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Pesquisa : D02.455.426.559.389.657.166.500 [Categoria DeCS]
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  1 / 43 MEDLINE  
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[PMID]:18855681
[Au] Autor:Fu G; Pang H; Wong YH
[Ad] Endereço:Department of Biochemistry, Molecular Neuroscience Center, and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
[Ti] Título:Naturally occurring phenylethanoid glycosides: potential leads for new therapeutics.
[So] Source:Curr Med Chem;15(25):2592-613, 2008.
[Is] ISSN:0929-8673
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Natural products have long been regarded as excellent sources for drug discovery given their structure diversity and wide variety of biological activities. Phenylethanoid glycosides are naturally occurring compounds of plant origin and are structurally characterized with a hydroxyphenylethyl moiety to which a glucopyranose is linked through a glycosidic bond. To date several hundred compounds of this type have been isolated from medicinal plants and further pharmacological studies in vitro or in vivo have shown that these compounds possess a broad array of biological activities including antibacterial, antitumor, antiviral, anti-inflammatory, neuro-protective, antioxidant, hepatoprotective, immunomodulatory, and tyrosinase inhibitory actions. Given their extensive activity profile, structure-activity relationships analyses of these compounds have been performed in a number of studies to reveal potential leads for future drug design. This article will summarize the major developments in phenylethanoid glycosides-based research in the past decade. The progresses made in phytochemistry and biological activity studies of these compounds will be reviewed. Particular attention will be given to the novel structures identified to date and the prominent therapeutic values associated with these molecules.
[Mh] Termos MeSH primário: 3-Metoxi-4-Hidroxifeniletanol/química
Produtos Biológicos/farmacologia
Desenho de Drogas
Etnobotânica
Glicosídeos/farmacologia
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Anti-Infecciosos/uso terapêutico
Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/química
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Produtos Biológicos/química
Produtos Biológicos/uso terapêutico
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Inibidores Enzimáticos/uso terapêutico
Glicosídeos/química
Glicosídeos/uso terapêutico
Fitoterapia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Biological Products); 0 (Enzyme Inhibitors); 0 (Glycosides); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol)
[Em] Mês de entrada:0812
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081016
[St] Status:MEDLINE


  2 / 43 MEDLINE  
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[PMID]:17641204
[Au] Autor:Vergoz V; Schreurs HA; Mercer AR
[Ad] Endereço:Department of Zoology, University of Otago, Dunedin, New Zealand.
[Ti] Título:Queen pheromone blocks aversive learning in young worker bees.
[So] Source:Science;317(5836):384-6, 2007 Jul 20.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Queen mandibular pheromone (QMP) has profound effects on dopamine signaling in the brain of young worker honey bees. As dopamine in insects has been strongly implicated in aversive learning, we examined QMP's impact on associative olfactory learning in bees. We found that QMP blocks aversive learning in young workers, but leaves appetitive learning intact. We postulate that QMP's effects on aversive learning enhance the likelihood that young workers remain in close contact with their queen by preventing them from forming an aversion to their mother's pheromone bouquet. The results provide an interesting twist to a story of success and survival.
[Mh] Termos MeSH primário: Abelhas/fisiologia
Aprendizagem
Feromônios/fisiologia
[Mh] Termos MeSH secundário: 3-Metoxi-4-Hidroxifeniletanol/farmacologia
Animais
Comportamento Animal/efeitos dos fármacos
Encéfalo/fisiologia
Condicionamento (Psicologia)
Sinais (Psicologia)
Dopamina/fisiologia
Feminino
Aprendizagem/efeitos dos fármacos
Masculino
Odorantes
Feromônios/química
Feromônios/farmacologia
Reforço (Psicologia)
Comportamento Social
Sacarose
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pheromones); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 57-50-1 (Sucrose); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:0708
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070721
[St] Status:MEDLINE


  3 / 43 MEDLINE  
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[PMID]:16311921
[Au] Autor:Palmerini CA; Carlini E; Saccardi C; Servili M; Montedoro G; Arienti G
[Ad] Endereço:Dipartimento di Medicina Interna, Università di Perugia, Via del Giochetto, 06127, Perugia, Italy. crlpal@unipg.it
[Ti] Título:Antagonism between olive oil phenolics and nitric oxide on lymphomonocyte cytosolic calcium.
[So] Source:Mol Cell Biochem;280(1-2):181-4, 2005 Dec.
[Is] ISSN:0300-8177
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Some biological actions of olive oil phenolics (inhibition of platelet aggregation, decrease of LDL-oxidation, inhibition of bacterial growth and hypertensive action) have been attributed to NOS stimulation in endothelial cells through an increase of cytosolic calcium, notwithstanding the scavenging activity of phenolics on NO and superoxide. In this paper, we determine the concentration of cytosolic calcium in human lymphomonocytes incubated with high concentrations of NO-donors (CysNO) and we evaluate the effects of olive oil phenolics on this parameter. CysNO induces a marked decrease of cytosolic calcium; both olive oil phenolics oppose this action of CysNO. The effects of phenolics and CysNO are independent and additive.
[Mh] Termos MeSH primário: Sinalização do Cálcio/efeitos dos fármacos
Citosol/metabolismo
Monócitos/efeitos dos fármacos
Monócitos/metabolismo
Óxido Nítrico/metabolismo
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: 3-Metoxi-4-Hidroxifeniletanol/farmacologia
Interações Medicamentosas
Seres Humanos
Nifedipino/farmacologia
Doadores de Óxido Nítrico/farmacologia
Azeite de Oliva
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nitric Oxide Donors); 0 (Olive Oil); 0 (Plant Oils); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 31C4KY9ESH (Nitric Oxide); I9ZF7L6G2L (Nifedipine)
[Em] Mês de entrada:0604
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051129
[St] Status:MEDLINE


  4 / 43 MEDLINE  
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[PMID]:9472419
[Au] Autor:Mochizuki Y; Oishi M; Takasu T
[Ad] Endereço:Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
[Ti] Título:Correlations between P300 components and neurotransmitters in the cerebrospinal fluid.
[So] Source:Clin Electroencephalogr;29(1):7-9, 1998 Jan.
[Is] ISSN:0009-9155
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:P300 and cerebrospinal fluid neurotransmitter metabolites and amino acids were examined in 10 patients with Alzheimer's disease, 9 patients with vascular dementia and 10 healthy controls. A negative correlation between P300 amplitude and MHPG concentration, negative correlation between P200 and N200 latencies and norepinephrine concentration, positive correlation between N200 latency and lysine concentration and positive correlation between N100 amplitude and tyrosine concentration were statistically significant. These findings suggest that the noradrenergic system influences P300 amplitude, and that multiple systems may influence P300 components.
[Mh] Termos MeSH primário: Potencial Evocado P300
Neurotransmissores/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: 3-Metoxi-4-Hidroxifeniletanol/líquido cefalorraquidiano
Idoso
Idoso de 80 Anos ou mais
Doença de Alzheimer/líquido cefalorraquidiano
Doença de Alzheimer/fisiopatologia
Demência Vascular/líquido cefalorraquidiano
Demência Vascular/fisiopatologia
Seres Humanos
Lisina/líquido cefalorraquidiano
Meia-Idade
Norepinefrina/líquido cefalorraquidiano
Tirosina/líquido cefalorraquidiano
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotransmitter Agents); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 42HK56048U (Tyrosine); K3Z4F929H6 (Lysine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:9803
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980224
[St] Status:MEDLINE


  5 / 43 MEDLINE  
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[PMID]:8932738
[Au] Autor:Fukuhara K; Kvetnansky R; Weise VK; Ohara H; Yoneda R; Goldstein DS; Kopin IJ
[Ad] Endereço:Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
[Ti] Título:Effects of continuous and intermittent cold (SART) stress on sympathoadrenal system activity in rats.
[So] Source:J Neuroendocrinol;8(1):65-72, 1996 Jan.
[Is] ISSN:0953-8194
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We compared sympathoadrenal responses to intermittent cold (SART) stress (in which cold exposure is interrupted by 4-hourly intervals daily at room temperature) with those to continuous cold (-3 degrees C) stress. Plasma levels of dihydroxyphenylalanine (DOPA), catecholamines and their metabolites as well as tyrosine hydroxylase (TH) activities in sympathetically innervated tissues were examined in rats exposed to each stressor for 1 day or for 5 days. Neither SART nor continuous exposure to cold for 1 day or 5 days altered plasma epinephrine (EPI) levels. However, norepinephrine (NE) and dihydroxyphenylglycol (DHPG) levels increased markedly during exposure to these stressors. On the first day of SART or continuous cold stress, NE levels were increased similarly, but the increments in DHPG levels were greater during SART stress. Since DHPG is formed in neurons, neural reuptake of NE may be more enhanced on the first day of SART stress than on the first day of continuous cold stress. After 5 days of SART stress plasma NE levels were significantly higher than those found after 5 days of continuous cold exposure. Plasma levels of DHPG were elevated to the same extent in both 5 days SART- and continuously cold-stressed rats, whereas plasma levels of methoxyhydroxyphenylglycol (MHPG) increased only by 5 days SART stress. Even at 1 h after the removal from 5 days SART stress, increased plasma levels of NE, DHPG and MHPG were still evident. These results suggest that 5 days SART stress elevates extraneuronal O-methylation of DHPG, and that NE turnover is more greatly increased by SART stress than by continuous cold stress. Plasma levels of DOPA, dopamine, dihydroxyphenylacetic acid and homovanillic acid also increased after either SART or continuous cold stress for 1 day and 5 days. Adrenal TH activities were significantly increased in rats exposed to SART or continuous cold stress for 1 day and 5 days, but in brown fat TH activity was elevated only in rats exposed to 5 days of continuous cold. Both SART and continuous cold stress are selective and potent stimuli for activation of the sympathoneural system, apparently without significant adrenomedullary EPI release. The increase of TH activity in the brown fat pad as well as of plasma NE and its metabolites is probably a result of adaptation to cold. It appears that even short intervals of return to a normal environmental temperature, as in SART, are sufficient to diminish sympathetic adaptation to cold.
[Mh] Termos MeSH primário: Glândulas Suprarrenais/inervação
Estresse Fisiológico/fisiopatologia
Sistema Nervoso Simpático/fisiologia
[Mh] Termos MeSH secundário: 3-Metoxi-4-Hidroxifeniletanol/sangue
Tecido Adiposo Marrom/enzimologia
Glândulas Suprarrenais/enzimologia
Animais
Catecolaminas/sangue
Temperatura Baixa
Sistema Enzimático do Citocromo P-450/metabolismo
Di-Hidroxifenilalanina/sangue
Dopamina/sangue
Masculino
Oxigenases de Função Mista/metabolismo
Ratos
Ratos Wistar
Estresse Fisiológico/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catecholamines); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 63-84-3 (Dihydroxyphenylalanine); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.- (Mixed Function Oxygenases); EC 1.14.13.41 (cytochrome P450TYR); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:9701
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960101
[St] Status:MEDLINE


  6 / 43 MEDLINE  
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[PMID]:7738466
[Au] Autor:Wik G
[Ad] Endereço:Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
[Ti] Título:Effects of neuroleptic treatment on cortisol and 3-methoxy-4-hydroxyphenylethyl glycol levels in blood.
[So] Source:J Endocrinol;144(3):425-9, 1995 Mar.
[Is] ISSN:0022-0795
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Plasma cortisol and serum 3-methoxy-4-hydroxyphenylethyl glycol (MHPG) were determined before and after 5-6 weeks of neuroleptic treatment in patients with schizophrenia. Following drug treatment both plasma cortisol and serum MHPG levels in patients decreased and plasma cortisol levels were also lower than in unmedicated healthy controls. Indications of a relationship between the reduction of cortisol and MHPG levels were found. The data show that neuroleptic drug treatment inhibits cortisol secretion. It is speculated that this inhibition could be related to reduced noradrenergic activity.
[Mh] Termos MeSH primário: 3-Metoxi-4-Hidroxifeniletanol/sangue
Antipsicóticos/uso terapêutico
Hidrocortisona/sangue
Esquizofrenia/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Clorpromazina/uso terapêutico
Feminino
Seres Humanos
Masculino
Esquizofrenia/sangue
Sulpirida/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 7MNE9M8287 (Sulpiride); U42B7VYA4P (Chlorpromazine); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:9506
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950301
[St] Status:MEDLINE


  7 / 43 MEDLINE  
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[PMID]:1971426
[Au] Autor:Racké K; Hering B; Ziegler K
[Ad] Endereço:Pharmakologisches Institut, Universität Mainz, Federal Republic of Germany.
[Ti] Título:Lack of autoreceptor mediated regulation of the spontaneous dopamine turnover in the isolated neurointermediate lobe of the rat pituitary gland in vitro.
[So] Source:Naunyn Schmiedebergs Arch Pharmacol;341(3):182-5, 1990 Mar.
[Is] ISSN:0028-1298
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Isolated neurointermediate lobes of the rat pituitary gland were incubated in Krebs-HEPES solution and the spontaneous outflow of endogenous dopamine and its metabolites (DOPAC, HVA and MOPET) was determined by HPLC with electrochemical detection. The spontaneous outflow of dopamine metabolites (about 1500 fmol/10 min) largely exceeded that of dopamine (about 60 fmol/10 min). Apomorphine concentration-dependently (IC50, 205 nmol/l) reduced the spontaneous outflow of the dopamine metabolites. The effect of apomorphine developed slowly and was progressive over an observation period of 70 min. After 1 h of exposure to a maximall effective concentration of apomorphine (10 mumol/l), the outflow of metabolites was inhibited by 43%. The effect of apomorphine was not affected by the dopamine D2 receptor antagonist (-)-sulpiride nor by the dopamine D1 receptor antagonist SCH 23390. Neither quinpirole nor fenoldopam significantly affected the spontaneous outflow of dopamine metabolites. It was previously shown that the high rate of spontaneous outflow of dopamine metabolites from the dopaminergic nerves in the neurointermediate lobe reflects largely the immediate catabolism of newly synthesized dopamine. This high rate of spontaneous dopamine synthesis in the neurointermediate lobe is not controlled by dopamine autoreceptors. Apomorphine appears to inhibit the spontaneous dopamine turnover by an inhibition not mediated by dopamine receptors.
[Mh] Termos MeSH primário: Dopamina/metabolismo
Hipófise/metabolismo
Receptores Dopaminérgicos/metabolismo
[Mh] Termos MeSH secundário: Ácido 3,4-Di-Hidroxifenilacético/metabolismo
3-Metoxi-4-Hidroxifeniletanol/metabolismo
Animais
Apomorfina/farmacologia
Cromatografia Líquida de Alta Pressão
Dopaminérgicos/farmacologia
Eletroquímica
Feminino
Ácido Homovanílico/metabolismo
Técnicas In Vitro
Ratos
Ratos Endogâmicos
Receptores Dopaminérgicos/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dopamine Agents); 0 (Receptors, Dopamine); 102-32-9 (3,4-Dihydroxyphenylacetic Acid); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); N21FAR7B4S (Apomorphine); VTD58H1Z2X (Dopamine); X77S6GMS36 (Homovanillic Acid)
[Em] Mês de entrada:9006
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900301
[St] Status:MEDLINE


  8 / 43 MEDLINE  
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[PMID]:2515232
[Au] Autor:Hirofuji E; Tanaka S
[Ad] Endereço:Department of Orthopaedic Surgery, Kinki University School of Medicine, Osaka, Japan.
[Ti] Título:[Effects of thyrotropin-releasing hormone on neurologic recovery and biogenic amine metabolites of cerebrospinal fluid in spinal disorders].
[So] Source:Nihon Seikeigeka Gakkai Zasshi;63(11):1306-15, 1989 Nov.
[Is] ISSN:0021-5325
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:The pharmacological effects of the thyrotropin-releasing hormone (TRH) in relation to biogenic amine metabolism in cerebrospinal fluid were examined in 35 patients with various spinal disorders. Neurologic conditions before and after TRH treatment were evaluated using subjective symptoms and Frankel's classification. Biogenic amine metabolism in cerebrospinal fluid was examined before and after TRH treatment measuring the metabolites by high performance liquid chromatography with electrochemical detection. Significant decreases in metabolites of norepinephrine and dopamine were seen in most cases of spinal disorders. The amount of serotonin metabolite, however, was not changed. In many acute cases, the neurologic condition was improved, and a significant increase in the dopamine metabolite was seen in the improved cases after TRH treatment. In chronic cases, TRH treatment was not as effective as in acute cases. TRH was therefore thought to be an effective agent in the treatment of acute spinal disorders. When an increase in the dopamine metabolite is seen after TRH treatment, neurologic improvement would probably be expected.
[Mh] Termos MeSH primário: 3-Metoxi-4-Hidroxifeniletanol/líquido cefalorraquidiano
Catecóis/líquido cefalorraquidiano
Dopamina/líquido cefalorraquidiano
Ácido Homovanílico/líquido cefalorraquidiano
Doenças da Coluna Vertebral/líquido cefalorraquidiano
Hormônio Liberador de Tireotropina/farmacologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Avaliação de Medicamentos
Feminino
Seres Humanos
Masculino
Meia-Idade
Exame Neurológico
Prognóstico
Doenças da Coluna Vertebral/tratamento farmacológico
Hormônio Liberador de Tireotropina/uso terapêutico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 5Y5F15120W (Thyrotropin-Releasing Hormone); VTD58H1Z2X (Dopamine); X77S6GMS36 (Homovanillic Acid)
[Em] Mês de entrada:9003
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:891101
[St] Status:MEDLINE


  9 / 43 MEDLINE  
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Fotocópia
[PMID]:3553965
[Au] Autor:Racké K; Böhm E; Muscholl E
[Ti] Título:The role of cytoplasmic (newly synthesized) dopamine for the spontaneous and electrically evoked release of dopamine and its metabolites from the isolated neurointermediate lobe of the rat pituitary gland in vitro.
[So] Source:Naunyn Schmiedebergs Arch Pharmacol;335(1):21-7, 1987 Jan.
[Is] ISSN:0028-1298
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Isolated rat NILs were incubated in Krebs-HEPES solution. The release of dopamine and its metabolites (DOPAC, HVA and MOPET) was determined by HPLC with electrochemical detection. The spontaneous release of the sum of metabolites was about 40 times that of dopamine. The spontaneous outflow of dopamine metabolites was unaffected after inhibition of dopamine uptake (by GBR 12921) or after pretreatment with reserpine (5 mg/kg, 12 h before the experiments), but it was reduced by 50% after preincubation with the irreversible DOPA decarboxylase inhibitor, (MFMD, 10 microM, for 10 min). The combination of pretreatment with reserpine and preincubation with MFMD resulted in an 80% inhibition of the spontaneous outflow of dopamine metabolites. Treatment with reserpine caused a 98% depletion of the dopamine tissue content, whereas 60 min after exposure to MFMD the dopamine tissue content was decreased by 40%. Electrical stimulation of the pituitary stalk (3-15 Hz, in the presence of GBR 12921) caused a frequency-dependent release of dopamine. Stimulation at 7 or 15 Hz caused also a significant release of dopamine metabolites. After pretreatment with reserpine, the release of dopamine evoked by stimulation at 15 Hz was abolished, whereas the evoked release of the metabolites was only reduced by about 55%. After MFMD, the evoked release of dopamine decreased by a percentage similar to that of dopamine tissue content, but the reduction of the evoked release of metabolites was more pronounced. In conclusion, the spontaneous release of dopamine metabolites from the dopaminergic nerve endings in the NIL largely reflects the catabolism of newly synthesized dopamine.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Citoplasma/metabolismo
Dopamina/fisiologia
Hipófise/metabolismo
[Mh] Termos MeSH secundário: Ácido 3,4-Di-Hidroxifenilacético/metabolismo
3-Metoxi-4-Hidroxifeniletanol/metabolismo
Animais
Dopamina/biossíntese
Estimulação Elétrica
Feminino
Ácido Homovanílico/metabolismo
Técnicas In Vitro
Hipófise/fisiologia
Ratos
Ratos Endogâmicos
Reserpina/farmacologia
Tetrodotoxina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
102-32-9 (3,4-Dihydroxyphenylacetic Acid); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 4368-28-9 (Tetrodotoxin); 8B1QWR724A (Reserpine); VTD58H1Z2X (Dopamine); X77S6GMS36 (Homovanillic Acid)
[Em] Mês de entrada:8705
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:870101
[St] Status:MEDLINE


  10 / 43 MEDLINE  
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Fotocópia
[PMID]:3512770
[Au] Autor:Racké K; Muscholl E
[Ti] Título:Release of endogenous 3,4-dihydroxyphenylethylamine and its metabolites from the isolated neurointermediate lobe of the rat pituitary gland. Effects of electrical stimulation and of inhibition of monoamine oxidase and reuptake.
[So] Source:J Neurochem;46(3):745-52, 1986 Mar.
[Is] ISSN:0022-3042
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Isolated rat neurointermediate lobes were incubated in vitro. The release of 3,4-dihydroxyphenylethylamine (dopamine, DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and methoxyphenylethanol (MOPET) was determined by HPLC with electrochemical detection. Under resting conditions, the outflow of metabolites was 35-50 times that of DA. HVA accounted for 50%, DOPAC for 45%, and MOPET for 5% of the metabolites. Although an equivalent of 40-50% of the tissue DA content was released per hour as metabolites, the tissue DA content was not reduced after 110 min of incubation. The spontaneous outflow of DA and its metabolites was not affected by the DA uptake inhibitor GBR 12921 (100 nM). Pargyline (10 microM) caused a time-dependent decrease of all metabolites (up to 90%). In the presence of GBR 12921 and pargyline, the spontaneous outflow of DA increased sevenfold. Removal of the intermediate lobe caused a 78% reduction in tissue DA content and a corresponding reduction of the outflow of metabolites. Electrical stimulation of the pituitary stalk (0.2 ms, 10 V, 15 Hz, three times for 1 min at intervals of 1 min) induced an increase in outflow of DA and all metabolites. DA accounted for 15%, HVA for 41%, DOPAC for 32%, and MOPET for 12% of the evoked release. The electrically evoked release of DA increased fourfold in the presence of GBR 12921 or pargyline and the effects of both drugs were additive. The evoked release of metabolites was not significantly affected by GBR 12921 but completely abolished by pargyline. In conclusion, oxidative deamination and O-methylation are important pathways for the catabolism of DA in the neurointermediate lobe.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: Dopamina/metabolismo
Inibidores da Monoaminoxidase/farmacologia
Neuro-Hipófise/metabolismo
[Mh] Termos MeSH secundário: Ácido 3,4-Di-Hidroxifenilacético/metabolismo
3-Metoxi-4-Hidroxifeniletanol/metabolismo
Animais
Cromatografia Líquida de Alta Pressão
Estimulação Elétrica
Feminino
Ácido Homovanílico/metabolismo
Cinética
Pargilina/farmacologia
Piperazinas/farmacologia
Neuro-Hipófise/efeitos dos fármacos
Ratos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Monoamine Oxidase Inhibitors); 0 (Piperazines); 102-32-9 (3,4-Dihydroxyphenylacetic Acid); 2380-78-1 (3-Methoxy-4-hydroxyphenylethanol); 67469-57-2 (1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine); 9MV14S8G3E (Pargyline); VTD58H1Z2X (Dopamine); X77S6GMS36 (Homovanillic Acid)
[Em] Mês de entrada:8604
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860301
[St] Status:MEDLINE



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