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[PMID]:29069003
[Au] Autor:Chen HB; Lian-Xiang P; Yue H; Chun H; Shu-Ping X; Rong-Pang L; Xiao-Zong W; Xiao-Lin L
[Ad] Endereço:aDepartment of Gastroenterology, Sanming First Hospital Affiliated to Fujian Medical University, Sanming bDepartment of Gastroenterology, Fujian Medical University Union Hospital, Fuzou cDepartment of Cardiology, Fu Wai Hospital of Chinese Academy of Medical Sciences of Peking Union Medical College, Peking, China.
[Ti] Título:Randomized controlled trial of 3 days fasting and oral senna, combined with mannitol and simethicone, before capsule endoscopy.
[So] Source:Medicine (Baltimore);96(43):e8322, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND STUDY AIMS: The approach to small bowel preparation before capsule endoscopy (CE) is still suboptimal. PATIENTS AND METHODS: One hundred eighty patients were randomly allocated to 3 groups. Patients in Group A took 250 mL 20% mannitol and 1 L 0.9% saline orally at 05:00 hours on the day of the procedure. In Group B the same preparation was taken at 20:00 on the day before, and at 05:00 on the day of CE; in addition, 20 mL oral simethicone was taken 30 minutes before CE. Group C was treated identically to Group B, except that the patients fasted for 3 days and took 3 g senna orally 3 times daily before CE. The length of bowel containing green luminal contents was assessed by ImageJ software and bowel cleanliness was evaluated by computed assessment of the cleansing score. RESULTS: Cleansing of the whole small bowel and the distal small bowel were significantly different between the 3 groups (χ = 22.470, P = .000; χ = 17.029, P = .000, respectively). There were also significant differences between the 3 groups in the length of small bowel and specifically the length of the distal small bowel containing green luminal contents (χ = 12.390, P = .000, χ = 15.141, P = .000, respectively), but not with regard to the proximal small bowel (χ = 0.678, P = .509). CONCLUSIONS: Three days fasting and oral senna, combined with 20% mannitol and simethicone, before CE, can reduce the effects of bile on the small bowel and improve small bowel cleansing, especially in the distal small intestine.
[Mh] Termos MeSH primário: Endoscopia por Cápsula
Catárticos/administração & dosagem
Intestino Delgado
Manitol/administração & dosagem
Extrato de Sena/administração & dosagem
Simeticone/administração & dosagem
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Idoso
Endoscopia por Cápsula/efeitos adversos
Endoscopia por Cápsula/métodos
Esquema de Medicação
Jejum
Feminino
Gastroenteropatias/diagnóstico
Seres Humanos
Intestino Delgado/efeitos dos fármacos
Intestino Delgado/fisiopatologia
Masculino
Meia-Idade
Planejamento de Assistência ao Paciente
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cathartics); 3OWL53L36A (Mannitol); 8013-11-4 (Senna Extract); 8050-81-5 (Simethicone)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008322


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[PMID]:28345979
[Au] Autor:Bardsley A
[Ad] Endereço:Senior Lecturer, Course Director Non-Medical Prescribing, Coventry University.
[Ti] Título:Assessment and treatment options for patients with constipation.
[So] Source:Br J Nurs;26(6):312-318, 2017 03 23.
[Is] ISSN:0966-0461
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Constipation is a common complaint for people of all ages, with prevalence increasing with age and during pregnancy. Women are more likely to be affected than men. Severity of constipation varies from person to person; most people experience short periods of constipation during their lives, including possibly after surgery, while others have constipation as a chronic long-term condition that can significantly affect their quality of life. There are a number of factors that can contribute to developing constipation including diets low in fibre, changes in lifestyle, side effects of certain medications and low fluid intake. People can successfully treat constipation by making changes to their diet and lifestyle. However, medication may be required to manage constipation for some.
[Mh] Termos MeSH primário: Constipação Intestinal/enfermagem
Dietoterapia
Laxantes/uso terapêutico
Avaliação em Enfermagem
[Mh] Termos MeSH secundário: Catárticos/uso terapêutico
Constipação Intestinal/diagnóstico
Constipação Intestinal/terapia
Gerenciamento Clínico
Seres Humanos
Lactulose/uso terapêutico
Metilcelulose/uso terapêutico
Peptídeos/uso terapêutico
Polietilenoglicóis/uso terapêutico
Qualidade de Vida
Extrato de Sena/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cathartics); 0 (Laxatives); 0 (Peptides); 30IQX730WE (Polyethylene Glycols); 4618-18-2 (Lactulose); 8013-11-4 (Senna Extract); 9004-67-5 (Methylcellulose); N0TXR0XR5X (linaclotide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.12968/bjon.2017.26.6.312


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[PMID]:28274853
[Au] Autor:Lee SY; Kim W; Lee YG; Kang HJ; Lee SH; Park SY; Min JK; Lee SR; Chung SJ
[Ad] Endereço:Department of Chemistry, Dongguk University, Seoul 100-715, Republic of Korea.
[Ti] Título:Identification of sennoside A as a novel inhibitor of the slingshot (SSH) family proteins related to cancer metastasis.
[So] Source:Pharmacol Res;119:422-430, 2017 May.
[Is] ISSN:1096-1186
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Phospho-cofilin (p-cofilin), which has a phosphate group on Ser-3, is involved in actin polymerization. Its dephosphorylated form promotes filopodia formation and cell migration by enhancing actin depolymerization. Protein phosphatase slingshot homologs (SSHs), known as dual-specificity phosphatases, catalyze hydrolytic removal of the Ser-3 phosphate group from phospho-cofilin. Aberrant SSH activity results in cancer metastasis, implicating SSHs as potential therapeutic targets for cancer metastasis. In this study, we screened 658 natural products purified from traditional oriental medicinal plants to identify three potent SSH inhibitors with submicromolar or single-digit micromolar K values: gossypol, hypericin, and sennoside A. The three compounds were purified from cottonseed, Saint John's wort, and rhubarb, respectively. Sennoside A markedly increased cofilin phosphorylation in pancreatic cancer cells, leading to impaired actin dynamics in pancreatic cancer cells with or without EGF stimulation and reduced motility and invasiveness in vitro and in vivo. Collaboratively, these results demonstrate that sennoside A is a novel inhibitor of SSHs and suggest that it may be valuable in the development of pharmaceutical drugs for treating cancer metastasis.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Movimento Celular/efeitos dos fármacos
Invasividade Neoplásica/prevenção & controle
Neoplasias Pancreáticas/tratamento farmacológico
Fosfoproteínas Fosfatases/antagonistas & inibidores
Fosfoproteínas Fosfatases/metabolismo
Extrato de Sena/farmacologia
[Mh] Termos MeSH secundário: Fatores de Despolimerização de Actina/metabolismo
Actinas/metabolismo
Linhagem Celular Tumoral
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Invasividade Neoplásica/patologia
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
Neoplasias Pancreáticas/metabolismo
Neoplasias Pancreáticas/patologia
Fosforilação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Actin Depolymerizing Factors); 0 (Actins); 0 (Antineoplastic Agents); 8013-11-4 (Senna Extract); 9VK7V8762D (sennoside A&B); EC 3.1.3.16 (Phosphoprotein Phosphatases); EC 3.1.3.16 (SSH1 protein, human)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:27987136
[Au] Autor:Prasad VG; Abraham P
[Ad] Endereço:VGM Hospital, 2100, Trichy Road, Coimbatore, 641 005, India. drvgm@rediffmail.com.
[Ti] Título:Management of chronic constipation in patients with diabetes mellitus.
[So] Source:Indian J Gastroenterol;36(1):11-22, 2017 Jan.
[Is] ISSN:0975-0711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:AIM: The aim of this review is to provide an overview of the clinical assessment and evidence-based treatment options for managing diabetes-associated chronic constipation. METHODS: A literature search of published medical reports in English language was performed using the OVID Portal, from PUBMED and the Cochrane Database of Systematic Reviews, from inception to October 2015. A total of 145 abstracts were identified; duplicate publications were removed and 95 relevant full-text articles were retrieved for potential inclusion. RESULTS: Chronic constipation is one of the most common gastrointestinal symptoms in patients with diabetes, and occurs more frequently than in healthy individuals. Treatment goals include improving symptoms and restoring bowel function by accelerating colonic transit and facilitating defecation. Based on guidelines and data from published literature, food and dietary change with exercise and lifestyle change should be the first step in management. For patients recalcitrant to these changes, laxatives should be the next step of treatment. Treatment should begin with bulking agents such as psyllium, bran or methylcellulose followed by osmotic laxatives if response is poor. Lactulose, polyethylene glycol and lactitol are the most frequently prescribed osmotic agents. Lactulose has a prebiotic effect and a carry-over effect (continued laxative effect for at least 6 to 7 days, post cessation of treatment). Stimulants such as bisacodyl, sodium picosulphate and senna are indicated if osmotic laxatives are not effective. Newer agents such as chloride-channel activators and 5-HT4 agonist can be considered for severe or resistant cases. CONCLUSION: The primary aim of intervention in diabetic patients with chronic constipation is to better manage the diabetes along with management of constipation. The physician should explain the rationale for prescribing laxatives and educate patients about the potential drawbacks of long-term use of laxatives. They should contact their physician if short-term use of prescribed laxative fails to provide relief.
[Mh] Termos MeSH primário: Constipação Intestinal/etiologia
Constipação Intestinal/terapia
Complicações do Diabetes/complicações
[Mh] Termos MeSH secundário: Bisacodil/administração & dosagem
Agonistas dos Canais de Cloreto/administração & dosagem
Doença Crônica
Citratos/administração & dosagem
Fibras na Dieta/administração & dosagem
Medicina Baseada em Evidências
Terapia por Exercício
Estilo de Vida Saudável
Seres Humanos
Laxantes/administração & dosagem
Metilcelulose/administração & dosagem
Compostos Organometálicos/administração & dosagem
Picolinas/administração & dosagem
Psyllium/administração & dosagem
Extrato de Sena/administração & dosagem
Agonistas de Receptores 5-HT4 de Serotonina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chloride Channel Agonists); 0 (Citrates); 0 (Dietary Fiber); 0 (Laxatives); 0 (Organometallic Compounds); 0 (Picolines); 0 (Serotonin 5-HT4 Receptor Agonists); 10X0709Y6I (Bisacodyl); 8013-11-4 (Senna Extract); 8063-16-9 (Psyllium); 9004-67-5 (Methylcellulose); LR57574HN8 (picosulfate sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE
[do] DOI:10.1007/s12664-016-0724-2


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[PMID]:27855501
[Au] Autor:Dhanani T; Singh R; Reddy N; Trivedi A; Kumar S
[Ad] Endereço:a Directorate of Medicinal and Aromatic Plants Research (Indian Council of Agricultural Research) , Anand , India.
[Ti] Título:Comparison on extraction yield of sennoside A and sennoside B from senna (Cassia angustifolia) using conventional and non conventional extraction techniques and their quantification using a validated HPLC-PDA detection method.
[So] Source:Nat Prod Res;31(9):1097-1101, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Senna is an important medicinal plant and is used in many Ayurvedic formulations. Dianthraquinone glucosides are the main bioactive phytochemicals present in leaves and pods of senna. The extraction efficiency in terms of yield and composition of the extract of senna prepared using both conventional (cold percolation at room temperature and refluxing) and non conventional (ultrasound and microwave assisted solvent extraction as well as supercritical fluid extraction) techniques were compared in the present study. Also a rapid reverse phase HPLC-PDA detection method was developed and validated for the simultaneous determination of sennoside A and sennoside B in the different extracts of senna leaves. Ultrasound and microwave assisted solvent extraction techniques were more effective in terms of yield and composition of the extracts compared to cold percolation at room temperature and refluxing methods of extraction.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Extrato de Sena/isolamento & purificação
Senna (Planta)/química
[Mh] Termos MeSH secundário: Cromatografia de Fase Reversa
Cromatografia com Fluido Supercrítico
Folhas de Planta/química
Extrato de Sena/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
8013-11-4 (Senna Extract); 9VK7V8762D (sennoside A&B)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1258562


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[PMID]:27836356
[Au] Autor:Santos-Jasso KA; Arredondo-García JL; Maza-Vallejos J; Lezama-Del Valle P
[Ad] Endereço:Department of General Pediatric Surgery, Instituto Nacional de Pediatría, Ciudad de México, Mexico 04530. Electronic address: santosjasso@hotmail.com.
[Ti] Título:Effectiveness of senna vs polyethylene glycol as laxative therapy in children with constipation related to anorectal malformation.
[So] Source:J Pediatr Surg;52(1):84-88, 2017 Jan.
[Is] ISSN:1531-5037
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Constipation is present in 80% of children with corrected anorectal malformations, usually associated to rectal dilation and hypomotility. Osmotic laxatives are routinely used for idiopathic constipation. Senna is a stimulant laxative that produces contractions improving colonic motility without affecting the stool consistency. We designed this trial to study the effectiveness of Senna versus polyethylene glycol for the treatment of constipation in children with anorectal malformation. METHODS: A randomized controlled crossover design clinical trial, including a washout period, was conducted, including children with corrected anorectal malformations with fecal continence and constipation. The sample size was calculated for proportions (n=28) according to available data for Senna. Effectiveness of laxative therapy was measured with a three variable construct: 1) daily bowel movement, 2) fecal soiling, 3) a "clean" abdominal x-ray. Data analysis included descriptive statistics and a Fisher's exact test for the outcome variable (effectiveness). RESULTS: The study was terminated early because the interim analysis showed a clear benefit toward Senna (p = 0.026). The sample showed a normal statistical distribution for the variables age and presence of megarectum. The maximum daily dose of Senna (sennosides A and B) was 38.7mg and 17g for polyethylene glycol. No adverse effects were identified. CONCLUSION: Therapy with Senna should be the laxative treatment of choice as part of a bowel management program in children with repaired anorectal malformations and constipation, since the stimulation of colonic propulsion waves could lead to stool evacuation without modification of its consistency which can affect fecal continence. LEVEL OF EVIDENCE: I - randomized controlled trial with adequate statistical power.
[Mh] Termos MeSH primário: Malformações Anorretais/complicações
Catárticos/uso terapêutico
Constipação Intestinal/tratamento farmacológico
Laxantes/uso terapêutico
Polietilenoglicóis/uso terapêutico
Extrato de Sena/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Constipação Intestinal/etiologia
Estudos Cross-Over
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cathartics); 0 (Laxatives); 30IQX730WE (Polyethylene Glycols); 8013-11-4 (Senna Extract); 9VK7V8762D (sennoside A&B)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE


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[PMID]:27830982
[Au] Autor:Yin Z; Sun L; Jin Q; Song S; Feng Y; Liao H; Ni Y; Zhang J; Liu W
[Ad] Endereço:a Department of Natural Medicinal Chemistry & Jiangsu Key Laboratory of Drug Screening , China Pharmaceutical University , Nanjing , Jiangsu Province , P.R. China.
[Ti] Título:Excretion and toxicity evaluation of I-Sennoside A as a necrosis-avid agent.
[So] Source:Xenobiotica;47(11):980-988, 2017 Nov.
[Is] ISSN:1366-5928
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. Sennoside A (SA) is a newly identified necrosis-avid agent that shows capability for imaging diagnosis and tumor necrosis targeted radiotherapy. As a water-soluble compound, I-Sennoside A ( I-SA) might be excreted predominately through the kidneys with the possibility of nephrotoxicity. 2. To further verify excretion pathway and examine nephrotoxicity of I-SA, excretion and nephrotoxicity were appraised. The pharmacokinetics, hepatotoxicity and hematotoxicity of I-SA were also evaluated to accelerate its possible clinical translation. All these studies were conducted in mice with ethanol-induced muscular necrosis following a single intravenous administration of 131I-SA at 18.5 MBq/kg or 370 MBq/kg. 3. Excretion data revealed that I-SA was predominately (73.5% of the injected dose (% ID)) excreted via the kidneys with 69.5% ID detected in urine within 72 h post injection. Biodistribution study indicated that I-SA exhibited initial high distribution in the kidneys but subsequently a fast renal clearance, which was further confirmed by the results of autoradiography and single-photon emission computed tomography-computed tomography (SPECT-CT) imaging. The maximum necrotic to normal muscle ratio reached to 7.9-fold at 48 h post injection, which further verified the necrosis avidity of I-SA. Pharmacokinetic parameters showed that I-SA had fast blood clearance with an elimination half-life of 6.7 h. Various functional indexes were no significant difference (p > 0.05) between before administration and 1 d, 8 d, 16 d after administration. Histopathology showed no signs of tissue damage. 4. These data suggest I-SA is a safe and promising necrosis-avid agent applicable in imaging diagnosis and tumor necrosis targeted radiotherapy.
[Mh] Termos MeSH primário: Radioisótopos do Iodo/toxicidade
Compostos Radiofarmacêuticos/toxicidade
Extrato de Sena/toxicidade
[Mh] Termos MeSH secundário: Animais
Radioisótopos do Iodo/metabolismo
Camundongos
Necrose
Compostos Radiofarmacêuticos/metabolismo
Extrato de Sena/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Iodine Radioisotopes); 0 (Radiopharmaceuticals); 8013-11-4 (Senna Extract); 9VK7V8762D (sennoside A&B)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161111
[St] Status:MEDLINE
[do] DOI:10.1080/00498254.2016.1258740


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[PMID]:27355265
[Au] Autor:Okuda Y; Taura K; Yoshino K; Ikeno Y; Nishio T; Yamamoto G; Tanabe K; Koyama Y; Hatano E; Tanaka S; Uemoto S
[Ad] Endereço:*Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan †Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
[Ti] Título:Usefulness of Mac-2 Binding Protein Glycosylation Isomer for Prediction of Posthepatectomy Liver Failure in Patients With Hepatocellular Carcinoma.
[So] Source:Ann Surg;265(6):1201-1208, 2017 Jun.
[Is] ISSN:1528-1140
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to evaluate the usefulness of the Mac-2 binding protein glycosylation isomer (M2BPGi) for the prediction of posthepatectomy liver failure (PHLF) in hepatocellular carcinoma (HCC) patients. SUMMARY BACKGROUND DATA: M2BPGi is a novel serum marker of liver fibrosis. The usefulness of M2BPGi for the prediction of PHLF has not been evaluated. METHODS: Clinicopathological data were analyzed in 138 HCC patients who underwent liver resection between August 2011 and November 2014. PHLF was evaluated according to the definition of the International Study Group of Liver Surgery. Performance of preoperative parameters in predicting PHLF was determined using receiver operating characteristic (ROC) analysis. RESULTS: Serum M2BPGi level correlated with the METAVIR fibrosis score. M2BPGi levels of hepatitis C virus (HCV)-positive patients were significantly higher than those of HCV-negative patients, even in the same fibrosis stage. PHLF ≥ Grade B developed in 19 patients (13.8%). The area under the ROC curve (AUROC) of M2BPGi for the prediction of PHLF ≥ Grade B was 0.71. In multivariate analysis, M2BPGi [odds ratio (OR): 2.08, 95% confidence interval (CI) 1.28-3.55], platelet count (OR: 0.39, 95% CI 0.18-0.80), and resection rate (OR: 2.71, 95% CI 1.46-5.40) were the significant factors associated with PHLF ≥ Grade B. The AUROC of the PHLF index defined by these factors was 0.81. Notably, in patients with HCV infection, the predictive ability of M2BPGi for PHLF (AUROC 0.85) was the best among the preoperative parameters. CONCLUSIONS: M2BPGi is a useful predictor of PHLF, especially in patients with HCV infection.
[Mh] Termos MeSH primário: Antígenos de Neoplasias/sangue
Carcinoma Hepatocelular/cirurgia
Hepatectomia/efeitos adversos
Falência Hepática/diagnóstico
Neoplasias Hepáticas/cirurgia
Glicoproteínas de Membrana/sangue
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Biomarcadores/sangue
Combinação de Medicamentos
Feminino
Glicosilação
Seres Humanos
Cirrose Hepática/diagnóstico
Masculino
Meia-Idade
Psyllium
Estudos Retrospectivos
Extrato de Sena
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Neoplasm); 0 (Biomarkers); 0 (Drug Combinations); 0 (Membrane Glycoproteins); 0 (Perdiem); 0 (TAA90K protein, human); 8013-11-4 (Senna Extract); 8063-16-9 (Psyllium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170720
[Lr] Data última revisão:
170720
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160630
[St] Status:MEDLINE
[do] DOI:10.1097/SLA.0000000000001836


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[PMID]:28480375
[Au] Autor:P J; P F A; B A; T A; R N; D K
[Ad] Endereço:Department of Biological Sciences, School of Science, Eldoret University, Kenya.
[Ti] Título: ANTIFUNGAL ACTIVITY OF METHANOLIC EXTRACTS OF DIFFERENT (FRESEN.) H.S. IRWIN & BARNEBY PLANT PARTS.
[So] Source:Afr J Tradit Complement Altern Med;13(6):168-174, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Herbal medicines have been in use for many years and remain widespread in developing countries; whereas, the use of complementary alternative medicine is on the increase in developed countries. is important for its medicinal benefits among most communities in treating a wide range of ailments. MATERIALS AND METHODS: Plants were collected from a cluster in Siaya, Nandi and Nakuru counties (Kenya). Stem bark, root bark, leaves, flowers and immature pods were obtained; air-dried and ground into fine powder. Methanol was used to extract the plant extracts. The extracts were reconstituted in water and incorporated into growth media to obtain 0%, 2.5%, 5%, 7.5% and 10%. Bioassays were carried out on (ATCC 28942) and (14053). The growth of cultures on the plates was measured over a period of sixteen days. The area under disease progress stairs was determined and subjected to ANOVA and comparison of means using LSD. RESULTS: Results indicated that the growth of was not significantly affected by the plant extracts. Growth of was completely inhibited by immature pods extract at 10%, the leaves and flowers extracts inhibited the growth at 7.5%. The stem and root bark extracts inhibited growth at low dosages of 2.5- 5 %. CONCLUSION: There is need to carry out research on root and stem barks to identify the active phytochemicals that contribute to their high efficacies. On species conservation, harvesting of roots may lead to depletion of .
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Cassia/química
Metanol/farmacologia
Componentes Aéreos da Planta/química
Extrato de Sena/farmacologia
[Mh] Termos MeSH secundário: Candida albicans/efeitos dos fármacos
Quênia
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 8013-11-4 (Senna Extract); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.24


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[PMID]:28076934
[Au] Autor:Dong Y; Yang C; Wang Z; Qin Z; Cao J; Chen Y
[Ad] Endereço:China Agricultural University. ylbcdong@cau.edu.cn.
[Ti] Título:The injury of serotonin on intestinal epithelium cell renewal of weaned diarrhoea mice.
[So] Source:Eur J Histochem;60(4):2689, 2016 Dec 28.
[Is] ISSN:2038-8306
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Diarrhoea is a common cause of death in children and weaned animals. Recent research has found that serotonin (5-HT) in the gastrointestinal tract plays an important role in regulating growth and the maintenance of mucosa, which protect against diarrhoea. To determine the influence of 5-HT on intestinal epithelium cell renewal under weaned stress diarrhoea, a weaned-stress diarrhoea mouse model was established with senna infusion (15 mL/Kg) via intragastric administration and stress restraint (SR). Mice with an increase in 5-HT were induced by intraperitoneal injection with citalopram hydrobromide (CH, 10 mg/Kg). The results demonstrated that compared with the control animals, diarrhoea appeared in weaned stress mice and the 5-HT content in the small intestine was significantly increased (P<0.05). Further, the caspase-3 cells and cells undergoing apoptosis in the small intestine were significantly increased, but the VH (villus height), V/C (villus height /crypt depth), and PCNA-positive rate significantly decreased. Compared with the control animals, CH increased the intestinal 5-HT content, caspase-3 cells and cells undergoing apoptosis but decreased the VH and V/C. Compared with both control and weaned stress animals, weaned stress animals that were pre-treated with CH showed higher 5-HT concentrations, positive caspase-3 cells and cells undergoing apoptosis but lower VH, V/C and PCNA-positive rate. In vitro, a low concentration of 5-HT inhibit, IEC-6 cell line apoptosis but a higher concentration of 5-HT promoted it. Therefore, weaned stress diarrhoea mice were accompanied by a 5-HT increase in the small intestine and vice versa, and the increase in 5-HT induced by CH caused diarrhoea. In brief, 5-HT and diarrhoea slowed the intestinal epithelium cell renewal and injured the abortion function and mucosal barrier by decreasing VH, V/C and proliferation and increasing epithelium cell apoptosis.
[Mh] Termos MeSH primário: Diarreia/metabolismo
Mucosa Intestinal/lesões
Mucosa Intestinal/metabolismo
Intestino Delgado/lesões
Intestino Delgado/metabolismo
Serotonina/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Diarreia/induzido quimicamente
Diarreia/patologia
Modelos Animais de Doenças
Mucosa Intestinal/patologia
Intestino Delgado/patologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Extrato de Sena/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
333DO1RDJY (Serotonin); 8013-11-4 (Senna Extract)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170416
[Lr] Data última revisão:
170416
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.4081/ejh.2016.2689



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