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[PMID]:28954370
[Au] Autor:Qiao L; Zheng XB; Yan X; Wang MH; Zheng J; Chen SJ; Yang ZY; Mai BX
[Ad] Endereço:State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
[Ti] Título:Brominated flame retardant (BFRs) and Dechlorane Plus (DP) in paired human serum and segmented hair.
[So] Source:Ecotoxicol Environ Saf;147:803-808, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Brominated flame retardants (BFRs) and Dechlorane Plus (DP) were measured in both human hair and paired serum samples from a cohort of university students in South China. Segmental analysis was conducted to explore gender difference and the relationships between the hair and serum. The concentrations of total PBDEs in the hair and serum samples were in a range of 0.28-34.1ng/g dry weight (dw) and 0.16-156ng/g lipid weight (lw), respectively. Concentrations of ∑DPs (sum of the syn-DP and anti-DP isomers) in all hair samples ranged from nd-5.45ng/g dry weight. Concentrations of most PBDEs and decabromodiphenylethane (DBDPE) in distal segments (5-10cm from the scalp) were higher than those in the proximal segments (0-5cm from the scalp) (t-test, p < 0.05), which could be due to the longer exposure time of distal segments. The proximal segments exhibited a unique congener profile, more close to that in the serum rather than the distal segments of hair. An obvious gender difference was found in the levels of ∑PBDEs using integrated hair samples, while the difference disappeared when considering alone the proximal segments of hair (0-5cm from scalp) for both genders. This paper provides supplement to the current knowledge on sources of BFRs and DPs in hair and declares the importance of segmental analysis.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Retardadores de Chama/análise
Cabelo/química
Éteres Difenil Halogenados/sangue
Hidrocarbonetos Bromados/sangue
Hidrocarbonetos Clorados/sangue
Compostos Policíclicos/sangue
[Mh] Termos MeSH secundário: China
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Éteres Difenil Halogenados/análise
Seres Humanos
Hidrocarbonetos Bromados/análise
Hidrocarbonetos Clorados/análise
Masculino
Compostos Policíclicos/análise
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Brominated); 0 (Hydrocarbons, Chlorinated); 0 (Polycyclic Compounds); 0 (dechlorane plus)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE


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[PMID]:29188248
[Au] Autor:Saini KM; Saunthwal RK; Verma AK
[Ad] Endereço:Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India. averma@acbr.du.ac.in.
[Ti] Título:Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene.
[So] Source:Org Biomol Chem;15(48):10289-10298, 2017 Dec 13.
[Is] ISSN:1477-0539
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Unsymmetrical one-pot sequential cross-coupling reactions of sterically hindered tetrabromothiophene with arylboronic acid and an alkyne/alkene to afford selective bi-, tri-, and tetrasubstituted aryl/alkynyl-thiophenes with the aid of a palladium catalyst were described. The reaction proceeds via a site-selective Suzuki/Sonogashira coupling, followed by selective Sonogashira, Suzuki and Heck coupling reactions. This methodology has demonstrated an important framework for the synthesis of organic scaffolds.
[Mh] Termos MeSH primário: Hidrocarbonetos Bromados/síntese química
Chumbo/química
Tiofenos/síntese química
[Mh] Termos MeSH secundário: Catálise
Hidrocarbonetos Bromados/química
Estrutura Molecular
Tiofenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Brominated); 0 (Thiophenes); 2P299V784P (Lead)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1039/c7ob02601c


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[PMID]:28951040
[Au] Autor:Shi Y; Xu X; Chen J; Liang R; Zheng X; Shi Y; Wang Y
[Ad] Endereço:State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
[Ti] Título:Antioxidant gene expression and metabolic responses of earthworms (Eisenia fetida) after exposure to various concentrations of hexabromocyclododecane.
[So] Source:Environ Pollut;232:245-251, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hexabromocyclododecane (HBCD), a ubiquitous suspected contaminant, is one of the world's most prominent brominated flame retardants (BFRs). In the present study, earthworms (Eisenia fetida) were exposed to HBCD. The expression of selected antioxidant enzyme genes was measured, and the metabolic responses were assessed using nuclear magnetic resonance (NMR) to identify the molecular mechanism of the antioxidant stress reaction and the metabolic reactions of earthworms to HBCD. A significant up-regulation (p < 0.05) of superoxide dismutase (SOD) gene expression was detected, with the highest gene expression level of SOD appearing at a dose of 400 mg kg dw (2.06-fold, p < 0.01). However, the glutathione transferase (GST) gene expression levels did not differ significantly (p > 0.05). Principal component analysis (PCA) of the metabolic responses showed that all groups could be clearly differentiated, and the highest concentration dose group was the most distant from the control group. Except for fumarate, the measured metabolites, which included adenosine triphosphate (ATP), valine, lysine, glycine, betaine and lactate, revealed significant (p < 0.05) increases after 14 days of exposure to HBCD. HBCD likely induces high levels of anaerobic respiration, which would result in high levels of ATP and lead to the disintegration of proteins into amino acids, including valine and lysine, to produce energy. The observed changes in osmotic pressure were indicative of damage to the membrane structure. Furthermore, this study showed that NMR-based metabolomics was a more sensitive tool than measuring the gene expression levels for elucidating the mode of toxicity of HBCD in earthworm exposure studies.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Expressão Gênica/efeitos dos fármacos
Hidrocarbonetos Bromados/toxicidade
Oligoquetos/fisiologia
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Animais
Retardadores de Chama/metabolismo
Glutationa Transferase/genética
Glutationa Transferase/metabolismo
Espectroscopia de Ressonância Magnética
Metabolômica
Oligoquetos/metabolismo
Análise de Componente Principal
Superóxido Dismutase/genética
Superóxido Dismutase/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flame Retardants); 0 (Hydrocarbons, Brominated); 0 (Soil Pollutants); 5I9835JO3M (hexabromocyclododecane); EC 1.15.1.1 (Superoxide Dismutase); EC 2.5.1.18 (Glutathione Transferase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE


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[PMID]:29191319
[Au] Autor:Miyake Y; Tokumura M; Wang Q; Amagai T; Horii Y
[Ad] Endereço:University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address: y-miyake@u-shizuoka-ken.ac.jp.
[Ti] Título:Rate of hexabromocyclododecane decomposition and production of brominated polycyclic aromatic hydrocarbons during combustion in a pilot-scale incinerator.
[So] Source:J Environ Sci (China);61:91-96, 2017 Nov.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Here, we examined the incineration of extruded polystyrene containing hexabromocyclododecane (HBCD) in a pilot-scale incinerator under various combustion temperatures (800-950°C) and flue gas residence times (2-8sec). Rates of HBCD decomposition ranged from 99.996% (800°C, 2sec) to 99.9999% (950°C, 8sec); the decomposition of HBCD, except during the initial stage of combustion (flue gas residence time<2sec), followed a pseudo-first-order kinetics model. An Arrhenius plot revealed that the activation energy and frequency factor of the decomposition of HBCD by combustion were 14.2kJ/mol and 1.69sec , respectively. During combustion, 11 brominated polycyclic aromatic hydrocarbons (BrPAHs) were detected as unintentional by-products. Of the 11 BrPAHs detected, 2-bromoanthracene and 1-bromopyrene were detected at the highest concentrations. The mutagenic and carcinogenic BrPAHs 1,5-dibromoanthracene and 1-bromopyrene were most frequently detected in the flue gases analyzed. The total concentration of BrPAHs exponentially increased (range, 87.8-2,040,000ng/m ) with increasing flue gas residence time. Results from a qualitative analysis using gas chromatography/high-resolution mass spectrometry suggest that bromofluorene and bromopyrene (or fluoranthene) congeners were also produced during the combustion.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Hidrocarbonetos Bromados/análise
Incineração/métodos
Hidrocarbonetos Aromáticos Policíclicos/análise
[Mh] Termos MeSH secundário: Poluentes Atmosféricos/química
Hidrocarbonetos Bromados/química
Modelos Químicos
Hidrocarbonetos Aromáticos Policíclicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Hydrocarbons, Brominated); 0 (Polycyclic Aromatic Hydrocarbons); 5I9835JO3M (hexabromocyclododecane)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28854125
[Au] Autor:Berntsen HF; Berg V; Thomsen C; Ropstad E; Zimmer KE
[Ad] Endereço:a Department of Production Animal Clinical Sciences, Section of Experimental Biomedicine , NMBU-School of Veterinary Science , Oslo , Norway.
[Ti] Título:The design of an environmentally relevant mixture of persistent organic pollutants for use in in vivo and in vitro studies.
[So] Source:J Toxicol Environ Health A;80(16-18):1002-1016, 2017.
[Is] ISSN:1528-7394
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Amongst the substances listed as persistent organic pollutants (POP) under the Stockholm Convention on Persistent Organic Pollutants (SCPOP) are chlorinated, brominated, and fluorinated compounds. Most experimental studies investigating effects of POP employ single compounds. Studies focusing on effects of POP mixtures are limited, and often conducted using extracts from collected specimens. Confounding effects of unmeasured substances in such extracts may bias the estimates of presumed causal relationships being examined. The aim of this investigation was to design a model of an environmentally relevant mixture of POP for use in experimental studies, containing 29 different chlorinated, brominated, and perfluorinated compounds. POP listed under the SCPOP and reported to occur at the highest levels in Scandinavian food, blood, or breast milk prior to 2012 were selected, and two different mixtures representing varying exposure scenarios constructed. The in vivo mixture contained POP concentrations based upon human estimated daily intakes (EDIs), whereas the in vitro mixture was based upon levels in human blood. In addition to total in vitro mixture, 6 submixtures containing the same concentration of chlorinated + brominated, chlorinated + perfluorinated, brominated + perfluorinated, or chlorinated, brominated or perfluorinated compounds only were constructed. Using submixtures enables investigating the effect of adding or removing one or more chemical groups. Concentrations of compounds included in feed and in vitro mixtures were verified by chemical analysis. It is suggested that this method may be utilized to construct realistic mixtures of environmental contaminants for toxicity studies based upon the relative levels of POP to which individuals are exposed.
[Mh] Termos MeSH primário: Poluentes Ambientais/toxicidade
Compostos Orgânicos/toxicidade
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Poluentes Ambientais/sangue
Poluição Ambiental/efeitos adversos
Fluorcarbonetos/sangue
Fluorcarbonetos/toxicidade
Análise de Alimentos
Contaminação de Alimentos/análise
Seres Humanos
Hidrocarbonetos Bromados/sangue
Hidrocarbonetos Bromados/toxicidade
Hidrocarbonetos Clorados/sangue
Hidrocarbonetos Clorados/toxicidade
Compostos Orgânicos/sangue
Bifenilos Policlorados/sangue
Bifenilos Policlorados/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Fluorocarbons); 0 (Hydrocarbons, Brominated); 0 (Hydrocarbons, Chlorinated); 0 (Organic Chemicals); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1080/15287394.2017.1354439


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[PMID]:28752240
[Au] Autor:Daso AP; Rohwer ER; Koot DJ; Okonkwo JO
[Ad] Endereço:Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Private Bag X20, Hatfield, Pretoria, 0028, South Africa. adegbenrop@gmail.com.
[Ti] Título:Preliminary screening of polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCDD) and tetrabromobisphenol A (TBBPA) flame retardants in landfill leachate.
[So] Source:Environ Monit Assess;189(8):418, 2017 Aug.
[Is] ISSN:1573-2959
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The occurrence of selected brominated flame retardants, including nine polybrominated diphenyl ether (PBDE) congeners, hexabromocyclododecane (HBCDD) and tetrabromobisphenol A (TBBPA) in leachate samples from eight landfill sites in South Africa, were investigated. In addition, the possible influences of dissolved organic carbon on their levels were also evaluated. Filtered leachate samples were subjected to solid-phase extraction to isolate the various target compounds. PBDEs with six bromine substituents and above, as well as α-HBCDD, ß-HBCDD and TBBPA, were generally found below the detection limit. However, the mean value of the total lower PBDE congeners ranged between 0.04 and 0.48 µg L , and the concentrations of γ-HBCDD ranged from not detectable (ND) to 0.05 µg L . No significant correlation was observed between the target compounds and dissolved organic carbon, although weak to moderate correlations were mostly observed for the lower PBDEs.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Retardadores de Chama/análise
Éteres Difenil Halogenados/análise
Hidrocarbonetos Bromados/análise
[Mh] Termos MeSH secundário: Bifenil Polibromatos
Extração em Fase Sólida
África do Sul
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Brominated); 0 (Polybrominated Biphenyls); 0 (Water Pollutants, Chemical); 5I9835JO3M (hexabromocyclododecane); FQI02RFC3A (tetrabromobisphenol A)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1007/s10661-017-6131-z


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[PMID]:28734216
[Au] Autor:Rani M; Shim WJ; Jang M; Han GM; Hong SH
[Ad] Endereço:Oil and POPs Research Group, Korea Institute of Ocean Science and Technology, Geoje-shi 656-834, South Korea.
[Ti] Título:Releasing of hexabromocyclododecanes from expanded polystyrenes in seawater -field and laboratory experiments.
[So] Source:Chemosphere;185:798-805, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Expanded polystyrene (EPS) is a major component of marine debris globally. Recently, hazardous hexabromocyclododecanes (HBCDDs) were detected in EPS buoys used for aquaculture farming. Subsequently, enrichment of HBCDDs was found in nearby marine sediments and mussels growing on EPS buoys. It was suspected that EPS buoys and their debris might be sources of HBCDDs. To confirm this, the release of HBCDDs from EPS spherules detached from a buoy to seawater was investigated under field (open sea surface and closed outdoor chambers with sun exposure and in the dark) and laboratory (particle-size) conditions. In all exposure groups, initial rapid leaching of HBCDDs was followed by slow desorption over time. Abundant release of HBCDDs was observed from EPS spherules exposed to the open sea surface (natural) and on exposure to sunlight irradiation or in the dark in controlled saline water. Water leaching and UV-light/temperature along with possibly biodegradation were responsible for about 37% and 12% of HBCDDs flux, respectively. Crumbled EPS particles (≤1 mm) in samples deployed on the sea surface for 6 months showed a high degree of weathering. This implies that surface erosion and further fragmentation of EPS via environmental weathering could enhance the leaching of HBCDDs from the surface of EPS. Overall, in the marine environment, HBCDDs could be released to a great extent from EPS products and their debris due to the cumulative effects of the movement of large volumes of water (dilution), biodegradation, UV-light/temperature, wave action (shaking), salinity and further fragmentation of EPS spherules.
[Mh] Termos MeSH primário: Monitoramento Ambiental
Hidrocarbonetos Bromados/química
Poliestirenos/química
Resíduos/análise
[Mh] Termos MeSH secundário: Aquicultura
Modelos Químicos
Oceanos e Mares
Tamanho da Partícula
Poliestirenos/análise
Água do Mar/química
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Brominated); 0 (Polystyrenes); 0 (Waste Products); 0 (Water Pollutants, Chemical); 5I9835JO3M (hexabromocyclododecane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170723
[St] Status:MEDLINE


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[PMID]:28641560
[Au] Autor:Georgakis N; Chronopoulou E; Gad MA; Skliros D; Efrose R; Flemetakis E; Labrou NE
[Ad] Endereço:Laboratory of Enzyme Technology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, 75 Iera Odos Street, GR-11855-Athens. Greece.
[Ti] Título:Functional and Catalytic Characterization of the Detoxifying Enzyme Haloalkane Dehalogenase from Rhizobium leguminosarum.
[So] Source:Protein Pept Lett;24(7):599-608, 2017.
[Is] ISSN:1875-5305
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Haloalkane dehalogenases (EC 3.8.1.5, HLDs) are α/ß-hydrolases which catalyze the irreversible cleavage of carbon-halogen bonds of haloalkanes, producing an alcohol, a halide and a hydrogen ion. Haloalkanes are acutely toxic to animals and humans and their toxic effects are mainly observed in the liver, kidneys and central nervous system. OBJECTIVE: In the present work, the haloalkane dehalogenase from Rhizobium leguminosarum bv. trifolii (DrlA) was characterized. METHOD: Reverse transcription polymerase chain reaction analysis and enzyme activity assays revealed that the DrlA gene expression in R. leguminosarum bv. trifolii is induced by 1,2- dibromoethane (1,2-DBE) during the early exponential phase. The gene of the enzyme was isolated, cloned and expressed in E. coli Rosetta (DE3). RESULTS: Recombinant DrlA displays its high catalytic activity towards 1,2-DBE and the long-chain haloalkane 1-iodohexane. Limited activity was observed for other aliphatic and cyclic haloalkanes, indicating that the enzyme displays restricted substrate specificity, compared to other bacterial HLDs. Homology modelling and phylogenetic analysis suggested that the enzyme belongs to the HLD-II subfamily and shares the same overall fold and domain organization as other bacterial HLDs, however major variations were identified at the hydrophobic substrate-binding cavity, the cap domain and the entrance of the main tunnel that affect the size of the active site pocket and the substrate recognition mechanism. CONCLUSION: This work sheds new light on the environmental fate and toxicity of 1,2-DBE and provides new knowledge on the structure, function and diversity of HLDs for developing applications in toxicology.
[Mh] Termos MeSH primário: Catálise
Hidrolases/metabolismo
Rhizobium leguminosarum/enzimologia
[Mh] Termos MeSH secundário: Sítios de Ligação
Domínio Catalítico
Cristalografia por Raios X
Recuperação e Remediação Ambiental
Escherichia coli/genética
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Hidrocarbonetos Bromados/química
Hidrocarbonetos Bromados/toxicidade
Hidrolases/química
Hidrolases/genética
Modelos Moleculares
Filogenia
Dobramento de Proteína
Rhizobium leguminosarum/química
Especificidade por Substrato
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Brominated); EC 3.- (Hydrolases); EC 3.8.1.5 (haloalkane dehalogenase); LI8384T9PH (bromoethane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170624
[St] Status:MEDLINE
[do] DOI:10.2174/0929866524666170621094531


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[PMID]:28622357
[Au] Autor:Xue M; Liu Y; Lyu R; Ge N; Liu M; Ma Y; Liang H
[Ad] Endereço:Qingdao University of Medicine, Qingdao, PR China.
[Ti] Título:Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats.
[So] Source:PLoS One;12(6):e0178684, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study investigated the protective effect of aplysin on the liver and its influence on inflammation and the gut microbiota in rats with ethanol-induced liver injury. METHODS: Male Sprague-Dawley rats were randomly assigned to an alcohol-containing liquid diet, control liquid diet or treatment with aplysin for 8 weeks. Hepatic and intestinal histopathological analysis was performed, and cytokine levels and the intestinal mucosal barrier were assessed. Enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) and 16S rDNA high-throughput sequencing were performed to provide an overview of the gut microbiota composition. RESULTS: Chronic alcohol exposure caused liver damage in rats. Serum aspartate aminotransferase (AST), aminotransferase (ALT), alkaline phosphatase (ALP) and triglyceride (TG) activities in liver tissue were higher than in the control group. Alcohol administration elevated the levels of serum transforming growth factor-ß (TGF-ß) and tumor necrosis factor-α (TNF-α) and reduced interleukin-10 (IL-10) levels compared with those of control rats. In addition, the levels of plasma endotoxin, diamine oxidase (DAO), and fatty acid-binding protein 2 (FABP2) in the alcohol group were higher than in the control group. The results of ERIC-PCR indicated that aplysin treatment shifted the overall structure of the ethanol-disrupted gut microbiota toward that of the control group. One hundred twenty to 190 genera of bacteria were detected by high throughput sequencing. Alcohol-induced changes in the gut microbial composition were detected at the genus level. These alcohol-induced effects could be reversed with aplysin treatment. CONCLUSIONS: These results suggest that aplysin exerts a protective effect on ethanol-induced hepatic injury in rats by normalizing fecal microbiota composition and repairing intestinal barrier function.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas
Enterobacteriaceae/metabolismo
Etanol/efeitos adversos
Microbioma Gastrointestinal/efeitos dos fármacos
Hidrocarbonetos Bromados/farmacologia
Fígado/metabolismo
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/microbiologia
Citocinas/sangue
DNA Bacteriano/genética
DNA Ribossômico/genética
Enterobacteriaceae/genética
Etanol/farmacologia
Microbioma Gastrointestinal/genética
Fígado/patologia
Masculino
RNA Ribossômico 16S/genética
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Hydrocarbons, Brominated); 0 (RNA, Ribosomal, 16S); 0 (Sesquiterpenes); 0 (aplysin); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178684


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[PMID]:28618277
[Au] Autor:Zhu H; Sun H; Yao Y; Wang F; Zhang Y; Liu X
[Ad] Endereço:MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China.
[Ti] Título:Fate and adverse effects of hexabromocyclododecane diastereoisomers (HBCDDs) in a soil-ryegrass pot system.
[So] Source:Chemosphere;184:452-459, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study explored the fate and adverse effects of 3 main hexabromocyclododecane diastereoisomers (α-, ß-, and γ-HBCDDs) in a soil pot system planted with ryegrass (Lolium perenne L.) using a short-term (8 weeks) experiment. At the end of the experiment, soil urease activity in planted spiked soil increased and catalase activity decreased; while there was no obvious change in sucrase and peroxidase activities. HBCDDs mainly accumulated in the root of ryegrass, with root concentration factors (RCF) in the range of 1.46-4.43 and only a small part was transferred to the stem (SCF: 0.198-0.305) and leaf (LCF: 0.042-0.062). The concentration factors varied for different HBCDD diastereoisomers, being in the order of α- > ß- > Î³-HBCDD for all tissues, indicating preferential accumulation of α-HBCDD in ryegrass tissues. Moreover, the enantiomeric analysis revealed an enrichment of (+)-α-, (-)-ß- and (+)-γ-HBCDD enantiomers in ryegrass tissues. ß- and γ-HBCDDs (up to 1.90% and 4.11%, respectively) were transformed to aα-HBCDD in ryegrass, while no isomerization product from α-HBCDD was found. Hydroxylated HBCDDs metabolites, such as monoOHHBCDDs and diOHHBCDDs were found in ryegrass tissues for the first time.
[Mh] Termos MeSH primário: Hidrocarbonetos Bromados/química
Lolium/metabolismo
[Mh] Termos MeSH secundário: Lolium/química
Folhas de Planta/metabolismo
Raízes de Plantas/metabolismo
Solo/química
Poluentes do Solo/análise
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Brominated); 0 (Soil); 0 (Soil Pollutants); 5I9835JO3M (hexabromocyclododecane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE



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