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Referências encontradas : 373 [refinar]
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  1 / 373 MEDLINE  
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[PMID]:28951608
[Au] Autor:Wang L; Li M; Tang J; Lin Y; Sidthipong K; Sumida N; Kushida N; Umezawa K
[Ad] Endereço:College of Life Sciences and Oceanography, Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, Shenzhen University, Shenzhen, PR China.
[Ti] Título:Novel p-terphenyl glycoside with a rare 2,6-dideoxyhexopyranose moiety from Actinomycete strain SF2911 that inhibits cancer cell migration.
[So] Source:J Antibiot (Tokyo);70(10):987-990, 2017 Oct.
[Is] ISSN:0021-8820
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:In the course of our search for inhibitors of LPS-induced NO production from microbial strains, an ethyl acetate extract of Actinomycete SF2911, isolated from a soil sample collected in Okinawa Prefecture, Japan, showed the inhibitory activity. The active principle was purified and structure determination led to the isolation of one new compound. Since the structure belongs to the terfestatin family, we named it terfestatin D (1). It was found to inhibit cellular migration of breast carcinoma cells as well as NO production. We herein report the isolation, structure elucidation and biological activities of this new compound.
[Mh] Termos MeSH primário: Actinobacteria/química
Antineoplásicos/farmacologia
Produtos Biológicos/farmacologia
Movimento Celular/efeitos dos fármacos
Compostos de Terfenil/farmacologia
[Mh] Termos MeSH secundário: Actinobacteria/classificação
Actinobacteria/isolamento & purificação
Animais
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Produtos Biológicos/química
Produtos Biológicos/isolamento & purificação
Linhagem Celular Tumoral
Células Epiteliais/efeitos dos fármacos
Feminino
Seres Humanos
Japão
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Óxido Nítrico/antagonistas & inibidores
Células RAW 264.7
Microbiologia do Solo
Compostos de Terfenil/química
Compostos de Terfenil/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biological Products); 0 (Terphenyl Compounds); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1038/ja.2017.83


  2 / 373 MEDLINE  
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[PMID]:28936880
[Au] Autor:Granchi C; Caligiuri I; Bertelli E; Poli G; Rizzolio F; Macchia M; Martinelli A; Minutolo F; Tuccinardi T
[Ad] Endereço:a Department of Pharmacy , University of Pisa , Pisa , Italy.
[Ti] Título:Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors.
[So] Source:J Enzyme Inhib Med Chem;32(1):1240-1252, 2017 Dec.
[Is] ISSN:1475-6374
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors are reported in literature; however, many of them are characterised by an irreversible mechanism of action and this behavior determines an unwanted chronic MAGL inactivation, which acquires a functional antagonism of the endocannabinoid system. The possible use of reversible MAGL inhibitors has only recently been explored, due to the lack of known compounds possessing efficient reversible inhibitory activities. In this work, we report a new series of terphenyl-2-methyloxazol-5(4H)-one derivatives characterised by a reversible MAGL-inhibition mechanism. Among them, compound 20b showed to be a potent MAGL reversible inhibitor (IC = 348 nM) with a good MAGL/FAAH selectivity. Furthermore, this compound showed antiproliferative activities against two different cancer cell lines that overexpress MAGL.
[Mh] Termos MeSH primário: Monoacilglicerol Lipases/antagonistas & inibidores
Oxazóis/farmacologia
Compostos de Terfenil/farmacologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Seres Humanos
Estrutura Molecular
Monoacilglicerol Lipases/metabolismo
Oxazóis/síntese química
Oxazóis/química
Proteínas Recombinantes/metabolismo
Relação Estrutura-Atividade
Compostos de Terfenil/síntese química
Compostos de Terfenil/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-((4,4'-dimethoxy-(1,1':4',1'-terphenyl)-2'-yl)methylene)-2-methyloxazol-5(4H)-one); 0 (Oxazoles); 0 (Recombinant Proteins); 0 (Terphenyl Compounds); EC 3.1.1.23 (Monoacylglycerol Lipases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1080/14756366.2017.1375484


  3 / 373 MEDLINE  
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[PMID]:28384525
[Au] Autor:Intaraudom C; Bunbamrung N; Dramae A; Boonyuen N; Kongsaeree P; Srichomthong K; Supothina S; Pittayakhajonwut P
[Ad] Endereço:National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Paholyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
[Ti] Título:Terphenyl derivatives and drimane - Phathalide/isoindolinones from Hypoxylon fendleri BCC32408.
[So] Source:Phytochemistry;139:8-17, 2017 Jul.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The genus Hypoxylon, a member of the family Xylariaceae, has been known to produce significant secondary metabolites in terms of chemical diversity. Moreover, the compounds isolated can also be used as chemotaxonomic characters for differentiation among the two sections, which are sect. Annulata and sect. Hypoxylon. In our continuing chemical screening programme for novel compounds, the crude extracts of H. fendleri BCC32408 gave significant chemical profiles in HPLC analyses. Thus, the chemical investigation of these crude extracts was then carried out. The investigation led to the isolation of ten previously undescribed compounds including three terphenylquinones (fendleryls A - C), one terphenyl (fendleryl D), and six novel drimane - phthalide-type lactone/isoindolinones derivatives (fendlerinines A - F) along with seven known compounds (2-O-methylatromentin, rickenyl E, atromentin, rickenyls C - D, (+)-ramulosin, and O-hydroxyphenyl acetic acid). The chemical structures were determined on the basis of spectroscopic analyses, including 1D, 2D NMR and high-resolution mass spectrometry, as well as chemical transformations. In addition, these isolated compounds were assessed for antimicrobial activity including antimalarial (against Plasmodium falciparum, K-1 strain), antifungal (against Candida albicans), antibacterial (against Bacillus cereus) activities. Cytotoxicity against both cancerous (KB, MCF-7, NCI-H187) and non-cancerous (Vero) cells of these compounds were also evaluated.
[Mh] Termos MeSH primário: Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Antimaláricos/isolamento & purificação
Antimaláricos/farmacologia
Sesquiterpenos/isolamento & purificação
Compostos de Terfenil/isolamento & purificação
Compostos de Terfenil/farmacologia
Xylariales/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antifúngicos/química
Antimaláricos/química
Bacillus cereus/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Células KB
Lactonas/química
Testes de Sensibilidade Microbiana
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fenilacetatos/química
Plasmodium falciparum/efeitos dos fármacos
Sesquiterpenos/química
Sesquiterpenos/farmacologia
Compostos de Terfenil/química
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Antimalarials); 0 (Lactones); 0 (Phenylacetates); 0 (Sesquiterpenes); 0 (Terphenyl Compounds); 0 (drimane); UK3R9Q59AV (2-hydroxyphenylacetic acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170804
[Lr] Data última revisão:
170804
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE


  4 / 373 MEDLINE  
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[PMID]:28259974
[Au] Autor:Wang Y; Compton C; Rankin GO; Cutler SJ; Rojanasakul Y; Tu Y; Chen YC
[Ad] Endereço:Department of Tea Science, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China.
[Ti] Título:3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells.
[So] Source:Int J Oncol;50(4):1392-1402, 2017 Apr.
[Is] ISSN:1791-2423
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:In the present study, we evaluated 3-Hydroxyter-phenyllin (3-HT) as a potential anticancer agent using the human ovarian cancer cells A2780/CP70 and OVCAR-3, and normal human epithelial ovarian cells IOSE-364 as an in vitro model. 3-HT suppressed proliferation and caused cytotoxicity against A2780/CP70 and OVCAR-3 cells, while it exhibited lower cytotoxicity in IOSE-364 cells. Subsequently, we found that 3-HT induced S phase arrest and apoptosis in a dose-independent manner. Further investigation revealed that S phase arrest was related with DNA damage which mediated the ATM/p53/Chk2 pathway. Downregulation of cyclin D1, cyclin A2, cyclin E1, CDK2, CDK4 and Cdc25C, and the upregulation of Cdc25A and cyclin B1 led to the accumulation of cells in S phase. The apoptotic effect was confirmed by Hoechst 33342 staining, depolarization of mitochondrial membrane potential and activation of cleaved caspase-3 and PARP1. Additional results revealed both intrinsic and extrinsic apoptotic pathways were involved. The intrinsic apoptotic pathway was activated through decreasing the protein levels of Bcl2, Bcl-xL and procaspase-9 and increasing the protein level of Puma. The induction of DR5 and DR4 indicated that the extrinsic apoptotic pathway was also activated. Induction of ROS and activation of ERK were observed in ovarian cancer cells. We therefore concluded that 3-HT possessed anti-proliferative effect on A2780/CP70 and OVCAR-3 cells, induced S phase arrest and caused apoptosis. Taken together, we propose that 3-HT shows promise as a therapeutic candidate for treating ovarian cancer.
[Mh] Termos MeSH primário: Antineoplásicos/uso terapêutico
Apoptose/efeitos dos fármacos
Aspergillus/química
Proteínas de Ciclo Celular/metabolismo
Neoplasias Ovarianas/tratamento farmacológico
Pontos de Checagem da Fase S do Ciclo Celular/efeitos dos fármacos
Compostos de Terfenil/uso terapêutico
[Mh] Termos MeSH secundário: Proteínas Mutadas de Ataxia Telangiectasia/metabolismo
Linhagem Celular Transformada
Linhagem Celular Tumoral
Quinase do Ponto de Checagem 2/metabolismo
Dano ao DNA/efeitos dos fármacos
Células Epiteliais
Feminino
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Ovário/citologia
Poli(ADP-Ribose) Polimerase-1/metabolismo
Transdução de Sinais
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Cell Cycle Proteins); 0 (Terphenyl Compounds); 0 (Tumor Suppressor Protein p53); EC 2.4.2.30 (PARP1 protein, human); EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1); EC 2.7.1.11 (Checkpoint Kinase 2); EC 2.7.11.1 (ATM protein, human); EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins); EC 2.7.11.1 (CHEK2 protein, human); VEZ2NX1645 (3-hydroxyterphenyllin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.3892/ijo.2017.3894


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[PMID]:27976519
[Au] Autor:Liu X; Kong F; Cheng T; Chen W; Tan Z; Yu T; Guo F; Chen J; Yao J; Dai S
[Ad] Endereço:Key Laboratory of Novel Thin-film Solar Cells, Institute of Applied Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, 230088, P.R. China.
[Ti] Título:Tetraphenylmethane-Arylamine Hole-Transporting Materials for Perovskite Solar Cells.
[So] Source:ChemSusChem;10(5):968-975, 2017 Mar 09.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A new class of hole-transporting materials (HTM) containing tetraphenylmethane (TPM) core have been developed. After thermal, charge carrier mobility, and contact angle tests, it was found that TPA-TPM (TPA: arylamine derivates side group) showed higher glass-transition temperature and larger water-contact angle than spiro-OMeTAD with comparable hole mobility. Photoluminescence and impedance spectroscopy studies indicate that TPA-TPM's hole-extraction ability is comparable to that of spiro-OMeTAD. SEM and AFM results suggest that TPA-TPM has a smooth surface. When TPA-TPM is used in mesoscopic perovskite solar cells, power conversion efficiency comparable to that of spiro-OMeTAD is achieved. Notably, the perovskite solar cells employing TPA-TPM show better long-term stability than that of spiro-OMeTAD. Moreover, TPA-TPM can be prepared from relatively inexpensive raw materials with a facile synthetic route. The results demonstrate that TPM-arylamines are a new class of HTMs for efficient and stable perovskite solar cells.
[Mh] Termos MeSH primário: Aminas/química
Compostos de Cálcio/química
Fontes de Energia Elétrica
Metano/análogos & derivados
Óxidos/química
Energia Solar
Compostos de Terfenil/química
Titânio/química
[Mh] Termos MeSH secundário: Metano/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amines); 0 (Calcium Compounds); 0 (Oxides); 0 (Terphenyl Compounds); 0 (tetraphenylmethane); 12194-71-7 (perovskite); D1JT611TNE (Titanium); OP0UW79H66 (Methane)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201601683


  6 / 373 MEDLINE  
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[PMID]:27887840
[Au] Autor:Yan W; Wuringege; Li SJ; Guo ZK; Zhang WJ; Wei W; Tan RX; Jiao RH
[Ad] Endereço:College of Plant Protection, State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing 210095, PR China.
[Ti] Título:New p-terphenyls from the endophytic fungus Aspergillus sp. YXf3.
[So] Source:Bioorg Med Chem Lett;27(1):51-54, 2017 01 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five new p-terphenyls named prenylterphenyllin D (1), prenylterphenyllin E (2), 2'-O-methylprenylterphenyllin (3), 4-O-methylprenylterphenyllin (4) and 3'-O-methylterphenyllin (5) together with seven known compounds (6-12), were isolated from cultures of Aspergillus sp. YXf3. The structures of the new compounds were elucidated by extensive MS and NMR analyses. The NMR and MS data of 5 is reported for the first time, as its structure was listed in SciFinder Scholar with no associated reference. Compounds 6 and 7 were distinguished from each other on the basis of 2D NMR experiments. Compounds 1, 2, 3 and 8 showed antibacterial activities against X. oryzae pv. oryzicola Swings and E. amylovora with the same MIC values of 20µg/mL while 10 exhibited activities against E. amylovora with an MIC value of 10µg/mL.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Aspergillus/química
Erwinia amylovora/efeitos dos fármacos
Compostos de Terfenil/farmacologia
Xanthomonas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Relação Dose-Resposta a Droga
Testes de Sensibilidade Microbiana
Estrutura Molecular
Relação Estrutura-Atividade
Compostos de Terfenil/química
Compostos de Terfenil/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Terphenyl Compounds)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE


  7 / 373 MEDLINE  
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[PMID]:27626606
[Au] Autor:Punganuru SR; Samala R; Srivenugopal KS
[Ad] Endereço:Sadhvi Pharma, Kukatpally IE, Hyderabad, India.
[Ti] Título:One-pot Synthesis and Antitumor Activity of Unsymmetrical Terphenyls.
[So] Source:Drug Res (Stuttg);67(1):25-31, 2017 Jan.
[Is] ISSN:2194-9387
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In this paper a simple and efficient method for the unsymmetrical terphenyls via sequential one-pot Suzuki coupling reactions using Pd(OAc) without isolation of the intermediate is described. The prepared terphenyls were found to possess potent anticancer properties against a panel of cancer cells which includes A549, HeLa, MCF7, DU145, HT29 and BxPC-3. Structural similarity with combretastatin A4, these terphenyls disrupted the tubulin polymerization in vitro and destabilized the microtubules in cells. Flow cytometry studies indicated growth arrest of cells in the G2/M phase of the cell cycle corresponding to antimitotic action. Furthermore, compound showed potent anti-mitotic activity even in zebrafish model and could likely be a potential therapeutic compound as it is active both in and .
[Mh] Termos MeSH primário: Compostos de Terfenil/síntese química
Compostos de Terfenil/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/síntese química
Antineoplásicos Fitogênicos/farmacologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Microtúbulos/efeitos dos fármacos
Polimerização/efeitos dos fármacos
Relação Estrutura-Atividade
Tubulina (Proteína)/metabolismo
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Terphenyl Compounds); 0 (Tubulin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-114776


  8 / 373 MEDLINE  
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[PMID]:27731998
[Au] Autor:Andernach L; Sandjo LP; Liermann JC; Schlämann R; Richter C; Ferner JP; Schwalbe H; Schüffler A; Thines E; Opatz T
[Ad] Endereço:Institute of Organic Chemistry, Johannes Gutenberg-University , Duesbergweg 10-14, D-55128 Mainz, Germany.
[Ti] Título:Terphenyl Derivatives from Allantophomopsis lycopodina.
[So] Source:J Nat Prod;79(10):2718-2725, 2016 Oct 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three secondary fungal metabolites 1-3 with a benzo[b]naphtho[2,1-d]furan skeleton were isolated from submerged cultures of the ascomycete Allantophomopsis lycopodina. The NMR-based structure elucidation was challenging due to a low H/C ratio of only 0.64 and 0.68, respectively. NMR measurements in two different solvents and the use of NMR experiments such as HSQC-TOCSY and LR-HSQMBC proved to be helpful in this respect. The proposed structures obtained from the comprehensive analysis of the NMR data were verified by comparison of recorded and computed NMR chemical shifts from quantum chemical calculations of several constitutional isomers and were further analyzed with the aid of the DP4 and DP4+ probabilities.
[Mh] Termos MeSH primário: Ascomicetos/química
Compostos de Terfenil/isolamento & purificação
[Mh] Termos MeSH secundário: Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Compostos de Terfenil/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Terphenyl Compounds)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170616
[Lr] Data última revisão:
170616
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


  9 / 373 MEDLINE  
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[PMID]:27725436
[Au] Autor:Hiromori Y; Ido A; Aoki A; Kimura T; Nagase H; Nakanishi T
[Ad] Endereço:Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University.
[Ti] Título:Ligand Activity of Group 15 Compounds Possessing Triphenyl Substituent for the RXR and PPARγ Nuclear Receptors.
[So] Source:Biol Pharm Bull;39(10):1596-1603, 2016.
[Is] ISSN:1347-5215
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:We investigated the ability of group 15 compounds with a triphenyl substituent to bind to and activate human retinoic X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) γ and their ability to activate the receptor. Triphenylphosphine oxide (TPPO) transcriptionally activated both RXR and PPARγ. Triphenylbismuth (TPBi) transcriptionally activated PPARγ but not RXR. However, TPBi significantly inhibited RXR transcriptional activity induced by 9-cis retinoic acid (9cRA) and PPARγ transcriptional activity induced by rosiglitazone (Rosi). Triphenylarsine (TPAs) also significantly inhibited the 9cRA- and Rosi-induced transcriptional activity of both receptors, whereas TPAs alone had no effect on the transcriptional activity of RXR and PPARγ. Consistent with these results, TPAs and TPBi blocked the binding of [ H]9cRA to RXR and of [ H]Rosi to PPARγ in a competitive manner. However, contrary to the results of the reporter gene assay, TPPO did not compete with [ H]9cRA and [ H]Rosi for binding to RXR and PPARγ, respectively. Our findings indicate that 1) TPPO is a transcriptional activator-but not a ligand-of RXR and PPARγ; 2) TPBi is an antagonist of RXR and a partial agonist of PPARγ; and 3) TPAs is a dual antagonist of RXR and PPARγ. These results suggest that TPPO, TPAs, and TPBi are potential endocrine disrupters of the PPARγ-RXR signaling pathway.
[Mh] Termos MeSH primário: Arsenicais/farmacologia
Compostos Organometálicos/farmacologia
Compostos Organofosforados/farmacologia
PPAR gama/metabolismo
Receptores X Retinoide/metabolismo
Compostos de Terfenil/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
DNA/metabolismo
Genes Reporter
Seres Humanos
Ligantes
Luciferases de Renilla/genética
PPAR gama/agonistas
PPAR gama/genética
Receptores X Retinoide/agonistas
Receptores X Retinoide/genética
Tiazolidinedionas/farmacologia
Transcrição Genética/efeitos dos fármacos
Tretinoína/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Ligands); 0 (Organometallic Compounds); 0 (Organophosphorus Compounds); 0 (PPAR gamma); 0 (Retinoid X Receptors); 0 (Terphenyl Compounds); 0 (Thiazolidinediones); 05V02F2KDG (rosiglitazone); 1UA8E65KDZ (alitretinoin); 5688UTC01R (Tretinoin); 9007-49-2 (DNA); EC 1.13.12.5 (Luciferases, Renilla); R18732F41W (triphenyl bismuth); Z69161FKI3 (triphenylphosphine oxide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE


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[PMID]:27557136
[Au] Autor:Li W; Gao W; Zhang M; Li YL; Li L; Li XB; Chang WQ; Zhao ZT; Lou HX
[Ad] Endereço:Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , No. 44 West Wenhua Road, Jinan 250012, China.
[Ti] Título:p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata.
[So] Source:J Nat Prod;79(9):2188-94, 2016 Sep 23.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ten new p-terphenyl derivatives, floricolins A-J (1-10), together with six known compounds (11-16), were isolated from the extract of the endolichenic fungus Floricola striata. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 and 10 were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Evaluation of the isolated compounds against Candida albicans revealed that the most active compound, 3 (MIC 8 µg/mL), exerted fungicidal action by destruction of the cell membrane.
[Mh] Termos MeSH primário: Ascomicetos/química
Compostos de Terfenil/isolamento & purificação
[Mh] Termos MeSH secundário: Antibacterianos/química
Candida albicans/efeitos dos fármacos
Cristalografia por Raios X
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Staphylococcus aureus/efeitos dos fármacos
Compostos de Terfenil/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Terphenyl Compounds)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00197



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