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[PMID]:27837439
[Au] Autor:Tzoulis P; Carr H; Bagkeris E; Bouloux PM
[Ad] Endereço:Centre for Neuroendocrinology, Royal Free Campus, University College London Medical School, London, NW3 2QG, UK. Ploutarchos.tzoulis@nhs.net.
[Ti] Título:Improving care and outcomes of inpatients with syndrome of inappropriate antidiuresis (SIAD): a prospective intervention study of intensive endocrine input vs. routine care.
[So] Source:Endocrine;55(2):539-546, 2017 Feb.
[Is] ISSN:1559-0100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The syndrome of inappropriate antidiuresis is often undertreated with most patients discharged with persistent hyponatraemia. This study tested the hypothesis that an endocrine input is superior to routine care in correcting hyponatraemia and can improve patient outcomes. METHODS: This single-centre prospective-controlled intervention study included inpatients admitted at a UK teaching hospital, with serum sodium ≤ 127 mmol/l, due to syndrome of inappropriate antidiuresis over a 6-month period. The prospective intervention group (18 subjects with mean serum sodium 120.7 mmol/l) received prompt endocrine input, while the historical control group (23 patients with mean serum sodium 124.1 mmol/l) received routine care. The time needed for serum sodium increase ≥ 5 mmol/l was the primary endpoint. RESULTS: The intervention group achieved serum sodium rise by ≥5 mmol/l in 3.5 vs. 7.1 days in the control group (P = 0.005). In the intervention group, the mean total serum sodium increase was 12 mmol/l with only 5.8 % of patients discharged with serum sodium < 130 vs. 6.3 mmol/l increase (P < 0.001) and 42.1 % of the subjects discharged with serum sodium < 130 mmol/l in the control group (P = 0.012). The mean length of hospital stay in the intervention group (10.9 days) was significantly shorter than in the control group (14.5 days; P = 0.004).The inpatient mortality rate was 5.5 % in intervention arm vs. 17.4 % in control arm, but this difference was not statistically significant. CONCLUSIONS: Since the endocrine input improved time for correction of hyponatraemia and shortened length of hospitalisation, widespread provision of endocrine input should be considered.
[Mh] Termos MeSH primário: Antagonistas de Receptores de Hormônios Antidiuréticos/uso terapêutico
Benzazepinas/uso terapêutico
Demeclociclina/uso terapêutico
Síndrome de Secreção Inadequada de HAD/terapia
Solução Salina Hipertônica/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Síndrome de Secreção Inadequada de HAD/sangue
Síndrome de Secreção Inadequada de HAD/tratamento farmacológico
Masculino
Meia-Idade
Estudos Prospectivos
Estudos Retrospectivos
Sódio/sangue
Resultado do Tratamento
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 0 (Saline Solution, Hypertonic); 21G72T1950 (tolvaptan); 5R5W9ICI6O (Demeclocycline); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161113
[St] Status:MEDLINE
[do] DOI:10.1007/s12020-016-1161-9


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[PMID]:27377565
[Au] Autor:Fatori Popovic S; Lübbers HT; von Mandach U
[Ad] Endereço:Cabinet dentaire privé Wiedikon, Dr Sandra Fatori and Partner, médecin-dentiste et médecin, Zurich, Switzerland.
[Ti] Título:[Pregnancy and lactation: antibiotics. mouthwashes and pastes or ointments.
[Ti] Título:Grossesse et allaitement: antibiotiques, solutions de rinçage de bouche et pâtes ou pommades..
[So] Source:Swiss Dent J;126(6):598-9, 2016.
[Is] ISSN:2296-6498
[Cp] País de publicação:Switzerland
[La] Idioma:fre
[Ab] Resumo:The aim of this paper is to show aspects of dental treatment in pregnancy. The reader should gain security in the election of the proper drugs for antibiotic therapy and rinsing solutions. Antibiotics as penicillins are the first choice in case of dental infections in pregnancy. In allergic patients, macrolides may be an alternative. Wound and mouth rinsing solutions containing chlorhexidine should be preferred in pregnancy. Ledermix(®) in endodontic treatment should be avoided in the pregnant woman. Solcoseryl(®) can be used for wound healing. Elective dental procedures should be postponed after delivery and after lactation period.
[Mh] Termos MeSH primário: Actiemil/efeitos adversos
Actiemil/uso terapêutico
Antibacterianos/efeitos adversos
Antibacterianos/uso terapêutico
Demeclociclina/efeitos adversos
Demeclociclina/uso terapêutico
Assistência Odontológica/métodos
Lactação
Antissépticos Bucais/efeitos adversos
Antissépticos Bucais/uso terapêutico
Efeitos Tardios da Exposição Pré-Natal
Triancinolona Acetonida/efeitos adversos
Triancinolona Acetonida/uso terapêutico
[Mh] Termos MeSH secundário: Combinação de Medicamentos
Feminino
Seres Humanos
Recém-Nascido
Gravidez
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drug Combinations); 0 (Mouthwashes); 37239-28-4 (Actihaemyl); 5R5W9ICI6O (Demeclocycline); 8059-68-5 (Ledermix); F446C597KA (Triamcinolone Acetonide)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160705
[Lr] Data última revisão:
160705
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160706
[St] Status:MEDLINE


  3 / 619 MEDLINE  
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[PMID]:27277144
[Au] Autor:Fatori Popovic S; Lübbers HT; von Mandach von Mandach U
[Ad] Endereço:Privatpraxis Zahnärzte Wiedikon – Dr. Fatori and Partner, Zahnärztin and Ärztin, Zentralstrasse 2, Zürich, Switzerland.
[Ti] Título:[Pregnancy and breast feeding: antibiotics, irrigation and pastes].
[Ti] Título:Schwangerschaft und Stillzeit: Antibiotika, Spülungen und Pasten..
[So] Source:Swiss Dent J;126(5):490-1, 2016.
[Is] ISSN:2296-6498
[Cp] País de publicação:Switzerland
[La] Idioma:ger
[Ab] Resumo:The aim of this paper is to show aspects of dental treatment in pregnancy. The reader should gain security in the election of the proper drugs for antibiotic therapy and rinsing solutions. Antibiotics as penicillins are the first choice in case of dental infections in pregnancy. In allergic patients, macrolides may be an alternative. Wound and mouth rinsing solutions containing chlorhexidine should be preferred in pregnancy. Ledermix(®) in endodontic treatment should be avoided in the pregnant woman. Solcoseryl(®) can be used for wound healing. Elective dental procedures should be postponed after delivery and after lactation period.
[Mh] Termos MeSH primário: Actiemil/uso terapêutico
Antibacterianos/uso terapêutico
Demeclociclina/uso terapêutico
Doenças da Boca/tratamento farmacológico
Antissépticos Bucais/uso terapêutico
Complicações Infecciosas na Gravidez/tratamento farmacológico
Odontopatias/tratamento farmacológico
Triancinolona Acetonida/uso terapêutico
[Mh] Termos MeSH secundário: Actiemil/efeitos adversos
Antibacterianos/efeitos adversos
Clorexidina/efeitos adversos
Clorexidina/uso terapêutico
Demeclociclina/efeitos adversos
Combinação de Medicamentos
Feminino
Seres Humanos
Antissépticos Bucais/efeitos adversos
Gravidez
Triancinolona Acetonida/efeitos adversos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drug Combinations); 0 (Mouthwashes); 37239-28-4 (Actihaemyl); 5R5W9ICI6O (Demeclocycline); 8059-68-5 (Ledermix); F446C597KA (Triamcinolone Acetonide); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160609
[Lr] Data última revisão:
160609
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE


  4 / 619 MEDLINE  
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[PMID]:26254597
[Au] Autor:Zaugg LK; Lenherr P; Zaugg JB; Weiger R; Krastl G
[Ad] Endereço:Department of Periodontology, Endodontology and Cariology, University of Basel, Hebelstrasse 3, 4056, Basel, Switzerland. lucia.zaugg@unibas.ch.
[Ti] Título:Influence of the bleaching interval on the luminosity of long-term discolored enamel-dentin discs.
[So] Source:Clin Oral Investig;20(3):451-8, 2016 Apr.
[Is] ISSN:1436-3771
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study is to investigate the influence of changing the sodium perborate-tetrahydrate (PBS-4) at a 4-day interval versus no change after 16 days of internal bleaching. MATERIALS AND METHODS: Two hundred and ten bovine enamel-dentin discs were discolored for 3.5 years with 14 different endodontic materials. All groups with a discoloring index of ∆E (mean) ≥ 5.5 were included in the present investigation: ApexCal (APCA), MTA white + blood (WMTA+BL), Portland cement + blood (PC+BL), blood (BL), MTA gray (GMTA), MTA gray + blood (GMTA+BL), Ledermix (LED), and triple antibiotic paste containing minocycline (3Mix). Fourteen specimens of each group were randomly assigned into two treatment groups: (1) no change of the PBS-4 (n = 7); (2) change of the PBS-4 every 4 days (n = 7). Color measurements were taken at 10 different time intervals and the L*a*b* values were recorded with a spectrophotometer (VITA Easyshade® compact). RESULTS: In the group 3Mix, significantly better results were achieved by changing the bleaching agent every 4 days (P = 0.0049; q = 0.04), while the group WMTA+BL indicated better results by no change of the bleaching agent (P = 0.0222, q = 0.09). All remaining groups showed no statistical difference between the two treatment procedures. CONCLUSIONS: Moderate discolorations can be successfully treated without changing the bleaching agent over a period of 16 days. Changing the sodium perborate-tetrahydrate every 4 days is preferred in case of severe discolored enamel-dentin discs only. CLINICAL RELEVANCE: This approach may offer a reduced number of clinical appointments and a secondary cost reduction to the patient.
[Mh] Termos MeSH primário: Esmalte Dentário/efeitos dos fármacos
Dentina/efeitos dos fármacos
Clareadores Dentários/química
Descoloração de Dente/terapia
[Mh] Termos MeSH secundário: Compostos de Alumínio
Animais
Boratos
Compostos de Cálcio
Bovinos
Ciprofloxacino
Demeclociclina
Cimentos Dentários
Combinação de Medicamentos
Técnicas In Vitro
Metronidazol
Minociclina
Óxidos
Distribuição Aleatória
Materiais Restauradores do Canal Radicular
Silicatos
Espectrofotometria
Fatores de Tempo
Clareamento Dental/métodos
Triancinolona Acetonida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3Mix ointment); 0 (Aluminum Compounds); 0 (ApexCal); 0 (Borates); 0 (Calcium Compounds); 0 (Dental Cements); 0 (Drug Combinations); 0 (Oxides); 0 (Root Canal Filling Materials); 0 (Silicates); 0 (Tooth Bleaching Agents); 0 (mineral trioxide aggregate); 140QMO216E (Metronidazole); 5E8K9I0O4U (Ciprofloxacin); 5R5W9ICI6O (Demeclocycline); 8059-68-5 (Ledermix); F446C597KA (Triamcinolone Acetonide); FYY3R43WGO (Minocycline); Y52BK1W96C (sodium perborate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:150810
[St] Status:MEDLINE
[do] DOI:10.1007/s00784-015-1545-x


  5 / 619 MEDLINE  
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Cohen, M
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[PMID]:26343423
[Au] Autor:Grant P; Ayuk J; Bouloux PM; Cohen M; Cranston I; Murray RD; Rees A; Thatcher N; Grossman A
[Ad] Endereço:Royal Sussex County Hospital, Brighton, UK.
[Ti] Título:Response to 'How we define hyponatremia?'.
[So] Source:Eur J Clin Invest;45(11):1218, 2015 Nov.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Algoritmos
Antibacterianos/uso terapêutico
Antagonistas de Receptores de Hormônios Antidiuréticos/uso terapêutico
Benzazepinas/uso terapêutico
Demeclociclina/uso terapêutico
Hidratação
Hiponatremia/terapia
Síndrome de Secreção Inadequada de HAD/terapia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 5R5W9ICI6O (Demeclocycline)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151023
[Lr] Data última revisão:
151023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150908
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12515


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[PMID]:26289137
[Au] Autor:Miell J; Dhanjal P; Jamookeeah C
[Ad] Endereço:Department of Endocrinology, University Hospital Lewisham, London, UK.
[Ti] Título:Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review.
[So] Source:Int J Clin Pract;69(12):1396-417, 2015 Dec.
[Is] ISSN:1742-1241
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Hyponatraemia (HN) is the most common electrolyte balance disorder in clinical practice. Since the 1970s, demeclocycline has been used in some countries to treat chronic HN secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH). The precise mechanism of action of demeclocycline is unclear, but has been linked to the induction of nephrogenic diabetes insipidus. Furthermore, the safety profile of demeclocycline is variable with an inconsistent time to onset, and a potential for complications. There has been no systematic evaluation of the use of demeclocycline for the treatment of HN secondary to SIADH to date. A systematic literature review was performed to obtain an insight into the clinical safety and efficacy of demeclocycline for this condition. METHODS: Embase(™) , MEDLINE(®) , MEDLINE(®) In-Process, and The Cochrane Library were searched on two occasions using MeSH terms combined with free-text terms. References were screened by two independent reviewers. Relevant publications were then extracted by two independent reviewers, with a third reviewer collating and finalising extractions. RESULTS: The searches returned a total of 705 hits. 632 abstracts were screened after the removal of duplicates. Following screening, 35 full-length publications were reviewed. Of these, 17 were excluded, resulting in 18 studies deemed relevant for data extraction. Two were randomised controlled trials (RCTs), 16 were non-RCTs, and 10 were case reports. DISCUSSION: Although most reports suggest that demeclocycline can address serum sodium levels in specific patients with HN, efficacy is variable, and may depend upon the underlying aetiology. Demeclocycline dose adjustments can be complex, and as its use in clinical practice is not well defined, it can differ between healthcare professionals. CONCLUSION: There is a lack of clinical and economic evidence supporting the use of demeclocycline for HN secondary to SIADH. Patients receiving demeclocycline for HN secondary to SIADH must be closely monitored.
[Mh] Termos MeSH primário: Demeclociclina/uso terapêutico
Hiponatremia/tratamento farmacológico
Síndrome de Secreção Inadequada de HAD/tratamento farmacológico
[Mh] Termos MeSH secundário: Demeclociclina/efeitos adversos
Seres Humanos
Hiponatremia/etiologia
Síndrome de Secreção Inadequada de HAD/complicações
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
5R5W9ICI6O (Demeclocycline)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150821
[St] Status:MEDLINE
[do] DOI:10.1111/ijcp.12713


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[PMID]:26259932
[Au] Autor:Cervellin G; Lippi G
[Ad] Endereço:Academic Hospital of Parma, Parma, Italy.
[Ti] Título:How we define hyponatraemia?
[So] Source:Eur J Clin Invest;45(11):1219, 2015 Nov.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Algoritmos
Antibacterianos/uso terapêutico
Antagonistas de Receptores de Hormônios Antidiuréticos/uso terapêutico
Benzazepinas/uso terapêutico
Demeclociclina/uso terapêutico
Hidratação
Hiponatremia/terapia
Síndrome de Secreção Inadequada de HAD/terapia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 5R5W9ICI6O (Demeclocycline)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151023
[Lr] Data última revisão:
151023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12516


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[PMID]:25995119
[Au] Autor:Grant P; Ayuk J; Bouloux PM; Cohen M; Cranston I; Murray RD; Rees A; Thatcher N; Grossman A
[Ad] Endereço:Royal Sussex County Hospital, Brighton, UK.
[Ti] Título:The diagnosis and management of inpatient hyponatraemia and SIADH.
[So] Source:Eur J Clin Invest;45(8):888-94, 2015 Aug.
[Is] ISSN:1365-2362
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hyponatraemia is a very common medical condition that is associated with multiple poor clinical outcomes and is often managed suboptimally because of inadequate assessment and investigation. Previously published guidelines for its management are often complex and impractical to follow in a hospital environment, where patients may present to divergent specialists, as well as to generalists. DESIGN: A group of senior, experienced UK clinicians, met to develop a practical algorithm for the assessment and management of hyponatraemia in a hospital setting. The latest evidence was discussed and reviewed in the light of current clinical practicalities to ensure an up-to-date perspective. An algorithm was largely developed following consensus opinion, followed up with subsequent additions and amendments that were agreed by all authors during several rounds of review. RESULTS: We present a practical algorithm which includes a breakdown of the best methods to evaluate volume status, simple assessments for the diagnosis of the various causes and a straightforward approach to treatment to minimise complexity and maximise patient safety. CONCLUSION: The algorithm we have developed reflects the best available evidence and extensive clinical experience and provides practical, useable guidance to improve patient care.
[Mh] Termos MeSH primário: Algoritmos
Antibacterianos/uso terapêutico
Antagonistas de Receptores de Hormônios Antidiuréticos/uso terapêutico
Benzazepinas/uso terapêutico
Demeclociclina/uso terapêutico
Hidratação
Hiponatremia/terapia
Síndrome de Secreção Inadequada de HAD/terapia
[Mh] Termos MeSH secundário: Hospitalização
Seres Humanos
Hiponatremia/diagnóstico
Síndrome de Secreção Inadequada de HAD/diagnóstico
Guias de Prática Clínica como Assunto
Desequilíbrio Hidroeletrolítico/diagnóstico
Desequilíbrio Hidroeletrolítico/terapia
[Pt] Tipo de publicação:CONSENSUS DEVELOPMENT CONFERENCE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antidiuretic Hormone Receptor Antagonists); 0 (Benzazepines); 21G72T1950 (tolvaptan); 5R5W9ICI6O (Demeclocycline)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160219
[Lr] Data última revisão:
160219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150522
[St] Status:MEDLINE
[do] DOI:10.1111/eci.12465


  9 / 619 MEDLINE  
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[PMID]:25790138
[Au] Autor:Wirth D; Smith TW; Moser R; Yaroslavsky AN
[Ad] Endereço:Department of Physics and Applied Physics, University of Massachusetts, Lowell 1 University Ave. Lowell, MA 01854, USA.
[Ti] Título:Demeclocycline as a contrast agent for detecting brain neoplasms using confocal microscopy.
[So] Source:Phys Med Biol;60(7):3003-11, 2015 Apr 07.
[Is] ISSN:1361-6560
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Complete resection of brain tumors improves life expectancy and quality. Thus, there is a strong need for high-resolution detection and microscopically controlled removal of brain neoplasms. The goal of this study was to test demeclocycline as a contrast enhancer for the intraoperative detection of brain tumors. We have imaged benign and cancerous brain tumors using multimodal confocal microscopy. The tumors investigated included pituitary adenoma, meningiomas, glioblastomas, and metastatic brain cancers. Freshly excised brain tissues were stained in 0.75 mg ml(-1) aqueous solution of demeclocyline. Reflectance images were acquired at 402 nm. Fluorescence signals were excited at 402 nm and registered between 500 and 540 nm. After imaging, histological sections were processed from the imaged specimens and compared to the optical images. Fluorescence images highlighted normal and cancerous brain cells, while reflectance images emphasized the morphology of connective tissue. The optical and histological images were in accordance with each other for all types of tumors investigated. Demeclocyline shows promise as a contrast agent for intraoperative detection of brain tumors.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Meios de Contraste
Demeclociclina
Microscopia Confocal/métodos
[Mh] Termos MeSH secundário: Encéfalo/patologia
Neoplasias Encefálicas/diagnóstico
Corantes Fluorescentes
Glioblastoma/diagnóstico
Glioma/diagnóstico
Glioma/patologia
Seres Humanos
Neoplasias Meníngeas/diagnóstico
Meningioma/diagnóstico
Metástase Neoplásica
Imagem Óptica
Neoplasias Hipofisárias/diagnóstico
Cintilografia
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (Fluorescent Dyes); 5R5W9ICI6O (Demeclocycline)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150320
[St] Status:MEDLINE
[do] DOI:10.1088/0031-9155/60/7/3003


  10 / 619 MEDLINE  
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[PMID]:25239672
[Au] Autor:Wirth D; Snuderl M; Curry W; Yaroslavsky A
[Ad] Endereço:University of Massachusetts Lowell, Department of Physics and Applied Physics, One University Avenue, Lowell, Massachusetts 01854, United States.
[Ti] Título:Comparative evaluation of methylene blue and demeclocycline for enhancing optical contrast of gliomas in optical images.
[So] Source:J Biomed Opt;19(9):90504, 2014 Sep.
[Is] ISSN:1560-2281
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Contrast agents have shown to be useful in the detection of cancers. The goal of this study was to compare enhancement of brain cancer contrast using reflectance and fluorescence confocal imaging of two fluorophores, methylene blue (MB) and demeclocycline (DMN). MB absorbs light in the red spectral range and fluoresces in the near-infrared. It is safe for in vivo staining of human skin and breast tissue. However, its safety for staining human brain is questionable. Thus, DMN, which absorbs light in the violet spectral range and fluoresces between 470 and 570 nm, could provide a safer alternative to MB. Fresh human gliomas, obtained from surgeries, were cut in half and stained with aqueous solutions of MB and DMN, respectively. Stained tissues were imaged using multimodal confocal microscopy. Resulting reflectance and fluorescence optical images were compared with hematoxylin and eosin histopathology, processed from each imaged tissue. Results indicate that images of tissues stained with either stain exhibit comparable contrast and resolution of morphological detail. Further studies are required to establish the safety and efficacy of these contrast agents for use in human brain.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Meios de Contraste/química
Demeclociclina/química
Glioma/patologia
Azul de Metileno/química
Imagem Óptica/métodos
[Mh] Termos MeSH secundário: Encéfalo/patologia
Química Encefálica
Neoplasias Encefálicas/química
Glioma/química
Seres Humanos
Processamento de Imagem Assistida por Computador
[Pt] Tipo de publicação:COMPARATIVE STUDY; LETTER; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Contrast Media); 5R5W9ICI6O (Demeclocycline); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140920
[Lr] Data última revisão:
140920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140921
[St] Status:MEDLINE
[do] DOI:10.1117/1.JBO.19.9.090504



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