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[PMID]:28886495
[Au] Autor:Chen XM; Zhao Y; Ma YY; Zhu LJ; Yang TX; Wei ZM; Dong YL; Wei QB
[Ad] Endereço:College of Life Science, Northeast Agricultural University, Harbin 150030, China.
[Ti] Título:Assessing the environmental impact of phenanthrene in different types of land use based on the binding characteristics with dissolved organic matter.
[So] Source:Ecotoxicol Environ Saf;147:394-400, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The binding characteristics of phenanthrene with dissolved organic matter (DOM) were studied by the excitation emission matrix fluorescence spectroscopy with parallel factor analysis in four types of land use which derived from forest (F), meadow (M), cropland (C), and greenhouse (G). The results showed that the humification degree and binding characteristics of phenanthrene with DOM were distinct differences in the four soils. The binding capacities of humic-like components with phenanthrene were stronger than those of protein-like components. The log K derived from the Stern-Volmer equation significantly correlated with the humification degree of DOM (p < 0.05) in different types of land use. Besides, correlation analysis demonstrated that the potential binding index (Fk) obtained from the modified Stern-Volmer model was a more accurate parameter to describe the combination degree of DOM with phenanthrene than log K, which presented a decrease order of C > F > M > G. Therefore, the environmental impact of phenanthrene in different types of land use could be assessed deeply based on the Fk and DOM concentration.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Substâncias Húmicas/análise
Fenantrenos/análise
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Agricultura
China
Análise Fatorial
Florestas
Pradaria
Modelos Teóricos
Solubilidade
Espectrometria de Fluorescência/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Humic Substances); 0 (Phenanthrenes); 0 (Soil); 0 (Soil Pollutants); 448J8E5BST (phenanthrene)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE


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[PMID]:29441915
[Au] Autor:Cao L-; Yan M; Ma YX; Zhang BK; Fang PF; Xiang DX; Li ZH; Gong H; Deng Y; Li HD
[Ti] Título:Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation.
[So] Source:Pharmazie;71(7):394-397, 2016 Jul 07.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Isoliquiritigenin, a flavonoid found in licorice, has been considered as an antioxidive and hepato-protective agent. Recent studies have shown that a possible mechanism for triptolide-induced hepatotoxicity is related to oxidative damage induced by reactive oxygen species. This study was done to investigate the protection effect of isoliquiritigenin against triptolide-induced hepatotoxicity and the mechanism involved. An acute liver injury model was established by intraperitoneal injection of triptolide (1.0 mg · kg-1) in mice. Different doses of isoliquiritigenin (12.5, 25 and 50 mg · kg-1) were employed as protection. The activities of AST, ALT, ALP and LDH in serum and levels of GSH, GPx, SOD, CAT and MDA in liver tissue were detected. The histopathological changes of liver tissues were observed after HE staining. The protein expression of Nrf2 was detected by western blot. Pretreatment with isoliquiritigenin significantly prevented the triptolide-induced hepatotoxicity indicated by reduced activities of AST, ALT, ALP and LDH. Moreover, isoliquiritigenin pretreatment also prevented from triptolide-induced hepatotoxicity by inhibiting MDA and restoring the levels of GSH, GPx, SOD and CAT. In addition, isoliquiritigenin could attenuate histopathological changes induced by triptolide. Furthermore, the results indicated that isoliquiritigenin pretreatment caused an increase in the protein expression of Nrf2. These results indicated that isoliquiritigenin could protect against triptolide-induced hepatotoxicity via activation of the Nrf2 pathway.
[Mh] Termos MeSH primário: Chalconas/farmacologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Diterpenos/antagonistas & inibidores
Diterpenos/toxicidade
Fator 2 Relacionado a NF-E2/metabolismo
Fenantrenos/antagonistas & inibidores
Fenantrenos/toxicidade
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/patologia
Compostos de Epóxi/antagonistas & inibidores
Compostos de Epóxi/toxicidade
Fígado/efeitos dos fármacos
Fígado/metabolismo
Testes de Função Hepática
Masculino
Malondialdeído/antagonistas & inibidores
Camundongos
Camundongos Endogâmicos ICR
Fator 2 Relacionado a NF-E2/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chalcones); 0 (Diterpenes); 0 (Epoxy Compounds); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (Phenanthrenes); 0 (Protective Agents); 19ALD1S53J (triptolide); 4Y8F71G49Q (Malondialdehyde); B9CTI9GB8F (isoliquiritigenin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6535


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[PMID]:28460475
[Au] Autor:Song JM; Molla K; Anandharaj A; Cornax I; O Sullivan MG; Kirtane AR; Panyam J; Kassie F
[Ad] Endereço:Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
[Ti] Título:Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
[So] Source:Oncotarget;8(16):26927-26940, 2017 Apr 18.
[Is] ISSN:1949-2553
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Higher levels of hyaluronan (HA) and its receptors CD44 and RHAMM have been associated with poor prognosis and metastasis in NSCLC. In the current study, our goal was to define, using cellular and orthotopic lung tumor models, the role of HA-CD44/RHAMM signaling in lung carcinogenesis and to assess the potential of triptolide to block HA-CD44/RHAMM signaling and thereby suppress the development and progression of lung cancer. Triptolide reduced the viability of five non-small cell lung cancer (NSCLC) cells, the proliferation and self-renewal of pulmospheres, and levels of HA synthase 2 (HAS2), HAS3, HA, CD44, RHAMM, EGFR, Akt and ERK, but increased the cleavage of caspase 3 and PARP. Silencing of HAS2, CD44 or RHAMM induced similar effects. Addition of excess HA to the culture media completely abrogated the effects of triptolide and siRNAs targeting HAS2, CD44, or RHAMM. In an orthotopic lung cancer model in nude rats, intranasal administration of liposomal triptolide (400 µg/kg) for 8 weeks significantly reduced lung tumor growth as determined by bioluminescence imaging, lung weight measurements and gross and histopathological analysis of tumor burden. Also, triptolide suppressed expressions of Ki-67, a marker for cell proliferation, HAS2, HAS3, HA, CD44, and RHAMM in lung tumors. Overall, our results provide a strong rationale for mitigating lung cancer by targeting the HA-CD44/RHAMM signaling axis.
[Mh] Termos MeSH primário: Antineoplásicos Alquilantes/farmacologia
Diterpenos/farmacologia
Proteínas da Matriz Extracelular/metabolismo
Receptores de Hialuronatos/antagonistas & inibidores
Receptores de Hialuronatos/metabolismo
Neoplasias Pulmonares/metabolismo
Fenantrenos/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Modelos Animais de Doenças
Compostos de Epóxi/farmacologia
Inativação Gênica
Seres Humanos
Receptores de Hialuronatos/genética
Hialuronan Sintases/genética
Hialuronan Sintases/metabolismo
Neoplasias Pulmonares/tratamento farmacológico
Neoplasias Pulmonares/genética
Neoplasias Pulmonares/patologia
Masculino
RNA Interferente Pequeno/genética
Ratos
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Alkylating); 0 (CD44 protein, human); 0 (Diterpenes); 0 (Epoxy Compounds); 0 (Extracellular Matrix Proteins); 0 (Hyaluronan Receptors); 0 (Phenanthrenes); 0 (RNA, Small Interfering); 0 (hyaluronan-mediated motility receptor); 19ALD1S53J (triptolide); EC 2.4.1.212 (Hyaluronan Synthases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.18632/oncotarget.15879


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[PMID]:29478645
[Au] Autor:Rogula-Kozlowska W; Kozielska B; Majewski G; Rogula-Kopiec P; Mucha W; Kociszewska K
[Ad] Endereço:Institute of Environmental Engineering, Polish Academy of Sciences, 34 M. Sklodowska-Curie St., 41-819 Zabrze, Poland; The Main School of Fire Service, Faculty of Fire Safety Engineering, 52/54 Slowackiego St., 01-629 Warsaw, Poland. Electronic address: wioletta.rogula-kozlowska@ipis.zabrze.pl.
[Ti] Título:Submicron particle-bound polycyclic aromatic hydrocarbons in the Polish teaching rooms: Concentrations, origin and health hazard.
[So] Source:J Environ Sci (China);64:235-244, 2018 Feb.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The goal of the work was to investigate the concentrations of the 16 US EPA priority polycyclic aromatic hydrocarbons (PAH) bound to submicrometer particles (particulate matter, PM ) suspended in the air of university teaching rooms and in the atmospheric air outside. Two teaching rooms were selected in two Polish cities, Gliwice, southern Poland, and Warsaw, central Poland, differing with regard to the ambient concentrations and major sources of PM and PAH. The variabilities of indoor and outdoor 24-hr concentrations of PM -bound PAH, the ratio (I/O) of the indoor to outdoor 24-hr concentrations of PM -bound PAH, probable sources of PAH and the level of the hazard from the mixture of the 16 PAH (ΣPAH) to humans at both sites were analyzed. In both Warsaw and Gliwice, the mean concentrations of PM -bound ΣPAH were slightly higher in the atmospheric air than in the rooms. The indoor and outdoor concentrations of individual PAH in Gliwice were correlated, in Warsaw - they were not. Most probably, the lack of the correlations in Warsaw was due to the existence of an unidentified indoor source of gaseous PAH enriching PM in phenanthrene, fluorene, and pyrene. Although the ambient concentrations of PM -bound PAH were low compared to the ones observed earlier at both sites, they were much higher than in other urbanized European areas. However, because of low mass share of heavy PAH in ΣPAH, the various indicators of the health hazard from the 16 PAH mixture were low compared to other regions.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Poluição do Ar em Ambientes Fechados/análise
Exposição Ambiental/estatística & dados numéricos
Hidrocarbonetos Aromáticos Policíclicos/análise
Instituições Acadêmicas/estatística & dados numéricos
[Mh] Termos MeSH secundário: Poluição do Ar em Ambientes Fechados/estatística & dados numéricos
Fluorenos/análise
Seres Humanos
Material Particulado/análise
Fenantrenos/análise
Polônia
Pirenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Fluorenes); 0 (Particulate Matter); 0 (Phenanthrenes); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Pyrenes); 3Q2UY0968A (fluorene); 448J8E5BST (phenanthrene); 9E0T7WFW93 (pyrene)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE


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[PMID]:28587572
[Au] Autor:Maffo T; Melong R; Nganteng DND; Wafo P; Ali MS; Ngadjui BT
[Ad] Endereço:a Faculty of Science, Department of Organic Chemistry , University of Yaounde I , Yaoundé , Cameroon.
[Ti] Título:Neomacrodione: a new degraded diterpenoid from the roots of Neoboutonia macrocalyx Beng (Euphorbiaceae).
[So] Source:Nat Prod Res;32(1):85-90, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One new degraded diterpenoid 3,6-dihydroxy-1,7-dimethyl-9,10-phenantroquinone (neomacrodione) (1) together seven known compounds were isolated from the roots of Neoboutonia macrocalyx (Euphorbiaceae). The structures of the compounds were established based on their NMR and mass spectrometric data in conjunction with those previously reported in the literature. Compound (1) displayed moderate antibacterial activities.
[Mh] Termos MeSH primário: Antibacterianos/química
Diterpenos/química
Euphorbiaceae/química
Fenantrenos/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Diterpenos/farmacologia
Avaliação Pré-Clínica de Medicamentos/métodos
Espectroscopia de Ressonância Magnética
Testes de Sensibilidade Microbiana
Estrutura Molecular
Fenantrenos/farmacologia
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Diterpenes); 0 (Phenanthrenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1335729


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[PMID]:28465354
[Au] Autor:Farabegoli F; Govoni M; Spisni E; Papi A
[Ad] Endereço:Department of Pharmacology and Biotechnology (FaBiT), University of Bologna, Bologna, Italy fulvia.farabegoli@unibo.it.
[Ti] Título:EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion.
[So] Source:Biosci Rep;37(3), 2017 Jun 30.
[Is] ISSN:1573-4935
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Epidermal growth factor receptor (EGFR) expression is an important marker in breast carcinoma pathology and is considered a pivotal molecule for cancer cell proliferation, invasion and metastasis. We investigated the effects of epigallocatechin-3-gallate (EGCG), the most active green tea catechin, in combination with 6-OH-11-O-hydroxyphenanthrene (IIF), a synthetic retinoid X receptor-γ (RXRγ) agonist, on three breast carcinoma cell lines: MCF-7, MCF-7TAM and MDA-MB-231. EGFR and AKT activation and molecular markers of cell motility and migration (CD44, extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), MMP-2, MMP-9 and tissue inhibitor of metalloproteinases (TIMPs)) were studied after EGCG and IIF treatments. The EGCG + IIF treatment was the most active in down-regulating EGFR phosphorylation at Tyr in all the investigated cell lines; p473AKT was also down-regulated in MCF-TAM cells. EGCG + IIF was also the most active treatment in reducing the expression of markers of invasion and migration in all the three cell lines: CD44, EMMPRIN, MMP-2 and -9 expression decreased, whereas TIMPs were up-regulated. Zymography and scratch assay also confirmed the reduced invasion tendency. We considered that EGCG and IIF treatments could alter the molecular network based on EGFR, CD44 and EMMPRIN expression interdependence and reduced the migration tendency in MCF-7, MCF-7TAM and MDA-MB-231 cells. These events only occurred in association with AKT inactivation in MCF-7TAM cells. In conclusion, the combination of EGCG and IIF significantly attenuated the invasive behaviour of breast carcinoma cells.
[Mh] Termos MeSH primário: Neoplasias da Mama/tratamento farmacológico
Catequina/análogos & derivados
Movimento Celular/efeitos dos fármacos
Invasividade Neoplásica/patologia
Fenantrenos/farmacologia
Receptor do Fator de Crescimento Epidérmico/antagonistas & inibidores
[Mh] Termos MeSH secundário: Basigina/metabolismo
Neoplasias da Mama/metabolismo
Neoplasias da Mama/patologia
Catequina/farmacologia
Linhagem Celular Tumoral
Regulação para Baixo/efeitos dos fármacos
Feminino
Seres Humanos
Células MCF-7
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
Fosforilação/efeitos dos fármacos
Inibidores de Proteínas Quinases/farmacologia
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/efeitos dos fármacos
Inibidor Tecidual de Metaloproteinase-1/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (6-OH-11-O-hydroxyphenanthrene); 0 (Phenanthrenes); 0 (Protein Kinase Inhibitors); 0 (Tissue Inhibitor of Metalloproteinase-1); 136894-56-9 (Basigin); 8R1V1STN48 (Catechin); BQM438CTEL (epigallocatechin gallate); EC 2.7.10.1 (EGFR protein, human); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:28934708
[Au] Autor:Wang W; Wang J
[Ad] Endereço:Key Laboratory of Aquatic Botany and Watershed Ecology, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Different partition of polycyclic aromatic hydrocarbon on environmental particulates in freshwater: Microplastics in comparison to natural sediment.
[So] Source:Ecotoxicol Environ Saf;147:648-655, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Microplastics pollution in the aquatic ecosystems has aroused increasing concerns in recent years. Though microplastics are known to sorb organic contaminants from water, the interaction mechanisms between microplastics and organic chemicals are not yet well understood. Here we investigated the partition characteristics of phenanthrene (Phe) in three mass-produced plastic particles, including polyethylene (PE), polystyrene (PS) and polyvinylchloride (PVC), and one natural sediment, as a comparison. The sorption kinetics of Phe onto microplastics and natural sediment were successfully described by the pseudo-second-order model (R > 0.992), while the equilibrium data were best-fitted to the Langmuir isotherm (R > 0.995). Compared with natural sediment, microplastics exhibited higher capacities for Phe which followed an order of PE > PS > PVC. As the aqueous concentration of pyrene (Pyr) increased, both uptakes and distribution coefficients (K ) of Phe within the solids decreased, with natural sediment giving the largest decline. Although proportions of Phe desorbed from the contaminated microplastics were low, due to the high Phe uptake, microplastics released larger amounts of the sorbed Phe to water than the natural sediment during the desorption process. Given their minimal abundance relative to natural sediment, microplastics may play a less important role in the transport of organic pollutants in a natural aquatic environment.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Água Doce/química
Sedimentos Geológicos/química
Plásticos/química
Hidrocarbonetos Aromáticos Policíclicos/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Adsorção
Fenantrenos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenanthrenes); 0 (Plastics); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Water Pollutants, Chemical); 448J8E5BST (phenanthrene)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE


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[PMID]:28923724
[Au] Autor:Anyanwu IN; Ikpikpini OC; Semple KT
[Ad] Endereço:Lancaster Environment Centre, Lancaster University, Lancaster, United Kingdom; Department of Biological Sciences, Federal University Ndufu-Alike Ikwo, P.M.B 1010 Abakaliki, Ebonyi State, Nigeria. Electronic address: ihuomal@yahoo.com.
[Ti] Título:Impact of nitrogen-polycyclic aromatic hydrocarbons on phenanthrene and benzo[a]pyrene mineralisation in soil.
[So] Source:Ecotoxicol Environ Saf;147:594-601, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:When aromatic hydrocarbons are present in contaminated soils, they often occur in mixtures. The impact of four different (3-ring) nitrogen-containing polycyclic aromatic hydrocarbons (N-PAHs) on C-phenanthrene and C-benzo[a]pyrene (B[a]P) mineralisation in soil was investigated over a 90 d incubation period. The results revealed that both C-phenanthrene and C-benzo[a]pyrene showed no significant mineralisation in soils amended with 10mgkg and 100mgkg N-PAHs (p>0.05). However, increases in lag-phases and decreases in the rates and extents of mineralisation were observed, over time. Among the N-PAHs, benzo[h]quinoline impacted C-phenanthrene mineralisation with extended and diauxic lag phases. Furthermore, C-B[a]P and C-benzo[a]pyrene-nitrogen-containing polycyclic aromatic hydrocarbons ( C-B[a]P-N-PAHs) amended soils showed extensive lag phases (> 21 d); with some C-B[a]P-N-PAH mineralisation recording <1% in both concentrations (10mgkg and 100mgkg ), over time. This study suggests that the presence of N-PAHs in contaminated soil may impact the microbial degradation of polycyclic aromatic hydrocarbons (PAHs) and the impact was most likely the result of limited success in achieving absolute biodegradation of some PAHs in soil.
[Mh] Termos MeSH primário: Benzo(a)pireno/análise
Nitrogênio/análise
Fenantrenos/análise
Hidrocarbonetos Aromáticos Policíclicos/análise
Microbiologia do Solo
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Benzo(a)pireno/metabolismo
Biodegradação Ambiental
Monitoramento Ambiental
Fenantrenos/metabolismo
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenanthrenes); 0 (Polycyclic Aromatic Hydrocarbons); 0 (Soil); 0 (Soil Pollutants); 3417WMA06D (Benzo(a)pyrene); 448J8E5BST (phenanthrene); N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170920
[St] Status:MEDLINE


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[PMID]:29195901
[Au] Autor:Chen H; Chen Q; Jiang CM; Shi GY; Sui BW; Zhang W; Yang LZ; Li ZY; Liu L; Su YM; Zhao WC; Sun HQ; Li ZZ; Fu Z
[Ad] Endereço:Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China; China International Science and Technology Cooperation base of Child development and Critical Disorders, China; Chongqing Engineeri
[Ti] Título:Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition.
[So] Source:Toxicol Lett;284:1-9, 2018 Mar 01.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Idiopathic pulmonary fibrosis (IPF) and tumor are highly similar to abnormal cell proliferation that damages the body. This malignant cell evolution in a stressful environment closely resembles that of epithelial-mesenchymal transition (EMT). As a popular EMT-inducing factor, TGFß plays an important role in the progression of multiple diseases. However, the drugs that target TGFB1 are limited. In this study, we found that triptolide (TPL), a Chinese medicine extract, exerts an anti-lung fibrosis effect by inhibiting the EMT of lung epithelial cells. In addition, triptolide directly binds to TGFß and subsequently increase E-cadherin expression and decrease vimentin expression. In in vivo studies, TPL improves the survival state and inhibits lung fibrosis in mice. In summary, this study revealed the potential therapeutic effect of paraquat induced TPL in lung fibrosis by regulating TGFß-dependent EMT progression.
[Mh] Termos MeSH primário: Diterpenos/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Transição Epitelial-Mesenquimal/efeitos dos fármacos
Fibrose Pulmonar Idiopática/prevenção & controle
Paraquat/toxicidade
Fenantrenos/uso terapêutico
Fator de Crescimento Transformador beta1/metabolismo
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Movimento Celular/efeitos dos fármacos
Modelos Animais de Doenças
Diterpenos/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/metabolismo
Células Epiteliais/patologia
Compostos de Epóxi/farmacologia
Compostos de Epóxi/uso terapêutico
Seres Humanos
Fibrose Pulmonar Idiopática/induzido quimicamente
Fibrose Pulmonar Idiopática/metabolismo
Fibrose Pulmonar Idiopática/patologia
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Pulmão/patologia
Camundongos
Simulação de Acoplamento Molecular
Fenantrenos/farmacologia
Ligação Proteica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Drugs, Chinese Herbal); 0 (Epoxy Compounds); 0 (Phenanthrenes); 0 (Tgfb1 protein, mouse); 0 (Transforming Growth Factor beta1); 19ALD1S53J (triptolide); PLG39H7695 (Paraquat)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


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[PMID]:29406113
[Au] Autor:Ni N; Shi R; Liu Z; Bian Y; Wang F; Song Y; Jiang X
[Ad] Endereço:Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address: nni@issas.ac.cn.
[Ti] Título:Effects of biochars on the bioaccessibility of phenanthrene/pyrene/zinc/lead and microbial community structure in a soil under aerobic and anaerobic conditions.
[So] Source:J Environ Sci (China);63:296-306, 2018 Jan.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The immobilization of co-contaminants of organic and inorganic pollutants by biochar is an efficient remediation strategy. However, the effect of biochar amendments on the bioaccessibility of the co-contaminants in dry versus flooded soils has rarely been compared. In batch experiments, bamboo-derived biochar (BB) had a higher sorption capacity for phenanthrene (Phe)/pyrene (Pyr)/zinc (Zn) than corn straw-derived biochar (CB), while CB had a higher sorption capacity for lead (Pb) than BB. After 150days of incubation, the amendments of 2% CB, 0.5% BB and 2% BB effectively suppressed the dissipation and reduced the bioaccessibility of Phe/Pyr by 15.65%/18.02%, 17.07%/18.31% and 25.43%/27.11%, respectively, in the aerobic soils. This effectiveness was more significant than that in the anaerobic soils. The accessible Zn/Pb concentrations were also significantly lower in the aerobic soils than in the anaerobic soils, regardless of treatments. The Gram-negative bacterial biomass and the Shannon-Weaver index in the aerobic soil amended with 2% CB were the highest. The soil microbial community structure was jointly affected by changes in the bioaccessibility of the co-contaminants and the soil physiochemical properties caused by biochar amendments under the two conditions. Therefore, dry land farming may be more reliable than paddy soil cultivation at reducing the bioaccessibility of Phe/Pyr/Zn/Pb and enhancing the soil microbial diversity in the short term.
[Mh] Termos MeSH primário: Microbiologia do Solo
Poluentes do Solo/análise
[Mh] Termos MeSH secundário: Carvão Vegetal
Chumbo/análise
Chumbo/toxicidade
Fenantrenos/análise
Fenantrenos/toxicidade
Pirenos
Solo/química
Poluentes do Solo/toxicidade
Zinco/análise
Zinco/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenanthrenes); 0 (Pyrenes); 0 (Soil); 0 (Soil Pollutants); 0 (biochar); 16291-96-6 (Charcoal); 2P299V784P (Lead); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE



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