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[PMID]:29353721
[Au] Autor:Purushothaman B; Arumugam P; Kulsi G; Song JM
[Ad] Endereço:College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
[Ti] Título:Design, synthesis, and biological evaluation of novel catecholopyrimidine based PDE4 inhibitor for the treatment of atopic dermatitis.
[So] Source:Eur J Med Chem;145:673-690, 2018 Feb 10.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Selective inhibition of phosphodiesterase (PDE) 4B favorably suppresses the synthesis of inflammatory cytokines and subsequently arrest the development of atopic dermatitis via modulating the intracellular cAMP levels. Considering the side effects of corticosteroids, selective PDE4 inhibition could constitute an effective alternative therapy for the treatment of atopic dermatitis (AD). In this study, a series of novel catechol based compounds bearing pyrimidine as the core have been synthesized and screened for the PDE4 inhibitory properties. The PDE4 selectivity of the active compounds over other PDEs has been investigated. Compound 23 bearing pyrimidine core functionalized with catechol, pyridine and trifluoromethyl groups can effectively inhibit the PDE4B with IC value in nanomolar range (IC = 15 ±â€¯0.4 nM). Compound 23 exhibited seven fold higher selectivity towards PDE4B over PDE4D. Molecular Docking study confirmed its stronger affinity towards catalytic domain of PDE4B. In-vivo analysis confirmed that compound 23 effectively alleviated the symptoms of atopic dermatitis in DNCB-treated Balb/c mice by suppressing the synthesis of inflammatory mediators such as TNF-α, and Ig-E. Taken together, this study suggested that compound 23 could be an effective PDE4 inhibitor for the potential treatment of AD.
[Mh] Termos MeSH primário: Catecóis/farmacologia
Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo
Dermatite Atópica/tratamento farmacológico
Desenho de Drogas
Inibidores da Fosfodiesterase 4/farmacologia
Pirimidinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Catecóis/síntese química
Catecóis/química
Cristalografia por Raios X
Dermatite Atópica/metabolismo
Dermatite Atópica/patologia
Relação Dose-Resposta a Droga
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Modelos Moleculares
Estrutura Molecular
Inibidores da Fosfodiesterase 4/síntese química
Inibidores da Fosfodiesterase 4/química
Pirimidinas/síntese química
Pirimidinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Phosphodiesterase 4 Inhibitors); 0 (Pyrimidines); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


  2 / 6242 MEDLINE  
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[PMID]:29205772
[Au] Autor:Taher ES; Banwell MG; Buckler JN; Yan Q; Lan P
[Ad] Endereço:Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 2601, Australia.
[Ti] Título:The Exploitation of Enzymatically-Derived cis-1,2-Dihydrocatechols and Related Compounds in the Synthesis of Biologically Active Natural Products.
[So] Source:Chem Rec;18(2):239-264, 2018 Feb.
[Is] ISSN:1528-0691
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The title compounds of the general form 1 can be produced at large scale and in essentially enantiomerically pure form (when X≠H) through the whole cell biotransformation of the corresponding aromatic. The "dense" and varied functionality associated with these metabolites mean that they have become increasingly useful chirons for the total synthesis of a range of natural product types. This personal account details the outcomes of a nearly three-decade long campaign within our group to exploit these compounds in the synthesis of a diverse range of small molecule natural product targets. The work is subdivided according to the key transformation(s) employed in each synthesis. The development of newer chirons that "complement" the utility of the cis-1,2-dihydrocatechols are also described.
[Mh] Termos MeSH primário: Produtos Biológicos/metabolismo
Catecóis/metabolismo
Oxirredutases/metabolismo
Oxigenases/metabolismo
[Mh] Termos MeSH secundário: Produtos Biológicos/química
Catecóis/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Biological Products); 0 (Catechols); 0 (cis-1,2-dihydrocatechol); EC 1.- (Oxidoreductases); EC 1.13.- (Oxygenases); EC 1.14.12.11 (toluene dioxygenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/tcr.201700064


  3 / 6242 MEDLINE  
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[PMID]:28744886
[Au] Autor:Zhao A; Zhang L; Li R; Shang J; Yi H; Wang Y; Zhang D; Wang S; Fang M
[Ad] Endereço:Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, China.
[Ti] Título:Development and validation of an LC-MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription.
[So] Source:Biomed Chromatogr;32(2), 2018 Feb.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A sensitive, specific and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous determination of seven constituents of the Zaoren Anshen prescription (ZAP) in rat plasma after oral administration of the ZAP: spinosin, salvianic acid A, 6'''-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin. The plasma samples and the internal standard (IS) sulfamethoxazole were extracted using acetonitrile. Chromatographic separation was performed with an Agilent HC-C column using a gradient elution profile and a mobile phase consisting of 0.01% formic acid in water (A) and acetonitrile (B). The analytes were quantified simultaneously in a single run using an ion trap mass spectrometer operated in the multiple reaction monitoring mode and electrospray ion-source polarity in the positive and negative modes. The calibration curves for spinosin, salvianic acid A, 6'''-feruloylspinosin, protocatechualdehyde, salvianolic acid B, schisandrin and deoxyschisandrin were linear over the concentration ranges of 2.90-1160, 2.50-1000, 1.80-720, 0.65-260, 2.50-1000, 8.00-1600 and 1.30-520 ng/mL, respectively. The intra- and inter-day precisions in terms of relative standard deviation were <18.9%, and the accuracies in terms of relative error were within ±14.2%. Consequently, the proposed method was successfully applied to the pharmacokinetic analysis of these seven major active compounds in rats administered ZAP. These results will facilitate research aiming to predict the effectiveness of the optimal dose of ZAP and might be beneficial for the therapeutic use of ZAP in the clinical setting.
[Mh] Termos MeSH primário: Benzaldeídos/sangue
Benzofuranos/sangue
Catecóis/sangue
Ciclo-Octanos/sangue
Medicamentos de Ervas Chinesas/farmacocinética
Flavonoides/sangue
Lignanas/sangue
Compostos Policíclicos/sangue
[Mh] Termos MeSH secundário: Animais
Benzaldeídos/química
Benzaldeídos/farmacocinética
Benzofuranos/química
Benzofuranos/farmacocinética
Catecóis/química
Catecóis/farmacocinética
Cromatografia Líquida/métodos
Ciclo-Octanos/química
Ciclo-Octanos/farmacocinética
Estabilidade de Medicamentos
Medicamentos de Ervas Chinesas/análise
Medicamentos de Ervas Chinesas/química
Flavonoides/química
Flavonoides/farmacocinética
Lignanas/química
Lignanas/farmacocinética
Limite de Detecção
Modelos Lineares
Masculino
Compostos Policíclicos/química
Compostos Policíclicos/farmacocinética
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzaldehydes); 0 (Benzofurans); 0 (Catechols); 0 (Cyclooctanes); 0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Lignans); 0 (Polycyclic Compounds); 4PVP2HCH4T (protocatechualdehyde); 72063-39-9 (spinosin); C1GQ844199 (salvianolic acid B); G01BQC0879 (schizandrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.4055


  4 / 6242 MEDLINE  
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[PMID]:28458348
[Au] Autor:Lee DI; Jang SK; Park DW; Kim ST; Park JS; Jo BR; Park JY; Park HY; Joo SS
[Ad] Endereço:College of Pharmacy, Chung-Ang University.
[Ti] Título:Diarylheptanoid Hirsutenone Attenuates Osteoclastogenesis by Suppressing IFNγ and NF-κB Signaling in Th1 and Preosteoclastic Cells.
[So] Source:Biol Pharm Bull;40(5):630-637, 2017.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to examine the inhibitory roles and mechanisms of hirsutenone (HTN) in the regulation of osteoclastogenesis. Gene levels were compared to assure the effects of HTN on osteoclastogenesis in mouse splenocytes/CD4 T cells, mouse macrophage-like cell line RAW264.7 (preosteoclast), MG63 (osteoblast), and RPMI1788 (B cell) cells. The mechanism by which HTN regulates the degradation of tumor necrosis factor receptor-associated factor 6 (TRAF6) and inhibits inhibitor of kappaB (IκB) and nuclear factor-kappaB (NF-κB) signaling was examined by Western blotting and luciferase reporter assays. Our results demonstrated that HTN effectively downregulated the expression of interferon γ (IFNγ), interleukin-22 (IL-22), IL-1ß, and tartrate-resistant acid phosphatase (TRAP) in splenocyte-/CD4 -RAW264.7 co-culture system. Moreover, receptor activator of nuclear factor-κB ligand (RANKL) and CD25 expression were also significantly inhibited in MG63 and CD4 single culture system, suggesting an additional independent effect of HTN on osteoclastogenesis. Notably, TRAF6 was markedly degraded along with a decrease in nuclear factor of activated T-cells (NFATc) and NF-κB activities in RAW264.7 cells. Finally, we concluded that HTN directly or indirectly inhibits osteoclastogenesis via the inhibition of NF-κB signaling by promoting TRAF6 degradation, and plays a crucial role in suppressing the expression of RANKL and cytokines expressed in IFNγ-producing T-helper 1 (Th1) cells. These findings suggest that HTN may be a promising therapeutic candidate for diseases resulting from bone loss.
[Mh] Termos MeSH primário: Catecóis/farmacologia
Diarileptanoides/farmacologia
Interferon gama/antagonistas & inibidores
NF-kappa B/antagonistas & inibidores
Osteoclastos/efeitos dos fármacos
Células Th1/efeitos dos fármacos
[Mh] Termos MeSH secundário: Alnus/química
Animais
Linfócitos T CD4-Positivos/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Citocinas/antagonistas & inibidores
Citocinas/farmacologia
Camundongos
Camundongos Endogâmicos BALB C
Osteogênese/efeitos dos fármacos
Casca de Planta/química
Ligante RANK/genética
Células RAW 264.7
Transdução de Sinais/efeitos dos fármacos
Baço/química
Baço/citologia
Células-Tronco/efeitos dos fármacos
Fosfatase Ácida Resistente a Tartarato/biossíntese
Fosfatase Ácida Resistente a Tartarato/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Cytokines); 0 (Diarylheptanoids); 0 (NF-kappa B); 0 (RANK Ligand); 0 (Tnfsf11 protein, mouse); 0 (hirsutenone); 82115-62-6 (Interferon-gamma); EC 3.1.3.2 (Acp5 protein, mouse); EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1248/bpb.b16-00876


  5 / 6242 MEDLINE  
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[PMID]:29364608
[Ti] Título:[Not Available.]
[So] Source:Mikrobiologiia;85(5):609-612, 2016 Sep.
[Is] ISSN:0026-3656
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Catecol 1,2-Dioxigenase/metabolismo
Catecóis/metabolismo
Hidroxibenzoatos/farmacologia
Rhodococcus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas de Bactérias/genética
Proteínas de Bactérias/isolamento & purificação
Catecol 1,2-Dioxigenase/genética
Catecol 1,2-Dioxigenase/isolamento & purificação
Catecóis/química
Ativação Enzimática/efeitos dos fármacos
Ensaios Enzimáticos
Expressão Gênica
Cinética
Rhodococcus/enzimologia
Rhodococcus/genética
Frações Subcelulares/química
Frações Subcelulares/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Catechols); 0 (Hydroxybenzoates); 2ZFW40OJ7U (3-hydroxybenzoic acid); EC 1.13.11.1 (Catechol 1,2-Dioxygenase)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE


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[PMID]:29025662
[Au] Autor:Li S; Wang L; Yu X; Wang C; Wang Z
[Ad] Endereço:Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, PR China.
[Ti] Título:Synthesis and characterization of a novel double cross-linked hydrogel based on Diels-Alder click reaction and coordination bonding.
[So] Source:Mater Sci Eng C Mater Biol Appl;82:299-309, 2018 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Hydrogels, promising biological materials, need to have both strong mechanical properties and also inherent self-healing properties. In this work a double cross-linked network (DN) hydrogel was designed and prepared by combining a Diels-Alder click reaction and coordination effects. This DN hydrogel had good thermodynamic properties, anti-EDTA performance and self-healing properties. In addition, the mechanical properties, swelling properties and surface morphology of DN hydrogels can be controlled by adjusting the ratio of Fe -catechol. The adjustment of pH value can change the color, crosslinking mode and mechanical properties of the DN hydrogel. This smart hydrogel created from DA click chemistry and coordination effects has significance for guiding the design of new hydrogels with good mechanical properties, self-healing properties and controlled cross-link density.
[Mh] Termos MeSH primário: Hidrogéis/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Catecóis/química
Quitosana/química
Química Click
Reação de Cicloadição
Compostos Férricos/química
Hidrogéis/síntese química
Concentração de Íons de Hidrogênio
Espectroscopia de Ressonância Magnética
Reologia
Espectrofotometria Ultravioleta
Espectroscopia de Infravermelho com Transformada de Fourier
Termogravimetria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Ferric Compounds); 0 (Hydrogels); 9012-76-4 (Chitosan); LF3AJ089DQ (catechol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  7 / 6242 MEDLINE  
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[PMID]:28460529
[Au] Autor:Winkler TE; Lederer SL; Kim E; Ben-Yoav H; Kelly DL; Payne GF; Ghodssi R
[Ad] Endereço:MEMS Sensors and Actuators Laboratory (MSAL), Institute for Systems Research, Department of Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742 and Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742.
[Ti] Título:Molecular processes in an electrochemical clozapine sensor.
[So] Source:Biointerphases;12(2):02B401, 2017 05 01.
[Is] ISSN:1559-4106
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Selectivity presents a crucial challenge in direct electrochemical sensing. One example is schizophrenia treatment monitoring of the redox-active antipsychotic clozapine. To accurately assess efficacy, differentiation from its metabolite norclozapine-similar in structure and redox potential-is critical. Here, the authors leverage biomaterials integration to study, and effect changes in, diffusion and electron transfer kinetics of these compounds. Specifically, the authors employ a catechol-modified chitosan film, which the authors have previously presented as the first electrochemical detection mechanism capable of quantifying clozapine directly in clinical serum. A key finding in our present work is differing dynamics between clozapine and norclozapine once the authors interface the electrodes with chitosan-based biomaterial films. These additional dimensions of redox information can thus enable selective sensing of largely analogous small molecules.
[Mh] Termos MeSH primário: Catecóis/química
Quitosana/química
Clozapina/análise
Técnicas Eletroquímicas
Membranas Artificiais
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Catechols); 0 (Membranes, Artificial); 9012-76-4 (Chitosan); J60AR2IKIC (Clozapine); LF3AJ089DQ (catechol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1116/1.4982709


  8 / 6242 MEDLINE  
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[PMID]:28745358
[Au] Autor:Zhang F; Thakur K; Hu F; Zhang JG; Wei ZJ
[Ad] Endereço:School of Food Science and Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China. china_zhangfang@163.com kumarikiran@hfut.edu.cn hufei@hfut.edu.cn zhangjianguo@hfut.edu.cn zjwei@hfut.edu.cn.
[Ti] Título:Cross-talk between 10-gingerol and its anti-cancerous potential: a recent update.
[So] Source:Food Funct;8(8):2635-2649, 2017 Aug 01.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Since time immortal, ginger, as an ancient herb, has been used throughout the world in foods and beverages due to its typical strong and pungent flavor. Besides its use as a spice, it also serves as an excellent source of several bioactive phenolics, including nonvolatile pungent compounds, such as gingerols, paradols, shogaols, and gingerones. Gingerols constitute key ingredients in fresh ginger, with the most abundant being 6-gingerol (6-G), 8-gingerol (8-G), and 10-gingerol (10-G). Many studies have investigated the various valuable pharmacological properties of these ingredients and experimentally verified the mechanistic aspects of their health effects; however, to date, most research on the anti-cancerous activities of gingerols have focused largely on 6-G. Thus, the present article deals with the number of recent studies that have indicated and highlighted the role of 10-G with respect to its cancer prevention attributes in particular and its anti-inflammatory, anti-oxidant, anti-microbial, and gastrointestinal tract protective potential in general. The purpose of this review is to provide an overview of all the experimentally validated health benefits of 10-G for nutraceutical applications. The various findings have warranted the further investigation of 10-G and its possible use in various cancer treatments as well as its promising role as a chemo-preventive agent.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Catecóis/farmacologia
Álcoois Graxos/farmacologia
Gengibre/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/química
Catecóis/química
Suplementos Nutricionais/análise
Álcoois Graxos/química
Seres Humanos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Catechols); 0 (Fatty Alcohols); 0 (Plant Extracts); 925QK2Z900 (gingerol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00844a


  9 / 6242 MEDLINE  
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[PMID]:28873658
[Au] Autor:Wu CY; Kong M; Zhang W; Long F; Zhou J; Zhou SS; Xu JD; Xu J; Li SL
[Ad] Endereço:Department of Pharmaceutical Analysis, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, People's Republic of China.
[Ti] Título:Impact of sulphur fumigation on the chemistry of ginger.
[So] Source:Food Chem;239:953-963, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ginger (Zingiberis Rhizoma), a commonly-consumed food supplement, is often sulphur-fumigated during post-harvest handling, but it remains unknown if sulphur fumigation induces chemical transformations in ginger. In this study, the effects of sulphur fumigation on ginger chemicals were investigated by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS)-based metabolomics. The results showed that sulphur fumigation significantly altered the holistic chemical profile of ginger by triggering chemical transformations of certain original components. 6-Gingesulphonic acid, previously reported as a naturally-occurring component in ginger, was revealed to be a sulphur fumigation-induced artificial derivative, which was deduced to be generated by electrophilic addition of 6-shogaol to sulphurous acid. Using UHPLC-QTOF-MS/MS extracting ion analysis with 6-gingesulphonic acid as a characteristic chemical marker, all the commercial ginger samples inspected were determined to be sulphur-fumigated. The research outcomes provide a chemical basis for further comprehensive safety and efficacy evaluations of sulphur-fumigated ginger.
[Mh] Termos MeSH primário: Gengibre
[Mh] Termos MeSH secundário: Catecóis
Cromatografia Líquida de Alta Pressão
Fumigação
Enxofre
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 70FD1KFU70 (Sulfur); 83DNB5FIRF (shogaol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  10 / 6242 MEDLINE  
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[PMID]:28873530
[Au] Autor:Si W; Chen YP; Zhang J; Chen ZY; Chung HY
[Ad] Endereço:Key Laboratory of Agricultural and Animal Products Processing and Quality Control, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China; Suzhou Polytechnic Institute of Agriculture, Suzhou, Jiangsu, China. Electronic address: swh8614@163.com.
[Ti] Título:Antioxidant activities of ginger extract and its constituents toward lipids.
[So] Source:Food Chem;239:1117-1125, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lipid oxidation-a major cause of food product deterioration-necessitates the use of food additives to inhibit food oxidation. Ginger extract (GE) has been reported to possess antioxidant properties. However, components isolated from ginger have been rarely reported to inhibit fat oxidation. Herein, antioxidant properties of GE and four pure components derived from it (6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol) were examined and their properties were compared to those of butylated hydroxytoluene. GE and the constituent components exhibited antioxidant properties that might be attributed to their hydroxyl groups and suitable solubilizing side chains. 6-Shogaol and 10-gingerol exhibited higher activity at 60°C than 6-gingerol and 8-gingerol. Low antioxidant activity was detected at high temperatures (120/180°C). Overall, GE displayed the strongest dose-dependent antioxidant properties, especially at high temperatures, thereby demonstrating that GE can be employed as a natural antioxidant in lipid-containing processed foods.
[Mh] Termos MeSH primário: Gengibre
[Mh] Termos MeSH secundário: Catecóis
Álcoois Graxos
Lipídeos
Extratos Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Fatty Alcohols); 0 (Lipids); 0 (Plant Extracts)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE



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