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[PMID]:28863363
[Au] Autor:Turker G; Akyol Ç; Ince O; Aydin S; Ince B
[Ad] Endereço:Institute of Environmental Sciences, Bogaziçi University, Bebek, 34342 Istanbul, Turkey.
[Ti] Título:Operating conditions influence microbial community structures, elimination of the antibiotic resistance genes and metabolites during anaerobic digestion of cow manure in the presence of oxytetracycline.
[So] Source:Ecotoxicol Environ Saf;147:349-356, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The way that antibiotic residues in manure follow is one of the greatest concerns due to its potential negative impacts on microbial communities, the release of metabolites and antibiotic resistant genes (ARGs) into the nature and the loss of energy recovery in anaerobic digestion (AD) systems. This study evaluated the link between different operating conditions, the biodegradation of oxytetracycline (OTC) and the formation of its metabolites and ARGs in anaerobic digesters treating cow manure. Microbial communities and ARGs were determined through the use of quantitative real-time PCR. The biodegradation of OTC and occurrence of metabolites were determined using UV-HPLC and LC/MS/MS respectively. The maximum quantity of resistance genes was also examined at the beginning of AD tests and concentration was in the order of: tetM >tetO. The numbers of ARGs were always higher at high volatile solids (VS) content and high mixing rate. The results of the investigation revealed that relationship between mixing rate and VS content plays a crucial role for elimination of ARGs, OTC and metabolites. This can be attributed to high abundance of microorganisms due to high VS content and their increased contact with elevated mixing rate. An increased interaction between microorganisms triggers the promotion of ARGs.
[Mh] Termos MeSH primário: Antibacterianos/toxicidade
Reatores Biológicos/microbiologia
Resistência Microbiana a Medicamentos/genética
Esterco/microbiologia
Consórcios Microbianos/efeitos dos fármacos
Oxitetraciclina/toxicidade
[Mh] Termos MeSH secundário: Anaerobiose
Animais
Antibacterianos/metabolismo
Biodegradação Ambiental
Bovinos
Cromatografia Líquida de Alta Pressão
Feminino
Esterco/análise
Consórcios Microbianos/genética
Oxitetraciclina/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Manure); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


  2 / 3770 MEDLINE  
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[PMID]:29268103
[Au] Autor:Carusso S; Juárez AB; Moretton J; Magdaleno A
[Ad] Endereço:Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Salud Pública e Higiene Ambiental, Junin 956, 4° Piso, C1113 AAC, Buenos Aires, Argentina; Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales, Departamento de Biodiversidad y Biología Experimental y Departa
[Ti] Título:Effects of three veterinary antibiotics and their binary mixtures on two green alga species.
[So] Source:Chemosphere;194:821-827, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The individual and combined toxicities of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) have been examined in two green algae representative of the freshwater environment, the international standard strain Pseudokichneriella subcapitata and the native strain Ankistrodesmus fusiformis. The toxicities of the three antibiotics and their mixtures were similar in both strains, although low concentrations of ENF and CTC + ENF were more toxic in A. fusiformis than in the standard strain. The toxicological interactions of binary mixtures were predicted using the two classical models of additivity: Concentration Addition (CA) and Independent Action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 0.1 and 10 mg L . The CA model predicted the inhibition of algal growth in the three mixtures in P. subcapitata, and in the CTC + OTC and CTC + ENF mixtures in A. fusiformis. However, this model underestimated the experimental results obtained in the OTC + ENF mixture in A. fusiformis. The IA model did not predict the experimental toxicological effects of the three mixtures in either strain. The sum of the toxic units (TU) for the mixtures was calculated. According to these values, the binary mixtures CTC + ENF and OTC + ENF showed an additive effect, and the CTC + OTC mixture showed antagonism in P. subcapitata, whereas the three mixtures showed synergistic effects in A. fusiformis. Although A. fusiformis was isolated from a polluted river, it showed a similar sensitivity with respect to P. subcapitata when it was exposed to binary mixtures of antibiotics.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Clorófitas/efeitos dos fármacos
Drogas Veterinárias/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/toxicidade
Clortetraciclina/toxicidade
Interações Medicamentosas
Fluoroquinolonas/toxicidade
Biologia de Ecossistemas de Água Doce
Oxitetraciclina/toxicidade
Drogas Veterinárias/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); 0 (Veterinary Drugs); 3DX3XEK1BN (enrofloxacin); WCK1KIQ23Q (Chlortetracycline); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


  3 / 3770 MEDLINE  
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[PMID]:28578323
[Au] Autor:Shah SA; Ishinaga H; Takeuchi K
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
[Ti] Título:Oxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells.
[So] Source:Chemotherapy;62(5):301-306, 2017.
[Is] ISSN:1421-9794
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Oxytetracycline is a broad-spectrum antibiotic, but its nonantibacterial effects in the human respiratory tract are unknown. In this study, the effects of oxytetracycline on mucus secretion and inflammation were examined by PCR and ELISA in the human airway epithelial cell line NCI-H292. Oxytetracycline (10 µg/mL) significantly inhibited TNF-α-induced MUC5AC gene expression and MUC5AC protein levels in NCI-H292 cells. It also downregulated IL-8 and IL-1ß gene expression and IL-1ß protein levels. Our findings demonstrated that oxytetracycline suppressed mucus production and inflammation in human respiratory epithelial cells, providing further evidence for the usefulness of oxytetracycline for human airway inflammatory diseases.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Muco/secreção
Oxitetraciclina/efeitos adversos
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Linhagem Celular
Regulação para Baixo/efeitos dos fármacos
Células Epiteliais/citologia
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/metabolismo
Células Epiteliais/secreção
Seres Humanos
Inflamação
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Interleucina-8/genética
Interleucina-8/metabolismo
Mucina-5AC/genética
Mucina-5AC/metabolismo
NF-kappa B/metabolismo
Oxitetraciclina/farmacologia
Sistema Respiratório/citologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Interleukin-1beta); 0 (Interleukin-8); 0 (MUC5AC protein, human); 0 (Mucin 5AC); 0 (NF-kappa B); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170605
[St] Status:MEDLINE
[do] DOI:10.1159/000475983


  4 / 3770 MEDLINE  
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[PMID]:28521163
[Au] Autor:Zhang F; Yue Q; Gao Y; Gao B; Xu X; Ren Z; Jin Y
[Ad] Endereço:Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan 250100, China.
[Ti] Título:Application for oxytetracycline wastewater pretreatment by Fenton iron mud based cathodic-anodic-electrolysis ceramic granular fillers.
[So] Source:Chemosphere;182:483-490, 2017 Sep.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, Fenton iron mud applied as main raw material of cathodic-anodic-electrolysis ceramic granular fillers (ICMF) in a continuous reactor, which were used to pretreat oxytetracycline (OTC) wastewater. The ICMF was characterized by Scanning Electron Microscope and Energy Dispersive Spectrometer analysis. The effects of pH value, hydraulic retention time, OTC concentrations and aeration on removal efficiency of total organic carbon (TOC) and OTC were studied. The degradation byproducts of OTC were analyzed by UV-2450, High Performance Liquid Chromatography and Liquid Chromatography-mass Spectrometry. The SEM images showed that the surface ICMF was porous. This system had a higher stability, and good removal efficiency of TOC of 80.5% and OTC of 98.5% under the optimal conditions, which were influent pH of 3, HRT of 4 h, and anaerobic condition. After running for 60 d, the removal efficiency of TOC was stable and the ICMF did not become hardened. The reactor was back washed by acid solution (pH: 1) in 20 d approximately. This paper provides useful information for approaching in wastewater pretreatment and recycling the Fenton iron mud.
[Mh] Termos MeSH primário: Cerâmica/química
Peróxido de Hidrogênio/química
Ferro/química
Oxitetraciclina/análise
Águas Residuais/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Eletrodos
Eletrólise
Filtração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fenton's reagent); 0 (Waste Water); 0 (Water Pollutants, Chemical); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE


  5 / 3770 MEDLINE  
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[PMID]:28500886
[Au] Autor:Aghababaei A; Ncibi MC; Sillanpää M
[Ad] Endereço:Laboratory of Green Chemistry, School of Engineering Science, Lappeenranta University of Technology, Sammonkatu 12, 50130 Mikkeli, Finland.
[Ti] Título:Optimized removal of oxytetracycline and cadmium from contaminated waters using chemically-activated and pyrolyzed biochars from forest and wood-processing residues.
[So] Source:Bioresour Technol;239:28-36, 2017 Sep.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present investigation, the adsorptive removal of the antibiotic drug oxytetracycline (OTC) and toxic heavy metal cadmium (Cd) from aqueous solution was carried out using forest and wood-processing residues. Numerous biochars were prepared using different chemical agents (H PO , H SO , NaOH and KOH) and pyrolysis times and temperatures. Several elemental, chemical and structural characterizations were performed. The optimum conditions for pyrolysis to enable the production of biochars with well-developed porosity was 600°C for 1h, for both residues. The adsorption process using selected activated biochars was optimized with respect to reaction time, pH, temperature and initial load of pollutants. Under optimized operating conditions, and based on equilibrium modelling data, the biochars which showed the highest removal efficiencies of OTC and cadmium were "5M H PO forest" (263.8mg/g) and "1M NaOH forest" (79.30mg/g), respectively. Compared to adsorbents reported in the literature, the efficiencies of those biochars are highly competitive.
[Mh] Termos MeSH primário: Cádmio
Oxitetraciclina
Purificação da Água
[Mh] Termos MeSH secundário: Adsorção
Carvão Vegetal
Agricultura Florestal
Florestas
Poluentes Químicos da Água
Madeira
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 0 (biochar); 00BH33GNGH (Cadmium); 16291-96-6 (Charcoal); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170514
[St] Status:MEDLINE


  6 / 3770 MEDLINE  
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[PMID]:28476972
[Au] Autor:SadguruPrasad LT; Madhusudhan B; Kodihalli B P; Ghosh PC
[Ad] Endereço:Research Center for Nanoscience and Technology, Department of Biochemistry and Food Technology, Davangere University, Davangere 577002, Karnataka, India.
[Ti] Título:Development and evaluation of oxytetracycline-loaded PMMA nanoparticles for oral delivery against anaplasmosis.
[So] Source:IET Nanobiotechnol;11(1):119-126, 2017 Feb.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Poly-methyl methacrylate (PMMA) polymer with remarkable properties and merits are being preferred in various biomedical applications due to its biocompatibility, non-toxicity and cost effectiveness. In this investigation, oxytetracycline-loaded PMMA nanoparticles were prepared using nano-precipitation method for the treatment of anaplasmosis. The prepared nanoparticles were characterised using dynamic light scattering (DLS), atomic force microscopy (AFM), differential scanning calorimetry (DSC) and Fourier transform infrared (FTIR) spectroscopy. The mean average diameter of the nanoparticles ranged between 190-240 nm and zeta potential was found to be -19 mV. The drug loading capacity and entrapment efficiency of nanoparticles was found varied between 33.7-62.2% and 40.5-60.0%. The drug release profile exhibited a biphasic phenomenon indicating controlled drug release. The uptake of coumarin-6(C-6)-loaded PMMA nanoparticles in ( 3D7) culture model was studied. The preferential uptake of C-6-loaded nanoparticles by the Plasmodium infected erythrocytes in comparison with the uninfected erythrocytes was observed under fluorescence microscopy. These findings suggest that oxytetracycline-loaded PMMA nanoparticles were found to be an effective oral delivery vehicle and an alternative pharmaceutical formulation in anaplasmosis treatment, too.
[Mh] Termos MeSH primário: Anaplasmose/tratamento farmacológico
Preparações de Ação Retardada/administração & dosagem
Nanocápsulas/administração & dosagem
Nanocápsulas/química
Oxitetraciclina/administração & dosagem
Polimetil Metacrilato/química
[Mh] Termos MeSH secundário: Absorção Fisico-Química
Administração Oral
Antibacterianos/administração & dosagem
Antibacterianos/química
Células Cultivadas
Preparações de Ação Retardada/síntese química
Difusão
Eritrócitos/química
Eritrócitos/microbiologia
Seres Humanos
Nanocápsulas/ultraestrutura
Oxitetraciclina/química
Tamanho da Partícula
Plasmodium falciparum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Delayed-Action Preparations); 0 (Nanocapsules); 9011-14-7 (Polymethyl Methacrylate); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0061


  7 / 3770 MEDLINE  
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[PMID]:28291385
[Au] Autor:Cornejo J; Pokrant E; Krogh M; Briceño C; Hidalgo H; Maddaleno A; Araya-Jordán C; Martín BS
[Ad] Endereço:1 Preventive Medicine Department (ORCID: http://orcid.org/0000-0001-5641-9562 [J.C.]).
[Ti] Título:Determination of Oxytetracycline and 4-Epi-Oxytetracycline Residues in Feathers and Edible Tissues of Broiler Chickens Using Liquid Chromatography Coupled with Tandem Mass Spectrometry.
[So] Source:J Food Prot;80(4):619-625, 2017 Apr.
[Is] ISSN:1944-9097
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Antibiotics have been widely used in poultry production for the treatment of bacterial diseases. However, drug residues can remain in products derived from animals after the cessation of the drug therapies. Feathers, in particular, have shown an affinity for antibiotics such as tetracycline, suggesting the persistence of these drugs in nonedible tissue. After the birds are slaughtered, feathers are ground into feather meals, which are used as organic fertilizer or an ingredient in animal diets, thereby entering into the food chain and becoming a potential risk for public health. To evaluate the depletion of oxytetracycline (OTC) and its metabolite 4-epi-oxytetracycline (4-epi-OTC) in the muscles, liver, and feathers, 64 broiler chickens, bred under controlled conditions, were treated orally with a commercial formulation of 10% OTC for 7 days. The analytes were quantified using liquid chromatography-tandem mass spectrometry. OTC and 4-epi-OTC were found in the feathers for 46 days, whereas they were found in the muscle and liver for only 12 and 6 days, respectively. These results prove that the analytes remain in feathers in higher concentrations than they do in edible tissues after treatment with tetracyclines. Thus, feather meals represent a potential source of antimicrobial residue contamination in the food chain.
[Mh] Termos MeSH primário: Resíduos de Drogas
Oxitetraciclina/análise
Espectrometria de Massas em Tandem
[Mh] Termos MeSH secundário: Animais
Antibacterianos
Galinhas/metabolismo
Cromatografia Líquida
Plumas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.4315/0362-028X.JFP-16-320


  8 / 3770 MEDLINE  
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[PMID]:28284554
[Au] Autor:Duan M; Li H; Gu J; Tuo X; Sun W; Qian X; Wang X
[Ad] Endereço:College of Natural Resources and Environment, Northwest A&F University, Yangling, People's Republic of China.
[Ti] Título:Effects of biochar on reducing the abundance of oxytetracycline, antibiotic resistance genes, and human pathogenic bacteria in soil and lettuce.
[So] Source:Environ Pollut;224:787-795, 2017 May.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antibiotics and antibiotic resistance genes (ARGs) in soil can affect human health via the food chain. Biochar is a soil amendment but its impacts on ARGs and the microbial communities associated with soil and vegetables are unclear. Therefore, we established three lettuce pot culture experiments, i.e., O300: 300 mg/kg oxytetracycline (OTC), BO300: 300 mg/kg OTC + 2% biochar, and a control without OTC or biochar. We found that under BO300, the relative abundances of ARGs were reduced by 51.8%, 43.4%, and 44.1% in lettuce leaves, roots, and soil, respectively, compared with O300. intI1 was highly abundant in soil and lettuce, and it co-occurred with some ARGs (tetW, ermF, and sul1). Redundancy analysis and network analysis indicated that the bacterial community succession was the main mechanism that affected the variations in ARGs and intI1. The reduction of Firmicutes due to the biochar treatment of soil and lettuce was the main factor responsible for the removal of tetracycline resistance genes in leaves. Biochar application led to the disappearance of human pathogenic bacteria (HPB), which was significantly correlated with the abundances of ermF and ermX. In summary, biochar is an effective farmland amendment for reducing the abundances of antibiotics, ARGs, and HPB in order to ensure the safety of vegetables and protect human health.
[Mh] Termos MeSH primário: Antibacterianos/análise
Bactérias/efeitos dos fármacos
Carvão Vegetal/farmacologia
Alface/microbiologia
Oxitetraciclina/análise
[Mh] Termos MeSH secundário: Resistência Microbiana a Medicamentos/genética
Genes Bacterianos/efeitos dos fármacos
Alface/efeitos dos fármacos
Microbiologia do Solo
Tetraciclina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (biochar); 16291-96-6 (Charcoal); F8VB5M810T (Tetracycline); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170313
[St] Status:MEDLINE


  9 / 3770 MEDLINE  
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[PMID]:28272051
[Au] Autor:Lv J; Ma Y; Chang X; Fang J; Cai L; Ma Y; Fan S
[Ad] Endereço:State Key Laboratory Cultivation Base of Energy Sources and Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
[Ti] Título:Chemical adsorption of oxytetracycline from aqueous solution by modified molecular sieves.
[So] Source:Water Sci Technol;75(5-6):1221-1232, 2017 03.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The removal of oxytetracycline (OTC) from aqueous solution on modified molecular sieve via adsorption was investigated in the present work. The copper(II) modified molecular sieve had the much higher adsorbed amount than unmodified one. The bigger pore, the more adsorption sites benefitted for the adsorbed amount of OTC. The exchanged amount of copper(II) and the acid-base property of solution were important factors influencing the removal efficiency. The adsorption kinetics, the adsorption isotherm, the adsorption thermodynamics and the proposed adsorption mechanism were studied. The analysis of adsorption isotherm indicated it is a monolayer adsorption. The fitting with adsorption kinetics, pseudo-second-order model, deduced chemical adsorption is the main rate controlling step. And the new formation of Cu-O chemical bond and the changes at bands of N-H vibration and C-N vibration by Fourier transform infrared spectrometer further confirmed the proposal adsorption mechanism was the chemical complexation of copper(II) in modified 13X with NH group of OTC. As the real exchanged amount of copper(II) was 149.07 mg·g and the solution pH 7.0, the adsorption capacity of modified 13X for OTC reached the maximum of 2,396 mg·g (with the initial concentration of 1,000 mg·L ).
[Mh] Termos MeSH primário: Oxitetraciclina/isolamento & purificação
Poluentes Químicos da Água/isolamento & purificação
Purificação da Água/instrumentação
[Mh] Termos MeSH secundário: Ácidos/química
Adsorção
Cobre/química
Difusão
Concentração de Íons de Hidrogênio
Cinética
Modelos Teóricos
Soluções
Espectroscopia de Infravermelho com Transformada de Fourier
Temperatura Ambiente
Termodinâmica
Fatores de Tempo
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids); 0 (Solutions); 0 (Water Pollutants, Chemical); 789U1901C5 (Copper); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2016.604


  10 / 3770 MEDLINE  
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[PMID]:28166965
[Au] Autor:Polasek TCM; Kozicki LE; Pedrosa VB; Weiss RR; Bertol MAF; Camargo CE; Talini R
[Ad] Endereço:Master of Animal Science, School of Life Sciences, Pontifical Catholic University of Paraná, Curitiba, Paraná, Brazil.
[Ti] Título:Impact of a progesterone-releasing intravaginal device and inflammatory reaction on ovarian activity in embryo-recipient anestrus mares.
[So] Source:Theriogenology;90:175-184, 2017 Mar 01.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to correlate the inflammatory reaction (IR) caused by a progesterone-releasing intravaginal device (P4) with ovarian activity and pregnancy rate (PR) in embryo-recipient anestrus mares (to decrease the spring transitional period). 50 animals were assigned to three groups: GP4 (P4 group; n = 16), GP4OH (P4 + oxytetracycline hydrochloride and hydrocortisone sprayed onto the device; n = 14), and GNP4 (no intravaginal P4; n = 20). The administration protocol for GP4 was: Day 0, 750 mg P4 + ovarian examination by ultrasonography (US) + vaginal sample collection; Day 8, US; Day 11, P4 removal + 7.5 mg PGF2α + US + second vaginal sample collection; Days 13 to 16, US; Days 17 to 21, US + 750 IU hCG to mares with follicles 35 mm or more in diameter; Days 19 to 23 US (ovulation check); Days 24 to 28, embryo transfer + intravenous flunixin meglumine; and Days 30, US pregnancy diagnosis. The GP4OH and GNP4 mares received the same administration protocol as GP4, except that no P4 device was administered to the GNP4 group on Day 0. Although neutrophil-mediated IR occurred in the GP4 and GP4OH groups, the IR was significantly reduced in GP4OH as compared with that in GP4 (P < 0.0001). From Day 0 to Day 17, the GP4 and GP4OH mares developed a greater number of follicles per animal than did the GNP4 mares (P < 0.05), and the average diameter of the follicles was larger in the GP4 and GP4OH mares. The ovulation rates in GP4, GP4OH, and GNP4 mares were, respectively, 43.7%, 64.3%, and 30.0%, and ovulation occurred at 6.8, 6.5, and 23 days after P4 removal (P < 0.05). On Day 17, endometrial edema was verified in 50%, 64.2%, and 35.0% of the GP4, GP4OH, and GNP4 mares, and the PRs after embryo transfer were 80%, 100%, and 66.6%, respectively. Although intravaginal devices caused IR in both the device-recipient groups (P = 0.0001), IR and vaginitis had no negative impact on follicle diameter, ovulation rate, period to ovulation after the removal of P4, endometrial edema, or PR. In addition, P4 reactivated the ovarian function and the IR eliminated a large percentage of bacteria (Bacillus spp., Enterobacter spp., Proteus spp., Pseudomonas spp., and Staphylococcus spp.), especially in GP4; the application of oxytetracycline hydrochloride and hydrocortisone on the devices reduced the severity of vaginitis.
[Mh] Termos MeSH primário: Implantes de Medicamento/efeitos adversos
Transferência Embrionária/veterinária
Cavalos
Folículo Ovariano/efeitos dos fármacos
Progesterona/administração & dosagem
Vaginite/veterinária
[Mh] Termos MeSH secundário: Administração Intravaginal
Animais
Escherichia coli/isolamento & purificação
Feminino
Hidrocortisona/administração & dosagem
Folículo Ovariano/fisiologia
Ovulação/efeitos dos fármacos
Oxitetraciclina/administração & dosagem
Gravidez
Taxa de Gravidez
Progesterona/efeitos adversos
Streptococcus/isolamento & purificação
Vaginite/induzido quimicamente
Vaginite/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Implants); 4G7DS2Q64Y (Progesterone); WI4X0X7BPJ (Hydrocortisone); X20I9EN955 (Oxytetracycline)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE



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