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[PMID]:28961484
[Au] Autor:Wang GN; Zhang L; Song YP; Liu JX; Wang JP
[Ad] Endereço:College of Veterinary Medicine, Agricultural University of Hebei, Baoding, Hebei, 071000, China.
[Ti] Título:Application of molecularly imprinted polymer based matrix solid phase dispersion for determination of fluoroquinolones, tetracyclines and sulfonamides in meat.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1065-1066:104-111, 2017 Oct 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this study, a type of novel mixed-template molecularly imprinted polymer was synthesized that was able to recognize 8 fluoroquinolones, 8 sulfonamides and 4 tetracyclines simultaneously with recoveries higher than 92%. Then the polymer was used to develop a matrix solid phase dispersion method for simultaneous extraction of the 20 drugs in pork followed by determination with ultra performance liquid chromatography. During the experiments, the MMIP amount, washing solvent and elution solvent were optimized respectively. The limits of detection of this method for the 20 drugs in pork were in the range of 0.5-3.0ngg , and the intra-day and inter-day recoveries from the fortified blank samples were in the range of 74.5%-102.7%. Therefore, this method could be used as a rapid, simple, specific and sensitive method for multi-determination of the residues of the three classes of drugs in meat.
[Mh] Termos MeSH primário: Fluoroquinolonas/análise
Impressão Molecular/métodos
Carne Vermelha/análise
Extração em Fase Sólida/métodos
Sulfonamidas/análise
Tetraciclinas/análise
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão/métodos
Fluoroquinolonas/química
Fluoroquinolonas/isolamento & purificação
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
Sulfonamidas/química
Sulfonamidas/isolamento & purificação
Suínos
Tetraciclinas/química
Tetraciclinas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoroquinolones); 0 (Sulfonamides); 0 (Tetracyclines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170930
[St] Status:MEDLINE


  2 / 3649 MEDLINE  
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[PMID]:28881459
[Au] Autor:Wagman AS; Cirz R; McEnroe G; Aggen J; Linsell MS; Goldblum AA; Lopez S; Gomez M; Miller G; Simons LJ; Belliotti TR; Harris CR; Poel TJ; Melnick MJ; Gaston RD; Moser HE
[Ad] Endereço:Achaogen, Inc., 1 Tower Place, South San Francisco, CA, 94080, USA.
[Ti] Título:Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones.
[So] Source:ChemMedChem;12(20):1687-1692, 2017 Oct 20.
[Is] ISSN:1860-7187
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Conformationally constrained tetracyclic fluoroquinolones (FQs) were synthesized and profiled for their microbiological spectrum. The installation of a seven-membered ring between the pyrrolidine substituents and the C8 position on the FQ core scaffold resulted in a remarkable enhancement of microbiological potency toward both Gram-positive and Gram-negative bacteria. Focused optimization of seven-membered ring composition, stereochemistry, and amine placement led to the discovery of the two lead compounds that were selected for further progression.
[Mh] Termos MeSH primário: Fluoroquinolonas/síntese química
Fluoroquinolonas/farmacologia
Tetraciclinas/síntese química
Tetraciclinas/farmacologia
[Mh] Termos MeSH secundário: Acinetobacter baumannii/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Pseudomonas aeruginosa/efeitos dos fármacos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoroquinolones); 0 (Tetracyclines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170908
[St] Status:MEDLINE
[do] DOI:10.1002/cmdc.201700426


  3 / 3649 MEDLINE  
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[PMID]:28844300
[Au] Autor:Pei M; Huang X
[Ad] Endereço:State Key Laboratory of Marine Environmental Science, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China.
[Ti] Título:Preparation and evaluation of an adsorbent based on poly (muconic acid-co-divinylbenzene/ethylenedimethacrylate) for multiple monolithic fiber solid-phase microextraction of tetracycline antibiotics.
[So] Source:J Chromatogr A;1517:1-8, 2017 Sep 29.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To extract tetracycline antibiotics (TAs) effectively, a new adsorbent based on poly (muconic acid-co-divinylbenzene/ethylenedimethacrylate) monolith was fabricated and used as the extraction medium of multiple monolithic fiber solid-phase microextraction (MD/MF-SPME). The effect of the fabrication parameters on extraction efficiency was studied thoroughly. Elemental analysis, infrared spectroscopy, scanning electron microscopy and mercury intrusion porosimetry were used to check the physicochemical properties of the adsorbent. Some key parameters that affect the extraction performance of MD/MF-SPME for TAs were investigated systematically. Under the optimized experimental conditions, the prepared adsorbent could effectively extract the TAs through multiple interactions. At the same time, a simple and sensitive method for monitoring trace TAs in honey samples was developed by coupling MD/MF-SPME with high-performance liquid chromatography tandem mass spectrometry detection (MD/MF-SPME-HPLC-MS/MS). The limits of detection (S/N=3) for target compounds were in the range of 7.3-17.1ng/kg. The intra-day and inter-day precision (relative standard deviations, n=4, %) at 0.5µg/kg and 20.0µg/kg spiking concentrations were 5.0-9.5% and 3.6-10.0%, respectively. The mean recoveries of the target TAs in the real honey samples were between 70.5-111.0%.
[Mh] Termos MeSH primário: Análise de Alimentos/métodos
Mel/análise
Metacrilatos/química
Microextração em Fase Sólida/instrumentação
Tetraciclinas/isolamento & purificação
Compostos de Vinila/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Fibras na Dieta/análise
Limite de Detecção
Microscopia Eletrônica de Varredura
Ácido Sórbico/análogos & derivados
Ácido Sórbico/química
Espectrofotometria Infravermelho
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Dietary Fiber); 0 (Methacrylates); 0 (Tetracyclines); 0 (Vinyl Compounds); 3KD92ZL2KH (muconic acid); 7BK5G69305 (ethylene dimethacrylate); IZ715T4SBU (divinyl benzene); X045WJ989B (Sorbic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE


  4 / 3649 MEDLINE  
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[PMID]:28838073
[Au] Autor:Bradshaw CS; Jensen JS; Waites KB
[Ad] Endereço:Central Clinical School, Monash University.
[Ti] Título:New Horizons in Mycoplasma genitalium Treatment.
[So] Source:J Infect Dis;216(suppl_2):S412-S419, 2017 Jul 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mycoplasmagenitalium is an important sexually transmitted pathogen responsible for both male and female genital tract disease. Appreciation of its significance in human disease has been hampered by its slow growth in culture, difficulty in isolating it, and lack of commercial molecular-based tests for rapid detection. Comparatively few in vitro data on antimicrobial susceptibility are available due to the scarcity of clinical isolates and difficulty in performing susceptibility tests to determine minimum inhibitory concentrations for M. genitalium. Antimicrobial agents that inhibit protein synthesis such as macrolides, along with fluoroquinolones that inhibit DNA replication, have been the treatments of choice for M. genitalium infections. Even though international guidelines recommend azithromycin as first-line treatment, rapid spread of macrolide resistance as well as emergence of quinolone resistance has occurred. Increasing rates of treatment failure have resulted in an urgent need for new therapies and renewed interest in other classes such as aminocyclitols, phenicols, and streptogramins as treatment alternatives. Limited data for new investigational antimicrobials such as the ketolide solithromycin suggest that this drug may eventually prove useful in management of some resistant M. genitalium infections, although it is not likely to achieve cure rates >80% in macrolide-resistant strains, in a similar range as recently reported for pristinamycin. However, agents with completely new targets and/or mechanisms that would be less likely to show cross-resistance with currently available drugs may hold the greatest promise. Lefamulin, a pleuromutilin, and new nonquinolone topoisomerase inhibitors are attractive possibilities that require further investigation.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Descoberta de Drogas/classificação
Infecções por Mycoplasma/diagnóstico
Infecções por Mycoplasma/tratamento farmacológico
[Mh] Termos MeSH secundário: Azitromicina/uso terapêutico
Farmacorresistência Bacteriana
Feminino
Fluoroquinolonas/uso terapêutico
Seres Humanos
Masculino
Testes de Sensibilidade Microbiana
Mycoplasma genitalium
Quinolinas/uso terapêutico
Espectinomicina/uso terapêutico
Estreptograminas/uso terapêutico
Tetraciclinas/uso terapêutico
Tianfenicol/uso terapêutico
Falha de Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 0 (Quinolines); 0 (Streptogramins); 0 (Tetracyclines); 83905-01-5 (Azithromycin); 93AKI1U6QF (Spectinomycin); E66400VT9R (quinoline); FLQ7571NPM (Thiamphenicol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix132


  5 / 3649 MEDLINE  
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[PMID]:28802174
[Au] Autor:Gupta VK; Fakhri A; Agarwal S; Ahmadi E; Nejad PA
[Ad] Endereço:Department of Applied Chemistry, University of Johannesburg, Johannesburg, South Africa. Electronic address: vinodfcy@gmail.com.
[Ti] Título:Synthesis and characterization of MnO /NiO nanocomposites for photocatalysis of tetracycline antibiotic and modification with guanidine for carriers of Caffeic acid phenethyl ester-an anticancer drug.
[So] Source:J Photochem Photobiol B;174:235-242, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In the present studies, modified NiO nanoparticles and MnO /NiO nanocomposites with guanidine were synthesized by anchoring method for carriers of anticancer drug "Caffeic acid phenethyl ester". The prepared nanocomposites were characterized by using Scanning Electron Microscopy, Raman and Fourier transform infrared spectroscopy, X-ray diffraction, Vibrating sample magnetometer. The results from XRD indicated that the crystalline size of NiO nanoparticles and MnO /NiO nanocomposites are 12 and 15nm, respectively. Saturation magnetization (Ms) for NiO NPs and MnO /NiO nanocomposites was to be 0.60, and 0.68emu/g indicating that these are superparamagnetic and ferromagnetic properties in nature. The prepared nanocomposites were evaluated as catalyst for degradation of antibiotics in photocatalysis process. Particularly, the MnO /NiO composite demonstrated the higher degradation rate (89.55%) of tetracycline antibiotic under UV light irradiation than the NiO (67.80%). Drug load on and release from nanopowders was investigated by using UV-Vis spectroscopy method. Time of drug loading was 100min and the drug release in 1-10h with 20-80% drug release were found, and then, it's applicable to in-vivo drug delivery. Therefore, the NiO nanoparticles and MnO /NiO nanocomposites are promising for targeted Caffeic acid phenethyl ester anticancer drug delivery applications. The anticancer drug loaded on guanidine-NiO and guanidine-MnO /NiO in high concentration has an antioxidant property.
[Mh] Termos MeSH primário: Ácidos Cafeicos/química
Guanidina/química
Compostos de Manganês/química
Nanocompostos/química
Níquel/química
Óxidos/química
Álcool Feniletílico/análogos & derivados
Fotólise
Tetraciclinas/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Antineoplásicos/química
Catálise
Técnicas de Química Sintética
Portadores de Fármacos/síntese química
Portadores de Fármacos/química
Liberação Controlada de Fármacos
Depuradores de Radicais Livres/síntese química
Depuradores de Radicais Livres/química
Nanopartículas/química
Álcool Feniletílico/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents); 0 (Caffeic Acids); 0 (Drug Carriers); 0 (Free Radical Scavengers); 0 (Manganese Compounds); 0 (Oxides); 0 (Tetracyclines); 059QF0KO0R (Water); 64J2OA7MH3 (manganese oxide); 7OV03QG267 (Nickel); C3574QBZ3Y (nickel monoxide); G960R9S5SK (caffeic acid phenethyl ester); JU58VJ6Y3B (Guanidine); ML9LGA7468 (Phenylethyl Alcohol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170813
[St] Status:MEDLINE


  6 / 3649 MEDLINE  
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[PMID]:28707659
[Au] Autor:Kubanov AA; Leinsoo AT; Chestkov AV; Dementieva EI; Shaskolskiy BL; Solomka VS; Gryadunov DA; Deryabin DG
[Ad] Endereço:State Research Center of Dermatovenerology and Cosmetology, Ministry of Health of Russian Federation, Moscow, 107076 Russia.
[Ti] Título:[Drug resistance mutations and susceptibility phenotypes of Neisseria gonorrhoeae isolates in Russia].
[So] Source:Mol Biol (Mosk);51(3):431-441, 2017 May-Jun.
[Is] ISSN:0026-8984
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Steady growth in the degree of antimicrobial resistance in Neisseria gonorrhoeae calls for the control of the spreading of resistance mutations. Here we present the data describing drug resistance mutations, the results of antimicrobial susceptibility tests, and molecular genotypes of 128 recent N. gonorrhoeae isolates collected across 9 regions of the Russian Federation. The mutations in chromosome genes penA, ponA, rpsJ, gyrA, parC, which determine the susceptibility of N. gonorrhoeae to penicillins, tetracyclines, and fluoroquinolones were detected by multiplex amplification followed by hybridization on a hydrogel microarray. The most frequent mutation was an insertion of an aspartate at position 345 of penA gene (76.6%), whereas mutations Leu421Pro in ponA gene, Val57Met in rpsJ gene, Ser91Phe in gyrA gene, Asp95Gly in gyrA gene, and Ser87Arg in parC gene were detected in 32.8-36.7% of strains. One third of studied N. gonorrhoeae isolates harbored multiple drug resistance mutations in bacterial chromosome, resulting in the bimodal distribution of mutation profiles and related patterns of antimicrobial susceptibility. The spread of multiple resistance could be explained by the vertical transfer of the mutations resulting in the clonality of the N. gonorrhoeae population.
[Mh] Termos MeSH primário: Proteínas de Bactérias/genética
Farmacorresistência Bacteriana/genética
Gonorreia/tratamento farmacológico
Neisseria gonorrhoeae/genética
[Mh] Termos MeSH secundário: Cromossomos Bacterianos/genética
Fluoroquinolonas/uso terapêutico
Genótipo
Gonorreia/genética
Gonorreia/microbiologia
Seres Humanos
Testes de Sensibilidade Microbiana
Mutação
Neisseria gonorrhoeae/efeitos dos fármacos
Neisseria gonorrhoeae/patogenicidade
Penicilinas/uso terapêutico
Fenótipo
Federação Russa
Tetraciclinas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (Fluoroquinolones); 0 (Penicillins); 0 (Tetracyclines)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.7868/S0026898417030119


  7 / 3649 MEDLINE  
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[PMID]:28668369
[Au] Autor:Moreno-González D; Hamed AM; Gilbert-López B; Gámiz-Gracia L; García-Campaña AM
[Ad] Endereço:Analytical Chemistry Research Group, Department Physical and Analytical Chemistry, University of Jaén, 23071 Jaén, Spain; Department Analytical Chemistry, Faculty of Sciences, University of Granada, Campus Fuentenueva s/n, 18071 Granada, Spain.
[Ti] Título:Evaluation of a multiresidue capillary electrophoresis-quadrupole-time-of-flight mass spectrometry method for the determination of antibiotics in milk samples.
[So] Source:J Chromatogr A;1510:100-107, 2017 Aug 11.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A selective and rapid method has been developed to determine 15 antibiotic residues (eight tetracyclines and seven quinolones) in milk samples by capillary zone electrophoresis coupled with quadrupole time-of-flight mass spectrometry (CZE-Q-TOF-MS). The use of this hybrid mass spectrometer allowed obtaining full scan and full MS/MS spectra for quantification/confirmation purposes in a single run. In addition, solid phase extraction (SPE) using the new Oasis PRiME HLB cartridge was proposed for the extraction, achieving excellent results in terms of sample throughput. The proposed method was validated using whole cow milk as representative matrix. Good linearity was obtained (R >0.99) for all the studied compounds. The precision, expressed as relative standard deviation (%, RSD), at two concentration levels (50 and 100µgkg ) was below 13%. Recoveries obtained from goat milk, whole cow milk and semi-skimmed cow milk, at two concentration levels, ranged from 76 to 106%, while limits of quantification ranged from 1.5 to 9.6µgkg , being lower than the established maximum residue limits in the European legislation. Matrix effect was negligible in all cases, showing that with this new SPE sorbent cleanest extracts were obtained with a minimum number of steps in the sample treatment. Thus, the proposed SPE-CZE-Q-TOF-MS method is suitable for multiclass multiresidue monitoring in different types of milk samples.
[Mh] Termos MeSH primário: Antibacterianos/análise
Eletroforese Capilar
Análise de Alimentos/métodos
Leite/química
Espectrometria de Massas em Tandem
[Mh] Termos MeSH secundário: Animais
Bovinos
Eletroforese Capilar/normas
Limite de Detecção
Quinolonas/análise
Reprodutibilidade dos Testes
Extração em Fase Sólida
Espectrometria de Massas em Tandem/normas
Tetraciclinas/análise
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Quinolones); 0 (Tetracyclines)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170703
[St] Status:MEDLINE


  8 / 3649 MEDLINE  
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[PMID]:28664720
[Au] Autor:Marosevic D; Kaevska M; Jaglic Z
[Ad] Endereço:Bavarian Health Food Safety Authority, 85764 Oberschleißheim, Germany. kaevska@vri.cz.
[Ti] Título:Resistance to the tetracyclines and macrolide-lincosamide-streptogramin group of antibiotics and its genetic linkage - a review.
[So] Source:Ann Agric Environ Med;24(2):338-344, 2017 Jun 12.
[Is] ISSN:1898-2263
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:An excessive use of antimicrobial agents poses a risk for the selection of resistant bacteria. Of particular interest are antibiotics that have large consumption rates in both veterinary and human medicine, such as the tetracyclines and macrolide-lincosamide-streptogramin (MLS) group of antibiotics. A high load of these agents increases the risk of transmission of resistant bacteria and/or resistance determinants to humans, leading to a subsequent therapeutic failure. An increasing incidence of bacteria resistant to both tetracyclines and MLS antibiotics has been recently observed. This review summarizes the current knowledge on different tetracycline and MLS resistance genes that can be linked together on transposable elements.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos dos fármacos
Bactérias/genética
Infecções Bacterianas/microbiologia
Farmacorresistência Bacteriana
Lincosamidas/farmacologia
Macrolídeos/farmacologia
Estreptograminas/farmacologia
Tetraciclinas/farmacologia
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacterial Proteins); 0 (Lincosamides); 0 (Macrolides); 0 (Streptogramins); 0 (Tetracyclines)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE


  9 / 3649 MEDLINE  
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[PMID]:28586654
[Au] Autor:Ding H; Wu Y; Zhang W; Zhong J; Lou Q; Yang P; Fang Y
[Ad] Endereço:School of Resource and Environmental Science, Wuhan University, Wuhan 430079, People's Republic of China; Jiangxi Provincial Key Laboratory of Water Resources and Environment of Poyang Lake, Jiangxi Institute of Water Sciences, Nanchang 330029, People's Republic of China; Ministry of Water Resources
[Ti] Título:Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China.
[So] Source:Chemosphere;184:137-147, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:SPE-UPLC-MS/MS was used to investigate the occurrence of 18 target antibiotics in the surface water of Poyang Lake over different seasons of 2014-2015. The maximum concentrations of sulfadiazine, oxytetracycline, and doxycycline were 56.2, 48.7, and 39.7 ng/L, respectively. Compared with those in the other lakes or surface waters, the surface water of Poyang Lake contained moderate or below-average levels of antibiotics. The significantly lower concentrations (P < 0.01) of roxithromycin in June 2015 likely resulted from the dilution effect of water flow during the flood season. Antibiotic concentrations were higher in site P3-1 than in other sites (P < 0.01), whereas those in other sites (P1-1, P2-1, P5-1, P6-1, P7-1, P13-1, P16-1, P17-1, P18-1) were not significantly different (P > 0.05). Given that tetracyclines and sulfonamides are common veterinary medicines, the high concentrations of oxytetracycline, doxycycline, and sulfadiazine in site P3-1 might be closely related to agricultural production in the surrounding areas. The risk assessment of the main antibiotic contaminants revealed that the majority of the risk quotients of the target antibiotics were below 0.01, thereby indicating the minimal risk of these antibiotics to organisms at three different trophic levels. Sulfadimidine and sulfadiazine were identified as the main antibiotics that contribute to ecological risk in Poyang Lake, and that the daphnid is the main model organism exposed to these risks. This study provides important data for antibiotic pollution control and environmental protection in the study area and enriches environmental monitoring data on a global scale.
[Mh] Termos MeSH primário: Antibacterianos/análise
Monitoramento Ambiental
Lagos/química
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: China
Lagos/análise
Medição de Risco
Estações do Ano
Espectrometria de Massas em Tandem
Tetraciclinas/análise
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Tetracyclines); 0 (Water Pollutants, Chemical); 059QF0KO0R (Water)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE


  10 / 3649 MEDLINE  
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[PMID]:28496033
[Au] Autor:Ding L; Zang L; Zhang Y; Zhang Y; Wang X; Ai W; Ding N; Wang H
[Ad] Endereço:School of Physical Education and Sport Sciences, Wenzhou Medical University, China.
[Ti] Título:Joint toxicity of fluoroquinolone and tetracycline antibiotics to zebrafish (Danio rerio) based on biochemical biomarkers and histopathological observation.
[So] Source:J Toxicol Sci;42(3):267-280, 2017.
[Is] ISSN:1880-3989
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Herein, we report on the joint toxicity of four fluoroquinolones and two tetracyclines (ß-diketone antibiotics-DKAs) to zebrafish based on a series of toxicological endpoints and histopathological observations. A positive dose-dependence was observed in DKA-exposure groups with a 72-hpf EC of 130.3 mg/L for hatching rate, 120-hpf LC of 149.8 mg/L, and 120-hpf EC of 135.1 mg/L for malformation rate. When zebrafish at 60 dpf were exposed to a series of DKA concentrations (45, 60 and 90 mg/L) for 7, 14 and 21 days, creatine kinase and AChE activities were significantly induced, and intracellular malondialdehyde increased in all treatments except for the 45 mg/L treatment. The transcription levels of AHRRa from livers were significantly (p < 0.05) up-regulated in all treatments after two months of DKA exposure. CKma expression from skeletal muscle was significantly down-regulated in the 90 mg/L treatment. A remarkable down-regulation of CYP3A65 was observed in the 60 mg/L treatment. DKA exposure resulted in severe tissue damage including mitochondria swelling, reduction of mitochondrial cristae, deepening of mitochondrial cristae bands, and decreasing and even disappearance of the rough endoplasmic reticulum. Total sperm motility was decreased by ca. 30% due to DKA exposure. These results provide important information for toxicity and health risks due to mixed DKA exposure in aquatic environments.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Antibacterianos/toxicidade
Hidrocarboneto de Aril Hidroxilases/genética
Hidrocarboneto de Aril Hidroxilases/metabolismo
Creatina Quinase/metabolismo
Fluoroquinolonas/toxicidade
Expressão Gênica/efeitos dos fármacos
Malondialdeído/metabolismo
Oxirredutases N-Desmetilantes/genética
Oxirredutases N-Desmetilantes/metabolismo
Motilidade Espermática/efeitos dos fármacos
Tetraciclinas/toxicidade
Proteínas de Peixe-Zebra/genética
Proteínas de Peixe-Zebra/metabolismo
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Regulação para Baixo/efeitos dos fármacos
Retículo Endoplasmático Rugoso/efeitos dos fármacos
Fígado/metabolismo
Mitocôndrias/efeitos dos fármacos
Dilatação Mitocondrial/efeitos dos fármacos
Proteínas Repressoras/genética
Reprodução/efeitos dos fármacos
Transcrição Genética/efeitos dos fármacos
Peixe-Zebra
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 0 (Repressor Proteins); 0 (Tetracyclines); 0 (Zebrafish Proteins); 0 (aryl hydrocarbon receptor repressor 1, Danio rerio); 4Y8F71G49Q (Malondialdehyde); EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases); EC 1.14.14.1 (cytochrome P-450 CYP3A65, zebrafish); EC 1.5.- (Oxidoreductases, N-Demethylating); EC 2.7.3.2 (Creatine Kinase); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.2131/jts.42.267



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