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Pesquisa : D02.455.426.559.389.657.800 [Categoria DeCS]
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  1 / 978 MEDLINE  
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[PMID]:28273402
[Au] Autor:Dorla E; Gauvin-Bialecki A; Deuscher Z; Allibert A; Grondin I; Deguine JP; Laurent P
[Ad] Endereço:Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion, Avenue René Cassin-CS, 92003-97744, Saint-Denis Cedex 9, France.
[Ti] Título:Insecticidal Activity of the Leaf Essential Oil of Peperomia borbonensis Miq. (Piperaceae) and Its Major Components against the Melon Fly Bactrocera cucurbitae (Diptera: Tephritidae).
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The essential oil from the leaves of Peperomia borbonensis from Réunion Island was obtained by hydrodistillation and characterized using GC-FID, GC/MS and NMR. The main components were myristicin (39.5%) and elemicin (26.6%). The essential oil (EO) of Peperomia borbonensis and its major compounds (myristicin and elemicin), pure or in a mixture, were evaluated for their insecticidal activity against Bactrocera cucurbitae (Diptera: Tephritidae) using a filter paper impregnated bioassay. The concentrations necessary to kill 50% (LC ) and 90% (LC ) of the flies in three hours were determined. The LC value was 0.23 ± 0.009 mg/cm and the LC value was 0.34 ± 0.015 mg/cm for the EO. The median lethal time (LT ) was determined to compare the toxicity of EO and the major constituents. The EO was the most potent insecticide (LT  = 98 ± 2 min), followed by the mixture of myristicin and elemicin (1.4:1) (LT  = 127 ± 2 min) indicating that the efficiency of the EO is potentiated by minor compounds and emphasizing one of the major assets of EOs against pure molecules.
[Mh] Termos MeSH primário: Inseticidas/isolamento & purificação
Óleos Voláteis/química
Peperomia/química
Folhas de Planta/química
Tephritidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Compostos de Benzil/isolamento & purificação
Compostos de Benzil/toxicidade
Dioxolanos/isolamento & purificação
Dioxolanos/toxicidade
Dípteros/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Inseticidas/farmacologia
Espectroscopia de Ressonância Magnética
Pirogalol/análogos & derivados
Pirogalol/isolamento & purificação
Pirogalol/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzyl Compounds); 0 (Dioxolanes); 0 (Insecticides); 0 (Oils, Volatile); 01Y4A2QXY0 (Pyrogallol); 04PD6CT78W (myristicin); 487-11-6 (elemicin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600493


  2 / 978 MEDLINE  
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[PMID]:28260107
[Au] Autor:Zhao Q; Liu C; Shen X; Xiao L; Wang H; Liu P; Wang L; Xu H
[Ad] Endereço:Department of Orthopedic Surgery, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui 241001, P.R. China.
[Ti] Título:Cytoprotective effects of myristicin against hypoxia­induced apoptosis and endoplasmic reticulum stress in rat dorsal root ganglion neurons.
[So] Source:Mol Med Rep;15(4):2280-2288, 2017 Apr.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The aim of the present study was to investigate the role of myristicin (Myr; 1­allyl­5­methoxy­3,4­methylenedioxybenzene), an active aromatic compound isolated from nutmeg, carrot, basil, cinnamon and parsley, in hypoxia­induced apoptosis in rat dorsal root ganglion (DRG) neurons. It was observed that Myr significantly enhanced cell viability in hypoxia­induced DRG neurons in a dose­dependent manner; the optimal concentration of Myr was 50 µM. Furthermore, Myr reduced the percentage of deoxynucleotidyl transferase­mediated dUTP nick end­labeling­positive neuronal cells and influenced the expression of the pro­apoptotic gene B­cell lymphoma 2 (Bcl­2) associated X protein, the apoptosis protease cleaved caspase­3 and the anti­apoptotic gene Bcl­2, in the hypoxia­induced group. In addition, Myr protected against hypoxic injury in DRG neurons by inhibiting malondialdehyde and lactate dehydrogenase, however upregulating superoxide dismutase and glutathione peroxidase. Myr reduced the expression of endoplasmic reticulum stress (ERS) markers, including CCAAT/enhancer­binding protein­homologous protein, glucose­related protein 78 and cleaved caspase­12 in the hypoxia­induced group. To the best of our knowledge, this is the first demonstration of the activity of Myr against hypoxia­induced apoptosis in rat DRG neurons via inhibition of the ERS pathway.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Compostos de Benzil/farmacologia
Hipóxia Celular/efeitos dos fármacos
Dioxolanos/farmacologia
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Gânglios Espinais/citologia
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Pirogalol/análogos & derivados
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Gânglios Espinais/efeitos dos fármacos
Hipóxia/complicações
Hipóxia/tratamento farmacológico
Hipóxia/metabolismo
Masculino
Neurônios/citologia
Neurônios/metabolismo
Pirogalol/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzyl Compounds); 0 (Dioxolanes); 0 (Neuroprotective Agents); 01Y4A2QXY0 (Pyrogallol); 04PD6CT78W (myristicin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6258


  3 / 978 MEDLINE  
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[PMID]:28171692
[Au] Autor:Gaglio R; Barbera M; Aleo A; Lommatzsch I; La Mantia T; Settanni L
[Ad] Endereço:Dipartimento Scienze Agrarie e Forestali, Università degli Studi di Palermo, Viale delle Scienze 4, IT-90128, Palermo, Italy.
[Ti] Título:Inhibitory Activity and Chemical Characterization of Daucus carota subsp. maximus Essential Oils.
[So] Source:Chem Biodivers;14(5), 2017 May.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The essential oils (EOs) of green seeds from Daucus carota subsp. maximus growing wild in Pantelleria Island (Sicily, Italy) were characterized. EOs were extracted by steam distillation, examined for their inhibitory properties against food-borne Gram-positive and Gram-negative bacteria and analyzed for the chemical composition by gas chromatography (GC) and mass spectrometry (MS). Undiluted EOs showed a large inhibition spectrum against Gram-positive strains and also vs. Acinetobacter spp. and Stenotrophomonas maltophilia. The minimum inhibition concentration (MIC) was in the range 1.25 - 2.50 µl/ml for the most sensitive strains. The chemical analysis indicated that D. carota subsp. maximus EOs included 34 compounds (five monoterpene hydrocarbons, six oxygenated monoterpenes, 14 sesquiterpene hydrocarbons, four oxygenated sesquiterpenes, camphorene and four other compounds), accounting for 95.48% of the total oil, and that the major chemicals were carotol, ß-bisabolene, and isoelemicin.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Daucus carota/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Monoterpenos/análise
Pirogalol/análogos & derivados
Pirogalol/análise
Sementes/química
Sesquiterpenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (beta-bisabolene); 01Y4A2QXY0 (Pyrogallol); 487-12-7 (isoelemicin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600477


  4 / 978 MEDLINE  
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[PMID]:28153638
[Au] Autor:Kamae R; Nojima S; Akiyoshi K; Setsu S; Honda S; Masuda T; Oyama Y
[Ad] Endereço:Faculty of Integrated Arts and Sciences, Tokushima University, Tokushima 770-8502, Japan.
[Ti] Título:Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca concentration in rat thymic lymphocytes.
[So] Source:Food Chem Toxicol;102:39-45, 2017 Apr.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hydroxyhydroquinone (HHQ) is generated during coffee bean roasting. A cup of coffee contains 0.1-1.7 mg of HHQ. The actions of HHQ on mammalian DNA were examined because HHQ is a metabolite of benzene, which causes leukemia. Currently, information on the cellular actions of HHQ is limited. We examined the effects of sublethal levels of HHQ on the concentration of intracellular Ca in rat thymic lymphocytes by using a flow cytometric technique with fluorescent probes. HHQ at 10 µM or more significantly elevated intracellular Ca levels by increasing the membrane permeability of divalent cations, resulting in hyperpolarization via the activation of Ca -dependent K channels. HHQ-induced changes in the intracellular Ca concentration and membrane potential may affect the cell functions of lymphocytes. HHQ-reduced coffee may be preferable in order to avoid the possible adverse effects of HHQ.
[Mh] Termos MeSH primário: Cálcio/metabolismo
Coffea/química
Hidroquinonas/farmacologia
Linfócitos/efeitos dos fármacos
Timo/citologia
[Mh] Termos MeSH secundário: Animais
Morte Celular/efeitos dos fármacos
Células Cultivadas
Café
Citometria de Fluxo
Furanos/farmacologia
Linfócitos/citologia
Linfócitos/metabolismo
Fosfatidilserinas/metabolismo
Pirogalol/farmacologia
Ratos
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coffee); 0 (Furans); 0 (Hydroquinones); 0 (Phosphatidylserines); 01Y4A2QXY0 (Pyrogallol); 173O8B04RD (hydroxyhydroquinone); 3658-77-3 (furaneol); J41CSQ7QDS (Zinc); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE


  5 / 978 MEDLINE  
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[PMID]:28092983
[Au] Autor:Alizadeh A; Abdollahzadeh H
[Ad] Endereço:a Department of Medicinal and Aromatic Plants, Estahban Branch , Islamic Azad University , Estahban , Iran.
[Ti] Título:Essential oil constituents and antimicrobial activity of Pycnocycla bashagardiana Mozaff. from Iran.
[So] Source:Nat Prod Res;31(17):2081-2084, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pycnocycla bashagardiana is a rare endemic and endangered species that has been used in folkloric medicine in Southern Iran. This study aimed to evaluate the essential oil constituents and antimicrobial activity of wild and cultivated p. bashagardiana. The aerial parts of wild and cultivated plants were collected from two provinces of Iran. The essential oil was isolated by hydrodistillation and analyzed by a combination of capillary GC and GC-MS. The main components in wild plants were myristicin (39.12%), (E)-ß-ocimene (21.97%), sabinene (15.0%) and cis-iso-miristicin (2.67%) and in cultivated plants, (E)-ß-ocimene (55.40%), myristicin (18.27%), (Z)-ß-ocimene (12.47%) and cis-iso-miristicin (2.94%) were the main constituents in essential oil. The in vitro antimicrobial activity of the essential oil of P. bashagardiana were studied against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Candida albicans for the first time. The results showed that the oil exhibited strong antimicrobial activity against all the tested pathogens.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Apiaceae/química
Óleos Voláteis/química
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Alcenos/análise
Anti-Infecciosos/química
Compostos de Benzil/análise
Candida albicans/efeitos dos fármacos
Dioxolanos/análise
Avaliação Pré-Clínica de Medicamentos/métodos
Escherichia coli/efeitos dos fármacos
Cromatografia Gasosa-Espectrometria de Massas
Irã (Geográfico)
Testes de Sensibilidade Microbiana
Monoterpenos/análise
Plantas Medicinais/química
Pirogalol/análogos & derivados
Pirogalol/análise
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Anti-Infective Agents); 0 (Benzyl Compounds); 0 (Dioxolanes); 0 (Monoterpenes); 0 (Oils, Volatile); 01Y4A2QXY0 (Pyrogallol); 04PD6CT78W (myristicin); 13877-91-3 (beta-ocimene); 7D1TL44GPC (sabinene)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1274890


  6 / 978 MEDLINE  
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[PMID]:27896501
[Au] Autor:Baginski R; Sommerhalter M
[Ad] Endereço:Department of Chemistry and Biochemistry, California State University East Bay, Hayward, CA, 94542, USA.
[Ti] Título:A manganese catalase from Thermomicrobium roseum with peroxidase and catecholase activity.
[So] Source:Extremophiles;21(1):201-210, 2017 Jan.
[Is] ISSN:1433-4909
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:An enzyme with catechol oxidase activity was identified in Thermomicrobium roseum extracts via solution assays and activity-stained SDS-PAGE. Yet, the genome of T. roseum does not harbor a catecholase gene. The enzyme was purified with two anion exchange chromatography steps and ultimately identified to be a manganese catalase with additional peroxidase and catecholase activity. Catalase activity (6280 ± 430 IU/mg) clearly dominated over pyrogallol peroxidase (231 ± 53 IU/mg) and catecholase (3.07 ± 0.56 IU/mg) activity as determined at 70 °C. Most enzyme kinetic properties were comparable to previously characterized manganese catalase enzymes. Catalase activity was highest at alkaline pH values and showed inhibition by excess substrate and chloride. The apparent K and k values were 20 mM and 2.02 × 10 s subunit at 25 °C and pH 7.0.
[Mh] Termos MeSH primário: Proteínas de Bactérias/metabolismo
Catalase/metabolismo
Catecóis/metabolismo
Chloroflexi/enzimologia
Peroxidase/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Bactérias/química
Catalase/química
Estabilidade Enzimática
Temperatura Alta
Concentração de Íons de Hidrogênio
Peroxidase/química
Pirogalol/metabolismo
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Catechols); 01Y4A2QXY0 (Pyrogallol); EC 1.11.1.6 (Catalase); EC 1.11.1.7 (Peroxidase); LF3AJ089DQ (catechol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE
[do] DOI:10.1007/s00792-016-0896-9


  7 / 978 MEDLINE  
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[PMID]:27818046
[Au] Autor:Mohamed MA; Yehia AM; Banks CE; Allam NK
[Ad] Endereço:Pharmaceutical Chemistry Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.
[Ti] Título:Novel MWCNTs/graphene oxide/pyrogallol composite with enhanced sensitivity for biosensing applications.
[So] Source:Biosens Bioelectron;89(Pt 2):1034-1041, 2017 Mar 15.
[Is] ISSN:1873-4235
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel and highly sensitive biosensor employing graphene oxide nano-sheets (GO), multiwalled carbon nanotubes (MWCNTs), and pyrogallol (PG) was fabricated and utilized for the sensitive determination of omeprazole (OME). The morphological and structural features of the composite material were characterized using different techniques. The modified electrode showed a remarkable improvement in the anodic oxidation activity of OME due to the enhancement in the current response compared to the bare carbon paste electrode (CPE). Sensor composition and measurement conditions were optimized using an experimental design. Differential pulse voltammetry (DPVs) exhibited two expanded linear dynamic ranges of 2.0×10 -6.0×10 M and 6.0×10 -1.0×10 M for OME at pH 7 with a detection limit of 1.02×10 M. The practical analytical utilities of the modified electrode were demonstrated by the accurate determination of OME in pharmaceutical formulation and human serum samples with mean recoveries of 100.97% and 98.58%, respectively. The results clearly revealed that the proposed sensor is applicable to clinical analysis, quality control and routine determination of drugs in pharmaceutical formulations.
[Mh] Termos MeSH primário: Técnicas Biossensoriais
Técnicas Eletroquímicas
Omeprazol/isolamento & purificação
Pirogalol/química
[Mh] Termos MeSH secundário: Grafite/química
Seres Humanos
Limite de Detecção
Nanotubos de Carbono/química
Omeprazol/química
Óxidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon); 0 (Oxides); 01Y4A2QXY0 (Pyrogallol); 7782-42-5 (Graphite); KG60484QX9 (Omeprazole)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161108
[St] Status:MEDLINE


  8 / 978 MEDLINE  
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[PMID]:27769934
[Au] Autor:Szejk M; Poplawski T; Sarnik J; Pawlaczyk-Graja I; Czechowski F; Olejnik AK; Gancarz R; Zbikowska HM
[Ad] Endereço:Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
[Ti] Título:Polyphenolic glycoconjugates from medical plants of Rosaceae/Asteraceae family protect human lymphocytes against γ-radiation-induced damage.
[So] Source:Int J Biol Macromol;94(Pt A):585-593, 2017 Jan.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Radioprotective effects of the water-soluble polyphenolic glycoconjugates, isolated from flowers of Sanguisorba officinalis L.(SO) and Erigeron canadensis L.(EC), and from leaves of Fragaria vesca L. (FV) and Rubus plicatus Whe. Et N. E. (RP), against γ-radiation-induced toxicity in human peripheral blood lymphocytes were investigated. Cell treatment with glycoconjugates (1, 5 and 25µg/mL) prior exposure to 10/15Gy radiation resulted in concentration-dependent reduction of DNA damage including oxidative DNA lesions (comet assay), substantial inhibition of lipid peroxidation (TBARS) and restoration of superoxide dismutase and S-glutathione transferase activities. Glycoconjugates isolated from SO and EC ensured better protection versus these from RP and FV, with the SO product potential comparable to that of the reference quercetin. Strong antioxidant/radioprotective activity of the SO and EC glycoconjugates could be attributed to high abundance of syringol-type and ferulic acid units in their matrices, respectively. Moreover, polyphenolic glycoconjugates (25µg/mL), including RP and FV products, significantly decreased DNA damage when applied post-radiation suggesting their modulating effects on DNA repair pathways. Preliminary data on the glycoconjugate phenolic structural units, based on GLC/MS of the products of pyrolysis and in situ methylation, in relation to application of plant products as potential radioprotectors is promising and deserves further investigation.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Asteraceae/química
Glicoconjugados/farmacologia
Leucócitos Mononucleares/efeitos dos fármacos
Protetores contra Radiação/farmacologia
Rosaceae/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Ensaio Cometa
Ácidos Cumáricos/análise
Ácidos Cumáricos/química
Fragmentação do DNA/efeitos dos fármacos
Fragmentação do DNA/efeitos da radiação
Reparo do DNA/efeitos dos fármacos
Reparo do DNA/efeitos da radiação
Raios gama
Glutationa Transferase/metabolismo
Glicoconjugados/química
Glicoconjugados/isolamento & purificação
Seres Humanos
Leucócitos Mononucleares/citologia
Leucócitos Mononucleares/metabolismo
Leucócitos Mononucleares/efeitos da radiação
Extratos Vegetais/química
Cultura Primária de Células
Pirogalol/análogos & derivados
Pirogalol/análise
Pirogalol/química
Quercetina/farmacologia
Protetores contra Radiação/química
Protetores contra Radiação/isolamento & purificação
Superóxido Dismutase/metabolismo
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Coumaric Acids); 0 (Glycoconjugates); 0 (Plant Extracts); 0 (Radiation-Protective Agents); 0 (Thiobarbituric Acid Reactive Substances); 01Y4A2QXY0 (Pyrogallol); 4UQT464H8K (pyrogallol 1,3-dimethyl ether); 9IKM0I5T1E (Quercetin); AVM951ZWST (ferulic acid); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE


  9 / 978 MEDLINE  
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[PMID]:27334372
[Au] Autor:Al-Malahmeh AJ; Al-Ajlouni A; Wesseling S; Soffers AE; Al-Subeihi A; Kiwamoto R; Vervoort J; Rietjens IM
[Ad] Endereço:Division of Toxicology, Wageningen University, Building 124, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. amer.almalahmeh@wur.nl.
[Ti] Título:Physiologically based kinetic modeling of the bioactivation of myristicin.
[So] Source:Arch Toxicol;91(2):713-734, 2017 Feb.
[Is] ISSN:1432-0738
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present study describes physiologically based kinetic (PBK) models for the alkenylbenzene myristicin that were developed by extension of the PBK models for the structurally related alkenylbenzene safrole in rat and human. The newly developed myristicin models revealed that the formation of the proximate carcinogenic metabolite 1'-hydroxymyristicin in liver is at most 1.8 fold higher in rat than in human and limited for the ultimate carcinogenic metabolite 1'-sulfoxymyristicin to (2.8-4.0)-fold higher in human. In addition, a comparison was made between the relative importance of bioactivation for myristicin and safrole. Model predictions indicate that for these related compounds, the formation of the 1'-sulfoxy metabolites in rat and human liver is comparable with a difference of <2.2-fold over a wide dose range. The results from this PBK analysis support that risk assessment of myristicin may be based on the BMDL derived for safrole of 1.9-5.1 mg/kg bw per day. Using an estimated daily intake of myristicin of 0.0019 mg/kg bw per day resulting from the use of herbs and spices, this results in MOE values for myristicin that amount to 1000-2700, indicating a priority for risk management. The results obtained illustrate that PBK modeling provides insight into possible species differences in the metabolic activation of myristicin. Moreover, they provide an example of how PBK modeling can facilitate a read-across in risk assessment from a compound for which in vivo toxicity studies are available to a related compound for which tumor data are not reported, thus contributing to alternatives in animal testing.
[Mh] Termos MeSH primário: Compostos de Benzil/farmacocinética
Dioxolanos/farmacocinética
Modelos Teóricos
Pirogalol/análogos & derivados
[Mh] Termos MeSH secundário: Ativação Metabólica
Animais
Carcinógenos/farmacocinética
Seres Humanos
Inativação Metabólica
Cinética
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Microssomos/efeitos dos fármacos
Microssomos/metabolismo
Oxirredução
Pirogalol/farmacocinética
Ratos Sprague-Dawley
Medição de Risco/métodos
Safrol/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1'-sulfoxymyristicin); 0 (Benzyl Compounds); 0 (Carcinogens); 0 (Dioxolanes); 01Y4A2QXY0 (Pyrogallol); 04PD6CT78W (myristicin); RSB34337V9 (Safrole)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1007/s00204-016-1752-5


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[PMID]:27328858
[Au] Autor:Han Y; Wang L
[Ad] Endereço:Key Laboratory of Bio-based Materials Science and Technology of Ministry of Education, Northeast Forestry University, 26 Hexing Road, Harbin 150040, PR China.
[Ti] Título:Sodium alginate/carboxymethyl cellulose films containing pyrogallic acid: physical and antibacterial properties.
[So] Source:J Sci Food Agric;97(4):1295-1301, 2017 Mar.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antibacterial films were prepared using sodium alginate (SA) and carboxymethyl cellulose (CMC) as a matrix, glycerin as a plasticizer and CaCl as a cross-linking agent, and by incorporating the natural antibacterial agent pyrogallic acid (PA). The present study describes the microstructure and the physical, barrier, mechanical, optical and antibacterial properties of blended films prepared by incorporating different concentrations of PA into the SA/CMC matrix. RESULTS: The microstructure of the films was investigated by Fourier transform infrared spectroscopy and scanning electron microscopy, which revealed that PA interacts with the SA/CMC matrix through hydrogen bonding. Moreover, the incorporation of PA increased the moisture content, water vapor permeability and oxygen permeability of SA/CMC films. Films containing 40 g kg of PA had the highest elongation at break result (39.60%). Compared with pure SA/CMC films, the incorporation of PA improved the barrier properties against ultraviolet light; however, it decreased the color parameter L* value and increased the a* and b* values of the films. Furthermore, films with PA, especially at higher concentrations, were more effective against Escherichia coli and Staphylococcus aureus. CONCLUSION: Antibacterial SA/CMC films incorporating PA appear to have good potential to enhance the safety of foods and food products. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Alginatos
Antibacterianos
Plásticos Biodegradáveis/química
Carboximetilcelulose Sódica
Microbiologia de Alimentos
Embalagem de Alimentos/métodos
Pirogalol
[Mh] Termos MeSH secundário: Cloreto de Cálcio
Cor
Elasticidade
Escherichia coli/crescimento & desenvolvimento
Ácido Glucurônico
Glicerol
Ácidos Hexurônicos
Seres Humanos
Ligações de Hidrogênio
Oxigênio
Permeabilidade
Plastificantes
Staphylococcus aureus/crescimento & desenvolvimento
Raios Ultravioleta
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alginates); 0 (Anti-Bacterial Agents); 0 (Biodegradable Plastics); 0 (Hexuronic Acids); 0 (Plasticizers); 01Y4A2QXY0 (Pyrogallol); 059QF0KO0R (Water); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); K679OBS311 (Carboxymethylcellulose Sodium); M4I0D6VV5M (Calcium Chloride); PDC6A3C0OX (Glycerol); S88TT14065 (Oxygen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160623
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.7863



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