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[PMID]:29267660
[Au] Autor:Ribeiro-Júnior O; Borba AM; Alves CAF; Gouveia MM; Deboni MCZ; Naclério-Homem MDG
[Ad] Endereço:Universidade de São Paulo - USP, School of Dentistry, Department of Oral & Maxillofacial Surgery, Traumatology and Prosthesis, São Paulo, SP, Brazil.
[Ti] Título:Reclassification and treatment of odontogenic keratocysts: A cohort study.
[So] Source:Braz Oral Res;31:e98, 2017 Dec 18.
[Is] ISSN:1807-3107
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The odontogenic keratocyst (OKC) is a recurrent cyst that has been recently reclassified from an odontogenic tumor to an odontogenic cyst. The aim of the present study was to investigate its treatment and address issues related to its association with nevoid basal cell carcinoma syndrome (NBCCS). Lesions from the cohort of patients included in the present study consisted of 40 OKCs, of which 27 lesions were treated by enucleation (GE) and 13 underwent decompression (GD). Complementary treatment occurred in 38 (95%) lesions, of which 10 underwent isolated peripheral ostectomy (GO) and 28 underwent peripheral ostectomy combined with Carnoy's solution (GC). Thirteen lesions were associated with NBCCS (GS), while the others (n=27) were non-syndromic lesions (GnS). The recurrence-free periods (RFP) in the sample groups were compared using the Kaplan-Meier function and log-rank test at a significance level of 5% (p < 0.05) and were used to calculate the cumulative risk of recurrence (CRR) in each postoperative year. During the follow-up period, which had a mean of 43.5 months (range: 12-102 months), six (15%) recurrences were diagnosed. There was no significant difference among the RFP for the compared groups (p > 0.05) or increased CRR for the decompression (15.4%) over five years. Application of Carnoy's solution did not increase the efficacy of the peripheral ostectomy, but was related to a CRR of 0% for the syndromic lesions over five years. Therefore, 1) decompression did not increase the recurrence risk; 2) peripheral ostectomy demonstrated a similar efficacy as the combination with Carnoy's solution; 3) the association of NBCCS did not seem to significantly influence OKC recurrence; and 4) syndromic lesions seem to behave in the same manner as non-syndromic lesions when submitted to complementary treatments.
[Mh] Termos MeSH primário: Síndrome do Nevo Basocelular/classificação
Síndrome do Nevo Basocelular/cirurgia
Cistos Odontogênicos/classificação
Cistos Odontogênicos/cirurgia
[Mh] Termos MeSH secundário: Ácido Acético/uso terapêutico
Adolescente
Adulto
Idoso
Criança
Clorofórmio/uso terapêutico
Descompressão Cirúrgica/métodos
Etanol/uso terapêutico
Feminino
Seres Humanos
Masculino
Doenças Mandibulares
Doenças Maxilares
Meia-Idade
Tumores Odontogênicos/classificação
Tumores Odontogênicos/cirurgia
Osteotomia/métodos
Fotografia
Recidiva
Estudos Retrospectivos
Medição de Risco
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carnoy's solution); 3K9958V90M (Ethanol); 7V31YC746X (Chloroform); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE


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[PMID]:29292470
[Au] Autor:Kehelpannala C; Kumar NS; Jayasinghe L; Araya H; Fujimoto Y
[Ad] Endereço:National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka.
[Ti] Título:Naphthoquinone Metabolites Produced by Monacrosporium ambrosium, the Ectosymbiotic Fungus of Tea Shot-Hole Borer, Euwallacea fornicatus, in Stems of Tea, Camellia sinensis.
[So] Source:J Chem Ecol;44(1):95-101, 2018 Jan.
[Is] ISSN:1573-1561
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The tea shot-hole borer beetle (TSHB, Euwallacea fornicatus) causes serious damage in plantations of tea, Camellia sinensis var. assamica, in Sri Lanka and South India. TSHB is found in symbiotic association with the ambrosia fungus, Monacrosporium ambrosium (syn. Fusarium ambrosium), in galleries located within stems of tea bushes. M. ambrosium is known to be the sole food source of TSHB. Six naphthoquinones produced during spore germination in a laboratory culture broth of M. ambrosium were isolated and identified as dihydroanhydrojavanicin, anhydrojavanicin, javanicin, 5,8-dihydroxy-2-methyl-3-(2-oxopropyl)naphthalene-1,4-dione, anhydrofusarubin and solaniol. Chloroform extracts of tea stems with red-colored galleries occupied by TSHB contained UV active compounds similar to the above naphthoquinones. Laboratory assays demonstrated that the combined ethyl acetate extracts of the fungal culture broth and mycelium inhibited the growth of endophytic fungi Pestalotiopsis camelliae and Phoma multirostrata, which were also isolated from tea stems. Thus, pigmented naphthoquinones secreted by M. ambrosium during spore germination may prevent other fungi from invading TSHB galleries in tea stems. The antifungal nature of the naphthoquinone extract suggests that it protects the habitat of TSHB. We propose that the TSHB fungal ectosymbiont M. ambrosium provides not only the food and sterol skeleton necessary for the development of the beetle during its larval stages, but also serves as a producer of fungal inhibitors that help to preserve the purity of the fungal garden of TSHB.
[Mh] Termos MeSH primário: Ascomicetos/química
Camellia sinensis/microbiologia
Coleópteros/microbiologia
Naftoquinonas/análise
[Mh] Termos MeSH secundário: Animais
Antifúngicos/química
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Ascomicetos/efeitos dos fármacos
Ascomicetos/fisiologia
Camellia sinensis/crescimento & desenvolvimento
Clorofórmio/química
Ecossistema
Espectroscopia de Ressonância Magnética
Naftoquinonas/isolamento & purificação
Naftoquinonas/farmacologia
Caules de Planta/química
Caules de Planta/microbiologia
Esporos Fúngicos/química
Esporos Fúngicos/crescimento & desenvolvimento
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Naphthoquinones); 7V31YC746X (Chloroform)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1007/s10886-017-0913-1


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[PMID]:28962563
[Au] Autor:Tamrat Y; Nedi T; Assefa S; Teklehaymanot T; Shibeshi W
[Ad] Endereço:Department of pharmacology and clinical pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
[Ti] Título:Anti-inflammatory and analgesic activities of solvent fractions of the leaves of Moringa stenopetala Bak. (Moringaceae) in mice models.
[So] Source:BMC Complement Altern Med;17(1):473, 2017 Sep 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many people still experience pain and inflammation regardless of the available drugs for treatments. In addition, the available drugs have many side effects, which necessitated a quest for new drugs from several sources in which medicinal plants are the major one. This study evaluated the analgesic and anti- inflammatory activity of the solvent fractions of Moringa stenopetala in rodent models of pain and inflammation. METHODS: Successive soxhlet and maceration were used as methods of extractions using solvents of increasing polarity; chloroform, methanol and water. Swiss albino mice models were used in radiant tail flick latency, acetic acid induced writhing and carrageenan induced paw edema to assess the analgesic and anti-inflammatory activities. The test groups received different doses (100 mg/kg, 200 mg/kg and 400 mg/kg) of the three fractions (chloroform, methanol and aqueous). The positive control groups received morphine (20 mg/kg) or aspirin (100 mg/kg or 150 mg/kg) based on the respective models. The negative control groups received the 10 ml/kg of vehicles (distilled water or 2% Tween 80). RESULTS: In all models, the chloroform fraction had protections only at a dose of 400 mg/kg. However, the methanol and aqueous fraction at all doses have shown significant central and peripheral analgesic activities with a comparable result to the standards. The aqueous and methanol fractions significantly reduced carrageenan induced inflammation in a dose dependent manner, in which the highest reduction of inflammation was observed in aqueous fraction at 400 mg/kg. CONCLUSION: This study provided evidence on the traditionally claimed uses of the plant in pain and inflammatory diseases, and Moringa stenopetala could be potential source for development of new analgesic and anti-inflammatory drugs.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Moringa/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/química
Analgésicos/uso terapêutico
Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/uso terapêutico
Comportamento Animal/efeitos dos fármacos
Clorofórmio
Modelos Animais de Doenças
Edema/tratamento farmacológico
Metanol
Camundongos
Dor/tratamento farmacológico
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 7V31YC746X (Chloroform); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171001
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1982-y


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[PMID]:28774616
[Au] Autor:Salas LA; Font-Ribera L; Bustamante M; Sumoy L; Grimalt JO; Bonnin S; Aguilar M; Mattlin H; Hummel M; Ferrer A; Kogevinas M; Villanueva CM
[Ad] Endereço:ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Electro
[Ti] Título:Gene expression changes in blood RNA after swimming in a chlorinated pool.
[So] Source:J Environ Sci (China);58:250-261, 2017 Aug.
[Is] ISSN:1001-0742
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Exposure to disinfection by-products (DBP) such as trihalomethanes (THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes in blood gene expression of adult recreational swimmers after swimming in a chlorinated pool. Volunteers swam 40min in an indoor chlorinated pool. Blood samples were drawn and four THM (chloroform, bromodichloromethane, dibromochloromethane and bromoform) were measured in exhaled breath before and after swimming. Intensity of physical activity was measured as metabolic equivalents (METs). Gene expression in whole blood mRNA was evaluated using IlluminaHumanHT-12v3 Expression-BeadChip. Linear mixed models were used to evaluate the relationship between gene expression changes and THM exposure. Thirty-seven before-after pairs were analyzed. The median increase from baseline to after swimming were: 0.7 to 2.3 for MET, and 1.4 to 7.1µg/m for exhaled total THM (sum of the four THM). Exhaled THM increased on average 0.94µg/m per 1 MET. While 1643 probes were differentially expressed post-exposure. Of them, 189 were also associated with exhaled levels of individual/total THM or MET after False Discovery Rate. The observed associations with the exhaled THM were low to moderate (Log-fold change range: -0.17 to 0.15). In conclusion, we identified short-term gene expression changes associated with swimming in a pool that were minor in magnitude and their biological meaning was unspecific. The high collinearity between exhaled THM levels and intensity of physical activity precluded mutually adjusted models with both covariates. These exploratory results should be validated in future studies.
[Mh] Termos MeSH primário: Desinfetantes/toxicidade
Exposição Ambiental/análise
Expressão Gênica/efeitos dos fármacos
Piscinas
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Adulto
Clorofórmio/sangue
Clorofórmio/toxicidade
Desinfetantes/sangue
Exposição Ambiental/estatística & dados numéricos
Feminino
Halogenação
Seres Humanos
Masculino
RNA
RNA Mensageiro/sangue
Natação
Trialometanos/sangue
Trialometanos/toxicidade
Poluentes Químicos da Água/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 0 (RNA, Messenger); 0 (Trihalomethanes); 0 (Water Pollutants, Chemical); 3T4AJR1H24 (chlorodibromomethane); 63231-63-0 (RNA); 7LN464CH2O (bromodichloromethane); 7V31YC746X (Chloroform); TUT9J99IMU (bromoform)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170811
[Lr] Data última revisão:
170811
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE


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[PMID]:28756219
[Au] Autor:Bond T; Graham N
[Ad] Endereço:Department of Civil and Environmental Engineering, University of Surrey, Guildford, GU2 7XH, UK. Electronic address: t.bond@surrey.ac.uk.
[Ti] Título:Predicting chloroform production from organic precursors.
[So] Source:Water Res;124:167-176, 2017 Nov 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Quantitative methods which link molecular descriptors for recognized precursors to formation of drinking water disinfection byproducts are scarce. This study aimed to develop a simple mathematical tool for predicting chloroform (trichloromethane) yields resulting from aqueous chlorination of model organic precursors. Experimental chloroform yields from 211 precursors were collated from 22 literature studies from 1977 onwards. Nineteen descriptors, some established and others developed during this study, were used as inputs in a multiple linear regression model. The final model, calibrated using five-way leave-many-out cross-validation, contains three descriptors. Two novel empirical descriptors, which quantify the impact of adjacent substituents on aromatic and enolizable chlorine substitution sites, were the most significant. The model has r = 0.91 and a standard error of 8.93% mol/mol. Experimental validation, using 10 previously untested precursors, showed a mean discrepancy of 5.3% mol/mol between experimental and predicted chloroform yields. The model gives insight to the influence that specific functional groups, including hydroxyl, chlorine and carboxyl, have on chloroform formation and the relative contributions made by separate substitution sites in the same molecule. It is anticipated that the detailed approach can be updated and extended as new experimental data emerges, to encompass additional precursors and groups of disinfection byproducts.
[Mh] Termos MeSH primário: Clorofórmio/química
Trialometanos/química
Purificação da Água
[Mh] Termos MeSH secundário: Cloro
Desinfecção
Água Potável
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drinking Water); 0 (Trihalomethanes); 4R7X1O2820 (Chlorine); 7V31YC746X (Chloroform)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE


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[PMID]:28716488
[Au] Autor:Azizian MF; Semprini L
[Ad] Endereço:School of Chemical, Biological and Environmental Engineering, 116 Johnson Hall, Oregon State University, Corvallis, OR 97331, United States. Electronic address: mohammad.azizian@oregonstate.edu.
[Ti] Título:Simultaneous anaerobic transformation of carbon tetrachloride to carbon dioxide and tetrachloroethene to ethene in a continuous flow column.
[So] Source:J Contam Hydrol;203:93-103, 2017 Aug.
[Is] ISSN:1873-6009
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The simultaneous anaerobic transformation of tetrachloroethene (PCE) and carbon tetrachloride (CT) was evaluated in a continuous flow column. The column was packed with quartz sand and bioaugmented with the Evanite culture (EV) that is capable of transforming PCE to ethene. Azizian and Semprini (2016) reported that PCE and CT could be simultaneously transformed in the column, with PCE (0.1mM) transformed mainly to ethene and CT (0.015mM) to chloroform (CF) (20%) and an unknown transformation product, likely carbon dioxide (CO ). The fermentation of propionate, formed from lactate fermentation, was inhibited after the transformation of CT, likely from the exposure to CF. Reported here is the second phase of that study where a second bioaugmentation of the EV culture was made to reintroduce a lactate and propionate fermenting population to the column. Effective lactate and propionate fermentation were restored with a H concentration of ~25nM maintained in the column effluent. PCE (0.1mM) was effectively transformed to ethene (~98%) and vinyl chloride (VC) (~2%). Unlabeled CT (0.015 to 0.03mM) was completely transformed with a transient build-up of CF and chloromethane (CM), which were subsequently removed below their detection limits. A series of transient tests were initiated through the addition of carbon-13 labeled CT ( CT), with concentrations gradually increased from 0.03 to 0.10mM. GC-MS analysis of the column effluent showed that C labeled CO ( CO ) was formed, ranging from 82 to 93% of the CT transformed, with the transient increases in CO associated with the increased concentration of CT. A modified COD analysis indicated a lesser amount of CT (18%) was transformed to soluble products, while CO represented 82% the CT transformed. In a final transient test, the influent lactate concentration was decreased from 1.1 to 0.67mM. The transformation of both CT and PCE changed dramatically. Only 59% of the CT was transformed, primarily to CF. CO concentrations gradually decreased to background levels, indicating CO was no longer a transformation product. PCE transformation resulted in the following percentage of products formed: cDCE (60%), VC (36%), and ethene (4%). Incomplete propionate fermentation was also observed, consistent with the build-up of CF and the decrease in H concentrations to approximately 2nM. The results clearly demonstrate that high concentrations of CT were transformed to CO , and effective PCE dehalogenation to ethene was maintained when excess lactate was fed and propionate was effectively fermented. However, when the lactate concentration was reduced, both PCE and CT transformation and propionate fermentation were negatively impacted.
[Mh] Termos MeSH primário: Dióxido de Carbono/metabolismo
Tetracloreto de Carbono/metabolismo
Etilenos/metabolismo
Tetracloroetileno/metabolismo
[Mh] Termos MeSH secundário: Anaerobiose
Biodegradação Ambiental
Reatores Biológicos/microbiologia
Dióxido de Carbono/química
Isótopos de Carbono/análise
Tetracloreto de Carbono/química
Clorofórmio/química
Clorofórmio/metabolismo
Etilenos/química
Halogenação
Tetracloroetileno/química
Cloreto de Vinil/química
Cloreto de Vinil/metabolismo
Poluentes Químicos da Água/química
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Isotopes); 0 (Ethylenes); 0 (Water Pollutants, Chemical); 142M471B3J (Carbon Dioxide); 7V31YC746X (Chloroform); 91GW059KN7 (ethylene); CL2T97X0V0 (Carbon Tetrachloride); TJ904HH8SN (Tetrachloroethylene); WD06X94M2D (Vinyl Chloride)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE


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[PMID]:28629226
[Au] Autor:Abshagen K; Rotberg T; Genz B; Vollmar B
[Ad] Endereço:1 Institute for Experimental Surgery, Rostock University Medical Center, 18057 Rostock, Germany.
[Ti] Título:No significant impact of Foxf1 siRNA treatment in acute and chronic CCl liver injury.
[So] Source:Exp Biol Med (Maywood);242(14):1389-1397, 2017 Aug.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chronic liver injury of any etiology is the main trigger of fibrogenic responses and thought to be mediated by hepatic stellate cells. Herein, activating transcription factors like forkhead box f1 are described to stimulate pro-fibrogenic genes in hepatic stellate cells. By using a liver-specific siRNA delivery system (DBTC), we evaluated whether forkhead box f1 siRNA treatment exhibit beneficial effects in murine models of acute and chronic CCl -induced liver injury. Systemic administration of DBTC-forkhead box f1 siRNA in mice was only sufficient to silence forkhead box f1 in acute CCl model, but was not able to attenuate liver injury as measured by liver enzymes and necrotic liver cell area. Therapeutic treatment of mice with DBTC-forkhead box f1 siRNA upon chronic CCl exposition failed to inhibit forkhead box f1 expression and hence lacked to diminish hepatic stellate cells activation or fibrosis development. As a conclusion, DBTC-forkhead box f1 siRNA reduced forkhead box f1 expression in a model of acute but not chronic toxic liver injury and showed no positive effects in either of these mice models. Impact statement As liver fibrosis is a worldwide health problem, antifibrotic therapeutic strategies are urgently needed. Therefore, further developments of new technologies including validation in different experimental models of liver disease are essential. Since activation of hepatic stellate cells is a key event upon liver injury, the activating transcription factor forkhead box f1 (Foxf1) represents a potential target gene. Previously, we evaluated Foxf1 silencing by a liver-specific siRNA delivery system (DBTC), exerting beneficial effects in cholestasis. The present study was designed to confirm the therapeutic potential of Foxf1 siRNA in models of acute and chronic CCl -induced liver injury. DBTC-Foxf1 siRNA was only sufficient to silence Foxf1 in acute CCl model and did not ameliorate liver injury or fibrogenesis. This underlines the significance of the experimental model used. Each model displays specific characteristics in the pathogenic nature, time course and severity of fibrosis and the optimal time point for starting a therapy.
[Mh] Termos MeSH primário: Produtos Biológicos/administração & dosagem
Terapia Biológica/métodos
Doença Hepática Induzida por Substâncias e Drogas/terapia
Clorofórmio/toxicidade
Fatores de Transcrição Forkhead/biossíntese
RNA Interferente Pequeno/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Doença Hepática Induzida por Substâncias e Drogas/patologia
Modelos Animais de Doenças
Fígado/patologia
Camundongos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Forkhead Transcription Factors); 0 (Foxf1a protein, mouse); 0 (RNA, Small Interfering); 7V31YC746X (Chloroform)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217716425


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[PMID]:28625950
[Au] Autor:Ahmad I; Sabah A; Anwar Z; Arif A; Arsalan A; Qadeer K
[Ad] Endereço:Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi, Pakistan.
[Ti] Título:Effect of solvent polarity on the extraction of components of pharmaceutical plastic containers.
[So] Source:Pak J Pharm Sci;30(1 Suppl):247-252, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:A study of the extraction of polymeric material and dyes from the pharmaceutical plastic containers using various organic solvents was conducted to evaluate the effect of polarity on the extraction process. The plastic containers used included semi-opaque, opaque, transparent and amber colored and the solvent used were acetonitrile, methanol, ethanol, acetone, dichloroethane, chloroform and water. The determination of extractable material was carried out by gravimetric and spectrometric methods. The yield of extractable materials from containers in 60 h was 0.10-1.29% (w/w) and the first-order rate constant (kobs) for the extraction of polymeric material ranged from 0.52-1.50 × 10-3 min and for the dyes 6.43- 6.74 x10-3min-1. The values of (k ) were found to be an inverse function of solvent dielectric constant and decreased linearly with the solvent acceptor number. The extractable polymeric materials exhibited absorption in the 200-400 nm region and the dyes in the 300-500nm region. The rates of extraction of polymeric material and dyes from plastic containers were dependent on the solvent dielectric constant. The solvents of low polarity were more effective in the extraction of material indicating that the extracted material were of low polarity or have non-polar character. The dyes were soluble in acetone and chloroform. No plastic material was found to be extracted from the containers in aqueous solution.
[Mh] Termos MeSH primário: Plásticos/química
Solventes/química
[Mh] Termos MeSH secundário: Clorofórmio/química
Embalagem de Medicamentos/métodos
Etanol/química
Metanol/química
Compostos Orgânicos/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Organic Chemicals); 0 (Plastics); 0 (Solvents); 059QF0KO0R (Water); 3K9958V90M (Ethanol); 7V31YC746X (Chloroform); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE


  9 / 5588 MEDLINE  
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[PMID]:28603132
[Au] Autor:Alam F; Saqib QN; Shah AJ
[Ad] Endereço:Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
[Ti] Título:Airways and vascular smooth muscles relaxant activities of Gaultheria trichophylla.
[So] Source:Pak J Pharm Sci;30(1):199-203, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The aim of this experimental work was to explore the potential pharmacological activities of Gaultheria trichophylla Royle in hyperactive respiratory and vascular conditions. Gaultheria trichophylla was extracted with solvents, phytochemical detection tests were performed, and rabbit trachea and aorta strips were used to evaluate its effects on airways and vascular smooth muscles. Qualitative phytochemical tests showed the presence of flavonoids, alkaloids, anthraquinones, saponins, terpenoids, and condensed tannins. The methanol extract caused inhibition (EC values of 3.12 mg/mL) of carbachol (1 µM) and partial relaxation of K (80 mM) caused contractions in tracheal strips. The chloroform extract was comparatively more potent against carbachol than K+ induced contraction with EC values of 0.64 and 2.26 mg/mL, respectively. However, the n-hexane extract showed more potency against K than cabachol induced contractions, as in case with verapamil, with EC values of 0.61 and 6.58 mg/mL, respectively. In isolated prepared trachea, the extracts displaced the carbachol concentration response curves and maximum response was suppressed. In rabbit aorta preparations, methanol and n-hexane extracts partially relaxed phenylephrine (1 µM) and K induced vasoconstrictions. However, the chloroform extract inhibited phenylephrine induced contractions and exhibited a vasoconstrictor effect at lower concentrations and a relaxant effect at higher concentrations against K precontractions. The data indicates that, in addition to others, the extracts of G .trichophylla possess verapamil like Ca channel blocking components which explain the possible role of this plant in respiratory and vascular conditions.
[Mh] Termos MeSH primário: Broncoconstrição/efeitos dos fármacos
Broncodilatadores/farmacologia
Bloqueadores dos Canais de Cálcio/farmacologia
Gaultheria/química
Músculo Liso Vascular/efeitos dos fármacos
Extratos Vegetais/farmacologia
Traqueia/efeitos dos fármacos
Vasodilatação/efeitos dos fármacos
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Aorta/metabolismo
Broncodilatadores/isolamento & purificação
Bloqueadores dos Canais de Cálcio/isolamento & purificação
Canais de Cálcio/efeitos dos fármacos
Canais de Cálcio/metabolismo
Clorofórmio/química
Relação Dose-Resposta a Droga
Feminino
Hexanos/química
Técnicas In Vitro
Masculino
Metanol/química
Músculo Liso Vascular/metabolismo
Compostos Fitoquímicos/isolamento & purificação
Compostos Fitoquímicos/farmacologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Coelhos
Solventes/química
Traqueia/metabolismo
Vasodilatadores/isolamento & purificação
Verapamil/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Calcium Channel Blockers); 0 (Calcium Channels); 0 (Hexanes); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Solvents); 0 (Vasodilator Agents); 2DDG612ED8 (n-hexane); 7V31YC746X (Chloroform); CJ0O37KU29 (Verapamil); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


  10 / 5588 MEDLINE  
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[PMID]:28598341
[Au] Autor:Lodhi A; Hashmi I; Nasir H; Khan R
[Ad] Endereço:Institute of Environmental Sciences and Engineering (IESE), School of Civil and Environmental Engineering (SCEE), National University of Sciences and Technology (NUST), H-12 Sector, Islamabad, Pakistan E-mail: imranhashmi@iese.nust.edu.pk.
[Ti] Título:Effect of trihalomethanes (chloroform and bromoform) on human haematological count.
[So] Source:J Water Health;15(3):367-373, 2017 Jun.
[Is] ISSN:1477-8920
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:With the increasing concerns about the harmful effects of disinfection products, the process of chlorination is becoming questionable. Bromoform and chloroform are among the most frequently occurring disinfection by-products. Haematological parameters are an important indicator of human well-being which is why the prime objective of the current study was to conduct a dose-response assessment to investigate the effects of trihalomethanes on human haematological count. Blood samples of healthy subjects were exposed to different concentrations (10, 30 and 50 µg/mL) of chloroform and bromoform in vitro to analyse how these compounds affected the haematological count with increasing dose concentrations. Headspace gas chromatography analysis was also conducted on samples to assess the difference between measured and spiked values of doses. The results indicated that the damage caused by bromoform was statistically more significant as compared to chloroform. Haemoglobin (HGB) and mean corpuscular haemoglobin concentration levels lowered as they were significantly affected (p < 0.05) by bromoform at all administered doses. It also significantly damaged platelet level at doses of 30 (p < 0.05) and 50 µg/mL (p < 0.01). Conversely, the damage caused by chloroform was statistically less significant (p > 0.05).
[Mh] Termos MeSH primário: Contagem de Células Sanguíneas
Clorofórmio/toxicidade
Desinfetantes/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Adulto
Relação Dose-Resposta a Droga
Índices de Eritrócitos/efeitos dos fármacos
Hematócrito
Seres Humanos
Trialometanos/toxicidade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disinfectants); 0 (Trihalomethanes); 0 (Water Pollutants, Chemical); 7V31YC746X (Chloroform); TUT9J99IMU (bromoform)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.2166/wh.2017.207



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