a continuous arrangement directly connected to the wells already present in the locality. The results documented the feasibility of combination of the photo-reactor employing UV/H O together with aeration pretreatment for 4 months, where the overall decontamination efficiency ranged from 72% to 99% of the pharmaceuticals. We recorded even better results for the monoaromatics decontamination except for one month, when we encountered some technical problems with the aeration pump. This demonstrated the necessity of using the aeration step.
[Mh] Termos MeSH primário: Poluição Ambiental/prevenção & controle
Água Subterrânea
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Benzeno
Biodegradação Ambiental
Clorobenzenos
República Tcheca
Peróxido de Hidrogênio
Preparações Farmacêuticas
Tolueno
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 0 (Pharmaceutical Preparations); 0 (Water Pollutants, Chemical); 3FPU23BG52 (Toluene); BBX060AN9V (Hydrogen Peroxide); J64922108F (Benzene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


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[PMID]:28477821
[Au] Autor:Jiang L; Nie G; Zhu R; Wang J; Chen J; Mao Y; Cheng Z; Anderson WA
[Ad] Endereço:College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address: jiangly@zjut.edu.cn.
[Ti] Título:Efficient degradation of chlorobenzene in a non-thermal plasma catalytic reactor supported on CeO /HZSM-5 catalysts.
[So] Source:J Environ Sci (China);55:266-273, 2017 May.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chlorobenzene removal was investigated in a non-thermal plasma reactor using CeO /HZSM-5 catalysts. The performance of catalysts was evaluated in terms of removal and energy efficiency. The decomposition products of chlorobenzene were analyzed. The results show that CeO /HZSM-5 exhibited a good catalytic activity, which resulted in enhancements of chlorobenzene removal, energy efficiency, and the formation of lower amounts of by-products. With regards to CO selectivity, the presence of catalysts favors the oxidation of by-products, leading to a higher CO selectivity. With respect to ozone, which is considered as an unavoidable by-product in air plasma reactors, a noticeable decrease in its concentration was observed in the presence of catalysts. Furthermore, the stability of the catalyst was investigated by analyzing the evolution of conversion in time. The experiment results indicated that CeO /HZSM-5 catalysts have excellent stability: chlorobenzene conversion only decreased from 78% to 60% after 75hr, which means that the CeO /HZSM-5 suffered a slight deactivation. Some organic compounds and chlorinated intermediates were adsorbed or deposited on the catalysts surface as shown by the results of Fourier Transform Infrared (FT-IR) spectroscopy, scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDS) analyses of the catalyst before and after the reaction, revealing the cause of catalyst deactivation.
[Mh] Termos MeSH primário: Cério/química
Clorobenzenos/química
Modelos Químicos
Zeolitas/química
[Mh] Termos MeSH secundário: Adsorção
Catálise
Oxirredução
Espectrometria por Raios X
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorobenzenes); 1318-02-1 (Zeolites); 30K4522N6T (Cerium); 619G5K328Y (ceric oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


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[PMID]:28416587
[Au] Autor:Brook RD; Anderson JA; Calverley PM; Celli BR; Crim C; Denvir MA; Magder S; Martinez FJ; Rajagopalan S; Vestbo J; Yates J; Newby DE; SUMMIT Investigators
[Ad] Endereço:Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
[Ti] Título:Cardiovascular outcomes with an inhaled beta2-agonist/corticosteroid in patients with COPD at high cardiovascular risk.
[So] Source:Heart;103(19):1536-1542, 2017 Oct.
[Is] ISSN:1468-201X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD) often coexist. We assessed the effect of inhaled COPD treatments on CVD outcomes and safety in patients with COPD and at heightened CVD risk. METHODS: The SUMMIT (Study to Understand Mortality and MorbidITy) was a multicentre, randomised, double-blind, placebo-controlled, event-driven trial in 16 485 patients with moderate COPD who had or were at high risk of CVD. Here, we assessed the prespecified secondary endpoint of time to first on-treatment composite CVD event (CVD death, myocardial infarction, stroke, unstable angina or transient ischaemic attack (TIA)) by Cox regression and by clinician-reported CVD adverse events across the four groups: once-daily inhaled placebo (n=4111), long-acting beta -agonist (vilanterol (VI) 25 µg; n=4118), corticosteroid (fluticasone furoate (FF) 100 µg; n=4135) and combination therapy (FF/VI; n=4121). RESULTS: Participants were predominantly middle-aged (mean 65 (SD 8) years) men (75%) with overt CVD (66%). The composite CVD endpoint occurred in 688 patients (first event: sudden death (35%), acute coronary syndrome (37%) and stroke or TIA (23%), and was not reduced in any treatment group versus placebo: VI (HR 0.99, 95% CI 0.80 to 1.22), FF (HR 0.90, 95% CI 0.72 to 1.11) and their combination (HR 0.93, 95% CI 0.75 to 1.14). Outcomes were similar among all subgroups. Adverse events, including palpitations and arrhythmias, did not differ by treatment. CONCLUSIONS: In patients with COPD with moderate airflow limitation and heightened CVD risk, treatment with inhaled VI, FF or their combination has an excellent safety profile and does not impact CVD outcomes. TRIAL REGISTRATION NUMBER: NCT01313676.
[Mh] Termos MeSH primário: Androstadienos/administração & dosagem
Álcoois Benzílicos/administração & dosagem
Doenças Cardiovasculares/tratamento farmacológico
Clorobenzenos/administração & dosagem
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração por Inalação
Antagonistas de Receptores Adrenérgicos beta 2/administração & dosagem
Adulto
Idoso
Idoso de 80 Anos ou mais
Doenças Cardiovasculares/etiologia
Doenças Cardiovasculares/fisiopatologia
Relação Dose-Resposta a Droga
Método Duplo-Cego
Combinação de Medicamentos
Feminino
Seguimentos
Volume Expiratório Forçado
Glucocorticoides/administração & dosagem
Seres Humanos
Masculino
Meia-Idade
Doença Pulmonar Obstrutiva Crônica/complicações
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Fatores de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Adrenergic beta-2 Receptor Antagonists); 0 (Androstadienes); 0 (Benzyl Alcohols); 0 (Chlorobenzenes); 0 (Drug Combinations); 0 (Glucocorticoids); 028LZY775B (vilanterol); JS86977WNV (fluticasone furoate)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170419
[St] Status:MEDLINE
[do] DOI:10.1136/heartjnl-2016-310897


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[PMID]:28392684
[Au] Autor:Wilson MR; Patel JG; Coleman A; McDade CL; Stanford RH; Earnshaw SR
[Ad] Endereço:RTI Health Solutions, Research Triangle Park, NC, USA.
[Ti] Título:Cost-effectiveness analysis of umeclidinium/vilanterol for the management of patients with moderate to very severe COPD using an economic model.
[So] Source:Int J Chron Obstruct Pulmon Dis;12:997-1008, 2017.
[Is] ISSN:1178-2005
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bronchodilators such as long-acting muscarinic antagonists (LAMAs) and long-acting ß -agonists (LABAs) are central to the pharmacological management of COPD. Dual bronchodilation with umeclidinium/vilanterol (UMEC/VI; 62.5/25 µg) is a novel LAMA/LABA combination approved for maintenance treatment for patients with COPD. OBJECTIVE: The objective of this study was to assess the cost-effectiveness of maintenance treatment with UMEC/VI compared with tiotropium (TIO) 18 µg, open dual LAMA + LABA treatment, or no long-acting bronchodilator treatment in patients with moderate to very severe COPD. METHODS: A Markov model was developed to estimate the costs and outcomes associated with UMEC/VI treatment in patients with moderate to very severe COPD (GSK study number: HO-13-13411). Clinical efficacy, costs, utilities, and mortality obtained from the published literature were used as the model inputs. Costs are presented in US dollars based on 2015 prices. The model outputs are total costs, drug costs, other medical costs, number of COPD exacerbations, and quality-adjusted life-years (QALYs). Costs and outcomes were discounted at a 3% annual rate. Incremental cost-effectiveness ratios were calculated. One-way and probabilistic sensitivity analyses were conducted to assess the effects of changing parameters on the uncertainty of the results. RESULTS: UMEC/VI treatment for moderate to very severe COPD was associated with lower lifetime medical costs ($82,344) compared with TIO ($88,822), open dual LAMA + LABA treatment ($114,442), and no long-acting bronchodilator ($86,751). Fewer exacerbations were predicted to occur with UMEC/VI treatment compared with no long-acting bronchodilator treatment. UMEC/VI provided an 0.11 and 0.25 increase in QALYs compared with TIO and no long-acting bronchodilator treatment, and as such, dominated these cost-effectiveness analyses. Sensitivity analyses confirmed that the results were robust. CONCLUSION: The results from this model suggest that UMEC/VI treatment would be dominant compared with TIO and no long-acting bronchodilator treatment, and less costly than open dual LAMA + LABA treatment in patients with moderate to very severe COPD.
[Mh] Termos MeSH primário: Agonistas de Receptores Adrenérgicos beta 2/administração & dosagem
Agonistas de Receptores Adrenérgicos beta 2/economia
Álcoois Benzílicos/administração & dosagem
Álcoois Benzílicos/economia
Broncodilatadores/administração & dosagem
Broncodilatadores/economia
Clorobenzenos/administração & dosagem
Clorobenzenos/economia
Custos de Medicamentos
Modelos Econômicos
Antagonistas Muscarínicos/administração & dosagem
Antagonistas Muscarínicos/economia
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
Doença Pulmonar Obstrutiva Crônica/economia
Quinuclidinas/administração & dosagem
Quinuclidinas/economia
[Mh] Termos MeSH secundário: Administração por Inalação
Agonistas de Receptores Adrenérgicos beta 2/efeitos adversos
Álcoois Benzílicos/efeitos adversos
Broncodilatadores/efeitos adversos
Clorobenzenos/efeitos adversos
Análise Custo-Benefício
Combinação de Medicamentos
Seres Humanos
Cadeias de Markov
Antagonistas Muscarínicos/efeitos adversos
Doença Pulmonar Obstrutiva Crônica/diagnóstico
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
Anos de Vida Ajustados por Qualidade de Vida
Quinuclidinas/efeitos adversos
Índice de Gravidade de Doença
Fatores de Tempo
Brometo de Tiotrópio/administração & dosagem
Brometo de Tiotrópio/economia
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-2 Receptor Agonists); 0 (Benzyl Alcohols); 0 (Bronchodilator Agents); 0 (Chlorobenzenes); 0 (Drug Combinations); 0 (GSK573719); 0 (Muscarinic Antagonists); 0 (Quinuclidines); 028LZY775B (vilanterol); XX112XZP0J (Tiotropium Bromide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.2147/COPD.S124420


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[PMID]:28377163
[Au] Autor:Qu Q; Xuan H; Zhang K; Chen X; Sun S; Ding Y; Feng S; Xu Q
[Ad] Endereço:Key Laboratory of Functional Molecule Design and Interface Process, School of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei 230601, China. Electronic address: quqishu@qq.com.
[Ti] Título:Rods-on-sphere silica particles for high performance liquid chromatography.
[So] Source:J Chromatogr A;1497:87-91, 2017 May 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Silica spheres covered with rods perpendicular to the particle surface were prepared by a simple one-pot sol-gel process. Thus prepared rods-on-sphere silica particles possessed core-shell structure. Compared to other core-shell silica particles in which the shell was synthesized by the time-consuming multiple-step layer-by-layer coating technique, the shell of our rods-on-sphere particles was formed by directly grown rods from the silica spheres. The coverage of the rods on the particle surface could be tuned by changing the amount of water in the reaction. The rods on the particle surface increased the surface roughness which may help decreasing the A-term. Therefore, the calcined and modified rods-on-sphere silica particles were packed into stainless steel columns and then assessed for the separation of various samples including small molecules and proteins. In comparison with a commercially available Kromasil column, the pressure of the rods-on-sphere column is much lower under the same separation conditions, while the column efficiency was comparable. The separation results demonstrate that rods-on-sphere silica particles are a type of new and highly promising packing stationary phase for high performance liquid chromatography.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Dióxido de Silício/química
[Mh] Termos MeSH secundário: Compostos de Anilina/análise
Compostos de Anilina/isolamento & purificação
Clorobenzenos/análise
Clorobenzenos/isolamento & purificação
Naftalenos/análise
Naftalenos/isolamento & purificação
Tamanho da Partícula
Proteínas/química
Proteínas/isolamento & purificação
Propriedades de Superfície
Teofilina/análise
Teofilina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Chlorobenzenes); 0 (Naphthalenes); 0 (Proteins); 2166IN72UN (naphthalene); 29757-24-2 (nitroaniline); 6PJ93I88XL (2-dichlorobenzene); 7631-86-9 (Silicon Dioxide); C137DTR5RG (Theophylline)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE



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