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[PMID]:28954370
[Au] Autor:Qiao L; Zheng XB; Yan X; Wang MH; Zheng J; Chen SJ; Yang ZY; Mai BX
[Ad] Endereço:State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
[Ti] Título:Brominated flame retardant (BFRs) and Dechlorane Plus (DP) in paired human serum and segmented hair.
[So] Source:Ecotoxicol Environ Saf;147:803-808, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Brominated flame retardants (BFRs) and Dechlorane Plus (DP) were measured in both human hair and paired serum samples from a cohort of university students in South China. Segmental analysis was conducted to explore gender difference and the relationships between the hair and serum. The concentrations of total PBDEs in the hair and serum samples were in a range of 0.28-34.1ng/g dry weight (dw) and 0.16-156ng/g lipid weight (lw), respectively. Concentrations of ∑DPs (sum of the syn-DP and anti-DP isomers) in all hair samples ranged from nd-5.45ng/g dry weight. Concentrations of most PBDEs and decabromodiphenylethane (DBDPE) in distal segments (5-10cm from the scalp) were higher than those in the proximal segments (0-5cm from the scalp) (t-test, p < 0.05), which could be due to the longer exposure time of distal segments. The proximal segments exhibited a unique congener profile, more close to that in the serum rather than the distal segments of hair. An obvious gender difference was found in the levels of ∑PBDEs using integrated hair samples, while the difference disappeared when considering alone the proximal segments of hair (0-5cm from scalp) for both genders. This paper provides supplement to the current knowledge on sources of BFRs and DPs in hair and declares the importance of segmental analysis.
[Mh] Termos MeSH primário: Monitoramento Ambiental/métodos
Retardadores de Chama/análise
Cabelo/química
Éteres Difenil Halogenados/sangue
Hidrocarbonetos Bromados/sangue
Hidrocarbonetos Clorados/sangue
Compostos Policíclicos/sangue
[Mh] Termos MeSH secundário: China
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Éteres Difenil Halogenados/análise
Seres Humanos
Hidrocarbonetos Bromados/análise
Hidrocarbonetos Clorados/análise
Masculino
Compostos Policíclicos/análise
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Brominated); 0 (Hydrocarbons, Chlorinated); 0 (Polycyclic Compounds); 0 (dechlorane plus)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE


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[PMID]:29253825
[Au] Autor:Schinkel L; Lehner S; Knobloch M; Lienemann P; Bogdal C; McNeill K; Heeb NV
[Ad] Endereço:Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Advanced Analytical Technologies, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland; ETH, Swiss Federal Institute of Technology, Institute of Biogeochemistry and Pollutant Dynamic, Universitätsstrasse 16, CH-8092 Z
[Ti] Título:Transformation of chlorinated paraffins to olefins during metal work and thermal exposure - Deconvolution of mass spectra and kinetics.
[So] Source:Chemosphere;194:803-811, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chlorinated paraffins (CPs) are high production volume chemicals widely used as additives in metal working fluids. Thereby, CPs are exposed to hot metal surfaces which may induce degradation processes. We hypothesized that the elimination of hydrochloric acid would transform CPs into chlorinated olefins (COs). Mass spectrometry is widely used to detect CPs, mostly in the selected ion monitoring mode (SIM) evaluating 2-3 ions at mass resolutions R < 20'000. This approach is not suited to detected COs, because their mass spectra strongly overlap with CPs. We applied a mathematical deconvolution method based on full-scan MS data to separate interfered CP/CO spectra. Metal drilling indeed induced HCl-losses. CO proportions in exposed mixtures of chlorotridecanes increased. Thermal exposure of chlorotridecanes at 160, 180, 200 and 220 °C also induced dehydrohalogenation reactions and CO proportions also increased. Deconvolution of respective mass spectra is needed to study the CP transformation kinetics without bias from CO interferences. Apparent first-order rate constants (k ) increased up to 0.17, 0.29 and 0.46 h for penta-, hexa- and heptachloro-tridecanes exposed at 220 °C. Respective half-life times (τ ) decreased from 4.0 to 2.4 and 1.5 h. Thus, higher chlorinated paraffins degrade faster than lower chlorinated ones. In conclusion, exposure of CPs during metal drilling and thermal treatment induced HCl losses and CO formation. It is expected that CPs and COs are co-released from such processes. Full-scan mass spectra and subsequent deconvolution of interfered signals is a promising approach to tackle the CP/CO problem, in case of insufficient mass resolution.
[Mh] Termos MeSH primário: Alcenos/síntese química
Hidrocarbonetos Clorados/química
Parafina/química
[Mh] Termos MeSH secundário: Monitoramento Ambiental/métodos
Temperatura Alta
Hidrocarbonetos Clorados/análise
Cinética
Espectrometria de Massas/métodos
Metalurgia
Parafina/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkenes); 0 (Hydrocarbons, Chlorinated); 8002-74-2 (Paraffin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29247930
[Au] Autor:Kopko O; Dabrowska H
[Ad] Endereço:National Marine Fisheries Research Institute (NMFRI), Gdynia, Poland.
[Ti] Título:Variability of biological indices, biomarkers, and organochlorine contaminants in flounder (Platichthys flesus) in the Gulf of Gdansk, southern Baltic Sea.
[So] Source:Chemosphere;194:701-713, 2018 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Biological indices, biomarkers (EROD activity, DNA SB, 1-OH pyrene), and organochlorine contaminants were investigated in flounder collected in the Gulf of Gdansk during March-December 2011 to describe their seasonal variability and interrelations. Univariate and multivariate statistics were used to evaluate the relations. The EROD activity positively correlated with DNA SB, both negatively correlated with CF, GSI, and HSI, and there was a moderate positive correlation for EROD and DNA SB with 1-OH pyrene. EROD highest activity corresponded to a resting stage of gonad development. DNA SB, highest during spawning, gradually decreased until late autumn. The PCBs, DDTs, HCB, HCHs, dieldrin, and heptachlor levels in muscle tissue were quantified on a wet and lipid basis. In each case, their levels decreased after spawning, fluctuated over the study period indicating that their accumulation was pronouncedly controlled by chemical-specific properties, their levels in prey, and lipid dynamics.
[Mh] Termos MeSH primário: Linguado/metabolismo
[Mh] Termos MeSH secundário: Animais
Países Bálticos
Biomarcadores/análise
Linguado/fisiologia
Hidrocarbonetos Clorados/química
Músculos/química
Bifenilos Policlorados/análise
Estações do Ano
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Hydrocarbons, Chlorinated); 0 (Water Pollutants, Chemical); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE


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[PMID]:29260544
[Au] Autor:Tiong SH; Saparin N; Teh HF; Ng TLM; Md Zain MZB; Neoh BK; Md Noor A; Tan CP; Lai OM; Appleton DR
[Ad] Endereço:Sime Darby Technology Centre Sdn. Bhd. , 1st Floor, Block B, UPM-MTDC Technology Centre III, Lebuh Silikon, 43400 Serdang, Selangor, Malaysia.
[Ti] Título:Natural Organochlorines as Precursors of 3-Monochloropropanediol Esters in Vegetable Oils.
[So] Source:J Agric Food Chem;66(4):999-1007, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During high-temperature refining of vegetable oils, 3-monochloropropanediol (3-MCPD) esters, possible carcinogens, are formed from acylglycerol in the presence of a chlorine source. To investigate organochlorine compounds in vegetable oils as possible precursors for 3-MCPD esters, we tested crude palm, soybean, rapeseed, sunflower, corn, coconut, and olive oils for the presence of organochlorine compounds. Having found them in all vegetable oils tested, we focused subsequent study on oil palm products. Analysis of the chlorine isotope mass pattern exhibited in high-resolution mass spectrometry enabled organochlorine compound identification in crude palm oils as constituents of wax esters, fatty acid, diacylglycerols, and sphingolipids, which are produced endogenously in oil palm mesocarp throughout ripening. Analysis of thermal decomposition and changes during refining suggested that these naturally present organochlorine compounds in palm oils and perhaps in other vegetable oils are precursors of 3-MCPD esters. Enrichment and dose-response showed a linear relationship to 3-MCPD ester formation and indicated that the sphingolipid-based organochlorine compounds are the most active precursors of 3-MCPD esters.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados/química
Óleos Vegetais/química
alfa-Cloridrina/química
[Mh] Termos MeSH secundário: Carcinógenos
Cloro/química
Ésteres/química
Contaminação de Alimentos
Manipulação de Alimentos
Glicerídeos/química
Óleo de Palmeira/química
alfa-Cloridrina/análise
alfa-Cloridrina/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carcinogens); 0 (Esters); 0 (Glycerides); 0 (Hydrocarbons, Chlorinated); 0 (Plant Oils); 4R7X1O2820 (Chlorine); 5QUO05548Z (Palm Oil); 96-24-2 (alpha-Chlorohydrin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04995


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[PMID]:28986081
[Au] Autor:Garcia-Heras MS; Arroyo B; Simmons RE; Camarero PR; Mateo R; Mougeot F
[Ad] Endereço:FitzPatrick Institute of African Ornithology, DST-NRF Centre of Excellence, University of Cape Town, Private Bag X3, Rondebosch 7701, South Africa. Electronic address: ms.garciaheras@gmail.com.
[Ti] Título:Blood concentrations of PCBs and DDTs in an avian predator endemic to southern Africa: Associations with habitat, electrical transformers and diet.
[So] Source:Environ Pollut;232:440-449, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Persistent pollutants such as organochlorine compounds (OCs) have been highlighted as a cause of population decline in avian predators. Understanding patterns of OCs contamination can be crucial for the conservation of affected species, yet little is known on these threats to African raptors. Here we report on OC concentrations in an endangered predator endemic to southern Africa, the Black Harrier Circus maurus. Blood samples were collected in 2012-2014 from wild nestlings (n = 90) and adults (n = 23) in south-western South Africa, where agriculture and urbanization have developed rapidly since the 1950s. Polychlorinated biphenyl (ΣPCB) and dichlorodiphenyltrichloroethane (ΣDDT, for p,p'-DDT + p,p'-DDE) were detected in 79% and 84% of sampled individuals, respectively, with varying concentrations among demographic groups: nestlings had significantly higher ΣPCB and p,p'-DDT concentrations than adults, while adults had higher levels of p,p'-DDE than nestlings. Levels of ΣPCB significantly increased with an index of electric transformer density, a measure of the number and power of electric transformers around active nests. We propose this index as a useful tool for assessing ΣPCB exposure risk in other wildlife. Levels of p,p'-DDE significantly increased with the proportion of wetlands within the breeding territory, and also with the proportion of bird biomass in the diet. No association was found between OC levels and the protected area status of nesting sites. Physiological effects of contaminants were also manifest in increased white blood cell counts with higher p,p'-DDT levels. Heterophil to lymphocyte ratio increased with higher ΣPCB levels, suggesting increased physiological stress and reduced immunity in contaminated individuals. Our results suggest that OCs are still a current cause of concern for endangered Black Harriers, as well as other sympatric predators.
[Mh] Termos MeSH primário: DDT/sangue
Exposição Dietética/análise
Resíduo Eletrônico
Monitoramento Ambiental
Poluentes Ambientais/sangue
Falconiformes/sangue
Bifenilos Policlorados/sangue
[Mh] Termos MeSH secundário: Adulto
África Austral
Animais
Aves
Diclorodifenil Dicloroetileno/sangue
Dieta/estatística & dados numéricos
Exposição Dietética/estatística & dados numéricos
Ecossistema
Seres Humanos
Hidrocarbonetos Clorados/sangue
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (Hydrocarbons, Chlorinated); 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene); CIW5S16655 (DDT); DFC2HB4I0K (Polychlorinated Biphenyls)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171008
[St] Status:MEDLINE


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[PMID]:29289283
[Au] Autor:Morin NAO; Andersson PL; Hale SE; Arp HPH
[Ad] Endereço:Norwegian Geotechnical Institute (NGI), P.O. Box 3930, Ullevål Stadion, N-0806 Oslo, Norway; Environmental and Food Laboratory of Vendée (LEAV), Department of Chemistry, Rond-point Georges Duval CS 80802, 85021 La Roche-sur-Yon, France. Electronic address: nicolasmorin@live.fr.
[Ti] Título:The presence and partitioning behavior of flame retardants in waste, leachate, and air particles from Norwegian waste-handling facilities.
[So] Source:J Environ Sci (China);62:115-132, 2017 Dec.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Flame retardants in commercial products eventually make their way into the waste stream. Herein the presence of flame retardants in Norwegian landfills, incineration facilities and recycling sorting/defragmenting facilities is investigated. These facilities handled waste electrical and electronic equipment (WEEE), vehicles, digestate, glass, combustibles, bottom ash and fly ash. The flame retardants considered included polybrominated diphenyl ethers (∑BDE-10) as well as dechlorane plus, polybrominated biphenyls, hexabromobenzene, pentabromotoluene and pentabromoethylbenzene (collectively referred to as ∑FR-7). Plastic, WEEE and vehicles contained the largest amount of flame retardants (∑BDE-10: 45,000-210,000µg/kg; ∑FR-7: 300-13,000µg/kg). It was hypothesized leachate and air concentrations from facilities that sort/defragment WEEE and vehicles would be the highest. This was supported for total air phase concentrations (∑BDE-10: 9000-195,000pg/m WEEE/vehicle facilities, 80-900pg/m in incineration/sorting and landfill sites), but not for water leachate concentrations (e.g., ∑BDE-10: 15-3500ng/L in WEEE/Vehicle facilities and 1-250ng/L in landfill sites). Landfill leachate exhibited similar concentrations as WEEE/vehicle sorting and defragmenting facility leachate. To better account for concentrations in leachates at the different facilities, waste-water partitioning coefficients, K were measured (for the first time to our knowledge for flame retardants). WEEE and plastic waste had elevated K compared to other wastes, likely because flame retardants are directly added to these materials. The results of this study have implications for the development of strategies to reduce exposure and environmental emissions of flame retardants in waste and recycled products through improved waste management practices.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Monitoramento Ambiental
Retardadores de Chama/análise
Instalações de Eliminação de Resíduos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Bromobenzenos/análise
Resíduo Eletrônico/análise
Éteres Difenil Halogenados/análise
Hidrocarbonetos Clorados/análise
Noruega
Plásticos
Bifenil Polibromatos/análise
Compostos Policíclicos/análise
Gerenciamento de Resíduos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Bromobenzenes); 0 (Flame Retardants); 0 (Halogenated Diphenyl Ethers); 0 (Hydrocarbons, Chlorinated); 0 (Plastics); 0 (Polybrominated Biphenyls); 0 (Polycyclic Compounds); 0 (Water Pollutants, Chemical); 0 (dechlorane plus); T01859XWIR (hexabromobenzene)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


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[PMID]:28460875
[Au] Autor:Muzyed SKI; Kucuksezgin F; Tuzmen N
[Ad] Endereço:Dokuz Eylul University, Institute of Marine Sciences and Technology, Inciralti, Izmir, Turkey.
[Ti] Título:Persistent organochlorine residues in fish and sediments collected from Eastern Aegean coast: Levels, occurrence and ecological risk.
[So] Source:Mar Pollut Bull;119(2):247-252, 2017 Jun 30.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organochlorines were determined in fish and sediment collected from Izmir and Çandarli Bays. The results indicated that ΣCyclodiens were generally predominant contaminants. In all samples, p,p'-DDE was the predominant DDT congener. Aroclors were found in noticeably higher levels than OCPs in sediment and the highest levels of Aroclors, OCPs were found in Nemrut which can be attributed to industrial activities. According to Sediment Quality Guidelines, DDTs were lower than the values that may cause adverse biological risk in sediment samples. Aroclor 1254 in sediments only exceeded the TEL value at Nemrut site. The maximum values of ΣOCPs were found in fish collected from Gülbahçe, while Aroclors were measured in Aliaga. According to related indices, results indicate no recent influxes of DDT in the sampling areas. The estimated daily intake of DDTs, Aroclor1254 were below the acceptable daily intake level recommended by FAO/WHO.
[Mh] Termos MeSH primário: Peixes
Sedimentos Geológicos
Hidrocarbonetos Clorados/análise
[Mh] Termos MeSH secundário: Animais
Monitoramento Ambiental
Hidrocarbonetos Clorados/farmacocinética
Praguicidas
Risco
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hydrocarbons, Chlorinated); 0 (Pesticides); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28745352
[Au] Autor:Wang P; Zhang Q; Li Y; Matsiko J; Zhang Y; Jiang G
[Ad] Endereço:State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. qhzhang@rcees.ac.cn.
[Ti] Título:Airborne persistent toxic substances (PTSs) in China: occurrence and its implication associated with air pollution.
[So] Source:Environ Sci Process Impacts;19(8):983-999, 2017 Aug 16.
[Is] ISSN:2050-7895
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In recent years, China suffered from extensive air pollution due to the rapidly expanding economic and industrial developments. Its severe impact on human health has raised great concern currently. Persistent toxic substances (PTSs), a large group of environmental pollutants, have also received much attention due to their adverse effects on both the ecosystem and public health. However, limited studies have been conducted to reveal the airborne PTSs associated with air pollution at the national scale in China. In this review, we summarized the occurrence and variation of airborne PTSs in China, especially in megacities. These PTSs included polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), halogenated flame retardants (HFRs), perfluorinated compounds (PFCs), organochlorine pesticides (OCPs), polycyclic aromatic hydrocarbons (PAHs) and heavy metals. The implication of their occurrence associated with air pollution was discussed, and the emission source of these chemicals was concluded. Most reviewed studies have been conducted in east and south China with more developed economy and industry. Severe contamination of airborne PTSs generally occurred in megacities with large populations, such as Guangzhou, Shanghai and Beijing. However, the summarized results suggested that industrial production and product consumption are the major sources of most PTSs in the urban environment, while unintentional emission during anthropogenic activities is an important contributor to airborne PTSs. It is important that fine particles serve as a major carrier of most airborne PTSs, which facilitates the long-range atmospheric transport (LRAT) of PTSs, and therefore, increases the exposure risk of the human body to these pollutants. This implied that not only the concentration and chemical composition of fine particles but also the absorbed PTSs are of particular concern when air pollution occurs.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/análise
Monitoramento Ambiental/métodos
Substâncias Perigosas/análise
Hidrocarbonetos Clorados/análise
Metais Pesados/análise
Hidrocarbonetos Aromáticos Policíclicos/análise
[Mh] Termos MeSH secundário: China
Cidades
Seres Humanos
Urbanização
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Air Pollutants); 0 (Hazardous Substances); 0 (Hydrocarbons, Chlorinated); 0 (Metals, Heavy); 0 (Polycyclic Aromatic Hydrocarbons)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1039/c7em00187h


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[PMID]:28979999
[Au] Autor:Deng G; Moran EP; Cheng R; Matlock G; Zhou K; Moran D; Chen D; Yu Q; Ma JX
[Ad] Endereço:State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
[Ti] Título:Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy.
[So] Source:Invest Ophthalmol Vis Sci;58(12):5030-5042, 2017 Oct 01.
[Is] ISSN:1552-5783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: Clinical studies have shown that peroxisome proliferator-activated receptor alpha (PPARα) agonist fenofibrate has therapeutic effects on diabetic retinopathy (DR). The purpose of this study was to identify a novel PPARα agonist and to evaluate its beneficial effects on DR. Methods: The transcriptional activity of PPARα was measured by a luciferase-based promoter assay. TUNEL was used to evaluate apoptosis in retinal precursor cells (R28). Diabetes was induced in rats by injection of streptozotocin. Retinal inflammation was examined using leukostasis assay, and retinal vascular leakage was measured using permeability assay. Retinal function was measured using electroretinogram (ERG) recording, and retinal apoptosis was quantified using the cell death ELISA. The anti-angiogenic effect was evaluated in the oxygen-induced retinopathy (OIR) model. Results: A compound, 7-chloro-8-methyl-2-phenylquinoline-4-carboxylic acid (Y-0452), with a chemical structure distinct from existing PPARα agonists, activated PPARα transcriptional activity and upregulated PPARα expression. Y-0452 significantly inhibited human retinal capillary endothelial cell migration and tube formation. The compound also protected R28 cells against apoptosis and inhibited NF-κB signaling in R28 cells exposed to palmitate. In diabetic rats, Y-0452 ameliorated leukostasis and vascular leakage in the retina. In addition, Y-0452 preserved the retinal function and reduced retinal cell death in diabetic rats. Y-0452 also alleviated retinal neovascularization in the OIR model. Conclusions: Y-0452 is a novel PPARα agonist and has therapeutic potential for DR.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/uso terapêutico
Diabetes Mellitus Experimental/tratamento farmacológico
Retinopatia Diabética/tratamento farmacológico
Hidrocarbonetos Clorados/uso terapêutico
PPAR alfa/agonistas
Quinolinas/uso terapêutico
Neovascularização Retiniana/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Western Blotting
Permeabilidade Capilar/efeitos dos fármacos
Linhagem Celular
Movimento Celular
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[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Hydrocarbons, Chlorinated); 0 (NF-kappa B); 0 (PPAR alpha); 0 (Quinolines); 0 (Y-0452); 5W494URQ81 (Streptozocin); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1167/iovs.16-21402


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[PMID]:28953660
[Au] Autor:Xie F; Zhang X; Xie L
[Ad] Endereço:Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
[Ti] Título:Prognostic value of serum zinc levels in patients with acute HC/zinc chloride smoke inhalation.
[So] Source:Medicine (Baltimore);96(39):e8156, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Hexachloroethane (HC)/zinc chloride (ZnCl, smoke bomb) exposure in the military setting results in lung injury which is uncommon and has been rarely described in previous studies. The aim of this study is to investigate the correlation between the serum zinc in patients with HC/ZnCl smoke inhalation lung injury and disease severity. A total of 15 patients with HC/ZnCl-related conditions were recruited in this study. The serum zinc level and the pulmonary function tests and liver function tests including total lung capacity (TLC), forced vital capacity (FVC), forced expiratory pressure in 1 second (FEV1), alanine aminotransferase (ALT), and aspartate transaminase (AST) were analyzed. Eleven cases had mild clinical manifestations. Four cases rapidly developed features typical of severe adult respiratory distress syndrome. The level of serum zinc was increased, but FVC, FEV1, and TLC was decreased significantly in the moderate and severe cases. In addition, the serum zinc level correlated well with the TLC, FVC, and FEV1 (r = -0.587, -0.626, -0.617, respectively; P = .027, .017, .019, respectively). The 4 cases in moderate and severe group had delayed impairment of liver functions after the accident. This study suggested that the serum zinc level may be associated with the severity of lung and liver injuries after HC/ZnCl smoke inhalation.
[Mh] Termos MeSH primário: Bombas (Dispositivos Explosivos)
Doença Hepática Induzida por Substâncias e Drogas
Cloretos
Etano/análogos & derivados
Hidrocarbonetos Clorados
Lesão Pulmonar
Síndrome do Desconforto Respiratório do Adulto
Lesão por Inalação de Fumaça
Compostos de Zinco
Zinco/sangue
[Mh] Termos MeSH secundário: Adulto
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Doença Hepática Induzida por Substâncias e Drogas/sangue
Doença Hepática Induzida por Substâncias e Drogas/diagnóstico
Doença Hepática Induzida por Substâncias e Drogas/etiologia
China
Cloretos/química
Cloretos/toxicidade
Etano/química
Etano/toxicidade
Feminino
Seres Humanos
Hidrocarbonetos Clorados/química
Hidrocarbonetos Clorados/toxicidade
Lesão Pulmonar/sangue
Lesão Pulmonar/induzido quimicamente
Lesão Pulmonar/diagnóstico
Masculino
Militares
Valor Preditivo dos Testes
Prognóstico
Síndrome do Desconforto Respiratório do Adulto/sangue
Síndrome do Desconforto Respiratório do Adulto/diagnóstico
Síndrome do Desconforto Respiratório do Adulto/etiologia
Testes de Função Respiratória
Índice de Gravidade de Doença
Fumaça/análise
Lesão por Inalação de Fumaça/sangue
Lesão por Inalação de Fumaça/diagnóstico
Lesão por Inalação de Fumaça/etiologia
Estatística como Assunto
Compostos de Zinco/química
Compostos de Zinco/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Hydrocarbons, Chlorinated); 0 (Smoke); 0 (Zinc Compounds); 86Q357L16B (zinc chloride); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); G30K3QQT4J (hexachloroethane); J41CSQ7QDS (Zinc); L99N5N533T (Ethane)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170928
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008156



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