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[PMID]:28745895
[Au] Autor:McCabe AJ; Arnold WA
[Ad] Endereço:Department of Civil, Environmental, and Geo- Engineering, University of Minnesota-Twin Cities , 500 Pillsbury Dr. SE, Minneapolis Minnesota 55455, United States.
[Ti] Título:Reactivity of Triplet Excited States of Dissolved Natural Organic Matter in Stormflow from Mixed-Use Watersheds.
[So] Source:Environ Sci Technol;51(17):9718-9728, 2017 Sep 05.
[Is] ISSN:1520-5851
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dissolved organic matter (DOM) quantity and composition control the rate of formation (R ) of triplet excited states of dissolved natural organic matter ( DOM*) and the efficiency of DOM* formation (the apparent quantum yield, AQY ). Here, the reactivity of DOM* in stormflow samples collected from watersheds with variable land covers is examined. Stormflow DOM reflects variability in DOM quantity and composition as a function of land cover and may be important in controlling the fate of cotransported pollutants. R and AQY were measured using 2,4,6-trimethylphenol in stormflow samples under simulated sunlight. The DOM source and composition was characterized using absorbance and fluorescence spectroscopies and high-resolution mass spectrometry. R and the total rate of light absorption by the water samples (R ) increased with the dissolved organic carbon (DOC) concentration. AQY was independent of DOC concentration, but varied with DOM source: developed land cover (4-6%) ≈ open water > vegetated land cover (3%). AQY was positively related to an index for microbial/algal DOM content and negatively related to DOM molecular weight, DOM aromaticity, and the content of polyphenols. This work demonstrates that TMP is an effective probe for the determination of R and AQY in whole water samples after accounting for the inhibition of TMP photodegradation by DOM.
[Mh] Termos MeSH primário: Cresóis/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Carbono
Monitoramento Ambiental
Compostos Orgânicos
Fotólise
Luz Solar
Zonas Úmidas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cresols); 0 (Organic Chemicals); 0 (Water Pollutants, Chemical); 7440-44-0 (Carbon); FPZ32614N6 (2,4,6-trimethylphenol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171218
[Lr] Data última revisão:
171218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1021/acs.est.7b01914


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[PMID]:28869767
[Au] Autor:Elegheert J; Brigé A; Van Beeumen J; Savvides SN
[Ad] Endereço:Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Department of Biochemistry and Microbiology, Ghent University, Belgium.
[Ti] Título:Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands.
[So] Source:FEBS Lett;591(20):3391-3401, 2017 Oct.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Shewanella oneidensis, a Gram-negative γ-proteobacterium with an extensive redox capacity, possesses four old yellow enzyme (OYE) homologs. Of these, Shewanella yellow enzyme 4 (SYE4) is implicated in resistance to oxidative stress. Here, we present a series of high-resolution crystal structures for SYE4 in the oxidized and reduced states, and in complex with phenolic ligands and the nitro-aromatic explosive picric acid. The structures unmask new features, including the identification of a binding platform for long-chain hydrophobic molecules. Furthermore, we present the first structural observation of a hydride-Meisenheimer complex of picric acid with a flavoenzyme. Overall, our study exposes the binding promiscuity of SYE4 toward a variety of electrophilic substrates and is consistent with a general detoxification function for SYE4.
[Mh] Termos MeSH primário: Anisóis/química
Proteínas de Bactérias/química
Benzaldeídos/química
Cresóis/química
NADPH Desidrogenase/química
Shewanella/química
[Mh] Termos MeSH secundário: Motivos de Aminoácidos
Anisóis/metabolismo
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Benzaldeídos/metabolismo
Sítios de Ligação
Clonagem Molecular
Cresóis/metabolismo
Cristalografia por Raios X
Escherichia coli/genética
Escherichia coli/metabolismo
Expressão Gênica
Interações Hidrofóbicas e Hidrofílicas
Isoenzimas/química
Isoenzimas/genética
Isoenzimas/metabolismo
Cinética
Ligantes
Modelos Moleculares
NADPH Desidrogenase/genética
NADPH Desidrogenase/metabolismo
Oxirredução
Estresse Oxidativo
Picratos/química
Picratos/metabolismo
Ligação Proteica
Domínios e Motivos de Interação entre Proteínas
Estrutura Secundária de Proteína
Proteínas Recombinantes/química
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Shewanella/enzimologia
Especificidade por Substrato
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Anisoles); 0 (Bacterial Proteins); 0 (Benzaldehydes); 0 (Cresols); 0 (Isoenzymes); 0 (Ligands); 0 (Picrates); 0 (Recombinant Proteins); 6HT8U7K3AM (mequinol); A49OS0F91S (picric acid); EC 1.6.99.1 (NADPH Dehydrogenase); GF3CGH8D7Z (cresol); O1738X3Y38 (4-hydroxybenzaldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12833


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[PMID]:28719879
[Au] Autor:Wang Y; Meng F; Lin Y; Duan W; Liu Q
[Ad] Endereço:Key Laboratory of Marine Environmental Science and Ecology, Ministry of Education, Ocean University of China, Qingdao, 266100, PR China.
[Ti] Título:Four types of attenuation of phenol and cresols in microcosms under simulated marine conditions: A kinetic study.
[So] Source:Chemosphere;185:595-601, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phenol, o-cresol, m-cresol, and p-cresol were selected to conduct microcosm experiments to examine their attenuation under simulated marine conditions, aiming at estimating natural attenuation and the contribution of oxidation, photolysis, biodegradation, and volatilisation to total attenuation of phenol and three cresols in the marine environment. The development of attenuation in microcosms showed the relevance of the pseudo-first-order kinetic for all phenols. The half-lives of phenol, o-cresol, m-cresol, and p-cresol attenuation under optimal conditions were 7.9, 4.3, 5.3, and 4.4 d, respectively. Attenuation kinetics was proposed to analyse the natural attenuation of phenol and cresols. The leading attenuation type of phenol, o-cresol, and p-cresol was volatilisation, and the attenuation rate constants (K ) were 0.0356, 0.0687, and 0.0710 d . Photolysis (K : 0.0584 d ) was the major attenuation type for m-cresol. Biodegradation of phenol (K : 0.0021 d ) and m-cresol (K : 0.0049 d ) were extremely inhibited. The rank between the contributions of the four types of attenuation to total attenuation differed between phenol and the three cresols. The attenuation kinetics proposed in this study possibly demonstrated the attenuation of the phenol and cresols in microcosm. This new reaction kinetics can be used in the analysis of natural attenuation of chemical substances.
[Mh] Termos MeSH primário: Cresóis/química
Modelos Químicos
Fenol/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Cresóis/análise
Ecossistema
Cinética
Fenol/análise
Fenol/metabolismo
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cresols); 0 (Water Pollutants, Chemical); 1MXY2UM8NV (4-cresol); 339NCG44TV (Phenol); YW84DH5I7U (2-cresol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


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[PMID]:28688848
[Au] Autor:Silva JRO; Santos DS; Santos UR; Eguiluz KIB; Salazar-Banda GR; Schneider JK; Krause LC; López JA; Hernández-Macedo ML
[Ad] Endereço:Laboratório de Biologia Molecular, Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, Aracaju, SE, Brazil.
[Ti] Título:Electrochemical and/or microbiological treatment of pyrolysis wastewater.
[So] Source:Chemosphere;185:145-151, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electrochemical oxidation may be used as treatment to decompose partially or completely organic pollutants (wastewater) from industrial processes such as pyrolysis. Pyrolysis is a thermochemical process used to obtain bio-oil from biomasses, generating a liquid waste rich in organic compounds including aldehydes and phenols, which can be submitted to biological and electrochemical treatments in order to minimize its environmental impact. Thus, electrochemical systems employing dimensionally stable anodes (DSAs) have been proposed to enable biodegradation processes in subsurface environments. In order to investigate the organic compound degradation from residual coconut pyrolysis wastewater, ternary DSAs containing ruthenium, iridium and cerium synthetized by the 'ionic liquid method' at different calcination temperatures (500, 550, 600 and 700 °C) for the pretreatment of these compounds, were developed in order to allow posterior degradation by Pseudomonas sp., Bacillus sp. or Acinetobacter sp. bacteria. The electrode synthesized applying 500 °C displayed the highest voltammetric charge and was used in the pretreatment of pyrolysis effluent prior to microbial treatment. Regarding biological treatment, the Pseudomonas sp. exhibited high furfural degradation in wastewater samples electrochemically pretreated at 2.0 V. On the other hand, the use of Acinetobacter efficiently degraded phenolic compounds such as phenol, 4-methylphenol, 2,5-methylphenol, 4-ethylphenol and 3,5-methylphenol in both wastewater samples, with and without electrochemical pretreatment. Overall, the results indicate that the combination of both processes used in this study is relevant for the treatment of pyrolysis wastewater.
[Mh] Termos MeSH primário: Eliminação de Resíduos Líquidos/métodos
Águas Residuais/química
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Cresóis
Técnicas Eletroquímicas
Eletrodos
Resíduos Industriais
Oxirredução
Fenol
Fenóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cresols); 0 (Industrial Waste); 0 (Phenols); 0 (Waste Water); 1MXY2UM8NV (4-cresol); 339NCG44TV (Phenol); AGG7E6G0ZC (4-ethylphenol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170710
[St] Status:MEDLINE


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[PMID]:28679151
[Au] Autor:Hakme E; Lozano A; Gómez-Ramos MM; Hernando MD; Fernández-Alba AR
[Ad] Endereço:University of Almeria, Agrifood Campus of International Excellence (ceiA3), 04120, Almería, Spain.
[Ti] Título:Non-target evaluation of contaminants in honey bees and pollen samples by gas chromatography time-of-flight mass spectrometry.
[So] Source:Chemosphere;184:1310-1319, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work presents a non-targeted screening approach for the detection and quantitation of contaminants in bees and pollen, collected from the same hive, by GC-EI-ToF-MS. It consists of a spectral library datasets search using a compound database followed by a manual investigation and analytical standard confirmation together with semi-quantitation purposes. Over 20% of the compounds found automatically by the library search could not be confirmed manually. This number of false positive detections was mainly a consequence of an inadequate ion ratio criterion (±30%), not considered in the automatic searching procedure. Eight compounds were detected in bees and pollen. They include insecticides/acaricides (chlorpyrifos, coumaphos, fluvalinate-tau, chlorfenvinphos, pyridaben, and propyl cresol) at a concentration range of 1-1207 µg kg , herbicides (oxyfluorfen) at a concentration range of 212-1773 µg kg and a growth regulator hormone (methoprene). Some compounds were detected only in pollen; such as herbicides (clomazone), insecticides/acaricides and fungicides used to control Varroa mites as benzylbenzoate, bufencarb, allethrin, permethrin, eugenol and cyprodinil. Additional compounds were detected only in bees: flamprop-methyl, 2-methylphenol (2-49 µg kg ) and naphthalene (1-23 µg kg ). The proposed method presents important advantages as it can avoid the use of an unachievable number of analytical standards considered target compounds "a priori" but not present in the analyzed samples.
[Mh] Termos MeSH primário: Abelhas/química
Monitoramento Ambiental/métodos
Poluentes Ambientais/análise
Pólen/química
Testes de Toxicidade/métodos
[Mh] Termos MeSH secundário: Acaricidas/análise
Animais
Cresóis
Fungicidas Industriais/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Herbicidas/análise
Mel/análise
Inseticidas/análise
Nitrilos
Piretrinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Cresols); 0 (Environmental Pollutants); 0 (Fungicides, Industrial); 0 (Herbicides); 0 (Insecticides); 0 (Nitriles); 0 (Pyrethrins); 364G5G03VC (fluvalinate); GF3CGH8D7Z (cresol); YW84DH5I7U (2-cresol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170707
[St] Status:MEDLINE


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[PMID]:28528271
[Au] Autor:Deltombe O; de Loor H; Glorieux G; Dhondt A; Van Biesen W; Meijers B; Eloot S
[Ad] Endereço:Renal Division - Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. Electronic address: Olivier.Deltombe@UGent.be.
[Ti] Título:Exploring binding characteristics and the related competition of different protein-bound uremic toxins.
[So] Source:Biochimie;139:20-26, 2017 Aug.
[Is] ISSN:1638-6183
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of albumin. We evaluated the binding characteristics of hippuric acid (HA), indole-3-acetic acid (IAA), indoxyl sulfate (IS), and p-cresylsulfate (pCS) by deriving a binding curve in three distinct conditions: (i) serum from healthy controls (healthy serum), (ii) blank serum from hemodialysis patients (blank HD serum; i.e. cleared from uremic toxins), and (iii) non-treated serum from HD patients (HD serum). Additionally, the mutual binding competition of these uremic toxins was studied in blank HD in pairs. In both experiments, equilibrium dialysis (37 °C, 5 h) was used to separate the free and bound fractions of each PBUT. Free and total PBUT concentrations were quantified by an ultra-high performance liquid chromatography method with tandem mass spectrometer detection and the percentage protein binding (%PB) of each PBUT was calculated. For all four compounds, the binding capacity of healthy serum was higher than blank HD serum, which was comparable to non-treated HD serum, except for HA. The competition experiments revealed that at high uremic concentrations, mutual competition was observed for the strongly bound PBUTs IS and pCS. The %PB of the weakly bound HA and IAA was lower (trend) only for the addition to blank HD serum containing the strongly bound IS or pCS. There is an intrinsic impact on protein binding in uremia, revealing a lower binding capacity, as compared to healthy controls. Competitive binding is only relevant for the strongly bound PBUTs at high uremic concentrations. In addition, at least part of the effect on binding capacity can be attributed to post-translational modifications of albumin.
[Mh] Termos MeSH primário: Diálise Renal
Insuficiência Renal Crônica/metabolismo
Albumina Sérica/metabolismo
Toxinas Biológicas/metabolismo
Uremia/fisiopatologia
[Mh] Termos MeSH secundário: Ligação Competitiva
Estudos de Casos e Controles
Cromatografia Líquida de Alta Pressão
Cresóis/metabolismo
Hipuratos/metabolismo
Seres Humanos
Indicã/metabolismo
Ácidos Indolacéticos/metabolismo
Ligação Proteica
Processamento de Proteína Pós-Traducional
Insuficiência Renal Crônica/terapia
Ésteres do Ácido Sulfúrico/metabolismo
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cresols); 0 (Hippurates); 0 (Indoleacetic Acids); 0 (Serum Albumin); 0 (Sulfuric Acid Esters); 0 (Toxins, Biological); 56M34ZQY1S (4-cresol sulfate); 6U1S09C61L (indoleacetic acid); N187WK1Y1J (Indican); TE0865N2ET (hippuric acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170522
[St] Status:MEDLINE


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[PMID]:28494222
[Au] Autor:Riefer P; Klausmeyer T; Schmidt B; Schäffer A; Schwarzbauer J
[Ad] Endereço:a Institute of Geology and Geochemistry of Petroleum and Coal , RWTH Aachen University , Aachen , Germany.
[Ti] Título:Distribution and incorporation mode of the herbicide MCPA in soil derived organo-clay complexes.
[So] Source:J Environ Sci Health B;52(8):584-599, 2017 Aug 03.
[Is] ISSN:1532-4109
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The incorporation of xenobiotics into soil, especially via covalent bonds or sequestration has a major influence on the environmental behavior including toxicity, mobility, and bioavailability. The incorporation mode of 4-chloro-2-methylphenoxyacetic acid (MCPA) into organo-clay complexes has been investigated under a low (8.5 mg MCPA/kg soil) and high (1000 mg MCPA/kg soil) applied concentration, during an incubation period of up to 120 days. Emphasis was laid on the elucidation of distinct covalent linkages between non-extractable MCPA residues and humic sub-fractions (humic acids, fulvic acids, and humin). The cleavage of compounds by a sequential chemical degradation procedure (OH , BBr , RuO , TMAH thermochemolysis) revealed for both concentration levels ester/amide bonds as the predominate incorporation modes followed by ether linkages. A possible influence of the soil microbial activity on the mode of incorporation could be observed in case of the high level samples. Structure elucidation identified MCPA as the only nonextractable substance, whereas the metabolite 4-chloro-2-methylphenol was additionally found as bioavailable and bioaccessible compound.
[Mh] Termos MeSH primário: Ácido 2-Metil-4-clorofenoxiacético/química
Poluentes do Solo/química
[Mh] Termos MeSH secundário: Ácido 2-Metil-4-clorofenoxiacético/metabolismo
Silicatos de Alumínio/química
Benzopiranos/química
Biodegradação Ambiental
Cresóis/química
Alemanha
Herbicidas/química
Herbicidas/metabolismo
Substâncias Húmicas
Solo/química
Microbiologia do Solo
Poluentes do Solo/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aluminum Silicates); 0 (Benzopyrans); 0 (Cresols); 0 (Herbicides); 0 (Humic Substances); 0 (Soil); 0 (Soil Pollutants); 0 (humin); 1302-87-0 (clay); 297V63W9RI (4-chloro-2-cresol); D888C394VO (2-Methyl-4-chlorophenoxyacetic Acid); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1080/03601234.2017.1318639


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[PMID]:28472795
[Au] Autor:Favretto G; Souza LM; Gregório PC; Cunha RS; Maciel RAP; Sassaki GL; Toledo MG; Pecoits-Filho R; Souza WM; Stinghen AEM
[Ad] Endereço:Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba, Brazil.
[Ti] Título:Role of Organic Anion Transporters in the Uptake of Protein-Bound Uremic Toxins by Human Endothelial Cells and Monocyte Chemoattractant Protein-1 Expression.
[So] Source:J Vasc Res;54(3):170-179, 2017.
[Is] ISSN:1423-0135
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Organic anion transporters (OATs) are involved in the uptake of uremic toxins such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS), which play a role in endothelial dysfunction in patients with chronic kidney diseases (CKD). In this study, we investigated the role of OAT1 and OAT3 in the uptake of PCS and IS into human endothelial cells. PCS was synthesized via p-cresol sulfation and characterized using analytical methods. The cells were treated with PCS and IS in the absence and presence of probenecid (Pb), an OAT inhibitor. Cell viability was assessed using the MTT assay. The absorbed toxins were analyzed using chromatography, OAT expression using immunocytochemistry and western blot, and monocyte chemoattractant protein-1 (MCP-1) expression using enzyme-linked immunosorbent assay. Cell viability decreased after toxin treatment in a dose-dependent manner. PCS and IS showed significant internalization after 60 min treatment, while no internalization was observed in the presence of Pb, suggesting that OATs are involved in the transport of both toxins. Immunocytochemistry and western blot demonstrated OAT1 and OAT3 expression in endothelial cells. MCP-1 expression increased after toxins treatment but decreased after Pb treatment. PCS and IS uptake were mediated by OATs, and OAT blockage could serve as a therapeutic strategy to inhibit MCP-1 expression.
[Mh] Termos MeSH primário: Quimiocina CCL2/metabolismo
Células Endoteliais/metabolismo
Proteína 1 Transportadora de Ânions Orgânicos/metabolismo
Transportadores de Ânions Orgânicos Sódio-Independentes/metabolismo
Uremia/metabolismo
[Mh] Termos MeSH secundário: Transporte Biológico
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Cresóis/metabolismo
Cresóis/toxicidade
Relação Dose-Resposta a Droga
Células Endoteliais/efeitos dos fármacos
Células Endoteliais/patologia
Seres Humanos
Indicã/metabolismo
Indicã/toxicidade
Proteína 1 Transportadora de Ânions Orgânicos/antagonistas & inibidores
Transportadores de Ânions Orgânicos Sódio-Independentes/antagonistas & inibidores
Probenecid/farmacologia
Ésteres do Ácido Sulfúrico/metabolismo
Ésteres do Ácido Sulfúrico/toxicidade
Fatores de Tempo
Regulação para Cima
Uremia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CCL2 protein, human); 0 (Chemokine CCL2); 0 (Cresols); 0 (Organic Anion Transport Protein 1); 0 (Organic Anion Transporters, Sodium-Independent); 0 (Sulfuric Acid Esters); 0 (organic anion transport protein 3); 56M34ZQY1S (4-cresol sulfate); N187WK1Y1J (Indican); PO572Z7917 (Probenecid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1159/000468542


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[PMID]:28281073
[Au] Autor:Cunha I; Torres T; Oliveira H; Martins R; McGowan T; Sheahan D; Santos MM
[Ad] Endereço:Interdisciplinary Centre of Marine and Environmental Research (CIMAR/CIIMAR), University of Porto, Rua dos Bragas 289, 4050-123, Porto, Portugal. isabel.cunha@ciimar.up.pt.
[Ti] Título:Using early life stages of marine animals to screen the toxicity of priority hazardous and noxious substances.
[So] Source:Environ Sci Pollut Res Int;24(11):10510-10518, 2017 Apr.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study provides toxicity values for early life stages (ELS) of two phylogenetically distinct marine animal taxa, the sea urchin (Paracentrotus lividus), a deuterostome invertebrate, and the turbot (Scophthalmus maximus), a vertebrate (teleost), when challenged by six hazardous and noxious substances (HNS): aniline, butyl acrylate, m-cresol, cyclohexylbenzene, hexane and trichloroethylene. The aim of the study was to provide preliminary information on toxic effects of representative and relevant priority HNS to assess the risk posed by spills to marine habitats and therefore improve preparedness and the response at the operational level. Selection criteria to include each compound in the study were (1) inclusion in the HASREP (2005) list; (2) presence on the priority list established by Neuparth et al. (2011); (3) paucity of toxicological data (TOXnet and ECOTOX) for marine organisms; (4) behaviour in the water according to the categories defined by the European Behaviour classification system (GESAMP 2002), by selecting compounds with different behaviours in water; and (5) physicochemical and toxicological properties, where available, in order to anticipate the most toxic compounds. Aniline and m-cresol were the most toxic compounds with no observed apical effect concentration (NOAEC) values for sea urchin ranging between 0.01 and 0.1 mg/L, followed by butyl acrylate and cyclohexylbenzene with NOAECs ranging between 0.1 and 1.0 mg/L and trichloroethylene with NOAEC values that were in the range between 1 and 10 mg/L, reflecting their behaviour in water, mostly vapour pressure, but also solubility and log Kow. Hexane was toxic only for turbot embryos, due to its neurotoxic effects, and not for sea urchin larvae, at concentrations in the range between 1 and 10 mg/L. The concentrations tested were of the same order of magnitude for both species, and it was observed that sea urchin embryos (length of the longest arm) are more sensitive than turbot eggs larvae (hatching and cumulative mortality rates) to the HNS tested (except hexane). For this specific compound, concentrations up to 70 mg/L were tested in sea urchin larvae and no effects were observed on the length of the larvae. Both tests were found to be complementary depending on behaviour in water and toxicity target of the compounds analysed.
[Mh] Termos MeSH primário: Cresóis
Substâncias Perigosas/farmacologia
[Mh] Termos MeSH secundário: Animais
Organismos Aquáticos/efeitos dos fármacos
Embrião não Mamífero/efeitos dos fármacos
Paracentrotus/efeitos dos fármacos
Poluentes Químicos da Água/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cresols); 0 (Hazardous Substances); 0 (Water Pollutants, Chemical); 1MXY2UM8NV (4-cresol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8663-8


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[PMID]:28188231
[Au] Autor:Rivara MB; Zelnick LR; Hoofnagle AN; Newitt R; Tracy RP; Kratz M; Weigle DS; Kestenbaum BR
[Ad] Endereço:Kidney Research Institute, Seattle, WA.
[Ti] Título:Diurnal and Long-term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion.
[So] Source:Clin Chem;63(4):915-923, 2017 Apr.
[Is] ISSN:1530-8561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The renal proximal tubule is essential for removing organic solutes and exogenous medications from the circulation. We evaluated diurnal, prandial, and long-term biological variation of 4 candidate endogenous markers of proximal tubular secretion. METHODS: We used LC-MS to measure plasma and urine concentrations of hippurate (HA), cinnamoylglycine (CMG), indoxyl sulfate (IS), and -cresol sulfate (PCS) in 25 healthy adults. We measured plasma concentrations of secreted solutes at 13 time points over a 24-h period, and again after 2 weeks and 14 weeks of follow-up. We further measured 24-h renal clearances of secreted solutes at baseline, 2 weeks, and 14 weeks. RESULTS: Plasma concentrations of secreted solutes varied over the 24-h baseline period. Diurnal variation was greatest for HA, followed by CMG, IS, and PCS. Plasma concentrations of HA ( = 0.002) and IS ( = 0.02), but not CMG and PCS, increased significantly following meals. Long-term intraindividual biological variation (CV ) in plasma concentrations of secreted solutes over 14 weeks varied from 21.8% for IS to 67.3% for PCS, and exceeded that for plasma creatinine (CV , 7.1%). Variation in 24-h renal clearances was similar among the secreted solutes [intraindividual variation (CV ), 33.6%-47.3%] and was lower using pooled plasma samples from each study visit. CONCLUSIONS: Plasma concentrations of HA, CMG, IS, and PCS fluctuate within individuals throughout the day and over weeks. Renal clearances of these secreted solutes, which serve as estimates of renal proximal tubule secretion, are also subject to intraindividual biological variation that can be improved by additional plasma measurements.
[Mh] Termos MeSH primário: Cresóis/sangue
Glicina/análogos & derivados
Hipuratos/sangue
Indicã/sangue
Túbulos Renais Proximais/metabolismo
Túbulos Renais Proximais/secreção
Ésteres do Ácido Sulfúrico/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Cromatografia Líquida
Feminino
Glicina/sangue
Seres Humanos
Túbulos Renais Proximais/química
Masculino
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Cresols); 0 (Hippurates); 0 (Sulfuric Acid Esters); 16534-24-0 (cinnamoylglycine); 56M34ZQY1S (4-cresol sulfate); N187WK1Y1J (Indican); TE0865N2ET (hippuric acid); TE7660XO1C (Glycine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1373/clinchem.2016.260117



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