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[PMID]:28159275
[Au] Autor:Jin R; Li L; Guo L; Li W; Shen Q
[Ad] Endereço:Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
[Ti] Título:A graphene tip coupled with liquid chromatography tandem mass spectrometry for the determination of four synthetic adulterants in slimming supplements.
[So] Source:Food Chem;224:329-334, 2017 Jun 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Slimming supplements were popularly sold online driven by the increasement of obesity and the development of social networking platform. However, events of drug abuse in slimming supplements were also frequently reported. In this study, a graphene tip solid-phase extraction (Gtip SPE) and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was established for determining fenfluramine, phenolphthalein, bumetanide, and sibutramine in slimming supplements. It was validated in terms of linearity (0.9985-0.9995), LOD (1.8ngmL ), LOQ (5.6ngmL ), intra-day precision (<5.1%), inter-day precision (<7.3%), and recovery (82.9-95.2%). Sibutramine is the most commonly used drug, which was detected in Bihais, Galong, and Aolist, with content 12.4, 3.6, 20.3mgg , respectively. Phenolphthalein was also found with content lower than 5.2mgg . The successful application of Gtip SPE and UPLC-MS/MS method indicated its advantage in analyzing low level of contaminates resulted from violation of regulation.
[Mh] Termos MeSH primário: Depressores do Apetite/análise
Cromatografia Líquida
Suplementos Nutricionais/análise
Grafite/química
Espectrometria de Massas em Tandem
[Mh] Termos MeSH secundário: Bumetanida/análise
Ciclobutanos/análise
Fenfluramina/análise
Limite de Detecção
Fenolftaleína/análise
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Appetite Depressants); 0 (Cyclobutanes); 0Y2S3XUQ5H (Bumetanide); 2DS058H2CF (Fenfluramine); 6QK969R2IF (Phenolphthalein); 7782-42-5 (Graphite); WV5EC51866 (sibutramine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170205
[St] Status:MEDLINE


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[PMID]:28116777
[Au] Autor:Every-Palmer S; Newton-Howes G; Clarke MJ
[Ad] Endereço:Wellington School of Medicine, University of Otago, Wellington, New Zealand.
[Ti] Título:Pharmacological treatment for antipsychotic-related constipation.
[So] Source:Cochrane Database Syst Rev;1:CD011128, 2017 01 24.
[Is] ISSN:1469-493X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antipsychotic-related constipation is a common and serious adverse effect, especially for people taking clozapine. Clozapine has been shown to impede gastrointestinal motility, leading to constipation, and has been reported in up to 60% of patients receiving clozapine. In rare cases, complications can be fatal. Appropriate laxatives should be prescribed to treat constipation in people taking antipsychotics, but there is a lack of guidance on the comparative effectiveness and harms of different agents in this population. An understanding of the effectiveness and safety of treatment for antipsychotic-related constipation is important for clinicians and patients alike. OBJECTIVES: To evaluate the effectiveness and safety of pharmacologic treatment (versus placebo or compared against another treatment) for antipsychotic-related constipation (defined as constipated patients of any age, who are treated with antipsychotics, regardless of dose, in which constipation is considered to be an antipsychotic-related side effect). SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (15 June 2015), which is based on regular searches of MEDLINE, Embase, CINAHL, BIOSIS, AMED, PubMed, PsycINFO, and registries of clinical trials, grey literature, and conference proceedings. There are no language, date, document type, or publication status limitations for inclusion of records in this register. We also handsearched bibliographies and contacted relevant authors for additional information. SELECTION CRITERIA: We included all published and unpublished randomised controlled trials (RCTs) investigating the efficacy of pharmacological treatments in patients with antipsychotic-related constipation. Pharmacological treatments included laxatives and other medicines that could reasonably be used to combat constipation in this population (e.g. anticholinergic agents, like bethanecol). DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data from all included studies and assessed trials for risk of bias. A third author reviewed 20% of trials. We analysed dichotomous data using relative risks (RR) and the 95% confidence intervals (CI). We assessed risk of bias for included studies and used GRADE to create a 'Summary of findings' table. We discussed any disagreement, documented decisions, and attempted to contact study authors when necessary. MAIN RESULTS: We identified two relevant Chinese studies (N = 480) that contributed data to this review. Both studies were over ten years old and poorly reported, lacking descriptions of contemporary CONSORT reporting prerequisites, such as sequence generation, allocation concealment, blinding, participant flow, how the sample size was determined, or how outcomes were measured. The studies also did not report trial registration, pre-specified protocols, consent processes, ethical review, or funding source. We were unsuccessful in making contact with the authors to clarify the missing details. We classified both studies as having an overall high risk of bias.One study compared glycerol suppository with the traditional Chinese medicine (TCM) approaches of tuina massage and acupuncture. Compared to tuina massage, glycerol laxative was less effective in relieving constipation at both two days after treatment (1 RCT; N = 120; RR 2.88, 95% CI 1.89 to 4.39; very low-quality evidence), and three days (1 RCT; N = 120; RR 4.80, CI 1.96 to 11.74, very low-quality evidence). Favourable results were also seen for acupuncture at two days (1 RCT; N = 120; RR 3.50; 95% CI 2.18 to 5.62; very low-quality evidence), and at three days (1 RCT; N = 120; RR 8.00, 95% CI 2.54 to 25.16; very low-quality evidence).The other study compared mannitol, an osmotic laxative, with rhubarb soda or phenolphthalein. Mannitol was more effective than rhubarb soda or phenolphthalein in trelieving constipation within 24 hours of treatment (1 RCT; N = 240; RR 0.07; 95% CI 0.02 to 0.27, very low-quality evidence).No data were reported for our other important outcomes: need for rescue medication, bowel obstruction (a complication of antipsychotic-related constipation), quality of life, adverse events, leaving the study early, and economic costs. AUTHORS' CONCLUSIONS: We had hoped to find clinically useful evidence appraising the relative merits of the interventions routinely used to manage antipsychotic-related constipation, a common and potentially serious adverse effect of the use of these drugs. The results were disappointing. There were no data comparing the common pharmacological interventions for constipation, such as lactulose, polyethylene glycol, stool softeners, lubricant laxatives, or of novel treatments such as linaclotide. Data available were very poor quality and the trials had a high risk of bias. Data from these biased studies suggested that mannitol, an osmotic laxative, was more effective than rhubarb soda and phenolphthalein in relieving constipation, and a two-week course of glycerol suppositories was less effective than the TCM approaches of tuina massage and acupuncture.Overall, there is insufficient trial-based evidence to assess the effectiveness and safety of pharmacological interventions for treating antipsychotic-related constipation, due to limited, poor quality data (few studies with high risk of bias and no meta-analyses). The methodological limitations in the included studies were obvious, and any conclusions based on their results should be made with caution. Methodologically rigorous RCTs evaluating interventions for treating antipsychotic-related constipation are needed.
[Mh] Termos MeSH primário: Antipsicóticos/efeitos adversos
Constipação Intestinal/tratamento farmacológico
Glicerol/uso terapêutico
Laxantes/uso terapêutico
Manitol/uso terapêutico
Fenolftaleína/uso terapêutico
Rheum
[Mh] Termos MeSH secundário: Terapia por Acupuntura
Constipação Intestinal/induzido quimicamente
Seres Humanos
Massagem/métodos
Ensaios Clínicos Controlados Aleatórios como Assunto
Supositórios
[Pt] Tipo de publicação:JOURNAL ARTICLE; META-ANALYSIS; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Laxatives); 0 (Suppositories); 3OWL53L36A (Mannitol); 6QK969R2IF (Phenolphthalein); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1002/14651858.CD011128.pub2


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[PMID]:27612798
[Au] Autor:Castro DO; Tabary N; Martel B; Gandini A; Belgacem N; Bras J
[Ad] Endereço:Univ. Grenoble Alpes, LGP2, F-38000 Grenoble, France; CNRS, LGP2, F-38000 Grenoble, France. Electronic address: danieleocastro@gmail.com.
[Ti] Título:Effect of different carboxylic acids in cyclodextrin functionalization of cellulose nanocrystals for prolonged release of carvacrol.
[So] Source:Mater Sci Eng C Mater Biol Appl;69:1018-25, 2016 Dec 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Current investigations deal with new surface functionalization strategy of nanocrystalline cellulose-based substrates to impart active molecule release properties. In this study, cellulose nanocrystals (CNC) were surface-functionalized with ß-cyclodextrin (ß-CD) using succinic acid (SA) and fumaric acid (FA) as bridging agents. The main objective of this surface modification performed only in aqueous media was to obtain new active materials able to release antibacterial molecules over a prolonged period of time. The reactions were conducted by immersing the CNC film into a solution composed of ß-CD, SA and FA, leading to CNC grafting. The materials were characterized by infrared spectroscopy (FT-IR), Quartz crystal microbalance-dissipation (QCM-D), AFM and phenolphthalein (PhP) was used to determine the efficiency of CNC grafting with ß-CD. The results indicated that ß-CD was successfully attached to the CNC backbone through the formation of ester bonds. Furthermore, carvacrol was entrapped by the attached ß-CD and a prolonged release was confirmed. In particular, CNC grafted to ß-CD in the presence of FA was selected as the best solution. The antibacterial activity and the controlled release were studied for this sample. Considerably longer bacterial activity against B. subtilis was observed for CNC grafted to ß-CD compared to CNC and CNC-FA, confirming the promising impact of the present strategy.
[Mh] Termos MeSH primário: Ácidos Carboxílicos/química
Celulose/química
Monoterpenos/farmacologia
Nanopartículas/química
beta-Ciclodextrinas/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bacillus subtilis/efeitos dos fármacos
Preparações de Ação Retardada
Liberação Controlada de Fármacos
Microscopia de Força Atômica
Peso Molecular
Fenolftaleína/química
Técnicas de Microbalança de Cristal de Quartzo
Espectroscopia de Infravermelho com Transformada de Fourier
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Carboxylic Acids); 0 (Delayed-Action Preparations); 0 (Monoterpenes); 0 (beta-Cyclodextrins); 6QK969R2IF (Phenolphthalein); 9004-34-6 (Cellulose); 9B1J4V995Q (carvacrol); JV039JZZ3A (betadex)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160911
[St] Status:MEDLINE


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[PMID]:27143234
[Au] Autor:Wilson P; Masse C
[Ti] Título:Detection of Synthetic Drugs as Adulterants in Natural and Herbal Slimming Products by LC-ESI-MS/MS with Polarity Switching.
[So] Source:J AOAC Int;99(4):929-40, 2016 Jul.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to develop an LC-tandem MS method for the simultaneous detection of common synthetic drugs as adulterants in natural and herbal slimming products. Sixteen drugs belonging to a wide range of pharmaceutical classes were studied. Included in the list of drugs were anorexics, anxiolytics, antidepressants, diuretics, laxatives, and stimulants. The method used a C18 column (4.6 × 50 mm and 1.8 µm particle size). Separation of the drugs was achieved by gradient elution using 4 mM ammonium formate in water + 0.1% formic acid as the aqueous component and 4 mM ammonium formate in methanol + 0.1% formic as the organic component of the mobile phase. As not all of the analytes ionized in the positive mode, the mass spectrometer was operated in the electrospray ionization mode with polarity switching. The samples were extracted with methanol and the use of 50% acetonitrile in water and 50% methanol in water were investigated as diluents for injection into the LC-MS system. Utilizing both diluents, the validation parameters including accuracy, precision, LOD, and LOQ were assessed. The validation results and utilization of the method to analyze a variety of weight-loss supplements indicate that the two diluents give similar results and can be used interchangeably. This knowledge provides the user with the option of selecting either diluent for sample preparation depending on the sample matrix without having to revalidate the method. The method was applied to the analysis of weight-loss supplements available in local pharmacies, herbal pharmacies, and over the Internet.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/análise
Contaminação de Medicamentos
Preparações de Plantas/análise
[Mh] Termos MeSH secundário: Cafeína/análise
Cromatografia Líquida
Ciclobutanos/análise
Fenolftaleína/análise
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Cyclobutanes); 0 (Plant Preparations); 3G6A5W338E (Caffeine); 6QK969R2IF (Phenolphthalein); WV5EC51866 (sibutramine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160505
[St] Status:MEDLINE
[do] DOI:10.5740/jaoacint.15-0295


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[PMID]:26990564
[Au] Autor:Luedeke M; Miller E; Sprague JE
[Ad] Endereço:Ohio Attorney General's Bureau of Criminal Investigation, Bowling Green, OH, United States; The Ohio Attorney General's Center for the Future of Forensic Science, Bowling Green State University, Bowling Green, OH, United States.
[Ti] Título:Technical note: The effects of Bluestar(®) and luminol when used in conjunction with tetramethylbenzidine or phenolphthalein.
[So] Source:Forensic Sci Int;262:156-9, 2016 May.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:There are numerous presumptive tests available in the forensic science field to help identify the presence of blood. While many articles are available on the effects of Bluestar(®) and luminol and potential interactions with subsequent DNA identification, the research field falls short in identifying the effects these two presumptive tests may have on subsequent presumptive tests used to help identify blood. To rectify this ongoing issue in the forensic science field, the chemiluminescence methods of Bluestar(®) and luminol for the detection of blood at a crime scene were tested for their effects when used in conjunction with tetramethylbenzidine (TMB) or phenolphthalein (PT) at the forensic science laboratory. Six different substrates (untreated wood, pressure treated wood, ceramic tile, shag carpet, cement block, and cotton clothing) were stained with varying dilutions (range 1:1 to 1:100,000) of blood. Neither luminol nor Bluestar(®) affect the results of PT or TMB tests at blood dilutions equal to or less than 1:100. However, interactions did occur between agents and substrates with blood dilutions 1:1000 or greater. Bluestar(®) was the only presumptive test that can detect blood dilutions of 1:100,000 on some substrates and luminol was inclusive on pressure treated wood. These findings suggests that forensic science laboratory personal need to know and understand the details of how the blood was detected by the crime scene investigator and the substrate on which the blood was obtained from for their preparation of presumptive blood testing with PT or TMB.
[Mh] Termos MeSH primário: Benzidinas
Manchas de Sangue
Substâncias Luminescentes
Luminol
Fenolftaleína
[Mh] Termos MeSH secundário: Medicina Legal
Seres Humanos
Indicadores e Reagentes
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzidines); 0 (Indicators and Reagents); 0 (Luminescent Agents); 3B3T5CB8EO (3,3',5,5'-tetramethylbenzidine); 5EXP385Q4F (Luminol); 6QK969R2IF (Phenolphthalein)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170202
[Lr] Data última revisão:
170202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE


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[PMID]:26572363
[Au] Autor:Udoetok IA; Dimmick RM; Wilson LD; Headley JV
[Ad] Endereço:Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan S7N 5C9, Canada.
[Ti] Título:Adsorption properties of cross-linked cellulose-epichlorohydrin polymers in aqueous solution.
[So] Source:Carbohydr Polym;136:329-40, 2016 Jan 20.
[Is] ISSN:1879-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cellulose was cross-linked with epichlorohydrin (EP) at variable levels (CLE-0.5, CLE-2 and CLE-4), where CLE-i denotes the cellulose to EP mole ratios. The cross-linked products were characterized by TGA and FT-IR spectroscopy, pH at the point of zero charge (pHpzc), water swelling, and dye-adsorption methods employing two types of dyes [phenolphthalein (phth) and p-nitrophenol (PNP)]. The characterization methods provide evidence of cross-linking of cellulose in accordance with variations in surface area, PZC, available surface hydroxyl groups, and thermal stability when compared against pristine cellulose. The pHpzc of the sorbent materials was ∼ 6.5 indicating a negative surface charge occurs above pHpzc. The cross-linked polymers possess greater swelling properties relative to pristine cellulose. Detailed adsorption studies were carried out at pH 9 for cellulose and CLE-i with five types single component carboxylate anions [2-hexyldecanoic acid (S1), trans-4-pentylcyclohexanecarboxylic acid (S2), 2-dicyclohexylacetic acid (S3), adamantane carboxylic acid (S4), and cyclohexane carboxylic acid (S5)] at 295 K. The uptake properties of PNP with cellulose and CLE-i were also compared at pH 5 and 9, respectively. CLE-2 had the highest uptake of PNP (Qm=1.22 × 10(-1)mmol/g, pH 9) and S1 (Qm=4.27 mg/g) while cellulose and CLE-4 had the strongest binding affinity (1.43 L/mmol and 5.90 × 10(-2)L/mg), respectively. Uptake of PNP by CLE-0.5 at pH 5 (Q m=5.30 × 10(-2)mmol/g) was higher than uptake at pH 9 (Qm=3.11 × 10(-2)mmol/g). Sorption of CLE-4 with S1, S2 and S3 showed that relative uptake of the surrogates had the following order: S3>S2>S1, where S2 had the strongest binding affinity to CLE-i. CLE-2 had the highest sorption capacity towards Si in an equimolar mixture with evidence of molecular selective uptake. At pH 9, low uptake was mainly related to electrostatic repulsion between the negatively charged sorbent surface and the carboxylate head groups of Si.
[Mh] Termos MeSH primário: Celulose/química
Epicloroidrina/química
Polímeros/química
Água/química
[Mh] Termos MeSH secundário: Adsorção
Cor
Modelos Moleculares
Conformação Molecular
Fenolftaleína/química
Soluções
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polymers); 0 (Solutions); 059QF0KO0R (Water); 08OOR508C0 (Epichlorohydrin); 6QK969R2IF (Phenolphthalein); 9004-34-6 (Cellulose)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151117
[Lr] Data última revisão:
151117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151118
[St] Status:MEDLINE


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[PMID]:25906829
[Au] Autor:Liang B; Zou J; Su J
[Ad] Endereço:Department of Clinical Pharmacology, Dongguan People's Hospital, Dongguan, China.
[Ti] Título:What makes the phenolphthalein still be a safe drug for patients in China?
[So] Source:Pharmacoepidemiol Drug Saf;24(5):555-7, 2015 May.
[Is] ISSN:1099-1557
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Constipação Intestinal/tratamento farmacológico
Laxantes/efeitos adversos
Fenolftaleína/efeitos adversos
[Mh] Termos MeSH secundário: China
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia
Seres Humanos
Laxantes/administração & dosagem
Laxantes/uso terapêutico
Educação de Pacientes como Assunto
Fenolftaleína/administração & dosagem
Fenolftaleína/uso terapêutico
Inquéritos e Questionários
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Laxatives); 6QK969R2IF (Phenolphthalein)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150424
[Lr] Data última revisão:
150424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150425
[St] Status:MEDLINE
[do] DOI:10.1002/pds.3777


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[PMID]:25863375
[Au] Autor:Rooney JS; McDowell A; Strachan CJ; Gordon KC
[Ad] Endereço:Department of Chemistry, MacDiarmid Institute, Dodd-Walls Centre, University of Otago, Dunedin 9016, New Zealand.
[Ti] Título:Evaluation of vibrational spectroscopic methods to identify and quantify multiple adulterants in herbal medicines.
[So] Source:Talanta;138:77-85, 2015 Jun 01.
[Is] ISSN:1873-3573
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To counter the growth of herbal medicines adulterated with pharmaceuticals crossing borders, rapid, inexpensive and non-destructive analytical techniques, that can handle complex matrices, are required. Since mid-infrared (MIR), near infrared (NIR) and Raman spectroscopic techniques meet these criteria, their performance in identifying adulterants in seized weightloss herbal medicines is definitively determined. Initially a validated high pressure liquid chromatography methodology was used for reference identification and quantification of the adulterants sibutramine H2O·HCl, fenfluramine HCl and phenolphthalein. Of 38 products, only sibutramine and phenolphthalein were detected by HPLC. The spectroscopic measurements showed Raman was ill-suited due to sample burning and emission while NIR lacked adulterant selectivity. Conversely, MIR demonstrated apt identification performance, which manifested as spectrally meaningful separation based on the presence and type of adulterant during principal component analysis (test set validated). Partial least squares regression models were constructed from the MIR training sets for sibutramine and phenolphthalein - both models fitted the training set data well. Average test set prediction errors were 0.8% for sibutramine and 2.2% for phenolphthalein over the respective concentration ranges of 1.7-11.7% and 0.9-34.4%. MIR is apposite for the screening of anorectic and laxative adulterants and is the most viable technique for wider adulterant screening in herbal medicines.
[Mh] Termos MeSH primário: Suplementos Nutricionais/análise
Contaminação de Medicamentos
Medicina Herbária
Plantas Medicinais/química
Espectrofotometria Infravermelho/métodos
Análise Espectral Raman/métodos
[Mh] Termos MeSH secundário: Ciclobutanos/análise
Seres Humanos
Fenolftaleína/análise
Análise de Componente Principal
Vibração
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cyclobutanes); 6QK969R2IF (Phenolphthalein); WV5EC51866 (sibutramine)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150413
[Lr] Data última revisão:
150413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150413
[St] Status:MEDLINE


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[PMID]:25655631
[Au] Autor:Czupryna J; Kachur AV; Blankemeyer E; Popov AV; Arroyo AD; Karp JS; Delikatny EJ
[Ad] Endereço:Small Animal Imaging Facility, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
[Ti] Título:Cerenkov-specific contrast agents for detection of pH in vivo.
[So] Source:J Nucl Med;56(3):483-8, 2015 Mar.
[Is] ISSN:1535-5667
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: We report the design, testing, and in vivo application of pH-sensitive contrast agents designed specifically for Cerenkov imaging. Radioisotopes used for PET emit photons via Cerenkov radiation. The multispectral emission of Cerenkov radiation allows for selective bandwidth quenching, in which a band of photons is quenched by absorption by a functional dye. Under acidic conditions, (18)F-labeled derivatives emit the full spectrum of Cerenkov light. Under basic conditions, the dyes change color and a wavelength-dependent quenching of Cerenkov emission is observed. METHODS: Mono- and di-(18)F-labeled derivatives of phenolsulfonphthalein (phenol red) and meta-cresolsulfonphthalein (cresol purple) were synthesized by electrophilic fluorination. Cerenkov emission was measured at different wavelengths as a function of pH in vitro. Intramolecular response was measured in fluorinated probes and intermolecular quenching by mixing phenolphthalein with (18)F-FDG. Monofluorocresol purple (MFCP) was tested in mice treated with acetazolamide to cause urinary alkalinization, and Cerenkov images were compared with PET images. RESULTS: Fluorinated pH indicators were produced with radiochemical yields of 4%-11% at greater than 90% purity. Selective Cerenkov quenching was observed intramolecularly with difluorophenol red or monofluorocresol purple and intermolecularly in phenolphthalein (18)F-FDG mixtures. The probes were selectively quenched in the bandwidth closest to the indicator's absorption maximum (λmax) at pHs above the indicator pKa (the negative logarithm of the acid dissociation constant). Addition of acid or base to the probes resulted in reversible switching from unquenched to quenched emission. In vivo, the bladders of acetazolamide-treated mice exhibited a wavelength-dependent quenching in Cerenkov emission, with the greatest reduction occurring near the λmax. Ratiometric imaging at 2 wavelengths showed significant decreases in Cerenkov emission at basic pH and allowed the estimation of absolute pH in vivo. CONCLUSION: We have created contrast agents that selectively quench photons emitted during Cerenkov radiation within a given bandwidth. In the presence of a functional dye, such as a pH indicator, this selective quenching allows for a functional determination of pH in vitro and in vivo. This method can be used to obtain functional information from radiolabeled probes using multimodal imaging. This approach allows for the imaging of nonfluorescent chromophores and is generalizable to any functional dye that absorbs at suitable wavelengths.
[Mh] Termos MeSH primário: Meios de Contraste/química
Radioisótopos de Flúor/química
Fenolsulfonaftaleína/análogos & derivados
Radioisótopos/química
[Mh] Termos MeSH secundário: Acetazolamida/química
Animais
Modelos Animais de Doenças
Fluordesoxiglucose F18
Concentração de Íons de Hidrogênio
Camundongos
Modelos Químicos
Imagem Multimodal
Óptica e Fotônica
Fenolftaleína/química
Fenolsulfonaftaleína/química
Fótons
Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Contrast Media); 0 (Fluorine Radioisotopes); 0 (Radioisotopes); 0 (Radiopharmaceuticals); 0 (monofluorocresol purple); 0Z5B2CJX4D (Fluorodeoxyglucose F18); 6QK969R2IF (Phenolphthalein); I6G9Y0J1OJ (Phenolsulfonphthalein); O3FX965V0I (Acetazolamide)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150207
[St] Status:MEDLINE
[do] DOI:10.2967/jnumed.114.146605


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[PMID]:25247833
[Au] Autor:Reeuwijk NM; Venhuis BJ; de Kaste D; Hoogenboom RL; Rietjens IM; Martena MJ
[Ad] Endereço:a Netherlands Food and Consumer Product Safety Authority (NVWA) , Consumer and Safety Division , Utrecht , the Netherlands.
[Ti] Título:Active pharmaceutical ingredients detected in herbal food supplements for weight loss sampled on the Dutch market.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;31(11):1783-93, 2014.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herbal food supplements claiming to reduce weight may contain active pharmacological ingredients (APIs) that can be used for the treatment of overweight and obesity. The aim of this study was to determine whether herbal food supplements for weight loss on the Dutch market contain APIs with weight loss properties. Herbal food supplements intended for weight loss (n = 50) were sampled from August 2004 to May 2013. An HPLC-DAD-MS/MS method was used to screen for the presence of the APIs in herbal supplements. In 24 samples the APIs sibutramine, desmethylsibutramine (DMS), didesmethylsibutramine (DDMS), rimonabant, sildenafil and/or the laxative phenolphthalein were identified 41 times. The presence of these APIs was, however, not stated on the label. The potential pharmacological effects of the detected APIs were estimated using data from reported effective doses of approved drugs. Use of 20 of the 24 herbal food supplements may result in potential pharmacological effects. Furthermore, risk assessment of phenolphthalein, a suspected carcinogen and found to be present in 10 supplements, based on the margin of exposure (MOE) approach, resulted in MOE values of 96-30,000. MOE values lower than 10,000 (96-220) were calculated for the daily intake levels of four out of these 10 supplements in which phenolphthalein was found. However, taking into account that weight loss preparations may be used for only a few weeks or months rather than during a lifetime, MOE values may be two to three orders of magnitude higher. The current study shows that the use of food supplements with sibutramine, DMS, DDMS and/or phenolphthalein could result in pharmacological effects.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/análise
Suplementos Nutricionais/análise
Obesidade/dietoterapia
Perda de Peso
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Análise de Alimentos
Seres Humanos
Países Baixos
Fenolftaleína/análise
Fenolftaleína/toxicidade
Medição de Risco
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 6QK969R2IF (Phenolphthalein)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141112
[Lr] Data última revisão:
141112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140924
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2014.958574



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