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  1 / 1347 MEDLINE  
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[PMID]:28957373
[Au] Autor:Araújo DFS; Guerra GCB; Pintado MME; Sousa YRF; Algieri F; Rodriguez-Nogales A; Araújo RF; Gálvez J; Queiroga RCRE; Rodriguez-Cabezas ME
[Ad] Endereço:Faculty of Health Sciences of Trairi, Federal University of Rio Grande do Norte, Santa Cruz, Brazil.
[Ti] Título:Intestinal anti-inflammatory effects of goat whey on DNBS-induced colitis in mice.
[So] Source:PLoS One;12(9):e0185382, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study evaluated the intestinal anti-inflammatory effects of goat whey in a mouse model of colitis induced by 2,4-dinitrobenzenesulfonic acid that resembles human IBD. At a concentration of 4 g/kg/day, the goat whey improved the symptoms of intestinal inflammation, namely by decreasing the disease activity index, colonic weight/length, and leukocyte infiltration. Moreover, goat whey inhibited NF-κB p65 and p38 MAPK signaling pathways and consequently down-regulated the gene expression of various proinflammatory markers such as IL-1ß, IL-6, IL-17, TNF-α, iNOS, MMP-9, ICAM-1. Also, goat whey increased the expression of proteins such as mucins, occludin proteins and cytokine signalling suppressors. The immunomodulatory properties of goat whey were also evaluated in vitro using the murine macrophage cell line Raw 264 and CMT-93 cells derived from mouse rectum carcinomas. The results revealed the ability of goat whey to inhibit the production of NO and reduce IL-6 production in LPS-stimulated cells. In conclusion, goat whey exhibited anti-inflammatory effects in the DNBS model of intestinal inflammation, and these observations were confirmed by its immunomodulatory properties in vitro. Together, our results indicate that goat whey could have applications for the treatment of IBD.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Colite/induzido quimicamente
Colite/patologia
Intestinos/patologia
Soro do Leite/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Colite/genética
Citocinas/genética
Citocinas/metabolismo
Dinitrofluorbenzeno/análogos & derivados
Modelos Animais de Doenças
Ensaio de Imunoadsorção Enzimática
Imunofluorescência
Regulação da Expressão Gênica/efeitos dos fármacos
Cabras
Mediadores da Inflamação/metabolismo
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/patologia
Intestinos/efeitos dos fármacos
Masculino
Camundongos
Células RAW 264.7
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Inflammation Mediators); 143134-35-4 (2,4-dinitrofluorobenzene sulfonic acid); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185382


  2 / 1347 MEDLINE  
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[PMID]:28687491
[Au] Autor:Hirunwidchayarat W; Furusawa E; Kang S; Ohno T; Takeuchi S; Rungsiyanont S; Azuma M
[Ad] Endereço:Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan; Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirote University, 114 Sukhumvit 23, Wattana District, Bang
[Ti] Título:Site-specific regulation of oral mucosa-recruiting CD8 T cells in a mouse contact allergy model.
[So] Source:Biochem Biophys Res Commun;490(4):1294-1300, 2017 Sep 02.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contact allergy is a T cell-mediated, delayed-type hypersensitivity generated by contact exposure of an allergen to the skin and mucosal surface. The clinical manifestations of allergic responses between the skin and oral mucosa vary and the differences in immunopathology have not been clarified. We generated hapten-induced contact hypersensitivity (CH) of the buccal mucosa (BM) in parallel studies with ear skin (ES) CH, and observed several characteristic findings of BM CH. The BM challenge induced more rapid and more severe inflammation than the ES challenge, with abundant granulocyte and CD8 T cell infiltration. However, these inflammatory responses diminished quickly. Recruiting CD8 T cells in the BM had higher ratios of CD62L CD44 memory-type cells, and showed impaired IFN-γ, greater PD-1, and comparable Ki-67 expression, suggesting that the recruiting-proliferating CD8 T cells were unable to differentiate into effector T cells and converted into exhausted T cells at the local site. This finding may explain the rapid recovery of the BM from severe inflammation. Preferentially greater expression of PD-1 ligand (B7-H1), was observed in the BM epithelium under the peak inflammation, and the absence of B7-H1 further accelerated CH responses, suggesting the occurrence of PD-1:B7-H1-mediated immune regulation at the local site. Our results may facilitate the understanding of the unique features of contact allergies in the oral mucosa, and guide the development of new strategies for control of contact allergy.
[Mh] Termos MeSH primário: Linfócitos T CD8-Positivos/imunologia
Dermatite de Contato/imunologia
Granulócitos/imunologia
Mucosa Bucal/imunologia
Pele/imunologia
[Mh] Termos MeSH secundário: Animais
Antígeno B7-H1/genética
Antígeno B7-H1/imunologia
Linfócitos T CD8-Positivos/efeitos dos fármacos
Linfócitos T CD8-Positivos/patologia
Dermatite de Contato/etiologia
Dermatite de Contato/genética
Dermatite de Contato/patologia
Dinitrofluorbenzeno/toxicidade
Orelha
Feminino
Regulação da Expressão Gênica
Granulócitos/efeitos dos fármacos
Granulócitos/patologia
Receptores de Hialuronatos/genética
Receptores de Hialuronatos/imunologia
Memória Imunológica
Imunofenotipagem
Interferon gama/genética
Interferon gama/imunologia
Antígeno Ki-67/genética
Antígeno Ki-67/imunologia
Selectina L/genética
Selectina L/imunologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Mucosa Bucal/efeitos dos fármacos
Mucosa Bucal/patologia
Especificidade de Órgãos
Receptor de Morte Celular Programada 1/genética
Receptor de Morte Celular Programada 1/imunologia
Transdução de Sinais
Pele/efeitos dos fármacos
Pele/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-H1 Antigen); 0 (CD274 protein, human); 0 (Cd44 protein, mouse); 0 (Hyaluronan Receptors); 0 (Ki-67 Antigen); 0 (Mki67 protein, mouse); 0 (PDCD1 protein, human); 0 (Programmed Cell Death 1 Receptor); 126880-86-2 (L-Selectin); 82115-62-6 (Interferon-gamma); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170709
[St] Status:MEDLINE


  3 / 1347 MEDLINE  
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[PMID]:28520986
[Au] Autor:Maruyama H; Oikawa R; Hayakawa M; Takamori S; Kimura Y; Abe N; Tsuji G; Matsuda A; Shuto S; Ito Y; Abe H
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
[Ti] Título:Chemical ligation of oligonucleotides using an electrophilic phosphorothioester.
[So] Source:Nucleic Acids Res;45(12):7042-7048, 2017 Jul 07.
[Is] ISSN:1362-4962
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We developed a new approach for chemical ligation of oligonucleotides using the electrophilic phosphorothioester (EPT) group. A nucleophilic phosphorothioate group on oligonucleotides was converted into the EPT group by treatment with Sanger's reagent (1-fluoro-2,4-dinitrobenzene). EPT oligonucleotides can be isolated, stored frozen, and used for the ligation reaction. The reaction of the EPT oligonucleotide and an amino-modified oligonucleotide took place without any extra reagents at pH 7.0-8.0 at room temperature, and resulted in a ligation product with a phosphoramidate bond with a 39-85% yield. This method has potential uses in biotechnology and chemical biology.
[Mh] Termos MeSH primário: Técnicas de Química Sintética
Dinitrofluorbenzeno/química
Oligonucleotídeos Fosforotioatos/síntese química
[Mh] Termos MeSH secundário: Sequência de Bases
Concentração de Íons de Hidrogênio
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphorothioate Oligonucleotides); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1093/nar/gkx459


  4 / 1347 MEDLINE  
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[PMID]:28393198
[Au] Autor:Son HU; Lee S; Heo JC; Lee SH
[Ad] Endereço:Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, P.R. China.
[Ti] Título:The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis.
[So] Source:Int J Mol Med;39(5):1233-1241, 2017 May.
[Is] ISSN:1791-244X
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Artemisia capillaris, which belongs to the Asteraceae family and the genus Artemisia, has been reported to exert inhibitory effects on diabetes, cancer and inflammation. In this study, in order to enhance the bioactivity potential of the leaves of Artemisia by Ganoderma lucidum mycelium, we prepared aqueous samples of Artemisia capillaris (Ac) leaves, Ganoderma lucidum (Gl) and aqueous fractions produced by the solid fermentation of Ganoderma lucidum on Artemisia capillaris leaves (afAc/Gl). Thereafter, we evaluated whether these samples have potential to attenuate inflammation-related symptoms in an amimal model of 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis. We found that afAc/Gl exhibited enhanced anti-inflamamatory activity following the solid fermentation process when compared with Ac or Gl on ear thickness, ear epidermal thickness and eosinophil infiltration in the skin tissues. The expression of nitric oxide (NO) synthases (NOSs) was measured by immunohistochemical staining. The results revealed that afAc/Gl decreased endothelial NOS and inducible NOS expression compared with the DNFB group, while neuronal NOS expression was not altered. By comparing NO production, we found that as opposed to Ac, afAc/Gl has potential to inhibit atopic dermatitis-related symptoms during the inflammatory event. As regards matrix metalloproteinase (MMP) expression patterns, afAc/Gl exerted potent inhibitory activity on the mRNA expression of MMP-2, -7, -9, -12, -14 and -19. Taken together, these results suggest that the solid state fermentation of Ac by Gl is an effective strategy to obtaining useful ingredients which are converted into valuable compounds during an atopic inflammatory insult.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Artemisia
Basidiomycota/metabolismo
Produtos Biológicos/farmacologia
Dermatite Atópica/patologia
Fermentação
Folhas de Planta
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Produtos Biológicos/química
Biópsia
Linhagem Celular
Dermatite Atópica/tratamento farmacológico
Dermatite Atópica/etiologia
Dermatite Atópica/metabolismo
Dinitrofluorbenzeno/efeitos adversos
Modelos Animais de Doenças
Masculino
Metaloproteinases da Matriz/metabolismo
Camundongos
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo III/genética
Óxido Nítrico Sintase Tipo III/metabolismo
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Biological Products); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); D241E059U6 (Dinitrofluorobenzene); EC 1.14.13.39 (Nitric Oxide Synthase Type III); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170411
[St] Status:MEDLINE
[do] DOI:10.3892/ijmm.2017.2945


  5 / 1347 MEDLINE  
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[PMID]:28214870
[Au] Autor:Haruna T; Soga M; Morioka Y; Imura K; Furue Y; Yamamoto M; Hayakawa J; Deguchi M; Arimura A; Yasui K
[Ad] Endereço:Drug Discovery and Disease Research Laboratory,SHIONOGI & Co., Ltd., Osaka, Japan.
[Ti] Título:The Inhibitory Effect of S-777469, a Cannabinoid Type 2 Receptor Agonist, on Skin Inflammation in Mice.
[So] Source:Pharmacology;99(5-6):259-267, 2017.
[Is] ISSN:1423-0313
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:We investigated the effects of S-777469 (1-[[6-Ethyl-1-[4-fluorobenzyl]-5-methyl-2-oxo-1, 2-dihydropyridine-3-carbonyl]amino]-cyclohexanecarboxylic acid), a novel cannabinoid type 2 receptor (CB2) agonist, on 1-fluoro-2,4-dinitrobenzene (DNFB)-induced ear inflammation and mite antigen-induced dermatitis in mice. The oral administration of S-777469 significantly suppressed DNFB-induced ear swelling in a dose-dependent manner. In addition, S-777469 significantly alleviated mite antigen-induced atopic dermatitis-like skin lesions in NC/Nga mice. A histological analysis revealed that S-777469 significantly reduced the epidermal thickness and the number of mast cells infiltrating skin lesions. We demonstrated that S-777469 inhibited mite antigen-induced eosinophil accumulation in skin lesions and an endogenous CB2 ligand, 2-arachidonoylglycerol (2-AG)-induced eosinophil migration in vitro. Moreover, we confirmed that 2-AG levels significantly increased in skin lesions of mite antigen-induced dermatitis model. Together, these results suggest that S-777469 inhibits skin inflammation in mice by blocking the activities of 2-AG.
[Mh] Termos MeSH primário: Inflamação/tratamento farmacológico
Piridonas/farmacologia
Piridonas/uso terapêutico
Receptor CB2 de Canabinoide/agonistas
Pele/efeitos dos fármacos
Pele/patologia
[Mh] Termos MeSH secundário: Animais
Ácidos Araquidônicos/antagonistas & inibidores
Ácidos Araquidônicos/metabolismo
Ensaios de Migração de Leucócitos
Dermatite Atópica/tratamento farmacológico
Dermatite Atópica/metabolismo
Dinitrofluorbenzeno
Relação Dose-Resposta a Droga
Endocanabinoides/antagonistas & inibidores
Endocanabinoides/metabolismo
Glicerídeos/antagonistas & inibidores
Glicerídeos/metabolismo
Inflamação/induzido quimicamente
Masculino
Camundongos
Infestações por Ácaros/tratamento farmacológico
Infestações por Ácaros/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arachidonic Acids); 0 (Cnr2 protein, mouse); 0 (Endocannabinoids); 0 (Glycerides); 0 (Pyridones); 0 (Receptor, Cannabinoid, CB2); 0 (S-777469); 8D239QDW64 (glyceryl 2-arachidonate); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170220
[St] Status:MEDLINE
[do] DOI:10.1159/000455916


  6 / 1347 MEDLINE  
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[PMID]:28143472
[Au] Autor:El Azhary K; Tahiri Jouti N; El Khachibi M; Moutia M; Tabyaoui I; El Hou A; Achtak H; Nadifi S; Habti N; Badou A
[Ad] Endereço:Environnement and Health team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Safi, Morocco.
[Ti] Título:Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.
[So] Source:BMC Complement Altern Med;17(1):81, 2017 Jan 31.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several chronic inflammatory diseases are characterized by inappropriate CD4+ T cell response. In the present study, we assessed the ability of Capparis spinosa L. (CS) preparation to orientate, in vivo, the immune response mediated by CD4+ T cells towards an anti-inflammatory response. METHODS: The in vivo study was carried out by using the contact hypersensitivity (CHS) model in Swiss mice. Then we performed a histological analysis followed by molecular study by using real time RT-PCR. We also realized a phytochemical screening and a liquid-liquid separation of CS preparation. RESULTS: Our study allowed us to detect a significantly reduced edema in mice treated with CS preparations relative to control. CS effect was dose dependent, statistically similar to that observed with indomethacin, independent of the plant genotype and of the period of treatment. Furthermore, our histology studies revealed that CS induced a significant decrease in immune cell infiltration, in vasodilatation and in dermis thickness in the inflammatory site. Interestingly, we showed that CS operated by inhibiting cytokine gene expression including IFNγ, IL-17 and IL-4. Besides, phytochemical screening of CS extract showed the presence of several chemical families such as saponins, flavonoids and alkaloids. One (hexane fraction) out of the three distinct prepared fractions, exhibited an anti-inflammatory effect similar to that of the raw preparation, and would likely contain the bioactive(s) molecule(s). CONCLUSIONS: Altogether, our data indicate that CS regulates inflammation induced in vivo in mice and thus could be a source of anti-inflammatory molecules, which could be used in some T lymphocyte-dependent inflammatory diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Capparis/química
Citocinas/genética
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetatos
Animais
Anti-Inflamatórios não Esteroides/isolamento & purificação
Capparis/genética
Dermatite de Contato/tratamento farmacológico
Dermatite de Contato/etiologia
Dinitrofluorbenzeno
Feminino
Expressão Gênica/efeitos dos fármacos
Genótipo
Hexanos
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Inflamação/patologia
Metanol
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Hexanes); 0 (Plant Extracts); 76845O8NMZ (ethyl acetate); D241E059U6 (Dinitrofluorobenzene); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1569-7


  7 / 1347 MEDLINE  
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[PMID]:27748951
[Au] Autor:Manabe Y; Yoshimura M; Sakamaki K; Inoue A; Kakinoki A; Hokari S; Sakanaka M; Aoki J; Miyachi H; Furuta K; Tanaka S
[Ad] Endereço:Department of Immunobiology, Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
[Ti] Título:1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells.
[So] Source:Eur J Immunol;47(1):60-67, 2017 Jan.
[Is] ISSN:1521-4141
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Accumulating evidence suggests that activated mast cells are involved in contact hypersensitivity, although the precise mechanisms of their activation are still not completely understood. We investigated the potential of common experimental allergens to induce mast cell activation using murine bone marrow-derived cultured mast cells and rat peritoneal mast cells. Among these allergens, 1-chloro-2,4-dinitrobenzene and 1-fluoro-2,4-dinirobenzene (DNFB) were found to induce degranulation of rat peritoneal mast cells. DNFB-induced degranulation is accompanied by cytosolic Ca mobilization and is significantly inhibited by pertussis toxin, U73122 (a phospholipase C inhibitor), and BAPTA (a Ca chelator), raising the possibility that DNFB acts on the G protein-coupled receptors and activates G , which induces activation of phospholipase C, as well as known mast cell secretagogues, such as compound 48/80. DNFB could induce mast cell degranulation in the absence of serum proteins and IgE. Structure-activity relationship analyses revealed an inverse correlation between the degree of degranulation and the electron density of the C1 carbon of the DNFB derivatives. These findings raise a possibility that DNFB functions as a potent contact allergen through induction of cutaneous mast cell degranulation.
[Mh] Termos MeSH primário: Alérgenos/imunologia
Degranulação Celular/imunologia
Dinitrofluorbenzeno/imunologia
Mastócitos/imunologia
Mastócitos/secreção
[Mh] Termos MeSH secundário: Alérgenos/química
Animais
Cálcio/metabolismo
Citocinas/metabolismo
Dinitrofluorbenzeno/análogos & derivados
Dinitrofluorbenzeno/química
Proteínas de Ligação ao GTP/química
Proteínas de Ligação ao GTP/metabolismo
Masculino
Camundongos
Estrutura Molecular
Ligação Proteica
Multimerização Proteica
Ratos
Transdução de Sinais
Fosfolipases Tipo C/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Cytokines); D241E059U6 (Dinitrofluorobenzene); EC 3.1.4.- (Type C Phospholipases); EC 3.6.1.- (GTP-Binding Proteins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE
[do] DOI:10.1002/eji.201646536


  8 / 1347 MEDLINE  
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[PMID]:27725451
[Au] Autor:Nishimura K; Aoyanagi N; Uchino E; Itabashi Y
[Ad] Endereço:Hokkaido Institute of Public Health.
[Ti] Título:Influence of Hot Spring Water on Fatty Acid Composition of Skin Surface Lipids in Hairless Mouse Model of Atopic Dermatitis.
[So] Source:Biol Pharm Bull;39(10):1718-1722, 2016.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:When hairless NCN24 mice with atopic dermatitis (AD) were sprayed with a petroleum-containing alkaline salt spring water rich in metaboric acid and sodium bicarbonate, AD symptoms diminished. Reversed-phase HPLC with fluorescence detection (HPLC/FD) and online MS revealed that fatty acid (FA) composition of the skin surface lipids was similar to that in non-AD mice compared with that in AD mice. Strong negative correlations were noted between the levels of total serum immunoglobulin E (IgE) and palmitoleic acid and between the levels of total serum IgE and branched-hexadecanoic acid. Conversely, a strong positive correlation was noted between the levels of total serum IgE and linoleic acid. The present study demonstrates that the petroleum-containing spring water alters the FA composition of skin surface lipids in AD mice, which can be used as an index to evaluate inflammation.
[Mh] Termos MeSH primário: Dermatite Atópica/metabolismo
Ácidos Graxos/metabolismo
Fontes Termais
Petróleo
Pele/metabolismo
[Mh] Termos MeSH secundário: Animais
Dermatite Atópica/sangue
Dermatite Atópica/induzido quimicamente
Dinitrofluorbenzeno
Modelos Animais de Doenças
Imunoglobulina E/sangue
Metabolismo dos Lipídeos/efeitos dos fármacos
Masculino
Camundongos Pelados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Petroleum); 37341-29-0 (Immunoglobulin E); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170127
[Lr] Data última revisão:
170127
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


  9 / 1347 MEDLINE  
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[PMID]:27720681
[Au] Autor:Vaia M; Petrosino S; De Filippis D; Negro L; Guarino A; Carnuccio R; Di Marzo V; Iuvone T
[Ad] Endereço:Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
[Ti] Título:Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.
[So] Source:Eur J Pharmacol;791:669-674, 2016 Nov 15.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In mice, 2,4-dinitrofluorobenzene (DNFB) induces contact allergic dermatitis (CAD), which, in a late phase, is characterized by mast cell (MC) infiltration and angiogenesis. Palmitoylethanolamide (PEA), an endogenous anti-inflammatory molecule, acts by down-modulating MCs following activation of the cannabinoid CB receptor and peroxisome proliferator-activated receptor-α (PPAR-α). We have previously reported the anti-inflammatory effect of PEA in the early stage of CAD. Here, we examined whether PEA reduces the features of the late stage of CAD including MC activation, angiogenesis and itching. After sensitization to DNFB, female C57BL/6J mice underwent to three DNFB challenges at days 5, 12 and 19 and treatments were given at each challenge and for two more days. CAD was expressed as Δ increase in ear thickness between challenged and un-challenged mice. PEA (5mg/kg/i.p.) reduced: i) the DNFB-induced Δ increase; ii) the number of MCs per tissue area; iii) the expression of VEGF and its receptor Flk-1. These effects were reversed by co-administration of AM630 (1mg/kg/i.p.), a CB antagonist, but not GW6471 (1mg/kg/i.p.), a PPAR-α antagonist. Finally, PEA reduced the number of ear scratchings 48h after DNFB challenge and this effect was reversed by both CB2 and PPAR-α antagonists, suggesting the involvement of both receptors. PEA, by reducing the features of late stage CAD in mice, may be beneficial in this pathological condition.
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/complicações
Dermatite Alérgica de Contato/tratamento farmacológico
Etanolaminas/farmacologia
Ácidos Palmíticos/farmacologia
Prurido/complicações
[Mh] Termos MeSH secundário: Animais
Contagem de Células
Dermatite Alérgica de Contato/imunologia
Dermatite Alérgica de Contato/metabolismo
Dinitrofluorbenzeno/efeitos adversos
Modelos Animais de Doenças
Endocanabinoides/metabolismo
Etanolaminas/uso terapêutico
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Inflamação/complicações
Mastócitos/citologia
Mastócitos/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos C57BL
Ácidos Palmíticos/uso terapêutico
Fator A de Crescimento do Endotélio Vascular/metabolismo
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocannabinoids); 0 (Ethanolamines); 0 (Palmitic Acids); 0 (Vascular Endothelial Growth Factor A); 6R8T1UDM3V (palmidrol); D241E059U6 (Dinitrofluorobenzene); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27692854
[Au] Autor:Abeywardane A; Caviness G; Choi Y; Cogan D; Gao A; Goldberg D; Heim-Riether A; Jeanfavre D; Klein E; Kowalski JA; Mao W; Miller C; Moss N; Ramsden P; Raymond E; Skow D; Smith-Keenan L; Snow RJ; Wu F; Wu JP; Yu Y
[Ad] Endereço:Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA.
[Ti] Título:N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity.
[So] Source:Bioorg Med Chem Lett;26(21):5277-5283, 2016 11 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Compound 1 ((4-amino-3,5-dichlorophenyl)-1-(4-methylpiperidin-1-yl)-4-(2-nitroimidazol-1-yl)-1-oxobutane-2-sulfonamido) was discovered to be a 690nM antagonist of human CCR10 Ca flux. Optimization delivered (2R)-4-(2-cyanopyrrol-1-yl)-S-(1H-indol-4-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutane-2-sulfonamido (eut-22) that is 300 fold more potent a CCR10 antagonist than 1 and eliminates potential toxicity, mutagenicity, and drug-drug-interaction liabilities often associated with nitroaryls and anilines. eut-22 is highly selective over other GPCR's, including a number of other chemokine receptors. Finally, eut-22 is efficacious in the murine DNFB model of contact hypersensitivity. The efficacy of this compound provides further evidence for the role of CCR10 in dermatological inflammatory conditions.
[Mh] Termos MeSH primário: Amidas/farmacologia
Dermatite de Contato/tratamento farmacológico
Dinitrofluorbenzeno/toxicidade
Modelos Animais de Doenças
Receptores CCR10/antagonistas & inibidores
[Mh] Termos MeSH secundário: Amidas/química
Amidas/uso terapêutico
Animais
Ácidos Carboxílicos/química
Linhagem Celular
Seres Humanos
Camundongos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Carboxylic Acids); 0 (Ccr10 protein, mouse); 0 (Receptors, CCR10); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE



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