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  1 / 15943 MEDLINE  
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[PMID]:29175397
[Au] Autor:Dong G; Huang L; Wu X; Wang C; Liu Y; Liu G; Wang L; Liu X; Xia H
[Ad] Endereço:Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, China. Electronic address: 963722867@qq.com.
[Ti] Título:Effect and mechanism analysis of MnO on permeable reactive barrier (PRB) system for the removal of tetracycline.
[So] Source:Chemosphere;193:702-710, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Effect of manganese dioxide (MnO ) on tetracycline (TC) removal/degradation in zero-valent iron (ZVI) based permeable reactive barrier (PRB) system was investigated. To analyze the role of MnO , three different PRB columns packed with ZVI, ZVI and a layer of MnO , and MnO were set up to investigate the removal effect and reaction mechanism of ZVI coupling with MnO on TC removal, respectively. The results show that the removal efficiencies of three PRB columns are 65%, 85%, and 50%, respectively. MnO could accelerate the transformation of Fe into Fe and combine with Fe to degrade TC in different reaction sites in the ZVI-MnO PRB system. Hydroxyl radicals (·OH) were produced in this process, which contributed to about 58.3% for the TC degradation. The UV-Vis spectrum demonstrated that A ring of TC was the main reaction site for interaction with Fe and the BCD rings were crucial for interactions with MnO . On the basis of intermediates identified by LC-ESI-MS, the ring structure of TC was opened, and low-molecular-weight compounds were produced in ZVI-MnO PRB system.
[Mh] Termos MeSH primário: Ferro/química
Compostos de Manganês/farmacologia
Óxidos/farmacologia
Tetraciclina/isolamento & purificação
[Mh] Termos MeSH secundário: Sítios de Ligação
Cromatografia Líquida
Estrutura Molecular
Espectrometria de Massas em Tandem
Tetraciclina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Manganese Compounds); 0 (Oxides); E1UOL152H7 (Iron); F8VB5M810T (Tetracycline); TF219GU161 (manganese dioxide)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


  2 / 15943 MEDLINE  
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[PMID]:28841526
[Au] Autor:Rostamian R; Behnejad H
[Ad] Endereço:Department of Physical Chemistry, School of Chemistry, University College of Science, University of Tehran, Tehran 14155, Iran.
[Ti] Título:A comprehensive adsorption study and modeling of antibiotics as a pharmaceutical waste by graphene oxide nanosheets.
[So] Source:Ecotoxicol Environ Saf;147:117-123, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The adsorption behavior of tetracycline (TCN), doxycycline (DCN) as the most common antibiotics in veterinary and ciprofloxacin (CPN) onto graphene oxide nanosheets (GOS) in aqueous solution was evaluated. The four factors influencing the adsorption of antibiotics (initial concentration, pH, temperature and contact time) were studied. The results showed that initial pH ∼ 6 to 7 and contact time ∼ 100 - 200min are optimum for each drug. The monolayer adsorption capacity was reduced with the increasing temperature from 25°C to 45°C. Non-linear regressions were carried out in order to define the best fit model for every system. To do this, eight error functions were applied to predict the optimum model. Among various models, Hill and Toth isotherm models represented the equilibrium adsorption data of antibiotics while the kinetic data were well fitted by pseudo second-order (PSO) kinetic model (DCN and TCN) and Elovich (CPN) models. The maximum adsorption capacity (q ) is found to be in the following order: CPN >> DCN > TCN, obtained from sips equation at the same temperature. The GOS shows highest adsorption capacity towards CPN up to 173.4mgg . The study showed that GOS can be removed more efficiently from water solution.
[Mh] Termos MeSH primário: Antibacterianos/análise
Grafite/química
Modelos Teóricos
Nanoestruturas/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
[Mh] Termos MeSH secundário: Adsorção
Antibacterianos/química
Ciprofloxacino/análise
Ciprofloxacino/química
Doxiciclina/análise
Doxiciclina/química
Concentração de Íons de Hidrogênio
Cinética
Óxidos/química
Temperatura Ambiente
Tetraciclina/análise
Tetraciclina/química
Termodinâmica
Drogas Veterinárias/análise
Drogas Veterinárias/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Oxides); 0 (Veterinary Drugs); 0 (Water Pollutants, Chemical); 5E8K9I0O4U (Ciprofloxacin); 7782-42-5 (Graphite); F8VB5M810T (Tetracycline); N12000U13O (Doxycycline)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  3 / 15943 MEDLINE  
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[PMID]:29395080
[Au] Autor:Gopalan A; Bhagavat R; Chandra N; Subbarao SH; Raja A; Bethunaickan R
[Ad] Endereço:Department of Immunology, National Institute for Research in Tuberculosis, Chennai, India.
[Ti] Título:Biophysical and biochemical characterization of Rv3405c, a tetracycline repressor protein from Mycobacterium tuberculosis.
[So] Source:Biochem Biophys Res Commun;496(3):799-805, 2018 02 12.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mycobacterium tuberculosis, the causative agent of tuberculosis disease, is one among the deadliest pathogens in the world. Due to long treatment regimen, HIV co-infection, persistence of bacilli in latent form and development of XDR and TDR strains of Mtb, tuberculosis has posed serious concerns for managing the disease, and calls for discovery of new drugs and drug targets. Using a computational pipeline involving analysis of the structural models of the Mtb proteome and an analysis of the ATPome, followed by a series of filters to identify druggable proteins, solubility and length of the protein, several candidate proteins were shortlisted. From this, Rv3405c, a tetR family of DNA binding protein involved in antibiotic resistance, was identified as one of the good drug targets. Rv3405c binds to the upstream non-coding region of Rv3406 and causes repression of Rv3406 activity there by affecting the downstream processes involved in antibiotic resistance was further characterized. The Rv3405c gene was cloned; the gene product was over-expressed in E. coli and purified by Ni NTA chromatography. DNA binding studies by EMSA showed that the recombinant Rv3405c protein binds to the DNA sequence corresponding to the promoter region of Rv3406 and upon addition of tetracycline, the DNA binding activity was lost. ß-galactosidase reporter assay in E. coli using both wild type and a DNA binding defective mutant protein indeed proved that Rv3405c acts as a repressor.
[Mh] Termos MeSH primário: Proteínas de Bactérias/química
Proteínas de Bactérias/metabolismo
Proteínas de Ligação a DNA/química
Proteínas de Ligação a DNA/metabolismo
Mycobacterium tuberculosis/metabolismo
Tetraciclina/química
Tetraciclina/metabolismo
[Mh] Termos MeSH secundário: Antituberculosos/química
Sítios de Ligação
Avaliação Pré-Clínica de Medicamentos
Resistência Microbiana a Medicamentos/fisiologia
Ligação Proteica
Proteínas Repressoras
Resistência a Tetraciclina/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antitubercular Agents); 0 (Bacterial Proteins); 0 (DNA-Binding Proteins); 0 (Repressor Proteins); 0 (Rv3405c protein, Mycobacterium tuberculosis); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180204
[St] Status:MEDLINE


  4 / 15943 MEDLINE  
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[PMID]:29025658
[Au] Autor:Zhou J; Frank MA; Yang Y; Boccaccini AR; Virtanen S
[Ad] Endereço:Institute for Surface Science and Corrosion, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Germany.
[Ti] Título:A novel local drug delivery system: Superhydrophobic titanium oxide nanotube arrays serve as the drug reservoir and ultrasonication functions as the drug release trigger.
[So] Source:Mater Sci Eng C Mater Biol Appl;82:277-283, 2018 Jan 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A local drug delivery system consisting of superhydrophobic titanium oxide nanotube (S-TNTs) arrays and ultrasonic-controlled release trigger was developed in this work. Hydrophilic TNTs arrays are converted into superhydrophobic after being treated by 1H,1H,2H,2H- perfluorooctyl-triethoxysilane (POTS). S-TNTs arrays serving as a drug-carrying vehicle require no extra sealing treatment due to the excellent isolation effect from the trapped air layer on the surface. Different amounts of drugs could be loaded into S-TNTs arrays by control of the structure of arrays (including length and diameter of tubes) and the original amount of drug in the drug-loading solution. The relation between surface morphology of TNTs arrays and superhydrophobicity (isolation effect) was thoroughly investigated. To achieve a stimulus-responsive drug delivery system, ultrasonication was employed as an efficient drug release trigger. Trapped air layer could be selectively removed by ultrasonication, and therefore the loaded drug could be released in a multiple and controlled manner. Any drugs that can dissolve in nonpolar solutions are expected to be suitable for this local drug delivery system.
[Mh] Termos MeSH primário: Portadores de Fármacos/química
Nanotubos/química
Titânio/química
[Mh] Termos MeSH secundário: Liberação Controlada de Fármacos
Eletrólitos/química
Interações Hidrofóbicas e Hidrofílicas
Sonicação
Espectrofotometria
Propriedades de Superfície
Tetraciclina/química
Tetraciclina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Electrolytes); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171014
[St] Status:MEDLINE


  5 / 15943 MEDLINE  
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[PMID]:29310375
[Au] Autor:Funahara M; Yanamoto S; Ueda M; Suzuki T; Ota Y; Nishimaki F; Kurita H; Yamakawa N; Kirita T; Okura M; Mekaru Y; Arakaki K; Umeda M
[Ad] Endereço:Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki.
[Ti] Título:Prevention of surgical site infection after oral cancer surgery by topical tetracycline: Results of a multicenter randomized control trial.
[So] Source:Medicine (Baltimore);96(48):e8891, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In a pilot study, we showed that topical administration of a tetracycline could decrease oral bacteria levels for 6 hours in patients who underwent oral cancer surgery combined with tracheotomy and flap reconstruction. This multicenter, randomized control trial aimed to investigate the effectiveness of topical application of tetracycline ointment for prevention of surgical site infection (SSI) associated with major oral cancer surgery. METHODS: One hundred seventeen patients who underwent oral cancer resection combined with neck dissection, flap reconstruction, and tracheotomy were divided randomly into an intervention group (n = 56) and a control group (n = 61). The intervention consisted of topical administration of tetracycline ointment on the dorsum of the tongue every 6 hours for 48 hours postoperatively. Factors relating to the occurrence of SSI in both groups were subjected to logistic regression analysis. RESULTS: SSI occurred in 11 patients (19.6%) in the intervention group and 22 patients (36.1%) in the control group. Multivariate analysis showed that a longer operating time and not receiving topical tetracycline were independent risk factors for development of SSI. CONCLUSION: Administration of topical tetracycline for 48 hours postoperatively is an effective way of preventing SSI after oral cancer surgery.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Carcinoma de Células Escamosas/cirurgia
Neoplasias Bucais/cirurgia
Infecção da Ferida Cirúrgica/prevenção & controle
Tetraciclina/uso terapêutico
[Mh] Termos MeSH secundário: Administração Tópica
Idoso
Antibacterianos/administração & dosagem
Feminino
Seres Humanos
Masculino
Projetos Piloto
Retalhos Cirúrgicos
Tetraciclina/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180115
[Lr] Data última revisão:
180115
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008891


  6 / 15943 MEDLINE  
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[PMID]:29020098
[Au] Autor:Kromann S; Kudirkiene E; Li L; Thoefner I; Daldorph E; Christensen JP; Meng H; Olsen RH
[Ad] Endereço:Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
[Ti] Título:Treatment with high-dose antidepressants severely exacerbates the pathological outcome of experimental Escherichia coli infections in poultry.
[So] Source:PLoS One;12(10):e0185914, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is an urgent need for novel antibiotics as the current antibiotics are losing their value due to increased resistance among clinically important bacteria. Sertraline, an on-marked anti-depressive drug, has been shown to modify bacterial activity in vitro, including increasing the susceptibility of Escherichia coli to antibiotics. The aim of the present study was to investigate if the antimicrobial activity of sertraline could be documented under clinical settings, hereunder if sertraline could potentiate the effect of tetracycline in treatment of an experimentally induced ascending infection in poultry. A total of 40 chickens were divided in four groups of 10 chickens each. All chickens were challenged with 4x103 colony forming units (CFU) of a tetracycline resistant E. coli strain using a surgical infection model, and subsequently treated with either high-dose sertraline, tetracycline, a combination hereof or received no treatment. Seven days post challenge all birds were submitted to necropsy and scored pathologically for lesions. The average lesion scores were significantly higher (P<0.05) in the groups that were treated with high-dose sertraline or high-dose sertraline combined with tetracycline. In conclusion high-dose treatments (four times the maximum therapeutic dose for treating human depression) with sertraline as an adjuvant for treatment of antibiotic resistant E. coli infections exacerbate the pathological outcome of infection in chickens.
[Mh] Termos MeSH primário: Antidepressivos/uso terapêutico
Galinhas/microbiologia
Progressão da Doença
Infecções por Escherichia coli/tratamento farmacológico
Infecções por Escherichia coli/microbiologia
Escherichia coli/fisiologia
Doenças das Aves Domésticas/tratamento farmacológico
Doenças das Aves Domésticas/microbiologia
[Mh] Termos MeSH secundário: Animais
Antidepressivos/farmacologia
Peso Corporal/efeitos dos fármacos
Contagem de Colônia Microbiana
Relação Dose-Resposta a Droga
Sinergismo Farmacológico
Escherichia coli/efeitos dos fármacos
Escherichia coli/crescimento & desenvolvimento
Tubas Uterinas/efeitos dos fármacos
Tubas Uterinas/microbiologia
Feminino
Imuno-Histoquímica
Fígado/patologia
Sertralina/farmacologia
Sertralina/uso terapêutico
Tetraciclina/farmacologia
Tetraciclina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); F8VB5M810T (Tetracycline); QUC7NX6WMB (Sertraline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185914


  7 / 15943 MEDLINE  
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[PMID]:28846777
[Au] Autor:Blanco AR; Nostro A; D'Angelo V; D'Arrigo M; Mazzone MG; Marino A
[Ad] Endereço:SIFI SpA, Aci S. Antonio, Catania, Italy.
[Ti] Título:Efficacy of a Fixed Combination of Tetracycline, Chloramphenicol, and Colistimethate Sodium for Treatment of Candida albicans Keratitis.
[So] Source:Invest Ophthalmol Vis Sci;58(10):4292-4298, 2017 Aug 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To evaluate the antifungal activity of a fixed antibiotic combination (AC) containing tetracycline (TET), chloramphenicol (CAF), and colistimethate sodium (CS). Methods: In vitro: Candida ATCC and clinical strains were used. The minimum inhibitory concentrations (MICs) of AC and of each antibiotic were determined. Fluconazole (FLC) was tested for comparison. Time-killing curves of selected strains were performed. Ex vivo keratitis: corneas were injected intrastromally with the selected strains. After the injection, corneas were divided into groups of treatments: AC, FLC, or saline. Then, the tissues were analyzed for colony-forming units per gram (CFU/g). Propidium iodide (PI) and MitoTracker (MTR) staining were used to investigate the mode of action. Results: Values of MIC required to inhibit the growth of 90% of organisms for the antibiotics alone were higher than FLC. However, their activity was enhanced when used in combination against Candida yeasts. Time-killing curves showed that at 24 hours, AC reduced the load of both strains of approximately 1 Log10 CFU/g compared with the initial inoculum (P < 0.0001). This effect was also significant versus FLC. In ex vivo, AC was effective in decreasing the loads of both strains by 4 Log10 CFU/g with respect to the control. Moreover, it showed higher activity than FLC against Candida albicans ATCC 10231 (1 Log10 CFU/g, P < 0.01 versus control). PI staining demonstrated that CS changed the membrane's permeability, whereas MTR staining demonstrated that TET or CAF altered mitochondrial function. The cells treated with AC and stained showed both effects. Conclusions: In this study, AC showed antifungal efficacy versus Candida spp.; this activity can be due to the synergistic effects of antibiotics in it.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Candida albicans/efeitos dos fármacos
Candidíase/tratamento farmacológico
Cloranfenicol/uso terapêutico
Colistina/análogos & derivados
Úlcera da Córnea/tratamento farmacológico
Infecções Oculares Fúngicas/tratamento farmacológico
Tetraciclina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Candida albicans/isolamento & purificação
Candidíase/microbiologia
Colistina/uso terapêutico
Contagem de Colônia Microbiana
Úlcera da Córnea/microbiologia
Combinação de Medicamentos
Farmacorresistência Fúngica
Sinergismo Farmacológico
Infecções Oculares Fúngicas/microbiologia
Testes de Sensibilidade Microbiana
Soluções Oftálmicas
Coelhos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Drug Combinations); 0 (Ophthalmic Solutions); 66974FR9Q1 (Chloramphenicol); DL2R53P963 (colistinmethanesulfonic acid); F8VB5M810T (Tetracycline); Z67X93HJG1 (Colistin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.17-22047


  8 / 15943 MEDLINE  
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[PMID]:28841421
[Au] Autor:Tintino SR; Morais-Tintino CD; Campina FF; Costa MDS; Menezes IRA; de Matos YMLS; Calixto-Júnior JT; Pereira PS; Siqueira-Junior JP; Leal-Balbino TC; Coutinho HDM; Balbino VQ
[Ad] Endereço:Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry/CCBS/URCA, Brazil.
[Ti] Título:Tannic acid affects the phenotype of Staphylococcus aureus resistant to tetracycline and erythromycin by inhibition of efflux pumps.
[So] Source:Bioorg Chem;74:197-200, 2017 Oct.
[Is] ISSN:1090-2120
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The widespread use of antibiotics created selective pressure for the emergence of strains that would persist despite antibiotic toxicity. The bacterial resistance mechanisms are several, with efflux pumps being one of the main ones. These pumps are membrane proteins with the function of removing antibiotics from the cell cytoplasm. Due to this importance, the aim of this work was to evaluate the inhibitory effect of tannic acid against efflux pumps expressed by the Staphylococcus aureus RN4220 and IS-58 strains. The efflux pump inhibition was assayed using a sub-inhibitory concentration of efflux pump standard inhibitors and tannic acid (MIC/8), observing their capacity to decrease the MIC of Ethidium bromide (EtBr) and antibiotics due the possible inhibitory effect of these substances. The MICs of EtBr and antibiotics were significantly different in the presence of tannic acid, indicating the inhibitory effect of this product against efflux pumps of both strains. These results indicate the possible usage of tannic acid asan inhibitor and an adjuvant in the antibiotic therapy against multidrug resistant bacteria (MDR).
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Farmacorresistência Bacteriana/efeitos dos fármacos
Eritromicina/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Taninos/farmacologia
Tetraciclina/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Relação Dose-Resposta a Droga
Farmacorresistência Bacteriana/genética
Eritromicina/química
Testes de Sensibilidade Microbiana
Estrutura Molecular
Fenótipo
Staphylococcus aureus/genética
Relação Estrutura-Atividade
Taninos/química
Tetraciclina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Tannins); 63937KV33D (Erythromycin); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170826
[St] Status:MEDLINE


  9 / 15943 MEDLINE  
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[PMID]:28797073
[Au] Autor:Chen HR; Rairat T; Loh SH; Wu YC; Vickroy TW; Chou CC
[Ad] Endereço:Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
[Ti] Título:Assessment of veterinary drugs in plants using pharmacokinetic approaches: The absorption, distribution and elimination of tetracycline and sulfamethoxazole in ephemeral vegetables.
[So] Source:PLoS One;12(8):e0183087, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study was carried out to demonstrate novel use of pharmacokinetic approaches to characterize drug behaviors/movements in the vegetables with implications to food safety. The absorption, distribution, metabolism and most importantly, the elimination of tetracycline (TC) and sulfamethoxazole (SMX) in edible plants Brassica rapa chinensis and Ipomoea aquatica grown hydroponically were demonstrated and studied using non-compartmental pharmacokinetic analysis. The results revealed drug-dependent and vegetable-dependent pharmacokinetic differences and indicated that ephemeral vegetables could have high capacity accumulating antibiotics (up to 160 µg g-1 for TC and 38 µg g-1 for SMX) within hours. TC concentration in the root (Cmax) could reach 11 times higher than that in the cultivation fluid and 3-28 times higher than the petioles/stems. Based on the volume of distribution (Vss), SMX was 3-6 times more extensively distributed than TC. Both antibiotics showed evident, albeit slow elimination phase with elimination half-lives ranging from 22 to 88 hours. For the first time drug elimination through the roots of a plant was demonstrated, and by viewing the root as a central compartment and continuous infusion without a loading dose as drug administration mode, it is possible to pharmacokinetically monitor the movement of antibiotics and their fate in the vegetables with more detailed information not previously available. Phyto-pharmacokinetic could be a new area worth developing new models for the assessment of veterinary drugs in edible plants.
[Mh] Termos MeSH primário: Anti-Infecciosos/metabolismo
Brassica rapa/metabolismo
Spinacia oleracea/metabolismo
Sulfametoxazol/metabolismo
Tetraciclina/metabolismo
Verduras/metabolismo
Drogas Veterinárias/metabolismo
[Mh] Termos MeSH secundário: Anti-Infecciosos/análise
Contaminação de Alimentos/análise
Sulfametoxazol/análise
Tetraciclina/análise
Drogas Veterinárias/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Veterinary Drugs); F8VB5M810T (Tetracycline); JE42381TNV (Sulfamethoxazole)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183087


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[PMID]:28792530
[Au] Autor:Wang H; Chu Y; Fang C; Huang F; Song Y; Xue X
[Ad] Endereço:Key Laboratory of Recycling and Eco-treatment of Waste Biomass of Zhejiang Province, Zhejiang University of Science and Technology, Hangzhou, Zhejiang, China.
[Ti] Título:Sorption of tetracycline on biochar derived from rice straw under different temperatures.
[So] Source:PLoS One;12(8):e0182776, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Biochars produced from the pyrolysis of waste biomass under limited oxygen conditions could serve as adsorbents in environmental remediation processes. Biochar samples derived from rice straw that were pyrolyzed at 300 (R300), 500 (R500) and 700°C (R700) were used as adsorbents to remove tetracycline from an aqueous solution. Both the Langmuir and Freundlich models fitted the adsorption data well (R2 > 0.919). The adsorption capacity increased with pyrolysis temperature. The R500 and R700 samples exhibited relative high removal efficiencies across a range of initial tetracycline concentrations (0.5mg/L-32mg/L) with the maximum (92.8%-96.7%) found for adsorption on R700 at 35°C. The relatively high surface area of the R700 sample and π-π electron-donor acceptor contributed to the high adsorption capacities. A thermodynamic analysis indicated that the tetracycline adsorption process was spontaneous and endothermic. The pH of solution was also found to influence the adsorption processes; the maximum adsorption capacity occurred at a pH of 5.5. These experimental results highlight that biochar derived from rice straw is a promising candidate for low-cost removal of tetracycline from water.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Tetraciclina/química
[Mh] Termos MeSH secundário: Adsorção
Recuperação e Remediação Ambiental
Concentração de Íons de Hidrogênio
Modelos Lineares
Modelos Químicos
Oryza/química
Porosidade
Soluções/química
Espectroscopia de Infravermelho com Transformada de Fourier
Temperatura Ambiente
Água/química
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solutions); 0 (Water Pollutants, Chemical); 0 (biochar); 059QF0KO0R (Water); 16291-96-6 (Charcoal); F8VB5M810T (Tetracycline)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182776



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