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[PMID]:28388409
[Au] Autor:Yang Y; Liu B; Xu J; Wang J; Wu J; Shi C; Xu Y; Dong J; Wang C; Lai W; Zhu J; Xiong L; Zhu D; Li X; Yang W; Yamauchi T; Sugawara A; Li Z; Sun F; Li X; Li C; He A; Du Y; Wang T; Zhao C; Li H; Chi X; Zhang H; Liu Y; Li C; Duo S; Yin M; Shen H; Belmonte JC; Deng H
[Ad] Endereço:Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Pek
[Ti] Título:Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
[So] Source:Cell;169(2):243-257.e25, 2017 Apr 06.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of developmental potency and are characterized by their ability to generate all cell types of an adult organism. However, PSCs show limited contribution to the extraembryonic placental tissues in vivo. Here, we show that a chemical cocktail enables the derivation of stem cells with unique functional and molecular features from mice and humans, designated as extended pluripotent stem (EPS) cells, which are capable of chimerizing both embryonic and extraembryonic tissues. Notably, a single mouse EPS cell shows widespread chimeric contribution to both embryonic and extraembryonic lineages in vivo and permits generating single-EPS-cell-derived mice by tetraploid complementation. Furthermore, human EPS cells exhibit interspecies chimeric competency in mouse conceptuses. Our findings constitute a first step toward capturing pluripotent stem cells with extraembryonic developmental potentials in culture and open new avenues for basic and translational research. VIDEO ABSTRACT.
[Mh] Termos MeSH primário: Técnicas de Cultura de Células/métodos
Células-Tronco Pluripotentes/citologia
[Mh] Termos MeSH secundário: Animais
Blastocisto/citologia
Linhagem Celular
Quimera/metabolismo
Dimetideno/farmacologia
Seres Humanos
Indicadores e Reagentes/química
Camundongos
Minociclina/química
Minociclina/farmacologia
Células-Tronco Pluripotentes/efeitos dos fármacos
Poli(ADP-Ribose) Polimerase-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indicators and Reagents); 661FH77Z3P (Dimethindene); EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1); FYY3R43WGO (Minocycline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE


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[PMID]:27335428
[Au] Autor:De Bruyne P; Christiaens T; Boussery K; Mehuys E; Van Winckel M
[Ad] Endereço:Department of Paediatrics and Medical Genetics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
[Ti] Título:Are antihistamines effective in children? A review of the evidence.
[So] Source:Arch Dis Child;102(1):56-60, 2017 Jan.
[Is] ISSN:1468-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: During the last decades, much attention has been paid to off-label and unlicensed prescriptions in paediatrics. However, on-label prescribing can also cause health issues. In this paper, the case of first-generation H -antihistamines is investigated, notably the range of indications for which products are licensed in different European countries and the evidence base (or lack thereof) for each indication, as well as reported adverse drug reactions. METHODS: Review of the Summary of Product Characteristics of first-generation H -antihistamines with a focus on paediatric use. This is plotted against the evidence available in the literature. RESULTS: This investigation shows a large variability in labelled indications and licensing ages when compared in five different European countries. Moreover, most of the indications are not based on clinical trials evaluating efficacy and safety of these drugs in children. CONCLUSIONS: Many of the licensed indications of first-generation antihistamines do not appear to be evidence based.
[Mh] Termos MeSH primário: Antagonistas dos Receptores Histamínicos/uso terapêutico
[Mh] Termos MeSH secundário: Criança
Ciproeptadina/uso terapêutico
Dimetideno/uso terapêutico
Aprovação de Drogas
Rotulagem de Medicamentos
Medicina Baseada em Evidências
Seres Humanos
Uso Off-Label
Resultado do Tratamento
Trimeprazina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Histamine Antagonists); 2YHB6175DO (Cyproheptadine); 661FH77Z3P (Dimethindene); 76H78MJJ52 (Trimeprazine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160624
[St] Status:MEDLINE
[do] DOI:10.1136/archdischild-2015-310416


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[PMID]:25359709
[Au] Autor:Kyriakidis K; Zampeli E; Palaiologou M; Tiniakos D; Tiligada E
[Ad] Endereço:Department of Pharmacology, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece.
[Ti] Título:Histamine H3 and H4 receptor ligands modify vascular histamine levels in normal and arthritic large blood vessels in vivo.
[So] Source:Inflammation;38(3):949-58, 2015.
[Is] ISSN:1573-2576
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Growing evidence associates histamine with arthritis, but its implication in shaping vascular function in chronic inflammation remains largely elusive. This study explored the involvement of vascular histamine in the extra-articular responses in peripheral large blood vessels using a rat model of adjuvant-induced arthritis. Histamine levels were increased in the abdominal aorta and the inferior vena cava of arthritic animals. Contrary to the H1 receptor antagonist dimetindene, histamine induction was observed following administration of the H3 and H4 receptor ligands GSK334429 and JNJ7777120, respectively. In arthritis, prophylactic treatment with GSK334429 partially attenuated the clinical signs and restored basal histamine levels only in the abdominal aorta. This study is the first to implicate the H3 and H4 receptors in a concerted constitutive regulation of basal vascular histamine in the rat large blood vessels and to identify the H3 receptor as a component that may influence arterial histamine during the onset of arthritis.
[Mh] Termos MeSH primário: Aorta/patologia
Artrite Experimental/patologia
Receptores Acoplados a Proteínas-G/metabolismo
Receptores Histamínicos H3/metabolismo
Receptores Histamínicos/metabolismo
Veia Cava Inferior/patologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Azepinas/uso terapêutico
Dimetideno/uso terapêutico
Endotélio/metabolismo
Adjuvante de Freund
Histamina/sangue
Histamina/metabolismo
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Antagonistas dos Receptores Histamínicos H3/uso terapêutico
Indóis/uso terapêutico
Inflamação/patologia
Masculino
Piperazinas/uso terapêutico
Piridinas/uso terapêutico
Ratos
Ratos Wistar
Receptores Histamínicos H4
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine); 0 (1-(1-methylethyl)-4-((1-(6-(trifluoromethyl)-3-pyridinyl)-4-piperidinyl)carbonyl)hexahydro-1H-1,4-diazepine); 0 (Anti-Inflammatory Agents); 0 (Azepines); 0 (Histamine H1 Antagonists); 0 (Histamine H3 Antagonists); 0 (Hrh4 protein, rat); 0 (Indoles); 0 (Piperazines); 0 (Pyridines); 0 (Receptors, G-Protein-Coupled); 0 (Receptors, Histamine); 0 (Receptors, Histamine H3); 0 (Receptors, Histamine H4); 661FH77Z3P (Dimethindene); 820484N8I3 (Histamine); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141101
[St] Status:MEDLINE
[do] DOI:10.1007/s10753-014-0057-1


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[PMID]:25238447
[Au] Autor:Peckruhn M; Tittelbach J; Schliemann S; Elsner P
[Ad] Endereço:Department of Dermatology, University Hospital Jena, Jena, Germany.
[Ti] Título:Life of lesions in eosinophilic cellulitis (Wells' syndrome)-a condition that may be missed at first sight.
[So] Source:Am J Dermatopathol;37(2):e15-7, 2015 Feb.
[Is] ISSN:1533-0311
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eosinophilic cellulitis is an inflammation of, until now, unknown etiology that was first described by George Wells in 1971. Its dominating histological hallmarks are so-called "flame figures" and an eosinophilic infiltrate. Here, we report the case of a 46-year-old man who initially presented with excoriated papules that were histologically interpreted as consistent with "arthropod reactions." Later on, the clinical presentation changed to erythematous plaques, partially with cockade-like aspects. At this time, new biopsies were performed showing a superficial and deep perivascular lymphocytic and heavily eosinophilic infiltrate and flame figures, thus allowing to establish the diagnosis of Wells' syndrome. Under treatment with oral prednisolone and dapsone, the patient showed a rapid improvement of the condition. The presented case demonstrates both the clinical and histopathologic life of lesions of Well's syndrome in the course of the disease from unspecific to distinctive. The need for repeated biopsies is discussed. Current understanding of the pathogenesis of Wells' syndrome and its correlating histological features are elucidated.
[Mh] Termos MeSH primário: Celulite (Flegmão)/diagnóstico
Erros de Diagnóstico
Eosinofilia/diagnóstico
Pele/patologia
[Mh] Termos MeSH secundário: Administração Oral
Antipruriginosos/uso terapêutico
Biópsia
Celulite (Flegmão)/tratamento farmacológico
Celulite (Flegmão)/patologia
Dapsona/administração & dosagem
Dimetideno/administração & dosagem
Quimioterapia Combinada
Eosinofilia/tratamento farmacológico
Eosinofilia/patologia
Glucocorticoides/administração & dosagem
Seres Humanos
Masculino
Meia-Idade
Valor Preditivo dos Testes
Prednisolona/administração & dosagem
Pele/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipruritics); 0 (Glucocorticoids); 661FH77Z3P (Dimethindene); 8W5C518302 (Dapsone); 9PHQ9Y1OLM (Prednisolone)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:150122
[Lr] Data última revisão:
150122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140920
[St] Status:MEDLINE
[do] DOI:10.1097/DAD.0000000000000051


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[PMID]:24383318
[Au] Autor:Wyszomirska E; Czerwinska K; Kublin E; Mazurek AP
[Ad] Endereço:Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chelmska St. 00-725 Warszawa, Poland. ewyszomirska@il.waw.pl
[Ti] Título:Identification and determination of ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method.
[So] Source:Acta Pol Pharm;70(6):951-9, 2013 Nov-Dec.
[Is] ISSN:0001-6837
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals were provided. Maximum wavelenghts were: 228 nm for ketotifen hydrogen fumarate, 295 nm for azelastine hydrochloride, 265 nm for dimetindene maleate and 255 nm for promethazine hydrochloride. The limits of quantification were in the ranges of 0.2-5 microg/spot. The statistical data showed adequate accuracy and precision of developed methods.
[Mh] Termos MeSH primário: Cromatografia em Camada Delgada
Densitometria
Dimetideno/análise
Antagonistas dos Receptores Histamínicos H1/análise
Ftalazinas/análise
Prometazina/análise
[Mh] Termos MeSH secundário: Calibragem
Cromatografia em Camada Delgada/normas
Densitometria/normas
Cetotifeno/análise
Limite de Detecção
Análise de Regressão
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine H1 Antagonists); 0 (Phthalazines); 661FH77Z3P (Dimethindene); FF28EJQ494 (Promethazine); X49220T18G (Ketotifen); ZQI909440X (azelastine)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:140103
[Lr] Data última revisão:
140103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140104
[St] Status:MEDLINE


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[PMID]:24114734
[Au] Autor:Eichenseer M; Johansen C; Mueller RS
[Ad] Endereço:Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig Maximilian University Munich, Munich 80539, Germany.
[Ti] Título:Efficacy of dimetinden and hydroxyzine/chlorpheniramine in atopic dogs: a randomised, controlled, double-blinded trial.
[So] Source:Vet Rec;173(17):423, 2013 Nov 02.
[Is] ISSN:2042-7670
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antihistaminic drugs are commonly used as symptomatic therapy of atopic dermatitis in dogs. Unfortunately, their clinical benefit is largely unsubstantiated. In a double-blinded, placebo-controlled, cross-over trial, the influence of dimetinden and of a combination of chlorpheniramine and hydroxyzine on pruritus and lesions was evaluated in 19 dogs. They were treated with either product or a placebo orally for 14 days, each time followed by a 14-day washout period. Before and after each period, the dogs were examined and the Canine Atopic Dermatitis Extent and Severity Index (CADESI) determined by a clinician, and the pruritus and general condition by the owner. Dimetinden improved the pruritus significantly (P=0.014) but not the CADESI (P=0.087), the combination of hydroxyzine and chlorpheniramine improved the CADESI (P=0.049) and pruritus (P=0.05) significantly. Ten of 17 dogs improved by more than 25 per cent in pruritus with the combination of hydroxyzine and chlorpheniramine, 12 of 18 with dimetindenmaleate and only 2 of 19 with placebo. Antihistamines can help to reduce pruritus in atopic dogs, but in most cases, the improvement is limited and additional treatment may be needed.
[Mh] Termos MeSH primário: Antipruriginosos/uso terapêutico
Clorfeniramina/uso terapêutico
Dermatite Atópica/veterinária
Dimetideno/uso terapêutico
Doenças do Cão/tratamento farmacológico
Hidroxizina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Estudos Cross-Over
Dermatite Atópica/tratamento farmacológico
Cães
Método Duplo-Cego
Quimioterapia Combinada/veterinária
Feminino
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipruritics); 30S50YM8OG (Hydroxyzine); 3U6IO1965U (Chlorpheniramine); 661FH77Z3P (Dimethindene)
[Em] Mês de entrada:1402
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131012
[St] Status:MEDLINE
[do] DOI:10.1136/vr.101907


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[PMID]:23514055
[Au] Autor:Christodoulidis G; Tsilioni I; Spyridakis ME; Kiropoulos T; Oikonomidi S; Koukoulis G; Tepetes K
[Ad] Endereço:General Surgery Department, University Hospital of Larissa, Larissa, Greece. gregsurg@yahoo.gr
[Ti] Título:Matrix metaloproteinase-2 and -9 serum levels as potential markers of intraperitoneal adhesions.
[So] Source:J Invest Surg;26(3):134-40, 2013 Jun.
[Is] ISSN:1521-0553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the value of matrix metalloproteinases-2 (MMP-2) and -9 (MMP-9) as prognostic serum markers for intraperitoneal adhesions. BACKGROUND: Postoperative adhesions are associated with serious complications responsible for increased patient's morbidity. METHODS: Forty-eight rabbits were used and randomized into groups A, B, C, and D. Abdominal laparotomy and experimental adhesion formation model was carried out. In group A, 60 mL of N/S 0.9% were instilled intraperitoneally, in group B 60 mL of icodextrin 4% were instilled intraperitoneally, in group C 0.1 mL/kg of dimetindene maleate were administered intravenously, and in group D both agents were administered. Prior to euthanasia 0.5 mL of blood was obtained. The type, the surface area of adhesions, and serum concentration of MMPs were assessed. RESULTS: The mean surface area and Zuhlke classification of adhesions of groups B, C, and D has been proved to be significantly lower compared to group A. Serum MMP-2 levels were significantly higher in groups B and D than in group A, while group D was higher when compared to group C. Serum MMP-9 levels were significantly higher in group D compared to groups A, B, and C. Serum MMP-9 was the most accurate test to differentiate between animals with and without adhesions with a sensitivity of 81.8% and a specificity of 100% at a cut-off point of 21.5 (AUC = 0.934). CONCLUSIONS: The administration of icodextrin 4% and dimetindene maleate seems to prevent postoperative adhesion formation. Serum levels of MMP-2 and MMP-9 may serve as prognostic markers to identify postoperative adhesions.
[Mh] Termos MeSH primário: Biomarcadores/sangue
Dimetideno/uso terapêutico
Glucanos/uso terapêutico
Glucose/uso terapêutico
Metaloproteinase 2 da Matriz/sangue
Metaloproteinase 9 da Matriz/sangue
Doenças Peritoneais/prevenção & controle
Complicações Pós-Operatórias/diagnóstico
[Mh] Termos MeSH secundário: Animais
Feminino
Doenças Peritoneais/sangue
Doenças Peritoneais/patologia
Prognóstico
Coelhos
Aderências Teciduais/sangue
Aderências Teciduais/patologia
Aderências Teciduais/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Glucans); 2NX48Z0A9G (icodextrin); 661FH77Z3P (Dimethindene); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1312
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130322
[St] Status:MEDLINE
[do] DOI:10.3109/08941939.2012.730599


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[PMID]:21349079
[Au] Autor:Gruber R; Vassilaki I; Zelger B
[Ad] Endereço:Department of Dermatology, Innsbruck Medical University, Innsbruck, Austria. r.gruber@i-med.ac.at
[Ti] Título:Concomitant juvenile xanthogranuloma and cutaneous mastocytosis in a 3-year-old Swedish girl: case report and review of the literature.
[So] Source:Int J Dermatol;50(5):611-4, 2011 May.
[Is] ISSN:1365-4632
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Mastocitose Cutânea/patologia
Xantogranuloma Juvenil/patologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Biópsia
Pré-Escolar
Dimetideno/uso terapêutico
Feminino
Antagonistas dos Receptores Histamínicos H1/uso terapêutico
Seres Humanos
Cetotifeno/uso terapêutico
Mastocitose Cutânea/complicações
Mastocitose Cutânea/tratamento farmacológico
Prurido/diagnóstico
Prurido/tratamento farmacológico
Resultado do Tratamento
Xantogranuloma Juvenil/complicações
Xantogranuloma Juvenil/tratamento farmacológico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Histamine H1 Antagonists); 661FH77Z3P (Dimethindene); X49220T18G (Ketotifen)
[Em] Mês de entrada:1108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110226
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-4632.2010.04553.x


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[PMID]:21272026
[Au] Autor:Leroy A; Baeck M; Tennstedt D
[Ad] Endereço:Department of Dermatology, Cliniques Universitaires Saint Luc, B-1200 Brussels, Belgium. alice.leroy@uclouvain.be
[Ti] Título:Contact dermatitis and secondary systemic allergy to dimethindene maleate.
[So] Source:Contact Dermatitis;64(3):170-1, 2011 Mar.
[Is] ISSN:1600-0536
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Dermatite Alérgica de Contato/etiologia
Dimetideno/efeitos adversos
Antagonistas dos Receptores Histamínicos H1/efeitos adversos
Hipersensibilidade/etiologia
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Criança
Dermatite Alérgica de Contato/tratamento farmacológico
Seres Humanos
Hipersensibilidade/tratamento farmacológico
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Histamine H1 Antagonists); 661FH77Z3P (Dimethindene)
[Em] Mês de entrada:1105
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110129
[St] Status:MEDLINE
[do] DOI:10.1111/j.1600-0536.2010.01830.x


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[PMID]:20881404
[Au] Autor:Kouritas VK; Tepetes K; Christodoulides G; Ioannou M; Spyridakis M; Gourgoulianis KI; Molyvdas PA; Hatzoglou CH
[Ad] Endereço:Department of Surgery, Larissa University Hospital, Larissa, Greece. kouritas @ otenet.gr
[Ti] Título:Permeability alterations after surgical trauma in normal rabbit peritoneum.
[So] Source:Eur Surg Res;45(2):113-9, 2010.
[Is] ISSN:1421-9921
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To investigate whether surgical trauma in a rabbit adhesion formation model and the administration of normal saline (N/S), icodextrin (ID) and/or dimetindene maleate (DM) changes the permeability of the normal rabbit parietal peritoneum. MATERIALS AND METHODS: A total of 45 female rabbits were operated on for adhesion formation and were euthanized 10 days later. In some rabbits, ID or N/S was instilled intraabdominally during operation, whereas in others DM was infused intravenously. In others, ID plus DM or no agent was used. Specimens were obtained postoperatively and were mounted between Ussing chambers. Amiloride was used to investigate Na(+) channels. Transmesothelial resistance (R(TM)) was determined as a permeability indicator. RESULTS: Amiloride increased the R(TM) of both surfaces. Surgical trauma increased R(TM) and partially inhibited the effect of amiloride. ID and N/S increased R(TM) and inhibited the effect of amiloride. Use of DM did not change R(TM) and did not inhibit the effect of amiloride. Use of ID plus DM slightly increased R(TM), but the effect of amiloride was blocked. CONCLUSIONS: Surgical trauma impairs the permeability of the normal rabbit parietal peritoneum. ID or N/S surmounted this effect, but DM did not, suggesting that surgical trauma is a diffuse process. Antiadhesion measures influence peritoneal physiology.
[Mh] Termos MeSH primário: Peritônio/lesões
Peritônio/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Dimetideno/farmacologia
Feminino
Glucanos/farmacologia
Glucose/farmacologia
Peritônio/efeitos dos fármacos
Peritônio/cirurgia
Permeabilidade/efeitos dos fármacos
Coelhos
Aderências Teciduais/etiologia
Aderências Teciduais/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucans); 2NX48Z0A9G (icodextrin); 661FH77Z3P (Dimethindene); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1102
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101001
[St] Status:MEDLINE
[do] DOI:10.1159/000318146



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