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Pesquisa : D02.455.426.559.389.454.950 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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Fotocópia
[PMID]:3791669
[Au] Autor:Noguchi K; Suzuki H; Nakahata M; Kurosawa S; Nakagawa S
[Ti] Título:Prolonged treatment of hyperthyroidism with sodium tyropanoate, an oral cholecystographic agent: a re-evaluation of its clinical utility.
[So] Source:Clin Endocrinol (Oxf);25(3):293-301, 1986 Sep.
[Is] ISSN:0300-0664
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To re-evaluate the clinical utility of the prolonged management of hyperthyroidism with sodium tyropanoate (TP), an oral cholecystographic agent, we studied the changes in the scoring of thyrotoxic signs and symptoms (thyrotoxic index; TI), serum concentrations and binding of thyroid hormone, and circulating TSH receptor antibodies (TRAb) in two groups of patients with Graves' disease; seven patients (TP group) received TP (1.5 g daily) alone for 14 weeks, and six patients (TP + MMI group) received methimazole (MMI; 30 mg daily) in addition to TP for 8 weeks and MMI alone thereafter. In the TP group, the TI reduced significantly, but it failed to reach a euthyroid level in all except one. Serum total T4 (TT4), free T4 (FT4), and T3 uptake (T3U) values declined by the third week of treatment, but an 'escape' occurred thereafter. Serum rT3 and T4 binding globulin (TBG) levels were increased. The TRAb titres were increased slightly but significantly. Serum T3 levels fell within a week but remained higher than normal during the treatment. In the TP + MMI group, all patients achieved a normal TI by the end of the treatment. Serum TT4, FT4 and T3U fell more significantly than those in the TP group, indicating no escape from the effect of TP. The serum TRAb decreased significantly. Serum T3 levels showed a greater reduction than those in the TP group, and remained decreased even after withdrawal of TP. In a further 9 patients receiving TP alone for 4-14 weeks (7.3 +/- 5.0 weeks on the average), TP was withdrawn and replaced by MMI.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Doença de Graves/tratamento farmacológico
Iodobenzenos/uso terapêutico
Tiropanoato/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Quimioterapia Combinada
Feminino
Doença de Graves/sangue
Seres Humanos
Masculino
Metimazol/uso terapêutico
Meia-Idade
Hormônios Tireóideos/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodobenzenes); 0 (Thyroid Hormones); 4F05V145YR (Tyropanoate); 554Z48XN5E (Methimazole)
[Em] Mês de entrada:8702
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860901
[St] Status:MEDLINE


  2 / 27 MEDLINE  
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Fotocópia
[PMID]:3698921
[Au] Autor:Felicetta JV; Czanko R; Huber-Smith MJ; McCann DS
[Ti] Título:Cholecystographic agents and sulfobromophthalein inhibit the binding of L-thyroxine to plasma membranes of rat hepatocytes.
[So] Source:Endocrinology;118(6):2500-4, 1986 Jun.
[Is] ISSN:0013-7227
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cholecystographic agents and sulfobromophthalein (BSP) cause a major discharge of labeled T4 from the liver in man in vivo. In the present study we sought to determine if this discharge is partially due to inhibition of T4 binding to plasma membrane sites. Plasma membranes were isolated from hepatocytes of female Sprague-Dawley rats, and 5'-nucleotidase levels were measured to demonstrate plasma membrane viability. Specific binding of T4 (Ka, 1.01 X 10(8) M) was confirmed by displacement of labeled T4 by unlabeled hormone (10(-10)-10(-5) M). Displacement of labeled hormone was also produced by addition of tyropanoate, iopanoate, ipodate, or BSP. At 5-mM concentrations of inhibitor, the Ka for T4 declined to 4.00 X 10(7) M with BSP, 5.07 X 10(7) M with ipodate, 5.62 X 10(7) M with tyropanoate, and 7.43 X 10(7) M with iopanoate. Thus, a portion of the discharge of hepatic T4 after administration of these agents may be due to competitive inhibition of binding to plasma membrane sites.
[Mh] Termos MeSH primário: Meios de Contraste/farmacologia
Fígado/metabolismo
Sulfobromoftaleína/farmacologia
Tiroxina/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Ligação Competitiva
Membrana Celular/metabolismo
Colecistografia
Feminino
Ácido Iopanoico/farmacologia
Ipodato/farmacologia
Fígado/efeitos dos fármacos
Ratos
Ratos Endogâmicos
Tiroxina/metabolismo
Tiropanoato/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 0C2P5QKL36 (Sulfobromophthalein); 4F05V145YR (Tyropanoate); F604ZKI910 (Ipodate); FE9794P71J (Iopanoic Acid); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:8606
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:860601
[St] Status:MEDLINE


  3 / 27 MEDLINE  
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Fotocópia
[PMID]:6706718
[Au] Autor:Fiske SA; Stamper DW
[Ti] Título:The use of calcium Oragrafin granules in repeat cholecystography, with supplemental ultrasonographic evaluation.
[So] Source:J Am Osteopath Assoc;83(7):512-5, 1984 Mar.
[Is] ISSN:0098-6151
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Cálcio
Colecistografia/métodos
Doenças da Vesícula Biliar/diagnóstico por imagem
Ipodato
Ultrassonografia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Feminino
Doenças da Vesícula Biliar/diagnóstico
Seres Humanos
Masculino
Meia-Idade
Tiropanoato
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
4F05V145YR (Tyropanoate); F604ZKI910 (Ipodate); SY7Q814VUP (Calcium)
[Em] Mês de entrada:8405
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:840301
[St] Status:MEDLINE


  4 / 27 MEDLINE  
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Fotocópia
[PMID]:6853679
[Au] Autor:Felicetta JV; Green WL; Huber-Smith MJ
[Ti] Título:Effects of cholecystographic agents and sulfobromophthalein on binding of thyroid hormones to serum proteins.
[So] Source:J Clin Endocrinol Metab;57(1):207-12, 1983 Jul.
[Is] ISSN:0021-972X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A number of interactions between thyroid hormones and cholecystographic agents have previously been demonstrated. In the present study we show that cholecystographic agents also interfere with the binding of thyroid hormones to serum proteins. A commercial kit (Tri-Tab) was used in which the uptake of labeled hormone from serum by a silicate adsorbent tablet is measured. In the presence of cholecystographic agents or sulfobromophthalein (BSP), the amount of labeled hormone bound to adsorbent increased in a dose-dependent fashion, reflecting displacement from protein-binding sites. The order of potency was BSP greater than ipodate greater than iopanoate greater than tyropanoate. Displacement of hormone was confirmed by a second methodology in which graded amounts of unlabeled T4 were added to the system. This allowed a Scatchard analysis to be performed for binding sites on T4-binding globulin. The cholecystographic agents and BSP caused displacement of the Scatchard slopes, again demonstrating interference with binding to serum protein sites. A method is described in which the change in Scatchard slope produced by an inhibitor is employed to compute the association constant between T4-binding sites on T4-binding globulin and the inhibitors. The values were: BSP, 14.6 X 10(3) M-1; ipodate, 4.7 X 10(3) M-1, iopanoate, 2.2 X 10(3) M-1; and tyropanoate, 0.1 X 10(3) M-1. Because of these relatively low values and the rapidity with which these agents are normally cleared from serum, it seems likely that effects on free hormone levels would be transient and of small magnitude during routine cholecystography. Also, ipodate, in the 1 g/day dose that has been employed experimentally to treat hyperthyroidism, should have a negligible effect on protein binding. On the other hand, when high levels of these compounds are used in experimental settings to study other aspects of thyroid hormone metabolism, changes in protein binding can occur and confound interpretation of results.
[Mh] Termos MeSH primário: Proteínas Sanguíneas/metabolismo
Meios de Contraste/farmacologia
Sulfobromoftaleína/farmacologia
Tiroxina/sangue
Tri-Iodotironina/sangue
[Mh] Termos MeSH secundário: Seres Humanos
Técnicas In Vitro
Ácido Iopanoico/farmacologia
Ipodato/farmacologia
Cinética
Masculino
Ligação Proteica/efeitos dos fármacos
Tiropanoato/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Proteins); 0 (Contrast Media); 06LU7C9H1V (Triiodothyronine); 0C2P5QKL36 (Sulfobromophthalein); 4F05V145YR (Tyropanoate); F604ZKI910 (Ipodate); FE9794P71J (Iopanoic Acid); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:8307
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:830701
[St] Status:MEDLINE


  5 / 27 MEDLINE  
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Fotocópia
[PMID]:6618819
[Au] Autor:Cooke WJ; Cooke LM
[Ti] Título:Biliary and urinary excretion of tyropanoic acid and its Metabolites in the dog.
[So] Source:Invest Radiol;18(3):285-92, 1983 May-Jun.
[Is] ISSN:0020-9996
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The biliary and urinary excretion of tyropanoate-derived material was studied in the anesthetized dog with various plasma levels of tyropanoate. Bile, plasma, urine, and hepatic tissue were analyzed by high-pressure liquid chromatography for the presence of tyropanoate, enantiomers of tyropanoate glucuronide, and other typropanoate metabolites. Approximately 90% of the material secreted in the bile was in the form of tyropanoate glucuronide, equally distributed between (+)- and(-)-tyropanoate glucuronide, and approximately 10% was excreted as other tyropanoate-derived metabolites. It is suggested that the choleretic effect associated with the excretion of tyropanoate is associated with the nonglucuronide metabolites. Tyropanoate itself was not secreted into bile. In plasma, approximately 40% of the material was tyropanoate, while approximately 50% existed as tyropanoate glucuronide and 10% as other tyropanoate metabolites. The plasma concentration of (-)-tyropanoate glucuronide was significantly greater than that of (+)-tyropanoate glucuronide. The urinary excretion of tyropanoate-derived material accounted for up to 35% of the total excretion. The primary metabolite in urine was tyropanoate glucuronide. Tyropanoate accounted for less than 5% of the material in urine, whereas other tyropanoate metabolites contributed approximately 20%. The data suggest that there is a stereoselective disposition of tyropanoate metabolites that may influence the overall disposition of the compound.
[Mh] Termos MeSH primário: Bile/metabolismo
Iodobenzenos/metabolismo
Tiropanoato/metabolismo
[Mh] Termos MeSH secundário: Animais
Biotransformação
Cães
Fígado/metabolismo
Tiropanoato/análogos & derivados
Tiropanoato/sangue
Tiropanoato/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Iodobenzenes); 0 (tyropanoate glucuronide); 4F05V145YR (Tyropanoate)
[Em] Mês de entrada:8311
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:830501
[St] Status:MEDLINE


  6 / 27 MEDLINE  
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Fotocópia
[PMID]:7156610
[Au] Autor:Ipinza I
[Ti] Título:[Clinico-radiological study of 3 radiopaque substances used in oral cholecystography].
[Ti] Título:Estudio clínico-radiológico de tres radiopacos empleados en la colecistografía oral..
[So] Source:Rev Med Chil;110(8):761-5, 1982 Aug.
[Is] ISSN:0034-9887
[Cp] País de publicação:Chile
[La] Idioma:spa
[Mh] Termos MeSH primário: Colecistografia
Meios de Contraste
Iodobenzenos
Ácido Iopanoico
Tiropanoato
[Mh] Termos MeSH secundário: Ácido Acetrizoico/administração & dosagem
Administração Oral
Adulto
Doenças Biliares/diagnóstico por imagem
Meios de Contraste/administração & dosagem
Feminino
Seres Humanos
Ácido Iopanoico/administração & dosagem
Masculino
Meia-Idade
Tiropanoato/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Iodobenzenes); 24256BQV7M (Acetrizoic Acid); 4F05V145YR (Tyropanoate); FE9794P71J (Iopanoic Acid)
[Em] Mês de entrada:8303
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:820801
[St] Status:MEDLINE


  7 / 27 MEDLINE  
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Fotocópia
[PMID]:7141832
[Au] Autor:Muhletaler CA; Gerlock AJ; Amberg JR; Avant GR
[Ti] Título:Radiographic appearance of the nonabsorbed (unconjugated) and conjugated sodium tyropanoate (Bilopaque) in the bowel.
[So] Source:Invest Radiol;17(5):506-9, 1982 Sep-Oct.
[Is] ISSN:0020-9996
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A series of abdominal radiographs were taken in eight normal volunteers after the ingestion of sodium tyropanoate (Bilopaque). These showed nonabsorbed sodium tyropanoate to have a granular appearance, while the conjugated form had a smooth homogeneous appearance. The appearance of conjugated sodium tyropanoate in the bowel has the same diagnostic significance as conjugated iopanoic acid in the presence of a nonvisualized gallbladder. It indicates that the contrast material has passed through the hepatic ductal system and that there has been an opportunity for the gallbladder to opacify.
[Mh] Termos MeSH primário: Colecistografia
Iodobenzenos/metabolismo
Tiropanoato/metabolismo
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Absorção Intestinal
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodobenzenes); 4F05V145YR (Tyropanoate)
[Em] Mês de entrada:8301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:820901
[St] Status:MEDLINE


  8 / 27 MEDLINE  
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Fotocópia
PubMed Central Texto completo
[PMID]:7092818
[Au] Autor:Fekkes D; Hennemann G; Visser TJ
[Ti] Título:Evidence for a single enzyme in rat liver catalysing the deiodination of the tyrosyl and the phenolic ring of iodothyronines.
[So] Source:Biochem J;201(3):673-6, 1982 Mar 01.
[Is] ISSN:0264-6021
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The enzymic 5'-deiodination of 3',5'-di-iodothyronine and 5-deiodination of 3,3',5-tri-iodothyronine by rat liver microsomal fractions were found to be characterized by apparent Km values of 0.77 and 17.4 microM respectively, 3',5'-Di-iodothyronine was a competitive inhibitor of 3,3',5-tri-iodothyronine 5-deiodination (Ki 0.65 microM) and 3,3',5-tri-iodothyronine was a competitive inhibitor of 3',5'-di-iodothyronine 5'-deiodination (Ki 19.6 microM). In addition, several radiographic contrast agents and iodothyronine analogues inhibited both reactions competitively and with equal potencies (r = 0.999). These results strongly suggest the existence of a single hepatic deiodinase acting on both the tyrosyl and phenolic ring of iodothyronines.
[Mh] Termos MeSH primário: Di-Iodotironinas/metabolismo
Microssomos Hepáticos/enzimologia
Tironinas/metabolismo
Tri-Iodotironina/metabolismo
[Mh] Termos MeSH secundário: Animais
Meios de Contraste/farmacologia
Técnicas In Vitro
Iodo/metabolismo
Cinética
Microssomos Hepáticos/efeitos dos fármacos
Ratos
Tiropanoato/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 0 (Diiodothyronines); 0 (Thyronines); 06LU7C9H1V (Triiodothyronine); 4F05V145YR (Tyropanoate); 60363-25-9 (3',5'-diiodothyronine); 9679TC07X4 (Iodine)
[Em] Mês de entrada:8208
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:820301
[St] Status:MEDLINE


  9 / 27 MEDLINE  
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Fotocópia
[PMID]:7089280
[Au] Autor:Fon GT; Hunter TB; Berk RN; Patton DD; Capp MP
[Ti] Título:Subjective vs. objective evaluation of gallbladder opacification during oral cholecystography in comparative clinical trials: implications for studies involving visual assessment.
[So] Source:Radiology;144(2):277-80, 1982 Jul.
[Is] ISSN:0033-8419
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Radiographs and CT images taken during oral cholecystography in dogs were interpreted in an independent, blind fashion by three radiologists on two occasions and visual assessment of gallbladder density compared to the actual CT values. While there was significant intra- and inter-observer variation, the mean scores for the observers' interpretations of both radiographs and prints correlated well with the actual CT values (p less than 0.05). In five out of six comparisons between first and second readings, the observers gave a lower score on the second reading. The considerable variation reflects the problems inherent in subjective evaluation of agents that produce small but measurable differences in radiographic density. Studies involving such subjective data have to be carefully designed in order to obtain meaningful results.
[Mh] Termos MeSH primário: Colecistografia
Meios de Contraste/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Animais
Tomada de Decisões
Cães
Avaliação Pré-Clínica de Medicamentos
Ácido Iopanoico/administração & dosagem
Ipodato/administração & dosagem
Distribuição Aleatória
Tomografia Computadorizada por Raios X
Tiropanoato/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Contrast Media); 4F05V145YR (Tyropanoate); F604ZKI910 (Ipodate); FE9794P71J (Iopanoic Acid)
[Em] Mês de entrada:8208
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:820701
[St] Status:MEDLINE


  10 / 27 MEDLINE  
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Fotocópia
[PMID]:7045975
[Au] Autor:Thoeni RF; Moss AA
[Ti] Título:A clinical trial of oral cholecystography using combinations of contrast agents and two consecutive doses.
[So] Source:Radiology;144(2):271-5, 1982 Jul.
[Is] ISSN:0033-8419
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fifteen healthy volunteers underwent a randomized trial of oral cholecystography (OCG) using 5 different combinations of contrast agents given as 2 consecutive doses: Telepaque (iopanoic acid) given with food (TF) or without food (T), Bilopaque (sodium tyropanoate) given without food, and a combination of both agents (TF-B). The density of gallbladder opacification was judged visually on a scale of 1+ to 4+ and quantitatively by a densitometric method. Comparison of gallbladder opacification on the first and second days of the study revealed 52 of 75 (70%) combinations (TF-T, TF-TF,T-T, TF-B, B-B) resulted in improved opacification, 17% in equal opacification, and 13% in worse opacification on day 2. The TF-B combination showed the highest number (9) of excellent (grade 4+) results and the lowest number (2) of poor (grade 1+ and 2+) results, gave the best opacification in 8 volunteers, and had the highest average density difference (0.32) between first- and second-day opacifications. The TF-TF combination was the next most effective, and the T-T combination was the least effective. The results indicate that OCG in 2 consecutive doses is superior to single-dose OCG, and that a combination of TF-B or TF-TF will provide the greatest gallbladder opacification. The TF-B combination is recommended because of better patient tolerance.
[Mh] Termos MeSH primário: Colecistografia/métodos
Meios de Contraste/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Ensaios Clínicos como Assunto
Esquema de Medicação
Jejum
Feminino
Alimentos
Seres Humanos
Ácido Iopanoico/administração & dosagem
Masculino
Meia-Idade
Distribuição Aleatória
Tiropanoato/administração & dosagem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Contrast Media); 4F05V145YR (Tyropanoate); FE9794P71J (Iopanoic Acid)
[Em] Mês de entrada:8208
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:820701
[St] Status:MEDLINE



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