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Pesquisa : D02.455.426.559.389.805.700 [Categoria DeCS]
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[PMID]:26183822
[Au] Autor:Wichmann H; Schäfer K; Ibrom K; Jüttner F; Saatz J; Vogt R; Bahadir M
[Ad] Endereço:Technische Universität Braunschweig, Institute of Environmental and Sustainable Chemistry, Hagenring 30, 38106 Braunschweig, Germany. Electronic address: hu.wichmann@tu-bs.de.
[Ti] Título:Synthesis of coplanar PCT as reference substances for the residue analysis of polychlorinated terphenyls.
[So] Source:Chemosphere;137:157-65, 2015 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the course of the development of a new and reliable analytical method for the PCT, a group of environmental contaminants, six coplanar terphenyl congeners were synthesized and characterized by means of spectroscopic methods. These congeners are 3,3″,4,4″,5-pentachloro-p-terphenyl, 3,3″,4,5,5″-pentachloro-p-terphenyl, 3,3″,4,5″-tetrachloro-m-terphenyl, 3,3″,4,4″,5-pentachloro-m-terphenyl, 3,3″,5,5',5″-pentachloro-m-terphenyl, and 3,3″,4,4″,5,5″-hexachloro-m-terphenyl. A combination of silica gel column chromatography and preparative NP-HPLC was successfully applied for the first time for the isolation of especially the asymmetrically chlorinated target compounds from product mixtures of the syntheses. For the 29 coplanar, tetra- to heptachlorinated meta- and para-indicator congeners which are envisaged to be used within the analytical method, a simplified systematic nomenclature is suggested. Furthermore, calculation results for all torsion angles of the preferred conformations of the substances are given. The practical relevance of the calculated conformation optima is exemplarily demonstrated by the chromatographic behavior of the PCT compounds.
[Mh] Termos MeSH primário: Poluentes Ambientais/análise
Poluentes Ambientais/síntese química
Compostos de Policloroterfenilo/análise
Compostos de Policloroterfenilo/síntese química
[Mh] Termos MeSH secundário: Poluentes Ambientais/química
Cromatografia Gasosa-Espectrometria de Massas
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Compostos de Policloroterfenilo/química
Padrões de Referência
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Polychloroterphenyl Compounds)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150815
[Lr] Data última revisão:
150815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE


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[PMID]:21875097
[Au] Autor:Simão C; Mas-Torrent M; Veciana J; Rovira C
[Ad] Endereço:Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Campus de la UAB , 08193 Bellaterra, Spain.
[Ti] Título:Multichannel molecular switch with a surface-confined electroactive radical exhibiting tunable wetting properties.
[So] Source:Nano Lett;11(10):4382-5, 2011 Oct 12.
[Is] ISSN:1530-6992
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A multichannel surface molecular switch based on self-assembled monolayers (SAMs) on gold of a novel polychlorotriphenylmethyl radical has been fabricated. These SAMs are electrically commutable between two stable redox states that reveal distinct magnetic, optical, and wetting properties that can be employed as read-out mechanisms. The high stability and reversibility of systems like the one reported here further supports the vision of using molecules in the electronic devices of the future.
[Mh] Termos MeSH primário: Propriedades de Superfície
Molhabilidade
[Mh] Termos MeSH secundário: Eletroquímica
Ouro/química
Compostos de Policloroterfenilo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Polychloroterphenyl Compounds); 7440-57-5 (Gold)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:111012
[Lr] Data última revisão:
111012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110831
[St] Status:MEDLINE
[do] DOI:10.1021/nl2025097


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[PMID]:21365702
[Au] Autor:Datcu A; Roques N; Jubera V; Imaz I; Maspoch D; Sutter JP; Rovira C; Veciana J
[Ad] Endereço:Departament de Nanociència Molecular i Materials Orgànics, Institut de Ciència de Materials de Barcelona, Campus de la UAB, 08193 Bellaterra, Spain.
[Ti] Título:Three-dimensional open-frameworks based on Ln(III) ions and open-/closed-shell PTM ligands: synthesis, structure, luminescence, and magnetic properties.
[So] Source:Chemistry;17(13):3644-56, 2011 Mar 21.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A series of isostructural open-framework coordination polymers formulated as [Ln(dmf)(3)(ptmtc)] (Ln = Sm (1), Eu (2), Gd (3), Tb (4), Dy (5); PTMTC = polychlorotriphenylmethyl tricarboxylate) and [Ln(dmf)(2)H(2)O(αH-ptmtc)] (Ln = Sm (1'), Eu (2'), Gd (3'), Tb (4'), Dy (5')) have been obtained by treating Ln(III) ions with PTMTC ligands with a radical (PTMTC(3-)) or a closed-shell character (αH-PTMTC(3-)). X-ray diffraction analyses reveal that these coordination polymers possess 3D architectures that combine large channels and fairly rare lattice complex T connectivity. In addition, these compounds show selective framework dynamic sorption properties. For both classes of ligands, the ability to act as an antenna in Ln sensitization processes has been investigated. No luminescence was observed for compounds 1-5, and 3' because of the PTMTC(3-) ligand and/or Gd(III) ion characteristics. Conversely, photoluminescence measurements show that 1', 2', 4', and 5' emit dark orange, red, green, and dark cyan metal-centered luminescence. The magnetic properties of all of these compounds have been investigated. The nature of the {Ln-radical} exchange interaction in these compounds has been assessed by comparing the behavior of the radical-based coordination polymers 1-5 with those of the compounds with the diamagnetic ligand set. While antiferromagnetic {Sm-radical} interactions are found in 1, ferromagnetic {Ln-radical} interactions propagate in the 3D architectures of 3, 4, and 5 (Ln = Gd, Tb, and Dy, respectively). This procedure also provided access to information on the {Ln-Ln} exchange existing in these magnetic systems.
[Mh] Termos MeSH primário: Íons/química
Elementos da Série dos Lantanídeos/química
Metais/química
Compostos de Policloroterfenilo/química
Compostos de Policloroterfenilo/síntese química
[Mh] Termos MeSH secundário: Cristalografia por Raios X
Ligantes
Luminescência
Magnetismo
Modelos Moleculares
Conformação Molecular
Estrutura Molecular
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Ions); 0 (Lanthanoid Series Elements); 0 (Ligands); 0 (Metals); 0 (Polychloroterphenyl Compounds)
[Em] Mês de entrada:1106
[Cu] Atualização por classe:110311
[Lr] Data última revisão:
110311
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110303
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201002993


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[PMID]:20454741
[Au] Autor:Paniagua JC; Mugnaini V; Gabellieri C; Feliz M; Roques N; Veciana J; Pons M
[Ad] Endereço:Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain.
[Ti] Título:Polychlorinated trityl radicals for dynamic nuclear polarization: the role of chlorine nuclei.
[So] Source:Phys Chem Chem Phys;12(22):5824-9, 2010 Jun 14.
[Is] ISSN:1463-9084
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polychlorinated trityl radicals bearing carboxylate substituents are water soluble persistent radicals that can be used for dynamic nuclear polarization. In contrast to other trityl radicals, the polarization mechanism differs from the classical solid effect. DFT calculations performed to rationalize this behaviour support the hypothesis that polarization is transferred from the unpaired electron to chlorine nuclei and from these to carbon by spin diffusion. The marked differences observed between neutral and anionic forms of the radical will be discussed.
[Mh] Termos MeSH primário: Cloro/química
Radicais Livres/química
Espectroscopia de Ressonância Magnética/métodos
Compostos de Policloroterfenilo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Free Radicals); 0 (Polychloroterphenyl Compounds); 4R7X1O2820 (Chlorine)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100511
[St] Status:MEDLINE
[do] DOI:10.1039/c003291n


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[PMID]:19707252
[Au] Autor:Lopez-Espinosa MJ; Vizcaino E; Murcia M; Fuentes V; Garcia AM; Rebagliato M; Grimalt JO; Ballester F
[Ad] Endereço:Centre for Public Health Research, Environmental and Health Research Area, Conselleria de Sanitat, Generalitat Valenciana, Valencia, Spain. lopez_josesp@gva.es
[Ti] Título:Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels.
[So] Source:J Expo Sci Environ Epidemiol;20(7):579-88, 2010 Nov.
[Is] ISSN:1559-064X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It has been suggested that prenatal exposure to some organochlorine compounds (OCs) may adversely affect thyroid function and may, therefore, impair neurodevelopment. The main aim of this study was to examine the relationship of cord serum levels of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4'-DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4'-DDE), ß-hexachlorocyclohexane (ß-HCH), hexachlorobenzene (HCB), four individual polychlorobiphenyl (PCB) congeners (118, 138, 153, and 180), and their sum, with neonatal thyroid stimulating hormone (TSH) levels in blood samples in a mother-infant cohort in Valencia, Spain. This study included 453 infants born between 2004 and 2006. We measured OC concentrations in umbilical cord serum and TSH in blood of newborns shortly after birth. Associations between neonatal TSH levels and prenatal OC exposure adjusted for covariates were assessed using multivariate linear regression analyses. Neonatal TSH levels tended to be higher in newborns with ß-HCH levels in umbilical cord above 90th percentile (104 ng/g lipid) than in those with levels below the median (34 ng/g lipid), with an adjusted increment in neonatal TSH levels of 21% (95% confidence interval=-3, 51; P=0.09). No statistically significant association was found between the remaining OCs and TSH at birth. Prenatal exposure to ß-HCH may affect neonatal thyroid hormone status and its function in neurological development.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados/efeitos adversos
Recém-Nascido/sangue
Efeitos Tardios da Exposição Pré-Natal/sangue
Tireotropina/sangue
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Coortes
DDT/efeitos adversos
DDT/sangue
Diclorodifenil Dicloroetileno/efeitos adversos
Diclorodifenil Dicloroetileno/sangue
Exposição Ambiental/efeitos adversos
Exposição Ambiental/análise
Feminino
Sangue Fetal/química
Hexaclorobenzeno/efeitos adversos
Hexaclorobenzeno/sangue
Seres Humanos
Lindano/efeitos adversos
Lindano/sangue
Masculino
Compostos de Policloroterfenilo/efeitos adversos
Compostos de Policloroterfenilo/sangue
Gravidez
Análise de Regressão
Espanha
Glândula Tireoide/efeitos dos fármacos
Glândula Tireoide/embriologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Hydrocarbons, Chlorinated); 0 (Polychloroterphenyl Compounds); 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene); 4Z87H0LKUY (Hexachlorobenzene); 59NEE7PCAB (Lindane); 9002-71-5 (Thyrotropin); CIW5S16655 (DDT); YM80ODM9PD (beta-hexachlorocyclohexane)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090827
[St] Status:MEDLINE
[do] DOI:10.1038/jes.2009.47


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[PMID]:19361165
[Au] Autor:Crivillers N; Furukawa S; Minoia A; Ver Heyen A; Mas-Torrent M; Sporer C; Linares M; Volodin A; Van Haesendonck C; Van der Auweraer M; Lazzaroni R; De Feyter S; Veciana J; Rovira C
[Ad] Endereço:Institut de Ciencia de Materials de Barcelona (ICMAB-CSIC), Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Bellaterra, Spain.
[Ti] Título:Two-leg molecular ladders formed by hierarchical self-assembly of an organic radical.
[So] Source:J Am Chem Soc;131(17):6246-52, 2009 May 06.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The supramolecular organization of a new polychlorotriphenyl (PTM) radical bearing three long alkyl chains has been studied by scanning tunneling microscopy (STM) at the liquid-solid interface. This radical hierarchically self-assembles on graphite forming head-to-head dimers that organize in rows following an interesting spin-containing two-leg molecular ladder topology, in which the alkyl chains determine the space between the radical rows and act as diamagnetic barriers. In addition, these double-rows also self-assemble three-dimensionally, leading to a multilayer organization which is still influenced by the HOPG substrate symmetry. The observed nanostructures are sustained by different intermolecular interactions such as Cl...Cl, Cl...Ph, pi-pi, van der Waals, and CH...pi interactions. Theoretical calculations were used to model the observed assemblies, and the results were in complete agreement with the experimental data. Remarkably, atomic force microscopy (AFM) studies confirmed that this tendency to form double rows composed by the PTM magnetic heads surrounded by the alkyl chains is maintained after the complete evaporation of the solvent. The electrochemical and magnetic properties of these PTM nanostructures were also demonstrated.
[Mh] Termos MeSH primário: Compostos de Policloroterfenilo/química
[Mh] Termos MeSH secundário: Eletroquímica
Radicais Livres/síntese química
Radicais Livres/química
Substâncias Macromoleculares/síntese química
Substâncias Macromoleculares/química
Magnetismo
Microscopia de Força Atômica
Microscopia de Tunelamento
Conformação Molecular
Nanoestruturas/química
Tamanho da Partícula
Compostos de Policloroterfenilo/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Free Radicals); 0 (Macromolecular Substances); 0 (Polychloroterphenyl Compounds)
[Em] Mês de entrada:0907
[Cu] Atualização por classe:090429
[Lr] Data última revisão:
090429
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090414
[St] Status:MEDLINE
[do] DOI:10.1021/ja900453n


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[PMID]:18376836
[Au] Autor:Crivillers N; Mas-Torrent M; Vidal-Gancedo J; Veciana J; Rovira C
[Ad] Endereço:Institut de Ciència de Materials de Barcelona and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, Campus Universitari de Bellaterra, 08193 Cerdanyola del Vallès, Spain.
[Ti] Título:Self-assembled monolayers of electroactive polychlorotriphenylmethyl radicals on Au(111).
[So] Source:J Am Chem Soc;130(16):5499-506, 2008 Apr 23.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two new polychlorotriphenylmethyl (PTM) derivatives bearing a thioacetate and a disulfide group have been synthesized to anchor on gold substrate. On the basis of these molecules, three strategies were followed to prepare self-assembled monolayers (SAMs) of electroactive PTMs. The resulting SAMs were fully characterized by contact angle, atomic force microscopy (AFM), and time-of-flight secondary ion mass spectroscopy (ToF-SIMS). The high coverage surface and stability of the SAMs were demonstrated by cyclic voltammetry. In addition, the electrochemical experiments proved that these SAMs are bistable since it is possible to reversibly switch between the PTM radical state to the corresponding anion. The magnetic response was investigated by electron paramagnetic resonance. We observed that when the PTM SAMs are in their radical form they confer magnetic functionality to the surface, whereas when they are in the anionic state, the surface is diamagnetic. Thus, the PTM-modified substrates are multifunctional surfaces since they combine magnetic and electroactive properties. The reported results show the high potential of these materials for the fabrication of surface molecular devices.
[Mh] Termos MeSH primário: Materiais Biocompatíveis/síntese química
Radicais Livres/química
Ouro/química
Compostos de Policloroterfenilo/síntese química
[Mh] Termos MeSH secundário: Acetatos/química
Sítios de Ligação
Eletroquímica
Magnetismo
Teste de Materiais
Microscopia de Força Atômica
Espectrometria de Massa de Íon Secundário
Compostos de Sulfidrila/química
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Biocompatible Materials); 0 (Free Radicals); 0 (Polychloroterphenyl Compounds); 0 (Sulfhydryl Compounds); 7440-57-5 (Gold)
[Em] Mês de entrada:0807
[Cu] Atualização por classe:080418
[Lr] Data última revisão:
080418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080402
[St] Status:MEDLINE
[do] DOI:10.1021/ja710845v


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[PMID]:17967745
[Au] Autor:Covaci A; Kawaki P; Indekeu C; Schepens P; Neels H
[Ad] Endereço:Toxicological Centre, University of Antwerp, Wilrijk, Belgium. adrian.covaci@ua.ac.be
[Ti] Título:Highly chlorinated toxic contaminants in pesticide-treated wooden art objects.
[So] Source:Arch Environ Occup Health;61(6):245-8, 2006 Nov-Dec.
[Is] ISSN:1933-8244
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although the contamination of wooden art objects with pesticides is well known, to the authors' knowledge no attempt has yet been made to investigate the eventual presence of other toxic compounds that have been produced during the degradation of pesticides or that may be present in the technical formulations. Here, the authors report on the presence of polychlorinated biphenyls (PCBs) and polychlorinated terphenyls (PCTs) in scrapings from wooden antique art objects, namely printing blocks, sculptures, and masks. These antiques belong to 2 fine art museums in Belgium--Antwerp's Ethnographic Museum and the Plantin-Moretus Museum. It is documented that these art objects were treated with pesticides in the 1950s. In addition, 2-heptachlorodibenzo-p-dioxin (HpCDD) isomers and octachlorodibenzo-p-dioxin (OCDD) were also identified. The presence of these toxic compounds in these antiques requires a better understanding of safety for the persons (conservators, museum employees, restorers, and visitors) coming in contact with these objects.
[Mh] Termos MeSH primário: Arte
Poluentes Ambientais/química
Praguicidas/química
Madeira/química
[Mh] Termos MeSH secundário: Seres Humanos
Bifenilos Policlorados/química
Compostos de Policloroterfenilo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Pesticides); 0 (Polychloroterphenyl Compounds); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:0711
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:071031
[St] Status:MEDLINE


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[PMID]:12547328
[Au] Autor:Bahadir M; Pieper A; Vogt R; Wichmann H; Grunenberg J; Hopf H
[Ad] Endereço:Institute of Ecological Chemistry and Waste Analysis, TU Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany. m.bahadir@tu-be.de
[Ti] Título:Isomer specific synthesis using the Suzuki-coupling. Polychlorinated terphenyls as standards for environmental analysis.
[So] Source:Chemosphere;50(9):1151-6, 2003 Mar.
[Is] ISSN:0045-6535
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Defined polychlorinated terphenyl (PCT) single congeners as reference standards are the prerequisite for the development of analytical methods for their determination and quantification in the environment. The selective synthesis of PCTs for environmental analytical purposes by application of the Suzuki-coupling reaction is described. Under easily modified standard reaction conditions of this coupling process the PCTs can be obtained by reaction of benzeneboronic acids with dibromobenzenes mostly in good yields, as described by the synthesis of following PCT congeners: p-PCT (3,3("),5,5(")-tetrachloro-, 2,2("),4,4(")-tetrachloro-, 2('),3,3("),5,5(")-pentachloro-); m-PCT (3,3("),5,5(")-tetrachloro-) and o-PCT (3,3("),5,5(")-tetrachloro-). The terphenyl congeners were characterized by NMR (1H, 13C)- and FT-IR-spectroscopy. Their purity was checked by GC/MS analysis. The experimental and quantum-chemically calculated FT-IR-spectra were compared and it was shown, that the determination of the chlorine substitution pattern in the terphenyl congeners by their typical absorption spectra is possible.
[Mh] Termos MeSH primário: Monitoramento Ambiental/normas
Poluentes Ambientais/síntese química
Compostos de Policloroterfenilo/síntese química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Isomerismo
Espectroscopia de Ressonância Magnética
Compostos de Policloroterfenilo/química
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Polychloroterphenyl Compounds)
[Em] Mês de entrada:0305
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030128
[St] Status:MEDLINE


  10 / 41 MEDLINE  
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[PMID]:12507654
[Au] Autor:Schrader TJ; Cooke GM
[Ad] Endereço:Toxicology Research Division, Health Products and Foods Branch, Food Directorate, Health Canada, Sir Frederick G Banting Research Centre, 2202D1 Tunney's Pasture, Ottawa, Ont, Canada K1A 0L2.
[Ti] Título:Effects of Aroclors and individual PCB congeners on activation of the human androgen receptor in vitro.
[So] Source:Reprod Toxicol;17(1):15-23, 2003 Jan-Feb.
[Is] ISSN:0890-6238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To investigate possible interactions between the human androgen receptor and PCBs in vitro, we have used a previously characterized human androgen receptor reporter gene assay in which PC-3 LUC(AR+) cells respond to 5alpha-dihydrotestosterone (DHT, 50 pM) with enhanced luciferase activity. The effects of Aroclors, commercial mixtures of PCBs, or polychlorinated terphenyls (PCTs) (0, 0.1, 1.0, and 10.0 microM) on luciferase activity in PC-3 LUC(AR+) cells were determined after exposure for 18 h in the presence and absence of DHT (50 pM). In the absence of DHT, none of the Aroclors induced luciferase activity but, in the presence of DHT (50 pM), Aroclors 1016, 1221, 1232, 1242, 1248, 1254, 1260, 5432, and 5442 acted antagonistically at concentrations that did not affect cell viability. Aroclor 5460 was without effect. Similarly, when PCBs found as human milk contaminants were assessed as individual congeners (each at 1 microM, where no cytotoxic effects were observed), none activated luciferase expression in the absence of DHT but PCBs 49, 66, 74, 105, and 118 completely antagonized the stimulation by DHT (50 pM) and PCBs 138, 153, and 156 were less effective antagonists, reducing the DHT stimulation by about 50%. Thus, 30% (by weight) of the PCBs in human milk are androgen antagonists (PCBs 66, 74, 105, and 118) and a further 25% are partial antagonists (PCBs 138, 153, and 156). A proportionally representative mixture of PCBs that contaminate human milk also caused the DHT-mediated activation of luciferase activity in PC-3 LUC(AR+) cells to be reduced by more than 50%.
[Mh] Termos MeSH primário: Antagonistas de Androgênios/toxicidade
Arocloros/toxicidade
Poluentes Ambientais/toxicidade
Receptores Androgênicos/metabolismo
[Mh] Termos MeSH secundário: Androgênios
Carcinoma/tratamento farmacológico
Carcinoma/metabolismo
Carcinoma/patologia
Sobrevivência Celular/efeitos dos fármacos
Di-Hidrotestosterona/farmacologia
Relação Dose-Resposta a Droga
Combinação de Medicamentos
Feminino
Genes Reporter/genética
Seres Humanos
Luciferases/antagonistas & inibidores
Luciferases/genética
Luciferases/metabolismo
Masculino
Leite Humano/química
Compostos de Policloroterfenilo/toxicidade
Neoplasias da Próstata/tratamento farmacológico
Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/patologia
Transfecção
Células Tumorais Cultivadas/efeitos dos fármacos
Células Tumorais Cultivadas/metabolismo
Células Tumorais Cultivadas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androgen Antagonists); 0 (Androgens); 0 (Aroclors); 0 (Drug Combinations); 0 (Environmental Pollutants); 0 (Polychloroterphenyl Compounds); 0 (Receptors, Androgen); 08J2K08A3Y (Dihydrotestosterone); EC 1.13.12.- (Luciferases)
[Em] Mês de entrada:0306
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030101
[St] Status:MEDLINE



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