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[PMID]:29017816
[Au] Autor:Chang J; Wang H; Xu P; Guo B; Li J; Wang Y; Li W
[Ad] Endereço:Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing, 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing, 100049, China.
[Ti] Título:Oral and dermal diflubenzuron exposure causes a hypothalamic-pituitary-thyroid (HPT) axis disturbance in the Mongolian racerunner (Eremias argus).
[So] Source:Environ Pollut;232:338-346, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Diflubenzuron (DFB) is a potential endocrine-disrupting chemical. However, its thyroid endocrine effect on reptiles has not been reported. In this study, immature lizards (Eremias argus) were exposed to 20 mg kg DFB once a week for 42 days through oral or dermal routes. Their body weight, plasma thyroid hormone levels, thyroid gland histology and the transcription of hypothalamic-pituitary-thyroid (HPT) axis-related genes in different tissues were assessed to explore the effects of DFB on the HPT axis of lizards. The body weight decreased significantly only after the dermal exposure to DFB. Triiodothyronine (T3) to thyroxine (T4) ratio in the male plasma also significantly increased after the dermal exposure. After oral exposure, the activity of thyroid gland was positively related to the thyroid hormone levels. Furthermore, the alterations in thyroid hormone levels affected the HPT axis-related gene expression, which was tissue dependent and sexually selected. The thyroid hormone receptor genes (trα and trß) in the brain and thyroid were more sensitive to oral exposure. However, only the dermal treatment affected the trα, trß and type 2 deiodinase (dio2) genes in the male liver. These results suggest that DFB exposure caused sex-specific changes in the thyroid function of lizards, and the dermal treatment may be an important route for the risk assessment of reptiles.
[Mh] Termos MeSH primário: Diflubenzuron/toxicidade
Disruptores Endócrinos/toxicidade
Hormônios Juvenis/toxicidade
Lagartos/fisiologia
[Mh] Termos MeSH secundário: Animais
Disruptores Endócrinos/metabolismo
Hipotálamo/efeitos dos fármacos
Lagartos/metabolismo
Masculino
Hipófise/efeitos dos fármacos
Glândula Tireoide/metabolismo
Hormônios Tireóideos/metabolismo
Tiroxina/sangue
Testes de Toxicidade
Tri-Iodotironina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Juvenile Hormones); 0 (Thyroid Hormones); 06LU7C9H1V (Triiodothyronine); J76U6ZSI8D (Diflubenzuron); Q51BO43MG4 (Thyroxine)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE


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[PMID]:28876214
[Au] Autor:Bechmann RK; Lyng E; Berry M; Kringstad A; Westerlund S
[Ad] Endereço:a International Research Institute of Stavanger (IRIS) , Randaberg , Norway.
[Ti] Título:Exposing Northern shrimp (Pandalus borealis) to fish feed containing the antiparasitic drug diflubenzuron caused high mortality during molting.
[So] Source:J Toxicol Environ Health A;80(16-18):941-953, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Use of the chitin synthesis inhibitor diflubenzuron (DFB) as an antiparasitic drug in salmon aquaculture raises concern over its impact on marine ecosystems. Further, global drivers, such as ocean warming and acidification (OAW), may increase the toxicity of hazardous substances including DFB. The aim of the present study was to examine the combined effects of DFB-medicated salmon feed on ovigerous Northern shrimp (Pandalus borealis) under Control (pH 8.0, 7.0ºC) and OAW conditions (pH 7.6, 9.5ºC). DFB-exposed shrimp consumed on average 0.1-0.3 g medicated feed during the 2-week exposure period, and high mortality (61-73%) was documented at both environmental conditions. There was no significant interaction between OAW and DFB. Only 2-7% of DFB-exposed shrimp molted successfully compared to 65% in Control and 63% in OAW. The shrimp molted earlier (shorter intermolt period) and exhibited higher feeding rate at OAW compared to Control conditions. An additional experiment, where female shrimp were exposed to DFB closer to molting, noted increased mortality after only 4 d exposure, and successful molting for some shrimp after 2 to 3 weeks of depuration. High mortality of shrimp exposed to DFB-medicated feed indicates that the use of this feed in aquaculture could affect local shrimp populations.
[Mh] Termos MeSH primário: Antiparasitários/toxicidade
Diflubenzuron/toxicidade
Muda/efeitos dos fármacos
Pandalidae/efeitos dos fármacos
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Dieta/veterinária
Relação Dose-Resposta a Droga
Feminino
Peixes
Pandalidae/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); J76U6ZSI8D (Diflubenzuron)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1352213


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[PMID]:28511076
[Au] Autor:Chang J; Li W; Xu P; Guo B; Wang Y; Li J; Wang H
[Ad] Endereço:Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing 100049, China.
[Ti] Título:The tissue distribution, metabolism and hepatotoxicity of benzoylurea pesticides in male Eremias argus after a single oral administration.
[So] Source:Chemosphere;183:1-8, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Benzoylurea pesticides (BPUs) are widely used to control the locust, but the toxicokinetics and hepatotoxicity of BPUs in lizards have not been investigated. In this study, the tissue distribution, metabolism and liver toxicity of diflubenzuron and flufenoxuron were assessed in the Eremias argus following a single oral exposure. Diflubenzuron preferred to accumulate in the fat and brain (>1.0 mg kg ) and was rapidly eliminate in other tissues. In the liver, 4-chloroaniline was one of diflubenzuron metabolites, although with a concentration less than 0.05% of the accumulated diflubenzuron. No significant difference was observed in the liver histopathology between the control and diflubenzuron exposure group. The expressions of Cyp1a and Ahr gene which control the cell apoptosis were also equal to the control level. After flufenoxuron exposure, biomodal phenomenon was observed in the liver, skin, brain, gonad, kidney, heart and blood circulation was an important route for the flufenoxuron penetration. The concentrations of flufenoxuron in all tissues were greater than 1.0 mg kg at 168 h. The excretion of flufenoxuron in the faeces was 1.5 fold higher than diflubenzuron. The hepatocytes in the flufenoxuron treated group showed vacuolation of cytoplasm and decreased nucleus. In addition, the Cyp1a and Ahr genes were significantly up-regulated in the flufenoxuron exposure group. These results suggested that the higher hepatotoxicity of flufenoxuron may be attributed to the higher residual level in the lizard tissues and the Cyp1a and Ahr genes can serve as biomarkers to assess the liver toxicity.
[Mh] Termos MeSH primário: Diflubenzuron/toxicidade
Poluentes Ambientais/toxicidade
Fígado/efeitos dos fármacos
Lagartos/metabolismo
Praguicidas/toxicidade
Compostos de Fenilureia/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Compostos de Anilina/metabolismo
Animais
Diflubenzuron/metabolismo
Monitoramento Ambiental
Poluentes Ambientais/metabolismo
Fezes/química
Hepatócitos/efeitos dos fármacos
Hepatócitos/metabolismo
Fígado/metabolismo
Masculino
Taxa de Depuração Metabólica
Praguicidas/metabolismo
Compostos de Fenilureia/metabolismo
Distribuição Tecidual
Toxicocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aniline Compounds); 0 (Environmental Pollutants); 0 (Pesticides); 0 (Phenylurea Compounds); J76U6ZSI8D (Diflubenzuron); OD068OSS0N (flufenoxuron); Z553SGH315 (4-chloroaniline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170927
[Lr] Data última revisão:
170927
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE


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[PMID]:28161465
[Au] Autor:Anacleto P; van den Heuvel FHM; Oliveira C; Rasmussen RR; Fernandes JO; Sloth JJ; Barbosa V; Alves RN; Marques A; Cunha SC
[Ad] Endereço:Portuguese Institute for the Sea and Atmosphere, I.P. (IPMA), Division of Aquaculture and Upgrading (DivAV), Avenida de Brasília, 1449-006 Lisboa, Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Rua dos Bragas, 289, 4050-123 Porto, Portugal; MAR
[Ti] Título:Exploration of the phycoremediation potential of Laminaria digitata towards diflubenzuron, lindane, copper and cadmium in a multitrophic pilot-scale experiment.
[So] Source:Food Chem Toxicol;104:95-108, 2017 Jun.
[Is] ISSN:1873-6351
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The presence of contaminants in aquatic ecosystems can cause serious problems to the environment and marine organisms. This study aims to evaluate the phycoremediation capacity of macroalgae Laminaria digitata for pesticides (diflubenzuron and lindane) and toxic elements (cadmium and copper) in seawater in the presence or absence of mussels. The photosynthetic activity was monitored in the macroalgae to assess its "physiological status". The results showed that the presence of algae decreased diflubenzuron concentration in mussels by 70% after 120 h of exposure. Additionally, this macroalgae was efficient to reduce lindane, Cu and Cd in seawater; even though it not was able to reduce these contaminants in mussels. The studied pollutants did not affect the physiological status of macroalgae. This study reveals that the application of phycoremediation with macroalgae can be an useful and effective mitigation strategy to remove/decrease contaminant levels from the aquatic environment.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Cobre/metabolismo
Diflubenzuron/metabolismo
Recuperação e Remediação Ambiental/métodos
Laminaria/metabolismo
Lindano/metabolismo
Alga Marinha/metabolismo
Poluentes Químicos da Água/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Cádmio/análise
Cobre/análise
Diflubenzuron/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 00BH33GNGH (Cadmium); 59NEE7PCAB (Lindane); 789U1901C5 (Copper); J76U6ZSI8D (Diflubenzuron)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


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[PMID]:28116643
[Au] Autor:Chen XD; Gill TA; Pelz-Stelinski KS; Stelinski LL
[Ad] Endereço:Entomology and Nematology Department, University of Florida, Citrus Research and Education Center, 700 Experiment Station Rd, Lake Alfred, FL, 33850, USA. xuedongchen@ymail.com.
[Ti] Título:Risk assessment of various insecticides used for management of Asian citrus psyllid, Diaphorina citri in Florida citrus, against honey bee, Apis mellifera.
[So] Source:Ecotoxicology;26(3):351-359, 2017 Apr.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae), is a major pest of citrus trees worldwide. A wide variety of insecticides are used to manage D. citri populations within citrus groves in Florida. However, in areas shared by citrus growers and beekeepers the use of insecticides may increase the risks of Apis mellifera  L. (Hymenoptera: Apidae) loss and contaminated honey. The objective of this research was to determine the environmental toxicity of insecticides, spanning five different modes of action used to control D. citri, to A. mellifera. The insecticides investigated were imidacloprid, fenpropathrin, dimethoate, spinetoram and diflubenzuron. In laboratory experiments, LD values were determined and ranged from 0.10 to 0.53 ng/µl for imidacloprid, fenpropathrin, dimethoate and spinetoram. LD values for diflubenzuron were >1000 ng/µl. Also, a hazard quotient was determined and ranged from 1130.43 to 10893.27 for imidacloprid, fenpropathrin, dimethoate, and spinetoram. This quotient was <0.447 for diflubenzuron. In field experiments, residual activity of fenpropathrin and dimethoate applied to citrus caused significant mortality of A. mellifera 3 and 7 days after application. Spinetoram and imidacloprid were moderately toxic to A. mellifera at the recommended rates for D. citri. Diflubenzuron was not toxic to A. mellifera in the field as compared with untreated control plots. Phenoloxidase (PO) activity of A. mellifera was higher than in untreated controls when A. mellifera were exposed to 14 days old residues. The results indicate that diflubenzuron may be safe to apply in citrus when A. mellifera are foraging, while most insecticides used for management of D. citri in citrus are likely hazardous under various exposure scenarios.
[Mh] Termos MeSH primário: Abelhas/fisiologia
Hemípteros/fisiologia
Controle de Insetos/métodos
Inseticidas/toxicidade
[Mh] Termos MeSH secundário: Animais
Citrus
Diflubenzuron/toxicidade
Dimetoato/toxicidade
Ecotoxicologia
Imidazóis/toxicidade
Macrolídeos/toxicidade
Neonicotinoides
Nitrocompostos/toxicidade
Piretrinas/toxicidade
Medição de Risco
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Imidazoles); 0 (Insecticides); 0 (Macrolides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (Pyrethrins); 3BN7M937V8 (imidacloprid); 87BH96P0MX (fenpropathrin); J76U6ZSI8D (Diflubenzuron); W6U08B045O (Dimethoate); YGZ1037ELN (spinetoram)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-017-1768-5


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[PMID]:28017929
[Au] Autor:Guo W; Yan X; Zhao G; Han R
[Ad] Endereço:South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
[Ti] Título:Increased Efficacy of Entomopathogenic Nematode-Insecticide Combinations Against Holotrichia oblita (Coleoptera: Scarabaeidae).
[So] Source:J Econ Entomol;110(1):41-51, 2017 02 01.
[Is] ISSN:1938-291X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Combinations of entomopathogenic nematodes Steinernema longicaudum X-7 and Heterorhabditis bacteriophora H06 with chlorantraniliprole, diflubenzuron, and imidacloprid insecticides at different rates for the control of the white grub, Holotrichia oblita Faldermann (Coleoptera: Scarabaeidae), were evaluated both in the laboratory and in peanut fields. In the laboratory, the combinations had a synergistic or additive effect on the second-instar larvae of H. oblita and caused faster mortality than one nematode species or insecticide alone. Heterorhabditis bacteriophora-chlorantraniliprole and H. bacteriophora-imidacloprid showed synergistic effects on the larvae. When higher concentrations of the insecticides were combined with nematodes, the stronger synergistic effects were found. In peanut fields, S. longicaudum-imidacloprid, H. bacteriophora-imidacloprid, or H. bacteriophora-chlorantraniliprole also showed synergistic effects against the larvae. The three nematode-insecticide combinations produced similar percentage reductions of the grub larvae and less percentages of injured legumes, compared with the chlorpyrifos treatment. Cost-benefit analysis showed that H. bacteriophora 5.0 × 103 infective juveniles (IJs) per plant (equal to 7.5 × 108 IJ ha-1) combined with imidacloprid at the recommended concentration is a practical strategy for the practitioner to manage the white grubs in the peanut production.
[Mh] Termos MeSH primário: Coleópteros
Controle de Insetos
Inseticidas
Controle Biológico de Vetores
Rabditídios/fisiologia
[Mh] Termos MeSH secundário: Animais
Arachis/crescimento & desenvolvimento
Coleópteros/crescimento & desenvolvimento
Coleópteros/parasitologia
Análise Custo-Benefício
Diflubenzuron
Relação Dose-Resposta a Droga
Interações Hospedeiro-Parasita
Imidazóis
Larva/crescimento & desenvolvimento
Larva/parasitologia
Neonicotinoides
Nitrocompostos
ortoaminobenzoatos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Imidazoles); 0 (Insecticides); 0 (Neonicotinoids); 0 (Nitro Compounds); 0 (ortho-Aminobenzoates); 3BN7M937V8 (imidacloprid); 622AK9DH9G (chlorantranilipole); J76U6ZSI8D (Diflubenzuron)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161227
[St] Status:MEDLINE
[do] DOI:10.1093/jee/tow241


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[PMID]:27894725
[Au] Autor:Tucca F; Moya H; Pozo K; Borghini F; Focardi S; Barra R
[Ad] Endereço:Facultad de Ciencias Ambientales y Centro EULA-Chile, Universidad de Concepción, Barrio Universitario s/n, P.O. Box 160-C, Concepción, Chile. Electronic address: ftuca@udec.cl.
[Ti] Título:Occurrence of antiparasitic pesticides in sediments near salmon farms in the northern Chilean Patagonia.
[So] Source:Mar Pollut Bull;115(1-2):465-468, 2017 Feb 15.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Growth of the aquaculture industry has triggered the need for research into the potential environmental impact of chemicals used by salmon farms to control diseases. In this study, the antiparasitic pesticides emamectin benzoate (EB), diflubenzuron (DI), teflubenzuron (TE), and cypermethrin (CP) were measured in sediments near salmon cages in southern Chile. Concentrations for EB were between 2.2 and 14.6ngg , while the benzoylphenyl ureas DI and TE were detected in the ranges of 0.1 to 1.2ngg and 0.8 to 123.3ngg , respectively. These results were similar to data reported for the Northern Hemisphere. On the other hand, the pyrethroid CP was detected in higher concentrations, ranging from 18.0 to 1323.7ngg . According to reported toxicity data, this range represents a potential risk for benthic invertebrates. This report is the first baseline attempt at assessing antiparasitic pesticide levels in the Chilean Patagonia.
[Mh] Termos MeSH primário: Antiparasitários/análise
Aquicultura
Sedimentos Geológicos/química
Salmão
[Mh] Termos MeSH secundário: Animais
Benzamidas/análise
Chile
Diflubenzuron/análise
Ivermectina/análogos & derivados
Ivermectina/análise
Praguicidas/análise
Piretrinas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 0 (Benzamides); 0 (Pesticides); 0 (Pyrethrins); 1TR49121NP (cypermethrin); 70288-86-7 (Ivermectin); FS9P57VL74 (teflubenzuron); HVM3G4A01W (emamectin benzoate); J76U6ZSI8D (Diflubenzuron)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161130
[St] Status:MEDLINE


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[PMID]:27728890
[Au] Autor:Khan HAA; Akram W
[Ad] Endereço:Institute of Agricultural Sciences, University of the Punjab, Lahore, Pakistan. Electronic address: azhar_naturalist@yahoo.com.
[Ti] Título:Cyromazine resistance in a field strain of house flies, Musca domestica L.: Resistance risk assessment and bio-chemical mechanism.
[So] Source:Chemosphere;167:308-313, 2017 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Developing resistance management strategies for eco-friendly insecticides is essential for the management of insect pests without harming the environment. Cyromazine is a biorational insecticide with very low mammalian toxicity. Resistance to cyromazine has recently been reported in house flies from Punjab, Pakistan. In order to propose a resistance management strategy for cyromazine, experiments were planned to study risk for resistance development, possibility of cross-resistance and bio-chemical mechanisms. A field strain of house flies with 8.78 fold resistance ratio (RR) to cyromazine was re-selected under laboratory conditions. After seven rounds of selection (G1-G7), the RR values rapidly increased from 8.8 to 211 fold. However, these values declined to 81fold when the cyromazine selected (CYR-SEL) strain was reared without selection pressure, suggesting an unstable nature of resistance. The CYR-SEL strain showed lack of cross-resistance to pyriproxyfen, diflubenzuron, and methoxyfenozide. Synergism bioassays using enzyme inhibitors: piperonyl butoxide (PBO) and S,S,S-tributylphosphorotrithioate (DEF), and metabolic enzyme analyses revealed increased activity of carboxylesterase (CarE) and mixed-function oxidase (MFO) in the CYR-SEL strain compared to the laboratory susceptible (Lab-susceptible) strain, suggesting the metabolic resistance mechanism responsible for cyromazine resistance in the CYR-SEL strain. In conclusion, risk of rapid development of cyromazine resistance under consistent selection pressure discourages the sole reliance on cyromazine for controlling house flies in the field. The unstable nature of cyromazine resistance provides window for restoring cyromazine susceptibility by uplifting selection pressure in the field. Moreover, lack of cross-resistance between cyromazine and pyriproxyfen, diflubenzuron, or methoxyfenozide in the CYR-SEL strain suggest that cyromazine could be rotated with these insecticides whenever resistance crisis occur in the field.
[Mh] Termos MeSH primário: Moscas Domésticas/efeitos dos fármacos
Resistência a Inseticidas
Inseticidas/toxicidade
Triazinas/toxicidade
[Mh] Termos MeSH secundário: Animais
Diflubenzuron/toxicidade
Relação Dose-Resposta a Droga
Sinergismo Farmacológico
Inibidores Enzimáticos/farmacologia
Moscas Domésticas/enzimologia
Hidrazinas/toxicidade
Resistência a Inseticidas/efeitos dos fármacos
Hormônios Juvenis/toxicidade
Dose Letal Mediana
Modelos Teóricos
Paquistão
Butóxido de Piperonila/toxicidade
Piridinas/toxicidade
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Hydrazines); 0 (Insecticides); 0 (Juvenile Hormones); 0 (Pyridines); 0 (Triazines); 3Q9VOR705O (pyriproxyfen); 62A22651ZX (methoxyfenozide); CA49Y29RA9 (cyromazine); J76U6ZSI8D (Diflubenzuron); LWK91TU9AH (Piperonyl Butoxide)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27509597
[Au] Autor:World Health Organization
[Ti] Título:Evaluation of certain veterinary drug residues in food. Eighty-first report of the Joint FAO/WHO Expert Committee on Food Additives.
[So] Source:World Health Organ Tech Rep Ser;(997):1-110, 2016.
[Is] ISSN:0512-3054
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including MRLs for generic fish species, acute reference doses (ARfDs) for veterinary drugs, an approach for dietary exposure assessment of compounds used for multiple purposes (i.e veterinary drugs and pesticides), dietary exposure assessment for less-than-lifetime exposure, and the assessment of short-term (90-day and 12-month) studies in dogs. Summaries follow of the Committee's evaluations of toxicological and residue data on a variety of veterinary drugs: two insecticides (diflubenzuron and teflubenzuron), an antiparasitic agent (ivermectin), an ectoparasiticide (sisapronil) and a ß2-adrenoceptor agonist (zilpaterol hydrochloride). In addition, the Committee considered issues raised in concern forms from the Codex Committee on Residues of Veterinary Drugs in Foods on lasalocid sodium, an antiparasitic agent. Annexed to the report is a summary of the Committee's recommendations on these drugs, including acceptable daily intakes (ADIs), ARfDs and proposed MRLs.
[Mh] Termos MeSH primário: Resíduos de Drogas/análise
Contaminação de Alimentos/análise
Drogas Veterinárias/análise
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos
Antiparasitários
Benzamidas
Dieta
Diflubenzuron
Cães
Resíduos de Drogas/toxicidade
Peixes
Inocuidade dos Alimentos
Seres Humanos
Hidrocarbonetos Halogenados
Inseticidas
Ivermectina
Lasalocida
Concentração Máxima Permitida
Resíduos de Praguicidas/análise
Pirazóis
Compostos de Trimetilsilil
Drogas Veterinárias/toxicidade
Organização Mundial da Saúde
[Pt] Tipo de publicação:JOURNAL ARTICLE; TECHNICAL REPORT
[Nm] Nome de substância:
0 (5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(2,2-difluoro-1-(trifluoromethyl)cyclopropyl)pyrazole-3-carbonitrile); 0 (Anthelmintics); 0 (Antiparasitic Agents); 0 (Benzamides); 0 (Hydrocarbons, Halogenated); 0 (Insecticides); 0 (Pesticide Residues); 0 (Pyrazoles); 0 (Trimethylsilyl Compounds); 0 (Veterinary Drugs); 0 (Zilpaterol); 70288-86-7 (Ivermectin); FS9P57VL74 (teflubenzuron); J76U6ZSI8D (Diflubenzuron); W7V2ZZ2FWB (Lasalocid)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE


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[PMID]:27501778
[Au] Autor:da Silva GN; Trindade FT; Dos Santos F; Gosmann G; E Silva AA; Gnoatto SC
[Ad] Endereço:Phytochemistry and Organic Synthesis Laboratory, School of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
[Ti] Título:Larvicidal activity of natural and modified triterpenoids against Aedes aegypti (Diptera: Culicidae).
[So] Source:Pest Manag Sci;72(10):1883-7, 2016 Oct.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Insecticide resistance to commonly used substances demands new molecules for the chemical control of the dengue vector Aedes aegypti. Because natural product sources have been an alternative to obtain larvicidal compounds, the aim of this study was to evaluate the triterpenoids betulinic (BA) and ursolic (UA) acids and their semi-synthetic derivatives against larval Ae. aegypti. BA, UA, ten derivatives modified at the C-3 position and a positive control (diflubenzuron) were evaluated. Larvicidal assays were carried out with early fourth-instar larvae, and mortality was observed between 48 and 96 h. Doses from 200 to 10 ppm were used to calculate lethal concentrations (LCs). RESULTS: Natural compounds, i.e. UA and BA, had the lowest LCs (LC50 of 112 and 142 ppm respectively), except for the modified compound 2b (LC50 of 130 ppm). Larvicidal activity increased significantly from 48 to 96 h for all the compounds evaluated, ranging from 20 to 50% after 48 h and from 48 to 76% after 96 h. Some derivatives, e.g. 2a and 2d, had up to a three-fold larvicidal activity increase from 48 to 96 h. CONCLUSION: BA, UA and their derivatives showed larvicidal activity against Ae. aegypti larvae, increasing significantly from 48 to 96 h. The presence of a hydroxyl group is essential for larvicidal potential in these triterpenoids. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Aedes
Inseticidas
Triterpenos
[Mh] Termos MeSH secundário: Animais
Dengue
Diflubenzuron
Insetos Vetores
Larva
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Triterpenes); 4G6A18707N (betulinic acid); J76U6ZSI8D (Diflubenzuron); P3M2575F3F (ursolic acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4221



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