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[PMID]:28723966
[Au] Autor:Yehya S; Delannoy M; Fournier A; Baroudi M; Rychen G; Feidt C
[Ad] Endereço:Université de Lorraine, INRA USC 340, UR AFPA, 2 avenue de la Forêt de Haye TSA, VandÅ“uvre-lès-Nancy, France.
[Ti] Título:Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids.
[So] Source:PLoS One;12(7):e0179548, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chlordecone (Kepone) (CLD) is a highly persistent pesticide which was extensively used in the French West Indies; high levels of CLD can still currently be found in large agricultural areas. As CLD transfers from soil to animals mainly via involuntary ingestion, the consumption of foodstuffs derived from animals raised in contaminated areas may significantly contribute to exposure of humans to CLD. The present study was designed to test the efficacy of two different activated carbons (ACs) sources in limiting CLD transfer from soil to animal. Three soils (ASs) were prepared according to the OECD guideline 207. One standard soil (SS) lacking AC, and two modified preparations of SS supplemented with 2% coconut-based activated carbon (ORBO), SSO or with 2% lignite-based one (DARCO), SSD. All three soils were spiked with 10 µg of kepone per g of dry matter and aged for three weeks. This study involved 15 goat kids randomly assigned to the 3 experimental groups (n = 5/group), which were fed the experimental matrices at an exposure dose of 10 µg CLD per kg of body weight per day. After 21 d of oral exposure, CLD in adipose tissue and liver were analysed by LC-MS-MS. A significant decrease of 63.7% and 74.7% of CLD concentrations in adipose tissue and liver, respectively, were obtained from animals exposed using SS containing DARCO as compared to those receiving only SS. Decreases in CLD levels of 98.2% (adipose tissue) and 98.7% (liver) were obtained for animals exposed using SS containing ORBO. This study leads us to conclude that (i) the presence of AC in CLD-contaminated soil strongly reduces CLD bioavailability, and (ii) the efficacy depends on the nature and characteristics of the AC used.
[Mh] Termos MeSH primário: Tecido Adiposo/química
Carvão Vegetal
Clordecona/análise
Fígado/química
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Adsorção
Animais
Disponibilidade Biológica
Ingestão de Alimentos
Cabras
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 0 (Soil Pollutants); 16291-96-6 (Charcoal); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179548


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[PMID]:28641228
[Au] Autor:Mottes C; Lesueur Jannoyer M; Le Bail M; Guéné M; Carles C; Malézieux E
[Ad] Endereço:Cirad, UPR HortSys, F-97285, Le Lamentin, Martinique, France. Electronic address: charles.mottes@cirad.fr.
[Ti] Título:Relationships between past and present pesticide applications and pollution at a watershed outlet: The case of a horticultural catchment in Martinique, French West Indies.
[So] Source:Chemosphere;184:762-773, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The understanding of factors affecting pesticide transfers to catchment outlet is still at a very early stage in tropical context, and especially on tropical volcanic context. We performed on-farm pesticide use surveys during 87 weeks and monitored pesticides in water weekly during 67 weeks at the outlet of a small catchment in Martinique. We identified three types of pollution. First, we showed long-term chronic pollution by chlordecone, diuron and metolachlor resulting from horticultural practices applied 5-20 years ago (quantification frequency higher than 80%). Second, we showed peak pollution. High amounts of propiconazole and fosthiazate applied at low frequencies caused river pollution peaks for weeks following a single application. Low amounts of diquat and diazinon applied at low frequencies also caused pollution peaks. The high amounts of glyphosate applied at high frequency resulted into pollution peaks by glyphosate and aminomethylphosphonic acid (AMPA) in 6 and 20% of the weeks. Any intensification of their uses will result in higher pollution levels. Third, relatively low amounts of glufosinate-ammonium, difenoconazol, spinosad and metaldehyde were applied at high frequencies. Unexpectedly, such pesticides remained barely detected (<1.5%) or undetected in water samples. We showed that AMPA, fosthiazate and propiconazole have serious leaching potential. They might result in future chronic pollution of shallow aquifers alimenting surface water. We prove that to avoid the past errors and decrease the risk of long-term pollution of water resources, it is urgent to reduce or stop the use of pesticides with leaching potential by changing agricultural practices.
[Mh] Termos MeSH primário: Agricultura
Monitoramento Ambiental
Praguicidas/análise
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Clordecona/análise
Água Subterrânea
Martinica
Rios
Recursos Hídricos
Índias Ocidentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pesticides); 0 (Water Pollutants, Chemical); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE


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[PMID]:28371731
[Au] Autor:Lafontaine A; Baiwir D; Joaquim-Justo C; De Pauw E; Lemoine S; Boulangé-Lecomte C; Forget-Leray J; Thomé JP; Gismondi E
[Ad] Endereço:University of Liège, Laboratory of Animal Ecology and Ecotoxicology (LEAE) - Freshwater and OceaniC sciences Unit of reSearch (FOCUS), Chemistry Institute, Bât. B6C, 11 allée du 6 Août, B-4000 Sart-Tilman, Belgium. Electronic address: Anne.Lafontaine@ulg.ac.be.
[Ti] Título:Proteomic response of Macrobrachium rosenbergii hepatopancreas exposed to chlordecone: Identification of endocrine disruption biomarkers?
[So] Source:Ecotoxicol Environ Saf;141:306-314, 2017 Jul.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present work is the first study investigating the impacts of chlordecone, an organochlorine insecticide, on the proteome of the decapod crustacean Macrobrachium rosenbergii, by gel-free proteomic analysis. The hepatopancreas protein expression variations were analysed in organisms exposed to three environmental relevant concentrations of chlordecone (i.e. 0.2, 2 and 20µg/L). Results revealed that 62 proteins were significantly up- or down-regulated in exposed prawns compared to controls. Most of these proteins are involved in important physiological processes such as ion transport, defense mechanisms and immune system, cytoskeleton dynamics, or protein synthesis and degradation. Moreover, it appears that 6% of the deregulated protein are involved in the endocrine system and in the hormonal control of reproduction or development processes of M. rosenbergii (e.g. vitellogenin, farnesoic acid o-methyltransferase). These results indicate that chlordecone is potentially an endocrine disruptor compound for decapods, as already observed in vertebrates. These protein modifications could lead to disruptions of M. rosenbergii growth and reproduction, and therefore of the fitness population on the long-term. Besides, these disrupted proteins could be suggested as biomarkers of exposure for endocrine disruptions in invertebrates. However, further investigations are needed to complete understanding of action mechanisms of chlordecone on proteome and endocrine system of crustaceans.
[Mh] Termos MeSH primário: Clordecona/toxicidade
Disruptores Endócrinos/toxicidade
Hepatopâncreas/efeitos dos fármacos
Inseticidas/toxicidade
Palaemonidae/efeitos dos fármacos
Proteoma/metabolismo
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Relação Dose-Resposta a Droga
Hepatopâncreas/metabolismo
Metiltransferases/metabolismo
Palaemonidae/metabolismo
Proteômica
Reprodução/efeitos dos fármacos
Vitelogeninas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Endocrine Disruptors); 0 (Insecticides); 0 (Proteome); 0 (Vitellogenins); EC 2.1.1.- (Methyltransferases); EC 2.1.1.- (farnesoic acid O-methyltransferase); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE


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[PMID]:28161271
[Au] Autor:Clostre F; Letourmy P; Lesueur-Jannoyer M
[Ad] Endereço:Cirad, UPR fonctionnement agroécologique et performances des systèmes de culture horticoles (HortSys), F-97285, Le Lamentin, Martinique, France. Electronic address: florence.clostre@cirad.fr.
[Ti] Título:Soil thresholds and a decision tool to manage food safety of crops grown in chlordecone polluted soil in the French West Indies.
[So] Source:Environ Pollut;223:357-366, 2017 Apr.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Due to the persistent pollution of soils by an organochlorine, chlordecone (CLD also known as Kepone ) in the French West Indies, some crops may be contaminated beyond the European regulatory threshold, the maximum residue limit (MRL). Farmers need to be able to foresee the risk of not complying with the regulatory threshold in each field and for each crop, if not, farmers whose fields are contaminated would have to stop cultivating certain crops in the fields concerned. To help farmers make the right choices, we studied the relationship between contamination of the soil and contamination of crops. We showed that contamination of a crop by CLD depended on the crop concerned, the soil CLD content and the type of soil. We grouped crop products in three categories: (i) non-uptakers and low-uptakers, (ii) medium-uptakers, and (iii) high-uptakers, according to their level of contamination and the resulting risk of exceeding MRL. Using a simulation model, we computed the soil threshold required to ensure the risk of not complying with MRL was sufficiently low for each crop product and soil type. Threshold values ranged from 0.02 µgkg for dasheen grown in nitisol to 1.7 µgkg for yam grown in andosol in the high-uptake category, and from 1 µgkg for lettuce grown in nitisol to 45 µgkg for the leaves of spring onions grown in andosol in the medium-uptake category. Contamination of non-uptakers and low-uptakers did not depend on soil contamination. With these results, we built an easy-to-use decision support tool based on two soil thresholds (0.1 and 1 µgkg ) to enable growers to adapt their cropping system and hence to be able to continue farming.
[Mh] Termos MeSH primário: Clordecona/análise
Produtos Agrícolas/química
Técnicas de Apoio para a Decisão
Inocuidade dos Alimentos/métodos
Inseticidas/análise
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Agricultura/métodos
Produtos Agrícolas/crescimento & desenvolvimento
Produtos Agrícolas/metabolismo
Modelos Teóricos
Índias Ocidentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Soil); 0 (Soil Pollutants); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170206
[St] Status:MEDLINE


  5 / 484 MEDLINE  
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[PMID]:28069088
[Au] Autor:Jurjanz S; Collas C; Lastel ML; Godard X; Archimède H; Rychen G; Mahieu M; Feidt C
[Ad] Endereço:1UR Animal et Fonctionnalités des Produits Animaux (USC340),INRA-Université de Lorraine,2 avenue de la Forêt de Haye,TSA 40602,54518 VandÅ“uvre-lès-Nancy Cedex,France.
[Ti] Título:Evaluation of soil intake by growing Creole young bulls in common grazing systems in humid tropical conditions.
[So] Source:Animal;11(8):1363-1371, 2017 Aug.
[Is] ISSN:1751-732X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Soil is the main matrix which contributes to the transfer of environmental pollutants to animals and consequently into the food chain. In the French West Indies, chlordecone, a very persistent organochlorine pesticide, has been widely used on banana growing areas and this process has resulted in a long-term pollution of the corresponding soils. Domestic outside-reared herbivores are exposed to involuntary soil intake, and tethered grazing commonly used in West Indian systems can potentially favour their exposure to chlordecone. Thus, it appears necessary to quantify to what extent grazing conditions will influence soil intake. This experiment consisted of a cross-over design with two daily herbage allowance (DHA) grazed alternatively. Six young Creole bulls were distributed into two groups (G1 and G2) according to their BW. The animals were individually tethered and grazed on a restrictive (RES) or non-restrictive (NRES) levels of DHA during two successive 10-days periods. Each bull progressed on a new circular area every day. The two contrasting levels of DHA (P0.05) due to the lower DMI of RES compared with NRES treatment.
[Mh] Termos MeSH primário: Criação de Animais Domésticos/métodos
Bovinos/crescimento & desenvolvimento
Clordecona/análise
Comportamento Alimentar/fisiologia
Poluentes do Solo/análise
Solo/química
[Mh] Termos MeSH secundário: Animais
Estudos Cross-Over
Inseticidas/análise
Masculino
Clima Tropical
Índias Ocidentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Soil); 0 (Soil Pollutants); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1017/S1751731116002755


  6 / 484 MEDLINE  
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[PMID]:28039835
[Au] Autor:Fournier A; Feidt C; Lastel ML; Archimede H; Thome JP; Mahieu M; Rychen G
[Ad] Endereço:Université de Lorraine, INRA, USC 340, UR AFPA, 2 avenue de la Forêt de Haye, TSA 40602, 54518, VandÅ“uvre-lès-Nancy Cedex, France. Electronic address: agnes.fournier@univ-lorraine.fr.
[Ti] Título:Toxicokinetics of chlordecone in goats: Implications for risk management in French West Indies.
[So] Source:Chemosphere;171:564-570, 2017 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. CLD is known to be potentially transferred towards animal products of animals reared outdoors, mainly through accidental soil ingestion. Several studies indicate that soil bound CLD is bioavailable when administered to farm animals. Currently there is a need to quantify the level of CLD absorption and its toxicokinetic characteristics in the ruminant and particularly in the goat. These are considered as important farm species in the French West Indies. The objective of this study was to evaluate the absorption rate and the half-life of CLD in the non-lactating goat. The goats were administered either intravenously (i.v., n = 6) or orally (p.o., n = 6) one dose (1 mg kg body weight) of CLD. Blood samples were collected at defined times up to 160 days post-dosing. CLD was analyzed in serum by high-resolution gas chromatography. A comparison of the area under the serum concentration-time curves (AUC) showed that the i.v. route is equivalent to the oral route. Thus, CLD is considered almost completely absorbed after p.o. administration, as shown by the mean absolute bioavailability. The comparison between the pharmacokinetic profiles of CLD following oral and intravenous dose showed a difference during the first 14 days and a similar kinetic after this period. The half-life of CLD in serum was close to 20 days. These results highlight a possible strategy of decontamination due to the short half-life of CLD, obtained in dry goats that did not excrete fat matter.
[Mh] Termos MeSH primário: Clordecona/farmacocinética
Clordecona/toxicidade
Cabras
Inseticidas/farmacocinética
Inseticidas/toxicidade
Poluentes do Solo/farmacocinética
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Animais
Clordecona/sangue
Feminino
Cabras/sangue
Cabras/metabolismo
Meia-Vida
Inseticidas/sangue
Medição de Risco
Poluentes do Solo/sangue
Toxicocinética
Índias Ocidentais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Soil Pollutants); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170101
[St] Status:MEDLINE


  7 / 484 MEDLINE  
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[PMID]:28032285
[Au] Autor:Legrand E; Boulangé-Lecomte C; Restoux G; Trémolet G; Duflot A; Forget-Leray J
[Ad] Endereço:Normandie Univ, ULHN, UMR-I 02 SEBIO, FR CNRS 3730 SCALE BP 1123, F-76063, Le Havre, France.
[Ti] Título:Individual and mixture acute toxicity of model pesticides chlordecone and pyriproxyfen in the estuarine copepod Eurytemora affinis.
[So] Source:Environ Sci Pollut Res Int;24(6):5976-5984, 2017 Feb.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Due to the increase in the use of phytosanitary products during the last few decades, the importance to study the effect of pesticide mixtures has been established. In this study, we investigated the acute toxicity of two model insecticides, chlordecone (CLD) and pyriproxyfen (PXF), alone and in mixtures, in the estuarine copepod Eurytemora affinis. After 48 h of exposure, the relative LC50 were 73.24 and 131.61 µg/L for PXF and CLD, respectively. The lower concentration tested (10 µg/L) did not affect the mortality of E. affinis whatever the considered chemical compound. To understand the interaction between compounds in mixture, the results were fitted to the concentration addition, Vølund, and Hewlett models. The best fit was obtained with the Hewlett model, suggesting a synergistic effect of the mixture.
[Mh] Termos MeSH primário: Clordecona/toxicidade
Copépodes/efeitos dos fármacos
Inseticidas/toxicidade
Piridinas/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Copépodes/crescimento & desenvolvimento
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Pyridines); 0 (Water Pollutants, Chemical); 3Q9VOR705O (pyriproxyfen); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-016-8294-5


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[PMID]:28012669
[Au] Autor:Zhang M; Engelhardt I; Simunek J; Bradford SA; Kasel D; Berns AE; Vereecken H; Klumpp E
[Ad] Endereço:Agrosphere Institute (IBG-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany; Institute for Environmental Research (Biology V), RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. Electronic address: m.zhang@fz-juelich.de.
[Ti] Título:Co-transport of chlordecone and sulfadiazine in the presence of functionalized multi-walled carbon nanotubes in soils.
[So] Source:Environ Pollut;221:470-479, 2017 Feb.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Batch and saturated soil column experiments were conducted to investigate sorption and mobility of two C-labeled contaminants, the hydrophobic chlordecone (CLD) and the sulfadiazine (SDZ), in the absence or presence of functionalized multi-walled carbon nanotubes (MWCNTs). The transport behaviors of CLD, SDZ, and MWCNTs were studied at environmentally relevant concentrations (0.1-10 mg L ) and they were applied in the column studies at different times. The breakthrough curves and retention profiles were simulated using a numerical model that accounted for the advective-dispersive transport of all compounds, attachment/detachment of MWCNTs, equilibrium and kinetic sorption of contaminants, and co-transport of contaminants with MWCNTs. The experimental results indicated that the presence of mobile MWCNTs facilitated remobilization of previously deposited CLD and its co-transport into deeper soil layers, while retained MWCNTs enhanced SDZ deposition in the topsoil layers due to the increased adsorption capacity of the soil. The modeling results then demonstrated that the mobility of engineered nanoparticles (ENPs) in the environment and the high affinity and entrapment of contaminants to ENPs were the main reasons for ENP-facilitated contaminant transport. On the other hand, immobile MWCNTs had a less significant impact on the contaminant transport, even though they were still able to enhance the adsorption capacity of the soil.
[Mh] Termos MeSH primário: Clordecona/análise
Modelos Químicos
Nanotubos de Carbono/química
Poluentes do Solo/análise
Sulfadiazina/análise
[Mh] Termos MeSH secundário: Adsorção
Solo/química
Poluentes do Solo/química
Sulfadiazina/química
Simportadores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Nanotubes, Carbon); 0 (Soil); 0 (Soil Pollutants); 0 (Symporters); 0N7609K889 (Sulfadiazine); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161226
[St] Status:MEDLINE


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[PMID]:27560981
[Au] Autor:Hervé D; Costet N; Kadhel P; Rouget F; Monfort C; Thomé JP; Multigner L; Cordier S
[Ad] Endereço:INSERM, IRSET, UMR 1085, Rennes, France; University Rennes 1, Rennes, France.
[Ti] Título:Prenatal exposure to chlordecone, gestational weight gain, and birth weight in a Guadeloupean birth cohort.
[So] Source:Environ Res;151:436-444, 2016 Nov.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chlordecone is a persistent organochlorine insecticide with well-defined estrogenic properties. It was intensively used in the French West Indies until 1993 to control the banana root borer. Because of the long-term contamination of soils and water, the population is currently exposed to chlordecone through food consumption. Chlordecone has been found in the blood of pregnant women and in cord blood. It has been shown to be an endocrine-disrupting chemical and exposure during pregnancy may affect fetal growth. OBJECTIVES: The objective of our study was to examine the association between prenatal exposure to chlordecone and fetal growth based on the TIMOUN birth cohort conducted in Guadeloupe, with a focus on the potential modification of this relationship by maternal body mass index (BMI) and gestational weight gain (GWG). METHODS: Chlordecone was determined in cord plasma at birth in 593 babies. Birth weight was the indicator of fetal growth. Maternal pre-pregnancy BMI and GWG were determined. Adherence to GWG recommendations of the US Institute of Medicine based on maternal pre-pregnancy BMI was assessed. Birth weight was analyzed relative to cord blood chlordecone levels using linear and non-linear regression models. RESULTS: Overall chlordecone in cord blood was not associated with birth weight, but we found an interaction between chlordecone exposure with GWG and adherence to GWG recommendations. After stratification by GWG, we found a significant U-shaped association between birth weight and chlordecone exposure, within the upper quartiles of GWG or excessive GWG. CONCLUSION: Chlordecone exposure may affect fetal growth, particularly when excessive GWG is present.
[Mh] Termos MeSH primário: Peso ao Nascer/efeitos dos fármacos
Clordecona/toxicidade
Desenvolvimento Fetal/efeitos dos fármacos
Efeitos Tardios da Exposição Pré-Natal
[Mh] Termos MeSH secundário: Adolescente
Adulto
Clordecona/sangue
Feminino
Guadalupe
Seres Humanos
Meia-Idade
Gravidez
Estudos Prospectivos
Ganho de Peso/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160826
[St] Status:MEDLINE


  10 / 484 MEDLINE  
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Fotocópia
[PMID]:27470247
[Au] Autor:Lafontaine A; Hanikenne M; Boulangé-Lecomte C; Forget-Leray J; Thomé JP; Gismondi E
[Ad] Endereço:Laboratory of Animal Ecology and Ecotoxicology (LEAE), Centre of Analytical Research and Technology (CART), University of Liège, 15 Allée du Six Aout, 4000, Liège, Belgium. anne.lafontaine@ulg.ac.be.
[Ti] Título:Vitellogenin and vitellogenin receptor gene expression and 20-hydroxyecdysone concentration in Macrobrachium rosenbergii exposed to chlordecone.
[So] Source:Environ Sci Pollut Res Int;23(20):20661-20671, 2016 Oct.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Chlordecone is a persistent organochlorine pesticide widely used in Guadeloupe (French West Indies) to control the banana weevil Cosmopolites sordidus. Although it was previously highlighted that chlordecone may affect the reproduction and growth of vertebrate species, little information is available on the chlordecone effects in invertebrates. The present study investigated the effects of chlordecone on a hormone and a protein having key roles in reproduction and growth of the decapod crustacean Macrobrachium rosenbergii, by measuring the 20-hydroxyecdysone concentration, vitellogenin, and vitellogenin receptor gene expression, as well as the bioconcentration of chlordecone in exposed prawns. First, the results revealed that chlordecone was accumulated in M. rosenbergii. Then, it was found that Vg and VgR gene expression were increased in male and female M. rosenbergii exposed to chlordecone for 90 and 240 days, while the 20-hydroxyecdysone concentrations were decreased. This work suggests that chlordecone accumulates in prawn tissues and could affect key molecules involved in the reproduction and the growth of the invertebrate M. rosenbergii. However, many questions remain unresolved regarding the impacts of chlordecone on growth and reproduction and the signaling pathways responsible for these effects, as well as the potential role of confounding factors present in in situ studies.
[Mh] Termos MeSH primário: Proteínas de Artrópodes/metabolismo
Clordecona/toxicidade
Ecdisterona/metabolismo
Proteínas do Ovo/metabolismo
Inseticidas/toxicidade
Palaemonidae/efeitos dos fármacos
Receptores de Superfície Celular/metabolismo
Vitelogeninas/metabolismo
[Mh] Termos MeSH secundário: Animais
Disruptores Endócrinos/toxicidade
Feminino
Expressão Gênica/efeitos dos fármacos
Masculino
Palaemonidae/metabolismo
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arthropod Proteins); 0 (Egg Proteins); 0 (Endocrine Disruptors); 0 (Insecticides); 0 (Receptors, Cell Surface); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 0 (vitellogenin receptor); 5289-74-7 (Ecdysterone); RG5XJ88UDF (Chlordecone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE



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