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  1 / 2060 MEDLINE  
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[PMID]:28764086
[Au] Autor:Ng KL; Tan GH; Khor SM
[Ad] Endereço:Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; Wipro Skin Research and Innovation Centre, No 7 Persiaran Subang Permai, Taman Perindustrian Subang, 47610 Selangor, Malaysia.
[Ti] Título:Graphite nanocomposites sensor for multiplex detection of antioxidants in food.
[So] Source:Food Chem;237:912-920, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and tert-butylhydroquinone (TBHQ) are synthetic antioxidants used in the food industry. Herein, we describe the development of a novel graphite nanocomposite-based electrochemical sensor for the multiplex detection and measurement of BHA, BHT, and TBHQ levels in complex food samples using a linear sweep voltammetry technique. Moreover, our newly established analytical method exhibited good sensitivity, limit of detection, limit of quantitation, and selectivity. The accuracy and reliability of analytical results were challenged by method validation and comparison with the results of the liquid chromatography method, where a linear correlation of more than 0.99 was achieved. The addition of sodium dodecyl sulfate as supporting additive further enhanced the LSV response (anodic peak current, I ) of BHA and BHT by 2- and 20-times, respectively.
[Mh] Termos MeSH primário: Análise de Alimentos
Alimentos
Nanocompostos/análise
[Mh] Termos MeSH secundário: Antioxidantes
Hidroxianisol Butilado
Hidroxitolueno Butilado
Grafite
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 1P9D0Z171K (Butylated Hydroxytoluene); 25013-16-5 (Butylated Hydroxyanisole); 7782-42-5 (Graphite)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  2 / 2060 MEDLINE  
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[PMID]:28579554
[Au] Autor:Nabhani S; Schipp C; Miskin H; Levin C; Postovsky S; Dujovny T; Koren A; Harlev D; Bis AM; Auer F; Keller B; Warnatz K; Gombert M; Ginzel S; Borkhardt A; Stepensky P; Fischer U
[Ad] Endereço:Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany.
[Ti] Título:STAT3 gain-of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic compounds.
[So] Source:Clin Immunol;181:32-42, 2017 Aug.
[Is] ISSN:1521-7035
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Autoimmune lymphoproliferative syndrome (ALPS) is typically caused by mutations in genes of the extrinsic FAS mediated apoptotic pathway, but for about 30% of ALPS-like patients the genetic diagnosis is lacking. We analyzed 30 children with ALPS-like disease of unknown cause and identified two dominant gain-of-function mutations of the Signal Transducer And Activator Of Transcription 3 (STAT3, p.R278H, p.M394T) leading to increased transcriptional activity. Hyperactivity of STAT3, a known repressor of FAS, was associated with decreased FAS-mediated apoptosis, mimicking ALPS caused by FAS mutations. Expression of BCL2 family proteins, further targets of STAT3 and regulators of the intrinsic apoptotic pathway, was disturbed. Cells with hyperactive STAT3 were consequently more resistant to intrinsic apoptotic stimuli and STAT3 inhibition alleviated this effect. Importantly, STAT3-mutant cells were more sensitive to death induced by the BCL2-inhibitor ABT-737 indicating a dependence on anti-apoptotic BCL2 proteins and potential novel therapeutic options.
[Mh] Termos MeSH primário: Apoptose/genética
Síndrome Linfoproliferativa Autoimune/genética
Fator de Transcrição STAT3/genética
[Mh] Termos MeSH secundário: Compostos de Bifenilo
Hidroxitolueno Butilado/análogos & derivados
Estudos de Casos e Controles
Pré-Escolar
Ensaio de Imunoadsorção Enzimática
Família
Proteína Ligante Fas/metabolismo
Feminino
Perfilação da Expressão Gênica
Mutação em Linhagem Germinativa
Seres Humanos
Immunoblotting
Imunofenotipagem
Leucócitos Mononucleares
Linfócitos
Nitrofenóis
Piperazinas
Proteínas Proto-Oncogênicas c-bcl-2/antagonistas & inibidores
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Análise de Sequência de DNA
Sulfonamidas
Linfócitos T/efeitos dos fármacos
Linfócitos T/metabolismo
Receptor fas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ABT-737); 0 (Biphenyl Compounds); 0 (FAS protein, human); 0 (FASLG protein, human); 0 (Fas Ligand Protein); 0 (Nitrophenols); 0 (Piperazines); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (STAT3 Transcription Factor); 0 (STAT3 protein, human); 0 (Sulfonamides); 0 (fas Receptor); 1P9D0Z171K (Butylated Hydroxytoluene); 728-39-2 (BH 3)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


  3 / 2060 MEDLINE  
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[PMID]:28551227
[Au] Autor:Li J; Bi Y; Sun S; Peng D
[Ad] Endereço:Lipid Technology and Engineering, School of Food Science and Engineering, Henan University of Technology, Lianhua Road, Zhengzhou, Henan 450001, People's Republic of China. Electronic address: lijun1989730@163.com.
[Ti] Título:Simultaneous analysis of tert-butylhydroquinone, tert-butylquinone, butylated hydroxytoluene, 2-tert-butyl-4-hydroxyanisole, 3-tert-butyl-4-hydroxyanisole, α-tocopherol, γ-tocopherol, and δ-tocopherol in edible oils by normal-phase high performance liquid chromatography.
[So] Source:Food Chem;234:205-211, 2017 Nov 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A normal-phase high performance liquid chromatography method for the simultaneous determination of tert-butylhydroquinone, tert-butylquinone, butylated hydroxytoluene, 2-tert-butyl-4-hydroxyanisole, 3-tert-butyl-4-hydroxyanisole, α-tocopherol, γ-tocopherol, and δ-tocopherol in edible oils was investigated. A silica column was used to separate the analytes with the gradient elution. An ultraviolet-visible detector was set at dual wavelengths mode (280 and 310nm). The column temperature was 30°C. The analytes were directly extracted with methanol. Results showed that the normal-phase high performance liquid chromatography method performed well with wide liner ranges (0.10∼500.00µg/mL, R >0.9998), low limits of detection and quantitation (below 0.40 and 1.21µg/mL, respectively), and good recoveries (81.38∼102.34% in soybean oils and 83.03∼100.79% in lard, respectively). The reduction of tert-butylquinone caused by the reverse-phase high performance liquid chromatography during the injection was avoided with the current normal-phase method. The two isomers of butylated hydroxyanisole can also be separated with good resolution.
[Mh] Termos MeSH primário: Hidroxianisol Butilado/análise
Hidroxitolueno Butilado/análise
Óleos Vegetais/química
Quinonas/análise
Tocoferóis/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Análise de Alimentos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 0 (Quinones); 1P9D0Z171K (Butylated Hydroxytoluene); 25013-16-5 (Butylated Hydroxyanisole); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


  4 / 2060 MEDLINE  
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[PMID]:28490135
[Au] Autor:Nieva-Echevarría B; Goicoechea E; Guillén MD
[Ad] Endereço:Food Technology, Faculty of Pharmacy, Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad n° 7, 01006 Vitoria-Gasteiz, Spain.
[Ti] Título:Polyunsaturated lipids and vitamin A oxidation during cod liver oil in vitro gastrointestinal digestion. Antioxidant effect of added BHT.
[So] Source:Food Chem;232:733-743, 2017 Oct 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The extent of cod liver oil hydrolysis and oxidation during in vitro gastrointestinal digestion was investigated by Proton Nuclear Magnetic Resonance ( H NMR) and Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS). These techniques evidenced the degradation of polyunsaturated ω-3 and ω-6 lipids and, for the first time, that of vitamin A, naturally present in cod liver oil. Cis,trans-conjugated dienes associated with hydroperoxides, as well as monoepoxides, cis,trans-2,4-alkadienals, 4-hydroperoxy- and 4-hydroxy-2-alkenals, and several vitamin A derived metabolites were generated. Moreover, the effect of the addition of the synthetic antioxidant 2,6-di-tert-butyl-hydroxytoluene (BHT) at 20 and 800ppm was tackled. Both techniques showed BHT to be efficient in limiting oxidation reactions during digestion, almost inhibiting them at 800ppm. Therefore, the simultaneous intake of antioxidants with cod liver oil should be considered, in order to increase polyunsaturated lipid and vitamin A bioaccessibility and avoid formation of toxic oxidation compounds like oxygenated alpha,beta-unsaturated aldehydes.
[Mh] Termos MeSH primário: Óleo de Fígado de Bacalhau
Lipídeos
Vitamina A
[Mh] Termos MeSH secundário: Antioxidantes
Hidroxitolueno Butilado
Hidrólise
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Lipids); 11103-57-4 (Vitamin A); 1P9D0Z171K (Butylated Hydroxytoluene); 8001-69-2 (Cod Liver Oil)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


  5 / 2060 MEDLINE  
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[PMID]:28362473
[Au] Autor:Hes M; Gliszczynska-Swiglo A; Gramza-Michalowska A
[Ad] Endereço:Department of Food Service and Catering, Poznan University of Life Sciences, Poland.
[Ti] Título:The effect of antioxidants on quantitative changes of lysine and methionine in linoleic acid emulsions at different pH conditions.
[So] Source:Acta Sci Pol Technol Aliment;16(1):53-67, 2017 Jan-Mar.
[Is] ISSN:1898-9594
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Plants are an important source of phenolic compounds. The antioxidant capacities of green tea, thyme and rosemary extracts that contain these compounds have been reported earlier. However, there is a lack of accessible information about their activity against lipid oxidation in emulsions and inhibit the interaction of lipid oxidation products with amino acids. Therefore, the influence of green tea, thyme and rosemary extracts and BHT (butylated hydroxytoluene) on quantitative changes in lysine and methionine in linoleic acid emulsions at a pH of isoelectric point and a pH lower than the isoelectric point of amino acids was investigated. METHODS: Total phenolic contents in plant extracts were determined spectrophotometrically by using Folin-Ciocalteu's reagent, and individual phenols by using HPLC. The level of oxidation of emulsion was determined using the measurement of peroxides and TBARS (thiobarbituric acid reactive substances). Methionine and lysine in the system were reacted with sodium nitroprusside and trinitrobenzenesulphonic acid respectively, and the absorbance of the complexes was measured. RESULTS: Extract of green tea had the highest total polyphenol content. The system containing antioxidants and amino acid protected linoleic acid more efficiently than by the addition of antioxidants only. Lysine and methionine losses in samples without the addition of antioxidants were lower in their isoelectric points than below these points. Antioxidants decrease the loss of amino acids. The protective properties of antioxidants towards methionine were higher in a pH of isoelectric point whereas towards lysine in pH below this point. CONCLUSIONS: Green tea, thyme and rosemary extracts exhibit antioxidant activity in linoleic acid emulsions. Moreover, they can be utilized to inhibit quantitative changes in amino acids in lipid emulsions. However, the antioxidant efficiency of these extracts seems to depend on pH conditions. Further investigations should be carried out to clarify this issue.
[Mh] Termos MeSH primário: Antioxidantes/química
Lisina/análise
Metionina/análise
[Mh] Termos MeSH secundário: Hidroxitolueno Butilado/química
Emulsões
Concentração de Íons de Hidrogênio
Ácido Linoleico/análise
Extratos Vegetais/química
Polifenóis/química
Rosmarinus/química
Chá/química
Substâncias Reativas com Ácido Tiobarbitúrico/análise
Thymus (Planta)/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Emulsions); 0 (Plant Extracts); 0 (Polyphenols); 0 (Tea); 0 (Thiobarbituric Acid Reactive Substances); 1P9D0Z171K (Butylated Hydroxytoluene); 9KJL21T0QJ (Linoleic Acid); AE28F7PNPL (Methionine); K3Z4F929H6 (Lysine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.17306/J.AFS.2017.0455


  6 / 2060 MEDLINE  
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[PMID]:28272837
[Au] Autor:Hes M; Szwengiel A; Dziedzic K; Le Thanh-Blicharz J; Kmiecik D; Górecka D
[Ad] Endereço:Dept. of Food Service and Catering, Poznan Univ. of Life Sciences, Wojska Polskiego 31, 60-624, Poznan, Poland.
[Ti] Título:The Effect of Buckwheat Hull Extract on Lipid Oxidation in Frozen-Stored Meat Products.
[So] Source:J Food Sci;82(4):882-889, 2017 Apr.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the effect of antioxidants on lipid stability of frozen-stored meat products. Buckwheat hull extract was used to enrich fried meatballs made from ground pork. During 180-d storage of meat products, lipid oxidation (peroxide and 2-thiobarbituric acid reactive substances [TBARS] value) was periodically monitored. The results were compared with butylated hydroxytoluene (BHT). The addition of antioxidants decreased lipid oxidation in stored meatballs. The highest ability to control peroxide and TBARS values was demonstrated for buckwheat hull extract. Moreover, buckwheat hull extract showed a higher 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity as well as higher Fe(II) ion chelating ability, as compared with BHT. The total content of phenolic compounds are highly correlated to the individual polyphenols in extract of buckwheat hull, among which the following were assayed: 3,4-dihydroxybenzoic acid, 4-hydroxybenzoic acid, gallic acid, isovanillic acid and p-coumaric acid, and flavonoids: isoorientin, quercetin, quercetin 3-d-glucoside, rutin, and vitexin. These results indicate that plant extracts can be used to prolong shelf life of products by protecting them against lipid oxidation and deterioration of their nutritional quality.
[Mh] Termos MeSH primário: Gorduras na Dieta/análise
Fagopyrum/química
Conservação de Alimentos
Produtos da Carne/análise
[Mh] Termos MeSH secundário: Animais
Antioxidantes/análise
Hidroxitolueno Butilado/análise
Ácidos Cumáricos/análise
Fibras na Dieta/análise
Flavonoides/análise
Conservantes de Alimentos/análise
Qualidade dos Alimentos
Armazenamento de Alimentos
Congelamento
Ácido Gálico/análise
Hidroxibenzoatos/análise
Oxirredução
Parabenos/análise
Extratos Vegetais/análise
Polifenóis/análise
Propionatos
Carne Vermelha/análise
Suínos
Substâncias Reativas com Ácido Tiobarbitúrico/análise
Ácido Vanílico/análogos & derivados
Ácido Vanílico/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Coumaric Acids); 0 (Dietary Fats); 0 (Dietary Fiber); 0 (Flavonoids); 0 (Food Preservatives); 0 (Hydroxybenzoates); 0 (Parabens); 0 (Plant Extracts); 0 (Polyphenols); 0 (Propionates); 0 (Thiobarbituric Acid Reactive Substances); 1P9D0Z171K (Butylated Hydroxytoluene); 36R5QJ8L4B (protocatechuic acid); 632XD903SP (Gallic Acid); 645-08-9 (isovanillic acid); GM8Q3JM2Y8 (Vanillic Acid); IBS9D1EU3J (trans-3-(4'-hydroxyphenyl)-2-propenoic acid); JG8Z55Y12H (4-hydroxybenzoic acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13682


  7 / 2060 MEDLINE  
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[PMID]:28159281
[Au] Autor:Gholivand S; Lasekan O; Tan CP; Abas F; Wei LS
[Ad] Endereço:Department of Food Technology, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
[Ti] Título:Comparative study of the antioxidant activities of some lipase-catalyzed alkyl dihydrocaffeates synthesized in ionic liquid.
[So] Source:Food Chem;224:365-371, 2017 Jun 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The solubility limitations of phenolic acids in many lipidic environments are now greatly improved by their enzymatic esterification in ionic liquids (ILs). Herein, four different ILs were tested for the esterification of dihydrocaffeic acid with hexanol and the best IL was selected for the synthesis of four other n-alkyl esters with different chain-lengths. The effect of alkyl chain length on the anti-oxidative properties of the resulted purified esters was investigated using ß-carotene bleaching (BCB) and free radical scavenging method DPPH and compared with butylated hydroxytoluene (BHT) as reference compound. All four esters (methyl, hexyl, dodecyl and octadecyl dihydrocaffeates) exhibited relatively strong radical scavenging abilities. The scavenging activity of the test compounds was in the following order: methyl ester>hexyl ester⩾dodecyl ester>octadecyl ester>BHT while the order for the BCB anti-oxidative activity was; BHT>octadecyl ester>dodecyl ester>hexyl ester>methyl ester.
[Mh] Termos MeSH primário: Antioxidantes/química
Ácidos Cafeicos/química
Íons/química
Lipase/metabolismo
[Mh] Termos MeSH secundário: Hidroxitolueno Butilado/química
Catálise
Esterificação
Hidroxibenzoatos/química
beta Caroteno/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Caffeic Acids); 0 (Hydroxybenzoates); 0 (Ions); 01YAE03M7J (beta Carotene); 1078-61-1 (3,4-dihydroxyphenylpropionic acid); 1P9D0Z171K (Butylated Hydroxytoluene); 29656-58-4 (phenolic acid); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


  8 / 2060 MEDLINE  
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[PMID]:28159244
[Au] Autor:Tao J; Zhu Q; Qin F; Wang M; Chen J; Zheng ZP
[Ad] Endereço:State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, People's Republic of China.
[Ti] Título:Preparation of steppogenin and ascorbic acid, vitamin E, butylated hydroxytoluene oil-in-water microemulsions: Characterization, stability, and antibrowning effects for fresh apple juice.
[So] Source:Food Chem;224:11-18, 2017 Jun 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Oil-in-water microemulsions (O/W MEs) allow the preparation of insoluble compounds into liquid. In this study, we prepared O/W MEs to improve the solubility and stability of steppogenin (S) in aqueous liquid, and studied their ability to inhibit fresh apple juice browning. The ME technique greatly increased steppogenin solubility up to 3000-fold higher than that in water. All SMEs demonstrated good stability after acceleration and long-term storage. In particular, 0.01% SME was associated with dramatic inhibition of fresh apple juice browning after 24h at room temperature and 7days at 4°C, and its antibrowning effects were further improved when combined with 0.05% ascorbic acid. On the other hand, simultaneous encapsulation of steppogenin with vitamin E or butylated hydroxytoluene into ME did not greatly improve SME antibrowning effects. Taken together, these results suggested that steppogenin might serve as a potential antibrowning agent to preserve fresh apple juice.
[Mh] Termos MeSH primário: Ácido Ascórbico/farmacologia
Hidroxitolueno Butilado/farmacologia
Emulsões/farmacologia
Malus/efeitos dos fármacos
Vitamina E/farmacologia
[Mh] Termos MeSH secundário: Ácido Ascórbico/análise
Hidroxitolueno Butilado/análise
Emulsões/química
Solubilidade
Vitamina E/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Emulsions); 1406-18-4 (Vitamin E); 1P9D0Z171K (Butylated Hydroxytoluene); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


  9 / 2060 MEDLINE  
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[PMID]:28105861
[Au] Autor:Noman L; Oke-Altuntas F; Zellagui A; Sahin Yaglioglu A; Demirtas I; M Cardoso S; Akkal S; Gherraf N; Rhouati S
[Ad] Endereço:a Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, Faculty of Science , University of Mentouri-Constantine , Constantine , Algeria.
[Ti] Título:A novel benzimidazole and other constituents with antiproliferative and antioxidant properties from Thymelaea microphylla Coss. et Dur.
[So] Source:Nat Prod Res;31(17):2032-2041, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new compound (microphybenzimidazole, 7) along with the six known compounds matairesinol (1), prestegane B (2), umbelliferone (3), daphnoretin (4), microphynolide A (5) and microphynolide B (6) were isolated from Thymelaea microphylla. The structures of the pure compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR, and HPLC-TOF/MS. Compounds 2 and 4, as well as three fractions (F6, F6-C5, and F6-W42) obtained from a 50% (v:v) CH Cl :MeOH extract exhibited a selective activity against rat brain glioma cells (C6). Moreover, compound 1 and other fractions obtained from 50% (v:v) CH Cl :MeOH and 70% (v:v) MeOH:H O extracts exhibited dose- and time-dependent effects on human cervical cancer cell (HeLa), as measured by xCELLigence assay. Compound 2 (IC = 14.0 ± 0.2 µg/mL) and fraction F5 (IC = 12.4 ± 0.1 µg/mL) showed higher radical scavenging ability than the synthetic agent butylated hydroxytoluene (BHT, IC = 22.7 ± 0.6 µg/mL).
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Benzimidazóis/química
Thymelaeaceae/química
[Mh] Termos MeSH secundário: 4-Butirolactona/análogos & derivados
4-Butirolactona/química
4-Butirolactona/farmacologia
Animais
Antineoplásicos Fitogênicos/química
Antioxidantes/química
Benzimidazóis/farmacologia
Hidroxitolueno Butilado/farmacologia
Linhagem Celular Tumoral
Cromatografia Líquida de Alta Pressão
Cumarínicos/química
Cumarínicos/farmacologia
Relação Dose-Resposta a Droga
Furanos/química
Furanos/farmacologia
Células HeLa
Seres Humanos
Lignanas/química
Lignanas/farmacologia
Estrutura Molecular
Ratos
Metabolismo Secundário
Thymelaeaceae/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Benzimidazoles); 0 (Coumarins); 0 (Furans); 0 (Lignans); 0 (microphybenzimidazole); 1P9D0Z171K (Butylated Hydroxytoluene); 2034-69-7 (daphnoretin); 580-72-3 (matairesinol); 93376-04-6 (prestegane B); OL659KIY4X (4-Butyrolactone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1274888


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[PMID]:27916495
[Au] Autor:Liu R; Lin Y; Ruan T; Jiang G
[Ad] Endereço:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Occurrence of synthetic phenolic antioxidants and transformation products in urban and rural indoor dust.
[So] Source:Environ Pollut;221:227-233, 2017 Feb.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, seven synthetic phenolic antioxidant (SPA) analogues were positively found in urban and rural indoor dust samples collected from Shandong province in China, among which the novel 2,4,6-tri-tert-butylphenol (AO 246), 2,6-di-tert-butyl-4-sec-butylphenol (DTBSBP), 2,4-di-tert-butylphenol (DBP) and 4,4'-butylidenebis (2-(1,1-dimethylethyl)-5- methyl-phenol) (AO 44B25) analogues accounted for 29% of total SPA concentrations (∑SPAs). Urban dust showed significantly higher ∑SPA levels (range: 1.56e3 - 2.03e4 ng/g) compared with those in rural indoor dust (668-4.39e3 ng/g, p < 0.05). 2,6-Di-tert-butyl-4-methylphenol (BHT) was the dominate analogue in the urban indoor dust, which constituted of 74% in ΣSPAs. While, varied composition profiles of SPAs were noticed in rural indoor dust, for instance, AO 246 (46%) and BHT (43%) had similar contributions to ∑SPAs. Three BHT transformation products (TPs) were also detected in most of the urban and rural dust samples (>97%), with individual residue level in the same order: 2,6-di-tert-butyl-1,4-benzoquinone (BHT-Q) > 2,6-di-tert-butyl-4-hydroxy- 4-methyl-2,5-cyclo-hexadienone (BHT-quinol) > 3,5-di-tert-butyl-4-hydroxybenzal-dehyde (BHT-CHO). Geometric mean values of total TP concentrations were 555 ng/g and 131 ng/g for urban and rural indoor dust samples, respectively. A preliminary estimated daily intake calculation at dust ingestion scenario suggested additional concerns might be paid to simultaneous exposure of several SPA analogues and TPs besides current focus on BHT exposure risks.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Poluição do Ar em Ambientes Fechados/análise
Antioxidantes/análise
Monitoramento Ambiental
Fenóis/análise
[Mh] Termos MeSH secundário: Benzaldeídos
Benzoquinonas
Hidroxitolueno Butilado/análogos & derivados
China
Cidades
Poeira/análise
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2,6-di-tert-butyl-4-methylphenol); 0 (Air Pollutants); 0 (Antioxidants); 0 (Benzaldehydes); 0 (Benzoquinones); 0 (Dust); 0 (Phenols); 1P9D0Z171K (Butylated Hydroxytoluene); 3T006GV98U (quinone); 95VTI93VUL (3,5-di-tert-butyl-4-hydroxybenzaldehyde); 99J2VIC675 (2,4,6-tri-tert-butylphenol); FOB94G6HZT (2,4-di-tert-butylphenol); O81VMW36CV (butylphen)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE



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