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[PMID]:27688174
[Au] Autor:He XP; Lian ZR; Tan LJ; Wang JT
[Ad] Endereço:Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao, 266100, PR China.
[Ti] Título:Preparation and characterization of magnetic molecularly imprinted polymers for selective trace extraction of dienestrol in seawater.
[So] Source:J Chromatogr A;1469:8-16, 2016 Oct 21.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Highly selective and efficient magnetic molecularly imprinted polymers (MMIPs) were prepared using Fe O @SiO as a magnetic supporter, 3-methacryloxypropyltrimethoxy-silane (MPS) as a silane coupling agent, DIS as a template, methacrylic acid (MAA) as a functional monomer and ethyleneglycol dimethacrylate (EGDMA) as a cross-linker for the extraction of trace residuals of the synthetic estrogen dienestrol (DIS) in seawater, which is a concern worldwide for its endocrine disruption and carcinogenic danger to human health. The obtained MMIPs were demonstrated to have spherical morphologies, core-shell structures, large binding capacities, high efficiency and selectivity. These were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and adsorption experiments. Owing to the specific binding sites, the MMIPs exhibited an almost three times higher adsorption capacity towards DIS (Q =4.68mgg ) than magnetic molecularly non-imprinted polymers (MNIPs) (Q =1.72mgg ). DIS in spiked seawater samples from the Weihai Bay of China was extracted and enriched by MMIPs, and satisfactory recoveries (87.3%-96.4%) with low relative standard deviation (RSD) values (2.03%-5.18%, n=5) were obtained. The limit of detection (LOD) of the method obtained was 0.16µgL , and the limit of quantitation was 0.52µgL after MMIPs. No significant deterioration of the adsorption capacity of the MMIPs was observed after six rounds of regeneration. The results further demonstrated the applicability of the MMIPs method, a simple and straightforward method for the extraction and enrichment of DIS in seawater without any time-consuming procedures.
[Mh] Termos MeSH primário: Dienestrol/isolamento & purificação
Congêneres do Estradiol/isolamento & purificação
Nanopartículas de Magnetita/química
Poluentes Químicos da Água/isolamento & purificação
[Mh] Termos MeSH secundário: Adsorção
China
Seres Humanos
Limite de Detecção
Microscopia Eletrônica de Transmissão
Impressão Molecular
Água do Mar/química
Silanos/química
Dióxido de Silício/química
Microextração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estradiol Congeners); 0 (Magnetite Nanoparticles); 0 (Silanes); 0 (Water Pollutants, Chemical); 7631-86-9 (Silicon Dioxide); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE


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[PMID]:25188907
[Au] Autor:He X; Xi C; Tang B; Wang G; Chen D; Peng T; Mu Z
[Ad] Endereço:a College of Pharmacy , Chongqing Medical University , Yuzhong District , Chongqing , China.
[Ti] Título:Simultaneous determination of 30 hormones illegally added to anti-ageing functional foods using UPLC-MS/MS coupled with SPE clean-up.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;31(10):1625-38, 2014.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel analytical method employing solid-phase extraction (SPE) coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous determination of 30 hormones in anti-ageing functional foods (capsules, powders and tablets). The analytes were extracted with acetic acid-acetonitrile (1-99 v/v), methanol and acetone, respectively. The extract was purified using a combined column, followed by analyte detection with electrospray ionisation in positive- or negative-ion modes. The results indicated that the 30 compounds had good linear correlations in the range of 1-1000 µg kg⁻¹, and the correlation coefficients were above 0.99. The limits of detection (LOD) and limits of quantification (LOQ) were 0.03-2 and 0.1-5 µg kg⁻¹, respectively. The average recovery of 30 compounds at the three spiked levels varied from 74.7% to 124.1%, and the relative standard deviation (RSD) was 2.4-15.0%. This method was applied to the analysis of hormones in 14 real samples of which seven hormones (such as estrone, dienestrol) were detected in four samples, but the remainder of the hormones were not detected. The developed method is sensitive, efficient, reliable and applicable to real samples.
[Mh] Termos MeSH primário: Antioxidantes/química
Suplementos Nutricionais/análise
Contaminação de Alimentos
Inspeção de Alimentos/métodos
Hormônios/análise
[Mh] Termos MeSH secundário: Senilidade Prematura/prevenção & controle
Métodos Analíticos de Preparação de Amostras
Antioxidantes/economia
Antioxidantes/normas
China
Cromatografia Líquida de Alta Pressão
Dienestrol/análise
Dienestrol/química
Suplementos Nutricionais/economia
Suplementos Nutricionais/normas
Estrogênios/análise
Estrogênios/química
Estrogênios não Esteroides/análise
Estrogênios não Esteroides/química
Estrona/análise
Estrona/química
Fidelidade a Diretrizes
Hormônios/química
Limite de Detecção
Estrutura Molecular
Reprodutibilidade dos Testes
Extração em Fase Sólida
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Antioxidants); 0 (Estrogens); 0 (Estrogens, Non-Steroidal); 0 (Hormones); 2DI9HA706A (Estrone); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:141009
[Lr] Data última revisão:
141009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140905
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2014.953602


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[PMID]:24822457
[Au] Autor:Li L; Su M; Shi X; Wang Y; Wang M; He J
[Ti] Título:[Determination of estrogen residues in drinking water by on-line solid phase extraction based on sol-gel technique coupled with high performance liquid chromatography].
[So] Source:Se Pu;32(2):194-7, 2014 Feb.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A method for the determination of diethylstilbestrol (DES), hexestrol (HEX) and dienestrol (DS) residues in drinking water was established by on-line solid phase extraction (SPE) coupled with high performance liquid chromatography (HPLC). The material synthesized on the base of sol-gel technology was employed as adsorbent. This material was prepared using 3-aminopropyltriethoxysilane (APTES) as the functional monomer, tetraethoxysilane (TEOS) as the crosslinking agent, and acetic acid as the initiator. The synthesized adsorbent showed outstanding property for the estrogen extraction. The estrogen can be caught effectively from water samples and the extraction can be achieved rapidly. Some important parameters, such as pH of sample solution, eluent solvents, loading flow rate, which might influence extraction efficiency, were optimized. The results indicated that the limit of detection (S/N = 3) of the developed method could reach 0.07-0.13 microg/L under the conditions of pH 7.0 of sample solution, methanol and 1% (v/v) acetic acid aqueous solution as the eluent solvent and the loading flow rate of 2 mL/min. The recoveries of the three estrogens from the water samples at three spiked levels ranged from 82.31% to 99.43% with RSD of 1.61%-7.15%. The method was simple, rapid, and suitable to detect the trace residues of estrogens in drinking water.
[Mh] Termos MeSH primário: Água Potável/análise
Estrogênios/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Dienestrol
Dietilestilbestrol
Hexestrol
Polimetil Metacrilato
Propilaminas
Silanos
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 0 (Estrogens); 0 (Propylamines); 0 (Silanes); 0 (Water Pollutants, Chemical); 10BI795R7D (Hexestrol); 42064KRE49 (tetraethoxysilane); 731DCA35BT (Diethylstilbestrol); 9011-14-7 (Polymethyl Methacrylate); L8S6UBW552 (amino-propyl-triethoxysilane); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140515
[St] Status:MEDLINE


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[PMID]:24636894
[Au] Autor:Hu WY; Kang XJ; Zhang C; Yang J; Ling R; Liu EH; Li P
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China; Nanjing Bureau of Quality and Technical Supervision, Nanjing, PR China.
[Ti] Título:Packed-fiber solid-phase extraction coupled with high performance liquid chromatography-tandem mass spectrometry for determination of diethylstilbestrol, hexestrol, and dienestrol residues in milk products.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;957:7-13, 2014 Apr 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A sensitive analytical method based on packed-fiber solid-phase extraction and high performance liquid chromatography-tandem mass spectrometry (PF SPE-HPLC-MS/MS) has been developed for determination of three synthetic stilbenes in milk. The stilbenes are extracted with acetonitrile, using sodium chloride, and purified with PF SPE using a cartridge containing electrospun polystyrene nanofibers. Parameters affecting the efficiency of PF SPE, such as pH and amount of salt, were optimized. Under optimal conditions, the limits of detection and quantification were 5-13pg/g and 15-37pg/g, respectively. Absolute recoveries varied between 60% and 85% at three different levels. The method was successfully applied for the determination of estrogenic stilbenes in a total of 69 milk samples. The method is sensitive and cost-effective in stilbene detection, and has potential in quality control of dairy products.
[Mh] Termos MeSH primário: Dienestrol/análise
Dietilestilbestrol/análise
Hexestrol/análise
Leite/química
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/métodos
Dienestrol/química
Dienestrol/isolamento & purificação
Dietilestilbestrol/química
Dietilestilbestrol/isolamento & purificação
Hexestrol/química
Hexestrol/isolamento & purificação
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
10BI795R7D (Hexestrol); 731DCA35BT (Diethylstilbestrol); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140401
[Lr] Data última revisão:
140401
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140319
[St] Status:MEDLINE


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[PMID]:23451515
[Au] Autor:Nong S; Lin F; Huang X; Yuan D
[Ad] Endereço:State Key Laboratory of Marine Environmental Science, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China.
[Ti] Título:Preparation of a stir bar sorptive extraction coating based on molecularly imprinted polymer and its application in the extraction of dienestrol and hexestrol in complicated samples.
[So] Source:Se Pu;30(11):1133-42, 2012 Nov.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:A new stir bar sorptive extraction (SBSE) coating based on molecularly imprinted polymer (MIP) with diethylstilbestrol as replaced template molecule was prepared. The influences of the contents of template molecule and monomer in the polymerization mixture on the extraction performance of MIP-SBSE were investigated thoroughly. The MIP was characterized by elemental analysis, scanning electron microscopy and infrared spectroscopy. In order to evaluate the usability of the new coating, the MIP-SBSE was combined with high performance liquid chromatography (HPLC) and diode array detector (DAD) with dienestrol (DS) and hexestrol (HS) as detected solutes. To achieve optimally selective extraction performance for DS and HS, several parameters, including extraction and desorption times, desorption solvent, ionic strength and pH value in sample matrix were investigated. The results showed that under the optimized experimental conditions, the present method has high selectivity and sensitivity. When drying-redissolving procedure was taken during sample preparation, the limits of detection for DS and HS were as low as 0.04 microg/L and 0.14 micorg/L, respectively. Good linearities were obtained for analytes with the correlation coefficients (R2) above 0.99. Finally, the proposed method was successfully applied to the determination of DS and HS in wastewater, honey and cow urine samples. The recoveries of spiked target compounds in real samples ranged from 61.3% to 120%. The developed method is simple, selective, sensitive and applicable for the analysis of trace DS and HS in complicated samples.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Dienestrol/análise
Hexestrol/análise
Impressão Molecular
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Adsorção
Fracionamento Químico/métodos
Dienestrol/isolamento & purificação
Hexestrol/isolamento & purificação
Polímeros/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers); 10BI795R7D (Hexestrol); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130305
[St] Status:MEDLINE


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[PMID]:23424876
[Au] Autor:Chen X; Yao S; Li X; Zhao Y; Jin M
[Ad] Endereço:Ningbo Municipal Center for Disease Control and Prevention, Ningbo Key Laboratory of Poison Research and Control, Ningbo 315010, China. chenxhnb@163.com
[Ti] Título:[Simultaneous determination of nine estrogens in eel by ultrafast liquid chromatography-tandem mass spectrometry with isotope dilution technique and solid-phase extraction].
[So] Source:Wei Sheng Yan Jiu;41(6):956-62, 2012 Nov.
[Is] ISSN:1000-8020
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: Developing a rapid and sensitive analytical method based on ultrafast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) with solid-phase extraction (SPE) for the simultaneous determination of nine estrogens (dienestrol, diethylstilbestrol, estrone, hexestrol, 17-alpha-estradiol, 17-beta-estradiol, estriol, 17alpha-ethinylestradiol and estradiol valerate) in eel. METHODS: After the sample was extracted by acetonitrile and cleaned by Waters Oasis HLB solid-phase extraction cartridge, the UFLC separation was performed on a Shim-pack XR-ODS II column (100 mm x 2.0 mm, 2.2 microm) with a linear gradient elution program of methanol solution containing 0.04% ammonia (v/v) and 0.04% ammonia aqueous solution (v/v) as the mobile phase. Electrospray ionization was applied and operated in the negative multiple reaction monitoring (MRM) mode. The quantitation was used by isotope internal standard dilution technique. RESULTS: The results showed that the limits of quantitation (LOQs, S/N(10) were in the range of 0.07-0.4 microg/kg, the calibration curves were in good linearities for the nine analytes in the range of 0.5-50.0 microg/L with the correlative coefficients (r2) more than 0.998, the recoveries were between 81.0% and 110.0% with the relative standard deviations (RSDs) of 1.92%-8.24%. Additional, the mass spectra characterization of the nine estrogens was discussed and the fragmentation pathways were speculated. CONCLUSION: The developed method is rapid, sensitive, specific and reproducible, and adapts not only to the simultaneous determination of the nine trace estrogens including the epimer of 17-alpha-estradiol and 17-beta-estradiol but also to the identified detection in other fish tissues.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Enguias
Estrogênios/análise
Produtos Pesqueiros/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Dienestrol/análise
Dietilestilbestrol/análise
Estrona/análise
Contaminação de Alimentos/análise
Técnica de Diluição de Radioisótopos
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Estrogens); 2DI9HA706A (Estrone); 731DCA35BT (Diethylstilbestrol); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:130221
[Lr] Data última revisão:
130221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130222
[St] Status:MEDLINE


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[PMID]:23189660
[Au] Autor:Zhao Y; Chen X; Yao S; Li X; Jin M
[Ad] Endereço:Ningbo Key Laboratory of Poison Research and Control, Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010. China.
[Ti] Título:[Analysis of six phenolic environmental estrogens in bullfrog blood by using dispersive solid-phase extraction and ultrafast liquid chromatography-tandem mass spectrometry].
[So] Source:Se Pu;30(7):665-71, 2012 Jul.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A rapid, sensitive and accurate method for the simultaneous determination of six phenolic environmental estrogens, i. e., bisphenol A (BPA), diethylstilbestrol (DES), dienestrol( DE), hexestrol (HEX), 4-( tert-octyl)-phenol (4-tOP) and 4-nonylphenol (4-NP) in bullfrog blood by dispersive solid-phase extraction-ultrafast liquid chromatography-tandem mass spectrometry (dSPE-UFLC-MS/MS) was established. After protein precipitation, bullfrog blood samples were cleaned-up by dSPE method with ethylenediamine-functionalized Fe3O4, magnetic polymers (EDA-MPs) as adsorbent. The effects of precipitation solvents, adsorption time and the amount of EDA-MPs used on the recoveries of six phenolic environmental estrogens were investigated in detail. Chromatographic separation was performed on a Shim-pack XR-ODS II analytical column (100 mm x 2.0 mm, 2.2 microm). The mass spectrometer was operated by using electrospray ion (ESI) source in the multiple reaction monitoring (MRM) mode. The results showed that the linearities were in the range of 0.5-100.0 microg/L with correlation coefficients (r2) not less than 0.999 6 for all the six phenolic environmental estrogens. The lim- its of quantification (LOQs) (S/N > 10) in bullfrog blood samples were between 0. 075 microg/L and 0.40 microg/L. The recoveries were between 95.0% and 110.0% at three spiked levels. The precision values expressed as relative standard deviations (RSDs) were in the range of 0.6%-6.3%. The developed method can be applied to the routine analysis of the six phenolic environmental estrogens in bullfrog blood samples.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Poluentes Ambientais/sangue
Estrogênios não Esteroides/sangue
Fenóis/sangue
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Compostos Benzidrílicos/sangue
Dienestrol/sangue
Dietilestilbestrol/sangue
Rana catesbeiana/sangue
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Environmental Pollutants); 0 (Estrogens, Non-Steroidal); 0 (Phenols); 731DCA35BT (Diethylstilbestrol); MLT3645I99 (bisphenol A); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1308
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121130
[St] Status:MEDLINE


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[PMID]:21994916
[Au] Autor:Xu Q; Wang M; Yu S; Tao Q; Tang M
[Ad] Endereço:Ministry of Education Key Laboratory of Environmental Medicine and Engineering, School of Public Health, Southeast University, Nanjing, 210009, China.
[Ti] Título:Trace analysis of diethylstilbestrol, dienestrol and hexestrol in environmental water by Nylon 6 nanofibers mat-based solid-phase extraction coupled with liquid chromatography-mass spectrometry.
[So] Source:Analyst;136(23):5030-7, 2011 Dec 07.
[Is] ISSN:1364-5528
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A simple, rapid and sensitive method for the determination of diethylstilbestrol (DES), dienestrol (DE) and hexestrol (HEX) was developed by using the Nylon 6 nanofibers mat-based solid-phase extraction (SPE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS). These estrogens were separated within 8 min by LC using an ODS column and methanol/water (80/20, v/v) at a flow rate of 1.0 mL min(-1). Electrospray ionization conditions in the negative ion mode were optimized for MS detection of the estrogens. Under the optimum SPE conditions, all target analytes in 50 mL environmental water samples can be completely extracted by 1.5 mg Nylon 6 nanofibers mat at flow rate of 3.0 mL min(-1) and easily eluted by passage of 500 µL mobile phase. By using the novel SPE-LC/MS method, good linearity of the calibration curve (r(2) ≥ 0.9992) was obtained in the concentration range from 0.10 ng L(-1) to 1.0 mg L(-1) (except for DE which was 0.20 ng L(-1) to 1.0 mg L(-1)) for all analytes examined. The limits of detection (S/N = 3) of the three estrogens ranged from 0.05 ng L(-1) to 0.10 ng L(-1). This method was applied successfully to the analysis of environmental water samples without any other pretreatment and interference peaks. Several water samples were collected from Jinchuan River and Xuanwu Lake, and in Jinchuan River water DES was detected at 0.13 ng L(-1). The recoveries of estrogens spiked into tap water were above 98.2%, and the relative standard deviations were below 4.78%.
[Mh] Termos MeSH primário: Dienestrol/análise
Dietilestilbestrol/análise
Hexestrol/análise
Lagos/análise
Nanofibras
Rios/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Caprolactama/análogos & derivados
Cromatografia Líquida/métodos
Dienestrol/isolamento & purificação
Dietilestilbestrol/isolamento & purificação
Hexestrol/isolamento & purificação
Lagos/química
Espectrometria de Massas/métodos
Polímeros
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers); 0 (Water Pollutants, Chemical); 10BI795R7D (Hexestrol); 25038-54-4 (nylon 6); 6879X594Z8 (Caprolactam); 731DCA35BT (Diethylstilbestrol); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1205
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:111014
[St] Status:MEDLINE
[do] DOI:10.1039/c1an15494j


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[PMID]:19811643
[Au] Autor:Roner MR; Carraher CE; Shahi K; Ashida Y; Barot G
[Ad] Endereço:Department of Biology, University of Texas, Arlington, TX 76010, USA. roner@uta.edu
[Ti] Título:Ability of Group IVB metallocene polyethers containing dienestrol to arrest the growth of selected cancer cell lines.
[So] Source:BMC Cancer;9:358, 2009 Oct 07.
[Is] ISSN:1471-2407
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Monomeric Group IVB (Ti, Zr and Hf) metallocenes represent a new class of antitumor compounds. There is literature on the general biological activities of some organotin compounds. Unfortunately, there is little information with respect to the molecular level activity of these organotin compounds. We recently started focusing on the anti-cancer activity of organotin polymers that we had made for other purposes and as part of our platinum anti-cancer effort. METHODS: For this study, we synthesized a new series of metallocene-containing compounds coupling the metallocene unit with dienestrol, a synthetic, nonsteroidal estrogen. This is part of our effort to couple known moieties that offer antitumor activity with biologically active units hoping to increase the biological activity of the combination. The materials were confirmed to be polymeric using light scattering photometry and the structural repeat unit was verified employing matrix assisted laser desorption ionization mass spectrometry and infrared spectroscopy results. RESULTS: The polymers demonstrated the ability to suppress the growth of a series of tumor cell lines originating from breast, colon, prostrate, and lung cancers at concentrations generally lower than those required for inhibition of cell growth by the commonly used antitumor drug cisplatin. CONCLUSION: These drugs show great promise in vitro against a number of cancer cell lines and due to their polymeric nature will most likely be less toxic than currently used metal-containing drugs such as cisplatin. These drugs also offer several addition positive aspects. First, the reactants are commercially available so that additional synthetic steps are not needed. Second, synthesis of the polymer is rapid, occurring within about 15 seconds. Third, the interfacial synthetic system is already industrially employed in the synthesis of aromatic nylons and polycarbonates. Thus, the ability to synthesize large amounts of the drugs is straight forward.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Dienestrol/farmacologia
Neoplasias/fisiopatologia
Compostos Organometálicos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Linhagem Celular Tumoral
Dienestrol/química
Seres Humanos
Neoplasias/tratamento farmacológico
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Organometallic Compounds); 0 (metallocene); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:1001
[Cu] Atualização por classe:141207
[Lr] Data última revisão:
141207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091009
[St] Status:MEDLINE
[do] DOI:10.1186/1471-2407-9-358


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[PMID]:18350830
[Au] Autor:Kaplanskii AS; Durnova GN
[Ti] Título:[Role of insufficient hormone production in development of osteopenia in consequence of physical loads defficiency].
[So] Source:Aviakosm Ekolog Med;41(6):13-7, 2007 Nov-Dec.
[Is] ISSN:0233-528X
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Experiments with rats deprived of support loading on hind limbs by tail-suspension showed that injection of hormones participating in bone metabolism impeded the development of tibial spongy osteopenia; also, normalization of longitudinal bone growth was observed in several cases. Investigations were aimed to evaluate the effectiveness of growth hormone, sex hormones, thyreoid hormones, calcitonin, CNS stimulating ephedrine and strychnine, and graded support loads. The best results were obtained after injection of calcitonin combined with sinestrol (synthetic analog of estradiol) and graded support loads which acted as initiators and amplifiers of hormonal effects. The combination of calcitonin, sinestrol and support loads prevented osteopenia and provided the normal bone growth in length during rat's suspension.
[Mh] Termos MeSH primário: Conservadores da Densidade Óssea/uso terapêutico
Doenças Ósseas Metabólicas/tratamento farmacológico
Doenças Ósseas Metabólicas/etiologia
Calcitonina/uso terapêutico
Dienestrol/uso terapêutico
Estrogênios não Esteroides/uso terapêutico
Hormônio do Crescimento/deficiência
Hormônio do Crescimento/uso terapêutico
Atividade Motora
[Mh] Termos MeSH secundário: Anabolizantes/uso terapêutico
Animais
Doenças Ósseas Metabólicas/complicações
Hipocinesia/complicações
Nandrolona/análogos & derivados
Nandrolona/uso terapêutico
Ratos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anabolic Agents); 0 (Bone Density Conservation Agents); 0 (Estrogens, Non-Steroidal); 6PG9VR430D (Nandrolone); 9002-72-6 (Growth Hormone); 9007-12-9 (Calcitonin); H45187T098 (nandrolone decanoate); RRW32X4U1F (Dienestrol)
[Em] Mês de entrada:0805
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:080321
[St] Status:MEDLINE



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