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[PMID]:28814399
[Au] Autor:White WS; Zhou Y; Crane A; Dixon P; Quadt F; Flendrig LM
[Ad] Endereço:Departments of Food Science and Human Nutrition and wswhite@iastate.edu.
[Ti] Título:Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables.
[So] Source:Am J Clin Nutr;106(4):1041-1051, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previously, we showed that vegetable oil is necessary for carotenoid absorption from salad vegetables. Research is needed to better define the dose effect and its interindividual variation for carotenoids and fat-soluble vitamins. The objective was to model the dose-response relation between the amount of soybean oil in salad dressing and the absorption of ) carotenoids, phylloquinone, and tocopherols in salad vegetables and ) retinyl palmitate formed from the provitamin A carotenoids. Women ( = 12) each consumed 5 vegetable salads with salad dressings containing 0, 2, 4, 8, or 32 g soybean oil. Blood was collected at selected time points. The outcome variables were the chylomicron carotenoid and fat-soluble vitamin area under the curve (AUC) and maximum content in the plasma chylomicron fraction ( ). The individual-specific and group-average dose-response relations were investigated by fitting linear mixed-effects random coefficient models. Across the entire 0-32-g range, soybean oil was linearly related to the chylomicron AUC and values for α-carotene, lycopene, phylloquinone, and retinyl palmitate. Across 0-8 g of soybean oil, there was a linear increase in the chylomicron AUC and values for ß-carotene. Across a more limited 0-4-g range of soybean oil, there were minor linear increases in the chylomicron AUC for lutein and α- and total tocopherol. Absorption of all carotenoids and fat-soluble vitamins was highest with 32 g oil ( < 0.002). For 32 g oil, the interindividual rank order of the chylomicron AUCs was consistent across the carotenoids and fat-soluble vitamins ( < 0.0001). Within the linear range, the average absorption of carotenoids and fat-soluble vitamins could be largely predicted by the soybean oil effect. However, the effect varied widely, and some individuals showed a negligible response. There was a global soybean oil effect such that those who absorbed more of one carotenoid and fat-soluble vitamin also tended to absorb more of the others. This trial was registered at clinicaltrials.gov as NCT02867488.
[Mh] Termos MeSH primário: Carotenoides/farmacocinética
Dieta
Absorção Intestinal/efeitos dos fármacos
Óleo de Soja/administração & dosagem
Verduras/química
Vitamina A/análogos & derivados
Vitaminas/farmacocinética
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Disponibilidade Biológica
Carotenoides/sangue
Quilomícrons
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Luteína/sangue
Luteína/farmacocinética
Modelos Biológicos
Solubilidade
Óleo de Soja/farmacologia
Tocoferóis/sangue
Tocoferóis/farmacocinética
Vitamina A/sangue
Vitamina K 1/sangue
Vitamina K 1/farmacocinética
Vitaminas/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Chylomicrons); 0 (Vitamins); 11103-57-4 (Vitamin A); 1D1K0N0VVC (retinol palmitate); 36-88-4 (Carotenoids); 45XWE1Z69V (alpha-carotene); 8001-22-7 (Soybean Oil); 84-80-0 (Vitamin K 1); R0ZB2556P8 (Tocopherols); SB0N2N0WV6 (lycopene); X72A60C9MT (Lutein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.153635


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[PMID]:28699238
[Au] Autor:Zhang R; Ma M; Dong G; Yao RR; Li JH; Zheng QD; Dong YY; Ma H; Gao DM; Cui JF; Ren ZG; Chen RX
[Ad] Endereço:Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
[Ti] Título:Increased matrix stiffness promotes tumor progression of residual hepatocellular carcinoma after insufficient heat treatment.
[So] Source:Cancer Sci;108(9):1778-1786, 2017 Sep.
[Is] ISSN:1349-7006
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aggravated behaviors of hepatocellular carcinoma (HCC) will occur after inadequate thermal ablation. However, its underlying mechanisms are not fully understood. Here, we assessed whether the increased matrix stiffness after thermal ablation could promote the progression of residual HCC. Heat-treated residual HCC cells were cultured on tailorable 3D gel with different matrix stiffness, simulating the changed physical environment after thermal ablation, and then the mechanical alterations of matrix stiffness on cell phenotypes were explored. Increased stiffness was found to significantly promote the proliferation of the heat-treated residual HCC cells when the cells were cultured on stiffer versus soft supports, which was associated with stiffness-dependent regulation of ERK phosphorylation. Heat-exposed HCC cells cultured on stiffer supports showed enhanced motility. More importantly, vitamin K1 reduced stiffness-dependent residual HCC cell proliferation by inhibiting ERK phosphorylation and suppressed the in vivo tumor growth, which was further enhanced by combining with sorafenib. Increased matrix stiffness promotes the progression of heat-treated residual HCC cells, proposing a new mechanism of an altered biomechanical environment after thermal ablation accelerates HCC development. Vitamin K1 plus sorafenib can reverse this protumor effect.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/patologia
Matriz Extracelular/patologia
Neoplasias Hepáticas Experimentais/patologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Carcinoma Hepatocelular/terapia
Linhagem Celular Tumoral
Movimento Celular
Proliferação Celular
Terapia Combinada
Progressão da Doença
Ativação Enzimática
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Seres Humanos
Hipertermia Induzida
Neoplasias Hepáticas Experimentais/terapia
Masculino
Camundongos Endogâmicos BALB C
Camundongos Nus
Neoplasia Residual
Células-Tronco Neoplásicas/fisiologia
Niacinamida/análogos & derivados
Niacinamida/farmacologia
Compostos de Fenilureia/farmacologia
Transdução de Sinais
Vitamina K 1/farmacologia
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Phenylurea Compounds); 25X51I8RD4 (Niacinamide); 84-80-0 (Vitamin K 1); 9ZOQ3TZI87 (sorafenib); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1111/cas.13322


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[PMID]:28669508
[Au] Autor:Makita H; Rohani L; Zhao N; Hastings G
[Ad] Endereço:Department of Physics and Astronomy, Georgia State University, Atlanta, GA 30303, USA.
[Ti] Título:Quinones in the A binding site in photosystem I studied using time-resolved FTIR difference spectroscopy.
[So] Source:Biochim Biophys Acta;1858(9):804-813, 2017 09.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Time-resolved step-scan FTIR difference spectroscopy at low temperature (77 K) has been used to study photosystem I particles with phylloquinone (2-methyl-3-phytyl-1,4-naphthaquinone) and menadione (2-methyl-1,4-naphthaquinone) incorporated into the A binding site. By subtracting spectra for PSI with phylloquinone incorporated from spectra for PSI with menadione incorporated a (menadione - phylloquinone) double difference spectrum was constructed. In the double difference spectrum bands associated with protein vibrational modes effectively cancel, and the bands in the spectrum are primarily associated with the neutral and reduced states of the two quinones in the A binding site. To aid in the assignment of bands in the experimental double difference spectrum, a double difference spectrum was calculated using three-layer ONIOM methods. The calculated and experimental spectra agree well, allowing unambiguous band assignments to be made. The ONIOM calculations show that both quinones in the A binding site are similarly oriented, with only a single hydrogen bond between the C =O quinone carbonyl group and the backbone NH group of a leucine residue. For the semi-quinone species, but not for the neutral species, this hydrogen bond appears to be very strong. Finally, we have for the first time been able to unmask and identify infrared difference bands associated with neutral naphthoquinone species occupying the A binding site in PSI.
[Mh] Termos MeSH primário: Complexo de Proteína do Fotossistema I/química
Quinonas/química
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
Vitamina K 1/metabolismo
[Mh] Termos MeSH secundário: Sítios de Ligação
Modelos Moleculares
Complexo de Proteína do Fotossistema I/metabolismo
Ligação Proteica
Conformação Proteica
Synechocystis/genética
Synechocystis/metabolismo
Vitamina K 2/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Photosystem I Protein Complex); 0 (Quinones); 11032-49-8 (Vitamin K 2); 84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE


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[PMID]:28566528
[Au] Autor:Harshman SG; Finnan EG; Barger KJ; Bailey RL; Haytowitz DB; Gilhooly CH; Booth SL
[Ad] Endereço:Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
[Ti] Título:Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES.
[So] Source:J Nutr;147(7):1308-1313, 2017 Jul.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phylloquinone is the most abundant form of vitamin K in US diets. Green vegetables are considered the predominant dietary source of phylloquinone. As our food supply diversifies and expands, the food groups that contribute to phylloquinone intake are also changing, which may change absolute intakes. Thus, it is important to identify the contributors to dietary vitamin K estimates to guide recommendations on intakes and food sources. The purpose of this study was to estimate ) the amount of phylloquinone consumed in the diet of US adults, ) to estimate the contribution of different food groups to phylloquinone intake in individuals with a high or low vegetable intake (≥2 or <2 cups vegetables/d), and ) to characterize the contribution of different mixed dishes to phylloquinone intake. Usual phylloquinone intake was determined from NHANES 2011-2012 (≥20 y old; 2092 men and 2214 women) and the National Cancer Institute Method by utilizing a complex, stratified, multistage probability-cluster sampling design. On average, 43.0% of men and 62.5% of women met the adequate intake (120 and 90 µg/d, respectively) for phylloquinone, with the lowest self-reported intakes noted among men, especially in the older age groups (51-70 and ≥71 y). Vegetables were the highest contributor to phylloquinone intake, contributing 60.0% in the high-vegetable-intake group and 36.1% in the low-vegetable-intake group. Mixed dishes were the second-highest contributor to phylloquinone intake, contributing 16.0% in the high-vegetable-intake group and 28.0% in the low-vegetable-intake group. Self-reported phylloquinone intakes from updated food composition data applied to NHANES 2011-2012 reveal that fewer men than women are meeting the current adequate intake. Application of current food composition data confirms that vegetables continue to be the primary dietary source of phylloquinone in the US diet. However, mixed dishes and convenience foods have emerged as previously unrecognized but important contributors to phylloquinone intake in the United States, which challenges the assumption that phylloquinone intake is a marker of a healthy diet. These findings emphasize the need for the expansion of food composition databases that consider how mixed dishes are compiled and defined.
[Mh] Termos MeSH primário: Inquéritos Nutricionais
Verduras/química
Vitamina K 1/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Estados Unidos
Vitamina K 1/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.248179


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[PMID]:28535134
[Au] Autor:Lawson C; O'Brien M; McMichael M
[Ad] Endereço:From the University of Illinois, Urbana, Illinois.
[Ti] Título:Upper Airway Obstruction Secondary to Anticoagulant Rodenticide Toxicosis in Five Dogs.
[So] Source:J Am Anim Hosp Assoc;53(4):236-241, 2017 Jul/Aug.
[Is] ISSN:0587-2871
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Five dogs were presented with clinical signs compatible with upper airway obstruction, including stridor, stertor, coughing, gagging, and varying degrees of respiratory distress. All dogs had radiographic findings of soft tissue opacity in the area of the pharynx, larynx, or trachea, and several had narrowing of the tracheal lumen. Coagulation abnormalities (prolonged prothrombin time, activated partial thromboplastin time) were present in the four dogs that underwent testing. Four of five dogs were treated for the coagulopathy, presumably due to anticoagulant rodenticide toxicosis, and survived to discharge.Upper airway obstruction is an unusual presentation for anticoagulant rodenticide toxicosis in dogs. Raising the index of suspicion for this treatable condition may help clinicians to identify this sooner.
[Mh] Termos MeSH primário: Obstrução das Vias Respiratórias/veterinária
Doenças do Cão/induzido quimicamente
Hemorragia/veterinária
Envenenamento/veterinária
Rodenticidas/toxicidade
[Mh] Termos MeSH secundário: Obstrução das Vias Respiratórias/induzido quimicamente
Animais
Antídotos/administração & dosagem
Antídotos/uso terapêutico
Cães
Evolução Fatal
Feminino
Hemorragia/induzido quimicamente
Hemorragia/complicações
Hemorragia/tratamento farmacológico
Masculino
Envenenamento/patologia
Vitamina K 1/administração & dosagem
Vitamina K 1/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidotes); 0 (Rodenticides); 84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE
[do] DOI:10.5326/JAAHA-MS-6658


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[PMID]:28494067
[Au] Autor:Camacho-Barcia ML; Bulló M; Garcia-Gavilán JF; Ruiz-Canela M; Corella D; Estruch R; Fitó M; García-Layana A; Arós F; Fiol M; Lapetra J; Serra-Majem L; Pintó X; García-Arellano A; Vinyoles E; Sorli JV; Salas-Salvadó J
[Ad] Endereço:Human Nutrition Unit, Biochemistry and Biotechnology Department, University Hospital of Sant Joan de Reus, Reus, Spain.
[Ti] Título:Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial.
[So] Source:JAMA Ophthalmol;135(6):657-661, 2017 Jun 01.
[Is] ISSN:2168-6173
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Cataract, one of the most frequent causes of blindness in developed countries, is strongly associated with aging. The exact mechanisms underlying cataract formation are still unclear, but growing evidence suggests a potential role of inflammatory and oxidative processes. Therefore, antioxidant and anti-inflammatory factors of the diet, such as vitamin K1, could play a protective role. Objective: To examine the association between dietary vitamin K1 intake and the risk of incident cataracts in an elderly Mediterranean population. Design, Setting, and Participants: A prospective analysis was conducted in 5860 participants from the Prevención con Dieta Mediterránea Study, a randomized clinical trial executed between 2003 and 2011. Participants were community-dwelling men (44.2%) and women (55.8%), and the mean (SD) age was 66.3 (6.1) years. Main Outcomes and Measures: Dietary vitamin K1 intake was evaluated using a validated food frequency questionnaire. The time to the cataract event was calculated as the time between recruitment and the date of the occurrence to cataract surgery, the time to the last visit of the follow-up, date of death, or the end of the study. Hazard ratios and 95% CIs for cataract incidence were estimated with a multivariable Cox proportional hazards model. Results: Participants were community-dwelling men (44.2%; n = 868) and women (55.8%; n = 1086), and the mean (SD) age was 66.3 (6.1) years. After a median of 5.6 years follow-up, we documented a total of 768 new cataracts. Participants in the highest tertile of dietary vitamin K1 intake had a lower risk of cataracts than those in the lowest tertile (hazard ratio, 0.71; 95% CI, 0.58-0.88; P = .002), after adjusting for potential confounders. Conclusions and Relevance: High intake of dietary vitamin K1 was associated with a reduced risk of cataracts in an elderly Mediterranean population even after adjusting by other potential confounders. Trial Registration: isrctn.org: ISRCTN35739639.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/prevenção & controle
Extração de Catarata/estatística & dados numéricos
Catarata/epidemiologia
Suplementos Nutricionais
Medição de Risco
Vitamina K 1/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Catarata/etiologia
Feminino
Seres Humanos
Incidência
Masculino
Meia-Idade
Estudos Prospectivos
Fatores de Risco
Espanha/epidemiologia
Vitaminas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Vitamins); 84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1001/jamaophthalmol.2017.1076


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[PMID]:28356433
[Au] Autor:Shea MK; Booth SL; Weiner DE; Brinkley TE; Kanaya AM; Murphy RA; Simonsick EM; Wassel CL; Vermeer C; Kritchevsky SB; Health ABC Study
[Ad] Endereço:USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA; kyla.shea@tufts.edu.
[Ti] Título:Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC).
[So] Source:J Nutr;147(5):888-895, 2017 May.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A role for vitamin K in coronary artery calcification (CAC), a subclinical manifestation of cardiovascular disease (CVD), has been proposed because vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein (MGP), are present in vascular tissue. Observational studies found that low circulating phylloquinone (vitamin K-1) was associated with increased CAC progression, especially in persons treated for hypertension. It is unknown whether hypertension treatment modifies this putative role of vitamin K in clinical CVD risk. We determined the association between vitamin K status and incident clinical CVD in older adults in the Health ABC (Health, Aging, and Body Composition Study) and whether the association differed by hypertension treatment status. Plasma phylloquinone was measured in 1061 participants free of CVD (70-79 y of age, 58% women, 39% black). Plasma uncarboxylated MGP [(dp)ucMGP] was measured in a subset of 635 participants. Multivariate Cox models estimated the HR for incident CVD over 12.1 follow-up years. Effect modification by hypertension was tested with the use of interaction terms. Neither low plasma phylloquinone (<0.2 nmol/L) nor elevated (dp)ucMGP (≥574 pmol/L) was significantly associated with incident CVD [respective HRs (95% CIs): 1.27 (0.75, 2.13) and 1.02 (0.72, 1.45)]. In participants treated for hypertension ( = 489; 135 events), low plasma phylloquinone was associated with higher CVD risk overall (HR: 2.94; 95% CI: 1.41, 6.13). In those with untreated hypertension ( = 153; 48 events) and without hypertension ( = 418; 92 events), low plasma phylloquinone was not associated with incident CVD. The association between high (dp)ucMGP did not differ by hypertension treatment status ( -interaction = 0.72). Vitamin K status was not significantly associated with CVD risk overall, but low plasma phylloquinone was associated with a higher CVD risk in older adults treated for hypertension. Additional evidence from larger clinical studies is needed to clarify the importance of vitamin K to CVD in persons treated for hypertension, a segment of the population at high risk of clinical CVD events.
[Mh] Termos MeSH primário: Deficiência de Vitaminas/complicações
Doenças Cardiovasculares/etiologia
Hipertensão/complicações
Vitamina K 1/sangue
[Mh] Termos MeSH secundário: Idoso
Envelhecimento
Anti-Hipertensivos/uso terapêutico
Deficiência de Vitaminas/sangue
Composição Corporal
Calcinose/etiologia
Proteínas de Ligação ao Cálcio/sangue
Doenças Cardiovasculares/sangue
Proteínas da Matriz Extracelular/sangue
Feminino
Seres Humanos
Hipertensão/sangue
Hipertensão/tratamento farmacológico
Masculino
Infarto do Miocárdio/etiologia
Isquemia Miocárdica/etiologia
Modelos de Riscos Proporcionais
Fatores de Risco
Acidente Vascular Cerebral/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Calcium-Binding Proteins); 0 (Extracellular Matrix Proteins); 0 (matrix Gla protein); 84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.3945/jn.117.249375


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[PMID]:28284080
[Au] Autor:Torkashvand M; Gholivand MB; Taherpour AA; Boochani A; Akhtar A
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
[Ti] Título:Introduction of a carbon paste electrode based on nickel carbide for investigation of interaction between warfarin and vitamin K1.
[So] Source:J Pharm Biomed Anal;139:156-164, 2017 May 30.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this paper a novel electrochemical sensor based on nickel carbide (Ni C) nanoparticles as a new modifier was constructed. Ni C nanoparticle was synthesized and characterized by scanning electron microscopy, X-ray diffraction and first-principles study. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) studies confirmed the electrode modification. Afterwards, the new electrode for the first time was used for interaction study between vitamin K1 and warfarin as an anticoagulant drug by differential pulse voltammetry. The adduct formation between the drug and vitamin K1 was improved by decreasing in anodic peak current of warfarin in the presence of different amounts of vitamin K1. The binding constant between warfarin and vitamin K1 was obtained by voltammetric and UV-vis and fluorescence spectroscopic methods. The molecular modeling method was also performed to explore the structural features and binding mechanism of warfarin to vitamin K1. The different aspects of modeling of vitamin K1 and warfarin and their adduct structures confirmed the adduct formation by hydrogen bonding.
[Mh] Termos MeSH primário: Carbono/química
Nanopartículas Metálicas/química
Modelos Moleculares
Níquel/química
Vitamina K 1/metabolismo
Varfarina/metabolismo
[Mh] Termos MeSH secundário: Interações Medicamentosas/fisiologia
Eletrodos
Vitamina K 1/análise
Varfarina/análise
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (nickel carbide); 5Q7ZVV76EI (Warfarin); 7440-44-0 (Carbon); 7OV03QG267 (Nickel); 84-80-0 (Vitamin K 1)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:28197787
[Au] Autor:Schimanski CC; Staib F; Göhler T; Hebart H; Heike M; Neise M; Rudi J; Geer T; Dingeldein G; Lang C; Ehscheidt P; Flohr T; Josten KM; Karthaus M; Schmittel A; Wierecky J; Boller E; Indorf M; Wörns MA; Galle PR; Moehler M
[Ad] Endereço:Medizinische Klinik II, Klinikum Darmstadt GmbH, Grafenstraße 9, 64283, Darmstadt, Germany. Carl.Schimanski@mail.klinikum-darmstadt.de.
[Ti] Título:Dermatux: phase IV trial of Cetuximab plus FOLFIRI in first-line metastatic colorectal cancer receiving a pre-defined skin care.
[So] Source:J Cancer Res Clin Oncol;143(6):1023-1034, 2017 Jun.
[Is] ISSN:1432-1335
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Cetuximab-induced skin rash Gd3+ occurs in ≥16% patients (pts) (Heinemann et al., Lancet Oncol 15(10):1065-1075, 2014; Van Cutsem et al. J Clin Oncol 27(19):3117-25; 2009b). Survival, response, and toxicity parameters were re-evaluated under a pre-defined skin prophylaxis consistent of vitamin K1 ointment and oral doxycycline. METHODS: This is a national, multicenter, phase 4, first-line mCRC (K-RAS wt) trial. Pts received irinotecan 180 mg/m² (d1), FA 400 mg/m² (d1), 5-FU 400 mg/m² (d1), 5-FU 2400 mg/m² (d1-2), and cetuximab [400 mg/m² (d1), and then 250 mg/m² qw], prophylactic 0.1% vitamin K1 ointment qd, and oral doxycycline 100 mg bid. PRIMARY OBJECTIVE: 1-year PFS rate; secondary objectives: skin side-effects (grade, onset), objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) time, and overall survival (OS) time and safety. RESULTS: Twenty centers recruited 55 patients. Recruitment started Q1 2011 and ended Q3 2013 due to slow accrual. Characteristics were in line with CRYSTAL trial except for age and colonic location. 1-year PFS rate was 25.9%, mOS 21.8 months (m), and mPFS 8.5 m. ORR was 63.0%, DCR 77.8%. Rash Gd2+ occurred in 42.6% [median onset was 4.0 weeks (w)]; paronychia Gd2+ occurred in 22.2% (median onset 15.4w.); skin fissures Gd2+ occurred in 31.5% (median onset 19.9 weeks) 7% pts abandoned cetuximab treatment due to toxicity. CONCLUSION: Our data reveal encouraging improvements in skin reactions and their time to occurrence due to a pre-defined skin care.
[Mh] Termos MeSH primário: Adenocarcinoma/tratamento farmacológico
Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem
Camptotecina/análogos & derivados
Cetuximab/administração & dosagem
Cetuximab/efeitos adversos
Neoplasias Colorretais/tratamento farmacológico
Erupção por Droga/prevenção & controle
Higiene da Pele/métodos
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Administração Cutânea
Administração Oral
Adulto
Idoso
Idoso de 80 Anos ou mais
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos
Camptotecina/administração & dosagem
Camptotecina/efeitos adversos
Quimioprevenção/métodos
Neoplasias Colorretais/patologia
Doxiciclina/administração & dosagem
Exantema/induzido quimicamente
Exantema/prevenção & controle
Feminino
Fluoruracila/administração & dosagem
Fluoruracila/efeitos adversos
Seres Humanos
Leucovorina/administração & dosagem
Leucovorina/efeitos adversos
Masculino
Meia-Idade
Terapia Neoadjuvante
Metástase Neoplásica
Pomadas
Resultado do Tratamento
Vitamina K 1/administração & dosagem
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE IV; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Ointments); 84-80-0 (Vitamin K 1); N12000U13O (Doxycycline); PQX0D8J21J (Cetuximab); Q573I9DVLP (Leucovorin); U3P01618RT (Fluorouracil); XT3Z54Z28A (Camptothecin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1007/s00432-017-2344-3


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[PMID]:28065270
[Au] Autor:Tie JK; Stafford DW
[Ad] Endereço:University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address: jktie@email.unc.edu.
[Ti] Título:Functional Study of the Vitamin K Cycle Enzymes in Live Cells.
[So] Source:Methods Enzymol;584:349-394, 2017.
[Is] ISSN:1557-7988
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vitamin K-dependent carboxylation, an essential posttranslational modification catalyzed by gamma-glutamyl carboxylase, is required for the biological functions of proteins that control blood coagulation, vascular calcification, bone metabolism, and other important physiological processes. Concomitant with carboxylation, reduced vitamin K (KH ) is oxidized to vitamin K epoxide (KO). KO must be recycled back to KH by the enzymes vitamin K epoxide reductase and vitamin K reductase in a pathway known as the vitamin K cycle. Our current knowledge about the enzymes of the vitamin K cycle is mainly based on in vitro studies of each individual enzymes under artificial conditions, which are of limited usefulness in understanding how the complex carboxylation process is carried out in the physiological environment. In this chapter, we review the current in vitro activity assays for vitamin K cycle enzymes. We describe the rationale, establishment, and application of cell-based assays for the functional study of these enzymes in the native cellular milieu. In these cell-based assays, different vitamin K-dependent proteins were designed and stably expressed in mammalian cells as reporter proteins to accommodate the readily used enzyme-linked immunosorbent assay for carboxylation efficiency evaluation. Additionally, recently emerged genome-editing techniques TALENs and CRISPR-Cas9 were used to knock out the endogenous enzymes in the reporter cell lines to eliminate the background. These cell-based assays are easy to scale up for high-throughput screening of inhibitors of vitamin K cycle enzymes and have been successfully used to clarify the genotypes and their clinical phenotypes of enzymes of the vitamin K cycle.
[Mh] Termos MeSH primário: Ensaios Enzimáticos/métodos
NAD(P)H Desidrogenase (Quinona)/química
Vitamina K Epóxido Redutases/química
Vitamina K/química
[Mh] Termos MeSH secundário: Animais
Ensaio de Imunoadsorção Enzimática/métodos
Seres Humanos
Processamento de Proteína Pós-Traducional/genética
Vitamina K/antagonistas & inibidores
Vitamina K/metabolismo
Vitamina K 1/análogos & derivados
Vitamina K 1/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
12001-79-5 (Vitamin K); 25486-55-9 (vitamin K1 oxide); 572-96-3 (vitamin K1 hydroquinone); 84-80-0 (Vitamin K 1); EC 1.17.4.4 (Vitamin K Epoxide Reductases); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE



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